Report No.(Doctoral Degree) 博士(獣医学) 甲第583号 Issue Date 2021-03-15 Type 博士論文 Version none URL http://hdl.handle.net/20.500.12099/81627 ※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。
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Ặ ྡ ຍ ⸨ ᝡ 㑻 㢟 ┠ ࢥ࣮ࣥࢧ࣮ࣞࢪ⤥ࡀங∵ࡢ⏕⏘Ⓨ⏕➨୍⫶ᾮᛶ≧ ࠾ࡼࡧ⫢⤌⧊୰㑇ఏᏊⓎ⌧ཬࡰࡍᙳ㡪㛵ࡍࡿ◊✲ ࢥ࣮ࣥࢧ࣮ࣞࢪ㸦&6㸧ࡣ㸪㧗⃰ᗘࢹࣥࣉࣥࢆࡋࡓ㧗࢚ࢿࣝࢠ࣮㣫ᩱ࡛࠶ࡿࡓࡵ㸪 &6 ⤥ࡣங∵ࡢ➨୍⫶Ⓨ㓝ࢆஹ㐍ࡉࡏ㸪⾑ᾮᛶ≧ࡸἪங㔞ᙳ㡪ࡍࡿࠋ୍᪉㸪&6 ⤥ࡼ ࡾࡀከⓎࡍࡿࡇࡀ▱ࡽࢀ࡚࠸ࡿࡀ㸪ࡑࡢᶵᗎࡘ࠸࡚༑ศ࡞᳨ウࡣ࡞ࡉࢀ࡚࠸࡞࠸ࠋ ࡋࡓࡀࡗ࡚㸪ᮏ◊✲࡛ࡣங∵ࡢ⏕⏘Ⓨ⏕࢚ࢿࣝࢠ࣮௦ㅰཬࡰࡍ &6 ⤥ࡢᙳ㡪ࢆ᫂ࡽ ࡍࡿࡇࢆ┠ⓗࡋࡓࠋ ➨ ❶࡛ࡣ㸪&6 ⤥⏕⏘Ⓨ⏕ࡢ㛵㐃ᛶࢆ᫂ࡽࡍࡿࡓࡵ㸪ᒾᡭ┴ෆࡢ㓗㎰ሙ ࠾ࡅࡿ⏕⏘Ⓨ⏕ᑐࡍࡿせᅉ &6 ⤥ࡢ㛵ࡘ࠸࡚㸪⤫ィᏛⓗᡭἲ௦ㅰࣉࣟࣇ ࣝࢸࢫࢺ㸦037㸧ᡤぢࢆ⏝࠸᳨࡚ドࡋࡓࠋࡑࡢ⤖ᯝ㸪&6 ⤥㓗㎰ሙ㸦Q㸻㸧࡛㠀⤥㓗㎰ ሙ㸦Q㸻㸧ẚ㍑ࡋ࡚㸪ࢣࢺ࣮ࢩࢫ➨ᅄ⫶ኚࡢⓎ⏕⋡ࡀ᭷ព㸦3㸺㸧࡞㧗್ࢆ♧ ࡋࡓࠋࡲࡓ㸪୍⯡⥺ᙧࣔࢹࣝࢆ⏝࠸ࡓⓎ⏕せᅉࡢゎᯒ࡛ࡣ㸪&6 ࢆ≀࡛ ௨ୖྵ ࡴ㣫ᩱ⤥ࡀࢣࢺ࣮ࢩࢫⓎ⏕ࡢࣜࢫࢡせᅉࡋ࡚ྠᐃࡉࢀࡓ㸦࢜ࢵࢬẚ㸻㸪 ಙ㢗༊ 㛫㸻㹼㸪3㸻㸧ࠋࡉࡽ㸪037 ᡤぢ࡛ࡣ &6 ࢆ≀࡛ ௨ୖྵࡴ㣫ᩱࢆ⤥ࡋ࡚ ࠸ࡓ㓗㎰ሙ㸦Q㸻㸧࡛ &6 㠀⤥㓗㎰ሙ㸦Q㸻㸧ẚ㍑ࡋ࡚㸪Ἢஙึᮇ⾑୰ ș ࣄࢻࣟ࢟ ࢩ㓗㓟㸦%+%㸧⃰ᗘࡀ᭷ព㸦3㸺㸧࡞㧗್ࢆ♧ࡋࡓࠋࡇࢀࡽࡢࡇࡽ㸪Ἢஙึᮇࡢங ∵࡛ࡣ㸪&6 ࢆ≀࡛ ௨ୖྵࡴ㣫ᩱ⤥ࡼࡾ㈇ࡢ࢚ࢿࣝࢠ࣮ࣂࣛࣥࢫ㸦1(%㸧ࡀቑᝏࡋ㸪 ࢣࢺ࣮ࢩࢫⓎ⏕ࡢࣜࢫࢡࡀቑຍࡍࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋ ➨ ❶࡛ࡣ㸪&6 ࡢရ✀⤥㔞ࡢᕪ␗ࡀ∵ࡢ➨୍⫶Ⓨ㓝⾑ᾮᛶ≧ཬࡰࡍᙳ㡪ࢆ᫂ࡽ ࡍࡿࡓࡵ㸪ཤໃ∵ࢆ౪ヨࡋ㸪㣫ᩱ୰ࡢ &6 ྜࡀ≀࡛ 㸦 &6 ⩌㸧ࡲࡓࡣ 㸦&6 ⩌㸧ࡢ ⩌༊ศ㸪 ✀㢮ࡢ &6㸦ప⧄⥔ &6 㧗⧄⥔ &6㸧ࢆ⏝࠸࡚㸪 ᮇ 㐌㛫ࡢࢡࣟࢫ࢜ ࣮ࣂ࣮ヨ㦂ࢆᐇࡋ㸪ྛ✀ᛶ≧ࡢゎᯒࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝ㸪ప⧄⥔ &6 ༊࡛ࡣ➨୍⫶ᾮ㓑㓟 ẚ⋡ࡢపୗ࠾ࡼࡧ➨୍⫶ᾮ㓗㓟ẚ⋡⾑୰ %+% ⃰ᗘࡢቑຍࡀࡳࡽࢀ㸪ࡉࡽ㸪 &6 ⩌࡛➨ ୍⫶ᾮࡢ⥲Ⓨᛶ⬡⫫㓟㸦9)$㸧⃰ᗘࡢపୗࣉࣟࣆ࢜ࣥ㓟ẚ⋡ࡢቑຍ㸪⾑୰ࢢࣝࢥ࣮ࢫ㸦*OX㸧 ⥲ࣅࣜࣝࣅࣥ⃰ᗘࡢቑຍ࠾ࡼࡧ⥲ࢥࣞࢫࢸ࣮ࣟࣝ⃰ᗘࡢపୗࡀㄆࡵࡽࢀࡓࠋ୍᪉㸪㧗⧄ ⥔ &6 ༊࡛ࡣ &6 ⤥ࡼࡿࡁ࡞ኚືࡣࡳࡽࢀ࡞ࡗࡓࠋࡇࢀࡽࡢࡇࡽ㸪&6 ⤥ࡼ ࡿ➨୍⫶ᾮ⾑ᾮᛶ≧ࡢᙳ㡪ࡣရ✀⤥㔞ࡼࡾ␗࡞ࡾ㸪➨୍⫶ᾮ 9)$ ࡢ⃰ᗘࡸ⤌ᡂ ࡀኚࡍࡿ⫢⮚࡛ࡢࢣࢺࣥయ⏕ᡂ㸪⢾᪂⏕㸪ࢥࣞࢫࢸ࣮ࣟࣝྜᡂ⬟ࡲࡓࡣࣅࣜࣝࣅ࣭ࣥ ࢡࣜࣛࣥࢫᙳ㡪ࢆཬࡰࡍྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ ➨ ❶࡛ࡣ㸪๓❶࡛♧၀ࡉࢀࡓ &6 ⤥∵ࡢ⫢⮚࠾ࡅࡿ⢾᪂⏕ࢣࢺࣥయ⏕ᡂࡢஹ㐍㸪 ⫢ᶵ⬟పୗࡢᶵᗎࢆ᫂ࡽࡍࡿࡓࡵ㸪๓❶ࡢ౪ヨ∵ࢆ⏝࠸࡚ࣜࣝࢱ࣒ 3&5 ἲࡼࡾ ⫢⤌⧊୰ࡢ௦ㅰ㛵㐃㑇ఏᏊⓎ⌧ࢆゎᯒࡋࡓࠋࡲࡓ㸪ప⧄⥔ &6 ༊ࡢ &6 ⩌࠾࠸࡚⾑୰㐟 㞳࣑ࣀ㓟⃰ᗘࡢ ᐃࢆ㏣ຍࡋࡓࠋࡑࡢ⤖ᯝ㸪&6 ⤥ࡼࡾప⧄⥔ &6 ༊࡛ࡣ &6 ⩌ &6 ⩌ࡢ࠸ࡎࢀࡶ⫢⤌⧊୰ࡢ*3&㸪3&. ࠾ࡼࡧ+0*&/Ⓨ⌧㔞ࡀቑຍࡋ㸪 &6 ⩌࡛ࡣ⾑୰ࣛ ࢽࣥࣇ࢙ࢽࣝࣛࢽࣥ⃰ᗘࡀపୗ㸪ࢢࣜࢩࣥ⃰ᗘࡀቑຍࡋࡓࠋ୍᪉㸪㧗⧄⥔ &6 ༊࡛ࡣ୧ ⩌ࡶ&37$ 33$5$Ⓨ⌧㔞ࡀపୗࡋࡓࠋࡍ࡞ࢃࡕ㸪&6 ⤥ࡼࡾప⧄⥔ &6 ༊࡛ࡣࣉࣟ ࣆ࢜ࣥ㓟ࢆᇶ㉁ࡋࡓ⢾᪂⏕ࢣࢺࣥయ⏕ᡂࡀஹ㐍ࡋ㸪ࡉࡽ㸪 &6 ⩌࡛ࡣ⢾ཎ⏕࣑ࣀ 㓟ࡢ⏝ࡀஹ㐍ࡋࡓ୍᪉㸪㧗⧄⥔ &6 ༊࡛ࡣ࢚ࢿࣝࢠ࣮≧ែࡀᨵၿࡋࡓࡇࡀ♧၀ࡉࢀࡓࠋங∵ࢆ౪ヨࡋ㸪⛣⾜ᮇ࠾ࡅࡿ➨୍⫶ᾮ⾑ᾮࡢᛶ≧࠾ࡼࡧ⫢⤌⧊ࡢ௦ㅰ㛵㐃㑇ఏᏊⓎ ⌧ࢆゎᯒࡋࡓࠋࡑࡢ⤖ᯝ㸪୧⩌ࡶศፔᚋ⾑୰ *OX ⃰ᗘࡀపୗ㸪㐟㞳⬡⫫㓟್ࡀୖ᪼ࡋ ࡓࡀ㸪&6 ⩌࡛ࡣ➨୍⫶ᾮࣉࣟࣆ࢜ࣥ㓟ẚ⋡ࡀపୗ㸪⾑୰ࢣࢺࣥయ⃰ᗘࡀቑຍࡋ㸪⫢⤌⧊୰ ࡢ3&㸪/'+$㸪$&$'9/㸪$&6/࠾ࡼࡧ&37$Ⓨ⌧㔞ࡀቑຍࡋࡓࠋ୍᪉㸪ᑐ↷⩌࡛ࡣ➨୍⫶ᾮ ࣉࣟࣆ࢜ࣥ㓟ẚ⋡⫢⤌⧊୰ࡢ3&.Ⓨ⌧㔞ࡀቑຍࡋࡓࡀ㸪ࡑࡢࡢ㡯┠ࡁ࡞ኚືࡣࡳ ࡽࢀ࡞ࡗࡓࠋࡍ࡞ࢃࡕ㸪&6 ⩌࡛ࡣ➨୍⫶ෆࣉࣟࣆ࢜ࣥ㓟Ⓨ㓝ࡢపୗࡼࡾ 1(% ࡀቑᝏࡋ㸪 ⫢⮚࡛ࡢ ș 㓟ࡀஹ㐍ࡋ࡚⾑୰ࢣࢺࣥయ⃰ᗘࡀቑຍࡋࡓࡇࡀ♧၀ࡉࢀࡓࠋࡇࢀࡽࡢࡇ ࡽ㸪&6 ࢆ≀࡛ ྵࡴ㣫ᩱ⤥ࡣ㸪⛣⾜ᮇங∵ࡢ➨୍⫶Ⓨ㓝ࢆపୗࡉࡏ㸪ศፔᚋࡢ 1(% ࢆቑᝏࡉࡏࡿྍ⬟ᛶࡢ࠶ࡿࡇࡀ♧ࡉࢀࡓࠋ ௨ୖࡢࡼ࠺㸪ᮏ◊✲ࡢ⤖ᯝࡽ㸪&6 ⤥ࡀ∵ࡢ➨୍⫶Ⓨ㓝࢚ࢿࣝࢠ࣮௦ㅰཬࡰࡍ ᙳ㡪ࡣ &6 ࡢရ✀ࡼࡾ␗࡞ࡾ㸪&6 ࢆ≀࡛ ௨ୖྵࡴ㣫ᩱࢆ⤥ࡋࡓሙྜ᫂ࡽ࡞ ࡿ⪃࠼ࡽࢀࡓࠋࡲࡓ㸪⛣⾜ᮇங∵ &6 ࢆ≀࡛ ௨ୖྵࡴ㣫ᩱࢆ⤥ࡍࡿ➨୍⫶Ⓨ 㓝ࡀపୗࡋ㸪⤖ᯝࡋ࡚ 1(% ࢆቑᝏࡉࡏࡿྍ⬟ᛶࡢ࠶ࡿࡇࡀ♧၀ࡉࢀࡓࠋᮏ◊✲ࡼࡗ ࡚ᚓࡽࢀࡓᡤぢࡣ㸪⛣⾜ᮇங∵ࡢ⏕⏘ண㜵ᐤࡍࡿ⪃࠼ࡽࢀࡓࠋ
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