︒ ヮ

4 0 3

・・

1・1・

0 1

・

白かれ 6 ι 2 3 6

・fld

けは山け

‑ MW '

いり{ハい(いい

{ { { { { { { [ { { { I l i l

‑

‑ 1 { 24687623041314JmJJ

問J

行斗幻

‑ロ

OミJ

・ ︑ ︐ ・

nヲ

n y︐ 令︿

句 ︐

‑2

・5

・・

・

0 1 2

・0 8 L n

し

n H ふ

1576261J38J7132

う1・

10.0 (8.36， 11.8) 2.29 (1.89， 2.731 7.1.1 (ぅ.83，9.081 ).J9 (2.27， 4.59) 0.3ι(0.08， 0.67) 2.07 (1.1')， ).0う}

O.う6 (O.26， 0.91)

‑0.07 ( ， 0.25) 0.05 (‑0.05， 0.251 0.22 (‑0.01， 0.53)

‑0.10 ( ，0.20) 0.11 (‑0.05， 0.35)

1.2守(0.71，1.96) 1.25 (U.70， 1.89) 1.02 (0.53， 1.60) 0.60 (0.01" 1.291 0.26 (‑0.04， 0.701 0.1，5 (0.10， 0.901 0.0) ( ， 0..101 0.55 (0.26， 0.89)

‑0.02 ( ，0.18) 0.21 (0.07， 0.)91 0.77 (0.19， 1.1.1.)

ω ω ω

引けり

ω η ω ω H N υ

幻計八引

ω ω

川刊

H M η ω

川引

︐ ︐ 旬 ︑

J︑Jn7︑_J

q︐

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h句'n7

令 ︐ ︑ ︐ .

︐

o q︐ 内

'RJZJRuq︐

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b︐

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1 1 1 1 1 1 2 1 1 2 1 2 2 t 2 1 5 1 5 1 1 1 1

ji ll

︐︐

︐︐ 乙 % ︑ ハ

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・九九九

ahh丸

t h i 5 5 3 8 2 1 0 E 2 8 9 8 2 1 ι n J l J

︐ 叫

︐

J A

‑ E

・・・・・・・・・・・

1 i h

‑

‑ i l l

‑

‑ 1 2 t o o o

‑

‑ 1 1 0 1 1 1 1

い

IfLit‑{{{{({({(Ill‑{({{(

n7︑ ︿

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吋︿吋

r nヲ吋

‑A U' on u

弓4︑3・_'

EB '今 ︐

LE J' hu nU

39224259t3834402ιι

心心

︒︐ A J l i l

‑

・・

・

111

上 ' い・

L・h・L11011011121113202t 0.000 0.000 0.000 0.000 0.02 0.000 0.000 0.67 0.57 0.13 0.53 0.29 0.000 0.000 0.000 0.08 0.17 0.0) 0.85 0.000 0.81 0.002 0.0) 6

2 4 9 6 7 2 6 7 9 1 1 7 8

う

2 0 2 2 3 0 6 7 3 0 3 2 7 0 3 1 7 4 9 8 4 3 5 8 9 8 5 3 1 3卯 9 2 7 1 1 0 2 2 1 1 7 6 1 3

月

うち 1 2 All mnlignont. neoplasms

Leukemla

All excepl l~ukcmln

Dlgc.llve or，nns ond perlloneum r Esoph.g¥l'

Slomoch Colon RccLurtl Liver， pri~nry

Gnllblndder nnd bllc rlUCl3 ro.nCTr.'IJ:l

Olher， unspec1r1ed Rcsplrolory 'y"lem

Lung fcmnlc brCHsl I

Ccrvlx ulerl nnd utcrust Ccrvix Ulcrl・

OVl¥ry' Pros.tat.e I Urlnary lrncl

Hnll~nnnl lymphorna Huttl ple "ye 101011 OLhcr

一一ニ

NUrT¥lJC[S !n pdr(!nthcses lndic.l ζc a 90¥ c~ntidencQ int~~ ・'J'dl.

t Rlsk est1~atlon for thesa 51t~s is basca 00 clther maies or femalc5 only.

='1\ ・.由郡 ~aJl・2ぇ7III‑.t:l司花町"X11 '<'1のみのいずれh'に甚イ ( .

tt p-v~luc ba5ed on the test :O[ lncrcaslnq trcnd ln radldtlon dose 杭刷開閉山 1 M~n!n 向白仲，t0: >;t寸(.航

Itt 9.sca on ~1.719 subjccts cxposcd to 0.01

・

Gy I.vcraqc 0.295 Gyl 0.01 Gy I1上(rr.] 0.295口yIに何時lf:叫.;"19人に申づf Thc rls. cocfflc;cnt. shown In thls table dlf~cr .llghtly (rom those presented In ^ppcndlx Tablc 11 In LSS R~port 11 P.¥ rt 1 (RERF， TR 12・91) duc tc th~ dllterencc :0 roundlnq procedurc applled to lndivldual dose estlm~tc5.

4伊良"承f・1λ7~I: ft Ij 個人帽園町樫 ; t に用いf:開泊五人向1T泌が興~ ~ため. "3~' 直訊 11 刊の iill 前 (nEIIF. TII 12‑07IU，(1晶Hに吊Lたも円l~でや圃をる

IA弧内0)rt 凶 11 開~'.1.1 fQ I宅間企ij;1

.JAKKI M 91 005

3. 7 . 3 & » « * & : - k S 5 E C 'J x 9 o f l l ^ f f l ( 1 0^JA • %• • G y sj 0

(NUREG/CR-4214. Table 1. 9)

Site

Japanese Life Span Study

Study Nagasaki Tumor Registry

Ankylosing Spondylitis Patients Esophagus

Stomach Colon Rectum Pancreas

0.21 (0.24) 1.04 (0.30) 0.A6 (0.13)

2.36 (1.07) 0.51 (0.31) 0.47 (0.28) 1.04 (0.83)

0.25 (0.16) 2.11f(1.08) 1.70 (1.21)

0.70 (0.61) Other and

unspecified 0.53 (0.17) 0.70°(0.S2)

TOTAL 1.80^(0.45) 5.08c

Estimates are those given In .and (1983). All estimates are given in terms of organ dose ulth Japanese estimates based on an RBE of 11.3 for neutron exposure.

These estimates (and their standard errors) are adjusted by multiplying by mortality-Incidence ratios taken to be 0.77 for the stomach, 0.5 for the

Intestine (colon and rectum), 0.90 for pancrease, 1.0 for liver.

Since the Life Span Study estimates for rectum and pancreas would be negative, this total Is less than the sum of the estimates presented.

This csclmatc Is for liver cancer only.

This estimate is obtained by summing the individual sites. It probably overestimates the true total since estimates for sites not g_lven would be negative.

Alternative estimates of dose to the scomach yield estimates of 2.81 (1.43) and 0.75 (1.21).

- 125 表 3.7. 3

S1ce

Esophagus Stomo'lch Colon RecCum Pancreas Other and uns pec 1f led 1"01"AL

.1:¥Ef¥1 r‑.l 91..005

胃腸管癌による死亡リスクの推定値(1 0~ 人・年・ G y当り

の死亡を表わし、括弧内は標準誤差を示す ) (NUREG/CR‑4214. Table 1. 9)

Stud y Japanese Llfe Nagasakl

b Anky10slng Spo'ln Study Tumor Reglscry Spondyl1cls

Paclencs

0.21 (0.24) 0.25 (0.16) 1.04 (0.30) 2.36 (1.07) 2.11f(1.08) 0.46 (0.13) 0.51 (0.31) 1.70 (1.21)

0.47 (0.28)

1.04 (0.83) 0.70 (0.61)

0.53 (0.17) 0.70d(0.S2)

1.80c(O.45) 5.0ac

aEsClmatcs are chose glven ln and (1983). Al1 esclmaces are glvcn ln cerms oC organ dose ulch Japanese esclmaces bo'lsed on an R8E of 11.3 for neutron exposure.

bThese es E1ma Ees〈and Eheir s Eandard errors)are adjuS Eed by mulEip1yinsby mortallty‑Incldence ratlos caken to be 0.77 Cor the sto田ach. 0.5 for che lncesclne (colon and rectum). 0.90 Cor pancrcase. 1.0 for l1ver.

cSlnce the Llfe Span Studv estlmates Cor rectum and pancreas uould be negaclve. thls cocal 1s less tho'ln chc s回Uof che estlmates presented.

dTh1s estlmo'ltc Is for 11vcr cancer only.

eTh1s esclmate Is obtalned by summlng the lndlvldual sites. It probably overesclmates che truc coto'll slncc cstlmates Cor sltes not a1ven uould bc ncgatlve.

fA1ternatlvc cstlmates of dosc to thc sto田o'lch ylcld esclmates of 2.81 (1.43) and 0.75 (1.21).

125

. I A K K I M 91 OOf)

3.7.4 H t t H A S R t f d P g * («8|5) ©&ftf8?S«{;:#5 - K f t B £ S © f f l * f •; x *

(UNSCEAR '88. Table 25)

T a b l e ?S

Relative r h k of second cancer following radiotherapy tor benign gynaecoloqlc disorders and for cervical cancer

[H6, 8 1 ? )

(Cancer patients followed for at least 10 years: other patients followed for a variable length of time, but generally more than 10 years.

Risks significant it the 0.05 or better level are underlined.)

Relative risk Organ dose level

and site Radlothe rapy treatment NO

of second cancer radiotherapy

treatment Cancer

patients

Non-cancer patients

High doses a/

Colon 1.1 1.1 1.3

Rectum 1.8 1.? 1.4

Uterine corpus 1 .0 ;.B OJL

Ovary 0.9 0,5

Bladder 3.5 ?.i U.

Other genital 3.? UL

Intermediate doses £/

Stomach 1.0 0.8 0.6

Pancreas 1.? o.s ^0.9

Kidney o.a ^J.I ^?.l

Oesophagus 1.1 0.0

Sma 11 bowe1

!.* ^{1 .3} ^5.0

Gallbladder 0.8 0.9 1 .5

tow doses (remote sites) c/

Lyng ?.3 0.9 hi

Breast 0.7 0.9 0.9

Thyroid 1.4 0.6

Oral cavity 1 .7 1.9 1.7

Salivary gland 1.7 0.0

Brain 0.6 J.O

General systemic cancer of unknown original site

Leukaemia 0.9 ?.3 0.6

Multiple myeloma 1 .4 0.0

Lymphoma 1.3 ?.3 0.3

Hodgkln's disease 1.0 1.1

a/ for cancer patients around 10 Gy; for non-cancer patients 1-10 Gy.

b / for cancer patients 1-10 Gy; for non-cancer patients comparatively smaller.

c/ for cancer patients around 0.1 Gy; for non-cancer patients comparat1vely smal ler.

126

.I.¥EHI :‑‑1 ~1 ()O !i

表 3.7. 4 良性婦人病及び子宮癌 ( 頭部 ) の放射線治療に伴う二次的発生癌の相対リスク

( UNSCEAR ・88. Table 25)

T a b

， .

²⁵

R.ldtlv. rlü_j)L_~~~o-，，-d_~ó!!1U~ follolJ、nQ radlolh.ranv f or b!'nlan Qvn~ t!' coloQ1C d1~ord~r ， and tor cerv'cal canc

・

lW&. 812)

(Canc.r patl.nls follolJed for al

，

^.^.^.¹¹⁰^r^e^a^r

: ，

olh.r patl.nt

，

follolJ.d lor 0 varlabl. '.nqth of 11m.. but 9.n...lIr mor. than 10 r.ars.

Rllk. slqnlftcant iI th. 0.05 or better

' . v . l

^{ar. under}¹^¥^ned.)

Relatlv. rl.t Orqan dO'. '.v.l

and s 11. Radlothorapr Ir..tmenl

。 "

of s.cond c.nc.r rad loth.rapy tr.atm.nt Ca.ncer Non‑cancer

patlent. pat 'ent s

Hlqh dose.呈/

Colon 1.1 1.1 1.3

R.ctum L旦 ¹^.² ¹^.⁴

Uter1ne corpu'5 1.0 2.日

LL01.且i 2 1

Ovary 0.9

81.dd.r

L3よS 2.1 Oth.r 9.n 1 ta 1

Intermedlat. 40... !!I

510同Ch 1.0 0.8 0.6

P.ncr.as 1.2 0.5 0.9

K Idn.y 0.8 2.1 2.1

Oesoph.qu. 1.1 0.0

Sm3 11 bOlJ.l 2. 1.3 5.0 Gallbladd.r 0.6 0.9 1.5 lOlJ do... (romot. • tt..) s/

lyn9 L1 ^0.9 u

8 r . . .

^t ⁰^.⁷ ⁰^.⁹ ^0.9

Thyrold 1. 0.6

日ra1 cavlty 1.7 1.9 1.7 501¥vory qland 1.1 0.0

Bra ¥n 0.6 2.0

G.n.rol .y.temlc concer

。

^funkoo^lJn orI9'n.l .lIe

l.ukaeml. 0.9 L1 ^0.6

~u 1t lplo mr.10tn.l 1.4 0.0

lymphon唱 1.3 L1 ^0.3

Hodgk¥n's d1sease 1.0 1.1

al for c.nc.r patlenl. .round 10 Gr: for non・canCH patl.nt. 1‑10 Gy. br for cancor pat1.nl. 1‑10 Gr; for non̲εanc.r pa t lontも comparH1v.'y

Sm3 11.r.

f.1 for cancer pdt1ents around 0.1 Gy: for non...cancer pat1ents comparat'velY'5mal1er.

126

. J A M ! M 91 00;")

3.7.5 ^gm <sisu) <DmMUfemfcttom<Dmv) z?

t&mxt:

(UNSCEAF '88. Table 26)

R e l a t i v e r i s k and exce'.s cases of c a n c e r f o l l o w i n g i r r a d i a t i o n t o t r e a t c e r v i c a l c a n c e r

[B38J

(90X confidence Intervals In parentheses.)

Relative risk C*cess cases Second cancers at 1 Oy a/ per 10* PrCy

Colon 1.00 (0.00-1.0?) 0.01 | ;-0.03- 0.18)

Cecum 1.0? (0.99-1.09)

-Rectum 1 .0? (1.00-1.04) 0.06 { 0.00- 0.16) All female genital 1.01 (1.00-1.0?) 0.05 ( -0.01- 0.17) Ovary 1.01 (0.98-l.H) O.OS ( -0.03- 0.60) Vagina 1.03 (1.00-1.08)

-Other genital 0.98 (0.95-1.07) -0.01 ( -0.0?- 0.03) Bladder 1.07 (1.02-1.17) 0.12 ( 0.01- 0.30) Connective tissue 0.95 (0.89-1.13) -0.01 ( -0.03- 0.03) Stomach 1.69 (1.01-3.?S) 3.16 ( 0.05-10.40) Pancreas 1.00 (0.7?-1.6?) 0.00 ( -0.65- 1.43) KIdney 1.11 (1.03-3.?*) 1.10 ( 0.06- 3.50) Breast 1.03 (0.13-?.?9) 0.54 ( -14.6-?!. 7 ) Thyroid 13.30 (0.00-77.0) 6.87 ( -?.04-39.? ) Leukaemia

C U 1.00 (0.90-1.43) 0.00 ( 0.00- 0.17) Al and Cut 1.14 (1.00-1.45) 0.10 ( 0.00- 0.31)

a/ See original publication for details of the calculations.

3.7.6 W * « o r & « A # c f c . t S - » : W 5 8 4 ) S © f f l W y x * (UNSCEAR '88. Table 27)

T a b l e 27

Relative risk of second cancers In patients treated for ovarian cancer [Rll)

(Risks significant at the 0.05 or better level are underlined.)

Relative risk

Site of Non-Irradiated patients Irradiated

second cancer patients H . 6713 a/ H . 5455 b/ N . 6596 a/

All sites 1.1 1.5 2.1

Bladder 0.4 ?.B £/

Breast 1.0 1.1 2.2

Colon 1.3 7.9 2.6

Connective tissue 0.9 3.3 £/

Endometrium 2.9 4.5 5.9

Leukaemia 0.3 1.3 9.3

lung 2.0 0.7 0.8

Lymohoma 1.6 U. LI

Hyeloma 2.B 0.0 c/

Rectum 1.1 0.3 1.1

Stomach 0.8 0.5 £/

3/ Study group from United States National Cancer Institute End Results Program.

b/ Study of a survey of 70 United States medical centers using chemotherapy.

c/ Less than 2 patients observed.

127

00日

ーの叫

υ~I

，J:¥Elil

の放射線治療に伴う癌の相対リスク子宮癌(頭部)

3. 7. 5 表

と過剰死亡

Table 26) LL!!..ムょ̲ 2主

R flli司t1vl!'r1u and tr:crn CdH"もof can:ctr

，

^ollo^¥J^lⁿ^q^I^r^r^a^d^¥^o^l^l^¥^oⁿ^l^otr~_t_cfr.:-' 、 (3I (.1nCt'r [638 J

(UNSCEA . Ji 88.

(90'; con'Id.nc. Inttrv.ls In p.ronth.sol.)

:xcess (Isr"

p.r 10 PYGr

Colon Cecum Rc‑ctum

AII '....1. 9.n".1 Ovar'j

Vaqln.

Othor g.n11.1 81.dder

Connec t 1 ve t 1 s!ue Sto...ch

panc rta S

~ ldn.y Brrd ¥ t Thyrold leuk.eml.

CLL Al .nd CMl

0.01 (・0.03‑ 0.18) 0.0& ( 0.00‑ 0.1&) 0.05 (‑0.01・0.11) 0.05 (‑0.03‑0.60)

・0.01(・0.02・0.03) 0.12 ( 0.01・0.30)

‑0.01 (・0.03‑0.03) 3.16 ( 0.05・10.40) 0.00 (‑0.65‑1.43) 1.10 ( 0.06‑ 3.50) 0.54 (・14.6‑21.1 ) 6.81 (・2.0・39.2 ) R.hl1v. rllk

.t 1 Oy呈/

1.00 (0.00‑1.02) 1.02 (0.99‑1.09) 1.02 (1.00‑1.04) 1.01 (1.00‑1.02) 1.01 (0.98‑1.14) 1.03 (1.00・1.08) 0.98 (0.95・1.07) 1.01 (1.02‑1.17) 0.95 (0.89‑1.13) 1.69 (1.01・3.25) 1.00 (0.71‑1.62) 1.11 (1.03‑3.24) 1.03 (0.13・2.29) 13.30 (0.00‑11.0) Second cdn(erも

0.00 ( 0.00‑0.17) 0.10 ( 0.00‑0.31) 1.00 (0.90・1.43)

】.14(1.00‑1.45)

且I S.e .rl91n.I publ1c.tlon

，

^o^rdet.I1s 01 the calcuhtlons.

卵巣癌の治療患者における二次的発生癌の相対リスク表 3.7. 6

Tab!e 27) (UNSCEAR . 88.

T • b 1 e 27

Rel. t1 v~ rlsk 0' 1econd c.ncen ln_ J) .tle~t1 tr..teQ̲

，

or ov.rl.n cancer (Rll J

(RI

，

k' 119nl'Ic.nt .t the 0.05 or better level

. r .

underllned.) Ae1atlve rlsk

)rr.dl.t.d patlents Hon‑Irr.dl.ted p.tlents

SIt. 01 second cancer

M・6713呈I H・5455~I N・6596呈/

U日一 M一日一

u u

一い一 MM

﹁U

‑U U

u u u u u u

一川

UUMMU

日一川川口

M 一M U MMMMM一 All sltes

B 1adder Brea I t Colon

Connectlve tlslue Endometrlum Leukaeml.

lung Lymohoma

例yeloo唱

Rectum 5to同 ch

互15tudy 9rouP Irom Un1ted St.tes N.t1on.l C.ncer Inst1tuh End Results progr.m.

民IStudy 01 • survey of 70 Un1t.d States med¥ca 1 cont.rs uslng chemother.py.

~I Le" than 2 patlents observed.

127

.JAKK'l M 91 (Kin

m 3.7.7 -frmufe<D%m%&mK%?z,fem<Dmmo&\

(UNSCEAR " 8 8 , T a b l e 4 3 )

T a b 1 f 43

r f f r e t of type of treatment on c u m u l a t i v e I n c i d e n c e of s e c o n d p r i m a r y cancers In p a t i e n t s w U h g e n e t i c r e t i n o b l a s t o m a

1 0 1 5 )

Cumulat1 ve IncIdence Type of Site of Number of Number (per cer it> at

treatment second cancer patients of

second second cancer patients of

second

cancers 12 years 18 years

Radiotherapy All sites no ⁴ 4.? 4.?

In radiation field M O 3 2.9 2.9

Outside radiation field lee ¹ ^1.0 ^{1 .0}

Radiotherapy All sites 62 e 6.6 14.?

with In radiation field 62 4 4.2 9.9

chemotherapy Outside radiation field 65 5 4.6 7.5

Chemotherapy All sites 3 1 100 100

Ho r a d i o t h e r a p y .

no chemotherapy All sites 48 0 0 0

3.7.8 i ^ T f i (SI315) 0 » f t « t e 8 K : # 3 J B A ® : i & M & £ f f i

(UNSCEAR '88, Table 44)

T a b l e

Comparls on of oredlctec 1 and observed excess second < cancers 1 n women Irradiated to treat cervl ical cancer

[B12]

Second Risk Predicted Observed

primary coefficient Organ dose (Gy) excess excess cancers (cases per

10* PYGy) [C4]

cancers cancers a/

S t o m a c h 1.6B 2.0 ( 0 . 5 - 3 . 5 ) 60 •3

Colon 1.12 5.0 100 • IS

Liver 0.70 1.5 (0.S-2.5) 20 0

Pancreas 0.99 1.5 (0.3-3.0) 25 •9

lung 3.94 0.3 (0.1-0.6) 25 •77

Breast 5.82 0.3 (0.1-0.6) 37 -101

Kidney 0.8B 2.0 (0.6-3.5) 30 -6

Bladder o.ea ³⁰ ⁴⁷⁵ ^•82

thyroid 5.80 0.1 (0.0-0.3) 15 • 4

lymphoma 0.27 -10 ( 3 . 0 - 1 3 ) 50 • 15 Acute and Nl 2.70 7.5 ( 3 . 0 - 1 3 ) b / 1 0 0 0 • 13

leukaemia 2.5 (0.8-3.3) c/ 350 • 13

0.3 (0.1-0.4) d/ 45 • 13

a / In women, except those with leukaemia, l i v i n g more than 10 years:

women w i t h leukaemia, values are for 1 -20 years a f t e r i r r a d i a t i o n . b_/ Averaged over e n t i r e bone marrow.

c / Excluding pelvis c o n t r i b u t i o n .

d / Excluding p e l v i s , lumbar spine, and upper femur c o n t r i b u t i o n s .

128

﹁川リ) ( (

‑}

' t

¥1 .J:¥ 1・:HI

二次的な癌の累積発生率に対する治療の種類の影響表 3.7. 7

Table 43)

'

of ~(t cond_Q r'm.HY cancpr¥ 'n natltnt¥ ¥1~~y 1th Qenrt¥c rp1 lno~l..tom.

5 J (UNSCEAR • 88，

Cumu ，lat 1 '1ft 1 nc I dtnC f'

(por cont> ot Humbrr

01 stcond

cancers 12 y.ars Humbcr of

pat 1.nts 51 t. 01

stcond canCtr Typ. 01

troa tm.nt

18 yo..s

︐ ︐

a w' n V

‑2

‑

・・可﹃ 290

4・E

1'0 140 188 411

，

110¥

In rodlaUon 11.1d Out

，

1d. radlat!on 11.1d Radlothtrapy

14. ? 9.9 ).5 6.6

'.2 4.6 225

6 6 6 411

，

11.

，

In radl.t!on '1.ld Out i

、

d. radlatlon '1.1d Radlolh.rapy

"llh chtmotherapy

100

。

100

.8 A 11

，

1 te

，

Ho r.dloth.rapy.

no ch.molhtr.py 411

， I t . ，

Chemothtrapy

の放射線治療に伴う婦人の二次的発生癌子宮癌〈頭部)

表 3.7. 8

に関する推定と観測の比較 Table 40

Tabl. 4c

c omoar

、

50n of Dred

、

ctt"d.lnd obstrvpd excess second cancers 1n、..omen 1rradhted to treat cerv

、

cal Celncer

[8121

(UNSCEAR . 88，

Obsorvod excess cancers Predlchd

excess cancers Rlsk

co.fflcl.nt (cases per

10' PY6y) [C]

vd ea

drr n H

︒ ︐ ︑

︒

c1n era

ea nv '

Or90n do， " (6y)

.1 510n唱ch

Colon l1y.r Pancro.s lung 8r.. s t

~1dn.y

810ddor lhyrold lymphon唱

Acute .nd Nl leuk..m¥.

‑3

・

・101

・6

・

nu nu

内UF3F3噌'nu'

ョ ︐コ︽

un un uF 3

602223371SOS‑ 司t

︐.

︑内

U句dー

2.0 (0.5‑3.5) 5.0

1.5 (0.5・2.5) 1.5 (0.3・3.0) 0.3 (0.1‑0.6) 0.3 (0.1‑0.6) 2.0 (0.6・3.5) 30

0.1 (0.0‑0.3)

‑10 (3.0‑13) 7.5 (3.0‑13) 皇J 2.5 (0.8‑3.3) ^t^;^，^.1 0.3 (0.1‑0..) !!I

司ζ

︒3a

司

4令

nu an vn uv

句'nu

曹 ︑ . ﹃ ︐ a u

︒

a︒

aa nv au wa Ma u.

︑ ︐

•••••••••

11003500502

且IIn worntn. tll'ceot those wUh leuS:.aem1a. 1'''''"9 more theln 1日years: for

，"，o~en w1th leuklem1a. values art for 1‑20 years after 'rrad1at1oo.

主/，Ayeraged over制 tl.. bon.同 rrow.

y Excludlng P.1Y¥s contr¥butlon.

重/Exc1udlng pelY¥s， lumb.r sp¥ne. and upp.r f.mur contr¥bul¥ons.

12H

• l A K K I M 91 ()()!">

3.7.9 jftfSiftl 1 - 3 O ^ f f l f c f c t t S l O ^ A • Sf. • rad^<9

SB \1 q-<b$iB.W 0-9 10-19 20-34 35-49 50 +

?} tt

M M M S " 2.20 2.20 2.20 2.20 2.20 2.20

M i " 0.00 0.54 2.4S S.10 6.79 3.64

ftifi" ^0.07 ^0.07 0.13 0.21 0.56 0.26

W^{c /} 0.40 0.40 0.77 1.27 3.35 1.53

J)S'-' 0.26 0.26 0.S2 0.84 2.23 J.02

« F " 0.70 0.70 0.70 0.70 0.70 0.70

K " 0.24 0.24 0.45 0.75 1.97 0.90

W S j i S " 0.04 0.23 0.50 0.92 1.62 0.81

•J >'<«€'•* 0.27 0.27 0.27 0.27 0.27 0.27

•f«Of|b* 0.62 0.38 1.12 1.40 2.90 1.52

£ T " ) S 5 { 2 ' 4.80 S.29 9.11 13.66 22.59 12.85

W ; S S " 5.80 5.80 5.80 5.80 5.80 S.80

?U*' 0.00 7.30 6.60 6.60 6.60 5.82

a*' ^0.00 ^0.54 ^2.45 ^5.10 ^6.79 ^3.94

fiifi" ^0.07 0.07 0.13 0.21 0.S6 0.28

{?'•' 0.40 0.40 0.77 1.27 3.35 1.68

se*^v ^0.26 ^0.26 ^0.52 ^0.84 ^2.23 ^1.12

W'-' 0.70 0.70 0.70 0.70 0.70 0.70

W' 0.24 0.24 0.45 0.75 1.97 0.99

,m&" ^0.04 ^0.23 ^0.50 ^0.92 ^1.62 ^0.88

<l >/<5£" 0.27 0.27 0.27 0.27 0.27 0.27

•fraffc* 0.62 0.38 1.12 1.40 2.90 1.64

±x <»•&&' 8.40 16.19 19.31 23.86 32.79 23.10 a. 1969-1971 (f<r5S-*[iaiStKAn(t4S'J)m^.'ft5>ffii:L/';'l'-7T(Sf*L/:?1fS«f.«

b. 8 i « S B t f f * i : «!SS A/ittttf 'I * 7 «9Sft*t0.38T-«JE £ il/ilO'A • ^-/r.dMi')

na«4ffiw«mt:.

d. ffiSl£li(«f-*-3S)X0.2t:«-?i,<Ti»o. SBSB$¥-ft20-34^i;-t-tLTIil5.T.<O>H ttWt35^STIi')^7 O i LA:. * OiS»V * 71110?* 5. AiAR. (S«ST-'ft65

^U±Wi8fi-i:«'J A ? i 7 . 0 t I t .

f. ffi*S«^fl«<7)t^TORWff)ffi<otS!JKffiafifii:tii-!;?L^:<t*^!ltWt5i(S7EL/;.

t o i l / : .

A. teOSCiitOffi WliHSSfl. «!<!. • 6 « « t l l 3 UK SUSS. <lt LET » « « ? « « J ( i 4 i ^ i i l i T i > 4 « . . fgj.J'J * » 0) J: i >«C^U A-'iit »1 i i T i • 4 i ' . W&:<ni&t LT10^,A(/a»Kl»*ff*nff.ft£lJ:n»fl))-^/ridii')JatW? l.OSfSSl A:.

«Hi J: i fECtilf-tmil'tU-itmt o i l / : .

('. f-f^TWffllffiJIlM+ifi-iHl. T^XnimSA'1 r«d fr#li 5 4U1S«(065W (Cl diSitttOSSttHUHiMKKn—3W#i 7 4 R « T - * 4 .

; . -f^T<7X^-ftTi»«»Ifrloq-:i:i 5 i . KBMf.-5?10-I9;n:jff SKtiao^ifciao*

t S t - C t {,$<£(. T'J>£< L T A 4 .

129

，1:¥1‑:1¥ I 1¥1リI ()Ofi

表 3.7. 9 ^{被曝後} ^{1 1 ‑}3 0年聞における10・J人・年・ rad当り

の部位別、性別及び被曝時年齢別の過剰癌出現頻度

llG ~Îl.

l，Ij t主 1I1状腺刷iu

~ ili '‑'

宵^U

』層処^f

U & I

E革^U 泌尿倍^u I} ;.，‑ I

，

_n重，.. そのfl.!!"

全てのtiS位' 女性

qqf;~-Il'"

礼服'

1市食道^u l'l^'l

月層<./

U，.I

RV'"

E^京冨面

リンパ腫その他ぬ全ての郡{立e

( 白血病と骨の悪性腫虜を除く )

持llV昨年令(年)

0・9 10・1<) 20・34 35・49

2.20 2.20 2.20 2.20 O.

∞

⁰^.⁵⁴ ²^.⁴⁵ ⁵^.¹⁰

0.07 0.07 0.13 0.21 0.40 0.40 0.77 1.21 0.26 0.26 0.52 0.84 0.70 0.70 0.70 0.70 0.24 0.24 0.45 0.75 0.04 0.23 0.50 0.<)2 u.27 0.27 0.27 0.27 0.62 0.38 1.12 1.40 4.80 5.29 9.11 13.66 5.80 5.80 5.80 5.80 0.00 7.30 6.60 6.60 0.00 0.54 2.45 5.10 0.07 0.07 0.13 0.2l 0.40 0.40 0.77 1.27 0.26 0.26 0.52 0.84 0.70 0.70 0.70 0.70 0.24 0.24 0.45 0.75 0.04 0.23 0.50 0.92 0.27 ^目^。27 0.27 0.21 0.62 0.38 1.12 1.40 8.40 16.19 19.31 23.86

年令荷量主平均・

50+

2.20 2.20 6.79 3.64 0.56 0.26 3.35 1.53 2.23 1.02 0.70 0.70 1.<)7 090 1.62 0.81 0.27 0.27 2.90 1.52 22.59 12.85 5.80 5.80 6.60 5.82 6.79 3.94 0.56 0.28 3.35 1.68 2.23 1.12 0.70 0.70 J. 97 0...99 1.62 0.88 0.27 0.2; 2.90 1.64 32.79 23.10 a. 1969‑1971年の合京国生命表人口{性別)の年令分布にしたがっで荷鼠LI.ニ年令別係:t

の平均.

b.原il.主主曜生存者にu^{摂されと側}t.fリ;，t:7の男女比0.38で補正された10・人・年lrad当りの過剰4包1刊の稚定.

C. 'J; ，t:₇I~ 位曜日幸年令 I:{(<干干し奇いと仮定した.

d. 総定値 I~r 年令 -35JX0.2に~づいている.経SlIu寺年令 20-34才に1tLては 15:手の~l 伏期と35^{才まではリ;:t，}?OとLた.その後のリ^71110である.たどL.被E草年令65 才以上の湖合にはリλ ?を7.0とLt".

e.^・J;t，:71:住によらないと仮定L

t " .

f. lH.傷者l~車生存者のすべての胃腸の笥の線形惟定値に年令変化が比例すると仮定L た.

g.原忽管理生存者の泌尿お径の滑4かに1..1ヒ^(sm，∞hedJ・);，t:7!1f:定低t二時三官変化が比例すると1..1と.

h. (1也の邸位の抱一一将に咽矧.町長~Ii. 0長;iH曜と幅一一11低低掠.供LET放射線で銃犯

~れると考え ';11τ いるが.絶叫リスクのよい制'f"il!泊が川られてい骨い. {正.恒:<f>伐として10^・人{館ta絞t誕生符告のIf:令とfl:の分布}・年lrod当り過量JII，l;1.0 l!'fl1定Lた.

lf.・令別f^{，f:訟は.男}f宝と女岱を合せたl空爆侵略生存者の白血病をIt<^{寸べての悪性}rJi生物による~EL:の年令別f^，f，Wニ比例するとL

'".

r

^{すべての却位}JIニJ.Iする合計U.すべての4副主が1radを受付る全身貨曜のa^，^・^'¹: (臼血病と骨の悪役雌仰を除<Iの一つの考えうる尺1ft.である.

j. TべT^{の年令で治}IXIl1Iを10苛.にとると.事電磁!f:令10‑19才にJ.Iする低IJ30才未満の省も含むことも考慮して少な〈してゐる.

12n

JAKRI M 91 -005

RELATIVE RISK AT 1 Gy (SHIELDED KERMA) AND 90% CONFIDENCE INTERVAL, 1950-85

1 Gy (gffikcrma) i: tH1 J t B U ' l X 7 & y^r90%<3ffilKr»l. I950-S5ip

LEUKEMIA

A L L EXCEPT LEUKEMIA ESOPHAGUS

STOMACH COLON RECTUM LIVER, PRIMARY CALLBLADOER PANCREAS LUNG BREAST UTERUS OVARY PROSTATE URINARY TRACT MALIGNANT LYMPHOMA MULTIPLE MYELOMA

.5 1 2 RELATIVE RISK

3 4 5 10

0 3. 7. 1 1959- 1985^0 f - ? K l o ' U f c 1 G y ( i l i $ # - v ) % V)

omM y ? Rcx9 o %ia$m?s*

(RERF TR 5 - 8 8 , F i g . 1 A )

RELATIVE RISK AT 1 Gy (SHIELDED KERMA) AND 90% CONFIDENCE INTERVAL FOR CERTAIN SPECIAL CANCERS. 1950-S5

W&n&llit-tv. 1 Gy (ffiffickei-nu) I - *." I + ZWtl'l * 7 Ti. C/

90%fiffiEM. 1950 - S S ?

L I V E R . I N C L U O I N G N O T SPECIFIED AS P R I M A R Y

K I D N E Y B L A D D E R

T U M O R S OF THE C E N T R A L N E R V O U S SYSTEM EXCEPT B R A I N

B R A I N T U M O R S T O N G U E P H A R Y N X NOSE L A R Y N X

S K I N CANCER EXCEPT M E L A N O M A BONE

•

.5 1 2 R E L A T I V E RISK

El 3.7.2 1 9 5 O - 1 9 8 5 ^ 0 r - ^ ( c S o * ^ f c # S 0 a ^ ^ - t 5 1 G y (itis** - v ) S<9 © f i f t y X 7 & t f 9 0 %{I$SKPo^ll

(RERF TR 5-88, Fig.IB)

no

.J.¥EHI 九J Ht ()()fJ

RELAT1VE R1SK AT 1 Gy (SIIIELDED KERMA) AND 90% CONFIDENCE INTERVAL. 1950.85

1 Gy (辺両Hcrm.)におけるfHJ./リス7及び90%低制区間.1%0‑85年

LEUKEMIA

‑ 回 ‑

ALL EXCEPT LEUKEMIA eSOPHAGUS

STOMACH COLON RECTUM LIVER. PRIMA同Y GALLBLADDER PANCREAS LUNG BREAST UTERUS OVARY PROSTATE URINARY TnACT MALIGNANT L YMPHOMA MULTIPLE MYELOMA

‑

・

・・田・司.開園‑

七二

ーー・4・ーーー同一

‑I ll

‑

﹁1141

.1 ^.

•

⁵ ² ^3 4 5 ¹⁰

RELATlVE RISK

図 3.7. 1 1959‑1985年のデータに基づいた 1G Y (遮蔽カーマ)当りの相対リスク及び9 0 %信頼区間

(RERF TR 5‑88. Fig.lA)

RELATIVE RISK AT 1 Gy (SHIELDED KERI品 )AND 90% CONFlDENCE IN1官民VALFOR CERTA1N SPEC1AL CANCERS. 1950.85

特定の悠lニ付する. 1 Gy (jさIiike

，

'mo ) における相l.t'J 7. '7疋ぴ 90%18*同区間.1950・85竿

LlVER， INCLUOING NOT SPECIFIEO AS PRIMARY

KIDNEY BLADDER

TUMORSOFTHECENTRALNERVOUS SYSTEM EXCEPT BRAIN

BRAIN TUMORS TONGUE PHARYNX NOSE

‑‑ドーーーー

• 寸

ドキュメント内 .i U.kl-M ~ f. i ;:. II M,> f i]w sti"i'.- V-im.: j:\-ii: で li'itrijsi; L 白ゐ bll 't 封 ~ 1,-, 1!: * \ F ' l!!!,'rj.":t. II W. l' 'j*h ^'"!H!'l;i.'.fli (ページ 139-145)