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Department of Molecular Physiology Division of Physical Fitness
Shigeru Takemori, Professor and Director Hideki Yamauchi, Assistant Professor
General Summary
Research activities in our division have been focused on the plasticity of skeletal muscle and preventive medicine against metabolic syndrome in terms of exercise physiology.
Research Activities
Ubiquitin proteasome and autophagy
-lysosome systems in unloading induced skeletal muscle atrophy
Ubiquitin proteasome systems are considered to act in coordination with autophagy
-lyso- some systems. We investigated the involvement of neural precursor cell expressed devel- opmentally down
-regulated protein 4 (Nedd4) and autophagy
-related proteins in unload- ing induced muscle atrophy with a specific focus on age dependency. Unloading induced higher expression of ubiquitin ligase Nedd4 and autophagy
-related proteins, especially in aged rats, independently of intermitted reloading sufficient for preventing atrophy.
Reloading may have induced an anabolic process that overwhelms the catabolic process of the ubiquitin
-autophagy system.
Site
-specific effects of nutrition and exercise on rat musculoskeletal system
Both nutrition and exercise are necessary to maintain musculoskeletal function. We stud- ied the site
-specific effects of nutrition and exercise on the musculoskeletal systems of growing rats. Dietary restriction suppressed exercise
-induced down
-regulation of myo- statin with a corresponding increase in muscle mass in the plantaris muscle but not in the soleus muscle. Exercise selectively increased the bone volume and mineral density of tra- becula in metaphyses. This increase was suppressed by dietary restriction. We concluded that dietary restriction suppresses the exercise
-induced growth of the musculoskeletal system differentially in a site
-specific manner.
Effects of daily exercise with dietary restriction on fatty liver and skeletal muscle mor- phology in Zucker fatty rats
Daily exercise and dietary restriction have been strategies for improving obesity
-related diseases. We studied the effects of daily exercise or dietary restriction or both on fatty liver and the morphology of skeletal muscle in genetically obese Zucker rats. Daily exer- cise combined with dietary restriction, but not dietary restriction alone, improved insulin resistance, hyperlipidemia, fatty liver, and hepatic fatty acid oxidation with higher expres- sion of carnitine palmitoyl
-coenzyme A transferase 1. In addition, daily exercise com- bined with dietary restriction attenuated lipid accumulation and mitochondrial swelling within myofibers. These findings correlated with improvements in insulin resistance and
Research Activities 2014 The Jikei University School of Medicine
東京慈恵会 医科大学 電子署名者 : 東京慈恵会医科大学 DN : cn=東京慈恵会医科大学, o, ou,
[email protected], c=JP 日付 : 2016.04.15 14:43:22 +09'00'
