〈一般演題抄録〉5.脳FDG-PETと3D-SSPによるデータベース不要アルツハイマー病自動診断ソフトの開発

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(1)一. 般. 演. 題. 抄. 録.

(2) 近畿大医誌（MedJKi 6 巻１号 nkiUni v）第3. 2 1Ａ 20 11. 2 1Ａ. ５.脳 FDG-PETと 3D-SSPによるデータベース不要アルツハイマー病自動診断ソフトの開発石井一成近畿大学医学部放射線医学教室（放射線診断学部門). Pur pos e:Topr oduceandeval uat eanaut omat i c. dat abas e ofheal t hy br ai ni mage s . Di agnos t i c. di agnos i ss ys t e m us i ngdat abas e i ndependentes t i -. pe r f or mance was compar ed be t we e nt he t wo. mat i on s ys t e m f or t he di agnos i s of mi l d Al z he i mersdi s e as e(AD) .. me t hods .. Met hods:We r et r os pe ct i ve l ys e l ec t ed 6 6s ub-. di agnos t i cac c ur ac yt ot heCAAD met hod. The. j ec t s ,i nc l udi ng3 3pat i e nt swi t he ar l yAD,and3 3 agemat c he dheal t hyvol unt e e r s(NC).I ndi vi dual. CADDI ESde mons t r at e das e ns i t i vi t yof88 % and. br ai nmet abol i ci mageswe r eobt ai nedus i ngf l uor -. CAAD s ys t em de mons t r at e das ens i t i vi t yof7 0 %,. odeoxygl uc os eandpos i t r onemi s s i ont omogr aphy ( FDGPET). The s e we r et r ans f or med us i ng. 9 64 unde rt he ROC c ur ve ofCADDI ES was0. .. t hr e e di me ns i onals t e r e ot act i cs ur f ac epr oj e c t i ons ( 3 DSSP).Wet he npr oduce dac omput e r as s i s t ed di agnos i swi t hadat abas ei ndepe ndente s t i mat i on s ys t em ( CADDI ES) ,whi c hcompar e st hepar i et al. Res ul t s:TheCADDI ESme t hode xhi bi t eds i mi l ar. s pe ci f i c i t yof7 9 % andac c ur ac yof8 5%,whi l et he s pe ci f i c i t yof94 % andac c ur ac yof8 2 %.Thear e a The ar e as under ROC c ur ves of t he CAAD me t hod i nt he par i e t aland pos t er i or c i ngul at e 8 43and0 . 93 9 gyr iwe r e0. ,r e s pec t i ve l y. Conc l us i on:TheCADDI ES met hod demons t r at -. ands e ns or i mot ormet abol i cc ount sus i ngt t e s t s .. ed a s i mi l ardi agnos t i c ac cur acy t ot he CAAD. I fpar i e t alme t abol i s m was s i gni f i c ant l yl ower. s ys t e m.Ourr e s ul t si ndi c at et hatt hi sme t hodc an. t han t he s ens or i mot or me t abol i s m,t he s ubj e c t. beappl i e dt ot hedet e ct i onofear l yADpat i e nt si n. wasaut omat i c al l ydi agnos edasAD. TheFDG-. r out i nec l i ni c ale xami nat i ons ,wi t ht hebe nef i tof. PET i mage swe r eal s oanal yz e dus i ngapr evi ous ( ) aut omat i c di agnos i ss ys t e m CAAD t hat i s. not r e qui r i ng t he ge ne r at i on of a nor mal. de pe nde nt on t he cons t r uc t i on of a nor mal. dat abas e..

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