シルクフィブロイン由来小口径人工血管を埋植したラット腹部大動脈の生体反応に関する病理学的研究
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(14) ˻͠. ʏÖʾÙY:7TϏʓɥ[ɇˠĤϛőʀjͲʾÙsÃNjVGNʓɥ̊ǚ[ű ĤYlnϛ¬wvUƱ2Ķn½BmpT7o3¬§±µ´¹«4ϛ 7rko3¬§4XW[ȍG7ʓɥ̊ǚʣ<ʪŧGϛL[ʢʣȼΆ<ŵ=? űĤGT7o1ʓɥ̊ǚʣ[X;UiϛʇYĠ̙ʺĤʤ\ŭĝôłY6nϛ̷ ̺ǑNjʢǓϙʉNjʤϛNj˗ȵŪϚ[İŕVGTŏϋ͊EpT7o1Áʜ͉ɀU \̷̺ǑNjʢǓYloɋ̌\ƭΧ˧ 740 »ÑƂŜGϛɋŕ[˕ 1 Ýϙ2012 ƭϚ VXQT7o(24)1ǝ<ŚU\Ǔ̌Ȉ\ɬƖôłY6o<ϛʓɥ̊ǚ[ȅŐYl oĠ̙ʺĤʤ[ÊΫ:l`ɞʧYR7T\æɿVGTɢʮƱ<ϕ71 ʉNjʤϛNj˗ȵŪXW[NjʢǓϛ ̛ȵŪϛ̛Ď̺XW[̛̺˜ʢǓ[İŕ\ Ġ̙ʺĤʤU6o<ϛLp×ŲYiȤȶĠ̙ʢǓϙPeripheral Arterial Disease:PADϚ [İŕVGTiʶmpT7o1PAD \ĝϗjˣƘʣs̔șVGNĠ̙ʺĤYl nȤȶ̺˜YΥŪs=NIʢǓU6nϛ¾̢Ġ̙XW[ΥŪYlQTϛFontaine ďύYʼEpol8XɄ̖[Þ¾ϛ˯̄[ůɋV7QNʣűsƷ=ͫCI(15)1 ̷̺̐\ɋÎ[ʯǹʫXİŕV\XmX?TiϛǓ̌[ QOL s̱G?Þ¾EK. . .
(15) oNhϛL[Ή̻ʈɟYǎHNɞʧ<nj͆VXo(13)1PAD [ɞʧVGT˕º Y̋9mpT7o[\ϛʓɥ̊ǚ[ȅŐYlnϕ̗̺ʤϛˣƘʣϛϕ̺śXW sɉƫĤIoȎɠU6o1đȢɏβY6o Fontaine%Ʊ[Ǔ̌YƑGT\ϛΌĠ ʧɠ[c;YϛȤȶ̺˜ǭƹ̶ϛǧ̺ƕȪ̶XWYlo̶ʆʧɠ<̻rpo1 G;GϛFontaine'-(Ʊ[ΝʤäYƑGT\ą˄ʫXɞʧ\ğȭ<X?ϛŲ˄ʫ XǠ̼<nj͆VEpo(65)1CCU̻rpol8X̺˜ʣYƑIoŲ˄ʫǠ̼\ º̫Y̺̻ćƴ̼Vʼn]pϛÅY}¹²ɞʧVxǠ̼YďύEpo1 ė̌[}¹²ɞʧ\ςèͅʫU6oCVsʇNJVGϛ²¹µYlo̺˜ ǭƹjϛŁȗYµsʕ7o̼ƶiʻ˒EpT7o<ϛ̈ǓΖÝ[̺˜[ ̹̻ϛŷEjL[Ý̇Ylnĕ˧EpoV78¬±<ƂŜIo(59)1ºȎϛ ǃ̌[xǠ̼\̨Ƨ̺˜jÑƣ̺˜sʕ7ṄǼǠ̼U6o(24)1G;G X<mϛʏȗɽUƈʕĤEpT7oÑƣ̺˜\X?ϛL[ǜ̂s͗çIoCV \ŖνU6o<ϛNV9]ǁ 6 mm [ ePTFE (expanded polytetrafluoroethylene ) j Dacron sʕ7Nŧŀ[ 3 ƭǃ:l` 5 ƭǃΦƂʍ\ 20%(39)j 40-50%(42)V; XnÞ71 Ǡ̼ǜ̂;mĒȌIoVŲ̌̌ͱ[̨Ƨ̺˜sãʕIoCV<ʑǕʫU\6. . .
(16) o<ϛºȎŲƧ̺˜[ãʕYiȽ2Xŏϋɽ<6o1IXrPϛ̨Ƨ̺˜s ǷĶIoǠ̼<Ǔ̌[ͤǫVXoCVϛ̇ǼΖÝ[ xYΑGT̺˜sΓǩ GXAp]XmX7CVXW<6o1eNϛC[l8XʢǓsiRǓ̌[ŧŀϛ IJYIUY̨Ƨ̺˜<ãʕEpT7NnϛeNÔ[ʢǓYlQT̨Ƨ̺˜s ãʕU=X7ŧŀi6o(47, 55, 58, 85)1ʇYˣƘʣ˖[̺˜YζƊsiRǓ̌ U\ϛ̈ǓΖÝ×Ų[̺˜iʺ?T̘?XQT7oĻ̖Ǒ<ϕ7Nhϛ̨Ƨ̺ ˜sǷĶIoCV̨ß<ŖνU6oŧŀiƖX?X71×½[CV;mƕĸǁ ϙ-6 mmϚU÷pNΦƂʍsʼIÑƣ̺˜<ĔʕĻ̖U6p]ϛɞʧ[Γǩ̐ <ŵ=?Ư<oCVYXo1 ʏŜʯǁ 3 mm [ ePTFE ̈́Ñƣ̺˜iƨͦEpT7o<ϛΤE\Ȉ cm U6 nϛÅYúŶǑNjʢǓsȞIoƕþ[ Blalock-Taussig ʷ˲̼ϙϓ¾Ġ̙ ̓Ġ ̙®µ̼ϚYãʕEpT7o<0ΦƂǑsìRNhY̼ǃǧ̺ƕȪʧɠ< nj͆U6o1ŵ¸ÃĸǁÑƣ̺˜ϙ.6 mmϚU\ϛePTFE j Dacron XW[˪Ȧ <̧ưʏŧUƯ?ãʕEpϛ̬ŻXǜ̂sʼGT7o1G;GϛŁH˪Ȧsƕ ĸǁ[Ñƣ̺˜YãʕIoVȒȢΥŪXWsʓHϛΤȢʫXΦƂ\džmpT7 X7(20)1L[ʑʗVGTϛCpm[˪Ȧ<Ñƣ̺˜Ynj͆VEpoʇNJsɱN. . .
(17) GT\7o<ϛƕĸǁÑƣ̺˜Ynj͆VEpo͆ØsɱNGT7X7;mOV ̋9mpT7o(11, 45, 62)1ƕĸǁ[Ñƣ̺˜YəhmpT7oŵ=XʇNJ\ 2 R6nϛȒȢΥŪ[İŕVXo̺ȲYƑGTǧ̺ȲǑsȞIoCVVϛÃΤȢ U[ΥŪ[İŕVXoą̤̑įsǥĕIoCVU6o(42, 53, 54, 57, 72, 91)1 šȸǃȒȢ[̺ȲƽǜsΫ@NhY\ϛÑƣ̺˜Y̺Ȳ<ÕʳGY?7˪Ȧ sʕ7oOAUX?ϛšȸǃYÑƣ̺˜[ą̾σ<̺˜ąʬ˭̕YlQT͇r poCV<Ν͆U6o1̺˜ąʬ˭̕\̺ɦV̺˜ŮYʓHoJnǎĜYĴǎ GºΛĤː˪ϙNOϚsȆĎIoCVYlQTϛ̺ɩČřjąʬ˭̕[ĚŭɎ YͫŕIo̺˜ąòσ[ʉˏsΫ7U7oVEpo(83)1C[šȸ̺˜[ąʬĤ Y:Ao̺˜ąʬ˭̕[ʗȨ\ϛŅŀΖ;m[ÜƚYloi[Vϛ̺ɩÃ[ą ʬėϑ˭̕<ƇʳGTŭɎIoi[<̋9mpT7o(57)1G;Gϛąʬ˭̕[ ŭɎήʜȈ\ςƫYƕE?ϛŅŀΖ;m[Üƚ\ 1 cm ˈƱU6oVEpϛ̺˜ Āß[ąʬĤsΎǜIoNhY\ϛŅŀΖ×Ų[̺˜ÃŹΖU[ąʬĤ<Ν͆ YXo(57)1CpeU[ʸˌYlnϛŅŀΖ×ŲU[ąʬ˭̕jąʬėϑ˭̕[ ǹʳ\ϛšȸ̺˜a[̦İ˼˷XW[̨Ƨ˯̄[èÿYlnêΉEpoCV< Ȕm;VXQT:nϛąʬĤYVQTšȸǃ[̺˜[̮̎˯̄ƽǜϛ7rko. . .
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(20) m;YXQNCV;mϛćʓħʧY:7TͮŧȦϙ®¦¹²ϚYXQN ǃY̨Ƨ˯̄ẎǼEpo7rko±±µ[Ʉʹ<ɢʮEpT7o(3, 53, 79, 89, 93)1 CpeU[Ñƣ̺˜YΨIoʸˌ;mϛŵ¸ÃĸǁÑƣ̺˜YƑGTəhm po͆Ø<Ȕm;VXQT=N1Ñƣ̺˜\ΤȢYrNQTßąYƂŜIoi [U6nϛL[Ʉ̖sʩǽIoNhY\ϛų?[Ǒ̖sȞIonj͆<6o1e JϛÑƣ̺˜\ʓßąYšȸIoCV;mʓßΑŀǑ<̬?ϛɒǑϛʩ<t ǑϛǧİǑ<X7CV<Ν͆U6o1EmYšȸΖÝ[ǘȯ\šȸ̺˜[ĞĤ jǓΖ[ɞʨΊƳYRX<oNhϛÑƣ̺˜[ǘȯYƑIoǪǧǑinj͆VE po(81)1Cpm[ȧØYƑGTϛSF\ėGN²VŁȽYʓßΑŀǑ<ϕ ?ϛɾɒǑeNɾĖɹǑU6oCV;mϛ˪ȦVGT[ΑǑsȞGT7oV̋ 9mpo(35)1;ƭϛ˯̄ƣƃYŤS7NʸˌYlnϛĞĤU\X?̨Ƨ˯̄Y lȯǼsȢǂIoʸˌifmpϛSFiC[ʇNJsȞGT7oV79o(28, 53, 93)1 Ñƣ̺˜\ǓΖYšȸIoCVYlnãʕIoNhϛšȸΖÝYΑGN x jΤE[i[<ÿǠĻ̖UϛšȸǠ̼[ε[Ñƣ̺˜[ȃáǑ[̬E:l`. .
(21) šȸǃ[Ñƣ̺˜;m[̺ɩɶpsµ´¹²U=oCViΝ͆U6o1SF \ĝƣ<ƌȕU6nϛʇYÑƣ̺˜Y:7T\˼˷[ŷEj˽fȎXWsű9 oCVUȽ2XΤEϛŷEϛƽ[Ñƣ̺˜sá̈́U=o1eNϛȥʸˌUá̈́ GNƕĸǁ[Ñƣ̺˜\ϛŤʭ[á̈́ǃYL[ŇŗY¹wµsȏGT7 o1¹wµsȏICVYlnϛŤʭ[f[ŧŀYfmpoɅɽVEpo ŅŀΖ[̘ƸǑjϛšȸǃ[̺ɶp[ŏϋs͍ɜIoCV<Ļ̖YXo1SF [ 3 ɆøʫʇNJsĔʕGϛŤʭOAUX?¹wµVGTĔʕIoCViĻ̖ U6n(7)ϛC[σUi SF [÷ÝǑsɥ;ICV<ȢǂU=o1 Ñƣ̺˜snj͆VIo˹ǐǠ̼[εY\ϛL[Ǔ̌YΑŀIoΤEjƽ[Ñ ƣ̺˜sΓǩIonj͆<6o1ʏŜϛ̺˜ąʬ˭̕(46)j̺˜[ȼǜsêΉIo ʮʫUϓϔ˭̕(70)s6m;HhÑƣ̺˜ąYȁˉGTá̈́Io˭̕ȁˉŠÑ ƣ̺˜jϛ̨Ƨ˯̄sʕ7ox|¯¹¡Vʼn]poÑƣ̺˜[ȞʕǑ<Ŧ ņEpT7o<(49)ϛCpm[̺˜U\á̈́YȗΧ<;;nϛeNΤȢΧìƂI oCV<U=X7V7QNΝ˟Xŏϋɽ<ƂŜIo1L[ɽ SF [ŧŀY\ºƱ YŁHŌͩ[Ñƣ̺˜sŵΟYá̈́IoCV<U=ϛEmYɴ̯ϙ|¹³ ¹¡ɴ̯j~ɴ̯ϚYlnΤȢΧ[ìƂiĻ̖U6o1. . !.
(22) C[l8YSF\Ñƣ̺˜Ynj͆XʇǑOAUX?ϛƕĸǁÑƣ̺˜[ΥŪ[ İŕVXo̺Ȳƽǜjϛą̤̑įsΫ@Nh[ʇǑiĄZó9T:nϛƕĸǁ Ñƣ̺˜[÷pN˪ȦVXoĻ̖Ǒs˅hT7o1IJ[ʸˌU\SFʗȨ[ƕ ĸǁÑƣ̺˜ϙǁ1.5 mmϛΤE10 mmϚs°̡ΖŵĠ̙YšhͽtOεϛš ȸ1ƭǃYePTFEUá̈́EpNÑƣ̺˜lniȞǖYϕ7ΦƂʍsʼGNϙ85% vs. 30%, P < 0.01Ϛ (20)1EmYϛ̺˜ąʬ˭̕jƬɵ˗˭̕<Ñƣ̺˜ąòσ UšȸǃȒȢYʻ͚EpoVViYϛSF<ď͍EpT̨Ƨ˯̄Ẏ=ǼrQT 7o[<ʻ͚EpT7o(20, 53)1C[l8YƕĸǁÑƣ̺˜[˪ȦVGTSF[ ȞʕǑ<ʼEpRR6o<ϛeOL[͙˭X͗ç\XEpT7X71LCUȥ ʸˌU\ϛSF[ŤʭOAUX?L[¹wµVGT[ȞʕǑsʼINh[ ͗ç˥YR7Tȹ͑Gϛ°sʕ7NƕĸǁÑƣ̺˜[ΦʩYnj͆XȍNX ƈϒ˥sʻ˒IoCVVGN1. . ".
(23) ˕ 1 ˓ SF sʕ7NƕĸǁÑƣ̺˜[Ǒ̖͗çXm`Y°̡ΖŵĠ̙šȸ ǃ[˯̄ƃʫ͗ç. ͡͏ ʏŜãʕEpT7oº̫ʫXÑƣ̺˜\ϛŤʭVL[ŇnYȏEpo¹ wµ[˯fŀrKYlná̈́EpT7o1Ťʭ\Ñƣ̺˜[ȥßΖďU6nϛ ƅĀǑ\iPqt[CVϛšȸǃ[ȒȢ:l`ÃȢ×έY:Ao̺Ȳƽǜjɼ ʤXW[ʓßĴǎsǥ9ϛą̤[ƽǜsêΉGϛΑƱXƺƱs˷ǯGRR̨Ƨ ˯̄VºßĤGϛÜƚǑs\HhVIo̺˜[ʓʑʫɄ̖sȞIoCV<͆ə Epo(71) 1C[l8XɄ̖só9oNhY\7rko3˘4VGTU\X?ϛ ȼΆVGT[ʇǑinj͆VEpo1ʇY̨Ƨ˯̄V[ºßĤV̇Ǽs̋ǛIo Vϛ̨Ƨ˯̄<Ñƣ̺˜ąa6oˈƱÿnͽgCV<əhmpo(20)1PETj ePTFE\Ñƣ̺˜[Ťʭ[˪ȦVGTΤƭãrpT=N(39, 42)1PET\˽fj̄ nV7QNƽʈϛµsΫ@Nh[̡̹ȼΆsVoCV<U=ϛ7Jpi µͩ[ńʳϛ̺ƕȪ[ˡʳϛ˭̕Õʳ[êΉYRX<o<ϛ7rkoǧ̺ ȲǑ\ʼEX7(39)1ºȎϛePTFE\L[ϕ7ʠɘǑ[Nhϛµͩ[ńʳ. . .
(24) Ǒj˭̕[ǹʳǑ<Þ?ϙ7rkoǧ̺ȲȦȋ[1RϚϛʟʆĴǎiƖX7[s ʇNJVIo(39, 42)1 ¹wµ\Ťʭ[iRʇǑs̓ƆIoʮʫUãʕEpol8YXQN(7, 32, 35, 48, 53, 56, 91)1Ñƣ̺˜šȸǃ[ŵ=XŏϋɽVGTϛ̺ɦćΦǃYÑƣ ̺˜ȥß:l`Ρˋ;mʓHo̺ɩɶĎ<6Bmpo1̺ɩɶĎ<ų7ŧŀ\ šhͽfsƆÉIoCV<U=X71C[ɶĎsΫ@Nh[ϜR[Ȏ˙VGTϛ Ǔ̌[̺ɩsÑƣ̺˜[̾σYŨnϛČřEKT\eNŨoV78CVs̆n ͿI¢³´wµ<̻rpT7o(73)1¢³´wµ[ŏϋɽVG T\ϛȃá<ʁλUǠ̼[ȗΧ<Τ?XQTGe8CVϛ˹ǐ[Ǡ̼YƑǎU =X7CVϛ£±µ<ǦÀEpT7oäU\̨Ƨ̺Ylo¢³´wµ <X7CVXW<6Bmpo(39)1C[NhʏŜ\°µϙGelϚj°¹ µ7QN˪Ȧ<̺ɩɶĎsΫ@Nh[¹wµVGTʕ7mpT7o(19, 38)1Cpm[¹wµĘ\ϛšȸǃºƇȢΧUʓßYńĵEpoCVYl nŤʭa[˯̄èÿ[żBYXmX7V̋9mpT7o(19, 38, 74)1G;Gϛʇ Y°¹µ[ŧŀY\šȸǃ[ɼʤĴǎjʩʂXW<ŏϋVXoCV<6o (37)1PETj ePTFË́[ÃĸǁÑƣ̺˜ϙ.6 mmϚ\̧ư[ʏŧU̬ŻXΦƂ. . .
(25) ˱ȭsʼGT7o(40, 50, 80)1ºȎUŁH˪Ȧsƕĸǁϙ< 6 mmϚYãʕGNŧ ŀϛ̺ȲƽǜjʉˏXW<İŕUȒȢYΥŪGTGe8CV<6o(14, 29, 84, 87, 92)1Heisemϙ2006Ϛ[ŦņYloVϛǁ4 mm[ ePTFEsšȸGNεϛ6ΈΧǃ [ΦƂʍ\67%U6nϛΥŪ[İŕ\̺ȲƽǜYloʉˏU6oVEpT7o (29)1eNϛKimmϙ2005Ϛ[ŦņYloVϛŵ̢̥ˑĠ̙xY:Aoš ȸ5ƭǃ[ΦƂʍ\ϛ̨Ƌρ̙sĔʕGNŧŀ[74~77%YɓbϛePTFE ̈́\ 39~45%VÞ;QNVEpT7o(41)1Cp\šȸǃY̺˜ąʬ˭̕[ƇʳϛI XrPąʬĤ[ěŀ<ƖX7CV<İŕU̺Ȳ<ƽǜEpoCVsʼGT7o (1, 83)1ƕĸǁÑƣ̺˜U\ϛšȸ̺˜[˪Ȧ<̨Ƨ̺˜YɓbTʺ7CV;mϛ µ¢°xvµYª©<ʓHoCVYln̺ɩ[Çɦ<ʩʓGϛL[ ĖɹYÛ8Ƭɵ˗˭̕[ŭɎYlną̤<̑įGTʉˏYRX<o(57)1C[Υ Ū[İŕVXo̺ȲƽǜXm`Yą̤̑įV782R[ŏϋɽs͍ɜIoNh Y\ϛšȸ̺˜[ąʬĤV̺˜ąa[˯̄èÿ<Ν͆XǀěsȭNIV̋9m pT7o(54)1 SF\IJ1Á˦YrNQTʓʆħƃYǎʕEpT=N(18, 60, 63, 67)1L[ƺƱ V̍ǑϛEmY\ˤVGT[ǡ7jIE;m̀ŀˤVGTƯ?ĔʕEpT=N1. . .
(26) SF\˵[ǜďU6nϛL[ʓßΑŀǑjPET:l`ePTFE<ǯP9X7ʓď͍Ǒ Yĝ9Tϛ̾σY:Aoǧ̺ȲǑ[ϕEj˯̄ƣƃʫYųȽXȼΆsƽǜU= oCVXW;mϛŤʭ˪ȦVGT[Ȣǂ<ιeQT7o1eNϛǧɼʤǑsi RCV;m(4, 16, 52), °µj°¹µUfmpNɼʤĴǎ[Ͷɬ<Ȣǂ Epo1EmYSF\˯̄ͪ[ʇNJsâKiRCV;m(2, 20, 94)ϛ¹wµ VGTãʕGNεϛšȸǃY̨Ƨ˯̄[ͪsêΉIoCViȢǂU=o1 C[l8YSF\ƕĸǁÑƣ̺˜Y:AoΥŪİŕsȽ2Xσ;m͍ɜU=oĻ ̖Ǒs˅hT7o1 CpeU[ʸˌU\SFʗȨ[Ñƣ̺˜VȐƂ˪ȦʗȨ[Ñƣ̺˜[ɓͷ\̻ rpT7o<ϛSF[ŤʭeN\¹wµVGT[͗ç\XEpT7X71 LCUȥ˓U\ϛDžȨ[øŵĸǁ[Ñƣ̺˜VGTƈ̂[6oPETj°µ VɓͷIoCVYlnϛƕĸǁÑƣ̺˜[Ťʭ:l`¹wµVGT[SF [Ǒ̖s͗çGN1. . .
(27) Ȧȋ:l`Ȏɠ 1. Ñƣ̺˜[á̈́ SF eN\ PET Uá̈́EpNŤʭY SF eN\ Gel U¹wµGϛ͐ 4 ˉ ύ[Ñƣ̺˜sá̈́GN1X:ϛ4 ˉύ[Ñƣ̺˜\ ! Ťʭ/¹wµ” [ ƽU̾͒GNϙä9]ŤʭY SF sϛLGT¹wµYi SF sʕ7NÑƣ ̺˜\ “SF/SF” V̾͒GNϚ1Ñƣ̺˜[º·[á̈́:l`L[ʆǑ͘ϒ[Ȏ ɠs×¾Y͒GN1. 1-1. Ťʭ PET ʗȨŤʭ:l` SF ʗȨŤʭ\ϛˁÍ˰˽̪Ⱥ̈́[˽fɄϙHDR16-ELϚ sʕ7T¡²°²U˽epϛ1.5 mm ǁ[Ťʭ<á̈́EpN1SF Ťʭ:l ` PET Ťʭ[ȹȱ\ͪȱŠξƁόljΣϙSEMϚ ϙVE-7800ϛKEYEN CE ʾϛŵΪϚ sʕ7TƈȏGN1Ťʭs 5 5 mm [ŵ=EYĐnĶnϛ}¹§µÂσ¹¢ sʕ7TȂƿIoσ<½YXol8͘ȋļYKN1͘ȋļs͘ȋļ¦²Y ́ʳǃϛCps¹YUřƇGN1EmYʱˍ¨µ¢sͫĠG¹ ŇŗsʱˍʈǙYGN1L[ǃϛÕƛ[ȃáʭsʕ7TÝ̇ϛïʍϛµ. . .
(28) °ϛȔoE:l` {¹}s͟ȉGȂƿs̻QN1. 1-2. ¹wµ 1) SF ¹wµ ¹wµs̻8Nh[ SF ɘɳɩsá̈́GN19M [̩Ĥ±y«ɘɳɩ sánϛˢ˾EpNĿ̅;m[˵ˤYƑGT 20%w/v ėǃYXol8Y̩Ĥ± y«ɘɳɩsĝ9ϛ60$[ǒɭȾ[ÃU 4 ȗΧο̴EKoCVYln˵ˤsɳ ;GN1ɳ;GNɘɳɩsƫɭUĉeGϛȫ̤sʕ7T 3 ȑΧȫs̻QN1 ȫÃ\ɘÏǼsȡVŴY 1 ŔJR͐ 2 Ŕ̻QN1ȫǃϛĿɘɳɩs 4$ϛ18,000 rpmϛ30 ďΧ[ȧØUďμs̻7ϛ¿˨ʆsĶnΰ=ϛ˵ɘɳɩVGN1Cpm Ŀɘɳɩ 1 mL s®¹³YƚΦGTΝEsΟnϛ60$[ǒɭȾUÈʃEKNǃϛ ćƱΝEsΟnϛÈʃė[ΝEVɓͷIoCVUĿ˵ɘɳɩ[ɺƱs˛ĎGN1 C[ɘɳɩ< 5%w/v VXol8Y̲ʝɘsĝ9T͟ȉGN1C[l8YGTá ̈́EpN SF ɘɳɩYŤʭ[Ζď<ƆĀYɧol8YɧɷGN1Ųś[͟ȉY\ ʱˍ¨µ¢sãʕGϛ˧ 100hPa [śĜ¾U SF5%ϙw/vϚɘɳɩY 30 ďΧɧɷ GN1L[ǃϛŤʭsǁ 1.5 mm [ūĤ²¯¹¡Y΄GTć` SF5%ϙw/vϚ. . .
(29) ɘɳɩYɧɷGNʈǙUɩßː˪Y 1 ďΧɧɷGN1Ɇ7Uϛ,80$[ĉċƲY 1 ȗΧρ̇GTɬśGċ˱ÈʃEKN1EmYϛC[ɘɳǑ¹wµs¿ɳ ĤEKoNhϛ70Ϙz¹²ɘɳɩY 10 ďΧɧGN1¹wµEpN SF ¹wµÑƣ̺˜\ϛÈʃGTʺ?Xo[sΫ@NhY̲ʝɘsÿpN y[ÃYÿpϛƎƒì˜GN1ɴ̯\|¹³¹¡U 120$¸20 ďΧ̻7ϛ ɴ̯ǃ\ĉ̳Ʋϙ4$ϚYTì˜GN1 2) °µ¹wµ MediGelatin ϙNippi, JapanϚsϛ̲ʝɘUɺƱ 3%ϙw/vϚY͟ȉGN°µ ɘɳɩY 60$U 4 ȗΧɧɷGN1L[ǃϛŤʭsǁ 1.5 mm [ūĤ²Y΄Gϛ EmY°µɘɳɩÃY 60$U 30 ďΧɧɷGN(25)1ŤʭYÕʳGNàďX °µ¹wµsΰIJIoNhʺͩƬşσẎ=ϛΠƛȷUĝΝGX< mʹ<GϛEmY 4$YìƂGT°µs͛ƔGN1ɆY°µ<Ťʭ;m ę<pX7l8Y 10%²²v²sʕ7TƉɭU 30 ďΧȮɃGϛL[ ǃ²²v²sΰIJIoNh 70%z¹²ɘɳɩY 10 ďΧJR 3 Ŕ ɧɷGN1ȜǃYy[ÃYÿpTƎƒGϛ|¹³¹¡YT 120$ ϙ0.1MPAϚU 20 ďΧɴ̯GN1°µ¹wµGNÑƣ̺˜\Èʃʈ. . .
(30) ǙUì˜GN1. 2. Ñƣ̺˜[͗ç 2-1. |¹³¹¡ɴ̯YloÑƣ̺˜a[ƿυ á̈́EpN 4 ˉύ[Ñƣ̺˜\ϛ|¹³¹¡ɴ̯ėǃUȼΆYűĤ<X 7;ʻ͚IoNhYϛSEM sʕ7T 1-1.VŁȽ[ȎɠUąòσ:l`Ųòσs LpMp͌ƐGN1. 2-2. ¹wµΝΟɓ[ɮƇɠ á̈́GNLpMp[Ñƣ̺˜YÕʳGN¹wµ[ΝΟ\ϛFuhua m ϙ2008Ϛ[ȎɠYlnɮƇGN(32)110 mm [ΤEYĐnĎGN¹wµė [ŤʭVϛ¹wµs̻7΄ƫÈʃEKN6V[Ťʭ[ΝEsϛξƁŶˆ ϙAUX120ϛơɤ̈́áǞϚYT 0.1 mg [ˢƱUɮƇGϛ×¾[ƶ;mΝΟɓs ˛ĎGN1.
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(35) 2-3. ʆǑ͘ϒ šȸƈϒYú˒QT in vitro YTšȸ̺˜[Ņŀìǯ͘ϒ:l`ś́͘ϒsƈ ȏGN1 1) Ņŀìǯ͘ϒ Ņŀìǯ͘ϒ\ƕŠī½͘ϒɄϙEZ-graphϛơɤ̈́áǞϛÐΗϚsʕ7T̻Q N1Ñƣ̺˜s 20 mm [ΤEYĐnϛ˔;m 1 mm [ŧǞY 7-0 ˤs;Aϛˤ [ΤE< 2 cm YXol8YĴƑ[Ȍ˔sDztUřƇGϛ100N [ĜUɑď 3 mm JRƷ=μGTÑƣ̺˜<ʹǾGNȗɽU͐ɮsˮÉGϛʹǾȗɽU͆GNĜ ϙNϚs͐ɮGNϙFigure 1Ϛ 1X:ϛ͐ɮY\°µ«YΓtO 20 mm [Ñƣ̺ ˜s 6 ȥʕ7N1 2) ś́ƻǑʍ͘ϒ ś́ƻǑʍ͘ϒ\ƕŠī½͘ϒɄϙEZ-graphϛơɤ̈́áǞϛÐΗϚsʕ7T̻ QN1Ñƣ̺˜s 10 mm [ΤEYĐnϛL[ŲǁsɮƇGN1Cpsś́ļ[ ½Ẏ͓Gϛ½Ζś́́̇<Ñƣ̺˜½ΖY͎poeU¾έEKN1C[V= ͘ϒɄă[ͯμ\Ñƣ̺˜[ŲǁVXo1L[ǃϛ´¹² 5NϛɮƇ΅Ʊ 2 mm/min VGTϛąǁ[ 25%eUś́GNε[͘ϒĜϙN/mm2Ϛsś́ƻǑʍV. . !.
(36) GNϙFigure 2Ϛ1X:ϛ͐ɮY\°µ«YΓtO 20 mm [Ñƣ̺˜s 6 ȥʕ 7N1. 3. Ñƣ̺˜[šhͽf 3-1. å͘Ġʆ 48 ω[ Sprague-DawleyϙSDϚ°ϛκϛßΝ 200-300g YϛSF/SFϛPET/SFϛ SF/GelϛPET/Gel [͐ 4 ˉύ[Ñƣ̺˜sšȸGN1ãʕGNIbT[°\ ȩÐͻƣŵƃ3ƈϒĠʆǰΡij`Ġʆƈϒ[ǠƷ=4YŤS7Tϐ̒ϛƈϒȃ ásƈȏGNϙǣ͚ʞľϠ23-84Ϛ1. 3-2. šȸȎɠ 48 ω[°YƑGTϛSF/SFϛSF/GelϛPET/SFϛPET/Gel [ϟˉύ[Ñƣ̺ ˜ϙΤE 10 mmϛąǁ 1.5 mmϚs̡ΖŵĠ̙YšȸGN14 ˉύ[Ñƣ̺˜s LpMp 12 ωYšȸGϛšȸ 2 ΈΧǃY 6 ω;mϛEmYšȸ 3 ·ȝǃY 6 ω ;mĶnĎGN1šȸYεGTϛ¥µ²¹²ϙ«¥µ²ϛĂ˒ ̶̈́ϛȩÐϚ50 mg/kg s̡̝ąYɢƓGNǃϛǠ̼ļYřƇGϛĐΦΖU6o. . ".
(37) ̡Ζ[ɔs̚ɔ±¹«ϙ¶w¹ΰɔ±¹« HSϛVeetϛȩÐϚsYTΰɔ GN1̼Ã[͌ƐY\¼ʲ¹«ƶ˒ßόljΣϙEMZ-8TRϛ¬ẍ́ϛ ťʎϚsʕ7N1̚ɔǃϛ̡ΖɉÃĐΦYTΦ̡Gϛ̡ΖŵĠ̙sπĎGN1 100 IU/kg [£±µϙ£±µ±y«ɢƓɩϛƏŰ̶̈́ƣȺϛȩÐϚsƗ ρ̙;mǦÀǃϛ̡ΖŵĠ̙Y±¢ϙ̺˜Ɉ̺ʕ±¢w¨± ¢ϛ¤v¹¬wϛȩÐϚśʳGT̺ɦsΒȌGN1L[ǃϛΒȌΖÝ sĐȌGϛ10 mm [Ñƣ̺˜<šȸĻ̖XΤEsʻìGNǃϛ9-0 w°¬ µx´µˤϙϕƱĭŔãʕx´µˤÕ̀ŀˤϙȣɴ̯ϚJMDN ¹ 38847000ϛNo.8ϛ¤v¹¬wϛȩÐϚsʕ7Tʅò 8-10 Ρ[ĭ˨˱˝̀ ŀYlo˔2ŅŀsƈȏGN1eNϛ̀ŀY6NQT\ϛΡsÑƣ̺˜Y΄G NεY˔YcRp<X7;W8;sʮ͊YT͗çGN1̀ŀ<ˮÉGNǃϛƗ ò[±¢sŲGTÑƣ̺˜ą[ˍɗ<ǨANCVsʻ͚GT;mωò[ ±¢[ΒȌs͍ΰGN1Ñƣ̺˜lniƗòΖY̺ɦ<6oCVsʻ͚GN ǃϛ̡Ůsĭ˨˱ˬYTΥ̡Gϛʬ̣sƫɠV:nỲŀGN1X:ϛ̺ɦ[ ΒȌ:l`ϖΙƔÿ;mΥ̡eU[ȗΧsLpMp͐ɮGN1. . .
(38) 3-3 šȸ̺˜[z¹ȹȱ šȸǃ[Ñƣ̺˜[z¹ȹȱ\ϛͬτɡʛö͕Ȍ́̇ϙProsound -10ϛȑ ˒v´}¬w}²ϛȩÐϚsʕ7Tx ²°µ[ńÿϖΙ¾UƈȏGN1 ¢´¹¡\ 7.5-MHz [±vŠϙξƁ±vǸ͎Ɓ JMDN ¹ 40768000ϛȑ ˒v´}¬w}²ϛȩÐϚsʕ7N1B ¹sʕ7T̺˜ąΖY̺ȲXW [ȼΆ½[ʟƫ[Ȟɾϛ}°¹¢°ϙe-flowϚsʕ7TΦƂǑϛ²¢° ɠsʕ7T̺ɦ΅:l`ǬĠs͟bN1̺˜z¹ȹȱ\ϛšȸǃϜȑϛšɎ ǃϜΈΧϛĶnĎGʯėϙ2 ΈΧeN\ 3 ·ȝϚ[͐ 3 ŔƈȏGN1. 4. šȸ̺˜[˯̄ƃʫ͗ç 4-1. Ñƣ̺˜[ĶnĎGϛģšϛ̵Đ:l`ȯ̭ ĿšȸȢΧ˰ǃϛÑƣ̺˜šȸȗVŁȽ[ϖΙč̇s°YȏGϛɁγ ̤sĐnΦ7T͊Ξsʻìϛǃŵρ̙sĐȌGNǃϛʯPY 0.9%ʓʑϏūɘϙȑ ȥ̶ƙȎʓʑϏūɩϛǢȴ̶ŌƣȺϛŵΪϚ50 ml sϛ18Gϛ16 mm Τ[Ρϙɢ ƓΡ 18G×5/8ϛNIPROϛŵΪϚsʕ7TƤNjƉ;mɢÿGTɻɦGN1L[ǃϛ Ñƣ̺˜sŇŗ˯̄;mďμGTȀĎGN1ȀĎGNÑƣ̺˜\ 99.5%¬¹. . .
(39) ²ϙ̶͘¬¹²ϛΨȩĤƃϛȩÐϚU 1 ȘřƇǃϛÃŹΖ 3 mm sɁȌσU ĐnĎGN1C[˯̄ʅsćƱ 99.5%¬¹²Y 30 ďΧɧɷGT̚ɘGNǃϛ ³µϙ̶͘³µϛΨȩĤƃϛȩÐϚY 90 ďΧɧɷGϛ° wµϙ ¢³¢ 568ϛŋû˨̶ƣȺϛŵΪϚģšsƈȏGN1ģšGN µ¢²\ 6 μm Y̵ĐG˯̄ȿȥsá̈́GN1á̈́GN° wµĐʅYƫɠYDž7£© ±µ¸z|µϙHEϚȯ̭ϛ©µ¸±´¹«ϙMTCϚȯ̭sȏ GN1. 4-2. ˯̄ƃʫȹȱ HE ȯ̭ȿȥU\ϛÑƣ̺˜a[ɼʤǑ˭̕[ɧɸ[ȽƁXW˯̄Āß[ȼΆ s͗çGN1MTC ȯ̭ȿȥU\Ñƣ̺˜Ňŗ:l`Ñƣ̺˜ąa[̦İ˼˷[ Õʳjèÿ[ˈƱs͗çGN1ýʡ˯̄Ĥƃʫȯ̭Y\ϛºɆǧßVGT̺˜ ąʬ˭̕[ȹĎY\ factor)ϙDAKO ʾ̈́ϛDenmarkϚs 50 ïƩΜUϛƬɵ˗ ˭̕[ȹĎY -SMA ©yǧ°´¹²ǧßϙ³xx| x zµʾ̈́ϛȩÐϚs 50 ïƩΜUʕ7T 4$U 1 Șxµ¯¤¹GN1Ɇ7 Uǧ©y IgG |µÕ=ÌɆǧßϙ³xx| xzµʾ̈́ϛȩÐϚ. . .
(40) Y 30 ďΧxµ¯¤¹ǃϛvª¤µµɳɩϙ³xx| xz µʾ̈́ϛȩÐϚsʕ7Tʩ̭EKN1 HE ȯ̭ȿȥsʕ7TĿȹßY:Ao©´ u¹ϛ±µʐ¸ƽͩ˭̕: l`ŻÃʐ[Ďʏ[ˈƱs 0-3 U͗çGN1EmYϛ˼˷̮˭̕[ĎʏƱŀ7i ŁȽY 0-3 U͗çGN1eNϛ¹wµɺƱYlo¹wµ[ɍƂ[ˈ ƱϛeNϛą̤̑į[İŕVXoȍʓą̤[ƽǜ:l`Ƭɵ˗˭̕ƽǜ[ˈƱ sLpMp 0-3 U͗çGN1X:ϛĿφʮ[͗çŤɲ\ƂŜGX7ŧŀs 0, Ͷ Ʊs 1, ÃˈƱs 2, ΝƱs 3 VGNϙTable 1Ϛ1 ɼʤǑ˭̕ϛ¹wµɍƂΟ:l`ȍʓą̤[ƽǜ[͗ç˱ȭ\ϛ4 ˉύ [̺˜Y:7T Mann Whitney test sʕ7Tšȸ 2 ΈΧǃVšȸ 3 ·ȝǃVUɓ ͷGN1eNϛ2 ΈΧ:l` 3 ·ȝY:AoLpMp[͗çφʮs 4 ˉύ[Ñƣ ̺˜U Kruskal-Wallis test sʕ7TɓͷGN1Cpm[¹͍ȫY\ GraphPad PrismϙVersion 5.0aϛz«¹z ϛȩÐϚsʕ7N1˴͐ƃʫȞǖƦɘɲ\ 5% VGN1͐ɮȈð\ƬŞð±ȿɲñƦUʼGN1. . .
(41) 4-3. ʛö͍ȫ ûƃόljΣϙBZ-9000ϛ¹zµϛŵΪϚU HE ȯ̭ȿȥV MTC ȯ̭ȿȥ s͌ƐGϛǿEpT7oʛö͍ȫ (BZ-& Dynamic Cell Count Ver. 1.01, ¹zµ, ŵΪ)sʕ7T˯̄èÿʍVąʬĤʍs͐ɮGN1 1) ˯̄èÿʍ Ñƣ̺˜σˊ[ɮƇY\ϛMTC ȯ̭ȿȥsʕ7N1Ñƣ̺˜σˊ\¹w µƜV° Ɯ[ΖďYrATϛ° ą[̦İ˼˷σˊsɮƇIoV ViYϛÑƣ̺˜σˊV[ɓʍs˛ĎG˯̄èÿʍVGNϙFigure 3Ϛ 1X:ϛ˛ ĎY6NQT\Ŀîß 3 Ȭ[˯̄ȿȥs°µ«YΓǩGϛLpm[ƬŞðs iQTĿîß[˯̄èÿʍVGN1 2) ąʬĤʍ Ñƣ̺˜[ɁȌσY:7T̺˜ąʬ˭̕<ąƹnGT7ąòσ[ΤE[ŀ͐ s͐ɮGϛÑƣ̺˜ąòσ[ĀΤV[ɓʍs˛ĎGTąʬĤʍVGN1 ˯̄èÿʍ:l`ąʬĤʍ[˴͐ƃʫXɓͷ\ϛone-way ANOVA V Bonferroni ɠYlnƈȏGN1Cpm[¹͍ȫY\ GraphPad PrismϙVersion 5.0aϛz«¹z ϛȩÐϚsʕ7N1˴͐ƃʫȞǖƦɘɲ\ 5%VGN1͐ɮ. . .
(42) Ȉð\ƬŞð±ȿɲñƦUʼGN1. . .
(43) ˱ȭ 1. Ñƣ̺˜[͗ç 1-1. SEM YloÑƣ̺˜[͌Ɛ SEM YlQTϛ¹wµė[ SF ŤʭV PET Ťʭ[ąòσ:l`Ųòσ [ʛösdžNϙFigure 4Ϛ 1SF ŤʭV PET ŤʭV[ΧYŵ=XΏ7\ʻ͚EpJϛ WPmi¡²°²˽fEpT7oCV<ʻ͚EpN1eNϛ¹wµ s̻QT7X7Nh˼˷Χ[Χδ<ȔʴYʻ͚EpN1 |¹³¹¡ėǃ[Ñƣ̺˜s SEM YT͌ƐGNϙFigure 5Ϛ 1¹wµ s̻QNCVUŤʭ[fU͌ƐEpN˼˷Χ[Χδ\ɬƖGϛɵm;X̾σ <ʻ͚EpN1G;GϛSF/SF :l` PET/SF [ºΖďU\_`ěp<͚hmp N<ϛCpm[_`ěp\ŃɘʈǙU\͚hmpX;QN1eNϛIbT[Ñ ƣ̺˜Y:7T|¹³¹¡[ėǃUŵ=XΏ7\͚hmpX;QN1. 1-2. ¹wµΝΟɓ LpMp[˯ŀKY:Ao¹wµ[ΝΟɓs Table 2 YʼGN1¹ wµΝΟɓ\ SF/SF :l` PET/SFϛIXrP SF ¹wµsʕ7Nŧŀ. . .
(44) Yŵ=?ŭĝGT7N1ºȎϛ°µ¹wµsʕ7NεY\ŭĝ[ˈ Ʊ\ͶNJU6QN1X:ϛC[¹wµΝΟɓ[ɓͷY:7TϛSF/SF V SF/GelϛSF/SF V PET/GelϛPET/SF V PET/Gel [ΧYȞǖƦ<͚hmpN1. 1-3. ʆǑ͘ϒ 1) Ņŀìǯ͘ϒ Ņŀìǯ͘ϒ[˱ȭ\×¾[V:nU6QNϠSF/SF 5.40.57 N, PET/SF 4.9 0.48 N, SF/Gel 5.80.76 N, PET/Gel 5.30.51 N1X:ϛ4 ˉύ[Ñƣ̺˜[Χ UȞǖƦ\͚hmpX;QNϙFigure 6 ϙAϚϚ1 2) ś́ƻǑʍ ś́ƻǑʍ\×¾[V:nU6QNϠSF/SF 0.0620.014 N/mm2, PET/SF 0.052 0.010 N/mm2, SF/Gel 0.00.006 N/mm2, PET/Gel 0.0140.004 N/mm21SF/SF V SF/Gelϙ Ϛ:l` PET/Gelϙ ϚV[ΧYȞǖƦ<͚hmpNϙFigure 6 ϙBϚϚ1. . .
(45) 3. šȸ̺˜[ʣʑƃʫ͗ç 3-1. ˯̄ƃʫȹȱ šȸ 2 ΈΧǃU\Ñƣ̺˜ŇŗYų?[±µʐVƽͩ˭̕ʐ<ɧɸGT7 N1L[ąòϛRen¹wµΖďY\©´ u¹Vųȳƥ˭̕<ų ?͚hmpN1EmYŤʭ[˼˷[ŇŗYi©´ u¹<ƂŜGT7N1 eNϛŻÃʐ[ɧɸifmpN<Ô[ɼʤǑ˭̕VɓͷGTƖX;QN1˼˷ ̮˭̕\Ñƣ̺˜[ŇŗYɧɸ¸ŭɎGT:nϛºȎϛÑƣ̺˜[ąΖY\c VtW͈7OEpX;QN1eNϛ̃˭X˼˷Ǒ˱ŀ˯̄<̦İ˼˷ẎǼE pT7o[<ʻ͚EpNϙFigure 8Ϛ1šȸ 3 ·ȝǃU\ϛÑƣ̺˜Ňŗ[±µ ʐVƽͩ˭̕\ɬƖGT7N1eNϛŁȽY©´ u¹iɬƖGT7N1 ŻÃʐYR7T\ 2 ΈΧVŵ=XűĤ\X?ƂŜGT7N1˼˷̮˭̕[ȈY ŵ=XűĤ\X7i[[ϛ2 ΈΧVɓͷGTÑƣ̺˜[ąΖYių?͚hmpN1 ̺˜ąʬ˭̕\ PET/Gel ×ŲUÑƣ̺˜[ą̤s͇QT7N1eNϛ̺˜ąʬ ˭̕[¾ƜY\Ƭɵ˗˭̕Ɯ<ƽǜEpT7NϙFigure 9Ϛ1 ×¾Y 4 ˉύ[Ñƣ̺˜YΨIoɼʤǑ˭̕ϛ¹wµɍΟ:l`ȍʓą ̤[įE[ĩƇΟʫ͗ç[˱ȭsʼIϙTable 4Ϛ1. . !.
(46) 1) ©´ u¹ šȸ 2 ΈΧǃΈΧ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.7±0.47; PET/SF, 1.8±0.37; SF/Gel, 1.8±0.37; PET/Gel, 2.0±0.58ϙFigure 10Ϛ1šȸ 3 ·ȝǃ·ȝU[ ˱ȭ\×¾[V:nU6QNϠSF/SF, 1.2±0.37; PET/SF, 1.5±0.50; SF/Gel, 1.5±0.50; PET/Gel, 1.2±0.37ϙFigure 11Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tš ȸ 2 ΈΧǃV 3 ·ȝǃsɓͷIoVϛPTE/Gel YȞǖƦ<͚hmpNϙpϢ0.05ϡ Figure 12Ϛ 1 2) ±µʐ¸ƽͩ˭̕ šȸ 2 ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.8±0.37; PET/SF, 2.5±0.50; SF/Gel, 1.8±0.37; PET/Gel, 2.2±0.37ϙFigure 10Ϛ1šȸ 3 ·ȝǃ[˱ȭ\ ×¾[V:nU6QNϠSF/SF, 1.5±0.50; PET/SF, 2.5±0.50; SF/Gel, 2.0±0.58; PET/Gel, 1.7±0.47ϙFigure 11Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ 2 ΈΧ ǃV 3 ·ȝǃV[ΧYȞǖƦ\͚hmpX;QNϙFigure 13Ϛ1 3) ˼˷̮˭̕ šȸ 2 ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.8±0.37; PET/SF, 2.5±0.50; SF/Gel, 1.3±0.47; PET/Gel, 2.2±0.69ϙFigure 10Ϛ1šȸ 3 ·ȝǃ[˱ȭ\. . ".
(47) ×¾[V:nU6QNϠ SF/SF, 2.2±0.69; PET/SF, 1.8±0.69; SF/Gel, 1.3±0.47; PET/Gel, 1.5±0.50ϙFigure 11Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ 2 ΈΧ ǃV 3 ·ȝǃV[ΧYȞǖƦ\͚hmpX;QNϙFigure 14Ϛ1 4) ŻÃʐ šȸ 2 ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.2±0.37; PET/SF, 1.2±0.37; SF/Gel, 1.3±0.47; PET/Gel, 1.2±0.37ϙFigure 10Ϛ1šȸ 3 ·ȝǃ[˱ȭ\ ×¾[V:nU6QNϠ SF/SF, 0.83±0.37; PET/SF, 1.2±0.37; SF/Gel, 1.2±0.37; PET/Gel, 1.2±0.371X:ϛPET/SF V SF/SFϙpϢ0.01Ϛ, SF/GELϙpϢ0.05Ϛ:l ` SF/GelϙpϢ0.05Ϛ[ΧYȞǖƦ<͚hmpNϙFigure 11Ϛ1ºȎϛLpMp[ Ñƣ̺˜Y:7Tšȸ 2 ΈΧǃV 3 ·ȝǃV[ΧYȞǖƦ\͚hmpX;QN ϙFigure 15Ϛ1 5) ¹wµɍΟ šȸ 2 ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 2.2±0.37; PET/SF, 1.3±0.47; SF/Gel, 0.67±0.47; PET/Gel 1.3±0.471SF/SF V SF/GEL [ΧYȞǖƦ<͚ hmpNϙpϢ0.05ϡ Figure 10Ϛ1šȸ 3 ·ȝǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 0.83±0.37; PET/SF, 1.3±0.47; SF/Gel, 0.67±0.75; PET/Gel, 1.2±0.69ϙFigure. . .
(48) 11Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ 2 ΈΧǃV 3 ·ȝǃsɓͷIoVϛ SF/SF YȞǖƦ<͚hmpNϙpϢ0.01ϚϙFigure 16Ϛ1 6) ȍʓą̤[įE šȸ 2 ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.0±0.58; PET/SF, 0.33±0.47; SF/Gel, 1.7±0.47; PET/Gel, 1.7±0.37ϙFigure 10Ϛ1šȸ 3 ·ȝǃ[˱ȭ\ ×¾[V:nU6QNϠ SF/SF, 0.83±0.37; PET/SF, 1.8±0.90; SF/Gel, 1.7±0.47; PET/Gel, 0.83±0.69ϙFigure 11Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ 2 ΈΧ ǃV 3 ·ȝǃV[ΧYȞǖƦ\͚hmpX;QNϙFigure 17Ϛ1 7) Ƭɵ˗˭̕ šȸ 2 ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.2±0.69; PET/SF, 0.50±0.76; SF/Gel, 1.0±0.58; PET/Gel, 0.17±0.37ϙFigure 10Ϛ1šȸ 3 ·ȝǃ[˱ȭ \×¾[V:nU6QNϠSF/SF, 2.3±0.47; PET/SF, 1.8±0.90; SF/Gel, 1.7±0.47, PET/Gel 0.83±0.691X:ϛSF/SF V PET/SF [ΧYȞǖƦ<͚hmpNϙpϢ0.05ϡ Figure 11Ϛ 1LpMp[Ñƣ̺˜Y:7Tšȸ 2 ΈΧǃV 3 ·ȝǃsɓͷIoVϛ SF/SFϙpϢ0.05Ϛ, PET/SFϙpϢ0.05Ϛ:l` SF/GelϙpϢ0.01ϚYȞǖƦ<͚h mpNϙFigure 18Ϛ1. . .
(49) ʛö͍ȫ 1) ˯̄èÿʍ šȸ 2 ΈΧǃ[˯̄èÿʍ\×¾[V:nU6QNϠSF/SF, 2.81.1 %; PET/SF, 1.20.8 %; SF/Gel, 1.50.9 %; PET/Gel, 1.20.3 %1X:ϛ4 ˉύ[Ñƣ̺˜[Χ YȞǖƦ\͚hmpX;QN1ºȎϛšȸ 3 ·ȝǃ[˯̄èÿʍ\×¾[V: nU6QNϠSF/SF, 17.03.1 %; PET/SF, 17.62.0 %; SF/Gel, 14.12.5 %; PET/Gel, 6.92.0 %1SF/SF V SF/Gelϙ Ϛϛ PET/SF V PET/GelϙϚ V[ΧYȞǖƦ<͚hmpNϙFigure 19 ϙAϚϚ1 2) ąʬĤʍ šȸ 3 ·ȝǃ[ąʬĤʍ\×¾[V:nU6QNϠ SF/SF, 98.23.6 %; PET/SF, 99.41.1 %; SF/Gel, 96.32.8 %; PET/Gel, 51.314.0 %1SF/SF V SF/Gel ϙϚ, PET/SF V PET/GelϙϚV[ΧYȞǖƦ<͚hmpNϙFigure 19 ϙBϚϚ1. . .
(50) ̋Ɛ. ƕĸǁÑƣ̺˜šȸǃ[̺ȲƽǜϛɼʤĴǎ:l`ą̤̑į\ąòσΥŪ[ İŕVXo(86)1šȸ̺˜[˯̄Ĵǎsǥ9ΦƂǑsìǯIoNhYϛȽ2X˪ ȦjȼΆ[Ñƣ̺˜<ΦʩEpT=N(8, 36, 51, 77, 78)1ŵ¸ÃĸǁÑƣ̺˜U ʏŜº̫ʫYãʕEpT7o ePTFE :l` PET \ϛƕĸǁÑƣ̺˜U\ŵ¸Ã ĸǁÑƣ̺˜VɓͷGT̬ŻXΦƂ˱ȭsʼGT7X7(39, 42)1šȸ̺˜YƑ IoʟʆĴǎϛąʬ˭̕[¿ͮYlo̺Ȳƽǜϛ̨Ƨ̺˜V[ʆǑʫXΏ7Y ͫŕIoą̤̑įXW<ʩʓGjI7<ϛC8GNŏϋ\ʓď͍Ǒ[˪Ȧsʕ 7oCVŲƧ˯̄Ẏ=Ǽ9oCVYlnǥ9mpoĻ̖Ǒ<6o(5, 32, 64, 90, 93)1LCUȥ˓U\ϛʓď͍Ǒ:l`ʓßΑŀǑsϕ7CV<Ȕm;VXQ T7o SF sƕĸǁÑƣ̺˜[˪ȦVGTʕ7N1 á̈́GNÑƣ̺˜sšɎIoėYʆǑʫ͗çs̻QN1C[ʆǑʫ͗ç\ in vivo U[͗çYΑGNÑƣ̺˜U6o;W8s͗çIo89UςƫYΝ͆U6 o1ŅŀΖ[ƺƱ\Ñƣ̺˜sšȸIoε[̀ŀǠǤYƿυsÀ9oNhϛL [͗ç\njχU6o1eNϛÑƣ̺˜<ʺI>oV̨Ƨ̺˜V[µ¢°xv. . .
(51) µ[ƦYln̺ɩYÇɦsʓHϛƕĸǁÑƣ̺˜[ΥŪYRX<oą̤̑į [İŕVXoCV;m(39)ϛś́ƺƱ[͗çinj͆U6o1ŅŀƺƱ͘ϒU\ 4 ˉύ[Ñƣ̺˜YȞǖXƦ\ʻ͚EpX;QN1CpYĝ9TϛšȸƈϒY: AòŀǠǤ[εYÑƣ̺˜[˔<cRpNnϛʺI>TΡ<΄mX7V7Q Nŏϋiʻ͚EpX;QN1Cpm[˱ȭ;mϛȥ˓Uʕ7NŤʭ[á̈́Ȏɠ :l`¹wµȎɠ\Ñƣ̺˜[á̈́YȞʕU6oCV<Ȕm;YXQN1 ś́͘ϒU\ʟXQNŤʭYŁH¹wµsȏGN<ϛLpm[ΧYȞǖ Ʀ\͚hmpX;QN1C[CV;m SF Ťʭ\ȐƂ[ PET ŤʭVɓbTΐ̭[ X7ʆǑʫʇǑsȞGT7oCV<ʼEpN1ºȎϛŁHŤʭYʟXQN¹ wµsȏGNÑƣ̺˜[ɓͷU\ϛ°µ¹wµ\ SF ¹wµ lniȞǖYÞ7ðsʼGN1º̫Yś́͘ϒ[˱ȭ\Þ7Ȏ<ȰͳǑY÷ pT7oV̋9mpT7o1C[CV;mȥ˓Uʕ7N°µ¹wµ ɠ\Ñƣ̺˜[á̈́YȞʕU6nϛeN SF ¹wµY:7TišɎȗYʺ I>oϛȃá<ŖνU6oXW[ŏϋi͚hmpX;QNNhϛƕĸǁÑƣ̺ ˜[¹wµVGTΑGT7oV̋9mpN1 ȐƂ[ ePTFE j PET U\˯̄èÿ<ͫCnY?7CV;mϛ˯̄èÿ[͗ç. . .
(52) \ SF [ȞʕǑsʼI89U;XnΝ͆U6o1ȥʸˌY:7TŤʭ[ɓͷs̻ QNεϛSF V PET U\šȸ 2 ΈΧǃU[˯̄èÿʍYƦ\͚hmpX;QN1 G;Gϛšȸ 3 ·ȝǃU SF/Gel V PET/Gel [˯̄èÿʍsɓͷIoVϛSF/Gel [Ȏ<ϕ7ðsʼGN1¹wµ<7Jpi°µU6oCV;mϛC [˯̄èÿʍ[Ʀ\Ťʭ[ƦYloi[U6oV̋9mpϛŤʭU6o SF [ƿ υYln˯̄èÿ<êΉEpNi[V̋9mpN1CpYĝ9Tϛ¹wµ U[ SF V°µ[˯̄èÿʍsɓͷIoVϛšȸ 2 ΈΧǃU\ȞǖXƦ\ ͚hmpX;QN<ϛšȸ 3 ·ȝǃU\ SF <ȞǖYϕ7ðsʼGN1Ťʭ< SF U6o; PET U6o;Y;;rmJϛSF ¹wµsʕ7Nŧŀ\° µ¹wµYɓbT˯̄èÿʍ<ȞǖYϕ;QNCV;mϛCp\ SF ¹wµ<Ñƣ̺˜ąa[˼˷̮˭̕[èÿXm`Y̦İ˼˷[ʔʓsêΉ GNCVYloi[V̋9mpN1 ȥƈϒU\ϛPET/Gel ×Ų[Ñƣ̺˜U\ą̤[ŵΖď<ąʬ˭̕U͇rpT 7N1IJ[Ŧņlnŵ¸ÃĸǁÑƣ̺˜U\˯̄èÿ<ąʬĤsêΉIoC V<Ȕm;VXQT7oCV;m(56)ϛŤʭeN\¹wµY SF sʕ7o CVYlnÑƣ̺˜ąU̦İ˼˷[ʔʓ<êΉEpNCV<̬ŻXąʬĤYR. . .
(53) X<QN[U\X7;V̋9mpN1C[l8Y SF \ŤʭOAUX?¹w µVGTišȸǃ[˼˷̮˭̕[͛ƔXm`Y̦İ˼˷[ʔʓsêΉGϛE mY\ąʬĤYeUiƿυsÀ9T7oCV<Ȕm;YXQN1 C[ SF sŤʭV¹wµ[ÂȎYʕ7N SF/SF U\ϛšȸ 3 ·ȝǃUɼ ʤǑ˭̕[ɬƖ<ʻ͚EpN1PET/Gel Y:7Tišȸ 3 ·ȝǃUɼʤǑ˭̕[ ɬƖ<͚hmpN<ϛL[ąƌ\ SF/SF V\ʟXoi[U6QN1PET/Gel U\ į7̦İ˼˷Ɯ<Ñƣ̺˜[ŲòYƽǜEpϛEmYÑƣ̺˜VC[į7̦İ ˼˷Ɯ[ΧYδΧ<ʻ͚EpN1PET/Gel U\˯̄èÿʍ<Þ;QNCV;mϛ ˯̄ȿȥá̈́ˈY:7TÑƣ̺˜̨ß<Ųò[̦İ˼˷Ɯlniŵ=?ĵ́ GTGeQNCVYͫŕIoi[V̋9mpo1C[CV\ PET/Gel [ʓßΑ ŀǑ<Þ?ϛį7̦İ˼˷Ɯ<Ñƣ̺˜V[ǹ͎sɬƖEKÑƣ̺˜a[ɼʤ Ǒ˭̕[ɡijiɬƖEKNCVYloi[V̋9mpo1×½[CV;mϛŤ ʭV¹wµsɓͷGNεϛ˯̄èÿjɼʤĴǎYŵ=?ƿυsÀ9T7 o[\¹wµU6oV̋9mpN1 º̫Y¹wµ<į7Ȏ<˯̄èÿ\GY?7V̋9mpo<ϛC[˱ ȭ\ SF <˼˷̮˭̕s\HhVIǫƧ˯̄sͪEKoCVYlQT˯̄è. . .
(54) ÿsêΉGT7oCVsʼGT7o1¹wµ[ȥȨ[ʮʫ\šȸǃ[̺ ɩɶpsΫ@CVY6o<ϛȥ˓Uʕ7N SF \C[ȧØsɱNGN½UϛEm Y˯̄èÿsêΉIoCV<ʼEpN1 ȥƈϒU\ϛšȸ 3 ·ȝǃ[ɏβU SF/SF Y:7T SF ̃˷[ºΖ<̨Ƨ˯̄ VGT͚ͣEpϛ˯̄èÿjɼʤĴǎ[͗çOAUX?ϛšȸǃ[̨Ƨ˯̄a [̇Ǽϛ7rko±±µ<ʓHT7oȽƁiʻ͚IoCV<U=N1š ȸǃ[̺˜ąʬ˭̕YloąʬĤs\HhVGTϛą̤̑į[İŕVXmX7 ̵7Ƭɵ˗˭̕Ɯ[ƽǜ\̺ȲƽǜXWΥŪ[İŕsΫ@89UΝ͆U6o(48, 53)1SF sʕ7NÑƣ̺˜U\ąʬĤ\iPqt[CVϛą̤Y\Ƭɵ˗˭̕Ɯ [ƽǜiʻ͚EpN1eNϛÑƣ̺˜ąa[˼˷̮˭̕[ɧɸXm`YCpY ʗȨIo̦İ˼˷[ŭʓiʻ͚Epϛ2 ΈΧVɓͷGT 3 ·ȝY:7T˯̄èÿ ʍ<½ȓGT7N1EmYϛ©´ u¹s\HhVIoɼʤǑ˭̕<ɬƖ GT7NCV;mϛÑƣ̺˜ą[̇Ǽ<Ή̻GT7oi[VfXEpN1 ƕĸǁÑƣ̺˜sΤȢYrNnΦƂEKoY\ϛL[˪ȦYloƿυiΝ͆ U6o<ϛá̈́EpNÑƣ̺˜[Ņŀìǯjś́͘ϒXW[ʆǑʫ͗çiΝ͆ U6o1ȥƈϒUá̈́EpN 4 ˉύ[Ñƣ̺˜U\0Ņŀìǯ͘ϒY:7TȞ. . .
(55) ǖƦ\ʻ͚EpJ, Ņŀ<ŖνVXol8Xƿυi͚hmpX;QN1ºȎUś ́͘ϒ[˱ȭU\ȞǖƦ<ƂŜG0¹wµ[ˉύ<ÅYƿυsÀ9T7 oCV<Ȕm;VXQN1ś́ƻǑʍ<ϕI>oŧŀ\ȰͳǑ<źrp, eNÞ I>oŧŀ\ˇȸǃYÑƣ̺˜[űƽsiNmIĻ̖Ǒ<6o1ȥƈϒYʕ7 N 4 ˉύ[Ñƣ̺˜U\ˇȸǃ:l`ĶnĎGǃYŵ=Xűƽ\ʻ͚EpX; QNCV;mΑɉXð[˞ŗU6QNCVV̋9mpo1C[l8Yϛȥƈϒ Yʕ7NʆǑ͘ϒ\ in vivo [ƈϒs̻8ėYÑƣ̺˜[͗çsIoȎɠVGT ȞʕU6QN1EmYϛȥƈϒU\˯̄èÿʍjąʬĤ[˱ȭ;m SF sŤʭO AUX?ʇY¹wµ[˪ȦVGTʕ7oCV[Ν͆ǑsʼICV<U= N1ȥƈϒU\IbT[Ñƣ̺˜<ΦƂGΥŪä<ƂŜGX;QN1ƕĸǁÑ ƣ̺˜Y:7TΦƂʍ\Ν͆X͗çŤɲU6oNhlnΤȢΧeN\lnΤE [Τ7Ñƣ̺˜sšɎIoCVYlnƕĸǁÑƣ̺˜VGT[͗çs̻8CV inj͆U6oV̋9mpN1. . !.
(56) ƕǮ. ȥ˓U\DžȨ[øŵĸǁ[Ñƣ̺˜VGTƈ̂[6oŤʭ[ PET j¹ wµ[°µV SF sɓͷIoCVYlnϛSF [ƕĸǁÑƣ̺˜[Ťʭ: l`¹wµVGT[ȞʕǑsʼICVsʮʫVGN1SF/SF¸PE/SF¸ SF/G :l` PET/G [͐ 4 ˉύ[Ñƣ̺˜s͐ 48 ĥ[°̡ΖŵĠ̙YšɎ G 2 ΈΧ:l` 3 ·ȝUĶnĎG˯̄ƃʫ͗çVGTšȸ̺˜YƑIoĴǎϛ ˯̄èÿʍ:l`ąʬĤʍs͗çeN͐ɮGN14 ˉύ[Ñƣ̺˜\šɎ 2 ΈΧ :l` 3 ·ȝǃYĶnĎIeUYIbTΦƂGT7N1šȸ 2 ΈΧǃU\Ib T[Ñƣ̺˜UɼʤǑ˭̕<ʻ͚EpN<ϛšȸ 3 ·ȝǃU\ SF/SF :l` PET/G U\ɬƖGT7N1˯̄èÿʍU\šȸ 3 ·ȝǃU\ SF/SF < PET/Gϛ PET/SF < PET/G YɓbTȞǖYϕ;QN1ąʬĤU\ PET/G sΰ=Ô[ 3 ˉ ύ[Ñƣ̺˜ąòσU\cd 100%<ąʬĤEpT7N1Cpm[˱ȭln SF <ŤʭOAUX?¹wµVGTiȐƂ[˪ȦVɓͷGTƕĸǁÑƣ̺˜ YΝ͆U6o˯̄èÿjąʬĤsêΉIoCVsȔm;VGN1EmYŤʭV ¹wµsɓͷGNε, ¹wµ<ln˯̄èÿjąʬĤYƿυsÀ. . ".
(57) 9oCVsȔm;YIoCV<U=N1. . .
(58) Table 1 Ŀφʮ[͗çŤɲsƂŜGX7ŧŀs 0, ͶƱs 1, ÃˈƱs 2, ΝƱs 3 VG0 Table1 YʼGN1 29/01. QJSPHVM. RTO U . . . LVNITK . GD. . EFC. EFC. EFC. EFC. EFC. EFC. !. . . . . . . ". . . . . . . #. . . . . . . . .
(59) Table 2 4 R[Ñƣ̺˜[¹wµYloΝΟɓ †. =P<0.05 SF/SFvsSF/G, ††=P<0.01 SF/SFvsPET/G, *=P<0.05 PET/SFvsPET/G Graft weight before. Graft weight after. Increasing rate of coating. coating (g). coating (g). weight (%). SF/SF. 8.56 ± 0.19. 12.04 ± 0.58. 40.62 ± 5.03†, ††. PET/SF. 10.36 ± 0.89. 14.20 ± 0.98. 37.24 ± 2.94. SF/G. 10.70 ± 2.51. 12.22 ± 2.86. 14.25 ± 4.39. PET/G. 7.91 ± 1.56. 8.77 ± 1.70. 10.76 ± 3.56. . .
(60) Table 3 4 ˉύ[Ñƣ̺˜[šȸ 2 ΈΧǃ:l`šȸ 3 ·ȝǃ[ΦƂä[ěŀ1šȸ 2 ΈΧǃ:l`šȸ 3 ·ȝǃU\IbT[̺˜Y:7TΦƂGT7N1. . . ,) ,). +(- ,). ,) *. +(- *. "<114:. & &. & &. & &. & &. #687;3:. & &. & &. & &. & &. .
(61) Table 4 4 ˉύ[Ñƣ̺˜Y:AoĿȹß[ĩƇΟʫ͗ç[˱ȭs Table 4 YʼGN1. RTO ,) ,). . QJSPHVM. . . LVNITK . GD.
(62) . "<114:. =. ". ". ". !. ". . . >. ". ". ". !. ". !. !. ?. !. ". !. ". ". ". ". @. ". !. ". !. #. !. ". A. !. ". ". !. ". !. !. B. ". ". ". !. ". !. !. =. !. !. ". !. !. ". ". >. !. ". ". !. !. !. ". ?. !. !. #. . . ". #. @. !. !. !. !. !. !. ". A. ". ". ". !. !. ". #. B. !. ". #. !. !. ". ". . . . . . . . . . . . . . . . . . . #687;3:. . .
(63) RTO +(- ,). . QJSPHVM. . . LVNITK . GD.
(64) . "<114:. #687;3:. =. ". #. ". ". ". . . >. ". ". ". !. ". . . ?. ". #. #. !. !. !. !. @. ". ". ". !. !. . . A. !. ". #. !. !. . . B. ". #. #. !. !. !. ". =. ". ". ". !. ". ". ". >. ". #. ". !. ". . . ?. !. ". ". !. !. ". ". @. !. #. #. !. !. #. ". A. ". ". !. ". !. ". #. B. !. #. !. !. !. ". ". . .
(65) RTO ,) *15. QJSPHVM . "<114:. #687;3:. . . LVNITK . GD.
(66) . . =. ". ". !. !. !. !. !. >. !. !. !. ". !. !. !. ?. ". ". ". !. !. !. !. @. ". ". ". !. !. !. !. A. ". ". !. !. . ". ". B. ". ". !. ". . . . =. !. ". ". !. . !. ". >. !. !. !. ". . ". ". ?. ". ". !. !. . ". ". @. ". #. ". !. ". ". ". A. ". ". !. !. !. ". #. B. !. ". !. !. !. !. ". . .
(67) RTO +(- *15. . QJSPHVM. . . LVNITK . GD.
(68) . "<114:. #687;3:. =. #. ". ". !. !. . . >. ". #. #. ". ". . . ?. ". ". #. !. ". . . @. ". ". ". !. !. . . A. ". ". !. !. !. !. !. B. !. ". ". !. !. . . =. !. !. ". !. !. . . >. !. !. ". !. . . . ?. !. ". !. ". !. ". ". @. ". ". !. !. ". !. !. A. !. ". ". !. ". !. !. B. !. ". !. !. !. !. !. . .
(69) Figure 1 Ņŀìǯ͘ϒ[ʛöϙƤϚ:l`ɀƶŘϙĽϚ. . !.
(70) Figure 2 ś́ƻǑʍ͘ϒ[ʛöϙƤϚ:l`ɀƶŘϙĽϚ. . ".
(71)
(72) . Figure 3 ˯̄èÿʍ:l`ą̝ǁ[͐ɮȎɠ. ˯̄èÿʍ[˛ĎY:7T0Ñƣ̺˜σˊ\ graft ƜV¹wµƜϙʵĮąϚ sɮƇG0̦İ˼˷σˊ\Ñƣ̺˜σˊą[̦İ˼˷[σˊsɮƇGN1ą̝ ǁ[ɮƇ\ȜąσU6oą̤Ɯ[ąòϙʵωϚs ±¹µU°µ GTΤEsɮƇGN1ϙ¹²¹Ϡ Ϛ. . .
(73) 外側面. . 内側面. . . .
(74) .
(75) . . . . .
(76) .
(77) . Figure 4 SF Ťʭ:l` PET Ťʭ[ SEM ʛö SF Ťʭ[Ų̾σϙAϚVą̾σϙBϚ Ťʭ[Ų̾σϙCϚVą̾σϙDϚ1. . .
(78) オートクレーブ後. オートクレーブ前. . 外側面. 内側面. 外側面. 内側面. . . . 100 μm. . 100 μm. . 100 μm. . 100 μm. . 100 μm. . 100 μm. . 100 μm. . 100 μm. . . . . 100 μm. . 100 μm. . 100 μm.
(79) . 100 μm. . 100 μm. . 100 μm. . 100 μm. . . Figure 5. 100 μm. 4 ˉύ[Ñƣ̺˜[|¹³¹¡ėǃ[ SEM ʛö. SF ŤʭY SF ¹wµϙA-DϚ, PET ŤʭY SF ¹wµϙE-HϚSF ŤʭY°µ¹wµϙI-LϚ, P ŤʭY°µ¹wµϙM-PϚ1 SF/SF :l` PET/SF [ºΖďU\_`<͚hmpN1IbT[Ñƣ̺˜[| ¹³¹¡ėǃUŵ=XűĤ\͚hmpX;QN1. . .
(80) (A). . 吻合保持試験（N）. 8. 7. 6. 5. 4. . SF/SF. PET/SF. (B). . 圧縮弾性率（N/10%）. . PET/Gel. ★. 0.10. . SF/Gel. ★. 0.08 0.06 0.04 0.02 0.00. SF/SF. PET/SF. SF/Gel. PET/Gel. Figure 6 Ņŀìǯ͘ϒ:l`ś́ƻǑʍ͘ϒ ϙAϚ ˇȸė[4ˉύ[Ñƣ̺˜[Ņŀìǯ͘ϒ1Ȉð<ϕ7cWŅŀΖ[ƺƱ <ƺ7CVsʼGT7o14ˉύ[Ñƣ̺˜YȞǖƦ\͚hmpX;QN1 ϙBϚ ˇȸė[4ˉύ[Ñƣ̺˜[ś́ƻǑʍ͘ϒ1¹wµUɓͷGNε0 SF¹wµVG¹wµ[ΧYȞǖƦ<͚hmpN1ºȎUŁHŤʭs ɓͷGNε0ȞǖƦ\͚hmpX;QNϙ*P < 0.05Ϛ1. . .
(81) Figure 7 šȸGNÑƣ̺˜[z¹ȹȱ Ñƣ̺˜ɁȌσYTƽǙs͌ƐǃϙĈʱ½Ϛ}°¹¢°YT̺ɦsʻ͚G0 ²¢°YTǬĠsʻ͚IoCVUΦƂǑsdžNϙĈʱ¾Ϛ1. . .
(82) .
(83) . . . . . . . . . . . . . . . . .
(84) . .
(85) . Figure 8 šȸ 2 ΈΧǃ[ 4 ˉύ[Ñƣ̺˜ɁȌσ[˯̄ʛö HE ȯ̭SF/SF ϙAϚ, PET/SF ϙCϚ, SF/G ϙEϚ, PET/G ϙGϚ:l` MTC ȯ̭SF/SF ϙBϚ, PET/SF ϙDϚ, SF/G ϙFϚ, PET/G ϙHϚ[˯̄ʛö1SF ¹wµ[ŇŗY\̦İ˼˷<͚hmpN1ºȎU°µ¹wµ[ ŇnY\ʻ͚EpX;QN1ą̝Ɯ[ƽǜ\W[̺˜Y:7Tiʻ͚EpX; QN1 . . .
(86) ⅰ . . . Ⅷ. . . . . . . . . . . . . . . . . . . . . . . . .
(87) . . ⅱ . . Figure 9 šȸ 3 ·ȝǃ[ 4 ˉύ[Ñƣ̺˜ɁȌσ[˯̄ʛö:l` [ǭ ŵŘ ϙ*ϚHEȯ̭SF/SF ϙAϚ, PET/SF ϙDϚ, SF/G ϙGϚ, PET/G ϙJϚ0MTCȯ ̭SF/SF ϙBϚ, PET/SF ϙEϚ, SF/G ϙHϚ, PET/G ϙKϚ:l`factor)SF/SF ϙCϚ, PET/SF ϙFϚ, SF/G ϙIϚ, PET/G ϙLϚYloýʡȯ̭[˯̄ʛö1HE ȯ̭U\SF/SFYį7Ɯ<ąòσY͚hmpN1šȸΈΧǃVɓͷGTɼʤ˭. . .
(88) ̕[ɬƖ<SF/SF:l`PET/GUʻ͚Ep0PET/SF:l`SF/GU\ŵ=?űĤG T7X;QN1PET/G×Ų[̺˜U\˯̄èÿ<͚hmpN1PET/G×Ų[̺˜ U\ąòσY̺˜ąʬ˭̕<͚hmpN1 ϙ+Ϛšȸ3·ȝǃ[SF/SF[Ñƣ̺˜ąΖ[MTCȯ̭ʛösʼGN1ʵĮ\Ť ʭYãʕEpNSF˼˷sʼGT7o1eNʵHn\SF˼˷ΧYèÿGT7o˯ ̄sʼGT7o1. . .
(89) (A). (B) lymphocyte/plasma cell. 4. 4. 3. 3. evaluation. 2 1 0. 2 1. grafts. (D). (C). neutrophil. fibroblast 2.5. 4. 2.0. evaluation. 2 1. 1.5 1.0 0.5. /G el PE T/ G el. T/. /S. /G. SF. grafts. grafts. (E). SF. F. PE T/ G el. PE. SF. T/. el. SF. F /S SF. SF. 0.0. PE. (F). coating amount. neiointimal formation. ★. 2.5. 4. 2.0. evaluation. 3 2 1. 1.5 1.0 0.5. /G el PE T/ G el. T/. /S. F PE. SF. T/. /G el PE T/ G el. SF. F /S. PE. SF. SF. grafts. grafts. (G). SF. 0.0. 0. SF. evaluation. 3. 0. evaluation. /G el PE T/ G el. SF. grafts. SF. F. T/. /S. SF. SF. SF. F. T/. /S. PE. SF. /G el PE T/ G el. 0. PE. evaluation. macrophage. smoooth muscle cell. 2.5. evaluation. 2.0 1.5 1.0 0.5. PE T/ G el. el /G SF. T/ PE. SF. /S. F. SF. 0.0. grafts. Figure 10 šȸ 2 ΈΧǃ[ 4 ˉύ[Ñƣ̺˜Y:Ao˯̄ˀȥ[ĩƇΟʫ͗ç šȸ 2 ΈΧǃ[©´ u¹ϙAϚ 0±µʐ¸ƽͩ˭̕ϙBϚ 0˼˷̮˭̕ϙCϚ0 ŻÃʐϙDϚ0¹wµɍΟϙEϚ0ȍʓą̤[įEϙFϚ0Ƭɵ˗˭̕ϙGϚ [ĩƇΟʫ͗ç1¹wµɍΟY:7T SF/SF V SF/Ge [ΧYȞǖƦ<͚ hmpNϙp<0.05Ϛ1 . !.
(90) (A). (B) macrophage. lymphocyte/plasma cell. 2.5. 4 3. evaluation. 1.5 1.0. 2 1. 0.5 0.0. /G el PE T/ G el. SF. F. SF. T/. /S. SF. SF. SF. F. T/. /S. PE. SF. /G el PE T/ G el. 0. PE. evaluation. 2.0. grafts. grafts. neutrophil. (D). fibroblast. ★ ★★. 4. 4. 3. 3. evaluation. 2 1. ★. 2 1. el PE T/ G el. /G. grafts. grafts. (E). (F) coating amount. neiointimal formation. 4. 4. 3. 3. evaluation. 2 1 0. 2 1. SF. /G el PE T/ G el. SF. SF. grafts. T/. /S. F. el PE T/ G el. /G SF. T/ PE. SF. /S. F. SF. 0. PE. evaluation. SF. F. T/. SF. PE. SF. T/. /S. /G el PE T/ G el. SF. F /S SF. SF. 0. 0. PE. evaluation. (C). grafts. (G) smoooth muscle cell. evaluation. 4. ★. 3 2 1. el PE T/ G el. /G SF. T/ PE. SF. /S. F. SF. 0. grafts. Figure 11 šȸ 3 ·ȝǃ[ 4 ˉύ[Ñƣ̺˜Y:Ao˯̄ˀȥ[ĩƇΟʫ͗ç šȸ ·ȝǃ[©´ u¹ϙAϚ 0±µʐ¸ƽͩ˭̕ϙBϚ 0˼˷̮˭̕ϙCϚ0 ŻÃʐϙDϚ0¹wµɍΟϙEϚ0ȍʓą̤[įEϙFϚ0Ƭɵ˗˭̕ϙGϚ [ĩƇΟʫ͗ç1ŻÃʐY:7T PET/SF V SF/SFϙpϢ0.01Ϛ, SF/GELϙpϢ0.05Ϛ :l` SF/GelϙpϢ0.05Ϛ[ΧYȞǖƦ<͚hmpN1Ƭɵ˗˭̕Y:7T SF/SF V PET/SF [ΧYȞǖƦ<͚hmpNϙpϢ0.05Ϛ1. . ".
(91) (B). SF/SF. 2.5. 2.0. 2.0. evaluation. 2.5. 1.5 1.0. PET/SF. 1.5 1.0 0.5. 0.0. 0.0. implanted period. s th on. implanted period. (C). (D). PTE/Gel. SF/Gel. ★. 2.5. 4. 2.0. 3. evaluation. 1.5 1.0 0.5. 2 1. th on. 2w ee ks. s th on 3m. 2w ee ks. s. 0. 0.0. 3m. evaluation. 3m. 3m. on. th. 2w ee ks. s. 0.5. 2w ee ks. evaluation. (A). implanted period. implanted period. Figure 12 ©´ u¹[ĩƇΟʫ͗ç 4 ˉύ[Ñƣ̺˜SF/SFϙAϚ 0PET/SFϙBϚ 0SF/GelϙCϚ 0PET/GelϙDϚY:7 Tšȸ ΈΧǃV ·ȝǃ[©´ u¹[ĩƇΟʫ͗ç1PTE/Gel Y:7T ȞǖƦ<͚hmpNϙpϢ0.05Ϛ1. . .
(92) (A). (B). SF/SF. PET/SF. 2.5. 3.5 3.0. evaluation. 1.5 1.0. 2.5. 0.5. 2.0. 0.0. 1.5. implanted period. s th on. implanted period. (D). SF/Gel. 4. 4. 3. 3. evaluation. 2 1. 2 1. 3m. implanted period. s th on. on. th. s. 2w ee ks. 0. 2w ee ks. 0. PET/Gel. 3m. evaluation. (C). 3m. 3m. on. th. 2w ee ks. s. 2w ee ks. evaluation. 2.0. implanted period. Figure 13 ±µʐ¸ƽͩ˭̕[ĩƇΟʫ͗ç 4 ˉύ[Ñƣ̺˜SF/SFϙAϚ 0PET/SFϙBϚ 0SF/GelϙCϚ 0PET/GelϙDϚY:7 Tšȸ 2 ΈΧǃV 3 ·ȝǃ[±µʐ¸ƽͩ˭̕[ĩƇΟʫ͗ç1ȞǖƦ\͚ hmpX;QN1. . .
(93) (B). SF/SF. 4. 4. 3. 3. evaluation. 2 1. 2 1. implanted period. s th on. implanted period. (D). SF/Gel. 4. 4. 3. 3. evaluation. 2 1. 2 1. 3m. on. implanted period. s th. th. s. 2w ee ks. 0 2w ee ks. 0. PET/Gel. on. evaluation. (C). 3m. 3m. on. th. s. 2w ee ks. 0 2w ee ks. 0. PET/SF. 3m. evaluation. (A). implanted period.
(94) ˼˷̮˭̕[ĩƇΟʫ͗ç ˉύ[Ñƣ̺˜ ϙϚ0 ϙϚ0
(95) ϙϚ0
(96) ϙϚY:7T šȸ ΈΧǃV ·ȝǃ[˼˷̮˭̕[ĩƇΟʫ͗ç1ȞǖƦ\͚hmpX; QN1. . .
(97) (B) 2.5. 2.0. 2.0. 1.0 0.5. 0.0. 0.0 3m. on. th. s. 2w ee ks. 0.5. implanted period. implanted period. (D) 2.5. 2.0. 2.0. 1.0 0.5. 0.0. 0.0. 3m. on. th. s. 2w ee ks. 0.5. implanted period. s. 1.0. 1.5. th. 1.5. on. evaluation. 2.5. PET/Gel. 3m. SF/Gel. 2w ee ks. evaluation. (C). s. 1.0. 1.5. th. 1.5. on. evaluation. 2.5. PET/SF. 3m. SF/SF. 2w ee ks. evaluation. (A). implanted period. Figure 15 ŻÃʐ[ĩƇΟʫ͗ç 4 ˉύ[Ñƣ̺˜[SF/SFϙAϚ 0PET/SFϙBϚ 0SF/GelϙCϚ 0PET/GelϙDϚ]Y:7 Tšȸ 2 ΈΧǃV 3 ·ȝǃ[ŻÃʐ[ĩƇΟʫ͗ç1ȞǖƦ\͚hmpX;Q N1. . .
(98) (A). (B). SF/SF. PET/SF. ★★. 2.5 2.0. 3. evaluation. 2 1. 1.5 1.0 0.5. (D) 2.5. 2.0. 2.0. 1.0. th on. 1.5 1.0 0.5. 0.0. 0.0. 3m. on. th. s. 2w ee ks. 0.5. implanted period. s. 1.5. th. evaluation. 2.5. PET/Gel. on. SF/Gel. 2w ee ks. evaluation. 3m. 2w ee ks. s th on. 2w ee ks. 3m. implanted period. implanted period. (C). s. 0.0. 0. 3m. evaluation. 4. implanted period. Figure 16 ¹wµɍΟ[ĩƇΟʫ͗ç 4 ˉύ[Ñƣ̺˜[SF/SFϙAϚ 0PET/SFϙBϚ 0SF/GelϙCϚ 0PET/GelϙDϚ]Y:7 Tšȸ 2 ΈΧǃV 3 ·ȝǃ[¹wµɍΟ[ĩƇΟʫ͗ç1SF/SF Y:7T ȞǖƦ<͚hmpNϙpϢ0.01Ϛ1 . . .
(99) (B) 2.5. 2.0. 2.0. 1.0 0.5. 0.0. 0.0 3m. on. th. s. 2w ee ks. 0.5. implanted period. implanted period. (D) 2.5. 2.0. 2.0. 1.0 0.5. 0.0. 0.0. 3m. on. th. s. 2w ee ks. 0.5. implanted period. s. 1.0. 1.5. th. 1.5. on. evaluation. 2.5. PET/Gel. 3m. SF/Gel. 2w ee ks. evaluation. (C). s. 1.0. 1.5. th. 1.5. on. evaluation. 2.5. PET/SF. 3m. SF/SF. 2w ee ks. evaluation. (A). implanted period. Figure 17 ȍʓą̤[įE[ĩƇΟʫ͗ç 4 ˉύ[Ñƣ̺˜[SF/SFϙAϚ 0PET/SFϙBϚ 0SF/GelϙCϚ 0PET/GelϙDϚ]Y:7 Tšȸ 2 ΈΧǃV 3 ·ȝǃ[ȍʓą̤[įE[ĩƇΟʫ͗ç1ȞǖƦ\͚hm pX;QN1. . .
(100) (A). (B). PET/SF. SF/SF ★. 4. evaluation. 3 2 1. 3 2 1 0. 3m. on. th. s. 2w ee ks. 3m. on. th. s. 2w ee ks. 0. grafts. grafts. (C). ★★. 4. PET/Gel. 2.5 2.0. 3. evaluation. 2 1. 1.5 1.0 0.5. 0. th. s. 2w ee ks. 3m. on. th. s. 2w ee ks. 0.0. on. evaluation. (D). SF/Gel. 3m. evaluation. ★. 4. grafts. grafts. Figure 18 Ƭɵ˗˭̕[ĩƇΟʫ͗ç 4 ˉύ[Ñƣ̺˜[SF/SFϙAϚ 0PET/SFϙBϚ 0SF/GelϙCϚ 0PET/GelϙDϚ]Y:7 Tšȸ 2 ΈΧǃV 3 ·ȝǃ[Ƭɵ˗˭̕[ĩƇΟʫ͗ç1SF/SF ϙpϢ0.05Ϛ,PET/SF ϙpϢ0.05Ϛ,SF/GelϙpϢ0.05ϚY:7TȞǖƦ<͚hmpN1. . .
(101) (A) 25. 25. 20. 20. 組織侵入率（%）. 組織侵入率（%）. ★. 15 10. 15 10 5. 5 0. ★★. SF/SF. PET/SF. SF/Gel. 0. PET/Gel. SF/SF. PET/SF. SF/Gel. PET/Gel. 3 months. 2 weeks. (B) ★★ ★★. 100. 内皮化率（％）. 80 60 40 20 0. SF/SF. PET/SF. SF/Gel. PET/Gel. Figure 19 šȸΈΧǃ:l`šȸ ·ȝǃ[˯̄èÿʍVąʬĤʍ ϙAϚšȸ2ΈΧǃ:l`šȸ3·ȝǃ[4ˉύ[Ñƣ̺˜[˯̄èÿʍ1šȸ2 ΈΧǃU\˯̄èÿʍYȞǖƦ\͚hmpX;QN<0šȸ3·ȝǃU\SF/SF VPET/G[ΧYȞǖƦ<͚hmpNϙ*P < 0.05, **P < 0.01Ϛ1ϙBϚšȸ3·ȝǃ [ąʬĤʍ1šȸ3·ȝǃU\SF/SF,PET/SF:l`SF/GUąʬĤ<͚hmpN1 G;GPET/GU\ąʬĤ<ĨďYʻ͚EpJȞǖƦ<͚hmpNϙ**P < 0.01Ϛ1. . .
(102) ˕ 2˓ SF [¹wµɺƱ<ƕĸǁÑƣ̺˜a[˯̄èÿYÀ9oƿυ. ͡͏ IJYá̈́EpNÑƣ̺˜\Ťʭ[fUšȸIoV̺ɩ[ɶĎ<ʓHoNhϛ Ǡ̼ÃY¢³´wµ<̻rpT7N(73)1C[¢³´wµ[ƣ ˈsʰ?NhYϛʏŜ\°µj°¹µϛv²¡ªµYln¹²E pNÑƣ̺˜<ãʕEpϛL[˱ȭϛ̺ɩ[ɶĎsΫ@CV<Ļ̖YXQN(71)1 Cpm[¹wµĘ\šȸǃYDŽ2YɨźGT7?CV<ȠeG7<ϛL [ΧY¹wµĘYƑIoýʡĴǎϛɼʤĴǎϛʩʂXW<Ǔ̌[ͤǫV Xnϛʥf\iPqt[CVÿίȢΧ[ƳΤjǧʓʆͩ[ãʕΟ<ų?Xo[ XW[ŏϋ<ʓHT7o(37)1eNϛ¹wµ\Ñƣ̺˜[ʆǑʫǀěiȭ NGT7o(7, 32, 91)1Ñƣ̺˜[á̈́Y:7T\ϛ¹wµɺƱ<ϕ7V ʺI>TÑƣ̺˜YΡsEI[<νG?XnϛY̵I>oVÑƣ̺˜<cR pTGe7ϛŤʭ[fOVŅŀƺƱsìTX7Nhϛšȸ<ŖνYXo1C[ l8YÑƣ̺˜sá̈́Io½U¹wµ\=rhTΝ͆U6n(79)ϛL[˪ ȦjΟYR7T\ĨďYȹ͑Ionj͆<6o1Ñƣ̺˜[¹wµYΨI. . !.
(103) oʸˌ\ȐY̻rpT7TϛZuhirmϙ2014Ϛ[ŦņU\PET¨±z²[ ¹wµVGTńĵǑ[ŀǜϕďƁs24ä[Ǔ̌YãʕGϛšȸ3·ȝǃU 90.9%ϙ22/24ϚY̬ŻXΦƂsʻ͚GT7o(27)1eNϛBlazermϙ1988Ϛ[Ŧ ņU\ϛ¤´vȼΆsȞIoŤʭY°µ¹wµsȏGNÑƣ̺˜V ¹wµsGX;QNÑƣ̺˜[2ƭǃ[ΦƂʍsɓͷGNVCqϛÂ̌V iΦƂʍ\100%U6QN(12)1G;GϛCpm\7Jpiŵ¸ÃĸǁÑƣ̺˜ U[˱ȭU6o1eNϛƕĸǁÑƣ̺˜U¹wµY£±µsʕ7oƈ ϒiXEpT7o<ϛSF[¹wµYΨIoŦņ\fmpX71 ė˓Y:7TϛSF <ŤʭOAUX?¹wµVGTiȞʕU6oCV< ʼEpN1SF \ʓßΑŀǑ<ϕ7CV;mϛ°µXWUŏϋVXošȸǃ [ɼʤsͶɬU=o[U\X7;V̋9mpo1eNϛEnomoto m[ϙ2010Ϛ ʸˌU\ϛSF s¨µ¹wµVGTʕ7oCVUϛΤȢΧ[ΦƂV grafts ąa[˯̄èÿ<ʻ͚EpT7o(20)1Cp\ƕĸǁÑƣ̺˜YVQTΝ ͆U6ošȸ̺˜ąa[̦İ˼˷sÃNjVIǫƧ˯̄[èÿs SF ¹wµ <êGNi[U6oV̋9mpϛSF [¹wµȦȋVGT[ȞʕǑs͂ ÕAT7o1C[l8Yϛ¹wµ\ɼʤĴǎϛƺƱϛµ±µOA. . ".
(104) UX?ϛ̨Ƨ˯̄a[̇ǼYiŵ=XƿυsÀ9oV̋9mpo1 LCUȥ˓U\ϛ¹wµYʳʮGϛ¹wµ[ SF ɺƱsű9oC VYloÑƣ̺˜[ʆǑʫűĤs in vitro U͗çGN1EmYϛin vivo Y:7T SF ɺƱ[Ώ7<˯̄èÿʍϛą̤̑įXWYÀ9oƿυsɓͷGϛȜΑX SF [¹wµɺƱYR7Tȹ͑GN1. . .
(105) Ȧȋ:l`Ȏɠ 1. Ñƣ̺˜[á̈́ SF Uá̈́EpNŤʭY SF :l` PEGDE [ɫŀɳɩs¹wµGÑƣ̺ ˜sá̈́GN1X:ϛ¹wµYʕ7N SF ɳɩ[ɺƱs 1.0%ϛ 2.5%ϛ 5.0%ϛ 7.5%ϙw/vϚVű9N͐ 4 ˉύ[Ñƣ̺˜sá̈́GN1Ñƣ̺˜[º·[á̈́: l`L[ʆǑ͘ϒ[Ȏɠs×¾Y͒GN1. 1-1. Ťʭ ˕ 1 ˓VŁȽ[ȎɠU¡²°²˽fϛ1.5 mm ǁ[ƕĸǁÑƣ̺˜[Ť ʭsá̈́GN1eNϛͪȱŠξƁόljΣϙSEMϚϙVE-7800ϛKEYEN CE ʾϛŵ ΪϚYlQTϛ˕ 1 ˓VŁȽYĿÑƣ̺˜[ąòσ:l`Ųòσs͌ƐGN1. 1-2. ¹wµ 1.0%ϛ2.5%ϛ5.0%ϛ7.5%ϙw/vϚ[ SF ɳɩYϛLpMpV˖ΝΟ[ polyϙethylene glycolϚ diglycidyl etherϙPEGDEϚsɫŀGTɳɩsá̈́GN(7)(91)1PEGDE sĝ9oCVYln¹wµ<¨µʈ[ȼΆsiRCVU̺˜YȰͳ. . .
(106) ǑsiNmGϛL[Χδ;m[˯̄èÿsĻ̖YIoºȎUϛšȸǃYŏϋV Xo̺ɩɶpsΫ@1EmYϛC[ PEGDE \šȸǃȒȢYď͍EpoCV<Ȕ m;YXQT7o(30)1LpMp[ɺƱ[ɳɩYϛ½[¡²°²˽fY Tá̈́GN SF Ñƣ̺˜Ťʭs 30 ďΧɧɷGϛĀßY޺YȯfͽeKN1C [ŤʭsūĤ²ȷϙǁ 1.5 mmϚY΄GϛŤʭąYˍɗ<ɫÿGX7l8ɬ ś¾ϙ0.01MPaϚẎ=ϛ-20$YTºȘċ˱EKN1L[ǃϛ3 ȑΧɘÃYT ȫ¸͍ċGT PEGDE sĶnΰ=ϛ|¹³¹¡ɴ̯ϙ120$ϛ0.1MPAϛ20 ďΧϚsƈȏGN1PEGDE <ΑĐYΰIJEpT7oCV\ϛÑƣ̺˜ÈʃǃY ATR-FTIRϙFT/IR-4100, JAS COϚsʕ7Tʻ͚GN1. 2. Ñƣ̺˜[ƽǙƃʫ:l`ʆǑʫ͗ç 2-1. Ñƣ̺˜[͌Ɛ ¹wµƆÉǃϛŤʭ[͌ƐVŁȽYͪȱŠξƁόljΣϙSEMϚ ϙVE-7800ϛ KEYENCE ʾϛŵΪϚYlQTϛLpMp[Ñƣ̺˜[ąòσ:l`Ųòσs ͌ƐGN1eNϛ¹wµ[͗çVGTϛ¹wµėǃY:AoĿɺ Ʊ[Ñƣ̺˜[̵ĐʅY HE ȯ̭:l` MT C ȯ̭sȏGN1. . .
(107) 2-2. ¹wµΝΟɓ[ɮƇɠ LpMp[Ñƣ̺˜YÕʳGN¹wµYR7T\ϛ˕ 1 ˓VŁȽ[Ȏ ɠYlnΝΟɓs˛ĎGN1. 2-3. ʆǑ͘ϒ šȸƈϒėY in vitro YTšȸ̺˜[Ņŀǯ͘ϒϛś́͘ϒ:l`ɘ͘ϒs ƈȏGN1 1) Ņŀìǯ͘ϒ Ņŀìǯ͘ϒϙNϚ\˕ 1 ˓VŁȽY̻QN1 2) ś́ƻǑʍ͘ϒ ś́ƻǑʍ͘ϒϙN/mm2Ϛ\˕ 1 ˓VŁȽY̻QN1 3) ɘ͘ϒ šȸǃ[̺ɦćΦYlo̺ɩɶp[ˈƱs͗çIoNhϛɘ͘ϒsʕ7T ɘΟ ml/5cm/min U͗çGN1¥±²w¨µ¢ϙMINIPULS Evolution14595400ϛz«zɄœϚYln 1 ďΧY 60 Ŕ[ǬĠsͫCGTºƇ [΅ƱUɘsLjʒEKϛśµ ¹ϙ̍ʒŬ²śĜµ AP-V80ϛ¹. . .
(108) zµϚYTśĜsɮƇGN1ºƇ[śĜϙ18 kPaϚYXol8Y͟˝GNǃϛ 7 cm [Ñƣ̺˜[ƤĽ 1 cm JRsɄœÝʳGϛÑƣ̺˜;mɶpĎoɘ[Ο sɮƇGNϙFigure 20Ϛ1 3. Ñƣ̺˜[šhͽf 3-1. å͘Ġʆ 48 ω[ Sprague-DawleyϙSDϚ°ϛ¬ϛßΝ 200-300 g YÑƣ̺˜sš ȸGN1ãʕGNIbT[°\ȩÐͻƣŵƃ3ƈϒĠʆǰΡij`Ġʆƈϒ [ǠƷ=4YŤS7Tϐ̒¸˜ʑGϛƈϒȃásƈȏGNϙǣ͚ʞľϠ26-76Ϛ1. 3-2. šȸȎɠ 48 ω[°[̡ΖŵĠ̙Yϛ1.0%ϛ2.5%ϛ5.0%ϛ7.5%[ϟˉύ[Ñƣ̺˜ ϙΤE 10 mmϛąǁ 1.5 mmϚsšȸGN14 ˉύ[Ñƣ̺˜sLpMp 12 ωY šȸGϛšȸ 3 ΈΧǃY 6 ω;mϛEmYšȸ 3 ·ȝǃY 6 ω;mĶnĎGN1 šȸȎɠ\˕ 1 ˓VŁȽU6QN1. 3-3. šȸ̺˜[z¹ȹȱ. . .
(109) šȸǃ[Ñƣ̺˜[z¹ȹȱ\ϛ˕ 1 ˓VŁȽYͬτɡʛö͕Ȍ́̇ ϙProsound -10ϛȑ˒v´}ʾϚsʕ7Tx ²°µ[ńÿϖΙ¾UƈȏG N1̺˜z¹ȹȱ\ϛšȸϜȑǃϛšɎϜΈΧǃϛĶnĎGʯė ϙ3 ΈΧe N 3 ·ȝϚ[͐ 3 ŔƈȏGN1. 4. šȸ̺˜[ƽǙƃʫ͗ç 4-1. Ñƣ̺˜[ĶnĎGϛģšϛ̵Đ:l`ȯ̭ ĿšȸȢΧ˰ǃϛ°YÑƣ̺˜šȸȗVŁȽ[ϖΙč̇sȏGϛ˕ 1 ˓VŁȽ[ȎɠUÑƣ̺˜sĶnĎGϛřƇǃY̵ĐGT˯̄ȿȥsá̈́GN1 ̵ĐʅY\ƫɠYDžQT HE ȯ̭ϛMTC ȯ̭sȏGN1. 4-2. ˯̄ƃʫȹȱ ˕ 1 ˓VŁȽYϛHE ȯ̭ȿȥU\Ñƣ̺˜a[ɼʤǑ˭̕ɧɸsÃNjY˯̄ Āß[ȼΆs͗çGN1eNϛMTC ȯ̭ȿȥU\Ñƣ̺˜Ňŗ:l`Ñƣ̺˜ ąa[̦İ˼˷[Õʳjèÿ[ˈƱs͗çGN1ýʡ˯̄Ĥƃʫȯ̭U\ϛ˕ 1 ˓VŁȽY̺˜ąʬ˭̕[ȹĎY CD31ϛƬɵ˗˭̕[ȹĎY -SMA sʕ7T. . .
(110) DAB Ylnʩ̭EKN1X:ϛɼʤǑ˭̕ϛ¹wµɍƂΟϛȍʓą̤[ ƽǜϛƬɵ˗˭̕[ŭɎYΨIo͗çs˕ 1 ˓VŁȽYLpMp 0-3 U͗çGN1 EmYCpm[¹͍ȫ\˕ 1 ˓VŁȽ[ȎɠU̻QN1. 4-3. ʛö͍ȫ ˕ 1 ˓VŁȽYûƃόljΣϙBZ-9000ϛ¹zµϚU MTC ȯ̭ȿȥs͌Ɛ GϛǿEpT7oʛö͍ȫ sʕ7T˯̄èÿʍVą̝ǁs͐ɮGN1 1) ˯̄èÿʍ ˯̄èÿʍ[˛Ď\˕ 1 ˓VŁȽY̻QN1 2) ą̝ǁ Ñƣ̺˜[ɊfXWYlo͜ƦsȜƕĤIoNhϛÑƣ̺˜ąòσ[ΤEs ĆŇʍϙ ϚUΰIoCVUϛÑƣ̺˜[ą̝ǁs˛ĎGN1ą̝[ĀΤ\ ±¹µYTąòσs°µGTɮƇGN1 3) ˴͐ ˯̄èÿʍ:l`ą̝ǁ[˴͐ƃʫXɓͷ\ϛone-way ANOVA V Bonferroni ɠYŤS7TƈȏGN1Cpm[¹͍ȫY\ GraphPad PrismϙVersion 5.0aϛ. . .
(111) z«¹z Ϛsʕ7N1˴͐ƃʫȞǖƦɘɲ\ 5%VGN1͐ɮð\ƬŞð± ȿɲñƦUʼGN1. . .
(112) ˱ȭ 1. Ñƣ̺˜[ƽǙƃʫ:l`ʆǑʫ͗ç 1-1. SEM YloÑƣ̺˜[͌Ɛ SEM ʛöYlQTdžmpN¹wµė[ŤʭV¹wµǃ[Ñƣ̺ ˜[ąòσVŲòσ[ʛöϙFigure 21ϚU\ϛ¹wµėY\° YΧ δ<ȔʴY͌ƐEpN[YƑGTϛ¹wµǃY\¹wµɺƱ[ŭ ĝYViXQTΧδ<Ɇ˕YƕE?XQNϙFigure 22Ϛ 11.0%V 2.5%YR7T\ ¹wµǃYiąòσYΧδ<fmpϛʇY 1.0%U\ŲòσYi° [˼˷<ʻ͚EpN1ºȎϛ5.0%V 7.5%U\ϛ7JpiŲòσ\¹wµ YlQT͇rpT:nϛąòσYi˼˷Χ[δΧ\cVtW͚hmpX;Q N1. 1-2. HE :l` MTC ȯ̭YloÑƣ̺˜[͌Ɛ ¹wµė[Ťʭ[f[ʈǙU\ϛHE ȯ̭V MTC ȯ̭[7JpY:7 Tių?[Χδ<ʻ͚EpNϙFigure 23Ϛ1ºȎϛ¹wµǃY\ SEM [ ˱ȭVŁȽYΧδ\Ȕm;YƕE?XQT7N1X:ϛÑƣ̺˜[įEY\. . !.
(113) ¹wµ[ˈƱYloΏ7\͚hmpX;QN1. 1-3. ¹wµΝΟɓ ¹wµΟ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 15.35.6 %ϡ 2.5 %, 30.81.0 %ϡ 5.0 %, 40.85.3 %ϡ 7.5 %, 57.31.3 %1X:ϛ1.0 %V 2.5 %ϙ Ϛϛ 5.0 %V 1.0 %ϙϚ:l` 2.5 %ϙ Ϛ ϛ 7.5 %V 1.0 % ϙϚϛ2.5 %ϙϚ:l` 5.0 %ϙϚV[ΧYȞǖƦ <͚hmpNϙFigure 24 ϙAϚϚ 1. 1-4. ʆǑ͘ϒ 1) Ņŀìǯ͘ϒ Ņŀìǯ͘ϒ[˱ȭ\×¾[V:nU6QNϠ 1.0%, 0.640.34 Nϡ 2.5%, 1.0 0.42 Nϡ 5.0%, 3.30.71 %ϡ 7.5%, 4.40.86 N1X:ϛ5.0 %V 1.0 %ϙϚ :l` 2.5 %ϙϚϛ7.5 %V 1.0 %ϙϚϛ2.5 %ϙϚ: l` 5.0 %ϙ ϚV[ΧYȞǖƦ<͚hmpNϙFigure 24 ϙBϚϚ1. . ".
(114) 2) ś́ƻǑʍ ś́ƻǑʍ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 0.00160.00045 N/mm2ϡ 2.5 %, 0.00600.0013 N/mm2ϡ 5.0 %, 9.21.5 N/mm2ϡ 7.5 %, 8.01.7 N/mm21 X:ϛ5.0 %V 1.0 %ϙϚ:l` 2.5 %ϙ Ϛϛ 7.5 %V 1.0 %ϙ Ϛϛ2.5 %ϙϚ:l` 5.0 %ϙϚV[ΧYȞǖƦ<͚h mpNϙFigure 24 ϙCϚϚ1 3) ɘ͘ϒ ɘ͘ϒ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 51.41.1 ml/5cm/minϡ 2.5 %, 48.05.2 ml/5cm/minϡ 5.0 % 36.27.6 ml/5cm/min, 7.5 % 21.69.7 ml/5cm/min1 X:ϛ1.0 %V 5.0 %ϙ Ϛ:l` 7.5 %ϙϚ ϛ 2.5 %V 7.5 %ϙ Ϛϛ5.0 %V 7.5 %ϙ ϚV[ΧYȞǖƦ<͚hmpNϙFigure 24 ϙDϚϚ1. 2. Ñƣ̺˜[šhͽf 2-1. šȸǠǤ:l`šȸȗΧ Ñƣ̺˜[šȸYεGTϛ1.0%[Ñƣ̺˜U\ŅŀȗỲŀΖÝYͶƱXc Rp<fmpNi[[ϛšȸ\Ļ̖U6QN1Ô[¹wµɺƱU\cR p\͚hmpX;QN1eNϛµ´¹²ŖνXĎ̺\W[ɺƱY:7Ti. . !.
(115) ͚hmpJϛ48 ωIbT[°UÑƣ̺˜[šȸ<Ļ̖U6QN14 ˉύ[ Ñƣ̺˜[šɎȗΧYƦ\X?ϛ̺ɦΒȌȗΧ\ 30-45 ďΧU6nϛšȸY;; QNȗΧ\ 45-60 ďU6QN1eNϛ7Jp[°iĶnĎGÊƇȑeUʓƂ Gϛz¹ȹȱ:l`ĶnĎG<Ļ̖U6QN1. 2.2 šȸ̺˜[z¹ȹȱ šȸϜΈΧǃeU\ϛz¹ȹȱYlnIbT[° UΦƂ<ʻ͚Ep N1šȸ 3 ΈΧǃU\ϛ¹wµɺƱ< 2.5 %[̺˜V 7.5 %[̺˜ULp MpϜωJRΥŪGT7N<ϛLp×ŲU\ΦƂ<ʻ͚EpN1eNϛšȸ 3 ·ȝǃ[i[U\ 5.0 %[i[< 1 ωΥŪGT7N1Cpm 3 ω[ΥŪäYR7 T\˯̄èÿʍϛąʬĤϛą̝ǁXW[͗ç;mΰŲGNϙTable 5Ϛ1. 3. šȸ̺˜[̎ʲʫ:l`˯̄ƃʫ͗ç 3.1 ̎ʲʫǞ͈ šȸ 3 ·ȝǃ[ĶnĎGȗY:AoÑƣ̺˜[̎ʲʫȹ˫U\ϛήƙǑǭƹ jŅŀΖY:AoÑƣ̺˜[ʹ̀XW[ʟƫ\͚hmpX;QN1eNϛ¹. . !.
(116) wµɺƱ<Þ7cWÑƣ̺˜[ŇŗYų?[̨Ƨ˯̄<ǹʳGT7N1º Ȏϛ¹wµɺƱ<ϕ7Ñƣ̺˜U\¹wµ<ŇŗYų?ɍQNe eU6nϛ;Rą̤Y\̑į<͚hmpN1¹wµɺƱ<Þ7Ñƣ̺˜ U\ą̤̑į\͌ƐEpX;QN1X:ϛ4 ˉύIbT[Ñƣ̺˜ąòσY̺Ȳ XW[Õʳ\͚hmpX;QNϙFigure 25Ϛ1. 3.2 ˯̄ƃʫȹȱǞ͈ šȸ 3 ΈΧǃU\ 4 ˉύ[Ñƣ̺˜Yų?[±µʐVƽͩ˭̕<ɧɸGT 7N1L[ąòϛRen¹wµΖďY\©´ u¹Vųȳƥ˭̕< ų?͚hmpN1C[¹wµYR7T\ 5.0%V 7.5%Uų?ɍƂGT7N1 ŤʭsȼǜIo˼˷[ŇŗYi©´ u¹<ɧɸGT7N1eNϛŻÃʐ [ɧɸi͚hmpN<ϛÔ[ɼʤǑ˭̕VɓͷGTL[Ȉ\ƖX;QN11.0% V 2.5%U\˼˷̮˭̕<Ñƣ̺˜[ŮąYiʻ͚EpN<ϛºȎU 5.0%V 7.5% U\ų?<Ñƣ̺˜[ŇŗYɧɸ¸ŭɎGT7NϙFigure 26Ϛ1 šȸ 3 ·ȝǃU\Ñƣ̺˜Ňŗ[±µʐVƽͩ˭̕\ɬƖGT7N<ϛĀ ß[ΟVGT\šȸϞΈΧǃVŵ=XΏ7\X;QN1eNϛ©´ u¹. . !.
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