50
51
(7) 新開省二. 高齢者と身体活動. 日本臨床, 58 : 302-306. 2000.
(8) Coats, A. J., Clark, A. L., Piepoli, M., Volterrani, M., & Poole-Wilson, P. A.
Symptoms and quality of life in heart failure: the muscle hypothesis. British Heart Journal, 72 : S36-39. 1994.
(9) 総務省統計局: e-Stat 社会医療診療行為別統計 (厚生労働省).
(https://www.e-stat.go.jp/SG1/estat/GL08020101.do?_toGL08020101_&tstatCode=000001029602)
(参照日2016年12月5日)
(10) Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F.,
Martin, F. C., Michel, JP., Rolland, Y., Schneider, S. M., Topinková, E.,
Vandewoude, M., & Zamboni M. Sarcopenia: European consensus on definition
and diagnosis Report of the European Working Group on Sarcopenia in Older
People. Age and Ageing, 39: 412-423. 2010
(11) Vescovo, G., Ambrosio, G. B., & Libera, L. D. Apoptosis and changes in contractile
protein pattern in the skeletal muscle in heart failure. Acta physiologica
Scandinavica, 171: 305-310. 2001.
52
(12) Fülster, S., Tacke, M., Sandek, A., Ebner, N., Tschöpe, C., Doehner, W., Anker, S.
D., & Von Haehling, S. Muscle wasting in patients with chronic heart failure:
results from the studies investigating co-morbidities aggravating heart failure
(SICA-HF). European Heart Journal, 34: 512-519. 2012.
(13) Krown, K. A., Page, M. T., Nguyen, C., Zechner, D., Gutierrez, V., Comstock, K. L.,
Glembotski, C. C., & Sabbadini, R. A. Tumor necrosis factor alpha-induced
apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in
cardiac cell death. Journal of Clinical Investigation, 98: 2854-2865. 1996.
(14) 谷本芳美, 渡辺美鈴, 河野 令, 広田千賀, 高崎恭輔, 河野公一. 日本人筋肉量の加齢に
よる特徴. 日本老年医学会雑誌, 47: 52-57. 2010.
(15) 森尾裕志, 井澤和大, 渡辺敏, 平木幸治, 笠原酉介, 長田尚彦, 大宮一人, 川間健之介.
心大血管疾患患者における退院時年齢・性別の運動機能指標について. 心臓リハビリ
テーション, 14: 89-93. 2009.
53
(16) Clark, A. L., Poole-Wilson, P. A., & Coats, A. J.: Exercise limitation in chronic heart
failure: central role of the periphery. Journal of the American College of
Cardiology, 28: 1092-1102. 1996
(17) 森尾裕志, 井澤和大, 渡辺敏, . 平木幸治, 田中彩乃, 笠原酉介, 武市尚也, 長田尚彦,
大宮一人, 三宅良彦, 川間健之介. 心疾患患者における運動耐容能に関わる運動機能指
標の相互関係について―高齢群および壮年群での検討―. 心臓リハビリテーション13:
299-303. 2008.
(18) 山本周平, 松永篤彦, 石井玲, 松本卓也, 堀田一樹, 清水良祐, 鈴木秀俊, 松嶋真哉, 神
谷健太郎, 見井戸和正, 高橋由美, 河野真理, 増田卓, 和泉徹. 入院期高齢虚血性心疾
患患者は骨格筋筋力に加えてバランス機能も低下している. 日本循環器病予防学会誌,
45: 1-8. 2010.
(19) 根本慎司, 松永篤彦, 山本周平, 亀川大輔, 松沢良太, 阿部義史, 高橋佑太, 林祐介, 室
内直樹, 若梅一樹, 木村雅彦, 神谷健太郎, 見井田和正, 野田千春, 東條美奈子, 増田
卓, 和泉徹. 高齢虚血性心疾患患者の退院後の身体活動強度は下肢筋力だけでなくバ
54
ランス機能の影響を受けている. 心臓リハビリテーション17: 98-102. 2012.
(20) Rubenstein, L. Z. Falls in older people: epidemiology, risk factors and strategies for
prevention. Age and Ageing, 35: ii37-ii41. 2006.
(21) Yamada, M., Nishiguchi, S., Fukutani, N., Tanigawa, T., Yukutake, T., Kayama, H.,
Aoyama, T., & Arai, H. Prevalence of sarcopenia in community-dwelling Japanese
older adults. Journal of the American Medical Directors Association, 14: 911-915.
2013.
(22) Lawlor, D. A., Patel, R., & Ebrahim, S. Association between falls in elderly women
and chronic diseases and drug use: cross sectional study. British Medical Journal,
327: 712-717. 2003.
(23) 荒井秀典. フレイルの意義. 日本老年医学会雑誌, 51: 497-501. 2014.
(24) Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J.,
Seeman, T., Tracy, R,. Kop, W.J., Burke, G., & McBurnie, M. A. Frailty in older
adults evidence for a phenotype. The Journals of Gerontology Series A: Biological
55
Sciences and Medical Sciences, 56: M146-M157. 2001.
(25) Pasini E, Aquilani R, Testa C, Baiardi P, Angioletti S, Boschi F, Verri M, Dioguardi
F. Pathogenic gut flora in patients with chronic heart failure. Journal of the
American College of Cardiology: Heart Failure, 4: 220-227. 2016.
(26) Blaum, C. S., Xue, Q. L., Tian, J., Semba, R. D., Fried, L. P., & Walston, J. Is
hyperglycemia associated with frailty status in older women?. Journal of the
American Geriatrics Society, 57: 840-847. 2009.
(27) Leng, S. X., Tian, X., Matteini, A., Li, H., Hughes, J., Jain, A., Walston, J. D., &
Fedarko, N. S. IL-6-independent association of elevated serum neopterin levels
with prevalent frailty in community-dwelling older adults. Age and Ageing, 40:
475-481. 2011.
(28) 山田純生, 神谷訓康, 足立拓史. 心不全リハビリテーションにおけるフレイルを考え
る. 心臓リハビリテーション, 22: 4-7. 2016.
56
(29) Madan, S. A., Fida, N., Barman, P.,Sims, D., Shin, J., . Verghese, J., Piña, I., Jorde,
U., & Patel, S.R. Frailty Assessment in Advanced Heart Failure. Journal of
Cardiac Failure, 1–5. 2016.
(30) Salinas, G. L. A., Fernández, M. S., Izco, M. P., del Castillo, Á. M., Díaz, L. M. R.,
Granero, C. L., Gómez, M. V., Pueyo, P. P., Martín, D. V., Sanz, A. P., Ruiz, J. M. M.,
Recio-Mayoral, A., Salvador Ramos, L. S., Martín, D. M., López, A. C., Mena, M. J.,
& Gómez, J. L. Z. Frailty predicts major bleeding within 30days in elderly patients
with acute coronary syndrome. International Journal of Cardiology, 222: 590-593.
2016.
(31) Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Jimenez-Sosa, A., Gonzalez, J.,
Caballero-Estevez, N., Martín-Casañas, F. V., Lara-Padron, A., & Aranda Jr, J. M.
The impact of frailty in older patients with non-ischaemic cardiomyopathy after
implantation of cardiac resynchronization therapy defibrillator. Europace, 17: 598–
602. 2015.
57
(32) Kang, L., Zhang, S. Y., Zhu, W. L., Pang, H. Y., Zhang, L., Zhu, M. L., Liu, X. H. &
Liu, Y. T. Is frailty associated with short-term outcomes for elderly patients with
acute coronary syndrome? Journal of Geriatric Cardiology, 12: 662–667. 2015.
(33) Pulignano, G., Del Sindaco, D., Di Lenarda, A., Alunni, G., Senni, M., Tarantini, L.,
Cioffi, G., Tinti, M.D., Barbati, G., Minardi, G., Uguccioni, M., IMAGE-HF Study
Investigators, Gaschino, G., Tarantini, L., Cioffi, G., Di Lenarda, A., Russo, G.,
Radini, D., Stellato, K., Senni, M., Alunni, G., Murrone, A., Zuchi, C., Pulignano,
G., Del Sindaco, D., Tolone, S., Tinti, M.D., Monzo, L., Minardi, G., & Uguccioni, M.
Incremental Value of Gait Speed in Predicting Prognosis of Older Adults With
Heart Failure. Insights From the IMAGE-HF Study. Journal of the American
College of Cardiology: Heart Failure, 4. 2015.
(34) Sergi, G., Veronese, N., Fontana, L., De Rui, M., Bolzetta, F., Zambon, S., ... Corti,
MC., Baggio, G., Toffanello, E. D., Crepaldi, G., Perissinotto, E., & Manzato, E.
Pre-frailty and risk of cardiovascular disease in elderly men and women: The
58
Pro.V.A. Study. Journal of the American College of Cardiology, 65: 976–983. 2015.
(35) Khan, H., Kalogeropoulos, A. P., Georgiopoulou, V. V., Newman, A. B., Harris, T. B.,
Rodondi, N., Bauer, D. C., Kritchevsky, S. B., & Butler, J. Frailty and risk for heart
failure in older adults: The health, aging, and body composition study. American
Heart Journal, 166: 887–894. 2013.
(36) Matsuzawa, Y., Konishi, M., Akiyama, E., Suzuki, H., Nakayama, N., Kiyokuni,
M., Sumita, S., Ebina, T., Kosuge, M., Hibi, K., Tsukahara, K., Iwahashi, N., Endo,
M., Maejima, N., Saka, K., Hashiba, K., Okada, K., Taguri, M., Morita, S.,
Sugiyama, S., Ogawa, H., Sashika, H., Umemura, S., & Kimura, K. Association
between gait speed as a measure of frailty and risk of cardiovascular events after
myocardial infarction. Journal of the American College of Cardiology, 61: 1964–
1972. 2013.
(37) Newman, A. B., Gottdiener, J. S., McBurnie, M. A., Hirsch, C. H., Kop, W. J., Tracy,
R., Walston, J. D., & Fried, L. P. Associations of subclinical cardiovascular disease
59
with frailty. The Journals of Gerontology Series A: Biological Sciences and Medical
Sciences, 56: M158-M166. 2001.
(38) Afilalo, J., Karunananthan, S., Eisenberg, M. J., Alexander, K. P., & Bergman, H.
Role of Frailty in Patients With Cardiovascular Disease. American Journal of
Cardiology, 103: 1616–1621. 2009.
(39) Singh, M., Rihal, C. S., Lennon, R. J., Spertus, J. A., Nair, K. S., & Roger, V. L.
Influence of frailty and health status on outcomes in patients with coronary
disease undergoing percutaneous revascularization. Circulation: Cardiovascular
Quality and Outcomes, 4: 496–502. 2011.
(40) Clinical Trials. gov. (A service of the U.S. National Institutes of Health):
SILVER-AMI: Outcomes in Older Persons With Heart Attacks (SILVER-AMI) .
(https://clinicaltrials.gov/ct2/show/NCT01755052) (参照日2016年12月5日)
(41) Suzukamo, Y., Fukuhara, S., Green, J., Kosinski, M., Gandek, B., & Ware, J. E.
Validation testing of a three-component model of Short Form-36 scores. Journal of
60
Clinical Epidemiology, 64: 301-308. 2011.(42) Berg, K. O., Wood-Dauphinee, S. L., Williams, J. I., & Maki, B. Measuring balance
in the elderly: validation of an instrument. Canadian Journal of Public Health, 83:
7-11. 1992.
(43) Panel on Prevention of Falls in Older Persons, American Geriatrics Society and
British Geriatrics Society. Summary of the updated American Geriatrics
Society/British Geriatrics Society clinical practice guideline for prevention of falls
in older persons. Journal of the American Geriatrics Society, 59: 148-157. 2011.
(44) 望月久, 金子誠喜. 臨床的バランス能力評価指標に関するアンケート調査報告. 理学療
法科学 24: 205-213. 2009.
(45) ATS statement: Guidelines for the Six-Minute Walk Test. American Journal of
Respiratory and Critical Care Medicine, 166: 111-117. 2002.
(46) 日本循環器学会: 慢性心不全治療ガイドライン (2010年改訂版).
http://www.j-circ.or.jp/guideline/pdf/JCS2010_matsuzaki_h.pdf (参照日2016年12月5日)
61
(47) ATS Statement: guidelines for the six-minute walk test. ATS Committee on
Proficiency Standards for Clinical Pulmonary Function Laboratories. American
Journal of Respiratory and Critical Care Medicine, 166: 111-117. 2002.
(48) Rubenstein, L. Z. Falls in older people: epidemiology, risk factors and strategies for
prevention. Age and Ageing 35: ii37-ii41. 2006.
(49) Cahalin, L. P., Mathier, M. A., Semigran, M. J., Dec, G. W., & DiSalvo, T. G. The
six-minute walk test predicts peak oxygen uptake and survival in patients with
advanced heart failure. Chest,110: 325-332. 1996.
(50) 鳥羽 研二, 大河内 二郎, 高橋 泰, 松林 公蔵, 西永 正典, 山田 思鶴, 高橋 龍太郎,
西島 令子, 小林 義雄, 町田 綾子, 秋下 雅弘, 佐々木 英忠. 転倒リスク予測のための
「転倒スコア」の開発と妥当性の検証. 日本老年医学会雑誌 42: 346-352. 2005.
(51) Lin, C. C., Li, C. I., Chang, C. K., Liu, C. S., Lin, C. H., Meng, N. H., Lee, Y. D.,
Chen, F. N., & Li, T. C. Reduced Health-Related Quality of Life in Elders with
Frailty: A Cross-Sectional Study of Community-Dwelling Elders in Taiwan. PLoS
62
ONE, 6: e21841. 2011.(52) Buck HG., & Riegel B. The impact of frailty on health related quality of life in
heart failure. European Journal of Cardiovascular Nursing, 10:159-66. 2011.
(53) Uchmanowicz, I., & Gobbens, R. J. The relationship between frailty, anxiety and
depression, and health-related quality of life in elderly patients with heart failure.
Clinical Interventions in Aging, 10: 1595-1600. 2015.
(54) Ware JE Jr, & Sherbourne CD. The MOS 36-item short- form health survey
(SF-36), Ⅰ. Conceptual framework and item selection. Medical care, 30: 473-483. 1992.
(55) 厚生労働省: 介護予防マニュアル(改訂版:平成24年3月)
(http://www.mhlw.go.jp/topics/2009/05/tp0501-1.html) (参照日2018年8月15
日).
(56) Ogawa, K., Fujiwara, Y., Yoshida, H., Nishi, M., Fukaya, T., Kim, M., Amono, H.,
Watanabe, N., & Shinkai, S. The validity of the “Kihon Check-list” as an index of
frailty and its biomarkers and inflammatory markers in elderly people. Nihon
63
Ronen Igakkai zasshi. Japanese journal of geriatrics, 48: 545-552. 2011.
(57) Fukuhara, S., Bito, S., Green, J., Hsiao, A., & Kurokawa, K. Translation,
adaptation, and validation of the SF-36 Health Survey for use in Japan. Journal of
clinical epidemiology, 51: 1037-1044. 1998.
(58) Fukuhara, S., Ware Jr, J. E., Kosinski, M., Wada, S., & Gandek, B. Psychometric
and clinical tests of validity of the Japanese SF-36 health survey. Journal of
clinical epidemiology, 51: 1045-1053. 1998.
(59) Fukuhara S, Suzukamo Y. Manual of SF-36v2 Japanese version 2004, iHope
International Inc., Kyoto. 2015.
(60) 新井龍, 木庭新治, 下司映一. 急性冠症候群患者に対する心臓リハビリテーションによ
る運動耐容能と主観的健康観の改善は関連しない. 心臓リハビリテーション 23:
39-45. 2017.
(61) STRAUSS, Anselm L. Chronic illness and the quality of life, 南裕子 (訳): 慢性疾患
を生きる-ケアとクオリティ・ライフの接点. 医学書院, 東京. 248. 1987.
64
(62) Laura Lorenzo-López, Rocío López-López, Ana Maseda, Ana Buján, José L.
Rodríguez-Villamil, José C. Millán-Calenti. Changes in frailty status in a
community-dwelling cohort of older adults: The VERISAÚDE study. Maturitas,
119: 54–60. 2019.