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士に心から厚く感謝の意を表します．本研究ならびに私の米国生活に際し，終始御指導と御鞭達を賜り，また本稿作製に あたり有益なる御助言と御校閲を賜りました，CalifbmiaPacificMedicalResea1℃hCenter InstituteのDieterCGmenert博士に心から厚く感謝の意を表します．
本 論 文 作 製 に 際 し ， 有 益 な る 御 助 言 と 御 校 閲 を 賜 り ま し た 熊 本 大 学 大 学 院 医 学 薬 学 研 究 部 高 演 和 夫 教 授 に 厚 く 御 礼 申 し 上 げ ま す ．
本 論 文 作 製 に 際 し ， 有 益 な る 御 助 言 と 御 校 閲 を 賜 り ま し た 熊 本 大 学 大 学 院 医 学 薬 学 研 究 部 佐 藤 圭 創 助 教 授 に 厚 く 御 礼 申 し 上 げ ま す ．
本 研 究 に 際 し ， 大 学 院 修 士 課 程 に お け る 御 指 導 と 御 鞭 達 を 賜 り ， 多 く の 面 で 御 世 話 に な り ま し た 熊 本 大 学 大 学 院 医 学 薬 学 研 究 部 宮 田 健 教 授 に 深 く 感 謝 の 意 を 表 し ま す．
本 研 究 に 際 し ， 終 始 愛 情 惜 し ま ぬ 激 励 を 賜 り ， 英 語 校 正 に お い て 多 大 な る 御 援 助 を
戴きましたMaryAnnSotenSuico助手に心から感謝の意を表します．
本 研 究 な ら び に 私 の 渡 米 に 際 し ， 終 始 御 指 導 と 御 鞭 達 を 賜 り ， 多 く の 面 で 御 世 話 に な り ま し た 礎 演 洋 一 郎 助 教 授 お よ び 有 馬 英 俊 助 教 授 に 深 謝 致 し ま す ．
共 同 研 究 者 と し て ご 協 力 い た だ い た ， 城 野 博 史 ， 今 里 暁 ， 沖 米 田 司 の 各 博 士 ， 古 田 貴 志 ， 森 陽 子 ， 加 藤 浩 亮 の 各 修 士 ， 大 庭 真 理 子 学 士 ， ま た ， 学 外 共 同
研究者としてご協力いただいたHai‑dongXu，BeinanWang，JiahuaiHan，Xin‑XingGu，
TimothyFMurphy，ＤａｖｉｄＪ・Ｌｉｍ，AkihimSaki，TakahiroWatanabe，DavidaD・Rixter，
AliAndalibi，FredLinthicum，Yue‑LingGuan，ＡｎｄｒｅｗＣＢ・Ｃａｔｏ，ShizuoAkima，
SuganyaViriyakosol，JudyCheung，AkikoUeham諸氏に心より感謝致します．