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Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor( 内容と審査の要 旨(Summary) )

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Title Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor( 内容と審査の要 旨(Summary) )

Author(s) 大沼, 隆史

Report No.(Doctoral

Degree) 博士(医学) 甲第1060号

Issue Date 2018-03-25

Type 博士論文

Version ETD

URL http://hdl.handle.net/20.500.12099/75197

※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。

(2)

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⏥➨ ྕ

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ㄽ ᩥ ෆ ᐜ ࡢ せ ᪨

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ࢫࢺࣞࢫࢱࣥࣃࢡ㉁ +HDW 6KRFN 3URWHLQ+63 ࡣࢫࢺࣞࢫᛂ⟅ࡢ㝿࡟ㄏᑟࡉࢀࡿࢱࣥࣃࢡ㉁ࡢ

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⾑ᑠᯈάᛶ໬࡟࠾ࡅࡿ 63 ࡢస⏝ࢆ᫂ࡽ࠿࡜ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ㸪ゎᯒࢆ⾜ࡗࡓࠋ

࠙ᑐ㇟࡜᪉ἲࠚ

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ࣥࢱࢦࢽࢫࢺ㸧࡛๓ฎ⌮ࡋࡓࡢࡕ࡟ࢥ࣮ࣛࢤ่࡛⃭ࣥࡋ㸪ග㏱㐣ἲཬࡧ࣮ࣞࢨ࣮ගᩓ஘ࢩࢫࢸ࣒ࢆ⏝

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࠙⤖ᯝࠚ

(3)

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$% ࡢศἪ㸪V&/ ࡢ㐟㞳㸪ࣜࣥ㓟໬ +63 ࡢ㐟㞳ࢆᢚไࡋࡓࠋ

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࠙⪃ᐹࠚ

63 ࡀࢥ࣮ࣛࢤ่⃭ࣥ࡟ࡼࡿ⾑ᑠᯈจ㞟㸪3'*)$% ศἪ࠾ࡼࡧ V&'/ 㐟㞳ࢆᢚไࡋࡓࡇ࡜࠿ࡽ㸪 63 ࡀࢥ࣮ࣛࢤ่⃭ࣥ࡟ࡼࡿ⾑ᑠᯈάᛶ໬ࢆᢚไࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡲࡓ㸪63 ࡣ S0$3NLQDVH ࡢࣜࣥ㓟໬ࡢᢚไࢆ௓ࡋ࡚ +63 ࡢࣜࣥ㓟໬ࢆᢚไࡍࡿࡇ࡜࡛㸪3'*)$% ࡢศἪ㸪V&'/ ࡢ㐟㞳࠾ࡼ

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࠙⤖ㄽࠚ

ࣄࢺ⾑ᑠᯈ࡟࠾࠸࡚㸪63 ࡣ 635 ࢆ௓ࡋ࡚ࢥ࣮ࣛࢤ่⃭ࣥ࡟ࡼࡿ⾑ᑠᯈจ㞟࠾ࡼࡧ +63 ࡢࣜࣥ

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ࢀࡓࠋ

ㄽ ᩥ ᑂ ᰝ ࡢ ⤖ ᯝ ࡢ せ ᪨

⏦ㄳ⪅ ኱἟ 㝯ྐ ࡣ㸪ࣄࢺᡂ⇍⾑ᑠᯈ࡟࠾࠸࡚㸪ࢫࣇ࢕ࣥࢦ⬡㉁࡛࠶ࡿࢫࣇ࢕ࣥࢦࢩࣥ㸯ࣜ

ࣥ㓟 63 ࡀ 63 ཷᐜయ ࢆ௓ࡋ࡚ࢥ࣮ࣛࢤ่⃭ࣥ࡟ࡼࡿ⾑ᑠᯈจ㞟࠾ࡼࡧ +63 ࡢࣜࣥ㓟໬ࢆᢚ ไࡍࡿࡇ࡜㸪࡞ࡽࡧ࡟⾑ᑠᯈ࠿ࡽࡢ 3'*)$% ࡢศἪ㸪V&'/ ࡢ㐟㞳࠾ࡼࡧࣜࣥ㓟໬ +63 ࡢ㐟㞳ࢆ

ᢚไࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋᮏ◊✲ࡢࡇࢀࡽࡢᡂᯝࡣ㸪⾑ᰦṆ⾑Ꮫ࡞ࡽࡧ࡟㯞㓉⛉ᏛࡢⓎᒎ࡟ᑡ࡞

࠿ࡽࡎᐤ୚ࡍࡿࡶࡢ࡜ㄆࡵࡿࠋ

㹙୺ㄽᩥබ⾲ㄅ㹛

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