94_nenkai_endai

(1)

3-Y-F1-1

Oral administration of food-derived amino acid ergothioneine enhances learning and memory by phosphorylation of TrkB and promotion of neurogenesis in the hippocampal dentate gyrus

Yusuke Matsuo

¹

, Takahiro Ishimoto

¹

, Shunsuke Nakao

¹

, Yusuke Masuo

¹

, Satoshi Matsumoto

²

, Makoto Suzuki

²

, Yukio Kato

¹

1Fac. Pharm., Kanazawa Univ.,²L•S Corporation Co. Ltd.

YIA

(2)

The effects of Ninjinyoeto on spatial memory impairment in a rat model with cerebral ischemia and β-amyloid injection

Masaki Nagao

¹

, Akinobu Hatae

²

, Kazuma Mine

²

, Soichiro Tsutsumi

²

, Marika Hiarata

²

,

Kazuma Matsui

²

, Hiroya Omori

²

, Takuya Watanabe

^1,2

, Kaori Kubota

^1,2

, Shutaro Katsurabayashi

²

, Katsunori Iwasaki

^1,2

1Ins. Aging and Brain Sci., Fukuoka Univ., Fukuoka, Japan,²Dept. Neuropharmacol. Fac. Pharm. Sci. Fukuoka Univ. Fukuoka, Japan

(3)

3-Y-F1-3

The mice with exonic Reln deletion show cognitive dysfunction but not attention impairment in the touchscreen operant tasks

Geyao Dong

¹

, Taku Nagai

¹

, Jingzhu Liao

¹

, Daisuke Mori

²

, Bolati Wolar

¹

, Toshitaka Nabeshima

^3,4

, Norio Ozaki

²

, Kiyofumi Yamada

¹

1Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine,²Department of Psychiatry, Nagoya University Graduate School of Medicine,³Advanced Diagnostic System Research Laboratory Fujita Health University, Graduate School of Health Sciences,⁴Aino University

YIA

(4)

The role of voltage-dependent potassium channels in the medial prefrontal cortex in nicotine-induced enhancement of object recognition memory

Esaki Hirohito

¹

, Shoma Izumi

¹

, Akari Fukao

²

, Masaki Domoto

¹

, Tong Zhang

¹

, Naoya Nishitani

^1,2

, Satoshi Deyama

^1,2

, Katsuyuki Kaneda

^1,2

1Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ.,²Lab. Mol. Pharmacol., Sch.

Pharmaceut. Sci., Kanazawa Univ.

(5)

3-Y-F2-1

Anti-high mobility group box-1 (HMGB1) antibody therapy for spinal cord ischemia-reperfusion injury in rabbits

Muraoka Genya

¹

, Keyue Liu

²

, Handong Qiao

²

, Daiki Ousaka

²

, Dengli Wang

²

, Yasuhiro Fujii

¹

, Shingo Kasahara

¹

, Masahiro Nishibori

²

1Dept. Cardiovascular Surg., Okayama Univ.,²Dept. Pharmacol., Okayama Univ.

YIA

(6)

The identification of neuro-reparative lipids in ischemic stroke

Nakamura Akari

^1,2

, Seiichirou Skai

¹

, Makoto Murakami

³

, Takashi Shichita

^1,4

1Tokyo Metropolitan Inst.,²Tokyo Medical and Dental Univ.,³Tokyo Univ.,⁴Japan Agency for Medical Research and Development

(7)

3-Y-F2-3

TRPA1 plays a protective role in cognitive impairment and white matter injury in chronic cerebral hypoperfusion

Masashi Kakae, Hiroki Nakajima, Misa Morishima, Shota Tobori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ.

YIA

(8)

Imaging of water kinetics during cytotoxic edema using indirect MRI with O

¹⁷

-labeled water

Tomoe Ishikawa

¹

, Yutaka Hoshino

²

, Hiroyuki Kameda

²

, Yuji Komaki

⁴

, Miyuki Unekawa

³

, Yutaka Tomita

³

, Jin Nakahara

³

, Kohsuke Kudo

²

, Masato Yasui

¹

1Dept., Pharmacol., Sch., Med., Keio Univ.,²Dept., Radiol., Hokkaido Univ Hosp.,³Dept., Neurol., Sch., Med., Keio Univ.,⁴Central., Inst., Exp., Anim.

(9)

3-Y-F3-1

Development of Brain Molecular PET Imaging with a

¹⁸

F-labeled Small Protein Affinity Ligand

Takahiro Morito

¹

, Ryuichi Harada

^1,2

, Ren Iwata

³

, Yiqing Du

¹

, Nobuyuki Okamura

⁴

, Yukitsuka Kudo

²

, Kazuhiko Yanai

^1,3

1Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med.,²Dept. Gerontol. Geriatrics, Tohoku Univ.,³CYRIC, Tohoku Univ.,⁴Div. Pharmacol., Fac. Med., Tohoku Med. Pharmaceut. Univ.

YIA

(10)

Characterization of a novel monoamine oxidase-B tracer [ F]SMBT-1 for imaging of reactive astrocytes

Yiqing Du

¹

, Ryuichi Harada

^1,2

, Yu Akaida

³

, Takahiro Morito

¹

, Hiroyuki Arai

²

, Mari Yoshida

⁴

, Yukitsuka Kudo

²

, Shozo Furumoto

³

, Nobuyuki Okamura

⁵

, Kazuhiko Yanai

¹

1Dept. Pharmacol., Grad. Sch. Med., Tohoku Univ.,²Dept. Geriatrics and Gerontology, Div. Brain Science, Inst.

Development, Aging and Cancer, Tohoku Univ.,³Cyclotron and Radioisotope Ctr., Tohoku Univ.,⁴Inst.

Development, Aging and Cancer, Aichi Medical Univ.,⁵Div. Pharmacol., Fac. Med., Tohoku Medical and Pharmaceutical Univ.

(11)

3-Y-F3-3

A novel method of long-lasting single-particle tracking based on regenerative fluorescent labeling

Shinkuro Kobayashi, Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose

Dept. Pharm., Grad. Sch. Med., the Univ. of Tokyo

YIA

(12)

In vivo fluorescence imaging of extracellular ATP dynamics in brain ischemia

Nami Kitajima

¹

, Kenji Takikawa

¹

, Hiroshi Sekiya

²

, Daisuke Asanuma

¹

, Hirokazu Sakamoto

¹

, Shigeyuki Namiki

¹

, Masamitsu Iino

³

, Kenzo Hirose

¹

1Dept. of Pharmacol., Grad. Sch. of Med., Univ. of Tokyo,²Dept. of Physiol., Grad. Sch. of Med., Univ. of Tokyo,

3Dept. of Cell. and Mol. Pharmacol., Nihon Univ. Sch. of Med.

(13)

3-Y-G1-1

Voltage-dependence in I

CaL

block predicts EAD in drug-induced arrhythmias

Kimura Akira

¹

, Shingo Murakami

²

1Chuo Univ. Grad. Ele.,²Chuo Univ. Grad. Sci.& Eng.

YIA

(14)

Electrophysiological analysis of the anti-atrial fibrillatory action of oseltamivir using the paroxysmal atrial fibrillation canine model

Ryuichi Kambayashi

¹

, Yoshio Nunoi

¹

, Ai Goto

¹

, Yoshiki Hirokawa

¹

, Hiroko Izumi-Nakaseko

¹

, Mihoko Hagiwara-Nagasawa

¹

, Yoshinori Takei

²

, Akio Matsumoto

³

, Shinichi Kawai

⁴

,

Atsushi Sugiyama

^1,2,3,4

1Dept. Pharmacol., Faculty Med., Toho Univ.,²Dept. Translational Research & Cellular Therapeutics, Faculty Med., Toho Univ.,³Dept. Aging Pharmacol., Faculty Med., Toho Univ.,⁴Dept. Inflammation & Pain Control Research, Faculty Med., Toho Univ.

(15)

3-Y-G1-3

Effect of hyperglycemia on the cardiovascular functions in the isoflurane- anesthetized intact dogs

Hirokawa Yoshiki

¹

, Ryuichi Kambayashi

²

, Ai Goto

¹

, Yoshio Nunoi

²

, Hiroko Izumi-Nakaseko

^1,2

, Mihoko Hagiwara-Nagasawa

²

, Yoshinori Takei

³

, Akio Matsumoto

⁴

, Shinichi Kawai

⁵

, Jörg Täubel

⁶

, Atsushi Sugiyama

^1,2,3,4,5

1Dept. Pharmacol., Grad. Sch. Med., Toho Univ.,²Dept. Pharmacol., Faculty. Med., Toho Univ.,³Dept.

Translational Research & Cellular Therapeutics., Faculty. Med., Toho Univ.,⁴Dept. Aging Pharmacol., Faculty.

Med., Toho Univ.,⁵Dept. Inflammation & Pain Control Research, Faculty. Med., Toho Univ.,⁶Molecular & Clinical Sciences Research Institute, St George's University of London.

YIA

(16)

Biological sex differences in morphological function of embryonic murine coronary arteries

Shion Nagasawa

¹

, Masami Kodama

²

, Kazuho Sakamoto

¹

, Junko Kurokawa

¹

1Sch. Pharmaceut. Sci, University of Shizuoka,²IQB, The University of Tokyo

(17)

3-Y-G2-1

TRPC5 channel-Caveolin-1-eNOS signalplexes coordinate interplay between Ca

²⁺

and NO signals in endothelial cells

Reiko Sakaguchi

^1,2

, Nobuaki Takahashi

^1,3

, Takashi Yoshida

^1,4

, Nozomi Ogawa

¹

, Yoshifumi Ueda

¹

, Satoshi Hamano

¹

, Kaori Yamaguchi

¹

, Seishiro Sawamura

¹

, Shinichiro Yamamoto

^1,4

, Yuji Hara

¹

, Masayuki Mori

¹

, Tetsushi Furukawa

⁵

, Shunichi Shimizu

⁴

, Ryuji Inoue

⁶

, Yasuo Mori

^1,2

1Department of Engineering, Kyoto Univ,²iCeMS, Kyoto Univ,³Hakubi Project, Kyoto Univ,⁴Faculty of Pharmaceutical Sciences, Teikyo Heisei Univ,⁵Medical Research Institute, Tokyo Medical and Dental Univ,

6Department of Physiology, Fukuoka Univ.

YIA

(18)

Acute hypoxia enhances the proliferation of brain capillary endothelial cells via upregulation of Ca

²⁺

-activated Cl

^-

channel TMEM16A.

Takahisa Suzuki

¹

, Yoshiaki Suzuki

¹

, Kiyohumi Asai

²

, Yuji Imaizumi

¹

, Hisao Yamamura

¹

1Dept. Mol. and Cell. Pharmacol., Grad. Sch. Pharm., Nagoya City Univ.,²Dept. Mol. Neurobiol., Grad. Sch. Med., Nagoya City Univ.

(19)

3-Y-G2-3

CAMKII inhibitor as novel cardioprotective agent on doxorubicin cardiotoxicity

クルニアワンプリヨノアグン

, Junichiro Miake, Youkou Syuu, Katsunori Ichihara, Tatsuya Sawano, Keiko Nagata, Takeshi Imamura

Tottori University, Medical department, pharmacology

YIA

(20)

Development of high efficient method in human iPS induction from patient derived primary cells.

Tanaka Naomichi, Takaaki Senbonmatsu

Saitama medical university international medical center

(21)

3-Y-G3-1

Arginase 1 is involved in lacrimal hyposecretion in male NOD mice.

Yuta Ohno

¹

, Keitaro Satoh

^1,2

, Akiko Shitara

¹

, Haruna Nagase

¹

, Masanori Kashimata

¹

1Dept. Pharmacol., Asahi Univ. Sch. Dent.,²Dept. Pharmacol., Meikai Univ. Sch. Dent.

YIA

(22)

Evaluation of primate dental pulp regeneration by quantitative fluorescence imaging of macrophages

Yu Toida, Takanori Sato, Tadahiro Iimura

Dept Pharmacol, Hokkaido Univ Grad Sch Dent Med

(23)

3-Y-G3-3

Teriparatide improves bone quality through augmenting the linearity of bone collagen fibers, revealed by novel analysis of nonlinear optics imaging and AI-based morphometrical recognition method

Takanori Sato, Yu Toida, Tadahiro Iimura

Dept. Pharmocol. Grad. Sch. Dent Med., Hokkaido Univ.

YIA

(24)

Ca release-activated Ca channels are involved in osteoarthritic marker induction by interleukin-1β in mouse chondrocytes

Risa Kurose, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura

Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.