• 検索結果がありません。

自己免疫疾患増悪化におけるα 9 β 1 インテグリンの役割

N/A
N/A
Info
ダウンロード
Protected

Academic year: 2021

シェア "自己免疫疾患増悪化におけるα 9 β 1 インテグリンの役割"

Copied!
1
0
0

読み込み中.... (全文を見る)

今ダウンロードする ( 1 ページ )

全文

(1)

自己免疫疾患増悪化におけるα 9 β 1 インテグリンの役割

今 重之，上出利光＊

J Cell Commun Signal. 12:333-342, 2018.

The role of α9β1 integrin and its ligands in the development of autoimmune diseases.

Kon S, Uede T.

Abstract: Adhesion of cells to extracellular matrix proteins through integrins expressed on the cell surface is important for cell adhesion/motility, survival, and differentiation. Recently, α9β1 integrin was reported to be important for the development of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, and their murine models. In addition, ligands for α9β1 integrin, such as osteopontin and tenascin-C, are well established as key regulators of autoimmune diseases. Therefore, this review focused on the role of interactions between α9β1 integrin and its ligands in the development of autoimmune diseases.

抄録　細胞表面に発現するインテグリンとリガンドである細胞外マトリックスの相互 作用は、細胞増殖や生存、分化に重要な役割をしている。近年、α 9 β 1 インテグリ ンはリウマチ関節炎や多発性硬化症やそれらのマウスモデル等の自己免疫疾患の増悪 化に関与することが当研究室の研究などによって明らかにされている。さらにα 9 β 1 インテグリンのリガンドであるオステオポンチンやテネイシン C なども自己免疫疾 患に関与することから、本論文では、どのようなα 9 β 1 インテグリンと様々なリガ ンドとの相互作用がどのような自己免疫疾患に関与するかを概説した。

＊北海道大学遺伝子病制御研究所

－48－

参照

今ダウンロードする ( PDF - 1 ページ - 788.59 KB )

関連したドキュメント

自然免疫における液性応答と細胞性応答 中西義信

Mechanism of the Cellular Innate Immune Response 1 The pathway for the induction of phagocytosis of microbes is illustrated.. Refer to the text

Molecular investigations of development and diseases of the brain of higher mammals using the ferret

One of the character- istic features of the developing cerebral cortex of higher mammals is the presence of an enlarged SVZ containing an inner region (ISVZ) and an outer region

Pdz adaptors: Their regulation of epithelial transporters and involvement in human diseases

however, expression of OCTN2 on apical membranes of intestinal epithelial cells was.. reduced in pdzk1 -/- mice, compared with wild-type mice, with a concomitant

Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line

However, VPA prevented the morphological changes characteristic for activation and inhibited the expres- sion of collagen type 1 α 1 (COL1A1) and TGF- β 1 in activated LI90 cells

Definition of Hecke Algebras For subsets α, β ⊂G of a groupG, we define α∗ and αβ ⊂G by α∗ ={g−1 :g ∈α} and αβ ={x:∃g ∈α, ∃h ∈β such that x=gh}

The trivial double coset Γ becomes the unit of the Hecke algebra C [Γ\G/Γ].. The proof of the last equality is easy when the vN(H)-separating vector δ Γ is tracial (see [BC] for

JJ II

The concepts of the α-invex and α-preinvex functions have played a very important role in the development of convex programming, see [2, 3]J.

Introduction Forβ >1 a Parry number, Boyd [9] introduced the notion of the beta-conjugates of β in the context of the R´enyi - Parry numeration system

Our aim is to show that their definition can be given in a larger context, namely for any algebraic number β > 1, and that the theory of Puiseux provides a geometric origin to

Investigating Determinants of Multiple Sclerosis in Longitunal Studies: A Bayesian Approach

The random intercept models proposed before may be debatable for fitting repeated measures of weighted change in EDSS, since they underestimate the change for patients, whose