Title マウスの脳機能におけるL型アミノ酸オキシダーゼの生理学的役割に関する研究( 要約版(Digest) ) Author(s) 臼田, 賢人 Report No.(Doctoral Degree) 博士(獣医学) 甲第518号 Issue Date 2019-03-13 Type 博士論文 Version none URL http://hdl.handle.net/20.500.12099/77949 ※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。
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ࢆ⾜ࡗࡓࠋẕங୰పศᏊ௦ㅰ⏘≀ࡢ⥙⨶ⓗゎᯒࡼࡾ/$2.2 ࣐࢘ࢫࡢẕங୰ ࣇ࢙ࢽࣝࣛࢽࣥ࠾ࡼࡧ࣓ࢳ࢜ࢽࣥ⃰ᗘࡀ㔝⏕ᆺ࣐࢘ࢫࡢẕஙẚ㍑ࡋ࡚᭷ព ቑຍࡋ࡚࠸ࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡲࡓ ⏕ᚋ ᪥௨ෆ㣴ẕฎ⨨ࢆ ࡋࡓ࣐࢘ࢫࡢᡂ㛗ᚋ⾜ືヨ㦂ࢆ⾜ࡗࡓ⤖ᯝ/$2 .2 ࣐࢘ࢫࡢẕஙࢆᦤ ྲྀࡋࡓ࣐࢘ࢫࡣ㔝⏕ᆺ࣐࢘ࢫࡢẕஙࢆᦤྲྀࡋࡓ࣐࢘ࢫẚ㍑ࡋ࡚✵㛫グ᠈࣭Ꮫ ⩦⬟ຊࡀపୗࡍࡿࡇࡀศࡗࡓࠋࡑࡢせᅉࡋ࡚ࡣ/$2.2 ࣐࢘ࢫࡢẕஙࢆ ᦤྲྀࡋࡓ࣐࢘ࢫࡢᾏ㤿ෆ*UPP51$ Ⓨ⌧㔞ࡢῶᑡࡀ⪃࠼ࡽࢀࡓࡀ/$2㸯Ḟᦆ ࡼࡿẕங୰㐟㞳࣑ࣀ㓟௦ㅰࡢኚࡢ㛵㐃ᛶࢆゎ᫂ࡍࡿࡲ࡛ࡣ⮳ࡽ࡞ࡗ ࡓࠋ୍᪉ẕஙᦤྲྀ୰ࡢ ᪥㱋࣐࢘ࢫࡢ⾑₢୰పศᏊ௦ㅰ⏘≀ࡢ⥙⨶ⓗゎᯒ ࡼࡾ/$2 .2 ࣐࢘ࢫࡢẕஙࢆᦤྲྀࡋࡓ࣐࢘ࢫࡢ⾑୰ࢣࢺࣥయ⃰ᗘࡢቑຍࡸࣉ ࣜࣥయ௦ㅰ␗ᖖࡀㄆࡵࡽࢀࡓࠋ⾑୰ࢣࢺࣥయ⃰ᗘࡢቑຍࡣ ẕஙࡼࡿ࣐࢘ ࢫࡢ࢚ࢿࣝࢠ࣮౪⤥ࡀ༑ศ࡛࠶ࡿࡇࢆ♧၀ࡋ࡚࠾ࡾ ࢚ࢿࣝࢠ࣮㊊ ࡼࡾࡢ⬻ᶵ⬟Ⓨ㐩ࡀᙳ㡪ࢆཷࡅࡓࡇࡀ⪃࠼ࡽࢀࡓࠋࡇࢀࡽࡢ⤖ᯝࡣ⫱ඣ⏝ ࣑ࣝࢡࡢᨵⰋࡸ ẕங୰ᡂศࡢࣔࢽࢱࣜࣥࢢࡼࡿ⬻ᶵ⬟Ⓨ㐩㞀ᐖࡢண㜵࡞ ࡢ◊✲ᛂ⏝࡛ࡁࡿᛮࢃࢀࡓࠋ ➨ ❶࡛ࡣ /$2 ࡢⓎ⌧ࡀㄆࡵࡽࢀࡓᾏ㤿ࡢࢫࢺࣞࢫឤཷᛶࡢ㧗ࡉὀ┠ࡋ 㐌㛫ࡢ༢㣫࠸㣫⫱ࡼࡿᏙ⊂ࢫࢺࣞࢫࡀ࣐࢘ࢫࡢ⬻ᶵ⬟ཬࡰࡍᙳ㡪㛵ࡋ ࡚ 㔝⏕ᆺ/$2 .2 ࣐࢘ࢫ࡛㐪࠸ࡀㄆࡵࡽࢀࡿࢆ᥈⣴ࡋࡓࠋ⾜ືヨ㦂࡛ࡣ 㔝⏕ᆺ࣐࢘ࢫࡢ⾜ື⾲⌧ᆺ⩌㣫࠸ࡢᕪࡣㄆࡵࡽࢀ࡞ࡗࡓࡀ/$2 .2 ࣐ ࢘ࢫ࡛ࡣ㐠ືᛶᏳᵝ⾜ືࡢቑຍࡀ☜ㄆࡉࢀ/$2 .2 ࣐࢘ࢫࡣ㔝⏕ᆺ࣐࢘ ࢫẚ㍑ࡋ࡚༢㣫࠸ࢫࢺࣞࢫᑐࡍࡿឤཷᛶࡀ㧗࠸ࡇࡀ⪃࠼ࡽࢀࡓࠋࡲࡓ ࢫࢺࣞࢫࡼࡿ࠺ࡘᵝ≧ࡢⓎᐦ᥋㛵㐃ࡋ࡚࠸ࡿ⅖ᛂࡘ࠸࡚ /$2.2 ࣐࢘ࢫࡢᾏ㤿ෆࣥࢱ࣮ࣟ࢟ࣥ,/șP51$ ࠾ࡼࡧ ,/P51$ Ⓨ⌧ 㔞ࡀ᭷ពቑຍࡋ࡚࠸ࡿࡇࡀศࡗࡓࠋࡇࢀࡽࡢ⤖ᯝ➨ ❶࡛᫂ࡽࡋ ࡓ/$2 Ḟᦆࡼࡿᾏ㤿ෆ࣑ࣀ㓟௦ㅰࡢኚࢆ⤖ࡧࡅ࡚⪃࠼ࡿࡇ࡛Ꮩ⊂ ࡼࡿ⬻ᶵ⬟ࡢపୗᑐࡋ࡚ ࣑ࣀ㓟ࢆྵࡴ⤒ཱྀࢧࣉ࣓ࣜࣥࢺ࡞ࡢண㜵࣭ ⒪᪉ἲࡢ㛤Ⓨࡘ࡞ࡀࡿࡇࡀ♧၀ࡉࢀࡓࠋ ᮏ◊✲ࡣ /$2 ࡼࡿ࣑ࣀ㓟௦ㅰ⬻ᶵ⬟ࡢ㛵㐃ᛶࢆ᫂ࡽࡍࡿࡇࢆ ┠ⓗࡋ࡚/$2.2 ࣐࢘ࢫࢆ⏝࠸ࡓ◊✲ࢆ㐙⾜ࡋࡓࠋ➨ ❶࡛ࡣ/$2.2 ࣐ ࢘ࢫࡢᾏ㤿ෆࢭࢳࣝࢥࣜࣥ⃰ᗘࡢῶᑡࡼࡿグ᠈࣭Ꮫ⩦ᶵ⬟పୗࢆ᫂ࡽ ࡋ࡚ ᾏ㤿ෆࣇ࢙ࢽࣝࣛࢽࣥࡢ✚ࡀཎᅉ࡛࠶ࡿྍ⬟ᛶࢆ♧ࡋࡓࠋ➨ ❶࡛ ࡣ/$2.2 ࣐࢘ࢫࡢẕஙࢆᦤྲྀࡋࡓࡣᡂ㛗ᚋࡢ✵㛫グ᠈࣭Ꮫ⩦ᶵ⬟ࡀపୗ ࡍࡿࡇࢆ☜ㄆࡋ ࡑࡢせᅉࡋ࡚ᾏ㤿ෆ*UP P51$ Ⓨ⌧㔞ࡢῶᑡࡀ⪃࠼ࡽࢀ ࡓࠋࡉࡽ/$2.2 ࣐࢘ࢫࡢẕஙࢆᦤྲྀࡋࡓ࣐࢘ࢫ࡛ࡣ࢚ࢿࣝࢠ࣮㊊ࡀ♧ ၀ࡉࢀࡑࡢ⤖ᯝࡋ࡚ࡢ⬻ᶵ⬟Ⓨ㐩ࡀᙳ㡪ࢆཷࡅࡓࡇࡀ⪃࠼ࡽࢀࡓࠋ➨ ❶࡛ࡣ/$2 .2 ࣐࢘ࢫࡣ༢㣫࠸ࢫࢺࣞࢫឤཷᛶࡀ㧗࠸ࡇࢆ᫂ࡽࡋ࡚
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