šȸ2ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.2±0.37; PET/SF, 1.2±0.37; SF/Gel, 1.3±0.47; PET/Gel, 1.2±0.37ϙFigure 10Ϛ1šȸ3·ȝǃ[˱ȭ\
×¾[V:nU6QNϠ SF/SF, 0.83±0.37; PET/SF, 1.2±0.37; SF/Gel, 1.2±0.37;
PET/Gel, 1.2±0.371X:ϛPET/SFVSF/SFϙpϢ0.01Ϛ, SF/GELϙpϢ0.05Ϛ:l
`SF/GelϙpϢ0.05Ϛ[ΧYȞǖƦ<͚hmpNϙFigure 11Ϛ1ºȎϛLpMp[
Ñƣ̺˜Y:7Tšȸ2ΈΧǃV3·ȝǃV[ΧYȞǖƦ\͚hmpX;QN ϙFigure 15Ϛ1
5) ¹wµɍΟ
šȸ2ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 2.2±0.37; PET/SF, 1.3±0.47; SF/Gel, 0.67±0.47; PET/Gel 1.3±0.471SF/SFVSF/GEL[ΧYȞǖƦ<͚
hmpNϙpϢ0.05ϡ Figure 10Ϛ1šȸ3·ȝǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 0.83±0.37; PET/SF, 1.3±0.47; SF/Gel, 0.67±0.75; PET/Gel, 1.2±0.69ϙFigure
11Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ2ΈΧǃV3·ȝǃsɓͷIoVϛ SF/SFYȞǖƦ<͚hmpNϙpϢ0.01ϚϙFigure 16Ϛ1
6) ȍʓą̤[įE
šȸ2ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.0±0.58; PET/SF, 0.33±0.47; SF/Gel, 1.7±0.47; PET/Gel, 1.7±0.37ϙFigure 10Ϛ1šȸ3·ȝǃ[˱ȭ\
×¾[V:nU6QNϠ SF/SF, 0.83±0.37; PET/SF, 1.8±0.90; SF/Gel, 1.7±0.47;
PET/Gel, 0.83±0.69ϙFigure 11Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ2ΈΧ ǃV3·ȝǃV[ΧYȞǖƦ\͚hmpX;QNϙFigure 17Ϛ1
7) Ƭɵ˗˭̕
šȸ2ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ SF/SF, 1.2±0.69; PET/SF, 0.50±0.76; SF/Gel, 1.0±0.58; PET/Gel, 0.17±0.37ϙFigure 10Ϛ1šȸ3·ȝǃ[˱ȭ
\×¾[V:nU6QNϠSF/SF, 2.3±0.47; PET/SF, 1.8±0.90; SF/Gel, 1.7±0.47, PET/Gel 0.83±0.691X:ϛSF/SFVPET/SF[ΧYȞǖƦ<͚hmpNϙpϢ0.05ϡ
Figure 11Ϛ1LpMp[Ñƣ̺˜Y:7Tšȸ2ΈΧǃV3·ȝǃsɓͷIoVϛ
SF/SFϙpϢ0.05Ϛ, PET/SFϙpϢ0.05Ϛ:l`SF/GelϙpϢ0.01ϚYȞǖƦ<͚h mpNϙFigure 18Ϛ1
ʛö͍ȫ
1) ˯̄èÿʍ
šȸ2ΈΧǃ[˯̄èÿʍ\×¾[V:nU6QNϠSF/SF, 2.81.1 %; PET/SF, 1.20.8 %; SF/Gel, 1.50.9 %; PET/Gel, 1.20.3 %1X:ϛ4ˉύ[Ñƣ̺˜[Χ YȞǖƦ\͚hmpX;QN1ºȎϛšȸ3·ȝǃ[˯̄èÿʍ\×¾[V:
nU6QNϠSF/SF, 17.03.1 %; PET/SF, 17.62.0 %; SF/Gel, 14.12.5 %;
PET/Gel, 6.92.0 %1SF/SFVSF/GelϙϚϛ PET/SFVPET/GelϙϚ V[ΧYȞǖƦ<͚hmpNϙFigure 19 ϙAϚϚ1
2) ąʬĤʍ
šȸ3·ȝǃ[ąʬĤʍ\×¾[V:nU6QNϠ SF/SF, 98.23.6 %;
PET/SF, 99.41.1 %; SF/Gel, 96.32.8 %; PET/Gel, 51.314.0 %1 SF/SFVSF/Gel ϙϚ, PET/SFVPET/GelϙϚV[ΧYȞǖƦ<͚hmpNϙFigure 19 ϙBϚϚ1
̋Ɛ
ƕĸǁÑƣ̺˜šȸǃ[̺ȲƽǜϛɼʤĴǎ:l`ą̤̑į\ąòσΥŪ[
İŕVXo(86)1šȸ̺˜[˯̄Ĵǎsǥ9ΦƂǑsìǯIoNhYϛȽ2X˪
ȦjȼΆ[Ñƣ̺˜<ΦʩEpT=N(8, 36, 51, 77, 78)1ŵ¸ÃĸǁÑƣ̺˜U
ʏŜº̫ʫYãʕEpT7oePTFE:l`PET\ϛƕĸǁÑƣ̺˜U\ŵ¸Ã ĸǁÑƣ̺˜VɓͷGT̬ŻXΦƂ˱ȭsʼGT7X7(39, 42)1šȸ̺˜YƑ IoʟʆĴǎϛąʬ˭̕[¿ͮYlo̺Ȳƽǜϛ̨Ƨ̺˜V[ʆǑʫXΏ7Y
ͫŕIoą̤̑įXW<ʩʓGjI7<ϛC8GNŏϋ\ʓď͍Ǒ[˪Ȧsʕ
7oCVŲƧ˯̄Ẏ=Ǽ9oCVYlnǥ9mpoĻ̖Ǒ<6o(5, 32, 64,
90, 93)1LCUȥ˓U\ϛʓď͍Ǒ:l`ʓßΑŀǑsϕ7CV<Ȕm;VXQ
T7oSFsƕĸǁÑƣ̺˜[˪ȦVGTʕ7N1
á̈́GNÑƣ̺˜sšɎIoėYʆǑʫ͗çs̻QN1C[ʆǑʫ͗ç\in
vivoU[͗çYΑGNÑƣ̺˜U6o;W8s͗çIo89UςƫYΝ͆U6
o1ŅŀΖ[ƺƱ\Ñƣ̺˜sšȸIoε[̀ŀǠǤYƿυsÀ9oNhϛL
[͗ç\njχU6o1eNϛÑƣ̺˜<ʺI>oV̨Ƨ̺˜V[µ¢°xv
µ[ƦYln̺ɩYÇɦsʓHϛƕĸǁÑƣ̺˜[ΥŪYRX<oą̤̑į
[İŕVXoCV;m(39)ϛś́ƺƱ[͗çinj͆U6o1ŅŀƺƱ͘ϒU\4 ˉύ[Ñƣ̺˜YȞǖXƦ\ʻ͚EpX;QN1CpYĝ9TϛšȸƈϒY:
AòŀǠǤ[εYÑƣ̺˜[˔<cRpNnϛʺI>TΡ<΄mX7V7Q
Nŏϋiʻ͚EpX;QN1Cpm[˱ȭ;mϛȥ˓Uʕ7NŤʭ[á̈́Ȏɠ
:l`¹wµȎɠ\Ñƣ̺˜[á̈́YȞʕU6oCV<Ȕm;YXQN1
ś́͘ϒU\ʟXQNŤʭYŁH¹wµsȏGN<ϛLpm[ΧYȞǖ
Ʀ\͚hmpX;QN1C[CV;mSFŤʭ\ȐƂ[PETŤʭVɓbTΐ̭[
X7ʆǑʫʇǑsȞGT7oCV<ʼEpN1ºȎϛŁHŤʭYʟXQN¹
wµsȏGNÑƣ̺˜[ɓͷU\ϛ°µ¹wµ\SF¹wµ
lniȞǖYÞ7ðsʼGN1º̫Yś́͘ϒ[˱ȭ\Þ7Ȏ<ȰͳǑY÷
pT7oV̋9mpT7o1C[CV;mȥ˓Uʕ7N°µ¹wµ
ɠ\Ñƣ̺˜[á̈́YȞʕU6nϛeNSF¹wµY:7TišɎȗYʺ I>oϛȃá<ŖνU6oXW[ŏϋi͚hmpX;QNNhϛƕĸǁÑƣ̺
˜[¹wµVGTΑGT7oV̋9mpN1
ȐƂ[ePTFEjPETU\˯̄èÿ<ͫCnY?7CV;mϛ˯̄èÿ[͗ç
\SF[ȞʕǑsʼI89U;XnΝ͆U6o1ȥʸˌY:7TŤʭ[ɓͷs̻
QNεϛSFVPETU\šȸ2ΈΧǃU[˯̄èÿʍYƦ\͚hmpX;QN1 G;Gϛšȸ3·ȝǃUSF/GelVPET/Gel[˯̄èÿʍsɓͷIoVϛSF/Gel [Ȏ<ϕ7ðsʼGN1¹wµ<7Jpi°µU6oCV;mϛC
[˯̄èÿʍ[Ʀ\Ťʭ[ƦYloi[U6oV̋9mpϛŤʭU6oSF[ƿ υYln˯̄èÿ<êΉEpNi[V̋9mpN1CpYĝ9Tϛ¹wµ
U[SFV°µ[˯̄èÿʍsɓͷIoVϛšȸ2ΈΧǃU\ȞǖXƦ\
͚hmpX;QN<ϛšȸ3·ȝǃU\SF<ȞǖYϕ7ðsʼGN1Ťʭ<
SFU6o;PETU6o;Y;;rmJϛSF¹wµsʕ7Nŧŀ\°
µ¹wµYɓbT˯̄èÿʍ<ȞǖYϕ;QNCV;mϛCp\SF
¹wµ<Ñƣ̺˜ąa[˼˷̮˭̕[èÿXm`Y̦İ˼˷[ʔʓsêΉ
GNCVYloi[V̋9mpN1
ȥƈϒU\ϛPET/Gel×Ų[Ñƣ̺˜U\ą̤[ŵΖď<ąʬ˭̕U͇rpT 7N1IJ[Ŧņlnŵ¸ÃĸǁÑƣ̺˜U\˯̄èÿ<ąʬĤsêΉIoC
V<Ȕm;VXQT7oCV;m(56)ϛŤʭeN\¹wµYSFsʕ7o CVYlnÑƣ̺˜ąU̦İ˼˷[ʔʓ<êΉEpNCV<̬ŻXąʬĤYR
X<QN[U\X7;V̋9mpN1C[l8YSF\ŤʭOAUX?¹w µVGTišȸǃ[˼˷̮˭̕[͛ƔXm`Y̦İ˼˷[ʔʓsêΉGϛE
mY\ąʬĤYeUiƿυsÀ9T7oCV<Ȕm;YXQN1
C[SFsŤʭV¹wµ[ÂȎYʕ7NSF/SFU\ϛšȸ3·ȝǃUɼ ʤǑ˭̕[ɬƖ<ʻ͚EpN1PET/GelY:7Tišȸ3·ȝǃUɼʤǑ˭̕[
ɬƖ<͚hmpN<ϛL[ąƌ\SF/SFV\ʟXoi[U6QN1PET/GelU\
į7̦İ˼˷Ɯ<Ñƣ̺˜[ŲòYƽǜEpϛEmYÑƣ̺˜VC[į7̦İ
˼˷Ɯ[ΧYδΧ<ʻ͚EpN1PET/GelU\˯̄èÿʍ<Þ;QNCV;mϛ
˯̄ȿȥá̈́ˈY:7TÑƣ̺˜̨ß<Ųò[̦İ˼˷Ɯlniŵ=?ĵ́
GTGeQNCVYͫŕIoi[V̋9mpo1C[CV\PET/Gel[ʓßΑ ŀǑ<Þ?ϛį7̦İ˼˷Ɯ<Ñƣ̺˜V[ǹ͎sɬƖEKÑƣ̺˜a[ɼʤ
Ǒ˭̕[ɡijiɬƖEKNCVYloi[V̋9mpo1×½[CV;mϛŤ
ʭV¹wµsɓͷGNεϛ˯̄èÿjɼʤĴǎYŵ=?ƿυsÀ9T7
o[\¹wµU6oV̋9mpN1
º̫Y¹wµ<į7Ȏ<˯̄èÿ\GY?7V̋9mpo<ϛC[˱
ȭ\SF<˼˷̮˭̕s\HhVIǫƧ˯̄sͪEKoCVYlQT˯̄è
ÿsêΉGT7oCVsʼGT7o1¹wµ[ȥȨ[ʮʫ\šȸǃ[̺
ɩɶpsΫ@CVY6o<ϛȥ˓Uʕ7NSF\C[ȧØsɱNGN½UϛEm Y˯̄èÿsêΉIoCV<ʼEpN1
ȥƈϒU\ϛšȸ3·ȝǃ[ɏβUSF/SFY:7TSF̃˷[ºΖ<̨Ƨ˯̄
VGT͚ͣEpϛ˯̄èÿjɼʤĴǎ[͗çOAUX?ϛšȸǃ[̨Ƨ˯̄a
[̇Ǽϛ7rko±±µ<ʓHT7oȽƁiʻ͚IoCV<U=N1š
ȸǃ[̺˜ąʬ˭̕YloąʬĤs\HhVGTϛą̤̑į[İŕVXmX7
̵7Ƭɵ˗˭̕Ɯ[ƽǜ\̺ȲƽǜXWΥŪ[İŕsΫ@89UΝ͆U6o(48,
53)1SFsʕ7NÑƣ̺˜U\ąʬĤ\iPqt[CVϛą̤Y\Ƭɵ˗˭̕Ɯ [ƽǜiʻ͚EpN1eNϛÑƣ̺˜ąa[˼˷̮˭̕[ɧɸXm`YCpY
ʗȨIo̦İ˼˷[ŭʓiʻ͚Epϛ2ΈΧVɓͷGT3·ȝY:7T˯̄èÿ ʍ<½ȓGT7N1EmYϛ©´ u¹s\HhVIoɼʤǑ˭̕<ɬƖ
GT7NCV;mϛÑƣ̺˜ą[̇Ǽ<Ή̻GT7oi[VfXEpN1
ƕĸǁÑƣ̺˜sΤȢYrNnΦƂEKoY\ϛL[˪ȦYloƿυiΝ͆
U6o<ϛá̈́EpNÑƣ̺˜[Ņŀìǯjś́͘ϒXW[ʆǑʫ͗çiΝ͆
U6o1ȥƈϒUá̈́EpN4ˉύ[Ñƣ̺˜U\0Ņŀìǯ͘ϒY:7TȞ
!
ǖƦ\ʻ͚EpJ, Ņŀ<ŖνVXol8Xƿυi͚hmpX;QN1ºȎUś
́͘ϒ[˱ȭU\ȞǖƦ<ƂŜG0¹wµ[ˉύ<ÅYƿυsÀ9T7
oCV<Ȕm;VXQN1ś́ƻǑʍ<ϕI>oŧŀ\ȰͳǑ<źrp, eNÞ I>oŧŀ\ˇȸǃYÑƣ̺˜[űƽsiNmIĻ̖Ǒ<6o1ȥƈϒYʕ7
N4ˉύ[Ñƣ̺˜U\ˇȸǃ:l`ĶnĎGǃYŵ=Xűƽ\ʻ͚EpX;
QNCV;mΑɉXð[˞ŗU6QNCVV̋9mpo1C[l8Yϛȥƈϒ
Yʕ7NʆǑ͘ϒ\in vivo[ƈϒs̻8ėYÑƣ̺˜[͗çsIoȎɠVGT
ȞʕU6QN1EmYϛȥƈϒU\˯̄èÿʍjąʬĤ[˱ȭ;mSFsŤʭO AUX?ʇY¹wµ[˪ȦVGTʕ7oCV[Ν͆ǑsʼICV<U=
N1ȥƈϒU\IbT[Ñƣ̺˜<ΦƂGΥŪä<ƂŜGX;QN1ƕĸǁÑ
ƣ̺˜Y:7TΦƂʍ\Ν͆X͗çŤɲU6oNhlnΤȢΧeN\lnΤE
[Τ7Ñƣ̺˜sšɎIoCVYlnƕĸǁÑƣ̺˜VGT[͗çs̻8CV
inj͆U6oV̋9mpN1
"
ƕǮ
ȥ˓U\DžȨ[øŵĸǁ[Ñƣ̺˜VGTƈ̂[6oŤʭ[PETj¹
wµ[°µVSFsɓͷIoCVYlnϛSF[ƕĸǁÑƣ̺˜[Ťʭ:
l`¹wµVGT[ȞʕǑsʼICVsʮʫVGN1SF/SF¸PE/SF¸
SF/G:l`PET/G[͐4ˉύ[Ñƣ̺˜s͐48ĥ[°̡ΖŵĠ̙YšɎ
G2ΈΧ:l`3·ȝUĶnĎG˯̄ƃʫ͗çVGTšȸ̺˜YƑIoĴǎϛ
˯̄èÿʍ:l`ąʬĤʍs͗çeN͐ɮGN14ˉύ[Ñƣ̺˜\šɎ2ΈΧ :l`3·ȝǃYĶnĎIeUYIbTΦƂGT7N1šȸ2ΈΧǃU\Ib T[Ñƣ̺˜UɼʤǑ˭̕<ʻ͚EpN<ϛšȸ3·ȝǃU\SF/SF:l`
PET/GU\ɬƖGT7N1˯̄èÿʍU\šȸ3·ȝǃU\SF/SF<PET/Gϛ PET/SF<PET/GYɓbTȞǖYϕ;QN1ąʬĤU\PET/Gsΰ=Ô[3ˉ ύ[Ñƣ̺˜ąòσU\cd100%<ąʬĤEpT7N1Cpm[˱ȭlnSF
<ŤʭOAUX?¹wµVGTiȐƂ[˪ȦVɓͷGTƕĸǁÑƣ̺˜
YΝ͆U6o˯̄èÿjąʬĤsêΉIoCVsȔm;VGN1EmYŤʭV
¹wµsɓͷGNε, ¹wµ<ln˯̄èÿjąʬĤYƿυsÀ
9oCVsȔm;YIoCV<U=N1
Table 1
Ŀφʮ[͗çŤɲsƂŜGX7ŧŀs0, ͶƱs1, ÃˈƱs2, ΝƱs3VG0
Table1YʼGN1
29/01 QJSPHVM RTOU LVNITK GD EFC EFC EFC EFC EFC EFC
!
"
#
Table 2
4R[Ñƣ̺˜[¹wµYloΝΟɓ
†=P<0.05 SF/SFvsSF/G, ††=P<0.01 SF/SFvsPET/G, *=P<0.05 PET/SFvsPET/G Graft weight before
coating (g)
Graft weight after coating (g)
Increasing rate of coating weight (%)
SF/SF 8.56 ± 0.19 12.04 ± 0.58 40.62 ± 5.03†, ††
PET/SF 10.36 ± 0.89 14.20 ± 0.98 37.24 ± 2.94 SF/G 10.70 ± 2.51 12.22 ± 2.86 14.25 ± 4.39 PET/G 7.91 ± 1.56 8.77 ± 1.70 10.76 ± 3.56
Table 3
4ˉύ[Ñƣ̺˜[šȸ2ΈΧǃ:l`šȸ3·ȝǃ[ΦƂä[ěŀ1šȸ2 ΈΧǃ:l`šȸ3·ȝǃU\IbT[̺˜Y:7TΦƂGT7N1
,),) +(-,) ,)* +(-*
"<114: && && && &&
#687;3: && && && &&
Table 4
4ˉύ[Ñƣ̺˜Y:AoĿȹß[ĩƇΟʫ͗ç[˱ȭsTable 4YʼGN1
,),) QJSPHVM
RTO
LVNITK GD
"<114: = " " " ! "
> " " " ! " ! !
? ! " ! " " " "
@ " ! " ! # ! "
A ! " " ! " ! !
B " " " ! " ! !
#687;3: = ! ! " ! ! " "
> ! " " ! ! ! "
? ! ! # " #
@ ! ! ! ! ! ! "
A " " " ! ! " #
B ! " # ! ! " "
+(-,) QJSPHVM
RTO
LVNITK GD
"<114: = " # " " "
> " " " ! "
? " # # ! ! ! !
@ " " " ! !
A ! " # ! !
B " # # ! ! ! "
#687;3: = " " " ! " " "
> " # " ! "
? ! " " ! ! " "
@ ! # # ! ! # "
A " " ! " ! " #
B ! # ! ! ! " "
,)*15
QJSPHVM
RTO
LVNITK GD
"<114: = " " ! ! ! ! !
> ! ! ! " ! ! !
? " " " ! ! ! !
@ " " " ! ! ! !
A " " ! ! " "
B " " ! "
#687;3: = ! " " ! ! "
> ! ! ! " " "
? " " ! ! " "
@ " # " ! " " "
A " " ! ! ! " #
B ! " ! ! ! ! "
+(-*15 QJSPHVM
RTO
LVNITK GD
"<114: = # " " ! !
> " # # " "
? " " # ! "
@ " " " ! !
A " " ! ! ! ! !
B ! " " ! !
#687;3: = ! ! " ! !
> ! ! " !
? ! " ! " ! " "
@ " " ! ! " ! !
A ! " " ! " ! !
B ! " ! ! ! ! !
!
Figure 1 Ņŀìǯ͘ϒ[ʛöϙƤϚ:l`ɀƶŘϙĽϚ
"
Figure 2 ś́ƻǑʍ͘ϒ[ʛöϙƤϚ:l`ɀƶŘϙĽϚ
Figure 3 ˯̄èÿʍ:l`ą̝ǁ[͐ɮȎɠ
˯̄èÿʍ[˛ĎY:7T0Ñƣ̺˜σˊ\graftƜV¹wµƜϙʵĮąϚ sɮƇG0̦İ˼˷σˊ\Ñƣ̺˜σˊą[̦İ˼˷[σˊsɮƇGN1ą̝
ǁ[ɮƇ\ȜąσU6oą̤Ɯ[ąòϙʵωϚs ±¹µU°µ
GTΤEsɮƇGN1ϙ¹²¹ϠϚ
Figure 4 SFŤʭ:l`PETŤʭ[SEMʛö
SFŤʭ[Ų̾σϙAϚVą̾σϙBϚ Ťʭ[Ų̾σϙCϚVą̾σϙDϚ1
外側面 内側面
Figure 5 4ˉύ[Ñƣ̺˜[|¹³¹¡ėǃ[SEMʛö
SFŤʭYSF¹wµϙA-DϚ, PETŤʭYSF¹wµϙE-HϚSF ŤʭY°µ¹wµϙI-LϚ, PŤʭY°µ¹wµϙM-PϚ1
SF/SF:l` PET/SF[ºΖďU\_`<͚hmpN1IbT[Ñƣ̺˜[|
¹³¹¡ėǃUŵ=XűĤ\͚hmpX;QN1
オートクレーブ前 オートクレーブ後
100 μm
100 μm
100 μm 100 μm
100 μm
100 μm 100 μm
100 μm 100 μm
100 μm
100 μm 100 μm
100 μm 100 μm 100 μm 100 μm
内側面
外側面 外側面 内側面
Figure 6 Ņŀìǯ͘ϒ:l`ś́ƻǑʍ͘ϒ
ϙAϚ ˇȸė[4ˉύ[Ñƣ̺˜[Ņŀìǯ͘ϒ1Ȉð<ϕ7cWŅŀΖ[ƺƱ
<ƺ7CVsʼGT7o14ˉύ[Ñƣ̺˜YȞǖƦ\͚hmpX;QN1 ϙBϚˇȸė[4ˉύ[Ñƣ̺˜[ś́ƻǑʍ͘ϒ1¹wµUɓͷGNε0 SF¹wµVG¹wµ[ΧYȞǖƦ<͚hmpN1ºȎUŁHŤʭs ɓͷGNε0ȞǖƦ\͚hmpX;QNϙ*P < 0.05Ϛ1
SF/SF PET/SF SF/Gel PET/Gel 4
5 6 7 8
吻合保持試験（N）
SF/SF PET/SF SF/Gel PET/Gel 0.00
0.02 0.04 0.06 0.08 0.10
★
★
圧縮弾性率（N/10%）
(A)
(B)
Figure 7 šȸGNÑƣ̺˜[z¹ȹȱ
Ñƣ̺˜ɁȌσYTƽǙs͌ƐǃϙĈʱ½Ϛ}°¹¢°YT̺ɦsʻ͚G0
²¢°YTǬĠsʻ͚IoCVUΦƂǑsdžNϙĈʱ¾Ϛ1
Figure 8 šȸ2ΈΧǃ[4ˉύ[Ñƣ̺˜ɁȌσ[˯̄ʛö
HEȯ̭SF/SF ϙAϚ, PET/SF ϙCϚ, SF/G ϙEϚ, PET/G ϙGϚ:l`MTC ȯ̭SF/SF ϙBϚ, PET/SF ϙDϚ, SF/G ϙFϚ, PET/G ϙHϚ[˯̄ʛö1SF
¹wµ[ŇŗY\̦İ˼˷<͚hmpN1ºȎU°µ¹wµ[
ŇnY\ʻ͚EpX;QN1ą̝Ɯ[ƽǜ\W[̺˜Y:7Tiʻ͚EpX;
QN1
Figure 9 šȸ3·ȝǃ[4ˉύ[Ñƣ̺˜ɁȌσ[˯̄ʛö:l`[ǭ
ŵŘ
ϙ*ϚHEȯ̭SF/SF ϙAϚ, PET/SF ϙDϚ, SF/G ϙGϚ, PET/G ϙJϚ0MTCȯ
̭SF/SF ϙBϚ, PET/SF ϙEϚ, SF/G ϙHϚ, PET/G ϙKϚ:l`factor)SF/SF ϙCϚ, PET/SF ϙFϚ, SF/G ϙIϚ, PET/G ϙLϚYloýʡȯ̭[˯̄ʛö1HE ȯ̭U\SF/SFYį7Ɯ<ąòσY͚hmpN1šȸΈΧǃVɓͷGTɼʤ˭
Ⅷ
ⅰ
ⅱ
̕[ɬƖ<SF/SF:l`PET/GUʻ͚Ep0PET/SF:l`SF/GU\ŵ=?űĤG T7X;QN1PET/G×Ų[̺˜U\˯̄èÿ<͚hmpN1PET/G×Ų[̺˜
U\ąòσY̺˜ąʬ˭̕<͚hmpN1
ϙ+Ϛšȸ3·ȝǃ[SF/SF[Ñƣ̺˜ąΖ[MTCȯ̭ʛösʼGN1ʵĮ\Ť ʭYãʕEpNSF˼˷sʼGT7o1eNʵHn\SF˼˷ΧYèÿGT7o˯
̄sʼGT7o1
!
Figure 10 šȸ2ΈΧǃ[4ˉύ[Ñƣ̺˜Y:Ao˯̄ˀȥ[ĩƇΟʫ͗ç
šȸ2ΈΧǃ[©´ u¹ϙAϚ0±µʐ¸ƽͩ˭̕ϙBϚ0˼˷̮˭̕ϙCϚ0 ŻÃʐϙDϚ0¹wµɍΟϙEϚ0ȍʓą̤[įEϙFϚ0Ƭɵ˗˭̕ϙGϚ [ĩƇΟʫ͗ç1¹wµɍΟY:7TSF/SFVSF/Ge[ΧYȞǖƦ<͚
hmpNϙp<0.05Ϛ1
macrophage
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
grafts
evaluation
fibroblast
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
grafts
evaluation
coating amount
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
★
grafts
evaluation
SF/SF PET/SF SF/Gel PET/Gel 0.0
0.5 1.0 1.5 2.0 2.5
smoooth muscle cell
grafts
evaluation
lymphocyte/plasma cell
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
grafts
evaluation
neutrophil
SF/SF PET/SF SF/Gel PET/Gel 0.0
0.5 1.0 1.5 2.0 2.5
grafts
evaluation
neiointimal formation
SF/SF PET/SF SF/Gel PET/Gel 0.0
0.5 1.0 1.5 2.0 2.5
grafts
evaluation
(A) (B)
(C)
(E)
(G)
(F) (D)
"
Figure 11 šȸ3·ȝǃ[4ˉύ[Ñƣ̺˜Y:Ao˯̄ˀȥ[ĩƇΟʫ͗ç
šȸ·ȝǃ[©´ u¹ϙAϚ0±µʐ¸ƽͩ˭̕ϙBϚ0˼˷̮˭̕ϙCϚ0 ŻÃʐϙDϚ0¹wµɍΟϙEϚ0ȍʓą̤[įEϙFϚ0Ƭɵ˗˭̕ϙGϚ [ĩƇΟʫ͗ç1ŻÃʐY:7TPET/SFVSF/SFϙpϢ0.01Ϛ, SF/GELϙpϢ0.05Ϛ :l`SF/GelϙpϢ0.05Ϛ[ΧYȞǖƦ<͚hmpN1Ƭɵ˗˭̕Y:7TSF/SF VPET/SF[ΧYȞǖƦ<͚hmpNϙpϢ0.05Ϛ1
macrophage
SF/SF PET/SF SF/Gel PET/Gel 0.0
0.5 1.0 1.5 2.0 2.5
grafts
evaluation
fibroblast
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
grafts
evaluation
coating amount
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
grafts
evaluation
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3
4 ★
smoooth muscle cell
grafts
evaluation
lymphocyte/plasma cell
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
grafts
evaluation
neutrophil
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
★★
★
★
grafts
evaluation
neiointimal formation
SF/SF PET/SF SF/Gel PET/Gel 0
1 2 3 4
grafts
evaluation
(A) (B)
(C)
(E)
(G)
(F) (D)
Figure 12 ©´ u¹[ĩƇΟʫ͗ç
4ˉύ[Ñƣ̺˜SF/SFϙAϚ0PET/SFϙBϚ0SF/GelϙCϚ0PET/GelϙDϚY:7 TšȸΈΧǃV·ȝǃ[©´ u¹[ĩƇΟʫ͗ç1PTE/GelY:7T ȞǖƦ<͚hmpNϙpϢ0.05Ϛ1
SF/SF
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
PET/SF
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
SF/Gel
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
PTE/Gel
2weeks 3months
0 1 2 3 4
★
implanted period
evaluation
(A) (B)
(C) (D)
Figure 13 ±µʐ¸ƽͩ˭̕[ĩƇΟʫ͗ç
4ˉύ[Ñƣ̺˜SF/SFϙAϚ0PET/SFϙBϚ0SF/GelϙCϚ0PET/GelϙDϚY:7 Tšȸ2ΈΧǃV3·ȝǃ[±µʐ¸ƽͩ˭̕[ĩƇΟʫ͗ç1ȞǖƦ\͚
hmpX;QN1
SF/SF
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
PET/SF
2weeks 3months
1.5 2.0 2.5 3.0 3.5
implanted period
evaluation
SF/Gel
2weeks 3months
0 1 2 3 4
implanted period
evaluation
PET/Gel
2weeks 3months
0 1 2 3 4
implanted period
evaluation
(A) (B)
(C) (D)
˼˷̮˭̕[ĩƇΟʫ͗ç
ˉύ[Ñƣ̺˜ϙϚ0 ϙϚ0ϙϚ0 ϙϚY:7T šȸΈΧǃV·ȝǃ[˼˷̮˭̕[ĩƇΟʫ͗ç1ȞǖƦ\͚hmpX;
QN1
SF/SF
2weeks 3months
0 1 2 3 4
implanted period
evaluation
PET/SF
2weeks 3months
0 1 2 3 4
implanted period
evaluation
SF/Gel
2weeks 3months
0 1 2 3 4
implanted period
evaluation
PET/Gel
2weeks 3months
0 1 2 3 4
implanted period
evaluation
(A) (B)
(C) (D)
Figure 15 ŻÃʐ[ĩƇΟʫ͗ç
4ˉύ[Ñƣ̺˜[SF/SFϙAϚ0PET/SFϙBϚ0SF/GelϙCϚ0PET/GelϙDϚ]Y:7 Tšȸ2ΈΧǃV3·ȝǃ[ŻÃʐ[ĩƇΟʫ͗ç1ȞǖƦ\͚hmpX;Q N1
SF/SF
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
PET/SF
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
SF/Gel
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
PET/Gel
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
(A) (B)
(C) (D)
Figure 16 ¹wµɍΟ[ĩƇΟʫ͗ç
4ˉύ[Ñƣ̺˜[SF/SFϙAϚ0PET/SFϙBϚ0SF/GelϙCϚ0PET/GelϙDϚ]Y:7 Tšȸ2ΈΧǃV3·ȝǃ[¹wµɍΟ[ĩƇΟʫ͗ç1SF/SFY:7T ȞǖƦ<͚hmpNϙpϢ0.01Ϛ1
SF/SF
2weeks 3months
0 1 2 3 4
★★
implanted period
evaluation
PET/SF
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
SF/Gel
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
PET/Gel
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
(A) (B)
(C) (D)
Figure 17 ȍʓą̤[įE[ĩƇΟʫ͗ç
4ˉύ[Ñƣ̺˜[SF/SFϙAϚ0PET/SFϙBϚ0SF/GelϙCϚ0PET/GelϙDϚ]Y:7 Tšȸ2ΈΧǃV3·ȝǃ[ȍʓą̤[įE[ĩƇΟʫ͗ç1ȞǖƦ\͚hm pX;QN1
SF/SF
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
PET/SF
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
SF/Gel
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
PET/Gel
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
implanted period
evaluation
(A) (B)
(C) (D)
Figure 18 Ƭɵ˗˭̕[ĩƇΟʫ͗ç
4ˉύ[Ñƣ̺˜[SF/SFϙAϚ0PET/SFϙBϚ0SF/GelϙCϚ0PET/GelϙDϚ]Y:7 Tšȸ2ΈΧǃV3·ȝǃ[Ƭɵ˗˭̕[ĩƇΟʫ͗ç1SF/SFϙpϢ0.05Ϛ,PET/SF ϙpϢ0.05Ϛ,SF/GelϙpϢ0.05ϚY:7TȞǖƦ<͚hmpN1
SF/SF
2weeks 3months
0 1 2 3
4 ★
grafts
evaluation
2weeks 3months
0 1 2 3
4 ★★
SF/Gel
grafts
evaluation
2weeks 3months
0 1 2 3
4 ★
PET/SF
grafts
evaluation
PET/Gel
2weeks 3months
0.0 0.5 1.0 1.5 2.0 2.5
grafts
evaluation
(A) (B)
(C) (D)
Figure 19 šȸΈΧǃ:l`šȸ·ȝǃ[˯̄èÿʍVąʬĤʍ
ϙAϚšȸ2ΈΧǃ:l`šȸ3·ȝǃ[4ˉύ[Ñƣ̺˜[˯̄èÿʍ1šȸ2 ΈΧǃU\˯̄èÿʍYȞǖƦ\͚hmpX;QN<0šȸ3·ȝǃU\SF/SF VPET/G[ΧYȞǖƦ<͚hmpNϙ*P < 0.05, **P < 0.01Ϛ1ϙBϚšȸ3·ȝǃ [ąʬĤʍ1šȸ3·ȝǃU\SF/SF,PET/SF:l`SF/GUąʬĤ<͚hmpN1 G;GPET/GU\ąʬĤ<ĨďYʻ͚EpJȞǖƦ<͚hmpNϙ**P < 0.01Ϛ1
SF/SF PET/SF SF/Gel PET/Gel 0
5 10 15 20 25
2 weeks
組織侵入率（%）
SF/SF PET/SF SF/Gel PET/Gel 0
20 40 60 80 100
★★
★★
内皮化率（％）
SF/SF PET/SF SF/Gel PET/Gel 0
5 10 15 20 25
★
★★
3 months
組織侵入率（%）
(A)
(B)
!
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zµϚYTśĜsɮƇGN1ºƇ[śĜϙ18 kPaϚYXol8Y͟˝GNǃϛ 7 cm[Ñƣ̺˜[ƤĽ1 cmJRsɄœÝʳGϛÑƣ̺˜;mɶpĎoɘ[Ο sɮƇGNϙFigure 20Ϛ1
3. Ñƣ̺˜[šhͽf3-1. å͘Ġʆ
48ω[Sprague-DawleyϙSDϚ°ϛ¬ϛßΝ200-300 gYÑƣ̺˜sš ȸGN1ãʕGNIbT[°\ȩÐͻƣŵƃ3ƈϒĠʆǰΡij`Ġʆƈϒ
[ǠƷ=4YŤS7Tϐ̒¸˜ʑGϛƈϒȃásƈȏGNϙǣ͚ʞľϠ26-76Ϛ1
3-2. šȸȎɠ
48ω[°[̡ΖŵĠ̙Yϛ1.0%ϛ2.5%ϛ5.0%ϛ7.5%[ϟˉύ[Ñƣ̺˜
ϙΤE10 mmϛąǁ1.5 mmϚsšȸGN14ˉύ[Ñƣ̺˜sLpMp12ωY
šȸGϛšȸ3ΈΧǃY6ω;mϛEmYšȸ3·ȝǃY6ω;mĶnĎGN1 šȸȎɠ\˕1˓VŁȽU6QN1
3-3. šȸ̺˜[z¹ȹȱ
šȸǃ[Ñƣ̺˜[z¹ȹȱ\ϛ˕1˓VŁȽYͬτɡʛö͕Ȍ́̇
ϙProsound -10ϛȑ˒v´}ʾϚsʕ7Tx ²°µ[ńÿϖΙ¾UƈȏG
N1̺˜z¹ȹȱ\ϛšȸϜȑǃϛšɎϜΈΧǃϛĶnĎGʯė ϙ3ΈΧe N3·ȝϚ[͐3ŔƈȏGN1
4. šȸ̺˜[ƽǙƃʫ͗ç
4-1. Ñƣ̺˜[ĶnĎGϛģšϛ̵Đ:l`ȯ̭
ĿšȸȢΧ˰ǃϛ°YÑƣ̺˜šȸȗVŁȽ[ϖΙč̇sȏGϛ˕1
˓VŁȽ[ȎɠUÑƣ̺˜sĶnĎGϛřƇǃY̵ĐGT˯̄ȿȥsá̈́GN1
̵ĐʅY\ƫɠYDžQTHEȯ̭ϛMTCȯ̭sȏGN1
4-2. ˯̄ƃʫȹȱ
˕1˓VŁȽYϛHEȯ̭ȿȥU\Ñƣ̺˜a[ɼʤǑ˭̕ɧɸsÃNjY˯̄
Āß[ȼΆs͗çGN1eNϛMTCȯ̭ȿȥU\Ñƣ̺˜Ňŗ:l`Ñƣ̺˜
ąa[̦İ˼˷[Õʳjèÿ[ˈƱs͗çGN1ýʡ˯̄Ĥƃʫȯ̭U\ϛ˕1
˓VŁȽY̺˜ąʬ˭̕[ȹĎYCD31ϛƬɵ˗˭̕[ȹĎY-SMAsʕ7T
DABYlnʩ̭EKN1X:ϛɼʤǑ˭̕ϛ¹wµɍƂΟϛȍʓą̤[
ƽǜϛƬɵ˗˭̕[ŭɎYΨIo͗çs˕1˓VŁȽYLpMp0-3U͗çGN1 EmYCpm[¹͍ȫ\˕1˓VŁȽ[ȎɠU̻QN1
4-3. ʛö͍ȫ
˕1˓VŁȽYûƃόljΣϙBZ-9000ϛ¹zµϚUMTCȯ̭ȿȥs͌Ɛ GϛǿEpT7oʛö͍ȫ sʕ7T˯̄èÿʍVą̝ǁs͐ɮGN1
1) ˯̄èÿʍ
˯̄èÿʍ[˛Ď\˕1˓VŁȽY̻QN1 2) ą̝ǁ
Ñƣ̺˜[ɊfXWYlo͜ƦsȜƕĤIoNhϛÑƣ̺˜ąòσ[ΤEs
ĆŇʍϙϚUΰIoCVUϛÑƣ̺˜[ą̝ǁs˛ĎGN1ą̝[ĀΤ\
±¹µYTąòσs°µGTɮƇGN1
3) ˴͐
˯̄èÿʍ:l`ą̝ǁ[˴͐ƃʫXɓͷ\ϛone-way ANOVAVBonferroni ɠYŤS7TƈȏGN1Cpm[¹͍ȫY\GraphPad PrismϙVersion 5.0aϛ
z«¹z Ϛsʕ7N1˴͐ƃʫȞǖƦɘɲ\5%VGN1͐ɮð\ƬŞð± ȿɲñƦUʼGN1
!
˱ȭ
1. Ñƣ̺˜[ƽǙƃʫ:l`ʆǑʫ͗ç
1-1. SEMYloÑƣ̺˜[͌Ɛ
SEMʛöYlQTdžmpN¹wµė[ŤʭV¹wµǃ[Ñƣ̺
˜[ąòσVŲòσ[ʛöϙFigure 21ϚU\ϛ¹wµėY\° YΧ
δ<ȔʴY͌ƐEpN[YƑGTϛ¹wµǃY\¹wµɺƱ[ŭ
ĝYViXQTΧδ<Ɇ˕YƕE?XQNϙFigure 22Ϛ11.0%V2.5%YR7T\
¹wµǃYiąòσYΧδ<fmpϛʇY1.0%U\ŲòσYi° [˼˷<ʻ͚EpN1ºȎϛ5.0%V7.5%U\ϛ7JpiŲòσ\¹wµ
YlQT͇rpT:nϛąòσYi˼˷Χ[δΧ\cVtW͚hmpX;Q
N1
1-2. HE:l`MTCȯ̭YloÑƣ̺˜[͌Ɛ
¹wµė[Ťʭ[f[ʈǙU\ϛHEȯ̭VMTCȯ̭[7JpY:7 Tių?[Χδ<ʻ͚EpNϙFigure 23Ϛ1ºȎϛ¹wµǃY\SEM[
˱ȭVŁȽYΧδ\Ȕm;YƕE?XQT7N1X:ϛÑƣ̺˜[įEY\
"
¹wµ[ˈƱYloΏ7\͚hmpX;QN1
1-3. ¹wµΝΟɓ
¹wµΟ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 15.35.6 %ϡ 2.5 %, 30.81.0 %ϡ 5.0 %, 40.85.3 %ϡ 7.5 %, 57.31.3 %1X:ϛ1.0 %V2.5 %ϙ
Ϛϛ 5.0 %V1.0 %ϙϚ:l`2.5 %ϙϚϛ 7.5 %V1.0 %
ϙϚϛ2.5 %ϙϚ:l`5.0 %ϙϚV[ΧYȞǖƦ
<͚hmpNϙFigure 24 ϙAϚϚ1
1-4. ʆǑ͘ϒ 1) Ņŀìǯ͘ϒ
Ņŀìǯ͘ϒ[˱ȭ\×¾[V:nU6QNϠ 1.0%, 0.640.34 Nϡ 2.5%, 1.0 0.42 Nϡ 5.0%, 3.30.71 %ϡ 7.5%, 4.40.86 N1X:ϛ5.0 %V1.0 %ϙϚ
:l`2.5 %ϙϚϛ7.5 %V1.0 %ϙϚϛ2.5 %ϙϚ:
l`5.0 %ϙϚV[ΧYȞǖƦ<͚hmpNϙFigure 24 ϙBϚϚ1
!
2) ś́ƻǑʍ
ś́ƻǑʍ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 0.00160.00045 N/mm2ϡ
2.5 %, 0.00600.0013 N/mm2ϡ 5.0 %, 9.21.5 N/mm2ϡ 7.5 %, 8.01.7 N/mm21 X:ϛ5.0 %V1.0 %ϙϚ:l`2.5 %ϙϚϛ 7.5 %V1.0 %ϙ Ϛϛ2.5 %ϙϚ:l`5.0 %ϙϚV[ΧYȞǖƦ<͚h mpNϙFigure 24 ϙCϚϚ1
3) ɘ͘ϒ
ɘ͘ϒ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 51.41.1 ml/5cm/minϡ 2.5 %, 48.05.2 ml/5cm/minϡ 5.0 % 36.27.6 ml/5cm/min, 7.5 % 21.69.7 ml/5cm/min1 X:ϛ1.0 %V5.0 %ϙϚ:l`7.5 %ϙϚϛ 2.5 %V7.5 %ϙ Ϛϛ5.0 %V7.5 %ϙϚV[ΧYȞǖƦ<͚hmpNϙFigure 24 ϙDϚϚ1
2. Ñƣ̺˜[šhͽf2-1. šȸǠǤ:l`šȸȗΧ
Ñƣ̺˜[šȸYεGTϛ1.0%[Ñƣ̺˜U\ŅŀȗỲŀΖÝYͶƱXc
Rp<fmpNi[[ϛšȸ\Ļ̖U6QN1Ô[¹wµɺƱU\cR
p\͚hmpX;QN1eNϛµ´¹²ŖνXĎ̺\W[ɺƱY:7Ti
!
͚hmpJϛ48ωIbT[°UÑƣ̺˜[šȸ<Ļ̖U6QN14ˉύ[
Ñƣ̺˜[šɎȗΧYƦ\X?ϛ̺ɦΒȌȗΧ\30-45ďΧU6nϛšȸY;;
QNȗΧ\45-60ďU6QN1eNϛ7Jp[°iĶnĎGÊƇȑeUʓƂ Gϛz¹ȹȱ:l`ĶnĎG<Ļ̖U6QN1
2.2 šȸ̺˜[z¹ȹȱ
šȸϜΈΧǃeU\ϛz¹ȹȱYlnIbT[° UΦƂ<ʻ͚Ep
N1šȸ3ΈΧǃU\ϛ¹wµɺƱ<2.5 %[̺˜V7.5 %[̺˜ULp MpϜωJRΥŪGT7N<ϛLp×ŲU\ΦƂ<ʻ͚EpN1eNϛšȸ3
·ȝǃ[i[U\5.0 %[i[<1ωΥŪGT7N1Cpm3ω[ΥŪäYR7 T\˯̄èÿʍϛąʬĤϛą̝ǁXW[͗ç;mΰŲGNϙTable 5Ϛ1
3. šȸ̺˜[̎ʲʫ:l`˯̄ƃʫ͗ç 3.1 ̎ʲʫǞ͈
šȸ3·ȝǃ[ĶnĎGȗY:AoÑƣ̺˜[̎ʲʫȹ˫U\ϛήƙǑǭƹ jŅŀΖY:AoÑƣ̺˜[ʹ̀XW[ʟƫ\͚hmpX;QN1eNϛ¹
!
wµɺƱ<Þ7cWÑƣ̺˜[ŇŗYų?[̨Ƨ˯̄<ǹʳGT7N1º
Ȏϛ¹wµɺƱ<ϕ7Ñƣ̺˜U\¹wµ<ŇŗYų?ɍQNe
eU6nϛ;Rą̤Y\̑į<͚hmpN1¹wµɺƱ<Þ7Ñƣ̺˜
U\ą̤̑į\͌ƐEpX;QN1X:ϛ4ˉύIbT[Ñƣ̺˜ąòσY̺Ȳ XW[Õʳ\͚hmpX;QNϙFigure 25Ϛ1
3.2 ˯̄ƃʫȹȱǞ͈
šȸ3ΈΧǃU\4ˉύ[Ñƣ̺˜Yų?[±µʐVƽͩ˭̕<ɧɸGT 7N1L[ąòϛRen¹wµΖďY\©´ u¹Vųȳƥ˭̕<
ų?͚hmpN1C[¹wµYR7T\5.0%V7.5%Uų?ɍƂGT7N1 ŤʭsȼǜIo˼˷[ŇŗYi©´ u¹<ɧɸGT7N1eNϛŻÃʐ
[ɧɸi͚hmpN<ϛÔ[ɼʤǑ˭̕VɓͷGTL[Ȉ\ƖX;QN11.0%
V2.5%U\˼˷̮˭̕<Ñƣ̺˜[ŮąYiʻ͚EpN<ϛºȎU5.0%V7.5%
U\ų?<Ñƣ̺˜[ŇŗYɧɸ¸ŭɎGT7NϙFigure 26Ϛ1
šȸ3·ȝǃU\Ñƣ̺˜Ňŗ[±µʐVƽͩ˭̕\ɬƖGT7N<ϛĀ ß[ΟVGT\šȸϞΈΧǃVŵ=XΏ7\X;QN1eNϛ©´ u¹
!
iɬƖGT7N<ϛŻÃʐYR7T\šȸ3ΈΧǃVɓbTcVtWűĤGT 7X;QN1˼˷̮˭̕[ȈYŵ=XűĤ\fmpX7i[[ϛšȸ3ΈΧǃ VɓͷGTÑƣ̺˜[ąΖYių?͈7OEpNϙFigure 27Ϛ1̺˜ąʬ˭̕\
4ˉύ[Ñƣ̺˜Uą̤s͇QT7o[<ʻ͚EpN<ϛ7.5%U\Lp<¿Ĩď U6QN1eNϛ̺˜ąʬ˭̕[¾ƜY\Ƭɵ˗˭̕<ºƜƽǜEpT7N
ϙFigure 28Ϛ1
×¾Y4ˉύ[Ñƣ̺˜YΨIoɼʤǑ˭̕ϛ¹wµɍΟϛȍʓą̤
[įE:l`Ƭɵ˗˭̕[ĩƇΟʫ͗ç[˱ȭsʼIϙTable 6Ϛ1
1) ©´ u¹
šȸ3ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ 1.0 %, 2.5±0.50ϡ 2.5 %, 2.2±0.37ϡ 5.0 %, 1.2±0.37ϡ 7.5 %, 1.2±0.3711.0 %V5.0 %ϙpϢ0.05Ϛ:l`7.5 % ϙpϢ0.05ϚV[ΧYȞǖƦ<͚hmpNϙFigure 29Ϛ1eNϛšȸ3·ȝǃ[˱
ȭ\×¾[V:nU6QNϠ1.0 %, 1.3±0.47ϡ 2.5 %, 1.3±0.47ϡ 5.0 %, 1.2±0.37ϡ 7.5 %, 1.2±0.37ϙFigure 30Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ3ΈΧǃV 3·ȝǃsɓͷIoVϛ1.0 %ϙpϢ0.05Ϛ:l`2.5 %ϙpϢ0.05ϚYȞǖƦ<͚
hmpNϙFigure 31Ϛ1
!
2) ±µʐ¸ƽͩ˭̕
šȸ3ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 2.5±0.50ϡ 2.5 %,
2.8±0.37ϡ 5.0 %, 2.3±0.47ϡ 7.5 %, 12.3±0.47ϙFigure 29Ϛ1eNϛšȸ3·ȝǃ [˱ȭ\×¾[V:nU6QNϠ1.0 %, 2.50±0.50ϡ 2.5 %, 2.3±0.47ϡ 5.0 %, 2.0±0ϡ 7.5 %, 2.7±0.47ϙFigure 30Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ3ΈΧǃV 3·ȝǃV[ΧYȞǖƦ\͚hmpX;QNϙFigure 32Ϛ1
3) ˼˷̮˭̕
šȸ3ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 2.3±0.47ϡ 2.5 %,
2.5±0.50ϡ 5.0 %, 2.8±0.37ϡ 7.5 %, 2.8±0.37ϙFigure 29Ϛ1eNϛšȸ3·ȝǃ[
˱ȭ\×¾[V:nU6QNϠ1.0 %, 2.2±0.37ϡ 2.5 %, 1.5±0.50ϡ 5.0, % 2.7±0.47ϡ 7.5 %, 2.7±0.471X:ϛ2.5 %V7.5 %V[ΧYȞǖƦ<͚hmpNϙpϢ0.05ϡFigure 30Ϛ1LpMp[Ñƣ̺˜Y:7Tšȸ3ΈΧǃV3·ȝǃsɓͷIoVϛ2.5 % YȞǖƦ<͚hmpNϙpϢ0.05ϡFigure 33Ϛ1
4) ŻÃʐ
šȸ3ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ 1.0 %, 1.2±0.37ϡ 2.5 %, 1.3±0.47ϡ 5.0 %, 1.2±0.37ϡ 7.5 %, 1.2±0.37ϙFigure 29Ϛ1eNϛšȸ3·ȝǃ[
!
˱ȭ\×¾[V:nU6QNϠ1.0 %, 1.2±0.37ϡ 2.5 %, 1.2±0.37ϡ 5.0 %, 1.2±0.37ϡ 7.5 %, 1.2±0.37ϙFigure 30Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ3ΈΧV3
·ȝǃV[ΧYȞǖƦ\͚hmpX;QNϙFigure 34Ϛ1 5) ¹wµɍΟ
šȸ3ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 0.50±0.50ϡ 2.5 %,
1.7±0.47ϡ 5.0 %, 2.2±0.37ϡ 7.5 %, 2.7±0.4711.0 %V5.0 %ϙpϢ0.05Ϛ:l`7.5 % ϙpϢ0.01ϚV[ΧYȞǖƦ<͚hmpNϙFigure 29Ϛ1eNϛšȸ3·ȝǃ[˱
ȭ\×¾[V:nU6QNϠ1.0 % 0.17±0.37, 2.5 % 1.2±0.90, 5.0 % 2.5±0.50, 7.5 % 2.5±0.7611.0 %V5.0 %ϙpϢ0.05Ϛ:l`7.5 %ϙpϢ0.01ϚV[ΧYȞǖƦ<͚
hmpNϙFigure 30Ϛ1ºȎϛLpMp[Ñƣ̺˜Y:7Tšȸ3ΈΧǃV3· ȝV[ΧYȞǖƦ\͚hmpX;QNϙFigure 35Ϛ1
6) ȍʓą̤[įE
šȸ3ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 1.7±0.47ϡ 2.5 %, 1.3±0.75ϡ 5.0 %, 1.0±0.58ϡ 7.5 %, 1.3±0.75ϙFigure 29Ϛ1eNϛšȸ3·ȝǃ[
˱ȭ\×¾[V:nU6QNϠ1.0 % 1.3±0.75ϡ 2.5 %, 1.7±0.47ϡ 5.0 %, 2.7±0.47ϡ 7.5 %, 2.5±0.50ϙFigure 30Ϛ1X:ϛLpMp[Ñƣ̺˜Y:7Tšȸ3ΈΧǃV
!
3·ȝǃsɓͷIoVϛ5.0 %ϙpϢ0.05Ϛ:l`7.5 %ϙpϢ0.05ϚYȞǖƦ<͚
hmpNϙFigure 36Ϛ1
7) Ƭɵ˗˭̕
šȸ3ΈΧǃ[˱ȭ\×¾[V:nU6QNϠ1.0 %, 1.2±0.37ϡ 2.5 %, 1.0±0.58ϡ 5.0 %, 1.3±0.75ϡ 7.5 %, 1.8±0.90ϙFigure 29Ϛ1eNϛšȸ3·ȝǃ[
˱ȭ\×¾[V:nU6QNϠ1.0 %, 1.0±0.58ϡ 2.5 %, 1.5±0.50ϡ 5.0 %, 2.5±0.50ϡ 7.5 %, 2.8±0.3711.0 %V5.0 %ϙpϢ0.05Ϛ:l`7.5 %ϙpϢ0.01Ϛ, 2.5 %V7.5 % ϙpϢ0.05ϚV[ΧYȞǖƦ<͚hmpNϙFigure 30Ϛ1X:ϛLpMp[Ñƣ̺
˜Y:7Tšȸ3ΈΧǃV3·ȝǃsɓͷIoVϛ5.0 %ϙpϢ0.05Ϛ:l`7.5 % ϙpϢ0.05ϚYȞǖƦ<͚hmpNϙFigure 37Ϛ1
3-3. ʛö͍ȫ 1) ˯̄èÿʍ
šȸ3ΈΧǃ[˯̄èÿʍ\×¾[V:nU6QNϠ1.0 %, 8.0±3.3 %ϡ 2.5 %, 20.3±4.5 %ϡ 5.0 %, 9.2±1.5 %ϡ 7.5 %, 8.0±1.7 %1 1.0 %V7.5 %ϙϚ,
2.5 %V5.0 %ϙϚ:l`7.5 %ϙϚV[ΧYȞǖƦ<͚hm
!
pNϙFigure 38 ϙAϚϚ1eNϛšȸ3·ȝǃ[˯̄èÿʍ\×¾[V:nU6 QNϠ 1.0 %, 31.2±7.5 %ϡ 2.5 %, 25.8±5.2 %ϡ 5.0 %, 6.7±2.2 %ϡ 7.5 %, 10.0±3.1 %1 1.0 %V5.0 %ϙϚ:l`7.5 %ϙϚ, 2.5 %V5.0 %ϙϚ :l`7.5 %ϙϚV[ΧYȞǖƦ<͚hmpNϙFigure 38 ϙBϚϚ1 2) ą̝ǁ
šȸ3ΈΧǃ[˯̄èÿʍ\×¾[V:nU6QNϠ1.0 %, 1360.0±92.1mϡ 2.5 %, 1484.0±137.8mϡ 5.0 %, 1321.7±45.8mϡ 7.5 %, 1243.3±120.9m 12.5
%V7.5 %V[ΧYȞǖƦ<͚hmpNϙϡ Figure 38 ϙCϚϚ1ºȎϛ
šȸ3·ȝǃ[ą̝ǁ\×¾[V:nU6QNϠ 1.0 %, 1661.7±175.8mϡ 2.5 %, 1568.3±56.4mϡ 5.0 %, 1168.0±63.8mϡ 7.5 %, 1133.7±110.0m11.0 %V5.0%
ϙϚ:l`7.5%ϙϚ, 2.5 %V5.0 %ϙϚ:l`7.5 %
ϙϚV[ΧYȞǖƦ<͚hmpNϙFigure 38 ϙDϚϚ1
!!
̋Ɛ
šȸȒȢU[̺ȲƽǜjøΤȢY:Aoą̤[̑į\ϛȽ2XȦȋ[ƕĸ
ǁÑƣ̺˜UŏϋVXQT7o<ϛLpm2R[ŏϋɽ[7JpYi¹w µ[Ǒ̖<ΨÀGT7oCV<Ȕm;YEpT7o(42, 53, 54, 57, 72, 91)1˕
1˓Y:7TŤʭlni¹wµ[Ȏ<Ñƣ̺˜YÀ9oƿυ<ŵ=7C V<Ȕm;YXQNCV;miϛ¹wµ[Ǒ̖ł½\Ñƣ̺˜[ΦʩY
:7TǐġV79o1
šȸȒȢ[̺ȲƽǜsÊΫGTÑƣ̺˜sΦƂEKoY\ϛ̺ȲƽǜYlo
ʉˏV̺Ȳ[œͩĤYloą̤[̑įsǥ9onj͆<6nϛȒȢ[ąʬĤ<Ν
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