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1'Yano M, Tsujinaka T, Shiozaki H, et al. Con-current chemotherapy&5-fluorouracil and cis-platin'and radiation therapy followed by sur-gery for T4 squamous cell carcinoma of the esophagus. J Surg Oncol. 70#25%32, 1999. 2' Yano M , Shiozaki H , Tsujinaka T , et al .

Squamous cell carcinoma of the esophagus infiltrating the respiratory tract is less sensi-tive to preoperasensi-tive concurrent radiation and chemotherapy . J Am Coll Surg . 191# 626%634, 2000.

3'Noguchi T, Moriyama H, Wada S, et al. Re-section surgery with neoadjuvant chemora-diotherapy improves outcomes of patients with T4 esophageal carcinoma. Dis Esopha-gus. 16#94%98, 2003.

4'Ikeda K, Ishida K, Sato N, et al. Chemoradio-therapy followed by surgery for thoracic esophageal cancer potentially or actually in-volving adjacent organs . Dis Esophagus . 14#197%201, 2001.

5'Fujita H, Sueyoshi S, Tanaka T, et al. Pro-spective non-randomized trial comparing esophagectomy-followed-by-chemoradiothe-rapy versus chemoradiotheesophagectomy-followed-by-chemoradiothe-rapy-followed-by- chemoradiotherapy-followed-by-esophagectomy for T4 esophageal cancers. J Surg Oncol. 90#209%219, 2005.

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6&Fujita H , Sueyoshi S , Tanaka T , et al . Esophagectomy " is it necessary after chemoradiotherapy for a locally advanced T4 esophageal cancer? Prospective nonran-domized trial comparing chemoradiotherapy with surgery versus without surgery. World J Surg. 29"25$31, 2005.

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Definitive chemoradiation in patients with in-operable oesophageal carcinoma . Br J Can-cer. 90"70$75, 2004.

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13&Ishida K, Ando N, Yamamoto S, Ide H, Shi-noda M . Phase II study of cisplatin and 5-fluorouracil with concurrent radiotherapy in advanced squamous cell carcinoma of the esophagus" a Japan Esophageal Oncology

Group% JEOG &!Japan Clinical Oncology Group trial%JCOG9516&.Jpn J Clin Oncol. 34"615$619, 2004.

14&Nishimura Y, Suzuki M, Nakamatsu K, et al. Prospective trial of concurrent chemoradio-therapy with protracted infusion of 5-fluo-rouracil and cisplatin for T4 esophageal can-cer with or without fistula. Int J Radiat Oncol Biol Phys. 53"134$139, 2002.

15&JCOG Y`cLIdC?05#2 NX)/ 05#2 JCOG0303%phaseII!III&BKOEA [NX)/,T*. Low Dose Cisplatin!5-FU!^HQWG\ab_+ Standard Dose Cisplatin!5-FU!^HQWG\ab_+-4 6138U II!III SFD

16&Tachimori Y, Kato H, Watanabe H. Surgery for thoracic esophageal carcinoma with clini-cally positive cervical nodes. J Thorac Car-diovasc Surg. 116"954$959, 1998.

17&Igaki H, Kato H, Tachimori Y, Sato H, Daiko H , Nakanishi Y . Prognostic evaluation for squamous cell carcinomas of the lower tho-racic esophagus treated with three-field lymph node dissection . Eur J Cardiothorac Surg. 19"887$893, 2001.

18&Malaisrie SC, Hofstetter WL, Correa AM, et al. Endoscopic ultrasonography-identified ce-liac adenopathy remains a poor prognostic factor despite preoperative chemoradiother-apy in esophageal adenocarcinoma. J Thorac Cardiovasc Surg. 131"65$72, 2006.

19&Marsman WA, van Wissen M, Bergman JJ, et al. Outcome of patients with esophageal carcinoma and suspicious celiac lymph nodes as determined by endoscopic ultrasonogra-phy. Endoscopy. 36"961$965, 2004.

20&Natsugoe S, Yoshinaka H, Shimada M, et al. Number of lymph node metastases deter-mined by presurgical ultrasound and endo-scopic ultrasound is related to prognosis in 2006Z%]P18Z&VR>Y`M8=;9<:@7J:

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patients with esophageal carcinoma . Ann Surg. 234#613$618, 2001.

21&Kato H, Tachimori Y, Watanabe H, et al. In-tramural metastasis of thoracic esophageal carcinoma. Int J Cancer. 50#49$52, 1992. 22&Yuasa N, Miyake H, Yamada T, et al.

Prog-nostic significance of the location of intramu-ral metastasis in patients with esophageal squamous cell carcinoma. Langenbecks Arch Surg. 389#122$127, 2004.

23&Hokamura N, Kato H, Tachimori Y, et al. Pre-operative chemotherapy for esophageal car-cinoma with intramural metastasis . J Surg Oncol. 75#117$121, 2000.

24&Kato H, Udagawa H, Togo A, et al. For the Japan Clinical Oncology Group%JCOG&. A phase II trial of chemo-radiotherapy in pa-tients with stage I esophageal squamous cell carcinoma#Japan Clinical Oncology Group study%JCOG9708&Abstract No#1147 Proc Am Soc Clin Oncol. 22#286, 2003.

25&Hattori S, Muto M, Ohtsu A, et al. EMR as salvage treatment for patients with locore-gional failure of definitive chemoradiother-apy for esophageal cancer. Gastrointest En-dosc. 58#65$70, 2003.

26&Ohtsu A. Chemoradiotherapy for esophageal cancer#current status and perspectives. Int J Clin Oncol. 9#444$450, 2004.

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30&_y;O!‚L8dY"'i}@^‰.)*1 controversy(i } @ . ) * 1 salvage sur-gery Šf=: 57#191$198, 2002. 31&M|ywm!puNn!CyeZ!v"Fƒ =:/[l S^x…`s9>‰†M/i} @EVac Fƒ=: 55#743$745, 2002. 32&Utj„!Hy I!qBJ~Œ!rW;P! R{oN S^x9>…`s‰†M. sal-vageac2\Q+,Fƒi}@h‹ €‡ g9A=:><X] 37#1378$1383, 2004. 33&DWbC!ˆK k '@^‰.)*1UG/ 67534(i}@ S^x9>…`s‰† - Salvage ac €‡=:><X] 105# 485$488, 2004.

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dose chemoradiotherapy followed by gectomy for adenocarcinoma of the esopha-gus and gastroesophageal junction#results of a phase II study of the Eastern Coopera-RzkQ@/^‰%9>…`s‰†/T‹/^‰2?0&

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tive Oncology Group . Cancer . 83" 1908 $ 1916, 1998.

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113"1934$1939, 2004.

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2006

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図 1 Stage  I  I,I  I  Iの治療効果 図 2 Chemoradi otherapyの生存曲線 )Ke-GAOU?R,_X(0NP+B%/1 )&#34; 2L-@Z&amp;/!QI5^M[;,V(0H8 Cd+'*-4:aDRdb-SW.96QIE2006]#`N18]$YT=\cJ4&lt;96:7&gt;3F7 &#34;#!
表 1 食道切除術後合併症 術前無治療Salvage (n=185)(n=58) (28%)51(34%)20呼吸器合併症 (18%)34(33%)19消化器合併症 (4%)7(9%)5循環器合併症 (11%)21(19%)11感染合併症 在院期間 (80%)147(59%)3430日以内 (17%)32(29%)1731日以上 (3%)6(12%)7在院死 表 2 食道切除術後の気管気管支壊死穿孔 予後他の因子再建経路頸部郭清気管支動脈症例 死亡胸骨後あり切除No.1 生存頸部縫合不全→縦隔炎胸骨後あり温
図 3 食道切除術後生存曲線 s`NìÉ3L&lt;zuzu¥?i§&lt;˓NÉ2 7$ó 2 %&#34;íhÆ%7?ìÉ-Ù/!dtý¬ Ì2ÿ‘?9›d&gt;ILíhÆ°U?®µÔŸ ?šéÆ-”*JM7&#34;œŠ†6;@!™‘!ï c†6œŠ5;zuzu¥?i§&lt;˓!²s` -Ù,97&#34; Salvage ÁèÊ·&lt;µÏ(©2ÁèÊ·?µ‘ ÉփÌN‹æ17$Å 3 %&#34;Salvage ÁèÊ·; ?µà‘?ÉÖ.?ác@10&amp;S¾?ž]§&#3

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