3 章，4 章にて培養された小さな脳が培養皿上で短期的な記憶を実現しうることを示 した．分散培養系がシナプス可塑性を発現する実験系であることとあわせて考えると，
脳で起きている短期的な記憶を長期的な記憶に転換する機構も存在する可能性があり，
興味深い．脳のように複雑な入出力系を持つ系のメカニズムを解明するには，脳に近い ダイナミクスを保有し，かつ実験パラメーターを詳細に解析しうる系を用いて実験を行 う必要がある．この意味で，分散培養系にセンサ-を備えた小型ロボットを接続し，入 出力を付与するニューロ・ロボットは，脳において起こっているであろう外界と回路網 のインタラクションによる行動生成アルゴリズムの自律獲得と自律行動の発現をモデ ル化する[137]．つまり，小さな脳のモデルを培養皿上に構築する試みである．また，
脳の高次機能の特徴を再現する系を構築すれば，脳の高次機能への化学物質の薬理的効 果を解析する有効な系が構築できると考えられる．
参考文献
132
参考文献
[1] E. R. Kandel, J. H. Schwartz, T. M. Jessell, S. A. Siegelbaum, and A. J. Hudspeth, Principles of Neural Science, Fifth Edition, New York City: McGraw-Hill Professional, 2012.
[2] J. G. Nicholls, From Neuron to Brain: Sinauer Associates, 2012.
[3] T. V. Bliss, and T. Lomo, “Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path,”
J Physiol, vol. 232, no. 2, pp. 331-56, 1973.
[4] M. Ito, “The molecular organization of cerebellar long-term depression,” Nat Rev Neurosci, vol. 3, no. 11, pp. 896-902, 2002.
[5] S. Song, K. D. Miller, and L. F. Abbott, “Competitive Hebbian learning through spike-timing-dependent synaptic plasticity,” Nat Neurosci, vol. 3, pp. 919-26, 2000.
[6] G. Bi, and M. Poo, “Synaptic modification by correlated activity: Hebb's postulate revisited,” Annu Rev Neurosci, vol. 24, pp. 139-66, 2001.
[7] W. F. Borschel, J. M. Myers, E. M. Kasperek, T. P. Smith, N. M. Graziane, L. M.
Nowak, and G. K. Popescu, “Gating reaction mechanism of neuronal NMDA receptors,” J Neurophysiol, vol. 108, no. 11, pp. 3105-15, 2012.
[8] G. Capocchi, M. Zampolini, and J. Larson, “Theta burst stimulation is optimal for induction of LTP at both apical and basal dendritic synapses on hippocampal CA1 neurons,” Brain Res, vol. 591, no. 2, pp. 332-6, 1992.
[9] J. M. Montgomery, P. Pavlidis, and D. V. Madison, “Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation,”
Neuron, vol. 29, no. 3, pp. 691-701, 2001.
[10] T. V. Bliss, and G. L. Collingridge, “A synaptic model of memory: long-term potentiation in the hippocampus,” Nature, vol. 361, no. 6407, pp. 31-9, 1993.
[11] E. R. Kandel, “The molecular biology of memory storage: a dialogue between genes and synapses,” Science, vol. 294, no. 5544, pp. 1030-8, 2001.
[12] K. Tominaga-Yoshino, S. Kondo, S. Tamotsu, and A. Ogura, “Repetitive activation of protein kinase A induces slow and persistent potentiation associated with synaptogenesis in cultured hippocampus,” Neurosci Res, vol. 44, no. 4, pp. 357-67, 2002.
[13] T. Urakubo, A. Ogura, and K. Tominaga-Yoshino, “Ultrastructural features of hippocampal CA1 synapses with respect to synaptic enhancement following repeated PKA activation,” Neurosci Lett, vol. 407, no. 1, pp. 1-5, 2006.
[14] K. Tominaga-Yoshino, T. Urakubo, M. Okada, H. Matsuda, and A. Ogura, “Repetitive
参考文献
133
induction of late-phase LTP produces long-lasting synaptic enhancement accompanied by synaptogenesis in cultured hippocampal slices,” Hippocampus, vol.
18, no. 3, pp. 281-93, 2008.
[15] Y. Shinoda, Y. Kamikubo, Y. Egashira, K. Tominaga-Yoshino, and A. Ogura,
“Repetition of mGluR-dependent LTD causes slowly developing persistent reduction in synaptic strength accompanied by synapse elimination,” Brain Res, vol. 1042, no.
1, pp. 99-107, 2005.
[16] Y. Kamikubo, Y. Egashira, T. Tanaka, Y. Shinoda, K. Tominaga-Yoshino, and A.
Ogura, “Long-lasting synaptic loss after repeated induction of LTD: independence to the means of LTD induction,” Eur J Neurosci, vol. 24, no. 6, pp. 1606-16, 2006.
[17] Y. Egashira, T. Tanaka, P. Soni, S. Sakuragi, K. Tominaga-Yoshino, and A. Ogura,
“Involvement of the p75(NTR) signaling pathway in persistent synaptic suppression coupled with synapse elimination following repeated long-term depression induction,” J Neurosci Res, vol. 88, no. 16, pp. 3433-46, 2010.
[18] J. Z. Tsien, P. T. Huerta, and S. Tonegawa, “The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory,” Cell, vol. 87, no. 7, pp. 1327-38, 1996.
[19] T. J. McHugh, K. I. Blum, J. Z. Tsien, S. Tonegawa, and M. A. Wilson, “Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice,” Cell, vol. 87, no. 7, pp. 1339-49, 1996.
[20] C. G. Gross, “Genealogy of the "grandmother cell",” Neuroscientist, vol. 8, no. 5, pp.
512-8, 2002.
[21] D. O. Hebb, The Organization of Behavior, New York: Wiley, 1949.
[22] K. Tsunoda, Y. Yamane, M. Nishizaki, and M. Tanifuji, “Complex objects are represented in macaque inferotemporal cortex by the combination of feature columns,” Nat Neurosci, vol. 4, no. 8, pp. 832-8, 2001.
[23] O. Fukayama, H. Otsuka, R. Hashimoto, T. Suzuki, and K. Mabuchi, “Development of exoskeletal robotic limbs for a rat controlled by neural signals based on a vehicular neuro-robotic platform RatCar,” Conf Proc IEEE Eng Med Biol Soc, vol.
2012, pp. 1707-10, 2012.
[24] H. P. Robinson, M. Kawahara, Y. Jimbo, K. Torimitsu, Y. Kuroda, and A. Kawana,
“Periodic synchronized bursting and intracellular calcium transients elicited by low magnesium in cultured cortical neurons,” J Neurophysiol, vol. 70, no. 4, pp. 1606-16, 1993.
[25] W. S. McCulloch, and W. Pitts, “A logical calculus of the ideas immanent in nervous activity. 1943,” Bull Math Biol, vol. 52, no. 1-2, pp. 99-115; discussion 73-97, 1990.
参考文献
134
[26] F. Rosenblatt, “The perceptron: a probabilistic model for information storage and organization in the brain,” Psychol Rev, vol. 65, no. 6, pp. 386-408, 1958.
[27] M. L. Minsky, and S. Papert, Perceptrons; an Introduction to Computational Geometry: MIT Press, 1969.
[28] 中野磬, アソシアトロン: 連想記憶のモデルと知的情報処理: 昭晃堂, 1979.
[29] D. H. Ackley, G. E. Hinton, and T. J. Sejnowski, “A learning algorithm for boltzmann machines,” Cognitive Science, vol. 9, no. 1, pp. 147-169, 1985.
[30] T. Kohonen, Self-Organizing Maps: Springer Berlin Heidelberg, 2001.
[31] L. A. Zadeh, “Fuzzy sets,” Information and Control, vol. 8, no. 3, pp. 338-353, 1965.
[32] L. A. Zadeh, “Fuzzy algorithms,” Information and Control, vol. 12, no. 2, pp. 94-102, 1968.
[33] E. H. Mamdani, and S. Assilian, “An experiment in linguistic synthesis with a fuzzy logic controller,” International Journal of Man-Machine Studies, vol. 7, no. 1, pp.
1-13, 1975.
[34] J. H. Holland, Adaptation in natural and artificial systems: MIT Press, 1992.
[35] A. M. Turing, “Computing Machinery and Intelligence,” Mind, vol. LIX, no. 236, pp.
433-460, 1950.
[36] “Computer chatbot 'Eugene Goostman' passes the Turing test,”
http://www.princetonai.com/bot/bot.jsp, 2014.
[37] M. Mike, “No, A 'Supercomputer' Did NOT Pass The Turing Test for the First Time And Everyone Should Know Better,” Techdirt. Retrieved 2014.
[38] J. R. Searle, Minds, brains, and programs: MIT Press, 1985.
[39] R. A. Brooks, “A robot that walks; emergent behaviors from a carefully evolved network,” 1989.
[40] F. Kaplan, “Neurorobotics: an experimental science of embodiment,” Frontiers in Neuroscience, vol. 2, 2008.
[41] Z. C. Chao, D. J. Bakkum, D. A. Wagenaar, and S. M. Potter, “Effects of Random External Background Stimulation on Network Synaptic Stability After Tetanization:
A Modeling Study,” Neuroinformatics, vol. 3, no. 3, pp. 263-280, 2005.
[42] D. J. Bakkum, A. C. Shkolnik, G. Ben-Ary, P. Gamblen, T. B. DeMarse, and S. M.
Potter, “Removing some ‘A’ from AI: Embodied Cultured Networks. ,” Embodied Artificial Intelligence, pp. 130-145, 2004.
[43] J. Tessadori, M. Bisio, S. Martinoia, and M. Chiappalone, “Modular neuronal assemblies embodied in a closed-loop environment: toward future integration of brains and machines,” Front Neural Circuits, vol. 6, pp. 99, 2012.
[44] 伊東嗣功, 工藤卓, “培養神経回路網における誘発応答パターンの履歴現象,”電気学会
参考文献
135
論文誌Ｃ（電子・情報・システム部門誌）, vol. 133, no. 10, pp. 1905-1911, 2013.
[45] G. Shahaf, and S. Marom, “Learning in networks of cortical neurons,” J Neurosci, vol.
21, no. 22, pp. 8782-8, 2001.
[46] G. Sumbre, A. Muto, H. Baier, and M.-m. Poo, “Entrained rhythmic activities of neuronal ensembles as perceptual memory of time interval,” Nature, vol. 456, no.
7218, pp. 102-106, 11/06/print, 2008.
[47] D. A. Stenger, G. W. Gross, E. W. Keefer, K. M. Shaffer, J. D. Andreadis, W. Ma, and J.
J. Pancrazio, “Detection of physiologically active compounds using cell-based biosensors,” Trends Biotechnol, vol. 19, no. 8, pp. 304-9, 2001.
[48] M. Parviz, and G. W. Gross, “Quantification of zinc toxicity using neuronal networks on microelectrode arrays,” Neurotoxicology, vol. 28, no. 3, pp. 520-31, 2007.
[49] R. D. Fields, and B. Stevens-Graham, “New insights into neuron-glia communication,” Science, vol. 298, no. 5593, pp. 556-62 , 2002.
[50] D. E. Baranano, C. D. Ferris, and S. H. Snyder, “Atypical neural messengers,”
Trends Neurosci, vol. 24, no. 2, pp. 99-106, 2001.
[51] A. Araque, R. P. Sanzgiri, V. Parpura, and P. G. Haydon, “Calcium elevation in astrocytes causes an NMDA receptor-dependent increase in the frequency of miniature synaptic currents in cultured hippocampal neurons,” J Neurosci, vol. 18, no. 17, pp. 6822-9, 1998.
[52] R. J. Mullen, C. R. Buck, and A. M. Smith, “NeuN, a neuronal specific nuclear protein in vertebrates,” Development, vol. 116, no. 1, pp. 201-11, 1992.
[53] P. M. Wood, and R. P. Bunge, “The origin of remyelinating cells in the adult central nervous system: the role of the mature oligodendrocyte,” Glia, vol. 4, no. 2, pp.
225-32, 1991.
[54] J. Schnitzer, and M. Schachner, “Developmental expression of cell type-specific markers in mouse cerebellar cells in vitro,” J Neuroimmunol, vol. 1, no. 4, pp. 471-87, 1981.
[55] D. Ito, Y. Imai, K. Ohsawa, K. Nakajima, Y. Fukuuchi, and S. Kohsaka,
“Microglia-specific localisation of a novel calcium binding protein, Iba1,” Brain Res Mol Brain Res, vol. 57, no. 1, pp. 1-9, 1998.
[56] M. Papa, M. C. Bundman, V. Greenberger, and M. Segal, “Morphological analysis of dendritic spine development in primary cultures of hippocampal neurons,” J Neurosci, vol. 15, no. 1 Pt 1, pp. 1-11, 1995.
[57] G. Grosse, R. Tapp, M. Wartenberg, H. Sauer, P. A. Fox, J. Grosse, M. Gratzl, and M.
Bergmann, “Prenatal hippocampal granule cells in primary cell culture form mossy fiber boutons at pyramidal cell dendrites,” J Neurosci Res, vol. 51, no. 5, pp. 602-11,
参考文献
136 1998.
[58] M. Ballini, J. Muller, P. Livi, C. Yihui, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I.
Lloyd Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, G. Wei, M. Fiscella, D.
J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” Solid-State Circuits, IEEE Journal of, vol. 49, no. 11, pp. 2705-2719, 2014.
[59] Y. Jimbo, T. Tateno, and H. P. Robinson, “Simultaneous induction of pathway-specific potentiation and depression in networks of cortical neurons,”
Biophys J, vol. 76, no. 2, pp. 670-8, 1999.
[60] S. N. Kudoh, C. Hosokawa, A. Kiyohara, T. Taguchi, and I. Hayashi, “Biomodeling system-interaction between living neuronal networks and the outer world,” Journal of Robotics and Mechatronics, vol. 19, no. 5, pp. 592, 2007.
[61] O. Levy, N. E. Ziv, and S. Marom, “Enhancement of neural representation capacity by modular architecture in networks of cortical neurons,” Eur J Neurosci, vol. 35, no.
11, pp. 1753-60, 2012.
[62] S. N. Kudoh, A. Kiyohara, and T. Taguchi, “The Heterogenous Distribution of the Functional Synaptic Connections in a Rat Hippocampal Dissociated Neurons,” IEEJ Transactions on Electronics, Information and Systems, vol. 127, pp. 1611-1618, 2007.
[63] M. Chiappalone, M. Bove, A. Vato, M. Tedesco, and S. Martinoia, “Dissociated cortical networks show spontaneously correlated activity patterns during in vitro development,” Brain Res, vol. 1093, no. 1, pp. 41-53, 2006.
[64] 清原藍, 田口隆久, 工藤卓, “分散培養系における自発性活動電位と誘導活動電位との関
係性,”電気学会論文誌Ｃ（電子・情報・システム部門誌）, vol. 129, no. 10, pp. 1815-1821, 2009.
[65] M. Murata, H. Ito, T. Taenaka, and S. N. Kudoh, "Modification of activity pattern induced by synaptic enhancements in a semi-artificial network of living neurons." pp.
250-254.
[66] G. Banker, and K. Goslin, Culturing Nerve Cells: MIT Press, 1998.
[67] T. Seki, T. Namba, H. Mochizuki, and M. Onodera, “Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus,” J Comp Neurol, vol. 502, no. 2, pp. 275-90, 2007.
[68] S. J. Bertrand, M. V. Aksenova, M. Y. Aksenov, C. F. Mactutus, and R. M. Booze,
“Endogenous amyloidogenesis in long-term rat hippocampal cell cultures,” BMC Neurosci, vol. 12, pp. 38, 2011.
[69] Y. Takatsuru, K. Eto, R. Kaneko, H. Masuda, N. Shimokawa, N. Koibuchi, and J.
参考文献
137
Nabekura, “Critical role of the astrocyte for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke,” J Neurosci, vol. 33, no. 11, pp.
4683-92, 2013.
[70] D. Ito, H. Tamate, M. Nagayama, T. Uchida, S. N. Kudoh, and K. Gohara, “Minimum neuron density for synchronized bursts in a rat cortical culture on multi-electrode arrays,” Neuroscience, vol. 171, no. 1, pp. 50-61, 2010.
[71] J. van Pelt, P. S. Wolters, M. A. Corner, W. L. Rutten, and G. J. Ramakers,
“Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks,” IEEE Trans Biomed Eng, vol. 51, no. 11, pp. 2051-62, 2004.
[72] J. Pu, H. Gong, X. Li, and Q. Luo, “Developing neuronal networks: self-organized criticality predicts the future,” Sci Rep, vol. 3, pp. 1081, 2013.
[73] W. Chen, X. Li, J. Pu, and Q. Luo, “Spatial-temporal dynamics of chaotic behavior in cultured hippocampal networks,” Phys Rev E Stat Nonlin Soft Matter Phys, vol. 81, no. 6 Pt 1, pp. 061903, 2010.
[74] R. Madhavan, Z. C. Chao, and S. M. Potter, “Plasticity of recurring spatiotemporal activity patterns in cortical networks,” Phys Biol, vol. 4, no. 3, pp. 181-93, 2007.
[75] A. Usami, N. Matsuki, and Y. Ikegaya, “Spontaneous plasticity of multineuronal activity patterns in activated hippocampal networks,” Neural Plast, vol. 2008, pp.
108969, 2008.
[76] S. N. Kudoh, A. Matsuo, K. Kiyosue, M. Kasai, and T. Taguchi, “Long-lasting enhancement of synaptic activity in dissociated cerebral neurons induced by brief exposure to Mg2+-free conditions,” Neurosci Res, vol. 28, no. 4, pp. 337-44, 1997.
[77] Y. Wang, N. J. Haughey, M. P. Mattson, and K. Furukawa, “Dual effects of ATP on rat hippocampal synaptic plasticity,” Neuroreport, vol. 15, no. 4, pp. 633-6, 2004.
[78] M. S. Shypshyna, and N. S. Veselovsky, “Presynaptic Ca(2+)-permeable AMPA-receptors modulate paired-pulse depression in nociceptive sensory synapses,”
Neurosci Lett, vol. 585, pp. 1-5, 2015.
[79] P. E. Schulz, E. P. Cook, and D. Johnston, “Changes in paired-pulse facilitation suggest presynaptic involvement in long-term potentiation,” J Neurosci, vol. 14, no.
9, pp. 5325-37, 1994.
[80] 工藤卓, 田口隆久,“再構成生体神経回路網における知覚と知性の探求(<特集>脳と知覚),”
知能と情報 : 日本知能情報ファジィ学会誌, vol. 18, no. 3, pp. 402-413, 2006.
[81] P. E. Schulz, “Long-term potentiation involves increases in the probability of neurotransmitter release,” Proc Natl Acad Sci U S A, vol. 94, no. 11, pp. 5888-93, 1997.
[82] P. E. Schulz, and J. C. Fitzgibbons, “Differing mechanisms of expression for short-
参考文献
138
and long-term potentiation,” J Neurophysiol, vol. 78, no. 1, pp. 321-34, 1997.
[83] D. A. Wagenaar, J. Pine, and S. M. Potter, “An extremely rich repertoire of bursting patterns during the development of cortical cultures,” BMC Neurosci, vol. 7, pp. 11, 2006.
[84] M. A. Corner, “Reciprocity of structure-function relations in developing neural networks: the Odyssey of a self-organizing brain through research fads, fallacies and prospects,” Prog Brain Res, vol. 102, pp. 3-31, 1994.
[85] A. L. Barabasi, and R. Albert, “Emergence of scaling in random networks,” Science, vol. 286, no. 5439, pp. 509-12, 1999.
[86] X. Li, G. Ouyang, A. Usami, Y. Ikegaya, and A. Sik, “Scale-free topology of the CA3 hippocampal network: a novel method to analyze functional neuronal assemblies,”
Biophys J, vol. 98, no. 9, pp. 1733-41, 2010.
[87] P. Massobrio, V. Pasquale, and S. Martinoia, “Concurrent scale-free and small-world networks support criticality in cortical ensembles,” BMC Neuroscience, vol. 14, no.
Suppl 1, pp. P264-P264, 2013.
[88] L. W. Role, and G. D. Fischbach, “Changes in the number of chick ciliary ganglion neuron processes with time in cell culture,” J Cell Biol, vol. 104, no. 2, pp. 363-70, Feb, 1987.
[89] S. B. Kater, M. P. Mattson, and P. B. Guthrie, “Calcium-induced neuronal degeneration: a normal growth cone regulating signal gone awry (?),” Ann N Y Acad Sci, vol. 568, pp. 252-61, 1989.
[90] H. Akiyama, and H. Kamiguchi, “Second messenger networks for accurate growth cone guidance,” Dev Neurobiol, 2013.
[91] A. Kiyohara, T. Taguchi, and S. N. Kudoh, “Effects of electrical stimulation on autonomous electrical activity in a cultured rat hippocampal neuronal network,”
IEEJ Transactions on Electrical and Electronic Engineering, vol. 6, no. 2, pp.
163-167, 2011.
[92] D. M. Kullmann, “Silent synapses: what are they telling us about long-term potentiation?,” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 358, no. 1432, pp. 727-733, 2003.
[93] H. Toda, T. Suzuki, H. Sawahata, K. Majima, Y. Kamitani, and I. Hasegawa,
“Simultaneous recording of ECoG and intracortical neuronal activity using a flexible multichannel electrode-mesh in visual cortex,” Neuroimage, vol. 54, no. 1, pp. 203-12, 2011.
[94] D. Eytan, and S. Marom, “Dynamics and effective topology underlying synchronization in networks of cortical neurons,” J Neurosci, vol. 26, no. 33, pp.
参考文献
139 8465-76, 2006.
[95] K. Matsumoto, T. Ishikawa, N. Matsuki, and Y. Ikegaya, “Multineuronal spike sequences repeat with millisecond precision,” Front Neural Circuits, vol. 7, pp. 112, 2013.
[96] Y. Ikegaya, W. Matsumoto, H. Y. Chiou, R. Yuste, and G. Aaron, “Statistical significance of precisely repeated intracellular synaptic patterns,” PLoS One, vol. 3, no. 12, pp. e3983, 2008.
[97] J. Van Pelt, M. A. Corner, P. S. Wolters, W. L. Rutten, and G. J. Ramakers,
“Longterm stability and developmental changes in spontaneous network burst firing patterns in dissociated rat cerebral cortex cell cultures on multielectrode arrays,”
Neurosci Lett, vol. 361, no. 1-3, pp. 86-9, 2004.
[98] J. D. Rolston, D. A. Wagenaar, and S. M. Potter, “Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures,” Neuroscience, vol. 148, no. 1, pp. 294-303, 2007.
[99] A. Gal, and S. Marom, “Entrainment of the intrinsic dynamics of single isolated neurons by natural-like input,” J Neurosci, vol. 33, no. 18, pp. 7912-8, May 1, 2013.
[100] G. Shahaf, D. Eytan, A. Gal, E. Kermany, V. Lyakhov, C. Zrenner, and S. Marom,
“Order-based representation in random networks of cortical neurons,” PLoS Comput Biol, vol. 4, no. 11, pp. e1000228, 2008.
[101] L. Zullo, M. Chiappalone, S. Martinoia, and F. Benfenati, “A "spike-based" grammar underlies directional modification in network connectivity: effect on bursting activity and implications for bio-hybrids systems,” PLoS One, vol. 7, no. 11, pp. e49299, 2012.
[102] J. le Feber, J. Stegenga, and W. L. Rutten, “The effect of slow electrical stimuli to achieve learning in cultured networks of rat cortical neurons,” PLoS One, vol. 5, no.
1, pp. e8871, 2010.
[103] Z. C. Chao, D. J. Bakkum, and S. M. Potter, “Shaping embodied neural networks for adaptive goal-directed behavior,” PLoS Comput Biol, vol. 4, no. 3, pp. e1000042, 2008.
[104] H. Hayashi, and S. Ishizuka, “Chaotic nature of bursting discharges in the Onchidium pacemaker neuron,” Journal of Theoretical Biology, vol. 156, no. 3, pp.
269-291, 1992.
[105] 森敏生, 山崎秀樹, 甲斐昌一, “光刺激による脳波引き込みの空間特性,” 医用電子と生
体工学 : 日本ME学会雑誌, vol. 39, no. 4, pp. 284-291 , 2001.
[106] C. A. Thomas, Jr., P. A. Springer, G. E. Loeb, Y. Berwald-Netter, and L. M. Okun, “A miniature microelectrode array to monitor the bioelectric activity of cultured cells,”
Exp Cell Res, vol. 74, no. 1, pp. 61-6, 1972.
参考文献
140
[107] G. W. Gross, E. Rieske, G. W. Kreutzberg, and A. Meyer, “A new fixed-array multi-microelectrode system designed for long-term monitoring of extracellular single unit neuronal activity in vitro,” Neurosci Lett, vol. 6, no. 2-3, pp. 101-5, 1977.
[108] J. Pine, “Recording action potentials from cultured neurons with extracellular microcircuit electrodes,” J Neurosci Methods, vol. 2, pp. 19-31, 1980.
[109] G. W. Gross, B. K. Rhoades, H. M. Azzazy, and M. C. Wu, “The use of neuronal networks on multielectrode arrays as biosensors,” Biosens Bioelectron, vol. 10, no.
6-7, pp. 553-67, 1995.
[110] R. A. Bozym, F. Chimienti, L. J. Giblin, G. W. Gross, I. Korichneva, Y. Li, S. Libert, W.
Maret, M. Parviz, C. J. Frederickson, and R. B. Thompson, “Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro,” Exp Biol Med, vol.
235, no. 6, pp. 741-50, 2010.
[111] G. W. Gross, A. Harsch, B. K. Rhoades, and W. Gopel, “Odor, drug and toxin analysis with neuronal networks in vitro: extracellular array recording of network responses,”
Biosens Bioelectron, vol. 12, no. 5, pp. 373-93, 1997.
[112] C. Wu, K. Gopal, G. W. Gross, T. J. Lukas, and E. J. Moore, “An in vitro model for testing drugs to treat tinnitus,” Eur J Pharmacol, vol. 667, no. 1-3, pp. 188-94, 2011.
[113] M. Taketani, and M. Baudry, Advances in Network Electrophysiology: Using Multi-Electrode Arrays: Springer, 2006.
[114] G. W. Gross, and F. U. Schwalm, “A closed flow chamber for long-term multichannel recording and optical monitoring,” J Neurosci Methods, vol. 52, no. 1, pp. 73-85, 1994.
[115] L. J. Rosenberg, R. S. Jordan, G. W. Gross, D. G. Emery, and J. H. Lucas, “Effects of methylprednisolone on lesioned and uninjured mammalian spinal neurons: viability, ultrastructure, and network electrophysiology,” J Neurotrauma, vol. 13, no. 8, pp.
417-37, 1996.
[116] F. Esposti, M. G. Signorini, S. M. Potter, and S. Cerutti, “Statistical long-term correlations in dissociated cortical neuron recordings,” IEEE Trans Neural Syst Rehabil Eng, vol. 17, no. 4, pp. 364-9, 2009.
[117] N. J. MacLusky, T. Hajszan, and C. Leranth, “The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis,” Environ Health Perspect, vol. 113, no. 6, pp. 675-9, 2005.
[118] J. A. Brotons, M. F. Olea-Serrano, M. Villalobos, V. Pedraza, and N. Olea,
“Xenoestrogens released from lacquer coatings in food cans,” Environ Health Perspect, vol. 103, no. 6, pp. 608-12, 1995.
[119] N. K. Wilson, J. C. Chuang, M. K. Morgan, R. A. Lordo, and L. S. Sheldon, “An
参考文献
141
observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare,” Environ Res, vol. 103, no. 1, pp. 9-20, 2007.
[120] R. E. Chapin, J. Adams, K. Boekelheide, L. E. Gray, Jr., S. W. Hayward, P. S. Lees, B.
S. McIntyre, K. M. Portier, T. M. Schnorr, S. G. Selevan, J. G. Vandenbergh, and S. R.
Woskie, “NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A,” Birth Defects Res B Dev Reprod Toxicol, vol. 83, no. 3, pp.
157-395, 2008.
[121] L. N. Vandenberg, R. Hauser, M. Marcus, N. Olea, and W. V. Welshons, “Human exposure to bisphenol A (BPA),” Reprod Toxicol, vol. 24, no. 2, pp. 139-77, 2007.
[122] X. Ye, Z. Kuklenyik, L. L. Needham, and A. M. Calafat, “Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry,” J Chromatogr B Analyt Technol Biomed Life Sci, vol. 831, no.
1-2, pp. 110-5, 2006.
[123] J. C. Kim, H. C. Shin, S. W. Cha, W. S. Koh, M. K. Chung, and S. S. Han, “Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy,” Life Sci, vol. 69, no. 22, pp. 2611-25, 2001.
[124] R. W. Tyl, C. B. Myers, M. C. Marr, B. F. Thomas, A. R. Keimowitz, D. R. Brine, M. M.
Veselica, P. A. Fail, T. Y. Chang, J. C. Seely, R. L. Joiner, J. H. Butala, S. S. Dimond, S. Z. Cagen, R. N. Shiotsuka, G. D. Stropp, and J. M. Waechter, “Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats,”
Toxicol Sci, vol. 68, no. 1, pp. 121-46, 2002.
[125] M. Sakaue, S. Ohsako, R. Ishimura, S. Kurosawa, M. Kurohmaru, Y. Hayashi, Y.
Aokil, J. Yonemoto, and C. Tohyama, “Bisphenol-A Affects Spermatogenesis in the Adult Rat Even at a Low Dose,” Journal of occupational health, vol. 43, no. 4, pp.
185-190, 2001.
[126] Y. Toyama, F. Suzuki-Toyota, M. Maekawa, C. Ito, and K. Toshimori, “Adverse effects of bisphenol A to spermiogenesis in mice and rats,” Arch Histol Cytol, vol. 67, no. 4, pp. 373-81, 2004.
[127] A. M. Calafat, X. Ye, L. Y. Wong, J. A. Reidy, and L. L. Needham, “Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004,” Environ Health Perspect, vol. 116, no. 1, pp. 39-44, 2008.
[128] A. Matsushima, Y. Kakuta, T. Teramoto, T. Koshiba, X. Liu, H. Okada, T. Tokunaga, S. Kawabata, M. Kimura, and Y. Shimohigashi, “Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma,” J Biochem,