Acta Medica Okayama
Volume 37, Issue 5 1983 Article 3
O CTOBER 1983
Detection of DR antigen on leukemic cells from a patient suffering from adult T-cell leukemia and progressive systemic sclerosis.
Keiichi Mizushima
∗Yasumasa Takaya
†Taro Asano
‡Yoshitoshi Shinohara
∗∗Shin Motoi
††Shinya Suzuki
‡‡Zensuke Ota
§Keisuke Yano
¶∗Okayama University,
†Okayama University,
‡Okayama University,
∗∗Okayama University,
††Okayama University,
‡‡Okayama University,
§Okayama University,
¶Okayama University,
Copyright c1999 OKAYAMA UNIVERSITY MEDICAL SCHOOL. All rights reserved.
Detection of DR antigen on leukemic cells from a patient suffering from adult T-cell leukemia and progressive systemic sclerosis. ∗
Keiichi Mizushima, Yasumasa Takaya, Taro Asano, Yoshitoshi Shinohara, Shin Motoi, Shinya Suzuki, Zensuke Ota, and Keisuke Yano
Abstract
This report concerns an unusual case of adult T cell leukemia (ATL) complicated with progres- sive systemic sclerosis (PSS). The surface markers of peripheral blood mononuclear cells (PBM) and lymph node cells, both of which mainly consisted of leukemic cells, were examined. The effect of these cells on the pokeweed mitogen (PWM)-induced IgG synthesis by normal PBM also was studied. The leukemic cells formed rosettes with sheep red blood cells (SRBC; E) and ex- pressed T cell antigen, Leu-1, and DR antigen. The detection of cell surface antigens was carried out by employing monoclonal antibodies against these antigens. We diagnosed this case as DR positive ATL. In terms of the immunoregulatory function of these leukemic cells, the co-culture experiments showed that these cells had some suppressive effect on the PWM-induced IgG pro- duction by allogeneic normal PBM.
KEYWORDS:ATL, DR antigen(s), auto-immune disease
∗PMID: 6228126 [PubMed - indexed for MEDLINE]
Copyright (C) OKAYAMA UNIVERSITY MEDICAL SCHOOL
1 Mizushima et al.: Detection of DR antigen on leukemic cells from a patient
Produced by The Berkeley Electronic Press, 1983
2 Acta Medica Okayama, Vol. 37 [1983], Iss. 5, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss5/3
3 Mizushima et al.: Detection of DR antigen on leukemic cells from a patient
Produced by The Berkeley Electronic Press, 1983
4 Acta Medica Okayama, Vol. 37 [1983], Iss. 5, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss5/3
5 Mizushima et al.: Detection of DR antigen on leukemic cells from a patient
Produced by The Berkeley Electronic Press, 1983
6 Acta Medica Okayama, Vol. 37 [1983], Iss. 5, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss5/3
7 Mizushima et al.: Detection of DR antigen on leukemic cells from a patient
Produced by The Berkeley Electronic Press, 1983
