NEA trialLEA trial
Ⅹ. 結論
本研究の結果から、持久性スポーツ競技者におけるトレーニング量の増加は安静時の⾎
中ヘプシジン濃度を上昇させることが明らかになった。また、⼀過性の持久性トレーニング は運動後にヘプシジンの分泌を増⼤させること、短期間の持久性トレーニング時における 鉄サプリメントの摂取およびLEA状態は、安静時の⾎中ヘプシジン濃度を上昇させること が認められた。
上述の結果は、スポーツ競技者における持久性トレーニングがヘプシジンの分泌増⼤を 介して鉄代謝を抑制すること、トレーニング実施時の栄養摂取状態はヘプシジンの分泌応 答に影響することを⽰すものである。また、鉄摂取量の増加やエネルギー摂取量が不⾜した 状態での持久性トレーニングが、運動誘発性の鉄⽋乏の⼀因である可能性を⽰すものであ る。
90 参考⽂献
1. Aguilar-Martinez P, Schved JF, Brissot P. The evaluation of hyperferritinemia: an updated strategy based on advances in detecting genetic abnormalities. Am J Gastroenterol 2005, 100, 5, 1185-1194.
2. Andrews NC. Disorders of iron metabolism. N Engl J Med 1999, 341, 1986-1995.
3. Andrews NC. Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest 2004, 113, 1251-1253.
4. Angeli A, Lainé F, Lavenu A, Ropert M, Lacut K, Gissot V. Joint model of iron and hepcidin during the menstrual cycle in healthy women. AAPS J 2016, 18, 490-504.
5. Anuradha CV, Balakrishnan SD. Increased lipoprotein susceptibility to oxidation following long distance running in trained subjects. Clinica chimica acta 1998, 271, 1, 97-103.
6. Asobayire FS, Adou P, Davidsson L, Cook JD, Hurrell RF. Prevalence of iron deficiency with and without concurrent anemia in population groups with high prevalences of malaria and other infections: a study in Côte d’Ivoire. Am J Clin Nutr 2001, 74, 776-782.
7. Badenhorst CE, Dawson B, Cox GR, Laarakkers CM, Swinkels DW, Peeling P. Acute dietary carbohydrate manipulation and the subsequent inflammatory and hepcidin responses to exercise.
Eur J Appl Physiol 2015a, 115, 2521-2530.
8. Badenhorst CE, Dawson B, Cox GR, Laarakkers CM, Swinkels DW, Peeling P. Timing of post-exercise carbohydrate ingestion: influence on IL-6 and hepcidin responses. Eur J Appl Physiol 2015b, 115, 2215-2222.
9. Badenhorst CE, Dawson B, Cox GR, Sim M, Laarakkers CM, Swinkels DW. Seven days of high carbohydrate ingestion does not attenuate post-exercise IL-6 and hepcidin levels. Eur J Appl Physiol 2016, 116, 1715-1724.
10. Badenhorst CE, Dawson B, Goodman C, Sim M, Cox GR, Gore CJ. Influence of post-exercise hypoxic exposure on hepcidin response in athletes. Eur J Appl Physiol 2014, 114, 951-959.
11. Banzet S, Sanchez H, Chapot R, Bigard X, Vaulont S, Koulmann N. Interleukin-6 contributes to hepcidin mRNA increase in response to exercise. Cytokine 2012, 58, 158-161.
12. Beard J, Tobin B. Iron status and exercise. Am J Clin Nutr 2000, 72, 594-597.
13. Borrione P, Spaccamiglio A, Rizzo M, Termine A, Chierto E, Campostrini N. Urinary hepcidin identifies a serum ferritin cut-off for iron supplementation in young athletes: a pilot study. J Biol Regul Homeost Agents 2011, 25, 427-434.
14. Brownlie T, Utermohlen V, Hinton PS, Giordano C, Haas JD. Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women. Am J Clin Nutr 2002, 75, 734-742.
91
15. Brune M, Magnusson B, Persson, H, Hallberg L. Iron losses in sweat. Am J Clin Nutr 1986, 43, 438-443.
16. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996, 334, 5, 292-295.
17. Craig WJ. Iron status of vegetarians. Am J Clin Nutr 1994, 59, 1233-1237.
18. Dahlfors G, Stål P, Hansson EC, Bàràny P, Sisowath C, Onelöv L. Validation of a competitive ELISA assay for the quantification of human serum hepcidin. Scand J Clin Lab Invest 2015, 75, 652-658.
19. Davies KJ, Maguire JJ, Brooks GA, Dallman PR, Packer L. Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion. Am J Physiol 1982, 242, E418-427.
20. Deli CK, Fatouros IG, Paschalis V, Tsiokanos A, Georgakouli K, Zalavras A. Iron supplementation effects on redox status following aseptic skeletal muscle trauma in adults and children. Oxid Med Cell Longev 2017, 4120421.112.
21. DellaValle DM, Haas JD. Impact of iron depletion without anemia on performance in trained endurance athletes at the beginning of a training season: A study of female collegiate rowers. Int J Sport Nutr Exerc Metab 2011, 21, 501-506.
22. DeMaeyer E, Adiels-Tegman M. The prevalence of anaemia in the world. World Health Stat Q 1985, 38, 302-316.
23. Demura S, Sato S, Kitabayashi T. Percentage of total body fat as estimated by three automatic bioelectrical impedance analyzers. J Physiol Anthropol Appl Human Sci 2004, 23, 93-99.
24. Deugnier Y, Loréal O, Carré F, Duvallet A, Zoulim F, Vinel JP. Increased body iron stores in elite road cyclists. Med Sci Sports Exerc 2002, 34, 876-880.
25. Díaz V, Peinado AB, Barba-Moreno L, Altamura S, Butragueño J, González-Gross M. Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E. Physiol Rep 2015, 3, e12475.
26. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 2000, 403, 776-781.
27. Dzedzej A, Ignatiuk W, Jaworska J, Grzywacz T, Lipińska P, Antosiewicz J. The effect of the competitive season in professional basketball on inflammation and iron metabolism. Biol Sport 2016, 33, 223-229.
28. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.
Blood 2003, 102, 783-788.
92
29. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 2006, 290, 2, 199-203.
30. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta 2012, 1823, 1434-1443.
31. Goto K, Kasai N, Kojima C, Ishibashi A. Post-exercise serum hepcidin response to repeated sprint exercise under normoxic and hypoxic conditions. Appl Physiol Nutr Metab 2017 (in press).
32. Goto K, Sumi D, Kojima C, Ishibashi A. Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. PLoS One 2017, 12, e0183629.
33. Govus AD, Abbiss CR, Garvican-Lewis LA, Swinkels DW, Laarakkers CM, Gore CJ. Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes. Eur J Appl Physiol 2014, 114, 2183-2191.
34. Gropper SS, Blessing D, Dunham K, Barksdale JM. Iron status of female collegiate athletes involved in different sports. Biol Trace Elem Res 2006, 109,1-14.
35. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997, 388, 428-482.
36. Guo W, Bachman E, Li M, Roy CN, Blusztajn J, Wong S. Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells.
Aging Cell 2013, 12, 280-291.
37. Hawley JA, Burke LM. Carbohydrate availability and training adaptation. Exerc Sport Sci Rev 2010, 38, 152-160.
38. Heikura IA, Stellingwerff T, Mero AA, Uusitalo ALT, Burke LM. A mismatch between athlete practice and current sports nutrition guidelines among elite female and male middle- and long-distance athletes. Int J Sport Nutr Exerc Metab 2017, 27, 351-360.
39. Heisterberg MF, Fahrenkrug J, Krustrup P, Storskov A, Kjær M, Andersen JL. Extensive monitoring through multiple blood samples in professional soccer players. J Strength Cond Res 2013, 27, 1260-1271.
40. Hennigar SR, McClung JP, Pasiakos SM. Nutritional interventions and the IL-6 response to exercise. FASEB J 2017, 31, 9, 3719-3728.
41. Hentze MW, Muckenthaler MU, Galy B, Camaschella C. Two to tango: regulation of Mammalian iron metabolism. Cell 2010, 142, 24-38.
42. Hershko C, Graham G, Bates GW. Rachmilewitz EA. No-specific serum iron in Thalassaemia:
an abnormal serum iron fraction of potential toxicity. Br J Haematol 1978, 40, 255-263.
43. Jenkins AB, Markovic TP, Fleury A, Campbell LV. Carbohydrate intake and short-term Jürimäe J, Jürimäe T. Plasma leptin responses to prolonged sculling in female rowers. J Sports Med Phys Fitness 2004, 44, 104-109.
93
44. Karl JP, Lieberman HR, Cable SJ, Williams KW, Young AJ, McClung JP. Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation. Am J Clin Nutr 2010, 92, 93-100.
45. Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK. Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content.
FASEB J 2001, 15, 2748-2750.
46. Kemna E. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005, 106, 1864-1866.
47. King N, Fridlund KE, Askew EW. Nutrition issues of military women. J Am Coll Nutr 1993, 12, 344-448.
48. Koehler K, Hoerner NR, Gibbs JC, Zinner C, Braun H, De Souza MJ. Low energy availability in exercising men is associated 98 with reduced leptin and insulin but not with changes in other metabolic hormones. J Sports Sci 2016, 34, 1921-1929.
49. Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, Caro JF.
Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Am Diabetes 1996, 45, 11, 1511-1515.
50. Kong WN, Niu QM, Ge L, Zhang N, Yan SF, Chen WB. Sex differences in iron status and hepcidin expression in rats. Biol Trace Elem Res 2014, 160, 258-267.
51. Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005, interleukin-102, interleukin-1906-interleukin-19interleukin-10.
52. Lefebvre T, Dessendier N, Houamel D, Ialy-Radio N, Kannengiesser C, Manceau H. LC-MS/MS method for hepcidin-25 measurement in human and mouse serum: clinical and research implications in iron disorders. Clin Chem Lab Med 2015, 53, 1557-1567.
53. Liu Q, Davidoff O, Niss K, Haase VH. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest 2012, 122, 4635-4644.
54. Loucks AB. Energy balance and body composition in sports and exercise. J Sports Sci 2004, 22, 1-14.
55. Ludwig H, Evstatiev R, Kornek G, Aapro M, Bauernhofer T, Buxhofer-Ausch V, Fridrik M, Geissler D, GeisslerHeinz K, Gisslinge H, Koller E, Kopetzky G, Lang A, Rumpold H, Steurer M, Kamali H, Link H. Iron metabolism and iron supplementation in cancer patients. Wien Klin Wochenschr 2015, 127, 907-919.
56. Ma X, Patterson KJ, Gieschen KM, Bodary PF. Are serum hepcidin levels chronically elevated in collegiate female distance runners? Int J Sport Nutr Exerc Metab 2013, 23, 513-521.
94
57. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Kern PA. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects.
Nat Med 1995, 1, 11, 1155-1161.
58. Magnusson B, Hallberg L, Rossander L. Iron metabolism and "sports anemia". II. A hematological comparison of elite runners and control subjects. Acta Med Scand 1984, 216, 157-164.
59. Mastrogiannaki M, Matak P, Mathieu JRR, Delga S, Mayeux P, Vaulont S. Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis. Haematologica 2012, 97, 827-834.
60. McClung J, Lutz L, Hennigar S, Karl J, Cable S. Associations between serum leptin, iron status, and dietary iron intake in young adults. FASEB J 2016, 30, 1, 1173-1176.
61. McClung JP, Martini S, Murphy NE, Montain SJ, Margolis LM, Thrane I. Effects of a 7-day military training exercise on inflammatory biomarkers, serum hepcidin, and iron status. Nutr J 2013, 12, 141.
62. McCormack HM, Horne DJ, Sheather S. Clinical applications of visual analogue scales: a critical review. Psychol Med 1988, 18, 1007-1019.
63. McLean E, Cogswell M, Egli I, Wojdyla D, De Benoist B. Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993-2005. Public Health Nutr 2009, 12, 444-454.
64. Miller B, Pate R, Burgess W. Foot impact force and intravascular hemolysis during distance running. Int J Sports Med 1988, 9, 56-60.
65. Moretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, Zimmermann MB. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood 2015, 126, 1981-1989.
66. Mountjoy M, Sundgot-Borgen J, Burke L, Carter S, Constantini N, Lebrun C. Authors’ 2015 additions to the IOC consensus statement: Relative Energy Deficiency in Sport (RED-S). Br J Sports Med 2015, 49, 417-420.
67. Nemeth E. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003, 101, 2461-2463.
68. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.
J Clin Invest 2004a, 113, 1271-1276.
69. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J.
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.
Science 2004b, 306, 2090-2093.
95
70. Newlin MK, Williams S, McNamara T, Tjalsma H, Swinkels DW, Haymes EM. The effects of acute exercise bouts on hepcidin in women. Int J Sport Nutr Exerc Metab 2012, 22, 79-88.
71. Nickerson HJ, Holubets M, Tripp AD, Pierce WE. Decreased iron stores in high school female runners. Am J Dis Child 1985, 139, 1115-1119.
72. Nieken J, Mulder N, Buter J, Vellenga E, Limburg P, Piers D. Recombinant human interleukin-6 induces a rapid and reversible anemia in cancer patients. Blood 1995, 86, 3, 900-905.
73. Nieman DC, Luo B, Dréau D, Henson DA, Shanely RA, Dew D. Immune and inflammation responses to a 3-day period of intensified running versus cycling. Brain Behav Immun 2014, 39, 180-185.
74. Nieman DC, Nehlsen-Cannarella SL, Fagoaga OR, Henson DA, Utter A, Davis JM. Influence of mode and carbohydrate on the cytokine response to heavy exertion. Med Sci Sports Exerc 1998, 30, 671-678.
75. Nuviala RJ, Lapieza MG. Disparity between diet and serum ferritin in elite sportswomen. Nutr Res 1997, 17, 451-461.
76. Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, Goldberg YP, Sakellaropoulos N, Ganz T, Nemeth E. Hepcidin in iron overload disorders. Blood 2005, 105, 4103-4105.
77. Park CH, Valore EV, Waring AJ, Valore EV, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001, 276, 7806-7810.
78. Parks RB, Hetzel SJ, Brooks MA. Iron deficiency and anemia among collegiate athletes: A retrospective chart review. Med Sci Sports Exerc 2017, 49, 1711-1715.
79. Pasiakos SM, Margolis LM, Murphy NE, McClung HL, Martini S, Gundersen Y. Effects of exercise mode, energy, and macronutrient interventions on inflammation during military training.
Physiol Rep 2016, 4, e12820.
80. Pedersen BK. The diseasome of physical inactivity and the role of myokines in muscle fat cross talk. J Physiol 2009, 58723, 5559-5568.
81. Pedersen BK, Steensberg A, Schjerling P. Exercise and interleukin-6. Curr Opin Hematol 2001, 8, 137-141.
82. Peeling P. Exercise as a mediator of hepcidin activity in athletes. Eur J Appl Physiol 2010, 110, 877-883.
83. Peeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW. Effects of exercise on hepcidin response and iron metabolism during recovery. Int J Sport Nutr Exerc Metab 2009a, 19, 583-597.
84. Peeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW. Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity. Eur J Appl Physiol 2009b, 106, 51-59.
96
85. Peeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW, Trinder D. Training surface and intensity: inflammation, hemolysis, and hepcidin expression. Med Sci Sports Exerc 2009c, 41, 1138-1145.
86. Peeling P, McKay AKA, Pyne DB, Guelfi KJ, McCormick RH, Laarakkers CM. Factors influencing the post-exercise hepcidin-25 response in elite athletes. Eur J Appl Physiol 2017, 117, 6, 1233-1239.
87. Peeling P, Sim M, Badenhorst CE, Dawson B, Govus AD, Abbiss CR. Iron status and the acute post-exercise hepcidin response in athletes. PLoS One 2014, 9, e93002.
88. Petkus DL, Murray-Kolb LE, De Souza MJ. The unexplored crossroads of the female athlete triad and iron deficiency: A narrative review. Sport Med 2017, 1-17.
89. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loréal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001, 276, 7811-7819.
90. Reinke S, Taylor WR, Duda GN, von Haehling S, Reinke P, Volk HD. Absolute and functional iron deficiency in professional athletes during training and recovery. Int J Cardiol 2012, 156, 186-191.
91. Rietjens GJWM, Kuipers H, Hartgens F, Keizer HA. Red blood cell profile of elite olympic distance triathletes. A three-year follow-up. Int J Sports Med 2002, 23, 391-396.
92. Rodenberg RE, Gustafson S. Iron as an ergogenic aid: Ironclad evidence? Curr Sports Med Rep 2007, 6, 258-264.
93. Roecker L, Meier-Buttermilch R, Brechtel L. Iron-regulatory protein hepcidin is increased in female athletes after a marathon. Eur J Appl Physiol 2005, 95, 5-6, 569-571.
94. Ronsen O, Lea T, Bahr R, Pedersen, BK. Enhanced plasma IL-6 and IL-1ra responses to repeated vs. single bouts of prolonged cycling in elite athletes. J Appl Physiol 2002, 92, 2547-2553.
95. Rosenbaum M, Leibel RL. 20 years of leptin: role of leptin in energy homeostasis in humans. J Endocrinol 2014, 223, 83-96.
96. Samuelson G, Bratteby L, Berggren K. Dietary iron intake and iron status in adolescents. Acta Paediatr 1996, 85, 9,1033-1038.
97. Sandström G, Rödjer S, Jacobsson S, Nelson D, Börjesson M. Increased level of serum hepcidin in female adolescent athletes. Clin J Sport Med 2017 (in press).
98. Schaap CC, Hendriks JC, Kortman GA, Klaver SM, Kroot JJ, Laarakkers CM, Swinkels DW.
Diurnal rhythm rather than dietary iron mediates daily hepcidin variations. Clin Chem 2013, 59, 527–535.
99. Shaskey DJ, Green GA. Sports Haematology. Sport Med 2000, 29, 27-38.
97
100. Sim M, Dawson B, Landers GJ, Swinkels DW, Tjalsma H, Wiegerinck ET, Peeling P. A seven day running training period increases basal urinary hepcidin levels as compared to cycling. J Int Soc Sports Nutr 2014 11, 1, 14.
101. Sim M, Dawson B, Landers G, Swinkels DW, Tjalsma H, Trinder D. Effect of exercise modality and intensity on postexercise interleukin-6 and hepcidin levels. Int J Sport Nutr Exerc Metab 2013, 23, 178-186.
102. Sim M, Dawson B, Landers G, Wiegerinck ET, Swinkels DW, Townsend M-A. The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels. Eur J Appl Physiol 2012, 112, 1889-1898.
103. Skarpańska-Stejnborn A, Basta P, Sadowska J, Pilaczyńska-Szcześniak L. Effect of supplementation with chokeberry juice on the inflammatory status and markers of iron metabolism in rowers. J Int Soc Sports Nutr 2014, 11, 48.
104. Skarpańska-Stejnborn A, Basta P, Trzeciak J, Michalska A, Kafkas ME, Woitas-Ślubowska D.
Effects of cranberry (Vaccinum macrocarpon) supplementation on iron status and inflammatory markers in rowers. J Int Soc Sports Nutr 2017, 14, 7.
105. Smith JA, Kolbuch-Braddon M, Gillam I, Telford RD, Weidemann MJ. Changes in the susceptibility of red blood cells to oxidative and osmotic stress following submaximal exercise.
Eur J Appl Physiol Occup Physiol 1995, 70, 5, 427-436.
106. Statuta SM, Asif IM, Drezner JA. Relative energy deficiency in sport (RED-S). Br J Sports Med 2017, 51, 21, 1570-1571.
107. Steensberg A, Febbraio MA, Osada T, Schjerling P, van Hall G, Saltin B. Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol 2001, 537, 633-639.
108. Stewart JG, Ahlquist DA, McGill DB, Ilstrup DM, Schwartz S, Owen RA. Gastrointestinal blood loss and anemia in runners. Ann Intern Med 1984, 100, 843-845.
109. Takahashi H, Kamei A, Osawa T, Kawahara T, Takizawa O, Maruyama K. 13C MRS reveals a small diurnal variation in the glycogen content of human thigh muscle. NMR Biomed 2015, 28, 650-655.
110. Takami T, Sakaida I. Iron regulation by hepatocytes and free radicals. J Clin Biochem Nutr 2011, 48, 103-106.
111. Thomas DT, Erdman KA, Burke LM. Nutrition and athletic performance. Med Sci Sport Exerc 2016, 4, 543-568.
112. Torstveit MK, Sundgot-Borgen J. The female athlete triad: Are elite athletes at increased risk?
Med Sci Sport Exerc 2005, 37, 184-193.
113. Vecchi C, Montosi G, Garuti C, Corradini E, Sabelli M, Canali S. Gluconeogenic signals regulate iron homeostasis via hepcidin in mice. Gastroenterology 2014, 146, 1060-1069.
98
114. Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR, Kuijper JL. Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. J Clin Endocrinol Metab 1997, 82, 2, 561-565.
115. Woods AL, Garvican-Lewis LA, Lundy B, Rice AJ, Thompson KG. New approaches to determine fatigue in elite athletes during intensified training: Resting metabolic rate and pacing profile. PLoS One 2017, 12, e0173807.
116. Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006, 108, 9, 3204-3209.
117. Zhang AS, Enns CA. Iron homeostasis: recently identified proteins provide insight into novel control mechanisms. J Biol Chem 2009, 284, 711-715.
118. Ziemann E, Kasprowicz K, Kasperska A, Zembroń-Lacny A, Antosiewicz J, Laskowski R. Do high blood hepcidin concentrations contribute to low ferritin levels in young tennis players at the end of tournament season? J Sports Sci Med 2013, 12, 249-258.
119. Zotter H, Robinson N, Zorzoli M, Schattenberg L, Saugy M, Mangin P. Abnormally high serum ferritin levels among professional road cyclists. Br J Sports Med 2004, 38, 704-708.
120. ⼩清⽔孝⼦, 柳沢⾹絵, 樋⼝満. スポーツ選⼿の推定エネルギー必要量 (特集 スポー
ツにおける⾷事・栄養の役割と意義). トレーニング科学 2005, 17, 245-250.
121. 村上美絵, 押⽅玲⾹, 宮本徳⼦, 岸⽥玲奈, 永⽥純美, 寺澤洋⼦,今村裕⾏. ⾷事記録法
における調査⽇設定の妥当性について. 総合健診 2010, 37, 3, 405-413.
99