94_nenkai_endai

(1)

Human mesenchymal stem cells from adipose tissue and umbilical cord

improved neuropathic pain by regulating inflammation and recovery of the

demyelination of sciatic nerve in rats

Kanako Miyano

1,2

_{, Minori Ikehata}

3

_{, Kaori Ohshima}

2,4

_{, Yuki Yoshida}

5

_{, Yasuhiro Nose}

3

_,

Sei-ichi Yoshihara

3

_{, Katsuyuki Oki}

3

_{, Seiji Shiraishi}

6

_{, Miaki Uzu}

7

_{, Miki Nonaka}

2

_{, Yoshikazu Higami}

5

_,

Minoru Narita

1,8

_{, Yasuhito Uezono}

2

1_{Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst.,}2_{Dept. Pain & Cont. Res., The Jikei Univ. Sch. of Med.,}3_R&D

Dept. Biomimetics Sympathies Inc.,4_{Pathol., Immunol. and Microbiol., Grad. Sch. of Med., The Univ. of Tokyo.,} 5_{Lab. Mol. Pathol. and Metab. Disease, Faculty of Pharm. Sci., Tokyo Univ. of Sci.,}6_{Div. Cancer Pathophysiol.,}

Natl. Hosp. Org. Kure Med.,7_{Vitrigel Prj., Inst. of Agrobiol. Sci., NARO.,}8_{Dept. Pharmacol., Hoshi Univ. Sch. of}

Pharm. and Pharma. Sci.

(2)

KCNQ (Kv7) K

channel opener retigabine inhibits pain and itch.

Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe

Lab. of Pharmacol., Sch. of Pharmacy, Kitasato Univ.

(3)

Mechanisms of hyperalgesia in dry eye model rats: involvement of the glial

cells and the voltage-gated Ca

2+

channel α2δ subunit in the trigeminal

nucleus

Yuto Tei

1,2

_{, Yoshinori Mikami}

1

_{, Masanori Ito}

1

_{, Taichiro Tomida}

1

_{, Daisuke Ohshima}

1

_{, Yuichi Hori}

2

_,

Satomi Adachi-Akahane

1

1_{Department of Physiology, Faculty of Medicine, Toho University,}2_{Department of Ophthalmology, Faculty of}

Medicine, Toho University

(4)

TRPV1 and TRPA1 are cooperatively involved in the tooth movement-related

pain.

Kazunori Adachi

1

_{, Misato Yugawa}

2

1_{Div. Pharmacol. Meikai Univ. Schol. Dent.,}2_{Div. Orthodont. Meikai Univ. Schol. Dent.}

(5)

Implicated in spinal cholecystokinin-8 and hemokinin-1 in type 1 diabetes

allodynia in mice

Takafumi Hayashi

1

_{, Chizuko Watanabe}

2

_{, Syu-ichi Kanno}

3

_{, Masaru Yoshizumi}

2

_,

Yasuyuki Agatsuma

1

_{, Akiyoshi Hara}

3

_{, Shinobu Sakurada}

4

1_{Lab. Pharmaceut. Sci., Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ.,}2_{Dept. Physiol. Anato., Fac.}

Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ.,3_{Dept. Clin. Pharmacotherap., Fac. Pharmaceut. Sci., Tohoku}

Med. Pharmaceut. Univ.,4_{Tohoku Med. Pharmaceut. Univ.}

(6)

Two-way association between sleep disturbance and persistent pain

Yabe Shuhei

1

_{, Yusuke Hamada}

1,2

_{, Kenichi Tanaka}

1

_{, Yoshiyuki Yamabe}

1

_{, Michiko Narita}

2,3

_,

Naoko Kuzumaki

1

_{, Minoru Narita}

1,2

1_{Dept. Pharmacol., Hoshi Univ., Tokyo, Japan,}2_{Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan,} 3_{Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan}

(7)

Comparison of the effects of Goreisan and loxoprofen on cerebral blood

flow dynamics in meteoropathy model mice

Sumika Ryu

1

_{, Yuki Kurauchi}

1,2

_{, Risako Tanaka}

1

_{, Makito Haruta}

3

_{, Kiyotaka Sasagawa}

3

_,

Takahiro Seki

1,2

_{, Jun Ohta}

3

_{, Hiroshi Katsuki}

1,2

1_{Dept Chemico-Pharmacol Sci, Sch Pharm, Kumamoto Univ,}2_{Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci,}

Kumamoto Univ,3_{Division of Materials Science, Graduate School of Science and Technology, Nara Institute of}

Science and Technology

(8)

Itch and pain caused by intradermal injection of sulfides in mouse cheek:

Effect of genetic deletion of Ca

v

3.2 T-type calcium channels

Shotaro Kurahashi

1

_{, Iyo Nishiyama}

1

_{, Rina Minamino}

1

_{, Hiroyuki Nishikawa}

1,2

_{, Fumiko Sekiguchi}

1

_,

Maho Tsubota

1

, Atsufumi Kawabata

1

1_{Laboratory of Pharmacology & Pathophysiology, Faculty of Pharmacy, Kindai University,}2_{Fuso Pharmaceutical}

Industries, Ltd.

(9)

Phenotypic examination of the endocannabinoid-degrading enzyme

alpha/beta-hydrolase domain containing 6 (ABHD6) knockout rat

Katsuhiko Noguchi

1

_{, Kimio Sugaya}

1

_{, Saori Nishijima}

1

_{, Mayuko Sakanashi}

2

_{, Katsumi Kadekawa}

1

_,

Shiho Okitsu

3

_{, Sayomi Nakamine}

3

_{, Hidetsugu Torihara}

3

_{, Hideyuki Yamamoto}

3

1_{Southern Knights’ Laboratory Co., Ltd.,}2_{Dept. Pharmacy, Col. Pharmacy, Kinjo Gakuin University,}3_Dept.

Biochemistry, Grad. Sch. Med., Univ. the Ryukyus

(10)

MicroRNA expression profiling in ethanol dependence in mice

Keisuke Mizuo, Tomoka Yamaguchi, Satoshi Watanabe

Dept. of Legal Med. Sapporo Med. Univ. Sch. of Med.

(11)

Inhibitory effect of SB216763, a selective glycogen synthase kinase-3

inhibitor, on morphine-induced Straub’s tail reaction in mice

Junichi Kitanaka

1

_{, Nobue Kitanaka}

1

_{, Utau Horie}

1

_{, Yumi Kawasaki}

1

_{, Takashi Sakamoto}

1

_,

Junya Yashiro

1

_{, Koh-ichi Tanaka}

2

_{, Kento Igarashi}

2,3

_{, Kazuo Tomita}

2,3

_{, Ami Shiomoto}

4

_,

Kaname Watabe

4

_{, Kiyoshi Nakano}

4

_{, Hitoshi Takahashi}

4

_{, Nobuyoshi Nishiyama}

2

_{, Tomoaki Sato}

3

_,

Motohiko Takemura

1

1_{Dept. Pharmacol., Hyogo Col. Med.,}2_{Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci.,} 3_{Dept. Applied Pharmacol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ.,}4_{Muromachi Kikai, Co., Ltd.}

(12)

Analysis of the tendency of dependence for various targets based on the

psychological characteristic in undergraduate students

Ken-ichi Tanaka, Michiko Konno

Sch. Health Social Services, Saitama Pref. Univ.

(13)

Chronic pain-induced neuronal plasticity in the extended amygdala causes

maladaptive anxiety

Naoki Yamauchi, Hiroshi Nomura, Taiju Amano, Masabumi Minami

Dept Pharmacol Grad Sch Pharm Sci, Hokkaido Univ

(14)

Histological analyses of CRF mRNA expression in the dorsolateral bed

nucleus of the stria terminalis of chronic pain model rats

Saya Arakaki, Daiki Takahashi, Yuta Asaoka, Keisuke Kimura, Ryuto Hara, Keisuke Sakasai,

Hiroe Suzuki, Naoki Yamauchi, Hiroshi Nomura, Taiju Amano, Masabumi Minami

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University.

(15)

Development of a novel stress model using a video-recorded scene of the

social defeat stress in mice

Yuko Nakatake

1,2

_{, Hiroki Furuie}

2

_{, Masatoshi Ukezono}

3

_{, Misa Yamada}

2

_{, Kazumi Yoshizawa}

1

_,

Mitsuhiko Yamada

2

1_{Lab. Pharmacol. Therap., Grad. Sch. Pharmaceut. Sci., Tokyo Univ. Sci.,}2_{Dept. Neuropsychopharmacol., Natl.}

Inst. Mental Health, Natl. Center Neurol. Psychiat.,3_RIKEN

(16)

Social stress induces subcellular degeneration preceding dendritic loss of

prefrontal pyramidal neurons in mice

Chisato Numa

1

_{, Hirotaka Nagai}

1

_{, Midori Nagai}

1

_{, Nobuhiko Ohno}

2

_{, Yuko Mimori-Kiyosue}

3

_,

Yosky Kataoka

4

_{, Tomoyuki Furuyashiki}

1

1_{Dept. Med. Div. Pharmacol.,}2_{Jichi Med. Univ. Div. Hist. & Cell Biol. Dept. Anat.,}3_{RIKEN BDR Lab. Mol. & Cell.}

Dyn.,4_{RIKEN BDR Lab. Cell. Funct. Img.}

(17)

Left-right asymmetry in chronic stress-induced neuroinflammation

Kazutoshi Matsushita, Masayuki Taniguchi, Tomoyuki Furuyashiki

Div. Pharmacol., Grad. Sch. Med., Kobe Univ.

(18)

Role of Microsomal prostaglandin E synthase-1 in acute stress

Kawabata Yuta

1

_{, Asumi Doumae}

1

_{, Hiromi Hirata}

1

_{, Aki Sakahara}

1

_{, Satoshi Uematsu}

2

_,

Shizuo Akira

3

_{, Tatsuo Takahashi}

1

_{, Yuri Ikeda-Matsuo}

1

1_{Lab. Pharmacol., Dept. Clin. Pharmacy, Fac. Pharmac. Sci., Hokuriku Univ.,}2_{Dept. Immunol. Genomics, Osaka}

City Univ. Grad. Sch. Med.,3_{Lab. Host Defense, WPI Immunol. Front. Res. Ctr, Osaka Univ.}

(19)

Loss of function in mouse GAD67 leads to emotional impairments

Shigeo Miyata

1

_{, Toshikazu Kakizaki}

1

_{, Kazuyuki Fujihara}

1

_{, Hideru Obinata}

2

_{, Touko Hirano}

2

_,

Junichi Nakai

3

_{, Mika Tanaka}

4

_{, Shigeyoshi Itohara}

4

_{, Kenji Tanaka}

5

_{, Masahiko Watanabe}

6

_,

Manabu Abe

7

_{, Kenji Sakimura}

7

_{, Yuchio Yanagawa}

1

1_{Dept. Gen. Behav. Neurosci., Grad. Sch. Med., Gunma Univ.,}2_{Lab. Anal. Instr., Grad. Sch. Med., Gunma Univ.,} 3_{Div. Oral Physiol., Dept. Oral Funct. Mor., Grad. Sch. Dent., Tohoku Univ.,}4_{Lab. Behav. Gen., RIKEN Brain Sci.}

Inst.,5_{Dept. Neuropsychiat., Sch. Med., Keio Univ.,}6_{Dept. Anat., Fac. Med., Hokkaido Univ.,}7_{Dept. Anim. Mod.}

Devel., Brain Res. Inst., Niigata Univ.

(20)

Glutamatergic neurons from medial prefrontal cortex to dorsal raphe

nucleus regulates maternal aggression in mice

Yoshikage Muroi, Toshiaki Ishi

Dep. Vet. Med., Obihiro Univ.

(21)

The amygdalohippocampal area that projects to the medial preoptic area

mediates aggression toward the infant

Keiichiro Sato, Yumi Hamasaki, Kiyoshiro Fukui, Masabumi Minami, Taiju Amano

Dept. of Pharmacol, Grad. Sch. of Pharmaceut. Sci. Hokkaido Univ.

(22)

Synaptic inputs derived from the central nucleus of amygdala that

suppresses neurons in the rhomboid nucleus of the bed nucleus of the stria

terminals of paternal mice

Shunsaku Murakawa, Haruka Uki, Masabumi Minami, Taiju Amano

Dept. of Pharmacology, Grad. Sch. of Pharmaceutical Science, Hokkaido Univ, Hokkaido, Japan

(23)

Long-term administration of D

2

receptor blocker sulpiride changes social

behavioral pattern in male mice

Hamasaki Yumi, Masabumi Minami, Taiju Amano

Dept. of Pharmacology, Grad. Sch. of Pharmaceutical Sciences, Hokkaido Univ, Hokkaido, Japan

(24)

Blonanserin and 1-(2-Pyriidinyl)-piperazine suppress impulsive action in rats

Hitomi Sasamori

1

_{, Naoya Nishitani}

2

_{, Yu Ohmura}

1

_{, Mitsuhiro Yoshioka}

1

1_{Dept. Neuropharmacol. Hokkaido Univ.,}2_{Lab. Mol. Pharmacol. Kanazawa Univ.}

(25)

Serotonergic activity in the dorsal raphe nucleus is required for

model-based decision making

Yu Ohmura

1

_{, Kentaro Iwami}

2

_{, Hitomi Sasamori}

1

_{, Chiaki Sugiura}

1

_{, Youcef Bouchekioua}

1

_,

Mitsuhiro Yoshioka

1

1_{Dept Neuropharmacol, Hokkaido Univ, Hokkaido, Japan,}2_{Hokkaido Univ Sch Med, Hokkaido, Japan}

(26)

Behavioral Characterization of Dopamine D

5

Receptor Knockout(D

5

KO) Mice

Chiaki Sugiura

Dept. Neuropharmacol. Hokkaido Univ.

(27)

Ameliorating effects of guanfacine, an adrenergic α

2A

receptor agonist, on

AD/HD-like behaviors in an AD/HD model rat, male adolescent SHRSP/Ezo

Taku Yamaguchi, Ryosuke Shinozaki, Tatsuya Oka

Dept. Pharmacother. and Neuropsychopharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.

(28)

Inhibitory effects of local anesthetics on muscarinic receptors: effects on

the Ca

2+

release from intracellular store and recruitment of beta-arrestin.

Shimatani Mari

1

_{, Akihiro Nezu}

2

_{, Akihiko Taimura}

2

1_{Div. Reconstructive Surg Oral Maxillofac Reg., Health Sci. Univ. Hokkaido, Sch. of Dent.,}2_{Div. Pharmacol.,}

Health Sci. Univ. Hokkaido, Sch. of Dent.

(29)

Annexin A2 is involved in activation of AKT upon endothelin-1 stimulation in

melanoma cells

Yuichi Mazaki, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa

Dept. Cell. Pharm., Grad. Sch. Med., Hokkaido Univ.

(30)

Localization analysis of several NCKX2-NCLX chimeras into plasma

membrane/mitochondrial inner membrane

Takayuki Nemoto

1

_{, Tomo Kita}

1

_{, Hideaki Tagashira}

1

_{, Satomi Kita}

1,2

_{, Takahiro Iwamoto}

1

1_{Dept. Pharmacol., Fac. Med., Fukuoka Univ.,}2_{Dept. Pharmacol., Fac. Pharma. Sci., Tokushima Bunri Univ.}

(31)

Distribution of mammal-like melanin concentrating hormone type 1 and 2

receptor expressing neurons in the brain of a basal actinopterygian fish,

Polypterus senegalus

Morio Azuma, Taka-aki Koshimizu

Div. of Mol. Pharmacol., Dept. of Pharmacol., Jichi Med. Univ.

(32)

Receptor functional analysis of leptin resistance by adenosine- BRET

analysis

Toru Hosoi

1

_{, Takenori Matsuura}

3

_{, Anisia Silva}

4

_{, Momoe Wada}

3

_{, Syu Matsuzaki}

3

_,

Michitaka Sugiyama

2

_{, Naoshi Kodama}

2

_{, Ralf Jockers}

4

_{, Julie Dam}

4

_{, Koichiro Ozawa}

2

1_{Dept. Clin. Pharmacology, Facul. Pharmaceutical Sci., Sanyo-Onoda City Univ.,}2_{Dept. Pharmacotherapy, Grad.}

Sch. Biomed. Health Sci., Hiroshima Univ.,3_{Dept. Pharmacotherapy, Sch. Pharm. Hiroshima Univ.,}4_{Inserm U1016,}

Institut Cochin, Dept Endocrinology, Metabolism and Diabetes, Paris, France

(33)

Collapsin response mediator protein 2 was one of targets for 15deoxy

-Δ

12,14

-prostaglandin J

2

Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma

Dept. Pharmaceutic. Health, Himeji Dokkyo Univ.

(34)

Differentiation-inducing factor 1 activates AMP-regulated kinase/Cofilin

pathway to regulate the actin cytoskeleton.

Koichi Miura, Takeru Inoue, Ruzhe Han, Toshiyuki Sasaguri

Kyushu Univ., Fac. of Med. Sci.

(35)

Development of Histamine N-methyltransferase Inhibitors for Brain

Disorders

Takeo Yoshikawa, Rina Otsuka, Yuki Sato, Kazuhiko Yanai

Dept Pharmacol Tohoku Univ Grad Sch Med

(36)

The development of miR-96-5p gene knock out technique by CRISPR/Cas9

system

Nobuko Matsumura

1

_{, Chisato Kinoshita}

1

_{, Toshio Nakaki}

2

_{, Koji Aoyama}

1

1_{Dept. Pharmacol., Teikyo Univ. Sch. Med.,}2_{Fac. Pharma-Sci., Teikyo Univ.}

(37)

Evaluation of seizure sensitivity and potential excitation foci in Phf24-KO

rats

Naofumi Kunisawa

1

_{, Hiroaki Hisadumi}

1

_{, Masaki Kato}

1

_{, Saki Shimizu}

1

_{, Kazuaki Sato}

2

_,

Masato Kinboshi

1

_{, Masao Matsuhashi}

3

_{, Akio Ikeda}

3

_{, Tadao Serikawa}

1

_{, Yukihiro Ohno}

1

1_{Dept. Pharmacol., Osaka Univ. Pharmaceut. Sci.,}2_{Dept. neurol., Ijinkai takeda general Hosp.,}3_{Dept. Epilepsy,}

Mov. Dis. and Physiol., Kyoto Univ.

(38)

Lifelong measurement of locomotor activity and body temperature in

group-housed laboratory mice by wireless power transmission

Kazuhiko Yanai

1

_{, Takeo Yoshikawa}

1

_{, Kenichi Sagara}

2

_{, Shu Sasaki}

2

1_{Tohoku Univ. Sch. Med. Dept. Pharmacol.,}2_{HIKARIDENSHI, CO., LTD}

(39)

Our preclinical support of neurological research approaches using

cerebrospinal fluid

Kohei Araki, Keita Saito, Kotaro Suzuki, Toru Nonomura, Noriyuki Yamazaki

New Drug Research Center, Inc.

(40)

Efforts for promotion of Use of Radioisotopes (RI) -RI Experimental

Protocols for

Beginners-Rikako Azuma

1

_{, Hiroyuki Tsunokuni}

1

_{, Keiichi Matsunami}

2

_{, Masayuki Hara}

3

_{, Shinsuke Katoh}

4

_,

Hiroyuki Iizuka

5

1_{Japan Radioisotope Association,}2_{Grad. Sch. of Medicine, Juntendo Univ.,}3_{Res. Core, Inst. of Res., Tokyo Medical}

and Dental Univ.,4_{Dept. of Health Pharm., Yokohama Univ. of Pharm.,}5_{Sch. of Eng. Environ. Health and Safety}

Office., Univ. of Tokyo

(41)

Structure prediction of the N-terminal regulatory domain of the human

tryptophan hydroxylase 2

Masanori Ootaki

1

_{, Tomoko Hiroi}

2

_{, Yuki Ohta}

1

_{, Yuko Takeba}

1

_{, Keisuke Kida}

1

_{, Hiroaki Matsui}

2

_,

Naoki Matsumoto

1

1_{St. Marianna Univ. Sch. Med. Dept. Pharmacol.,}2_{Inst. Radioisotope Res. St. Marianna Univ. Grad. Sch. Med.}

(42)

Comparison of medication self-management for older adults supported by

nurses at general hospitals and home-visit nursing stations

Kanako Sakane

1

_{, Yuta Kobayashi}

1

_{, Mayumi Miyamoto}

1

_{, Miki Fukuma}

1

_{, Yuko Tsumoto}

1

_,

Hiromi Uchida

2

1_{Shimane Uni., Fac. Med., Dept. Nursing,}2_{Tenri Helth Care Uni.}

(43)

Integrated safety evaluation of benzodiazepines using human iPS cell

technology

Tsunemoto Kazunobu

1

_{, Shigeru Yamada}

1,2

_{, Yasunari Kanda}

1

1_{Div. Pharmacol, NIHS,}2_PEIJ

(44)

Antioxidative activity of fructose 1,6-bisphosphate as a direct free radical

scavenger

Kazue Ogata

1

_{, Kahona Ono}

2

_{, Osamu Tokumaru}

1

1_{Department of Physiology, Facalty of Welfare and Health Sciences, Oita University,}2_{Medical student, School of}

Medicine, Oita University Faculty of Medicine

(45)

ATX- increases intracellular Na

and Ca

concentration in pulmonary vein

cardiomyocytes by activating reverse-mode Na

+

/Ca

2+

exchanger

Taro Saito, Aiko Ohba, Yuta Takano, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka

Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.

(46)

Elucidation of mechanisms that trigger torsades de pointes in drug-induced

long QT syndrome: a simulation study

Kunichika Tsumoto

1

_{, Takao Shimamoto}

2

_{, Akira Amano}

2

_{, Yuhichi Kuda}

1

_{, Mamoru Tanida}

1

_,

Yasutaka Kurata

1

1_{Dept. Physiol, Kanazawa Med. Univ.,}2_{Dept. Bioinfo, Ritumeikan Univ.}

(47)

Different modulatory effects of isoflurane and halothane on

arrhythmogenesis elicited by dofetilide in rabbits.

Satoshi Kawakami, Yoshinobu Nagasawa, Megumi Aimoto, Akira Takahara

Dept. Pharmacol. Therap., Fac. Pharmaceut. Sci. Toho Univ.

(48)

Dulaglutide inhibited perilipin 2-induced atrial fibrillation through the

improvement of atrial impulse conduction slowing in transgenic mice

Nanae Ishida

1

_{, Shogo Yukawa}

1

_{, Satsuki Sato}

2

_{, Jinya Suzuki}

2

_{, Eiichi Taira}

3

_{, Masamichi Hirose}

1

1_{Dept. Pathophysiol. and Pharmacol., Iwate Medical Univ.,}2_{Third Dept. Internal Med., Univ. of Fukui,}3_{Dept. of}

Pharmacol., Iwate Medical Univ.

(49)

Manifestation of proarrhythmic properties of IK

ACh

blocker tertiapin in the rat

dilated atria caused by chronic volume overload

Megumi Aimoto, Ryohei Suzuki, Yuka Taneichi, Yoshinobu Nagasawa, Akira Takahara

Dept. Pharmacol. Ther., Fdt. Pharmaceut. Sci. Toho Univ.

(50)

Comprehensive and rigorous analysis of drug-induced QT interval

prolongation in anesthetized guinea pigs using 11 antihistamines with

clinical reports on adverse drug reactions

Yoshinobu Nagasawa

1

_{, Miki Shimizu}

1

_{, Misa Oshiba}

1

_{, Go Minemoto}

1

_{, Yuichi Kenmotsu}

1

_,

Kengo Kimura

1

_{, Kensuke Omura}

1

_{, Naoki Omuro}

1

_{, Kaori Fujiwara}

1

_{, Haruka Matsuzaki}

1

_,

Kazuko Kobayashi

1,2

_{, Satoshi Kawakami}

1

_{, Megumi Aimoto}

1

_{, Akira Takahara}

1

1_{Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci. Toho Univ.,}2_{Dept. Pharm. Toho Univ. Ohashi Med. Ctr.}

(51)

Characteristics of sudden death in cardiac-specific conditional NCX1

knockout mice

Hideaki Tagashira

1

_{, Satomi Kita}

1,2

_{, Takahiro Iwamoto}

1

1_{Dept. Pharmacol., Fac. of Med., Fukuoka Univ.,}2_{Dept. Pharmacol., Fac. of Pharma. Sci., Tokushima Bunri Univ.}

(52)

Hsp90 contributes to cardiac hypertrophy in the development of heart failure

via regulating c-Raf.

Takumi Itoh, Tetsuro Marunouchi, Emi Yano, Kouichi Tanonaka

Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

(53)

Pathophysiological role of Ca

permeable TRPV2 channel in myocardial

ischemia reperfusion injury

Yuko Iwata

1

_{, Shigeo Wakabayashi}

2

_{, James Pearson}

1

1_{NCVC, Cardiac Physiology,}2_{Osaka Aoyama Univ., Health Science}

(54)

Gender differences in the effect of spontaneous exercise on heart failure in

DCM model mice

Masami Sugihara

1

_{, Ryo Kakigi}

2

_{, Takashi Murayama}

3

_{, Takashi Miida}

1

_{, Takashi Sakurai}

3

_,

Sachio Morimoto

4

_{, Nagomi Kurebayashi}

3

1_{Dept.Clin.Lab.and Med.,Juntendo Univ.,}2_{Fac. Mgmt. & Info. Sci., Josai Int. Univ.,}3_{Dept.Phamacol.,Juntendo}

Univ.,4_{Dept. Health Sci. at Fukuoka, IUHW}

(55)

Development of drugs for anticancer drug-induced cardiotoxicity using acyl

ghrelin and des-acyl ghrelin extracted from the stomach of salmon and tuna

Toshiki Kawashima

1,2

_{, Miki Nonaka}

2

_{, Minoru Kihara}

3

_{, Hidekazu Katayama}

4

_{, Kaori Ohshima}

2,5

_,

Kanako Miyano

6

_{, Kazumi Yoshizawa}

1

_{, Yasuhito Uezono}

2,7

1_{Lab. of Pharmacol. and Ther., Dept. of Pharm., Fac. of Pharmaceut. Sci., Tokyo Univ. of Sci., Chiba, Japan,}2_Dept.

of Pain Control Res., The Jikei Univ. Sch. of Med., Tokyo, Japan,3_{Dep. of Mar. Biol. and Sci., Sch. of Biol. Sci.,}

Tokai Univ., Hokkaido, Japan,4_{Dep. of Appl. Biochem., Sch. of Eng., Tokai Univ., Kanagawa, Japan,}5_Patho.,

Immunol. & Microbiol., Grad. Sch. of Med., Univ. of Tokyo, Tokyo, Japan,6_{Div. of Cancer Pathol., Natl. Cancer}

Ctr. Res. Inst., Tokyo, Japan,7_{Div. of Support. Care Res., Explor. Oncol. Res. & Clin. Trial Ctr., Natl. Cancer Ctr.}

Res. Inst., Tokyo, Japan

(56)

Arresten, a cleaved fragment of type IV collagen α1 chain, regulates

functions of cardiac fibroblasts and left atria

Akira Sugiyama, Shiho Tajima, Riki Yamamoto, Kosuke Otani, Muneyoshi Okada,

Hideyuki Yamawaki

Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

(57)

Chronic toxicity assessment of nilotinib using human-induced pluripotent

stem cell-derived cardiomyocytes

Hayashi Sayo, Ayano Satsuka, Shota Yanagida, Yasunari Kanda

Div. Pharmacol, NIHS

(58)

Assessment of drug-induced contractility in iPS-CMs by cell motion imaging

and cell-induced electrical impedance monitoring.

Satsuka Ayano, Sayo Hayashi, Yasunari Kanda

Div. Pharmacol, NIHS

(59)

Tanshinone VI promotes the differentiation of cardiosphere-derived cells

into cardiomyocytes.

Tetsuro Marunouchi, Minami Ikoshi, Emi Yano, Kouichi Tanonaka

Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

(60)

The effect of chemical sympathetic dennervation on the postnatal heart

development.

Takuro Numaga-Tomita

1

_{, Hiroyuki Kawagishi}

1

_{, Tsutomu Nakada}

2

_{, Mitsuhiko Yamada}

1

1_{Dept Mol Pharamcol, Sch Med, Shinshu Univ,}2_{Res Center Supp Adv Sci, Shinshu Univ}

(61)

A novel intracellular drug-delivery system specific for cardiomyocytes using

RNA aptamer

Takeshi Honda

1

_{, Hiroki Sakai}

1

_{, Makoto Inui}

1,2

1_{Dept. Pharmacol. Grad. Sch. Med.,}2_{YIC Rehab. Col.}

(62)

Analysis of the molecular mechanism of compensatory

hypertrophy-associated enhancement of salivary secretion using the intravital Ca

2+

imaging and gene analysis.

Akihiro Nezu

1

_{, Shigeru Takahashi}

2

_{, Takao Morita}

3

_{, Akihiko Tanimura}

1

1_{Div. Pharmacol, Health Sci. Univ. Hokkaido Sch. Dent.,}2_{Dept. Oral Functional. Anat., Hokkaido Univ. Grad. Sch.}

Dent. Med.,3_{Dept. Biochem., Nippon Dent. Univ. at Niigata}

(63)

Cdc42-deficiency induces salivary hyposecretion and maintains lacrimal

secretion in mice.

Nagase Haruna, Akiko Shitara, Yuta Ohno, Masanori Kashimata

Asahi Univ., Dent., Pharmacol.

(64)

Regulation by purinergic signal of glucose-induced insulin secretion from

iGL insulinoma cells.

Masa-aki Ito, Chinatsu Machida, Kazuki Yoshida, Isao Matsuoka

Lab. Pharmacol., Fac. Pharm, Takasaki Univ. Health and Welfare

(65)

Effect of sucrose beverage intake on blood glucose level and insulin

secretion

Sato Sachiko, Yukiko Kondo, Eiichi Taira

Dept. of Pharmacol., Iwate Med. Univ., Morioka, Japan

(66)

Thyrotropin receptor antibodies (TRAbs) induced by Epstein-Barr virus

reactivation: Significance on Graves’ disease

Nagata Keiko

1

_{, Kazuhiko Hayashi}

2

_{, Yukio Satoh}

3

_{, Mitsuhiko Osaki}

4

_{, Junichiro Miake}

1

_,

Yoshinori Ichihara

1

_{, Tatsuya Sawano}

1

_{, Yuhang Zhou}

1

_{, Agung Priyono}

1

_{, Kazuhiko Matsuzawa}

1

_,

Takeshi Imamura

1

1_{Div. Pharmacol. Fac. Med. Tottori Univ.,}2_{Pathol.Dept. Fac. Med. Tottori Univ.,}3_{Div. Developmental Biol. Sch.}

Life Sci. Fac. Med. Tottori UNiv.,4_{Div. Exp. Pathol Sch. Life Sci. Fac. Med. Tottori Univ.}

(67)

Possible roles of autophagy related proteins ATG2A and ATG7 in the

differentiation of human endometrial stromal cells

Saito Yuri

1

_{, Junya Kojima}

2

_{, Atsuya Tsuru}

1

_{, Mikihiro Yoshie}

1

_{, Kazuya Kusama}

1

_{, Kazuhiro Tamura}

1

_,

Hirotaka Nishi

2

1_{Dept. Endocrine Pharmacol.,Tokyo Univ. Pharm. & Life Sci.,}2_{Dept. Obstet. & Gynecol., Tokyo Med. Univ.}

(68)

Effect of adipose tissue-derived stem/stromal cells on muscle atrophy

Yuki Ohta

1

_{, Tsukasa Kobayashi}

1

_{, Yuko Takeba}

1

_{, Masanori Ootaki}

1

_{, Keisuke Kida}

1

_,

Minoru Watanabe

2

_{, Taroh Iiri}

1

_{, Mitsuko Takenaga}

3

_{, Naoki Matsumoto}

1

1_{Dept. of Pharmacol., St Marianna Univ. Sch. of Med.,}2_{Inst. for Anim. Exp., St. Marianna Univ. Grad. Sch. of Med.,} 3_{Inst. of Med. Sci., St Marianna Univ. Sch. of Med.}

(69)

17β-estradiol attenuates sepsis-induced myopathy in mice

Shunya Takeshita, Chihiro Hibi, Kazuho Sakamoto, Junko Kurokawa

Dept. Bio-Info. Pharmacol., Univ. Shizuoka

(70)

Identification of binding site for a novel RyR1-selective inhibitor

Takashi Murayama

1

_{, Nagomi Kurebayashi}

1

_{, Takuya Kobayashi}

1

_{, Haruo Ogawa}

2

_,

Masami Kodama

2

_{, Shuichi Mori}

3

_{, Hiroyuki Kagechika}

3

_{, Takashi Sakurai}

1

1_{Dept. Pharmacol., Juntendo Univ. Sch. Med.,}2_{IQB, Univ. Tokyo,}3_{IBB, Tokyo Med. Dent. Univ.}

(71)

Characterization of novel RyR1 selective inhibitors identified by ER Ca

measurements

Matsukawa Hiroyuki

1

_{, Takashi Murayama}

1

_{, Takuya Kobayashi}

1

_{, Nagomi Kurebayashi}

1

_,

Toshiko Yamazawa

2

_{, Mari Ikegami-Yuasa}

3

_{, Shuichi Mori}

3

_{, Hiroyuki Kagechika}

3

_{, Takashi Sakurai}

1

1_{Dept. Pharmacol., Juntendo Univ. Sch. Med.,}2_{Dept. Mol. Physiol., Jikei Univ. Sch. Med.,}3_{IBB, Tokyo Med. Dent.}

Univ.

(72)

Effects of Palmitoleic acids on skeletal muscle differentiation in

hyperglycemic environment.

Yayoi Tokunaga

1

_{, Hitomi Yoshizaki}

2

_{, Akiyo Toriumi}

2

_{, Chisato Ishida}

3

_{, Ritsuko Kawaharada}

4

_,

Masatoshi Hori

1

_{, Akio Nakmura}

2

1_{Lab. of Veterinary Pharmacol., Grad. Sch. of Agr. and Life Sci., Tokyo Univ.,}2_{Department of Food and Health}

Sciences, Jissen Women’s University, Hino, Japan,3_{Department of nutrition, Japanese Haramachi Red Cross}

Hospital, Japan,4_{Department of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki, Japan}

(73)

Evaluation of the usefulness of three-dimensional organoid culture in the

drug screening of non-alcoholic steatohepatitis (NASH) disease

Yamamoto Haru

1

_{, Megumi Yamanaka}

1

_{, Elbadawy Mohamed}

2

_{, Tatsuya Usui}

1

_{, Kazuaki Sasaki}

1

1_{Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo}

University of Agriculture and Technology,2_{Department of Pharmacology, Faculty of Veterinary Medicine, Benha}

University

(74)

Disruption of steroidogenic acute regulatory protein-related lipid transfer

domain containing 10 (STARD10) prevents the development of nonalcoholic

steatohepatitis (NASH)

Masanori Ito, Daisuke Ohshima, Yoshinori Mikami, Taichiro Tomida, Satomi Adachi-Akahane

Department of Physiology, Faculty of Medicine, Toho University

(75)

Effects of Bezafibrate on Carbon Tetrachloride and T0901317-Induced

Nonalcoholic Steatohepatitis Model

Yukiko Kawasaki, Shoko Otsu, Yuri Noda, Takahito Imaizumi, Hisami Matsushita, Katsumi Endo,

Yasushi Hirasawa

Nihon Bioresearch Inc.

(76)

Roles of heparan sulfate against CCl

4

cytotoxicity in HepG2 cells

Takuro Matsuzawa, Ai Shimane, Kazuhiko Yanai, Takeo Yoshikawa

Dept Pharmacol. Tohoku Univ Grad Sch Med

(77)

Platelets attenuate monocrotaline-induced liver injury

Fumisato Otaka

1,2

_{, Yoshiya Ito}

1,2

_{, Kanako Hosono}

1,2

_{, Kou Hatanaka}

1,2

_{, Wasaburo Koizumi}

3

_,

Hideki Amano

1,2

1_{Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences,}2_Department

of Pharmacology, Kitasato University School of Medicine,3_{Department of Gastroenterology, Kitasato University}

School of Medicine

(78)

Expression of the growth-related factors in the liver of fetal rats

Tsukasa Kobayashi

1

_{, Yuko Takeba}

1

_{, Yuki Ohta}

1

_{, Masanori Ootaki}

1

_{, Keisuke Kida}

1

_,

Minoru Watanabe

2

_{, Taroh Iiri}

1

_{, Naoki Matsumoto}

1

1_{Department of Pharmacology, St Marianna University School of Medicine,}2_{Institute for Animal Experimentation,}

St Marianna University Graduate School of Medicine

(79)

CRAC channel blockers attenuate the activation of human hepatic stellate

cells

Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura

Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

(80)

The alternation of adenosine-related genes likely progress HSC activation in

inflammatory condition.

Naoki Dohi

1

_{, Momoka Yamaguchi}

1

_{, Sin-ya Saito}

1,2

_{, Tomohisa Ishikawa}

1

1_{Dept. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka,}2_{Fac. Vet. Med., Okayama Univ. Sci.}

(81)

The formation of lymphatic vessels and macrophages contribute to liver

repair after liver injury

Shuji Nakamoto

1,2,3

_{, Yoshiya Ito}

1,2

_{, Takuya Goto}

1,2,3

_{, Kanako Hosono}

1,2

_{, Ko Hatanaka}

1,2

_,

Masataka Majima

1,2,4

_{, Hideki Amano}

1,2

1_{Dept. Mol. Pharmacol., Kitasato Univ. Grad. Sch. Med.,}2_{Dept. Pharmacol., Kitasato Univ. Sch. Med.,}3_Dept.

Surg., Kitasato Univ. Sch. Med.,4_{Dept. Med. Therap., Kanagawa Inst. Tech.}

(82)

In vivo S-allyl-L-cysteine and some analogues accelerates liver regeneration

in 70% partially hepatectomized rats.

Kazuki Kurihara

1

_{, Hajime Moteki}

1

_{, Hideshi Natsume}

2

_{, Masahiko Ogihara}

1

_{, Mitsutoshi Kimura}

1

1_{Dept. Clin. Pharmacol., Fac. Pharma. Sci., Josai Univ.,}2_{Dept. pharmaceutics, Fac. Pharma. Sci., Josai Univ.}

(83)

Functional analysis of FSGS-associated TRPC6 channels and its

relationship to early-onset and late-onset of the renal disease

Ryo Okada

1

_{, Tatsuya Komaki}

1,2

_{, Onur K. Polat}

3,4

_{, Hideyuki Kobayashi}

1

_{, Takanori Kihara}

2

_,

Masayuki X. Mori

1

1_{Bio-materer. Chem., Sch. Med., UOEH,}2_{Graduate School of Environmental Engineering, The University of}

Kitakyushu,3_{Dept. Synth. Chem. Biol. Chem., Grad. Sch. Eng., Kyoto Univ.,}4_{Rush Univ., Chicago, USA}

(84)

Inhibition of CRAC channel current by TRPV1 channel agonist and

antagonist in RBL cells

Ayumi Nakayama, Minoru Wakamori

Div. Mol. Pharmacol. Cell Biophys., Grad. Sch. Dent., Tohoku Univ.

(85)

Role of TRPM7 channel in pancreatic cancer

Hosokoshi Atsuki

1

_{, Nobuaki Takahashi}

2

_{, Reiko Sakaguchi}

1

_{, Atsusi Masamune}

3

_{, Hiroshi Harada}

4

_,

Yasuo Mori

1

1_{Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ,}2_{The Hakubi Cent., Kyoto Univ,}3_Dept.

Gastroente., Grad. Sch. Med., Tohoku Univ,4_{Dept. Genome Dynamics., Radiation Biology Cent., Grad. Sch. Bio.,}

Kyoto Univ

(86)

TRPC channels selective compounds for novel fibrotic disease treatment

and trafficking of antisense oligonucleotides

Tomorrow Amatani

1

_{, Yuuya Kasahara}

2

_{, Masahito Shimojo}

3

_{, Motohiro Nishida}

4,5

_{, Ryu Nagata}

3

_,

Satoshi Obika

2,3

_{, Yasuo Mori}

1

1_{Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ,}2_{Natl. Inst. Biomed. Innov. Health. & Nut.}

(NIBIOHN),3_{Dept. Bioorg. & Chem., Grad. Sch. Pharmaceut. Sci., Osaka Univ,}4_{Dept. Pharm., Grad. Sch., Kyushu}

Univ,5_{Nat. Ins. Physiol. Sci. (NIPS), Nat. Ins. Natural Sci. (NINS)}

(87)

Regulation of mitochondrial activities by TRPA1 channel

Yoshiaki Hasegawa

1

_{, Satoru Hamano}

1

_{, Yasuo Mori}

1

_{, Nobuaki Takahashi}

1,2

1_{Lab. Mol. Biol. Grad. Sch. Eng. Kyoto Univ.,}2_{The Hakubi Cent., Kyoto Univ.}

(88)

Different Zinc sensitivity of TRPA1 between human and chicken.

Masaki Matsubara, Noriyuki Hatano, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki

Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi Gakuin University

(89)

C-terminal domain regulates the plasma membrane localization of aquaporin

-5

Shin-ichi Muroi, Yoichiro Isohama

Lab. Appl. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. of Sci.

(90)

Characterization of G-protein coupled receptors selectively localized in

primary cilia in ciliated cellular models

Yuki Kobayashi

1

_{, Nobuya Nishimura}

1

_{, Yuki Tokubaga}

1

_{, Tatsuo Miyamoto}

2

_{, Yumiko Saito}

1

1_{Hiroshima Univ. Grad. Sch. Integrate Sci. Life,}2_{Hiroshima Univ. Res. Inst. Radiobiol.}

(91)

A dual prokaryotic (E. coli) expression system (pdMAX)

Manabu Murakami

1

_{, Agnieszka Murakami}

1

_{, Shirou Itagaki}

2

1_{Department of Pharmacology, Hirosaki University Graduate School of Medicine, Hirosaki,}2_{Collaboration Center}

for Community and Industry, Sapporo Medical University