ラット中枢神経系の薬剤誘発性海綿状変化における2',3'-Cyclic Nucleotide 3'-Phosphodiesterase(CNPase)の経時的変化に関する研究
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(2) ࣛࢵࢺ୰ᯡ⚄⤒⣔ࡢ⸆ㄏⓎᛶᾏ⥥≧ኚ࠾ࡅࡿ ’’&\FOLF1XFOHRWLGH’3KRVSKRGLHVWHUDVH &13DVH
(3) ࡢ⤒ⓗኚ㛵ࡍࡿ◊✲ 㸰㸮㸰㸮ᖺ ᒱ㜧ᏛᏛ㝔㐃ྜ⋇་Ꮫ◊✲⛉ Ⳣ 㔝 ๛ .
(4) ࣛࢵࢺ୰ᯡ⚄⤒⣔ࡢ⸆ㄏⓎᛶᾏ⥥≧ኚ࠾ࡅࡿ ’’&\FOLF1XFOHRWLGH’3KRVSKRGLHVWHUDVH &13DVH
(5) ࡢ⤒ⓗኚ㛵ࡍࡿ◊✲ Ⳣ 㔝 ๛. .
(6) ࠙┠ḟࠚ ᗎㄽ ➨❶. ࣛࢵࢺ୰ᯡ⚄⤒⣔ࡢࢽࣜࣥㄏⓎᛶᾏ⥥≧ኚ࠾ࡅࡿ &13DVH ࡢ ⤒ⓗኚ㛵ࡍࡿ᳨ウ . ⥴ゝ ᮦᩱ࠾ࡼࡧ᪉ἲ ⤖ᯝ ⪃ᐹ ᑠᣓ ➨❶. ࣛࢵࢺ୰ᯡ⚄⤒⣔ࡢ࣊࢟ࢧࢡࣟࣟࣇ࢙ࣥཬࡧ࢝ࣉࣜࢰࣥㄏⓎᛶᾏ⥥≧ ኚ࠾ࡅࡿ &13DVH ࡢ⤒ⓗኚ㛵ࡍࡿ᳨ウ a≉⬻㸪ᑠ⬻㸪⬻ᖿࡘ࠸࡚ࡢ᳨ウa . ⥴ゝ ᮦᩱ࠾ࡼࡧ᪉ἲ ⤖ᯝ ⪃ᐹ ᑠᣓ ➨❶. ࣛࢵࢺ୰ᯡ⚄⤒⣔ࡢ࣊࢟ࢧࢡࣟࣟࣇ࢙ࣥཬࡧ࢝ࣉࣜࢰࣥㄏⓎᛶᾏ⥥≧ ኚ࠾ࡅࡿ &13DVH ࡢ⤒ⓗኚ㛵ࡍࡿ᳨ウ a⬨㧊ࡘ࠸࡚ࡢ᳨ウa . ⥴ゝ ᮦᩱ࠾ࡼࡧ᪉ἲ ⤖ᯝ ⪃ᐹ ᑠᣓ ⥲ᣓ ㅰ㎡ ཧ⪃ᩥ⊩ せ᪨ $EVWUDFW ᅗ .
(7) ᗎㄽ ࣛࢵࢺ୰ᯡ⚄⤒⣔ᾏ⥥≧ኚࢆㄏⓎࡍࡿ࠸ࡃࡘࡢྜ≀ࡀሗ࿌ࡉࢀ࡚࠸ ࡿ࠙㸪㸪㸪㸪㸪ࠚࠋᾏ⥥≧ኚࡣ㉸ᚤᙧែᏛⓗ㧊㠧ࡢゎ㞳࡛࠶ࡾ㸪 ࡉࡽᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷እⴥ࠺ࡋࡀ㏆᥋ࡋ࡚࡛ࡁࡓ࿘ᮇ㛫⥺ࡢゎ㞳ࡼ ࡿࡶࡢ࡛࠶ࡿࡇࡀศࡗ࡚࠸ࡿࠋ࠸ࡃࡘࡢྜ≀ࡼࡗ࡚ㄏⓎࡉࢀࡿᾏ⥥ ≧ኚࡢ⌮Ⓨ⏕࣓࢝ࢽࢬ࣒ࡣᵝࠎ࡛࠶ࡾ㸪ࢽࣜࣥࡣ㸪࣑ࢺࢥࣥࢻࣜࡢ㓟 ⓗࣜࣥ㓟ࢆ⬺ඹᙺࡋ㸪ᕼ✺㉳⭺⣽⬊ࡢᶵ⬟㞀ᐖࢆᘬࡁ㉳ࡇࡍࡇࡼࡗ࡚㸪 ࡲࡓ㸪࣊࢟ࢧࢡࣟࣟࣇ࢙ࣥ㸦+&3㸧ࡣ⬻ཬࡧ⬨㧊ࡢỈศ㔞ࢆቑຍࡉࡏࡿࡇ ࡼࡾ㸪ⓑ㉁ࡢᾏ⥥≧ኚࢆㄏⓎࡍࡿ࠙ 㸪㸪㸪ࠚࠋ୍᪉㸪࢝ࣉࣜࢰࣥ㸦&3=㸧 ࡣ㸪㓟ཬࡧ (5 ࢫࢺࣞࢫࡼࡾᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࢆᘬࡁ㉳ࡇࡋ㸪㧊 㠧ࡢᾏ⥥≧ኚࢆㄏⓎࡍࡿ࠙ࠚࠋᾏ⥥≧ኚࡢ㐍⾜కࡗ࡚㸪ᕼ✺㉳⭺⣽⬊ࡸ 㧊㠧㛵㐃ࡍࡿ⺮ⓑࡀࡢࡼ࠺࡞ືࡁࢆࡋ࡚࠸ࡿࡢ᳨ウࡍࡿࡓࡵ㸪ࢽࣜࣥ ᢞᐇ㦂࠾࠸࡚㸪࠸ࡃࡘࡢ㧊㠧㛵㐃㓝⣲ࡸ⺮ⓑࡘ࠸࡚චᰁⰍࢆᐇࡋ ࡓࠋࡑࡢ⤖ᯝ㸪㧊㠧ศᕸࡍࡿ㓝⣲࡛ᕼ✺㉳⭺⣽⬊ࡢศ࣐࣮࣮࢝ࡢ୍ࡘ࡛࠶ ࡿ &13DVH ኚࡀㄆࡵࡽࢀࡓࡓࡵ㸪&13DVH ╔┠ࡋࡓࠋ&13DVH ࡣ㸪ᮍ⇍ࡽ ᡂ⇍ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ୖࡸ㧊㠧ࡢ㍈⣴࿘ᅖ㡿ᇦศᕸࡋ࡚࠸ࡿ࠙ࠚࠋࡲࡓ㸪 &13DVH ࡣ㸪㧊㠧ᙧᡂ࠙ࠚࡸᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁ࡢఙ㛗࠙ࠚ㛵ࡋ࡚࠸ ࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡋࡋ࡞ࡀࡽ㸪㧊㠧ࡸᕼ✺㉳⭺⣽⬊ࡢയᐖ࡞㸪 ⚄⤒ẘᛶ࠾ࡅࡿ &13DVH ࡢᙺࡘ࠸࡚ࡢሗ࿌ࡣᑡ࡞࠸ࠋࡑࡇ࡛ᮏ◊✲࡛ࡣᾏ ⥥≧ኚㄏⓎࡢ &13DVH ࡢᙺࢆ⌮ゎࡍࡿࡓࡵ㸪㧊㠧ࡸᕼ✺㉳⭺⣽⬊യᐖࢆ ㄏⓎࡍࡿྜ≀ࢆࣛࢵࢺᢞࡋ㸪 &13DVH Ⓨ⌧ࡢ⤒ⓗኚࡘ࠸᳨࡚ウࡋࡓࠋ ึࡵࢽࣜࣥᢞࣛࢵࢺࡢ୰ᯡ⚄⤒⣔࠾ࡅࡿ &13DVH Ⓨ⌧ࡢ⤒ⓗኚ ࡘ࠸᳨࡚ウࡋࡓ㸦➨ ❶㸧ࠋḟ +&3 ཬࡧ &3= ᢞࣛࢵࢺࡢ୰ᯡ⚄⤒⣔࠾ࡅ .
(8) ࡿ &13DVH Ⓨ⌧ࡢ⤒ⓗኚࡘ࠸᳨࡚ウࡋࡓ㸦➨ ❶㸧ࠋࡉࡽኚࡢ⛬ᗘࡀ &13DVH ࡢⓎ⌧ᙳ㡪ࢆཬࡰࡍࡢࢆ᳨ウࡍࡿࡓࡵ㸪+&3 ཬࡧ &3= ᢞࣛࢵࢺ ࡢ⬨㧊࠾ࡅࡿ &13DVH Ⓨ⌧ࡢ⤒ⓗኚࡘ࠸࡚ࡶ᳨ウࡋࡓ㸦➨ ❶㸧 ࠋ. .
(9) ➨ ❶ ࣛࢵࢺ୰ᯡ⚄⤒⣔ࡢࢽࣜࣥㄏⓎᛶᾏ⥥≧ኚ࠾ࡅࡿ &13DVH ࡢ⤒ⓗኚ㛵ࡍࡿ᳨ウ .
(10) ⥴ゝ ࣛࢵࢺ୰ᯡ⚄⤒⣔ᾏ⥥≧ኚࢆㄏⓎࡍࡿ࠸ࡃࡘࡢྜ≀ࡀሗ࿌ࡉࢀ࡚࠸ ࡿ࠙㸪㸪㸪㸪㸪ࠚࠋࡑࡢ࠺ࡕࡢ୍ࡘ࡛࠶ࡿࢽࣜࣥࡣ㸪ᗈࡃ⏝ࡉࢀ ࡚࠸ࡿᕤᴗ⏝Ꮫ≀㉁࡛࠶ࡾ㸪ࢦ࣒ຍᕤ⏝Ꮫ⸆ရ㸪㓟㜵Ṇ㸪ᰁᩱ㸪 ┿⏝Ꮫ⸆ရ㸪་⸆ရ㸪㎰⸆࡞ࡢ᭷ᶵྜ≀ࡢྜᡂࡢ୰㛫యࡋ࡚⏝ࡉ ࢀ࡚࠸ࡿࠋࢽࣜࣥࢆ 㐌㱋ࡢᗂⱝࣛࢵࢺᢞࡍࡿࡇࡼࡗ࡚㸪⬨㧊ⓑ㉁ ᾏ⥥≧ኚࡀㄏⓎࡉࢀ㸪ᮏኚࡣ㸪㟁Ꮚ㢧ᚤ㙾Ꮫⓗ᳨⣴࠾࠸࡚㸪㧊㠧ࡢ࿘ ᮇ㛫⥺ࡢゎ㞳࡛࠶ࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ࠙㸪ࠚࠋ୍᪉㸪 㐌㱋௨ୖࡢࣛࢵ ࢺࢽࣜࣥࢆᢞࡋ࡚ࡶఱࡽ␗ᖖࡣㄏⓎࡉࢀ࡞࠸ࡇࡶሗ࿌ࡉࢀ࡚࠸ࡿ࠙㸪 ࠚࠋࡲࡓ㸪ࢽࣜࣥࡣ㸪࣑ࢺࢥࣥࢻࣜࡢ㓟ⓗࣜࣥ㓟ࢆ⬺ඹᙺࡋ࡚㸪ᕼ✺ ㉳⭺⣽⬊ࡢᶵ⬟㞀ᐖࢆᘬࡁ㉳ࡇࡍࡇࡼࡗ࡚ⓑ㉁ࡢᾏ⥥≧ኚࢆㄏⓎࡍࡿࡇ ࡀ▱ࡽࢀ࡚࠸ࡿ࠙ 㸪㸪ࠚ ࠋ㧊㠧㛵㐃㓝⣲ࡸᵓᡂ⺮ⓑࡋ࡚࣑࢚ࣜࣥሷᇶ ᛶ⺮ⓑ㸦0%3㸧㸪ࣉࣟࢸ࢜ࣜࣆࢻ⺮ⓑ㸦3/3㸧㸪࢞ࣛࢡࢺࢭࣞࣈࣟࢩࢻ㸦*DO㸧ࡸ &13DVH ࡀ࠶ࡾ㸪 0%3 ཬࡧ 3/3 ࡣ㧊㠧ࡢࡓࡿᵓᡂ⺮ⓑ࡛๓⪅ࡣ㧊㠧ࡢᐦ⥺㸪 ᚋ⪅ࡣ㧊㠧ࡢ࿘ᮇ㛫⥺ศᕸࡋ࡚࠸ࡿ࠙ ࠚ 㸬*DO ࡣ㧊㠧⬡㉁ྵ᭷㔞ࡢ ࢆ༨ࡵ ࡚࠾ࡾ࠙ࠚ 㸪&13DVH ࡣ㧊㠧ࡢ㍈⣴࿘ᅖ㡿ᇦᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷㡿ᇦศᕸ ࡋ࡚࠸ࡿ࠙ࠚ ࠋࢽࣜࣥࢆᢞࡋࡓⱝ㱋ࣛࢵࢺࡢ୰ᯡ⚄⤒⣔࠾࠸࡚㸪ᾏ⥥≧ ኚㄏⓎࡢ㧊㠧㛵㐃㓝⣲ࡸ⺮ⓑ㸪ࡍ࡞ࢃࡕ㸪&13DVH㸪࣑࢚ࣜࣥሷᇶᛶ⺮ⓑ 㸦0%3㸧㸪ࣉࣟࢸ࢜ࣜࣆࢻ⺮ⓑ㸦3/3㸧ཬࡧ࢞ࣛࢡࢺࢭࣞࣈࢩࢻ㸦*DO㸧ࡀࡢࡼ ࠺࡞ᣲືࢆ♧ࡍࡢࢆ⌮⤌⧊Ꮫⓗㄪࡓࡇࢁ㸪&13DVH ࡢࡳኚࡀㄆࡵ ࡽࢀࡓࠋ&13DVH ࡣ㸪㍈⣴࿘ᅖ㡿ᇦᮍ⇍ࡽᡂ⇍ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ୖᏑ ᅾࡍࡿศ࣐࣮࣮࢝ࡢ୍ࡘ࡛࠶ࡿ࠙ࠚࠋࡲࡓ㸪&13DVH ࡣ㸪㧊㠧ᙧᡂ࠙ࠚࡸ ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁ࡢఙ㛗࠙ࠚ㛵ࡋ࡚࠸ࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡋ. .
(11) ࡋ㸪㧊㠧ࡸᕼ✺㉳⭺⣽⬊ࡢയᐖ࡞㸪⚄⤒ẘᛶ࠾ࡅࡿ &13DVH ࡢᙺࡘ ࠸࡚ࡢሗ࿌ࡣᑡ࡞࠸ࠋࡑࡇ࡛ᮏ❶࡛ࡣ㸪ࢽࣜࣥᢞࡼࡿᾏ⥥≧ኚཬࡧᢠ &13DVH ᢠయࢆ⏝࠸ࡓචᰁⰍࡼࡿ &13DVH Ⓨ⌧ࡢ⤒ⓗኚࡘ࠸࡚ሗ࿌ࡍ ࡿࠋ. .
(12) ᮦᩱ᪉ἲ ື≀ 㐌㱋ࡢ &UOM㸸&'㸦6'㸧ࣛࢵࢺ㸦᪥ᮏࢳ࣮ࣕࣝࢫࣜࣂ࣮㸧㸪㞝 ༉ࢆ⏝࠸ࡓࠋ ᚤ⏕≀ࣞ࣋ࣝࡣ 6SHFLILF3DWKRJHQ)UHH㸦63)㸧࡛࠶ࡗࡓࠋࣛࢵࢺࡣ㸪 ᗘ Υ㸪 ‵ᗘ 㸣㸪Ẽ ᅇ㸭㛫㸪↷᫂㛫 㛫㸭᪥⥔ᣢࡉࢀࡓື≀ᐊ ࠾࠸࡚㸪࣏࣮ࣜ࢝࣎ࢿ࣮ࢺࢣ࣮ࢪ࡚㣫⫱ࡋ㸪 ȝP ࣇࣝࢱ࣮ℐ㐣ᚋ⣸እ⥺ ↷ᑕࡋࡓỈ㐨Ỉᨺᑕ⥺⁛⳦῭ࡳࡢᐇ㦂ື≀⏝ᅛᙧ㣫ᩱ 0)㸦࢚࢜ࣜࣥࢱࣝ㓝 ẕ㸧ࢆ⮬⏤ᦤྲྀࡉࡏࡓࠋ ྜ≀ ࢽࣜࣥ㸦&+1+ࠊ⣧ᗘ 㸣㸪ࣟࢵࢺ␒ྕ %+㸪&$6 ␒ྕ 㸧 ࡣࠊ6LJPD$OGULFK ♫㸦ᮾிࠊ᪥ᮏ㸧ࡽධᡭࡋࡓࠋ࣮࢜ࣜࣈἜࡣࠊ⁐፹ࡋ࡚ ࢚࢜ࣜࣥࢱࣝ〇⸆ᰴᘧ♫㸦ᒣᙧ㸪᪥ᮏ㸧ࡽ㉎ධࡋࡓࠋ ᐇ㦂ࣉࣟࢺࢥ࣮ࣝ ࣛࢵࢺࢆయ㔜࡛ᒙูࡋ㸪ࢽࣜࣥ㠀ᢞ⩌㸦ᑐ↷⩌㸧ᢞ⩌ศࡅ㸪ࡉ ࡽᏳᴦṚ᪥ࢆࣛࣥࢲ࣒ࡾᙜ࡚ࡓࠋື≀ࡣ㸪ᙉไ⤒ཱྀࡼࡾ PJNJ ࡢࢽࣜࣥࡲࡓࡣ࣮࢜ࣜࣈἜࡢ࠸ࡎࢀࢆ ᅇᢞࡋࡓࠋ⏝㔞ࡣ㸪௨๓ࡢሗ࿌ ࡢ⤖ᯝᇶ࡙࠸࡚Ỵᐃࡋࡓ࠙㸪ࠚࠋᐇ㦂ࢹࢨࣥࢆ 7DEOH ♧ࡍࠋ࣌ࣥࢺ ࣂࣝࣅࢱ࣮ࣝࢼࢺ࣒ࣜ࢘㸦ࢿࣥࣈࢱ࣮ࣝὀᑕ㸪᪥ᮏఫ〇⸆ᰴᘧ♫㸧ࡢ⭡ ⭍ෆὀᑕࡼࡿ㯞㓉ୗ࠾࠸࡚㸪ᕥᚰᐊࡽ 㸣ࣃ࣒ࣛ࣍ࣝࣝࢹࣄࢻỈ⁐ᾮࢆ ℺ὶࡋ㸪ྑᚰᡣࡽࡢᨺ⾑ࡼࡾᢞᚋ 㸪㸪㸪㸪㸪 ཬࡧ ᪥┠Ᏻᴦ Ṛࡉࡏࡓࠋ࡞࠾㸪ᢞ᪥ࢆ ᪥┠ࡋࡓࠋ .
(13) ⤌⧊Ꮫⓗ᳨ᰝ ࡍ࡚ࡢࣛࢵࢺࡽ⬻㸪⬨㧊㸪୕ཫ⚄⤒㸪ཬࡧᆘ㦵⚄⤒ࢆ᥇ྲྀࡋ㸪㸣୰ᛶ ⦆⾪࣐࡛࣍ࣝࣜࣥᅛᐃࡋࡓࠋᅛᐃࡋࡓ⤌⧊ࡣ㸪ᐃἲᚑࡗ࡚㸪ྛ⮚ჾࡢᶓ᩿㠃 ࡘ࠸࡚㸪ࣃࣛࣇࣥໟᇙࡋ࡚ษ∦ࢆస〇ࡋࡓࠋษ∦ࡣ +(ᰁⰍࢆࡋ࡚⤌⧊ Ꮫⓗほᐹࡋࡓࠋࡲࡓ㸪⬨㧊㸦⬚㒊㸧ࡘ࠸࡚㸪චᰁⰍࢆᐇࡋࡓࠋ୍ḟᢠ యࡋ࡚㸪ࣄࢺ &13DVH㸦 &KHPLFRQ,QWHUQDWLRQDO,QF7HPHFXOD&$86$㸧㸪 ࣄࢺ 0%3㸦 6HURWHF/WG2[IRUG(QJODQG㸧㸪3/3㸦 &KHPLFRQ,QWHUQDWLRQDO ,QF 7HPHFXOD &$ 86$㸧ཬࡧ࢘ࢩ *DO㸦 &KHPLFRQ ,QWHUQDWLRQDO ,QF 7HPHFXOD&$86$㸧ࢆ⏝ࡋࡓࠋᢠཎ㈿ά㛵ࡋ࡚ࡣ㸪ࢫࣛࢻࢆ 㸣࣒ ࣀࢭ࣮ࣂ࣮㸦᪥Ύ (0 ♫㸪ᮾி㸪᪥ᮏ㸧⛣ࡋ㸪:0: ࣉࣟࢭࢵࢧ࣮㸦0,㸪 ᮾᒇ㸪ᮾி㸪᪥ᮏ㸧࡛ Υࠊ ศ㛫ࠊ࣐ࢡ࢙࣮ࣟ࢘ࣈฎ⌮ࢆࡋࡓࠋᢠయࡢ౪ ⤥※⏝ᕼ㔘⋡ࢆ 7DEOH ♧ࡍࠋ ᾏ⥥≧ኚཬࡧ &13DVH චᰁⰍࡢ⛬ᗘࢆ ࡘࡢࢢ࣮ࣞࢻศ㢮ࡋ㸪⣔ิ࡛ ホ౯ࡋࡓࠋᾏ⥥≧ኚཬࡧ &13DVH චᰁⰍࡣ㸪௨ୗࡢࡼ࠺ࢢ࣮ࣞࢹࣥࢢࡋ ࡓࠋᾏ⥥≧ኚࡢሙྜ㸪ࢫࢥ 㸸ኚࡀ࡞ࡋ㸦㸧㸪ࢫࢥ 㸸㍍ᗘࡢᾏ⥥≧ኚ 㸦㸧㸪ࢫࢥ 㸸୰➼ᗘࡢᾏ⥥≧ኚ㸦㸧㸪ࢫࢥ 㸸㔜ᗘࡢᾏ⥥≧ኚ㸦㸧ࠋ &13DVH චᰁⰍࡢሙྜ㸪ࢫࢥ 㸸ᑠᆺࡢᕼ✺㉳⭺⣽⬊࡛⣽⬊㉁ቃ⏺ἢࡗ࡚ ࢃࡎ㝧ᛶᛂࡀほᐹࡉࢀࡿ㸦㸧 㸪ࢫࢥ 㸸㍍ᗘࡽ୰➼ᗘࡢ㝧ᛶᛂࡀ㸪 ᕼ✺㉳⭺⣽⬊ࡢ㍍ᗘ⭘ࡋࡓ⣽⬊㉁య࡛ほᐹࡉࢀࡿ㸦㸧㸪ࢫࢥ 㸸୰➼ ᗘࡢ㝧ᛶᛂࡀ㸪ᕼ✺㉳⭺⣽⬊ࡢ㍍ᗘ⭘ࡋࡓ⣽⬊㉁య࡛ほᐹࡉࢀࡿ㸦㸧 㸪 ࢫࢥ 㸸㔜ᗘࡢ㝧ᛶᛂࡀ㸪ᕼ✺㉳⭺⣽⬊ࡢ⭘ࡋࡓ⣽⬊㉁య࡛ほᐹࡉࢀࡿ 㸦㸧ࠋ࠸ࡎࢀࡢホ౯ࡶࢫࢥࡢᖹᆒ್ࢆ⟬ฟࡋࡓࠋ ᢠ࢘ࢩࢢࣜ⥺⥔ᛶ㓟ᛶࢱࣥࣃࢡ㉁ᢠయ㸦*)$3㸪㸸㸪'$.2-DSDQ/WG㸪 7RN\R㸪-DSDQ㸧ཬࡧᢠࣄࢺ &13DVH ᢠయ㸦㸸㸪&KHPLFRQ ,QWHUQDWLRQDO㸪,QF㸪 .
(14) 7HPFXOD㸪&$㸪86$㸧ࢆ⏝ࡋ࡚㸪㔜ච⺯ගᶆ㆑ࢆ⾜࡞ࡗࡓࠋᢠ *)$3 ᢠయ ࡣ࣮ࣟࢲ࣑ࣥ㸪ᢠ &13DVH ᢠయࡣ $OH[D)OXRU ࢆ⏝࠸࡚ᰁⰍࡋࡓࠋᶆᮏࢆ⺯ග 㢧ᚤ㙾㸦%;㸪࢜ࣜࣥࣃࢫᰴᘧ♫㸪ᮾி㸪᪥ᮏ㸧᳨࡛ᰝࡋࡓࠋ 㟁Ꮚ㢧ᚤ㙾Ꮫⓗ᳨ᰝ ⬨㧊㸦⬚㒊㸧ࡢ⤌⧊∦ࢆ 㸣ࣃ࣒ࣛ࣍ࣝࣝࢹࣄࢻỈ⁐ᾮ࡛⣙ 㛫ᅛᐃࡋ㸪 㸣ᅄ㓟࢜ࢫ࣑࣒࡛࢘ 㛫ᚋᅛᐃࡋࡓࠋ⅊ⓑ㉁ⓑ㉁ࡢ୧᪉ࢆ࢚࣏࢟ࢩᶞ⬡ ໟᇙࡋ㸪ཌษࡾษ∦స〇ᚋ㸪ࢺࣝࢪࣥࣈ࣮࡛ࣝᰁⰍࡋࡓࠋ㉸ⷧษ∦ࢆస〇ࡋ㸪 㓑㓟࢘ࣛࢽࣝཬࡧࢡ࢚ࣥ㓟㖄ࡼࡿ㔜ᰁⰍࢆࡋࡓᚋ㸪㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾 㸦+㸪᪥❧㸪ᮾி㸪᪥ᮏ㸧࡛ほᐹࡋࡓࠋ ࡇࡢᐇ㦂ࡣࠕື≀ᐇ㦂㛵ࡍࡿᣦ㔪㸦ᰴᘧ♫㹊㹑㹇࣓ࢹ࢚ࣥࢫ ⸆ᨭ ᴗᮏ㒊 ヨ㦂◊✲ࢭࣥࢱ࣮㸧 ࠖᇶ࡙ࡁ㸪㮵ᓥ◊✲ᡤື≀ᐇ㦂ጤဨࡢᢎㄆ ࢆᚓ࡚ᐇࡋࡓࠋ. .
(15) ⤖ᯝ ⤌⧊Ꮫⓗ᳨ᰝ ࢽࣜࣥᢞࣛࢵࢺ࡛ࡣ㸪ᶫ㸪ᘏ㧊ཬࡧ⬨㧊࠾࠸࡚㸪ᾏ⥥≧ኚࡀ ᪥┠ ࡽ ᪥┠ࡅ࡚ㄆࡵࡽࢀࡓࠋ≉⬨㧊ࡢኚࡣ㢧ⴭ࡛࠶ࡾ㸪⬚㒊⬨㧊ⓑ㉁ ࡢእഃཬࡧ⭡ഃ⣴࡛᭱ࡶ㔜ᗘ࡛࠶ࡗࡓ㸦ᅗ 㸧ࠋࡲࡓ㸪ᾏ⥥≧ኚࡣ ᪥┠ࡽ ᪥┠ࡅ࡚ኚࡢ⛬ᗘࡣࣆ࣮ࢡ㐩ࡋࡓࠋ୕ཫ⚄⤒ཬࡧᆘ㦵⚄⤒࡛ࡣ⚄⤒ ⥺⥔ࡢኚᛶࡀㄆࡵࡽࢀࡓࠋࡑࡢࡢ⬻ࡢ㒊࠾࠸࡚ⴭኚࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ &13DVH චᰁⰍ࡛ࡣ㸪⤒ⓗ࡞ኚࡀㄆࡵࡽࢀࡓࠋ୍᪉㸪0%3㸪3/3 ཬࡧ *DO චᰁⰍ࡛ኚࡣほᐹࡉࢀ࡞ࡗࡓࠋࢽࣜࣥᢞࣛࢵࢺ࡛ࡣ㸪 ᪥┠ &13DVH ࡢ㍍ᗘࡽ୰➼ᗘࡢ㝧ᛶᛂࡀᕼ✺㉳⭺⣽⬊ࡢ⭘ࡋࡓ⣽⬊㉁࡛ㄆࡵࡽࢀࡓࠋ ᪥┠ࡽ ᪥┠࡛ࡣᕼ✺㉳⭺⣽⬊ࡢ⭘ࡣ᫂ࡽ࡛࠶ࡾ㸪&13DVH ࡢ㔜ᗘ࡞㝧ᛶ ᛂࡀᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁యㄆࡵࡽࢀࡓ㸦ᅗ % ཬࡧ &㸧ࠋᑐ↷⩌ẚ㍑ ࡋ࡚㸪 ᪥┠ࡢᕼ✺㉳⭺⣽⬊࡛ࡣ㸪㝧ᛶᛂࡸ⣽⬊㉁ࡢ⭘ࡣㄆࡵࡽࢀ࡞ࡗ ࡓ㸦ᅗ $㸧 ࠋࡍ࡞ࢃࡕ㸪&13DVH ࡢⓎ⌧ࡣ ᪥┠ ᪥┠ࣆ࣮ࢡ㐩ࡋ㸪ࡑࡢ ᚋࡍࡄῶᑡࡋࡓ㸦ᅗ 㸧 ࠋ㔜ච⺯ගᰁⰍ࡛ࡣ㸪⥳Ⰽ⺯ග㸦ᅗ $㸧࡛♧ࡉࢀ ࡿ &13DVH 㝧ᛶᕼ✺㉳⭺⣽⬊ࡣ㸪㉥Ⰽ⺯ග㸦ᅗ %㸧࡛♧ࡉࢀࡿ *)$3 㝧ᛶᫍ≧ ⭺⣽⬊ẚ㍑ࡋ࡚㢧ⴭ⭘ࡋ࡚࠸ࡓࠋ⥳Ⰽ⺯ග㉥Ⰽ⺯ගࡢ୧᪉ࡀ㔜࡞ࡿ㡿 ᇦࡣㄆࡵࡽࢀ࡞ࡗࡓ㸦ᅗ &㸧ࠋ 㟁Ꮚ㢧ᚤ㙾Ꮫⓗ᳨ᰝ 㧊㠧ࡢゎ㞳ࡀ ᪥┠ཬࡧ ᪥┠ㄆࡵࡽࢀ㸦ᅗ $ ཬࡧ %㸧㸪 ᪥┠࡛ࡣቑຍ ࡋ࡚࠸ࡓࠋࡲࡓ㸪ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁ࡀ㧊㠧ධࡋ࡚࠸ࡿീࡶㄆࡵࡽࢀࡓࠋ ࡉࡽ㸪ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁ᑡ㔞ࡢ⭷≧จ㞟య㸦0$ PHPEUDQRXVDJJUHJDWHV㸧. .
(16) ࡀㄆࡵࡽࢀࡓ㸦ᅗ & ཬࡧ '㸧 ࠋ0$ ࡣ⥥≧ࡢෆᐜ≀ࡲࡓࡣ㧊㠧ᵓ㐀≀ࡀྵࡲ ࢀ࡚࠸ࡓࠋᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁࡛ࡣ㸪ᑐ↷⩌㸦ᅗ $㸧ẚ㍑ࡋ࡚㸪㐟㞳ࣜ࣎ ࢯ࣮࣒⢒㠃ᑠ⬊యࡢቑຍࡀ ᪥┠ཬࡧ ᪥┠ㄆࡵࡽࢀࡓ㸦ᅗ %㸧ࠋࡲࡓ㸪 ࣑ࢺࢥࣥࢻࣜࡢ⭘⬽ࡶㄆࡵࡽࢀࡓࠋ㧊㠧ゎ㞳ࡢ⛬ᗘࡣ㸪 ᪥┠ࡽ ᪥┠ ࡅ࡚㢧ⴭቑຍࡋ㸪0$ ࡶ㧊㠧ゎ㞳ࡢ⛬ᗘᑐᛂࡍࡿࡼ࠺ቑຍࡋ࡚࠸ࡓࠋ. .
(17) ⪃ᐹ ࢽࣜࣥᢞࡼࡗ࡚⬨㧊ⓑ㉁ࡢᾏ⥥≧ኚࡀㄆࡵࡽࢀ㸪㉸ᚤᙧែᏛⓗࡣ 㧊㠧ࡢゎ㞳ࡋ࡚ほᐹࡉࢀ㸪ࡉࡽ㟁Ꮚ㢧ᚤ㙾Ꮫⓗ᳨ᰝ࡛ࡣ 0$ ࡀᕼ✺㉳⭺⣽ ⬊ࡢ⣽⬊㉁ほᐹࡉࢀࡓࠋ0$ ࡢᛶ≧ࡘ࠸࡚ࡢヲ⣽ࡣ᫂ࡔࡀ㸪⬡㉁ᡂศࡢ␗ ᖖ࡞⏝ࡢሙྜ 0$ ࡀほᐹࡉࢀࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ࠙㸪ࠚࠋࡉࡽ୰ ᯡ⚄⤒⣔ࡢ㧊㠧ᙧᡂࡀᦆ࡞ࢃࢀࡓ EODFNWUHPRUKDPVWHU࠙ࠚཬࡧᡓ࣐࢘ࢫ࠙ࠚ ࡢᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁࡛ࡶほᐹࡉࢀࡿࡇࡀ▱ࡽࢀ࡚࠸ࡿࡇࡽ㸪0$ ࡣ␗ ᖖ࡞㧊㠧ᙧᡂ㉳ᅉࡍࡿࡶࡢ⪃࠼ࡿࠋ &13DVH ࡢⓎ⌧ࡣ⬨㧊ⓑ㉁ࡢᾏ⥥≧ኚࡀㄆࡵࡽࢀࡿ๓ࡽቑຍࡋ㸪ࣆ࣮ࢡ 㐩ࡋࡓࠋ㟁Ꮚ㢧ᚤ㙾Ꮫⓗ᳨ᰝ࡛ࡣ㸪ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁ෆ㐟㞳ࣜ࣎ࢯ࣮࣒ ⢒㠃ᑠ⬊యࡢቑຍࡀᾏ⥥≧ኚࡢฟ⌧๓ㄆࡵࡽࢀ㸪⺮ⓑ㉁ྜᡂࡢቑᙉࡀ♧၀ ࡉࢀࡓࠋᾏ⥥≧ኚࡀㄆࡵࡽࢀࡓ ᪥┠௨㝆㸪&13DVH ࡢⓎ⌧ࡣⴭࡋࡃῶᑡࡋࡓࠋ ࢽ࣡ࢺࣜࡢ୰ᯡ⚄⤒⣔ኚᛶኚࢆㄏⓎࡍࡿ᭷ᶵࣜࣥྜ≀࠾࠸࡚㸪&13DVH ࡢⓎ⌧ࡣࢺࣜRࢡࣞࢩࣝࣜࣥ㓟㸪ࢪࢯࣉࣟࣆࣝࣇࣝ࢜ࣟࣜࣥ㓟ཬࡧࣞࣉࢺࣇ ࢛ࢫࡢᢞࡼࡗ࡚ῶᑡ࠙ࠚࡋ㸪6㸪6㸪6ࢺࣜQࣈࢳࣝ࣍ࢫ࣍ࣟࢺࣜࢳ࢚࢜ ࣮ࢺᢞࡼࡗ࡚ቑຍ࠙㸪ࠚࡋࡓࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡲࡓ㸪ࣛࢵࢺ⬨㧊 ᦆയࣔࢹࣝ࠾࠸࡚㸪&13DVH ࡢ P51$ ཬࡧ⺮ⓑ㉁ࡣᦆയᚋᛴ㏿ቑຍࡋ㸪ᦆയ ᚋ ศ࡛ࣆ࣮ࢡ㐩ࡋ㸪 㐌㛫ࢆࡅ࡚ᚎࠎࢥࣥࢺ࣮ࣟࣝࣞ࣋ࣝࡲ࡛ῶᑡࡍ ࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ࠙ࠚࠋᅇ㸪&13DVH ࡢචᰁⰍཬࡧ㟁Ꮚ㢧ᚤ㙾Ꮫⓗ ᳨ᰝࡢ⤖ᯝࡽ㸪ࢽࣜࣥᢞ┤ᚋࡽᾏ⥥≧ኚࡢ㛤ጞࡲ࡛ࡢ㛫ᕼ✺㉳⭺ ⣽⬊࡛ࡣ &13DVH ࡢྜᡂಁ㐍ࡀ㉳ࡁ࡚࠸ࡿྍ⬟ᛶࡀ♧ࡉࢀࡓࠋࡲࡓ㸪ᕼ✺㉳⭺⣽ ⬊ࡢ⣽⬊άᛶࡣࢽࣜࣥࡢẘᛶࡼࡿ㧊㠧ࡢയᐖࡼࡗ࡚ຍ㏿ࡉࢀ㸪&13DVH Ⓨ⌧ࡢ⤒ⓗ࡞ኚࢆ⏕ࡌࡉࡏࡓࡶࡢ⪃࠼ࡿࠋ&13DVH ௨እࡢ㧊㠧㛵㐃⺮ⓑ࡛. .
(18) ࠶ࡿ 0%3㸪3/3㸪*DO ኚࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ&13DVH ࡣ㧊㠧㍈⣴ࡢ 㛫ศᕸࡋ࡚࠸ࡿࡀ㸪0%3 3/3 ࡣ㧊㠧ศᕸࡋ࡚࠸ࡿ࠙ࠚࠋࡇࡢศᕸࣃࢱ࣮ ࣥࡢ㐪࠸ࡀ㸪ࢽࣜࣥᢞᚋࡢ㓝⣲㸪⺮ⓑ㉁㸪ࡲࡓࡣ⬡㉁Ⓨ⌧ࡢ㐪࠸㉳ᅉࡋ ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋࡑࡢ⤖ᯝ㸪ࢽࣜࣥࡀ &13DVH ࢆྵࡴ㡿ᇦ≉␗ⓗ ᙳ㡪ࡋ㸪᭱⤊ⓗ &13DVH ࡢ⏕⏘ࡀቑຍࡋࡓࡇࡀ♧၀ࡉࢀࡓࠋࡉࡽ㸪*DO ࡣ⏕ᚋ ᪥ࡽ ᪥ࡢࣛࢵࢺ࡛ᛴ㏿ቑຍࡍࡿሗ࿌ࡉࢀ࡚࠸ࡿ࠙ࠚ ࠋ*DO ࡣ ṇᖖࡢ⬨㧊࡛ࡶࢇᰁⰍࡉࢀ࡞ࡗࡓࡓࡵ㸪 㐌㱋ࡲࡓࡣ 㐌㱋ࡢࣛࢵࢺ࡛ ࡣࢇⓎ⌧ࡋ࡚࠸࡞࠸ྍ⬟ᛶࡀ࠶ࡿࠋ 㧊㠧ࡢゎ㞳ཬࡧ 0$ ࡣ㸪ࢽࣜࣥ༢ᅇᢞᚋ㸪᳨⣴࣏ࣥࢺࡋ࡚ࡣ᭱ࡶ᪩ ࠸Ⅼ࡛࠶ࡿ ᪥┠ࡽㄆࡵࡽࢀࡓࠋ&13DVH Ⓨ⌧ࡣᾏ⥥≧ኚࡀㄆࡵࡽࢀࡿ๓ ࣆ࣮ࢡ㐩ࡋࡓࡀ㸪ᾏ⥥≧ኚࡢฟ⌧௨㝆ࡽⴭࡋࡃῶᑡࡋࡓࠋ&13DVH Ⓨ⌧ ࡀᕼ✺㉳⭺⣽⬊ᑐࡍࡿࢽࣜࣥࡢ┤᥋ⓗࡲࡓࡣ㛫᥋ⓗస⏝㉳ᅉࡍࡿ࠺ ࡣ᫂ࡽ࡛ࡣ࡞࠸ࡀ㸪0%3㸪3/3㸪ࡲࡓࡣ *DO ኚࡀㄆࡵࡽࢀ࡞࠸ࡶ㛵ࢃ ࡽࡎ㸪&13DVH ࡛⤒ⓗኚࡀㄆࡵࡽࢀࡓࡇࡽ㸪&13DVH ᾏ⥥≧ኚࡢ 㛫ᐦ᥋࡞㛵ಀࡀ࠶ࡿࡇࡀ♧၀ࡉࢀࡓࠋ. .
(19) ᑠᣓ ࢽࣜࣥࢆᗂⱝࣛࢵࢺ༢ᅇᢞࡍࡿࡇࡼࡗ࡚㸪⬨㧊ⓑ㉁ࡢᾏ⥥≧ኚ ࡀㄆࡵࡽࢀ㸪ᾏ⥥≧ኚࡀㄆࡵࡽࢀࡿ๓ &13DVH Ⓨ⌧ࡀࣆ࣮ࢡ㐩ࡋ࡚࠸ࡿࡇ ࡀุ᫂ࡋࡓࠋⓎ⌧ࡀࣆ࣮ࢡ㐩ࡍࡿ๓ࡢᕼ✺㉳⭺⣽⬊ࡢ㟁Ꮚ㢧ᚤ㙾Ꮫⓗ᳨ᰝ ࡛ࡣ⣽⬊㉁ෆ㐟㞳ࣜ࣎ࢯ࣮࣒⢒㠃ᑠ⬊యࡢቑຍࡀㄆࡵࡽࢀࠊ⺮ⓑ㉁ྜᡂࡢቑ ᙉࡀ♧၀ࡉࢀࡓࠋࡲࡓࠊ&13DVH ௨እࡢ㧊㠧㛵㐃⺮ⓑ࡛࠶ࡿ 0%3㸪3/3㸪*DO ኚࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ&13DVH ࡣ㧊㠧㍈⣴ࡢ㛫ศᕸࡋ࡚࠸ࡿࡀ㸪 0%3 3/3 ࡣ㧊㠧ศᕸࡋ࡚࠸ࡿࠋࡇࡢศᕸࣃࢱ࣮ࣥࡢ㐪࠸ࡼࡗ࡚㸪0%3 ཬࡧ 3/3 ࡛ࡣኚࡀㄆࡵࡽࢀ࡞ࡗࡓࡶࡢ⪃࠼ࡿࠋࡉࡽ㸪*DO ࡣ⏕ᚋ ᪥ ࡽ ᪥ࡢࣛࢵࢺ࡛ᛴ㏿ቑຍࡋ㸪ṇᖖࡢ⬨㧊࡛ࡶࢇᰁⰍࡉࢀ࡞ࡗࡓ ࡓࡵ㸪 㐌㱋ࡲࡓࡣ 㐌㱋ࡢࣛࢵࢺ࡛ࡣࢇⓎ⌧ࡋ࡚࠸࡞࠸ྍ⬟ᛶࡀ࠶ࡿࠋ &13DVH Ⓨ⌧ࡀᕼ✺㉳⭺⣽⬊ᑐࡍࡿࢽࣜࣥࡢ┤᥋ⓗࡲࡓࡣ㛫᥋ⓗస⏝㉳ᅉ ࡍࡿ࠺ࡣ᫂ࡽ࡛ࡣ࡞࠸ࡀ㸪0%3㸪3/3㸪ࡲࡓࡣ *DO ኚࡀㄆࡵࡽ࡞࠸ ࡶ㛵ࢃࡽࡎ㸪&13DVH ࡛⤒ⓗኚࡀㄆࡵࡽࢀࡓࡇࡽ㸪&13DVH Ⓨ⌧⬨ 㧊ⓑ㉁ࡢᾏ⥥≧ኚࡢ㛫ᐦ᥋࡞㛵ಀࡀ࠶ࡿࡇࡀ♧၀ࡉࢀࡓࠋ. .
(20) ➨ ❶ ࣛࢵࢺ୰ᯡ⚄⤒⣔ࡢ࣊࢟ࢧࢡࣟࣟࣇ࢙ࣥཬࡧ࢝ࣉࣜࢰࣥㄏⓎᛶᾏ⥥≧ኚ ࠾ࡅࡿ &13DVH ࡢ⤒ⓗኚ㛵ࡍࡿ᳨ウ a≉⬻㸪ᑠ⬻㸪⬻ᖿࡘ࠸࡚ࡢ᳨ウa. .
(21) ⥴ゝ ࣊࢟ࢧࢡࣟࣟࣇ࢙ࣥ㸦+&3㸧ࡣ㸪 ᖺ௦▼㮯㸪ᾮయὙ㸪ཬࡧ⢝ရࡢ ᢠ⳦ࡋ࡚࠙㸪ࠚ㸪ࡲࡓ㸪᳜≀ࡢẅ⳦ཬࡧẅࡋ࡚ᗈࡃ⏝ࡉࢀ࡚ ࠸ࡓ࠙㸪㸪ࠚ ࠋࡋࡋ㸪 ᖺ㸪*XPS ࡽࡣ㸪+&3 ࡀ࣐࢘ࢫ㸪ࣛࢵࢺ㸪ࣔ ࣝࣔࢵࢺࡸࢾ࡞ࡢᵝࠎ࡞ື≀ᑐࡋ࡚ẘᛶࡢ࠶ࡿᏛ≀㉁࡛࠶ࡿࡇࢆ♧ ࡋࡓ࠙ࠚࠋࡉࡽ㸪.LPEURXJK *DLQHV࠙ࠚࡣ㸪+&3 ࡼࡗ࡚ࣛࢵࢺࡢ⬻ ⓑ㉁ᾏ⥥≧ኚࡀㄏⓎࡉࢀࡿࡇࢆሗ࿌ࡋࡓࠋ+&3 ࡼࡗ࡚ㄏⓎࡉࢀࡿᾏ⥥ ≧ኚࡣ㸪+&3 ࡀ⬻ෆỈศ㔞ࢆቑຍࡉࡏࡿࡓࡵ㸪ቑຍࡋࡓỈศࡀ㧊㠧㛫ධࡾ ㎸ࡴࡇࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿ⪃ᐹࡉࢀ࡚࠸ࡿ࠙ࠚࠋࡲࡓ㸪ᙉຊ࡞㖡࢟ࣞ ࣮ࢺ࡛࠶ࡿ࢝ࣉࣜࢰࣥ㸦&3=㸧ࡣ㸪࣐࢘ࢫ㸪ࣔࣝࣔࢵࢺࡸࣛࢵࢺࡢ୰ᯡ⚄⤒⣔ ᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࢆకࡗࡓᾏ⥥≧ኚࢆㄏⓎࡍࡿ࠙㸪㸪㸪ࠚ ࠋ ࡉࡽ࣐࢘ࢫ࢝ࣉࣜࢰࣥࢆᢞࡍࡿ⬺㧊๓ᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫ ࡀ㉳ࡇࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ࠙ࠚࡇࡽ㸪&3= ࡢせ࡞ᶆⓗࡣ㸪㧊㠧࡛ࡣ ࡞ࡃᕼ✺㉳⭺⣽⬊࡛࠶ࡿ⪃࠼ࡽࢀ࡚࠸ࡿࠋ ➨ ❶࠾࠸࡚㸪ࢽࣜࣥࢆᗂⱝࣛࢵࢺ༢ᅇᢞࡍࡿࡇࡼࡗ࡚㸪⬨㧊 ⓑ㉁ࡢᾏ⥥≧ኚࡀㄆࡵࡽࢀ㸪ᾏ⥥≧ኚࡀㄆࡵࡽࢀࡿ๓ &13DVH Ⓨ⌧ࡀࣆ࣮ ࢡ㐩ࡋ࡚࠸ࡿࡇࡀุ᫂ࡋࡓࠋࡑࡇ࡛ᮏ❶࡛ࡣ㸪ࢽࣜࣥྠᵝ୰ᯡ⚄⤒ ⣔ᾏ⥥≧ኚࢆㄏⓎࡍࡿࡢྜ≀㸪+&3 ཬࡧ &3= ࢆᗂⱝࣛࢵࢺᢞࡋ㸪 ኚࡀㄏⓎࡉࢀ࡚࠸ࡿࡢ㧊㠧㛵㐃㓝⣲ࡸ⺮ⓑ㸪ࡍ࡞ࢃࡕ㸪&13DVH㸪࣑࢚ࣜࣥ ሷᇶᛶ⺮ⓑ㸦0%3㸧ཬࡧࣉࣟࢸ࢜ࣜࣆࢻ⺮ⓑ㸦3/3㸧ࡀࡢࡼ࠺࡞ᣲືࢆ♧ࡍࡢ ࢆ⌮⤌⧊Ꮫⓗㄪࡓࠋࡲࡓ㸪ᾏ⥥≧ኚࡼࡿ &13DVH Ⓨ⌧ࡢ⤒ⓗኚ ࢆᤊ࠼ࡿࡇࢆ┠ⓗࡋ࡚ᐇ㦂ࢆᐇࡋࡓࠋ ᮏ❶࡛ࡣ࣏ࢺ࣮ࢩࢫࡢ㝿άᛶࡉࢀࡿ &DVSDVH ࢆ⏝࠸࡚㸪ᕼ✺㉳⭺⣽⬊ࡢ .
(22) ࣏ࢺ࣮ࢩࢫࡘ࠸࡚ࡶ᳨ウࡋࡓࠋ. .
(23) ᮦᩱ᪉ἲ ື≀ ᪥㱋ࡢ &UOM :, :LVWDU
(24) ࣛࢵࢺ㸦᪥ᮏࢳ࣮ࣕࣝࢫࣜࣂ࣮㸧 㸪㞤 ༉ཬࡧ ᪥㱋ࡢ &UO &'
(25) 6' ࣛࢵࢺ㸦᪥ᮏࢳ࣮ࣕࣝࢫࣜࣂ࣮㸧 㸪㞝 ༉ࢆᐇ㦂⏝࠸ࡓࠋ ᚤ⏕≀ࣞ࣋ࣝࡣ 63) ࡛࠶ࡗࡓࠋࣛࢵࢺࡣ㸪 ᗘ s Υ㸪‵ᗘ s 㸣㸪 Ẽ ᅇ㸭㛫㸪↷᫂㛫 㛫㸭᪥⥔ᣢࡉࢀࡓື≀ᐊ࠾࠸࡚㸪࣏ࣜ࢝ ࣮࣎ࢿ࣮ࢺࢣ࣮ࢪ࡚㣫⫱ࡋ㸪 ȣP ࣇࣝࢱ࣮ℐ㐣ᚋ⣸እ⥺↷ᑕࡋࡓỈ㐨Ỉ ᨺᑕ⥺⁛⳦῭ࡳࡢᐇ㦂ື≀⏝ᅛᙧ㣫ᩱ 0) ࠶ࡿ࠸ࡣᐇ㦂ື≀⏝⢊ᮎ㣫ᩱ &) 㸦࢚࢜ࣜࣥࢱࣝ㓝ẕ㸧ࢆ⮬⏤ᦤྲྀࡉࡏࡓࠋ ྜ≀ +&3㸦&+&O2㸪&$6 ␒ྕ ̽㸧࠾ࡼࡧ &3=㸦&+12㸪&$6 ␒ྕ ̽㸧ࡣ㸪6LJPD$OGULFK ♫㸦ᮾி㸪᪥ᮏ㸧ࡽධᡭࡋࡓࠋ+&3 ࡣ 㸣࢝ࣝ࣎࢟ ࢩ࣓ࢳࣝࢭ࣮ࣝࣟࢫ1D㸦&0&1D㸧୰ࡢ PJPO ࡞ࡿࡼ࠺ㄪᩚࡋࡓࠋ&3= ࢆᐇ㦂ື≀⏝⢊ᮎ㣫ᩱ㸦&)ࠊ࢚࢜ࣜࣥࢱࣝ㓝ẕ㸧ΰྜࡋ࡚㸪ZZ㸣ࡢᆒ୍ ࡞ΰྜ≀ࢆㄪ〇ࡋࡓࠋ ᐇ㦂ࣉࣟࢺࢥ࣮ࣝ +&3 ᢞᐇ㦂㸸ࣛࢵࢺࢆయ㔜࡛ᒙูࡋ㸪+&3 㠀ᢞ⩌㸦ᑐ↷⩌㸧ᢞ⩌ ศࡅ㸪ࡉࡽᏳᴦṚ᪥ࢆࣛࣥࢲ࣒ࡾᙜ࡚ࡓࠋື≀ࡣ㸪ᙉไ⤒ཱྀࡼࡾ &0&1D㸦ᑐ↷⩌㸧ࡲࡓࡣ PJNJ ࡢ +&3㸦ᢞ⩌㸧ࢆ ᪥㛫⤒ཱྀᢞࡋ ࡓࠋ⏝㔞ࡣ㸪௨๓ࡢሗ࿌ࡢ⤖ᯝᇶ࡙࠸࡚Ỵᐃࡋࡓ࠙㸪ࠚࠋᐇ㦂ࢹࢨࣥࢆ 7DEOH ♧ࡍࠋື≀ࡣ㸪࣌ࣥࢺࣂࣝࣅࢱ࣮ࣝࢼࢺ࣒ࣜ࢘㸦ࢿࣥࣈࢱ࣮ࣝὀᑕ㸪 .
(26) ᪥ᮏఫ〇⸆ᰴᘧ♫㸧ࡢ⭡⭍ෆὀᑕࡼࡿ㯞㓉ୗ࠾࠸࡚㸪ᕥᚰᐊࡽ 㸣 ࣃ࣒ࣛ࣍ࣝࣝࢹࣄࢻỈ⁐ᾮࢆ℺ὶࡋ㸪ྑᚰᡣࡽࡢᨺ⾑ࡼࡾᢞ 㸪㸪 ཬࡧ ᪥┠ࡢ࠸ࡎࢀ࡛ᏳᴦṚࡉࡏࡓࠋ ᪥㛫ࡢ⤒ཱྀᢞᚋ㸪 ᪥㛫ࡢᅇ ᮇ㛫㸦 ᪥┠㸧ࢆタࡅࡓࠋ࡞࠾㸪ᢞึ᪥ࢆ ᪥┠ࡋࡓࠋ &3= ᢞᐇ㦂㸸ࣛࢵࢺࢆయ㔜࡛ᒙูࡋ㸪&3= 㠀ᢞ⩌㸦ᑐ↷⩌㸧ᢞ⩌ ศࡅ㸪ࡉࡽᏳᴦṚ᪥ࢆࣛࣥࢲ࣒ࡾᙜ࡚ࡓࠋື≀ࡣ㸪ᐇ㦂ື≀⏝⢊ᮎ 㣫ᩱ &)㸦ᑐ↷⩌㸧ࡲࡓࡣ &3=ZZΰྜ㣫ᩱ㸦ᢞ⩌㸧ࢆ ᪥㛫⤒ཱྀᦤྲྀࡉ ࡏࡓࠋ⏝㔞ࡣ㸪௨๓ࡢሗ࿌ࡢ⤖ᯝᇶ࡙࠸࡚Ỵᐃࡋࡓ࠙㸪ࠚࠋᐇ㦂ࢹࢨࣥࢆ 7DEOH ♧ࡍࠋ+&3 ᢞᐇ㦂ྠᵝື≀ࡣ㯞㓉ୗ࠾࠸࡚㸪ᕥᚰᐊࡽ 㸣 ࣃ࣒ࣛ࣍ࣝࣝࢹࣄࢻỈ⁐ᾮࢆ℺ὶࡋ㸪ྑᚰᡣࡽࡢᨺ⾑ࡼࡾᢞ 㸪㸪 ཬࡧ ᪥┠ࡢ࠸ࡎࢀ࡛ᏳᴦṚࡉࡏࡓࠋ ᪥㛫ࡢ⤒ཱྀᦤྲྀᚋ㸪 ᪥㛫ࡢᅇᮇ 㛫㸦 ᪥┠㸧ࢆタࡅࡓࠋ࡞࠾㸪ᢞึ᪥ࢆ ᪥┠ࡋࡓࠋ ⤌⧊Ꮫⓗ᳨ᰝ +&3 ཬࡧ &3= ᢞᐇ㦂ࡶ㸪ࡍ࡚ࡢࣛࢵࢺࡽ⬻㸪⬨㧊㸪୕ཫ⚄⤒㸪ᆘ 㦵⚄⤒ࢆ᥇ྲྀࡋ㸪㸣୰ᛶ⦆⾪࣐࡛࣍ࣝࣜࣥᅛᐃࡋࡓࠋᅛᐃࡋࡓ⬻ཬࡧ⬨㧊ࡣ㸪 ᐃἲᚑࡗ࡚㸪ᶓ᩿㠃ࡘ࠸࡚㸪ࣃࣛࣇࣥໟᇙࡋ࡚ษ∦ࢆస〇ࡋࡓࠋษ∦ࡣ +(ᰁⰍࢆࡋ࡚⤌⧊Ꮫⓗほᐹࡋࡓࠋࡲࡓ㸪ኚࡢ⛬ᗘࡀᙉࡗࡓ⬻ࡘ࠸࡚㸪 චᰁⰍࢆᐇࡋࡓࠋ ୍ḟᢠయࡋ࡚㸪ࣄࢺ &13DVH㸦 &KHPLFRQ,QWHUQDWLRQDO ,QF7HPHFXOD&$86$㸧㸪ࣄࢺ 0%3㸦 6HURWHF/WG2[IRUG(QJODQG
(27) 㸧 㸪PLP 㸦1㸸200㸪Millipore, Billerica, MA, U.S.A.㸧ཬࡧ $FWLYDWHG&DVSDVH㸦㸸 ᕼ㔘ࠊ. 0LOOLSRUH%LOOHULFD0$86$
(28) ࢆ⏝ࡋࡓࠋᢠཎ㈿ά㛵ࡋ࡚ࡣ㸪ࢫࣛࢻࢆ 㸣࣒ࣀࢭ࣮ࣂ࣮㸦᪥Ύ (0 ♫㸪ᮾி㸪᪥ᮏ㸧⛣ࡋ㸪:0: ࣉࣟࢭࢵ ࢧ࣮㸦0,㸪ᮾᒇ㸪ᮾி㸪᪥ᮏ㸧࡛ Υࠊ ศ㛫ࠊ࣐ࢡ࢙࣮ࣟ࢘ࣈฎ⌮ࢆ .
(29) ࡋࡓࠋ ᾏ⥥≧ኚࡢ⛬ᗘࢆ ࡘࡢࢢ࣮ࣞࢻཬࡧ &13DVH චᰁⰍࡢ⛬ᗘࢆ ࡘࡢࢢࣞ ࣮ࢻศ㢮ࡋ㸪⣔ิ࡛ホ౯ࡋࡓࠋᾏ⥥≧ኚཬࡧ &13DVH චᰁⰍࡣ㸪௨ୗࡢ ࡼ࠺ࢢ࣮ࣞࢹࣥࢢࡋࡓࠋᾏ⥥≧ኚࡢሙྜ㸪ࢫࢥ 㸸ኚࡀ࡞ࡋ㸦㸧 㸪ࢫ ࢥ 㸸ⓑ㉁ᑠᆺࡢ✵⬊ࡀᩓᅾ㸦㸧㸪ࢫࢥ 㸸ⓑ㉁ᑠᆺࡽ୰ᆺࡢ✵⬊ࡀ ࡧࡲࢇᛶㄆࡵࡽࢀࡿ㸦㸧㸪ࢫࢥ 㸸ⓑ㉁ᆺࡢ✵⬊ࡀࡧࡲࢇᛶㄆࡵࡽ ࢀࡿ㸦㸧 ࠋ&13DVH චᰁⰍࡢሙྜ㸪ࢫࢥ 㸸ᑠᆺࡢᕼ✺㉳⭺⣽⬊࡛⣽⬊㉁ ቃ⏺ἢࡗ࡚ࢃࡎ㝧ᛶᛂࡀほᐹࡉࢀࡿ㸦㸧㸪ࢫࢥ 㸸୰➼ᗘࡢ㝧ᛶᛂ ࡀ㸪ᕼ✺㉳⭺⣽⬊ࡢ㍍ᗘ⭘ࡋࡓ⣽⬊㉁య࡛ほᐹࡉࢀࡿ㸦㸧 㸪ࢫࢥ 㸸 㔜ᗘࡢ㝧ᛶᛂࡀ㸪ᕼ✺㉳⭺⣽⬊ࡢ㍍ᗘ⭘ࡋࡓ⣽⬊㉁య࡛ほᐹࡉࢀࡿ 㸦㸧 ࠋ࠸ࡎࢀࡢホ౯ࡶࢫࢥࡢᖹᆒ್ࢆ⟬ฟࡋࡓࠋ 㟁Ꮚ㢧ᚤ㙾Ꮫⓗ᳨ᰝ ኚࡢ⛬ᗘࡀᙉࡗࡓ⬻㸦⬻⓶㉁㸪⬻ᱱཬࡧ⥺᮲య㸧ࡢ⤌⧊∦ࢆ 㸣ࣃࣛ࣍ ࣒ࣝࣝࢹࣄࢻỈ⁐ᾮ࡛⣙ 㛫ᅛᐃࡋ㸪㸣ᅄ㓟࢜ࢫ࣑࣒࡛࢘ 㛫ᚋᅛ ᐃࡋࡓࠋࡑࡢᚋ㸪࢚࣏࢟ࢩᶞ⬡ໟᇙࡋ㸪ཌษࡾษ∦స〇ᚋ㸪ࢺࣝࢪࣥࣈ࣮ࣝ ࡛ᰁⰍࡋࡓࠋ㉸ⷧษ∦ࢆస〇ࡋ㸪㓑㓟࢘ࣛࢽࣝཬࡧࢡ࢚ࣥ㓟㖄ࡼࡿ㔜ᰁⰍ ࢆࡋࡓᚋ㸪㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾㸦+㸪᪥❧㸪ᮾி㸪᪥ᮏ㸧࡛ほᐹࡋࡓࠋ ࡇࡢᐇ㦂ࡣࠕື≀ᐇ㦂㛵ࡍࡿᣦ㔪㸦ᰴᘧ♫㹊㹑㹇࣓ࢹ࢚ࣥࢫ ⸆ᨭ ᴗᮏ㒊 ヨ㦂◊✲ࢭࣥࢱ࣮㸧 ࠖᇶ࡙ࡁ㸪㮵ᓥ◊✲ᡤື≀ᐇ㦂ጤဨࡢᢎㄆ ࢆᚓ࡚ᐇࡋࡓࠋ. .
(30) ⤖ᯝ ⤌⧊Ꮫⓗ᳨ᰝ ኚࡢ⤒ⓗኚ +&3 ᢞᐇ㦂㸸⌮⤌⧊Ꮫⓗ ᪥┠࡛ࡣ␗ᖖࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ ᪥┠ ࡽ ᪥㸦ᅇ ᪥㸧┠ࡅ࡚࣭ᑠ⬻㸪ᘏ㧊ཬࡧ⬨㧊ࡢⓑ㉁ᾏ⥥≧ኚ ࡀㄆࡵࡽࢀࡓ㸦ᅗ 㸧ࠋᾏ⥥≧ኚࡣ㸪≉⬻ࡢ⬻ᱱཬࡧᑠ⬻ⓑ㉁࡛ኚ⛬ᗘ ࡀᙉࡗࡓࠋࡲࡓ㸪 ᪥┠ࡽ ᪥┠࡛ࡣ㸪࣭ᑠ⬻ཬࡧᘏ㧊࠾࠸࡚㸪ᕼ✺㉳ ⭺⣽⬊ࡢ᰾⃰⦰ࢆక࠺ኚᛶࡀㄆࡵࡽࢀࡓ㸦ᅗ LQVHW㸧 ࠋ ᪥┠࡛ࡣ㸪ᾏ⥥≧ኚ ཬࡧᕼ✺㉳⭺⣽⬊ࡢ᰾⃰⦰ࡢ⛬ᗘࡣ㸪᭱ࡶ㢧ⴭ࡛࠶ࡗࡓࠋࡋࡋ࡞ࡀࡽ㸪 ᪥ 㸦ᅇ ᪥㸧┠࡛ࡣ㸪ᾏ⥥≧ኚࡢ⛬ᗘࡣῶᙅࡋ㸪ᕼ✺㉳⭺⣽⬊ࡢኚࡣᅇ ࡋࡓࠋ &3= ᢞᐇ㦂㸸⬻ཬࡧᑠ⬻ࡢⓑ㉁㸪୪ࡧ⬻⓶㉁ᾏ⥥≧ኚࡀ ᪥┠ ࡽ ᪥┠ㄆࡵࡽࢀࡓࠋ ᪥┠ኚ⛬ᗘࡀࣆ࣮ࢡ㐩ࡋࡓࠋࡋࡋ㸪&3= ᢞ ࣛࢵࢺࡢᾏ⥥≧ኚࡣ㸪+&3 ᢞࣛࢵࢺࡢᾏ⥥≧ኚࡼࡾࡶࢃࡎ㍍ࡗ ࡓࠋࡲࡓ㸪 ᪥㸦ᅇ ᪥㸧┠㸪ᾏ⥥≧ኚࡣᅇࡋࡓࠋࡉࡽ ᪥ ࡽ ᪥┠ࡅ࡚㸪⬻⓶㉁ࡸⓑ㉁࡛ࡣ㸪ᕼ✺㉳⭺⣽⬊ࡢ᰾㸪⣽⬊㉁ࡶ ⃰⦰ࡋ㸪ኚᛶࡋ࡚࠸ࡿࡶࡢࡸ᰾ࡣ⃰⦰ࡋ㸪⣽⬊㉁ࡣዲ㓟ᛶࢆ♧ࡍ࣏ࢺ࣮ࢩࢫ ീࡀㄆࡵࡽࢀࡓ㸦ᅗ $&㸧ࠋ࣏ࢺ࣮ࢩࢫࡣ ᪥┠࡛᭱ࡶ㢧ⴭ࡛࠶ࡗࡓ 㸦ᅗ %㸧ࠋ &13DVH Ⓨ⌧ࡢ⤒ⓗኚ +&3 ᢞᐇ㦂㸸&13DVH චᰁⰍ࠾࠸࡚㸪⤒ⓗኚࡀㄆࡵࡽࢀࡓࠋࡋࡋ ࡞ࡀࡽ㸪0%3㸪3/3 ཬࡧ &DVSDVH චᰁⰍ࡛ࡣఱࡽኚࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ .
(31) ᑐ↷⩌࡛ࡣ㸪&13DVH 㝧ᛶᛂࡀ⬻⓶㉁ࡢᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ࢆ⦕ྲྀࡿࡼ࠺ ㄆࡵࡽࢀࡓ㸦ᅗ '㸧 ࠋ+&3 ᢞࣛࢵࢺ࡛ࡣ㸪 ᪥┠ࡽ ᪥┠ࡲ࡛ࡣᕼ✺㉳ ⭺⣽⬊ࡢ⣽⬊⭷ࢆ⦕ྲྀࡿࡼ࠺ &13DVH 㝧ᛶീࡀㄆࡵࡽࢀ㸪ᑐ↷⩌ࡢᕪࡣㄆࡵ ࡽࢀ࡞ࡗࡓ㸦ᅗ (㸧ࠋ ᪥㸦ᅇ ᪥㸧┠࡛ࡣ㸪⬻⓶㉁ࡢ୍㒊ࡢᕼ✺㉳ ⭺⣽⬊࡛ &13DVH ࡀ⭘ࡋࡓ⣽⬊㉁యᙉ㝧ᛶࢆ♧ࡋࡓ㸦ᅗ )㸧ࠋ୍᪉㸪ⓑ ㉁࡛ࡣ &13DVH ࡢᙉ㝧ᛶീࡣㄆࡵࡽࢀ࡞ࡗࡓࠋᅗ ࡣ㸪ⓑ㉁࠾ࡅࡿᾏ⥥≧ኚ ཬࡧ⬻⓶㉁ࡢ &13DVH චᰁⰍࡢ⤒ⓗ࡞ኚࢆ♧ࡋࡓࡶࡢ࡛࠶ࡿࠋ &13DVH Ⓨ⌧ࡣ ᪥㸦ᅇ ᪥㸧┠ࣆ࣮ࢡ㐩ࡋࡓࠋ &3= ᢞᐇ㦂㸸&13DVH㸪0%3 ཬࡧ &DVSDVH චᰁⰍ࠾࠸࡚㸪⤒ⓗኚ ࡀㄆࡵࡽࢀࡓࠋ3/3 චᰁⰍ࡛ࡣఱࡽኚࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ&13DVH චᰁ Ⰽ࡛ࡣ㸪&3= ᢞࣛࢵࢺ࡛ ᪥┠ࡽ ᪥┠ࡲ࡛⬻⓶㉁ࡢᕼ✺㉳⭺⣽⬊ ࠾࠸࡚㸪⭘ࡋࡓ⣽⬊㉁య୰➼ᗘࡽ㔜ᗘࡢ㝧ᛶീࡀㄆࡵࡽࢀࡓ 㸦ᅗ *+㸧ࠋ ᪥㸦ᅇ ᪥㸧┠࡛ࡣ㸪&13DVH 㝧ᛶീࡣᑐ↷⩌ྠᵝᕼ ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ࢆ⦕ྲྀࡿࡼ࠺ㄆࡵࡽࢀࡓ㸦ᅗ ,㸧ࠋⓑ㉁࠾ࡅࡿ &13DVH 㝧ᛶᛂࡣ㸪ྛ᳨⣴࣏ࣥࢺ࡛ఱࡽኚࡣㄆࡵࡽࢀ࡞ࡗࡓࠋᅗ ࡣⓑ㉁࠾ ࡅࡿᾏ⥥≧ኚཬࡧ⬻⓶㉁ࡢ &13DVH චᰁⰍࡢ⤒ⓗ࡞ኚࢆ♧ࡋࡓࡶࡢ ࡛࠶ࡿࠋ&13DVH ࡢⓎ⌧ࡣ ᪥┠ࡽㄆࡵࡽࢀ㸪 ᪥┠ࣆ࣮ࢡ㐩ࡋࡓࠋ ᪥ 㸦ᅇ ᪥㸧┠࡛ࡣ㸪&13DVH 㝧ᛶീࡣᑐ↷⩌ྠᵝᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ ࢆ⦕ྲྀࡿࡼ࠺ㄆࡵࡽࢀࡓࠋ0%3 චᰁⰍ࡛ࡣ㸪ᑐ↷⩌࠾࠸࡚㸪⬻ᱱཬࡧ⥺ ᮲యࡢ⚄⤒⥺⥔ࡀ㝧ᛶࢆ♧ࡋࡓ㸦ᅗ -㸧ࠋ&3= ᢞࣛࢵࢺ࡛ࡣ㸪⬻ⓑ㉁㸪≉ ⬻ᱱ⥺᮲యࡢ 0%3 㝧ᛶീࡀ ᪥┠ࡽ ᪥┠࡛ࡣῶᑡࡋ࡚࠸ࡓ㸦ᅗ .㸧 ࡀ㸪 ᪥㸦ᅇ ᪥㸧┠ࡣᅇࡋࡓ㸦ᅗ /㸧ࠋ&DVSDVH චᰁⰍ࡛ࡣ㸪ᑐ ↷⩌࡛ࡣ㝧ᛶᛂࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ&3= ᢞࣛࢵࢺ࡛ࡣ㸪 ᪥┠ࡽ ᪥┠ ⬻⓶㉁ཬࡧ⬻ᱱ࡛㝧ᛶീࡀㄆࡵࡽࢀ㸦ᅗ 01㸧㸪≉ ᪥┠࡛ࡣ㸪ከᩘ .
(32) ࡢᕼ✺㉳⭺⣽⬊ &DVSDVH 㝧ᛶീࡀㄆࡵࡽࢀࡓ㸦ᅗ 1㸧 ࠋ ᪥㸦ᅇ ᪥㸧 ┠࡛ࡣ㸪ᕼ✺㉳⭺⣽⬊ࡢ &DVSDVH 㝧ᛶീࡣᑡᩘ࡛࠶ࡗࡓ㸦ᅗ 2㸧 ࠋ 㟁Ꮚ㢧ᚤ㙾Ꮫⓗ᳨ᰝ +&3 ᢞᐇ㦂㸸⬻⓶㉁㸪⬻ᱱཬࡧ⥺᮲య࠾࠸࡚㸪㧊㠧ࡢゎ㞳ཬࡧᕼ✺㉳ ⭺⣽⬊ࡢ⣽⬊㉁ࡢỈ⭘ᛶ⭘ࡀ ᪥┠௨㝆ㄆࡵࡽࢀࡓࠋ ᪥┠࡛ࡣ㸪⬻ᱱ 㸦ᅗ $㸧ཬࡧ⬻⓶㉁㸦ᅗ %㸧࡛㧊㠧ࡢゎ㞳ࡢ⛬ᗘཬࡧⓎ⏕ࡀ㢧ⴭቑຍࡋ ࡓࠋࡉࡽ㸪⬻⓶㉁࡛ࡣᶞ≧✺㉳㍈⣴ࡢỈ⭘ᛶ⭘ࡶㄆࡵࡽࢀࡓ㸦ᅗ %㸧ࠋ ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁ࡢ⭘ࡣ㸪⬻ᱱ㸦ᅗ &㸧㸪⬻⓶㉁㸦ᅗ '㸧ཬࡧ⥺᮲ య࡛᭱ࡶ㢧ⴭ࡛࠶ࡗࡓࠋ ᪥┠࡛ࡣ㸪⬻ᱱ࠾ࡅࡿ㧊㠧ࡢゎ㞳ཬࡧᕼ✺㉳⭺⣽ ⬊ࡢ⭘ࡢ⛬ᗘཬࡧⓎ⏕ࡣῶᑡࡋࡓࠋࡲࡓ㸪⬻⓶㉁࡛ࡣ㸪ᕼ✺㉳⭺⣽⬊ࡢ⣽ ⬊㉁㸪ᶞ≧✺㉳ཬࡧ㍈⣴ࡢ⭘ࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ &3= ᢞᐇ㦂㸸⬻⓶㉁㸦ᅗ $㸧ཬࡧ⬻ᱱ࠾ࡅࡿ㧊㠧ࡢゎ㞳ࡣ ᪥┠ ࡽ ᪥┠࡛ㄆࡵࡽࢀࡓࠋ ᪥┠ࡽ ᪥┠࡛ࡣ㸪⬻ᱱࡢᕼ✺㉳⭺⣽⬊ࡣ㸪࣏ ࢺ࣮ࢩࢫᑠయࢆకࡗࡓ᩿∦ࡋࡓ᰾⃰⦰ࡋࡓ⣽⬊㉁ࢆ᭷ࡍࡿ࣏ࢺ࣮ࢩࢫࡢ ീࢆ♧ࡋ࡚࠸ࡓࠋ ᪥┠࡛ࡣ㸪⬻ᱱከᩘࡢ࣏ࢺ࣮ࢩࢫീࡀㄆࡵࡽࢀࡓ 㸦ᅗ %㸧ࠋ⥺᮲యࡢ⥺⥔᮰࡛ࡣ㸪᭷㧊⚄⤒⥺⥔ࡢᩘᚄࡢῶᑡࡀ㢧ⴭ࡛࠶ࡾ㸪 ከࡃࡢ↓㧊⚄⤒⥺⥔ࡀ ᪥┠ࡽ ᪥┠ࡅ࡚ㄆࡵࡽࢀࡓ㸦ᅗ &㸧ࠋ ᪥┠ ࡛ࡣ㸪⬻⓶㉁㸪⬻ᱱཬࡧ⥺᮲య࠾࠸࡚㸪㧊㠧ࡢゎ㞳ࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ ࡋࡋ࡞ࡀࡽ㸪࠸ࡃࡘࡢᕼ✺㉳⭺⣽⬊ࡣ࣏ࢺ࣮ࢩࢫീࢆ♧ࡋ࡚࠸ࡓࠋ. .
(33) ⪃ᐹ &13DVH ࡣ㸪ᕼ✺㉳⭺⣽⬊ࡢ✺㉳ࡢఙ㛗ᐦ᥋㛵ࡋ࡚࠸ࡿࡇࡀሗ࿌ࡉࢀ ࡚࠸ࡿ࠙ࠚ ࠋࡇࡢࡇࡽ㸪+&3 ᢞࣛࢵࢺ࠾ࡅࡿ &13DVH ࡢⓎ⌧ࡣ㸪+&3 ࡼࡿᕼ✺㉳⭺⣽⬊ཬࡧ㧊㠧ࡢയᐖᚋࡢᅇ㛵㐃ࡋ࡚ቑຍࡋࡓࡶࡢ⪃࠼ ࡿࠋ୍᪉㸪&3= ᢞࣛࢵࢺ࡛ࡣ㸪&13DVH Ⓨ⌧ࡣ㸪ᾏ⥥≧ኚࡢ㐍⾜ࡶቑ ຍࡋࡓࠋࡘࡲࡾ㸪&3= ᢞࣛࢵࢺࡢ &13DVH Ⓨ⌧ቑຍࡢᮇࡣ㸪+&3 ᢞࣛࢵ ࢺࡢⓎ⌧ቑຍࡢᮇࡣ␗࡞ࡗ࡚࠸ࡓࠋࡋࡓࡀࡗ࡚㸪&13DVH ࡢᙺࡣ༢୍࡛ࡣ ࡞࠸ࡇࡀ♧၀ࡉࢀࡓࠋࡲࡓ㸪&3= ㄏⓎᛶ⬺㧊ࣛࢵࢺࣔࢹ࡛ࣝࡣ㸪ᛴᛶᮇ⬺㧊 ୰㒊ศⓗ㧊㠧ࡀ㉳ࡇࡿࡇࡣࡼࡃ▱ࡽࢀ࡚࠸ࡿ࠙ࠚࠋ&13DVH ࡣ &3= ᢞ ࣛࢵࢺࡢᾏ⥥≧ኚࡢ㐍⾜୰㉳ࡁࡿ㒊ศⓗ࡞㧊㠧ᑐࡋ࡚㸪ఱࡽࡢ ᙺࢆᯝࡓࡍྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࡀ㸪ᮏ◊✲ࡢ⤖ᯝࡣࡇࡢ᥎ᐹࢆࡅࡿࡢ ༑ศ࡛ࡣ࡞ࡗࡓࠋ +&3 ᢞࣛࢵࢺㄆࡵࡽࢀࡓኚศᕸࡣ㸪㐣ཤࡢሗ࿌࠙㸪㸪㸪㸪㸪 ࠚࡢグ㍕୍⮴ࡋ࡚࠸ࡓࠋ+&3 ࡼࡗ࡚ㄏⓎࡉࢀࡿ㧊㠧ࡢゎ㞳ࡣ㸪⬻ෆỈศ 㔞ࢆቑຍࡉࡏࡿࡓࡵ㸪ቑຍࡋࡓỈศࡀ㧊㠧㛫ධࡾ㎸ࡴࡇࡼࡗ࡚ᘬࡁ㉳ࡇ ࡉࢀࡿ⪃ᐹࡉࢀ࡚࠸ࡿ࠙ࠚ ࠋᮏ◊✲࡛ࡣ㸪㧊㠧ࡢゎ㞳ຍ࠼࡚㸪ᶞ≧✺㉳ཬ ࡧ㍈⣴ࡢỈ⭘ᛶ⭘ࡀ ᪥┠ࡽ ᪥┠ほᐹࡉࢀࡓࠋࡋࡓࡀࡗ࡚㸪ᮏ◊✲࡛ ㄆࡵࡽࢀࡓᾏ⥥≧ኚࡶ㸪ୖ㏙ྠᵝࡢ࣓࢝ࢽࢬ࣒ࡼࡗ࡚ㄏⓎࡉࢀࡓࡶࡢ ⪃࠼ࡿࠋ&3= ᢞࣛࢵࢺ࡛ࡣ㸪ᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࢆకࡗࡓᾏ⥥≧ኚ ࡀㄆࡵࡽࢀ㸪ࡇࡢ⤖ᯝࡣ㐣ཤࡢሗ࿌୍⮴ࡋ࡚࠸ࡓ࠙㸪㸪㸪ࠚࠋᮏ◊✲ ࡛ࡣᾏ⥥≧ኚཬࡧ࣏ࢺ࣮ࢩࢫࡀ᭱ࡶ㢧ⴭ࡛࠶ࡗࡓࡢࡣ㸪ྠࡌᮇ࡛࠶ࡗࡓࠋ ࡋࡋ㸪࣐࢘ࢫ &3= ࢆᢞࡍࡿ⬺㧊๓ᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡀ㉳ ࡇࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿࡇࡽ࠙ࠚ㸪ᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡼࡾ. .
(34) ᾏ⥥≧ኚࡀ㉳ࡁ࡚࠸ࡿࡶࡢ⪃࠼ࡿࠋࡲࡓ㸪+&3 &3= ࡼࡿᾏ⥥≧ኚࡢ ࣓࢝ࢽࢬ࣒ࡣ␗࡞ࡗ࡚࠸ࡿࡇࡽ㸪ᾏ⥥≧ኚࡢ࣓࢝ࢽࢬ࣒ࡢ㐪࠸ࡀ㸪+&3 ᢞࣛࢵࢺ &3= ᢞࣛࢵࢺࡢ &13DVH Ⓨ⌧㐪࠸ࢆᘬࡁ㉳ࡇࡋࡓྍ⬟ᛶࡀ࠶ ࡿ⪃࠼ࡿࠋ 0%3 චᰁⰍ࡛ࡣ㸪&3= ᢞࣛࢵࢺࡢ⬻ᱱཬࡧ⥺᮲య࡛㝧ᛶീࡀῶᑡࡋ࡚࠸ ࡓࠋ&3= ㄏⓎᛶ⬺㧊ࣛࢵࢺࣔࢹࣝ࠾࠸࡚㸪㧊㠧ࢆᵓᡂࡍࡿ⺮ⓑ㸪ࣜࣥ⬡㉁ཬ ࡧ࢞ࣛࢡࢺ⬡㉁ࡀྛࠎ㸪 ཬࡧ ῶᑡࡋࡓࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ࠙㸪㸪 ࠚࠋࡋࡓࡀࡗ࡚㸪㧊㠧ࢆᵓᡂࡍࡿ⺮ⓑ࡛࠶ࡿ 0%3࠙ࠚࡀῶᑡࡋࡓࡇࢆᫎ ࡋ࡚࠸ࡿࡶࡢ⪃࠼ࡿࠋ &13DVH Ⓨ⌧ࡣ㸪+&3 ᢞ࡛ࡣᕼ✺㉳⭺⣽⬊ཬࡧ㧊㠧ࡢയᐖᚋࡢಟ㐣⛬ཬ ࡧ &3= ᢞ࡛ࡣᕼ✺㉳⭺⣽⬊ࡢയᐖࡼࡿᾏ⥥≧ኚࡢ㐍⾜㐣⛬࡛ቑᙉࡍࡿ ࡇࡀ᫂ࡽ࡞ࡗࡓࠋ&13DVH Ⓨ⌧ࡢ⤒ⓗኚࡢ㐪࠸ࡣ㸪+&3 ཬࡧ &3= ᢞ ࣛࢵࢺ࠾ࡅࡿᾏ⥥≧ኚࡢ࣓࢝ࢽࢬ࣒ࡀ␗࡞ࡿࡇ㉳ᅉࡍࡿࡶࡢ⪃࠼ ࡿࠋ. .
(35) ᑠᣓ +&3 ᢞ࡛ࡣᾏ⥥≧ኚࡣ㸪≉⬻ࡢ⬻ᱱཬࡧᑠ⬻ⓑ㉁࡛ኚ⛬ᗘࡀᙉ ࡗࡓࠋࡲࡓ㸪ᕼ✺㉳⭺⣽⬊ࡢ᰾⃰⦰ࢆక࠺ኚᛶࡀㄆࡵࡽࢀࡓࠋ&3= ᢞ࡛ࡣ ⬻ཬࡧᑠ⬻ࡢⓑ㉁㸪୪ࡧ⬻⓶㉁ᾏ⥥≧ኚࡀㄆࡵࡽࢀࡓࠋࡲࡓ㸪ᕼ✺㉳ ⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡶᾏ⥥≧ኚྠࡌᮇኚ⛬ᗘࡀࣆ࣮ࢡ㐩ࡋࡓࠋ &13DVH Ⓨ⌧ࡣ㸪+&3 ᢞ࡛ࡣᕼ✺㉳⭺⣽⬊ཬࡧ㧊㠧ࡢയᐖᚋࡢಟ㐣⛬ཬࡧ &3= ᢞ࡛ࡣᕼ✺㉳⭺⣽⬊ࡢയᐖࡼࡿᾏ⥥≧ኚࡢ㐍⾜㐣⛬࡛ቑᙉࡍࡿࡇ ࡀ᫂ࡽ࡞ࡗࡓࠋ&13DVH Ⓨ⌧ࡢ⤒ⓗኚࡢ㐪࠸ࡣ㸪+&3 ཬࡧ &3= ᢞ ࣛࢵࢺ࠾ࡅࡿᾏ⥥≧ኚࡢ࣓࢝ࢽࢬ࣒ࡀ␗࡞ࡿࡇ㉳ᅉࡍࡿࡶࡢ⪃࠼ࡿࠋ +&3 ᢞ࡛ࡣ &13DVH ௨እࡢ㧊㠧㛵㐃⺮ⓑኚࡀㄆࡵࡽࢀ࡞ࡗࡓࠋ୍᪉㸪 &3= ᢞ࡛ࡣ㸪0%3 චᰁⰍ࠾࠸࡚㸪⬻ᱱཬࡧ⥺᮲య࡛ᰁⰍᛶࡀῶᑡࡋ࡚࠸ ࡓࠋ&3= ㄏⓎᛶ⬺㧊ࣛࢵࢺࣔࢹࣝ࠾࠸࡚㸪㧊㠧ࢆᵓᡂࡍࡿ⺮ⓑ㸪ࣜࣥ⬡㉁ཬ ࡧ࢞ࣛࢡࢺ⬡㉁ࡀྛࠎ㸪 ཬࡧ ῶᑡࡋࡓࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡋࡓࡀ ࡗ࡚㸪㧊㠧ࡢࡓࡿᵓᡂ⺮ⓑ࡛࠶ࡿ 0%3 ࡀῶᑡࡋࡓࡇࢆᫎࡋ࡚࠸ࡿࡶࡢ ⪃࠼ࡿࠋ. .
(36) ➨ ❶ ࣛࢵࢺ୰ᯡ⚄⤒⣔ࡢ࣊࢟ࢧࢡࣟࣟࣇ࢙ࣥཬࡧ࢝ࣉࣜࢰࣥㄏⓎᛶᾏ⥥≧ኚ ࠾ࡅࡿ &13DVH ࡢ⤒ⓗኚ㛵ࡍࡿ᳨ウ a⬨㧊ࡘ࠸࡚ࡢ᳨ウa .
(37) ⥴ゝ ➨ ❶࠾࠸࡚㸪ᕼ✺㉳⭺⣽⬊ཬࡧ㧊㠧ࡢയᐖ㸪୪ࡧ᫂☜࡞ᾏ⥥≧ኚࡀ ㄆࡵࡽࢀࡓ⬻㸪ᑠ⬻ཬࡧᘏ㧊࠾࠸࡚㸪⤒ⓗ &13DVH Ⓨ⌧ࣃࢱ࣮ࣥࡀ␗࡞ ࡿࡇࢆ♧ࡋࡓࠋࡍ࡞ࢃࡕ㸪&13DVH ࡢⓎ⌧ࡣ +&3 ᢞ࡛ࡣᕼ✺㉳⭺⣽⬊ࡸ㧊㠧 ࡢയᐖᚋࡢಟ㐣⛬ቑᙉࡋ㸪&3= ᢞ࡛ࡣᕼ✺㉳⭺⣽⬊ࡢയᐖࡼࡿᾏ⥥ ≧ኚࡢ㐍⾜㐣⛬ቑᙉࡍࡿࡇࢆ᫂ࡽࡋࡓࠋࡲࡓ㸪+&3 ࡼࡗ࡚ㄏⓎࡉ ࢀࡿᾏ⥥≧ኚࡣ㸪⬻ෆỈศ㔞ࡀቑຍࡍࡿࡇࡼࡾᘬࡁ㉳ࡇࡉࢀࡿ⪃ᐹࡉ ࢀ࡚࠾ࡾ࠙ࠚ 㸪&3= ࡣᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࢆᘬࡁ㉳ࡇࡍࡇࡼࡗ࡚ ᾏ⥥≧ኚࢆㄏⓎࡍࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ࠙㸪㸪㸪ࠚࠋ&13DVH Ⓨ⌧ࡢ⤒ ⓗኚࡢ㐪࠸ࡣ㸪+&3 ཬࡧ &3= ᢞࣛࢵࢺ࠾ࡅࡿᾏ⥥≧ኚࡢ࣓࢝ࢽࢬ࣒ ࡀ␗࡞ࡿࡇ㉳ᅉࡍࡿࡶࡢ⪃࠼ࡿࠋࡋࡋ࡞ࡀࡽ㸪+&3 ཬࡧ &3= ᢞࣛࢵ ࢺࡢ⬨㧊࠾ࡅࡿ &13DVH Ⓨ⌧ࡢ⤒ⓗኚࡘ࠸࡚ࡣ᳨ウࢆᐇࡋ࡚࠸࡞ ࡗࡓࠋ+&3 ᢞࣛࢵࢺࡢ⬨㧊ⓑ㉁࡛ࡣ㸪ᕼ✺㉳⭺⣽⬊ࡢኚᛶཬࡧᾏ⥥≧ኚࡣ ㄆࡵࡽࢀࡓࡀ㸪⬻ࡢኚẚ㸪ࡑࡢ⛬ᗘࡣᙅࡗࡓࠋ⬨㧊ࡢኚࡣࢽࣜ ࣥᢞࣛࢵࢺ࠾࠸࡚ࡶㄆࡵࡽࢀࡓࡀ㸪ࢽ࡛ࣜࣥࡣ⬻ࡼࡾ⬨㧊ࡢኚ࠺ ࡀ⛬ᗘࡣᙉࡃ㸪&13DVH Ⓨ⌧ࡢቑᙉࡶㄆࡵࡽࢀ࡚࠸ࡿࠋࡲࡓ㸪&3= ᢞࣛࢵࢺࡢ ⬨㧊࡛ࡣᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡣㄆࡵࡽࢀࡓࡀ㸪ᾏ⥥≧ኚࡣㄆࡵࡽࢀ ࡞ࡗࡓࠋࡑࡇ࡛ᮏ❶࡛ࡣ㸪ኚࡢ⛬ᗘࡀᙅࡗࡓ⬨㧊࠾ࡅࡿ &13DVH Ⓨ⌧ࡢ ⤒ⓗኚࢆ᫂ࡽࡍࡿࡓࡵ㸪⬨㧊࠾ࡅࡿ⌮⤌⧊Ꮫⓗኚཬࡧ &13DVH Ⓨ ⌧ࡢ⤒ⓗኚࡘ࠸᳨࡚ウࡋࡓࠋ. .
(38) ᮦᩱ᪉ἲ ື≀ ᪥㱋ࡢ &UOM :, :LVWDU
(39) ࣛࢵࢺ㸦᪥ᮏࢳ࣮ࣕࣝࢫࣜࣂ࣮㸧 㸪㞤 ༉ཬࡧ ᪥㱋ࡢ &UO &'
(40) 6' ࣛࢵࢺ㸦᪥ᮏࢳ࣮ࣕࣝࢫࣜࣂ࣮㸧 㸪㞝 ༉ࢆᐇ㦂⏝࠸ࡓࠋ ᚤ⏕≀ࣞ࣋ࣝࡣ 63) ࡛࠶ࡗࡓࠋࣛࢵࢺࡣ㸪 ᗘ s Υ㸪‵ᗘ s 㸣㸪 Ẽ ᅇ㸭㛫㸪↷᫂㛫 㛫㸭᪥⥔ᣢࡉࢀࡓື≀ᐊ࠾࠸࡚㸪࣏ࣜ࢝ ࣮࣎ࢿ࣮ࢺࢣ࣮ࢪ࡚㣫⫱ࡋ㸪 ȣP ࣇࣝࢱ࣮ℐ㐣ᚋ⣸እ⥺↷ᑕࡋࡓỈ㐨Ỉ ᨺᑕ⥺⁛⳦῭ࡳࡢᐇ㦂ື≀⏝ᅛᙧ㣫ᩱ 0) ࠶ࡿ࠸ࡣᐇ㦂ື≀⏝⢊ᮎ㣫ᩱ &) 㸦࢚࢜ࣜࣥࢱࣝ㓝ẕ㸧ࢆ⮬⏤ᦤྲྀࡉࡏࡓࠋ ྜ≀ +&3㸦&+&O2㸪&$6 ␒ྕ ̽㸧࠾ࡼࡧ &3=㸦&+12㸪&$6 ␒ྕ ̽㸧ࡣ㸪6LJPD$OGULFK ♫㸦ᮾி㸪᪥ᮏ㸧ࡽධᡭࡋࡓࠋ+&3 ࡣ 㸣࢝ࣝ࣎࢟ ࢩ࣓ࢳࣝࢭ࣮ࣝࣟࢫ1D㸦&0&1D㸧୰ࡢ PJPO ࡞ࡿࡼ࠺ㄪᩚࡋࡓࠋ&3= ࢆᐇ㦂ື≀⏝⢊ᮎ㣫ᩱ㸦&)ࠊ࢚࢜ࣜࣥࢱࣝ㓝ẕ㸧ΰྜࡋ࡚㸪ZZ㸣ࡢᆒ୍ ࡞ΰྜ≀ࢆㄪ〇ࡋࡓࠋ ᐇ㦂ࣉࣟࢺࢥ࣮ࣝ +&3 ᢞཬࡧ &3= ᢞᐇ㦂㸸➨ ❶ྠᵝࡢࣉࣟࢺࢥ࣮࡛ࣝ㸪ື≀ࡣ㸪࣌ࣥ ࢺࣂࣝࣅࢱ࣮ࣝࢼࢺ࣒ࣜ࢘㸦ࢿࣥࣈࢱ࣮ࣝὀᑕ㸪᪥ᮏఫ〇⸆ᰴᘧ♫㸧ࡢ ⭡⭍ෆὀᑕࡼࡿ㯞㓉ୗ࠾࠸࡚㸪ᏳᴦṚࡉࡏࡓࠋ .
(41) ⤌⧊Ꮫⓗ᳨ᰝ +&3 ཬࡧ &3= ᢞᐇ㦂ࡶ㸪➨ ❶࡛᥇ྲྀࡋࡓ⮚ჾࡢ࠺ࡕ㸪㸣୰ᛶ⦆⾪ ࣐࡛࣍ࣝࣜࣥᅛᐃࡋࡓ⬨㧊ࡘ࠸࡚㸪ᐃἲᚑࡗ࡚㸪ᶓ᩿㠃ࡘ࠸࡚㸪ࣃࣛࣇ ࣥໟᇙࡋ࡚ษ∦ࢆస〇ࡋࡓࠋษ∦ࡣ +(ᰁⰍࢆࡋ࡚⤌⧊Ꮫⓗほᐹࡋࡓࠋ ࡲࡓ㸪୍ḟᢠయࡋ࡚ࣄࢺ &13DVH㸦 &KHPLFRQ,QWHUQDWLRQDO,QF7HPHFXOD &$ 86$㸧ࢆ⏝࠸ࡓචᰁⰍࢆᐇࡋࡓࠋᢠཎ㈿ά㛵ࡋ࡚ࡣ㸪ࢫࣛࢻࢆ 㸣࣒ࣀࢭ࣮ࣂ࣮㸦᪥Ύ (0 ♫㸪ᮾி㸪᪥ᮏ㸧⛣ࡋ㸪:0: ࣉࣟࢭࢵ ࢧ࣮㸦0,㸪ᮾᒇ㸪ᮾி㸪᪥ᮏ㸧࡛ Υࠊ ศ㛫ࠊ࣐ࢡ࢙࣮ࣟ࢘ࣈฎ⌮ࢆ ࡋࡓࠋ ࠋ ᾏ⥥≧ኚཬࡧᕼ✺㉳⭺⣽⬊ࡢኚᛶ㸦+&3 ᢞࣛࢵࢺ࡛ࡣ᰾⃰⦰㸪&3= ᢞ ࣛࢵࢺ࡛ࡣ⃰⦰ࡋࡓዲ㓟ᛶࡢ⣽⬊㉁ࢆక࠺᰾ࡢ᩿∦㸧ࡢ⛬ᗘ㸪&13DVH චᰁ Ⰽࡢ⛬ᗘࢆ ࡘ㸦㹼㸧ࢢ࣮ࣞࢹࣥࢢࡋࡓࠋᾏ⥥≧ኚࡢሙྜ㸪㸸ኚ࡞ ࡋ㸪㸸ⓑ㉁ᑠᆺࡢ✵⬊ࡀᩓᅾ㸪㸸ⓑ㉁ᑠᆺࡽ୰ᆺࡢ✵⬊ࡀࡧࡲࢇᛶ ㄆࡵࡽࢀࡿࠋᕼ✺㉳⭺⣽⬊ࡢኚᛶࡢሙྜ㸪㸸ኚ࡞ࡋ㸪㸸㍍ᚤ࡞ኚᛶ㸪㸸 ㍍ᗘ࡞ኚᛶࠋ&13DVH චᰁⰍࡢሙྜ㸪㸸ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ࢆ⦕ྲྀࡿࡼ࠺ ㍍ᗘࡢ㝧ᛶᛂࡀほᐹࡉࢀࡿࠋ࠸ࡎࢀࡢホ౯ࡶࢫࢥࡢᖹᆒ್ࢆ⟬ฟࡋࡓࠋ ࡇࡢᐇ㦂ࡣࠕື≀ᐇ㦂㛵ࡍࡿᣦ㔪㸦ᰴᘧ♫㹊㹑㹇࣓ࢹ࢚ࣥࢫ ⸆ᨭ ᴗᮏ㒊 ヨ㦂◊✲ࢭࣥࢱ࣮㸧 ࠖᇶ࡙ࡁ㸪㮵ᓥ◊✲ᡤື≀ᐇ㦂ጤဨࡢᢎㄆ ࢆᚓ࡚ᐇࡋࡓࠋ. .
(42) ⤖ᯝ ⌮⤌⧊Ꮫⓗ᳨ᰝࡢᾏ⥥≧ኚ㸪ᕼ✺㉳⭺⣽⬊ࡢኚᛶ࣭࣏ࢺ࣮ࢩࢫཬࡧ &13DVH චᰁⰍࡢ⛬ᗘࢆ 7DEOH ཬࡧ ࡲࡵࡓࠋ +&3 ᢞࣛࢵࢺ࡛ࡣ㸪 ᪥ࡽ ᪥㸦ᅇ ᪥㸧┠ࡅ࡚⬨㧊ⓑ㉁ࡢᾏ⥥ ≧ኚࡀほᐹࡉࢀࡓࠋ ᪥┠࡛ࡣ⬨㧊⫼ഃ᮰ᾏ⥥≧ኚࡀㄆࡵࡽࢀࡓࡀ㸪 ᪥ ┠࡛ࡣⓑ㉁యᣑࡀࡗ࡚࠸ࡓࠋࡲࡓ㸪 ᪥┠࡛ࡣ㸪✵⬊ࡢࡁࡉᐦᗘࡣ㧗ࡃ ࡞ࡾ㸪ⓑ㉁ᑠᆺࡽ୰ᆺࡢ✵⬊ࡀࡧࡲࢇᛶㄆࡵࡽࢀࡓ㸦ᅗ 㸧ࠋࡲࡓ㸪 ᪥ ┠ࡽ ᪥┠࡛ࡣ㸪᰾⃰⦰ࢆక࠺ᕼ✺㉳⭺⣽⬊ࡢኚᛶࡀᾏ⥥≧ኚࢆ♧ࡍ⬨㧊 ⓑ㉁ࡶㄆࡵࡽࢀࡓ㸦ᅗ LQVHW㸧 ࠋ᰾ࡣṇᖖࡼࡾᑠᆺ࡞ࡾ㸪⃰ࡃ㸪ࢡ࣐ࣟࢳࣥ ࡣᆒ୍࡛࠶ࡗࡓࠋ⬨㧊࠾ࡅࡿࡇࢀࡽኚࡢ⤒ⓗ࡞ኚࡣ㸪⬻㸪ᑠ⬻ࡸᘏ 㧊࡛ㄆࡵࡽࢀࡓኚྠᵝ࡛࠶ࡗࡓࠋࡋࡋ࡞ࡀࡽ㸪⬨㧊ࡢኚࡣ㸪⬻㸪ᑠ ⬻ཬࡧᘏ㧊ࡢኚẚ㸪㍍ᗘ࡛࠶ࡗࡓࠋ &3= ᢞࣛࢵࢺ࡛ࡣ㸪࠸ࡎࢀࡢ᳨⣴࣏ࣥࢺ࠾࠸࡚ࡶᾏ⥥≧ኚࡣㄆࡵࡽ ࢀ࡞ࡗࡓ㸦ᅗ 㸧 ࠋ ᪥┠ࡽ ᪥㸦ᅇ ᪥㸧┠㸪⬨㧊ࡢⓑ㉁㸦ᅗ LQVHW $㸧ཬࡧ⅊ⓑ㉁㸦ᅗ LQVHW %㸧࠾࠸࡚㸪ᕼ✺㉳⭺⣽⬊ࡢ᰾ࡀ᩿∦ࡋ㸪⣽⬊ ㉁ࡀዲ㓟ᛶࢆ♧ࡍ࣏ࢺ࣮ࢩࢫീࡀㄆࡵࡽࢀࡓࠋ &13DVH චᰁⰍ࠾࠸࡚㸪ṇᖖࡢᕼ✺㉳⭺⣽⬊࡛ࡣ &13DVH 㝧ᛶᛂࡀ⣽⬊ ⭷ࢆ⦕ྲྀࡿࡼ࠺ㄆࡵࡽࢀࡓ㸦ᅗ $㸧ࠋ+&3 ᢞࣛࢵࢺ࡛ࡣ㸪 ᪥┠ࡽ ᪥ ┠ࡲ࡛㸪&13DVH 㝧ᛶീࡣ⬨㧊⅊ⓑ㉁ࡢᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ࢆ⦕ྲྀࡿࡼ࠺ㄆ ࡵࡽࢀ㸪ᑐ↷⩌ࡢᕪࡣㄆࡵࡽࢀ࡞ࡗࡓ㸦ᅗ %㸧ࠋࡲࡓ㸪 ᪥㸦ᅇ ᪥㸧 ┠࠾࠸࡚ࡶ㸪ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ࢆ⦕ྲྀࡿࡼ࠺ &13DVH 㝧ᛶീࡀㄆࡵࡽࢀ㸪 ᑐ↷⩌ࡢᕪࡣㄆࡵࡽࢀ࡞ࡗࡓ㸦ᅗ &㸧ࠋ&3= ᢞࣛࢵࢺ࠾࠸࡚ࡶ㸪 ᪥ ┠ࡽ ᪥┠ࡲ࡛㸪&13DVH 㝧ᛶᛂࡣ㸪⬨㧊⅊ⓑ㉁ࡢᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ࢆ .
(43) ⦕ྲྀࡿࡼ࠺ㄆࡵࡽࢀ㸪ᑐ↷⩌ࡢᕪࡣㄆࡵࡽࢀ࡞ࡗࡓ㸦ᅗ ' DQG (㸧ࠋ ᪥㸦ᅇ ᪥㸧┠㸦ᅗ )㸧ࢆྵࡵ㸪࠸ࡎࢀࡢ᳨⣴࣏ࣥࢺ࠾࠸࡚ࡶ㸪&13DVH 㝧ᛶീࡢቑᙉࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ. .
(44) ⪃ᐹ +&3 ཬࡧ &3= ᢞࣛࢵࢺࡢ⬨㧊࠾ࡅࡿ⌮⤌⧊Ꮫⓗ᳨ᰝཬࡧචᰁⰍ࠾ ࠸࡚㸪㧊㠧ཬࡧᕼ✺㉳⭺⣽⬊ࡢኚࡢ⛬ᗘࡣ㸪⬻㸪≉⬻㸪ᑠ⬻ࡸᘏ㧊ࡢ ኚࡢ⛬ᗘࡣ␗࡞ࡿࡇࡀ♧ࡉࢀࡓࠋࡲࡓ㸪&13DVH Ⓨ⌧ࡣ㸪+&3 ཬࡧ &3= ᢞ ᚋࡢ⬨㧊⅊ⓑ㉁࡛ࡣቑᙉࡉࢀ࡞࠸ࡇࡀ♧ࡉࢀࡓࠋ +&3 ᢞࣛࢵࢺ࡛ࡣ㸪⬻㸪ᑠ⬻ཬࡧᘏ㧊㢧ⴭ࡞ᾏ⥥≧ኚࡀㄆࡵࡽࢀࡓ ࡀ㸪⬨㧊ⓑ㉁࡛ࡣ㍍ᚤ㸪࠶ࡿ࠸ࡣ㍍ᗘ࡞ኚࡋㄆࡵࡽࢀ࡞ࡗࡓࠋࡲࡓ㸪 ⬻࡛ࡣ㸪&13DVH Ⓨ⌧ࡣᕼ✺㉳⭺⣽⬊ཬࡧ㧊㠧ࡢയᐖᚋࡢᅇ㐣⛬ቑᙉࡀㄆ ࡵࡽࢀࡓࠋࡋࡋ࡞ࡀࡽ㸪⬨㧊࡛ࡣ &13DVH Ⓨ⌧ࡢቑᙉࡣ㸪ᅇ㐣⛬࠾࠸࡚ࡶ ㄆࡵࡽࢀ࡞ࡗࡓࠋ➨ ❶࡛⏝࠸ࡓࢽ࡛ࣜࣥࡣ㸪+&3 ྠᵝ⬨㧊ⓑ㉁ᾏ ⥥≧ኚࡀㄆࡵࡽࢀࡓࡀ㸪ࢽ࡛ࣜࣥࡣ⬻ࡼࡾ⬨㧊ࡢ࠺ࡀ⛬ᗘࡣᙉࡗࡓࠋ ࡲࡓ㸪ࢽࣜࣥࡣ &13DVH ࡢⓎ⌧ቑᙉࡶㄆࡵࡽࢀࡓࡇࡽ㸪ྠࡌ㒊࡛࠶ࡗ࡚ ࡶኚࡢ⛬ᗘࡼࡗ࡚㸪&13DVH ࡢⓎ⌧ࡀ␗࡞ࡿࡇࡀ♧၀ࡉࢀࡓࠋ &3= ᢞࣛࢵࢺࡢ⬨㧊࡛ࡣ㸪ᾏ⥥≧ኚࡣㄆࡵࡽࢀ࡞ࡗࡓࡶࡢࡢ㸪ᕼ✺㉳ ⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡣㄆࡵࡽࢀࡓࠋᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡣ㸪&3= ⬺ 㧊ࣔࢹ࡛ࣝࡣ⬺㧊๓ㄆࡵࡽࢀࡿࡇࡀሗ࿌ࡉࢀ࡚࠾ࡾ࠙ࠚ㸪⬨㧊⬺㧊ࡀ㉳ ࡁࡿࡇࡣሗ࿌ࡉࢀ࡚࠸࡞࠸࠙㸪ࠚࠋࡋࡓࡀࡗ࡚㸪ᮏ◊✲ࡢ⤖ᯝࡣ㸪ࡇࢀࡽ ࡢሗ࿌୍⮴ࡋ࡚࠸ࡓࠋࡲࡓ㸪&13DVH ࡢⓎ⌧ቑᙉࡣ㸪࠸ࡎࢀࡢ᳨⣴࣏ࣥࢺ ࠾࠸࡚ࡶㄆࡵࡽࢀ࡞ࡗࡓࡇࡽ㸪ᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡣ㸪&13DVH ࡢⓎ⌧ቑᙉ㛵ࡋ࡚࠸࡞࠸ࡇࡀ♧၀ࡉࢀࡓࠋࡲࡓ㸪⬻㸪ᑠ⬻ཬࡧᘏ㧊 ࠾ࡅࡿᾏ⥥≧ኚࡣ㸪 ᪥┠ࡽㄆࡵࡽࢀ㸪&13DVH ࡢⓎ⌧ቑᙉࡶࡇࢀࡽࡢኚ ࡢ㐍⾜కࡗ࡚ㄆࡵࡽࢀࡓࠋࡋࡓࡀࡗ࡚㸪&13DVH ࡢⓎ⌧ቑᙉࡣ㧊㠧ࡢയᐖࡼ ࡗ࡚㉳ࡁࡿࡶࡢ⪃࠼ࡽࢀࡿࠋ$FV ࡽࡣ㸪㖡㛵㐃㓝⣲㸪&X=Q62' ࡢࡼ࠺࡞㖡. .
(45) ྵ᭷⿵ḞศᏊ᪘ཬࡧ྾㙐⺮ⓑ㉁ &RPSOH[,9 ࡣ㸪&3= ⬺㧊ࣔࢹ࣐ࣝ࢘ࢫ࠾࠸ ࡚㸪⬺㧊ࡀㄆࡵࡽࢀࡿ⬻ᱱཬࡧṇᖖ⬨㧊ࡢ୧᪉࡛ῶᑡࡍࡿࡇࢆሗ࿌ࡋࡓ࠙ࠚ ࠋ ࡇࡢ⤖ᯝࡣ㸪୰ᯡ⚄⤒⣔࠾࠸࡚㸪&3= ᑐࡍࡿᕼ✺㉳⭺⣽⬊ࡢ㑅ᢥⓗ⬤ᙅᛶ ࡀ࠶ࡿࡇࢆ♧၀ࡋ࡚࠾ࡾ㸪┦స⏝ࡍࡿ⣽⬊ෆศᏊࡢⓎ⌧ࡀ␗࡞ࡿࡇ㸪ᕼ ✺㉳⭺⣽⬊๓㥑⣽⬊ࡢ⏤᮶ࡀ␗࡞ࡿࡇ࠙ 㸪ࠚ 㸪ࡲࡓࡣ⣽⬊ᚤᑠ⎔ቃࡢ㐪࠸ ࡀ㑅ᢥⓗ⬤ᙅᛶ㛵㐃ࡋ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿ࠙ࠚࠋᮏ◊✲࠾࠸࡚ࡶ㸪 &3= ᢞࣛࢵࢺࡢ୰ᯡ⚄⤒⣔࠾ࡅࡿᾏ⥥≧ኚࡢศᕸ㐪࠸ࡀぢࡽࢀࡓࠋࡇ ࢀࡣ㸪$FV ࡽࡼࡗ࡚♧၀ࡉࢀࡓᕼ✺㉳⭺⣽⬊๓㥑⣽⬊ࡲࡓࡣᚤᑠ⎔ቃࡢ㐪࠸ࢆ ᫎࡋ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋ +&3 ཬࡧ &3= ᢞࣛࢵࢺࡢ⬨㧊࡛ࡣ㸪⬻㸪ᑠ⬻ཬࡧᘏ㧊ẚ㍑ࡋ࡚㸪ኚ ࡢ⛬ᗘཬࡧ &13DVH Ⓨ⌧ࡀ␗࡞ࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡲࡓ㸪➨ ❶࡛⏝࠸ࡓ ࢽ࡛ࣜࣥࡣ⬨㧊࠾࠸࡚ᾏ⥥≧ኚཬࡧ &13DVH ࡢⓎ⌧ቑᙉࡀㄆࡵࡽࢀࡓࡇ ࡽ㸪ྠࡌ㒊࡛࠶ࡗ࡚ࡶኚࡢ⛬ᗘࡼࡗ࡚㸪&13DVH ࡢⓎ⌧ࡀ␗࡞ࡿࡇ ࡀ♧၀ࡉࢀࡓࠋ+&3 ཬࡧ &3= ᢞࡼࡿᾏ⥥≧ኚࡢㄏⓎ࣓࢝ࢽࢬ࣒ࡣྛࠎ␗ ࡞ࡿࡀ㸪&13DVH ࡢⓎ⌧ቑᙉࡣ +&3 ཬࡧ &3= ᢞࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿ㧊㠧ࡢ ᦆയࡢ⛬ᗘ౫Ꮡࡍࡿࡇࡀ♧၀ࡉࢀࡓࠋ. .
(46) ᑠᣓ +&3 ཬࡧ &3= ᢞࣛࢵࢺࡢ⬨㧊ࡢ᳨⣴ࡽ㸪㧊㠧ཬࡧᕼ✺㉳⭺⣽⬊ࡢኚࡢ ⛬ᗘࡣ㸪⬻㸪ᑠ⬻ࡸᘏ㧊ࡣ␗࡞ࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡲࡓ㸪&13DVH Ⓨ ⌧ࡣ㸪+&3 ཬࡧ &3= ᢞᚋࡢ⬨㧊⅊ⓑ㉁࡛ࡣቑᙉࡉࢀ࡞࠸ࡇࡶ᫂ࡽ࡞ࡗ ࡓࠋࡲࡓ㸪➨ ❶࡛⏝࠸ࡓࢽ࡛ࣜࣥࡣ⬨㧊࠾࠸࡚ᾏ⥥≧ኚཬࡧ &13DVH ࡢ Ⓨ⌧ቑᙉࡀㄆࡵࡽࢀࡓࡇࡽ㸪ྠࡌ㒊࡛࠶ࡗ࡚ࡶኚࡢ⛬ᗘࡼࡗ࡚㸪 &13DVH ࡢⓎ⌧ࡀ␗࡞ࡿࡇࡀ♧၀ࡉࢀࡓࠋࡍ࡞ࢃࡕ㸪+&3 ཬࡧ &3= ᢞࡼ ࡿᾏ⥥≧ኚࡢㄏⓎ࣓࢝ࢽࢬ࣒ࡣྛࠎ␗࡞ࡿࡀ㸪&13DVH ࡢⓎ⌧ቑᙉࡣ +&3 ཬࡧ &3= ᢞࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿ㧊㠧ࡢᦆയࡢ⛬ᗘ౫Ꮡࡍࡿࡇࡀ♧၀ࡉࢀࡓࠋ &3= ᢞࣛࢵࢺ࡛ࡣ㸪⬨㧊ⓑ㉁ᾏ⥥≧ኚࡣㄆࡵࡽࢀ࡞ࡗࡓࡀ㸪ᕼ✺㉳ ⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡣㄆࡵࡽࢀࡓࠋ㐣ཤࡢሗ࿌࡛ࡣ㸪&3= ⬺㧊ࣔࢹࣝ࠾࠸ ࡚ᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡀ⬺㧊๓ㄆࡵࡽࢀ࡚࠾ࡾ㸪ࡉࡽ⬨㧊࡛⬺㧊 ࡣ㉳ࡁ࡚࠸࡞࠸㸬ࡲࡓ㸪&3= ᑐࡍࡿᕼ✺㉳⭺⣽⬊ࡢ㑅ᢥⓗ⬤ᙅᛶࡀ࠶ࡿࡇ ࢆ♧၀ࡍࡿሗ࿌ࡶ࠶ࡾ㸪୰ᯡ⚄⤒⣔ෆࡢᾏ⥥≧ኚࡢศᕸ㐪࠸ࡣ㸪&3= ᑐ ࡍࡿᕼ✺㉳⭺⣽⬊ࡢ㑅ᢥ⬤ᙅᛶࡢ㐪࠸ࢆᫎࡋ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋ. .
(47) ⥲ᣓ ୰ᯡ⚄⤒⣔ᾏ⥥≧ኚࢆㄏⓎࡍࡿྜ≀㸪ࢽࣜࣥ㸪+&3 ཬࡧ &3= ࢆᗂⱝ ࣛࢵࢺᢞࡋ㸪ኚࢆㄏⓎࡋࡓࠋᾏ⥥≧ኚࡣ㉸ᚤᙧែᏛⓗ㧊㠧ࡢゎ㞳࡛ ࠶ࡿࡇࡽ㸪ᾏ⥥≧ኚㄏⓎࡢ㧊㠧㛵㐃㓝⣲ࡸ⺮ⓑ㸪ࡍ࡞ࢃࡕ㸪&13DVH㸪 0%3㸪3/3 ཬࡧ *DO ࡀࡢࡼ࠺࡞ᣲືࢆ♧ࡍࡢࢆ⌮⤌⧊Ꮫⓗㄪࡓࡇ ࢁ㸪&13DVH ኚࡀㄆࡵࡽࢀࡓࠋࡇࡢࡓࡵ㸪㍈⣴࿘ᅖ㡿ᇦᮍ⇍ࡽᡂ⇍ᕼ✺ ㉳⭺⣽⬊ࡢ⣽⬊⭷ୖᏑᅾࡍࡿᕼ✺㉳⭺⣽⬊ࡢศ࣐࣮࣮࢝ࡢ୍ࡘ࡛࠶ࡿ &13DVH࠙ࠚ╔┠ࡋ㸪ኚㄏⓎ࠾ࡅࡿ &13DVH Ⓨ⌧ࡢ⤒ⓗኚࡘ࠸ ᳨࡚ウࡋࡓࠋᾏ⥥≧ኚࡘ࠸࡚ࡣ㸪ࢽ࡛ࣜࣥࡣᶫ㸪ᘏ㧊ཬࡧ⬨㧊ⓑ㉁࡛ㄆ ࡵࡽࢀ㸪≉⬨㧊ⓑ㉁࡛㢧ⴭ࡛࠶ࡗࡓࠋ+&3 ࡛ࡣ࣭ᑠ⬻㸪ᘏ㧊ཬࡧ⬨㧊ⓑ㉁ ࡛ㄆࡵࡽࢀ㸪࣭ᑠ⬻ཬࡧᘏ㧊࡛㢧ⴭ࡛࠶ࡗࡓࠋ&3= ࡛ࡣ⬻ཬࡧᑠ⬻ࡢⓑ㉁㸪 ୪ࡧ⬻⓶㉁ᾏ⥥≧ኚࡀㄆࡵࡽࢀࡓࡀ㸪⬨㧊࡛ࡣኚࡣㄆࡵࡽࢀ࡞ࡗ ࡓࠋࡇࢀࡽࡢྜ≀ᢞࡼࡗ࡚ㄏⓎࡉࢀࡓᾏ⥥≧ኚࡣ㸪࠸ࡎࢀࡶ㉸ᚤᙧែᏛ ⓗࡣ㧊㠧ࡢゎ㞳࡛࠶ࡗࡓࠋ&13DVH Ⓨ⌧ࡘ࠸࡚ࡣ㸪ࢽ࡛ࣜࣥࡣᾏ⥥≧ኚ ࡀㄆࡵࡽࢀࡿ๓Ⓨ⌧ࡢࣆ࣮ࢡ㐩ࡋ࡚࠸ࡿࡇࡀุ᫂ࡋࡓࠋ㉸ᚤᙧែᏛⓗ ࡣᢞᚋ᪩ᮇ㧊㠧ࡢゎ㞳ࡀㄆࡵࡽࢀࡓࡇࡽ㸪യᐖࡢ᪩ᮇࡽ &13DVH ࡢⓎ ⌧ࡀㄏⓎࡉࢀ㸪യᐖࡢ㐍⾜కࡗ࡚ &13DVH ࡢⓎ⌧ࡀῶᙅࡍࡿࡇࡀศࡗࡓࠋ +&3 ࡛ࡣᾏ⥥≧ኚࡀㄆࡵࡽࢀࡓᢞᮇ㛫୰ࡣⓎ⌧ࡢቑᙉࡣㄆࡵࡽࢀࡎ㸪ᅇ ᮇ㛫୰㸪ࡍ࡞ࢃࡕ㸪ᾏ⥥≧ኚࡢ⛬ᗘࡀῶᙅࡋࡓⅬ࡛Ⓨ⌧ࡢࣆ࣮ࢡࡀㄆࡵ ࡽࢀࡓࠋ&3= ࡛ࡣᾏ⥥≧ኚࡀㄆࡵࡽࢀࡓᢞᮇ㛫୰Ⓨ⌧ࡢࣆ࣮ࢡࡀㄆࡵࡽ ࢀࡓࠋ+&3 ཬࡧ &3= ᢞ࠾ࡅࡿ &13DVH Ⓨ⌧ࡢ⤒ⓗኚࡢ㐪࠸ࡣ㸪ᾏ⥥≧ ኚࡢ࣓࢝ࢽࢬ࣒ࡀ␗࡞ࡿࡇ㉳ᅉࡋ࡚࠸ࡿࡶࡢ⪃࠼ࡿࠋࡍ࡞ࢃࡕ㸪+&3 ࡣ⬻ෆỈศ㔞ࢆቑຍࡉࡏࡿࡓࡵ㸪ቑຍࡋࡓỈศࡀ㧊㠧㛫ධࡾ㎸ࡴࡇࡼࡗ. .
(48) ࡚ᾏ⥥≧ኚࢆᘬࡁ㉳ࡇࡍ࠙ࠚࠋ&3= ࡣᕼ✺㉳⭺⣽⬊ࡢ࣏ࢺ࣮ࢩࢫࡼࡾᾏ ⥥≧ኚࢆᘬࡁ㉳ࡇࡍ࠙㸪㸪㸪ࠚ ࠋࡋࡓࡀࡗ࡚㸪&13DVH Ⓨ⌧ࡢ⤒ⓗኚ ࡢ㐪࠸ࡣ㸪ࡇࢀࡽ࣓࢝ࢽࢬ࣒ࡢ㐪࠸㉳ᅉࡋ࡚࠸ࡿࡶࡢ⪃࠼ࡿࠋࡲࡓ㸪ࢽ ࣜࣥࡣ࣑ࢺࢥࣥࢻࣜࡢ㓟ⓗࣜࣥ㓟ࢆ⬺ඹᙺࡋ㸪ᕼ✺㉳⭺⣽⬊ࡢᶵ⬟㞀ᐖ ࢆᘬࡁ㉳ࡇࡍ࠙ 㸪㸪ࠚࡇࡼࡗ࡚㸪ᾏ⥥≧ኚࢆᘬࡁ㉳ࡇࡍࠋྛྜ ≀࠾ࡅࡿᾏ⥥≧ኚࡢ࣓࢝ࢽࢬ࣒ࡀ␗࡞ࡿࡇࡀ㸪&13DVH Ⓨ⌧ࡢ⤒ⓗኚ ࡢ㐪࠸㉳ᅉࡋ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋࡲࡓ㸪+&3 ཬࡧ &3= ࡢ⬨㧊ࡢ᳨ウ ࡽ㸪+&3 ࡛ࡣࡢ㡿ᇦẚ㸪⬨㧊ⓑ㉁ࡢᾏ⥥≧ኚࡀ㍍ᗘ࡛࠶ࡗࡓࠋࡲࡓ㸪 &3= ࡢ⬨㧊࡛ࡣᾏ⥥≧ኚࡣㄆࡵࡽࢀࡎ㸪&13DVH Ⓨ⌧ࡣ㸪+&3 ཬࡧ &3=㸪࠸ࡎ ࢀࡶ⬨㧊⅊ⓑ㉁࡛ࡣቑᙉࡉࢀ࡞ࡗࡓࠋࡇࢀࡽࡢࡇࡽ㸪+&3 ཬࡧ &3= ࡢᾏ ⥥≧ኚࡢㄏⓎ࣓࢝ࢽࢬ࣒ࡣྛࠎ␗࡞ࡿࡀ㸪&13DVH ࡢⓎ⌧ࡣ +&3 ཬࡧ &3= ᢞ ࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿኚࡢ⛬ᗘ౫Ꮡࡍࡿࡇࡀ♧၀ࡉࢀࡓࠋ &13DVH ࡣ㸪ᮍ⇍ࡽᡂ⇍ᕼ✺㉳⭺⣽⬊ࡢ⣽⬊⭷ୖᏑᅾࡍࡿศ࣐࣮࣮࢝ࡢ ୍ࡘ࡛࠶ࡾ㸪㧊㠧ࡢ㍈⣴࿘ᅖ㡿ᇦࡶศᕸࡋ࡚࠸ࡿ࠙ࠚࠋࡲࡓ㸪&13DVH ࡣ㸪 㧊㠧ᙧᡂࡸᕼ✺㉳⭺⣽⬊ࡢ⣽⬊㉁ࡢఙ㛗㛵ࡋ࡚࠸ࡿࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ ࠙㸪ࠚࠋᅇࡢ᳨⣴ࡽ㧊㠧ࡢയᐖࡼࡗ࡚㸪&13DVH Ⓨ⌧ࡀቑᙉࡍࡿࡇ ࡀ᫂ࡽ࡞ࡗࡓࠋࡲࡓ㸪&13DVH Ⓨ⌧ࡢᮇࡣྛྜ≀ࡼࡾ␗࡞ࡿࡇࡀ᫂ ࡽ࡞ࡾ㸪ྛྜ≀࠾ࡅࡿᾏ⥥≧ኚࡢ࣓࢝ࢽࢬ࣒ࡀ␗࡞ࡿࡇ㉳ᅉࡋ ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋࡲࡓ㸪&13DVH Ⓨ⌧ࡣᾏ⥥≧ኚࡢയᐖࡢ⛬ᗘ౫ Ꮡࡍࡿࡇࡀ♧၀ࡉࢀࡓࠋ୰ᯡ⚄⤒⣔ࡢയᐖ࠾ࡅࡿ &13DVH ࡢᙺࢆ᫂ࡽ ࡍࡿࡣ㸪ࡉࡽ㧊㠧യᐖࢆㄏⓎࡍࡿྜ≀ࢆ⏝࠸࡚㸪&13DVH ࡢ⤒ⓗኚ ࡘ࠸࡚㸪ㄪᰝࢆ㏣ຍࡍࡿᚲせࡀ࠶ࡿ⪃࠼ࡿࠋ. .
(49) ㅰ㎡ ᮏ✏ࢆ⤊࠼ࡿ࠶ࡓࡾ㸪ᮏ◊✲ࡢ㐙⾜㝿ࡋ࡚⤊ጞᚚᣦᑟ㈷ࡾࡲࡋࡓᖏᗈ␆ ⏘Ꮫࢢ࣮ࣟࣂࣝࢢ࣓ࣟࢹࢩࣥ◊✲ࢭࣥࢱ࣮⋇་Ꮫ◊✲㒊㛛ᐙ␆⌮Ꮫ◊ ✲ᐊ ྂᯘᚿᏳ ᩍᤵ㸪ᰴᘧ♫㹊㹑㹇࣓ࢹ࢚ࣥࢫ⸆ᴗᮏ㒊㮵ᓥ◊✲ ᡤ⌮◊✲㒊 ᅵ㇂⛱ 㢳ၥ῝ㅰࡋࡲࡍࠋ ᮏ✏సᡂ㝿ࡋ㸪᭷┈࡞ᚚຓゝᚚᰯ㜀ࢆ㡬࠸ࡓᖏᗈ␆⏘Ꮫែ⌮Ꮫ◊ ✲ᐊ ྂᒸ⚽ᩥ ᩍᤵ㸪ᮾி㎰ᕤᏛ⋇་⌮Ꮫ◊✲ᐊ ㇂῟ ᩍᤵ㸪ᒾᡭ Ꮫẚ㍑⸆⌮ẘᛶᏛ◊✲ᐊ బ⸨ὒ ᩍᤵ㸪ᒱ㜧Ꮫ⋇་⌮Ꮫ◊✲ᐊ 㓇 ὒᶞ ᩍᤵ῝⏒࡞ࡿㅰពࢆ⾲ࡋࡲࡍࠋᰴᘧ♫㹊㹑㹇࣓ࢹ࢚ࣥࢫ⸆ᴗ ᮏ㒊㮵ᓥ◊✲ᡤ⌮◊✲㒊ࡢⓙᵝࡣ㸪ࡁࢀ࠸࡞ᶆᮏࢆస〇ࡋ࡚࠸ࡓࡔࡁࡲࡋ ࡓࡇ㸪࡞ࡽࡧ᭷┈࡞ᚚຓゝ࣭ᚚ㠴᧡ࢆ࠸ࡓࡔࡁࡲࡋࡓࢆឤㅰ࠸ࡓࡋࡲࡍࠋ . .
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