spontaneous lung metastasis in a murine osteosarcoma model. Cancer Lett 2008.
Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, et al. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 2008;215:837-45.
Iwata Y, Morihara T, Tachiiri H, Kajikawa Y, Yoshida A, Arai Y, et al. Behavior of host and graft cells in the early remodeling process of rotator cuff defects in a transgenic animal model. J Shoulder Elbow Surg 2008;17:101S-7S.
Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, et al. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. Am J Hum Genet 2008;82:1122-9.
Arai Y, Hara K, Takahashi T, Urade H, Minami G, Takamiya H, et al. Evaluation of the vascular status of autogenous hamstring tendon grafts after anterior cruciate ligament reconstruction in humans using magnetic resonance angiography.
Knee Surg Sports Traumatol Arthrosc 2008;16:342-7.
Arai Y, Hara K, Fujiwara H, Minami G, Nakagawa S, Kubo T. A new arthroscopic-assisted drilling method through the radius in a distal-to-proximal direction for osteochondritis dissecans of the elbow. Arthroscopy 2008;24:237 e1-4.
久保俊一, 藤岡幹浩, 杉山肇, 稲葉裕. 【整形外科における最近の進歩と展望】 骨盤・股関節疾患. 整形外科 2008;59:775-82.
久保俊一, 三上靖夫, 藤岡幹浩. 【"難病"診療の最前線】 骨・関節系疾患"難病"診療の最前線. 京都府立医科大 学雑誌 2008;117:633-9.
藤岡幹浩, 久保俊一. 大腿骨頭壊死の病態と治療. 整形外科 2008;59:1471-9.
上島圭一郎, 藤岡幹浩, 高橋謙治, 堀井基行, 井上重洋, 久保俊一. 【股関節関節唇損傷の診断と治療】 放射状 MRI による寛骨臼関節唇損傷の診断. 整形・災害外科 2008;51:399-405.
上島圭一郎, 藤岡幹浩, 久保俊一. 【下肢荷重関節の最新画像診断】 特発性大腿骨頭壊死症の最新画像診断. 関 節外科 2008;27:706-13.
後藤毅, 藤岡幹浩, 上島圭一郎, 久保俊一. 【リウマチ・膠原病のすべて】 リウマチ・膠原病の合併症 特発性骨壊 死症. からだの科学 2008:151-4.
栗林正明, 藤岡幹浩, 上島圭一郎, 高橋謙治, 平田哲朗, 久保俊一. 【整形外科基礎研究の Up to Date】 ステロイ ド性大腿骨頭壊死症の遺伝子解析. 関節外科 2008;27:257-61.
栗林正明, 藤岡幹浩, 上島圭一郎, 高橋謙治, 平田哲朗, 久保俊一. 分子レベルからみた整形外科疾患 ステロイ ド性大腿骨頭壊死症の遺伝子解析. 整形・災害外科 2008;51:880-1.
分担研究者:高岡邦夫
Masada T, Iwakiri K, Oda Y, Kaneshiro Y, Iwaki H, Ohashi H, et al. Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model. J Orthop Res 2008;26:91-5.
Iwakiri K, Oda Y, Kaneshiro Y, Iwaki H, Masada T, Kobayashi A, et al. Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model. J Orthop Sci 2008;13:463-8.
Minoda Y, Kobayashi A, Sakawa A, Aihara M, Tada K, Sugama R, et al. Wear particle analysis of highly crosslinked polyethylene isolated from a failed total hip arthroplasty. J Biomed Mater Res B Appl Biomater 2008;86B:501-5.
Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K. Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB pathway. J Bone Miner Metab 2008;26:478-84.
Nomura-Furuwatari C, Wakitani S, Hashimoto Y, Imai Y, Ohta Y, Nakagawa K, et al. Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells. J Bone Miner Metab 2008;26:152-8.
Iwakiri K, Iwaki H, Minoda Y, Ohashi H, Takaoka K. Alumina inlay failure in cemented polyethylene-backed total hip arthroplasty. Clin Orthop Relat Res 2008;466:1186-92.
Iwakiri K, Iwaki H, Kobayashi A, Minoda Y, Kagiyama H, Kadoya Y, et al. Characteristics of Hylamer polyethylene particles isolated from peri-prosthetic tissues of failed cemented total hip arthroplasties. J Biomed Mater Res B Appl Biomater 2008;85:125-9.
Hoshino M, Egi T, Terai H, Namikawa T, Kato M, Hashimoto Y, et al. Repair of long intercalated rib defects in dogs using recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and beta-tricalcium phosphate. J Biomed Mater Res A 2008.
Wakitani S, Kawaguchi A, Tokuhara Y, Takaoka K. Present status of and future direction for articular cartilage repair. J Bone Miner Metab 2008;26:115-22.
Uemura T, Kazuki K, Hashimoto Y, Takaoka K. Skiing-induced rupture of the extensor pollicis longus tendon: a report of three cases. Clin J Sport Med 2008;18:292-4.
Nakata N, Kira Y, Yabunaka Y, Takaoka K. Prevention of venous thrombosis by preoperative glycyrrhizin infusion in a rat model. J Orthop Sci 2008;13:456-62.
Minoda Y, Kobayashi A, Iwaki H, Sugama R, Iwakiri K, Kadoya Y, et al. Sagittal alignment of the lower extremity while standing in Japanese male. Arch Orthop Trauma Surg 2008;128:435-42.
Minoda Y, Kobayashi A, Iwaki H, Ohashi H, Takaoka K. TKA Sagittal Alignment with Navigation Systems and Conventional Techniques Vary Only a Few Degrees. Clin Orthop Relat Res 2008.
Kato M, Nakamura H, Terai H, Konishi S, Nagayama R, Takaoka K. Why does delay exist in the diagnosis of intradural spinal cord tumor despite the availability of MRI? J Clin Neurosci 2008;15:880-5.
Kato M, Nakamura H, Suzuki E, Terai H, Wakasa K, Wakasa T, et al. Ependymal cyst in the lumbar spine associated with cauda equina compression. J Clin Neurosci 2008;15:827-30.
Hoshi M, Ieguchi M, Takami M, Aono M, Taguchi S, Kuroda T, et al. Clinical problems after initial unplanned resection of sarcoma. Jpn J Clin Oncol 2008;38:701-9.
分担研究者:廣田良夫
Shibatani M, Fujioka M, Arai Y, Takahashi K, Ueshima K, Okamoto M, et al. Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral head.
Acta Orthop 2008;79:631-6.
Motomura G, Yamamoto T, Miyanishi K, Kondo K, Hirota Y, Iwamoto Y. Risk Factors for Developing Osteonecrosis After Prophylaxis in Steroid-treated Rabbits. J Rheumatol 2008.
Kuribayashi M, Fujioka M, Takahashi KA, Arai Y, Hirata T, Nakajima S, et al. Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head. J Orthop Sci 2008;13:297-303.
Tanaka K, Miyake Y, Sasaki S, Ohya Y, Matsunaga I, Yoshida T, et al. Beverage consumption and the prevalence of tooth loss in pregnant Japanese women: the Osaka Maternal and Child Health Study. Fukuoka Igaku Zasshi 2008;99:80-9.
Tanaka K, Miyake Y, Sasaki S, Ohya Y, Hirota Y. Maternal smoking and environmental tobacco smoke exposure and the risk of allergic diseases in Japanese infants: the Osaka Maternal and Child Health Study. J Asthma 2008;45:833-8.
Ohfuji S, Fukushima W, Tanaka T, Habu D, Takeda T, Tamori A, et al. Does a late evening meal reduce the risk of hepatocellular carcinoma among patients with chronic hepatitis C? Hepatol Res 2008;38:860-8.
Murakami K, Miyake Y, Sasaki S, Tanaka K, Yokoyama T, Ohya Y, et al. Dietary glycemic index and load and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study. J Affect Disord 2008;110:174-9.
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Epidemiol 2008;18:78-84.
Hirota Y, Kaji M. History of influenza vaccination programs in Japan. Vaccine 2008;26:6451-4.
Hirota Y, Fukushima W, Fujieda M, Ohfuji S, Maeda A. Essential tools for assessing influenza vaccine efficacy in improperly conducted studies: A Japanese perspective. Vaccine 2008;26:6455-8.
Hirota Y. Ecological fallacy and scepticism about influenza vaccine efficacy in Japan: The Maebashi Study. Vaccine 2008;26:6473-6.
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Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, et al. Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): part 4. Establishment of equations for severity scores.
Subcommittee on low back pain and cervical myelopathy, evaluation of the clinical outcome committee of the Japanese Orthopaedic Association. J Orthop Sci 2008;13:25-31.
Fukui M, Chiba K, Kawakami M, Kikuchi S, Konno S, Miyamoto M, et al. Japanese Orthopaedic Association Back Pain Evaluation Questionnaire. Part 3. Validity study and establishment of the measurement scale : Subcommittee on Low Back Pain and Cervical Myelopathy Evaluation of the Clinical Outcome Committee of the Japanese Orthopaedic Association, Japan. J Orthop Sci 2008;13:173-9.
分担研究者:進藤裕幸
Okano K, Enomoto H, Osaki M, Takahashi K, Shindo H. Femoral head deformity after open reduction by Ludloff's medial approach. Clin Orthop Relat Res 2008;466:2507-12.
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a first case in Japan. Skeletal Radiol 2008;37:563-7.
Suzuki M, Kumagai K, Osaki M, Murata M, Tomita M, Miyata N, et al. Osteonecrosis of Femoral Head in the Stroke Prone Spontaneously Hypertensive Rats ‒Especially in Old Rats. Clinical and Experimental Hypertension (in press) Shindo H, Chigira H, Tanaka J, Kamatani N, Inoue M. Grouping preprocess to accurately extend application of EM algorithm to haplotype inference. J Hum Genet 2008;53:747-56.
Okano K, Takaki M, Okazaki N, Shindo H. Bilateral incidence and severity of acetabular dysplasia of the hip. J Orthop Sci 2008;13:401-4.
Okano K, Kawahara N, Chiba K, Shindo H. Radiographic joint space width in patients with Crowe Type-I dysplastic hips.
Clin Orthop Relat Res 2008;466:2209-16.
Okano K, Enomoto H, Osaki M, Shindo H. Rotational acetabular osteotomy with excision of the capital drop for advanced osteoarthritis secondary to developmental dysplasia of the hip. Arch Orthop Trauma Surg 2008;128:1117-22.
Okano K, Enomoto H, Osaki M, Shindo H. Outcome of rotational acetabular osteotomy for early hip osteoarthritis secondary to dysplasia related to femoral head shape: 49 hips followed for 10-17 years. Acta Orthop 2008;79:12-7.
Okano K, Enomoto H, Osaki M, Shindo H. Joint Congruency as an Indication for Rotational Acetabular Osteotomy.
Clin Orthop Relat Res 2008.
尾崎誠, 穂積晃, 進藤裕幸. 整形トピックス 内分泌器官としての骨髄脂肪細胞の研究. 整形外科 2008;59(1):46.
分担研究者:長澤浩平
Mitamura M, Tada Y, Koarada S, Inoue H, Suematsu R, Ohta A, et al. Cyclosporin A treatment for Japanese patients
with severe adult-onset Still's disease. Mod Rheumatol 2008.
Hayashi S, Tanaka M, Kobayashi H, Nakazono T, Satoh T, Fukuno Y, et al. High-resolution computed tomography characterization of interstitial lung diseases in polymyositis/dermatomyositis. J Rheumatol 2008;35:260-9.
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Tada Y, Koarada S, Morito F, Mitamura M, Inoue H, Suematsu R, et al. Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis. Arthritis Res Ther 2008;10:R121.
Tada Y, Fukuoka M, Mitamura M, Koarada S, Suematsu R, Inoue H, et al. Nocardiosis in adult-onset Still's disease and vasculitis syndrome. Am J Med Sci 2008;336:77-80.
Koarada S, Tsuneyoshi N, Haruta Y, et al.: Effect of disease activity and corticosteroids on serum levels of soluble endothelial cell protein C receptor in patients with systemic lupus erythematosus. Mod Rheumatol in press.
分担研究者:松野丈夫
Katayama K, Matsuno T. Effects of bisphosphonates on fracture incidence and bone metabolism in rheumatoid arthritis patients in general practice taking long-term corticosteroid therapy: a retrospective study. Clin Drug Investig 2008;28:149-58.
Tanino H, Ito H, Harman MK, Matsuno T, Hodge WA, Banks SA. An in vivo model for intraoperative assessment of impingement and dislocation in total hip arthroplasty. J Arthroplasty 2008;23:714-20.
Jimbo S, Atsuta Y, Kobayashi T, Matsuno T. Effects of dry needling at tender points for neck pain (Japanese: katakori):
near-infrared spectroscopy for monitoring muscular oxygenation of the trapezius. J Orthop Sci 2008;13:101-6.
Ito H, Matsuno T, Hirayama T, Tanino H, Yamanaka Y, Minami A. Three-dimensional computed tomography analysis of non-osteoarthritic adult acetabular dysplasia. Skeletal Radiol 2008.
分担研究者:松本俊夫
Yagi S, Aihara K, Ikeda Y, Sumitomo Y, Yoshida S, Ise T, et al. Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency.
Circ Res 2008;102:68-76.
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Miyauchi A, Matsumoto T, Shigeta H, Tsujimoto M, Thiebaud D, Nakamura T. Effect of teriparatide on bone mineral density and biochemical markers in Japanese women with postmenopausal osteoporosis: a 6-month dose-response study.
J Bone Miner Metab 2008;26:624-34.
Yagi S, Akaike M, Fujimura M, Ise T, Yoshida S, Sumitomo Y, et al. Infective endocarditis caused by lactobacillus.
Intern Med 2008;47:1113-6.
Wang W, Nishioka Y, Ozaki S, Jalili A, Verma VK, Hanibuchi M, et al. Chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells. Lung Cancer 2008.
Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, et al. Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement.
Bone 2008;42:1235-9.
Wang W, Nishioka Y, Ozaki S, Jalili A, Abe S, Kakiuchi S, et al. HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody. Cancer Immunol Immunother 2008.
Kawai S, Azuma Y, Fujii E, Furugaki K, Ozaki S, Matsumoto T, et al. Interferon-alpha enhances CD317 expression and
the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models. Cancer Sci 2008.
Fukumoto S, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, et al. Causes and differential diagnosis of hypocalcemia--recommendation proposed by expert panel supported by ministry of health, labour and welfare, Japan.
Endocr J 2008;55:787-94.
Yata K, Abe M, Matsumoto T. [Mechanisms for formation of myeloma bone disease]. Clin Calcium 2008;18:438-46.
Endo I, Matsumoto T. [Bisphosphonate and mechanical stress on bone]. Clin Calcium 2008;18:1321-6.
分担研究者:松本忠美
Kabata T, Matsumoto T, Yagishita S, Wakayama T, Iseki S, Tomita K. Vascular Endothelial Growth Factor in Rabbits During Development of Corticosteroid-Induced Osteonecrosis: A Controlled Experiment. J Rheumatol 2008.
Kimura H, Kaneuji A, Sugimori T, Matsumoto T. Revision total hip arthroplasty by nonmodular short and long cementless stems. J Orthop Sci 2008;13:335-40.
分担研究者:渥美敬
Nakajima T, Izumizaki M, Sekihara C, Atsumi T, Homma I. Combined effects of preceding muscle vibration and contraction on the tonic vibration reflex. Exp Brain Res 2009;192:211-9.
Atsumi T. [Bone disease with Pain. Non-traumatic osteonecrosis of the femoral head]. Clin Calcium 2008;18:1183-92.
渥美 敬, 山野賢一, 柁原俊久, 武村 康, 平沼泰成, 玉置 聡, 朝倉靖弘, 中西亮介, 加藤英治, 渡辺 実, 小原 周. 発育期大腿骨頭の壊死性病変への応用 思春期の高度圧潰広範囲大腿骨頭壊死に対する大腿骨頭高度後方 回転骨切り術. 臨床整形外科 2008; 43(10):989-996.
分担研究者:岩本幸英
Nishida K, Yamamoto T, Motomura G, Jingushi S, Iwamoto Y. Pitavastatin may reduce risk of steroid-induced osteonecrosis in rabbits: a preliminary histological study. Clin Orthop Relat Res 2008;466:1054-8.
Motomura G, Yamamoto T, Miyanishi K, Kondo K, Hirota Y, Iwamoto Y. Risk Factors for Developing Osteonecrosis After Prophylaxis in Steroid-treated Rabbits. J Rheumatol 2008.
Motomura G, Yamamoto T, Irisa T, Miyanishi K, Nishida K, Iwamoto Y. Dose Effects of Corticosteroids on the Development of Osteonecrosis in Rabbits. J Rheumatol 2008.
Miyanishi K, Yamamoto T, Irisa T, Yamashita A, Motomura G, Jingushi S, et al. Effects of tacrolimus (FK506) on the development of osteonecrosis in a rabbit model. Immunopharmacol Immunotoxicol 2008;30:79-90.
Yamamoto T, Schneider R, Iwamoto Y, Bullough PG. Histopathologic prevalnece of subchondral insufficiency fracture of the femoral head.Ann Rheum Dis 2008; 67: 150-3.
Miyanishi K, Hara T, Kaminomachi S, Maeda H, Watanabe H, Torisu T.Contrast-enhanced MR imaging of subchondral insufficiency fracture of the femoral head: a preliminary comparison with that of osteonecrosis of the femoral head.Arch Orthop Trauma Surg. 2008 in press
Ikemura S, Yamamoto T, Jingushi S, Nakashima Y, Mawatari T, Iwamoto Y. Recurrent Transient Osteoporosis of the Hip. Eur J Radiol Extra. 2008; 66: e65-e69.
Matsushita A, Nakashima Y, Jingushi S, Yamamoto T, Kuraoka A, Iwamoto Y. Effects of the Femoral Offset and the Head Size on the Safe Range of Motion in Total Hip Arthroplasty. J Arthroplasty 2008.
Yoshida T, Sakamoto A, Iwamoto Y. Vascularized Iliac Bone Graft in Cases of Ankle Tuberculosis. J Reconstr Microsurg 2008.
Yamamoto S, Tanaka K, Sakimura R, Okada T, Nakamura T, Li Y, et al. Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines. Anticancer Res 2008;28:1585-91.
Ueda T, Naka N, Araki N, Ishii T, Tsuchiya H, Yoshikawa H, et al. Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study. J Orthop Sci 2008;13:304-12.
Tashiro Y, Miura H, Nakanishi Y, Okazaki K, Iwamoto Y. Evaluation of Skills in Arthroscopic Training Based on Trajectory and Force Data. Clin Orthop Relat Res 2008.
Takenaka S, Ueda T, Naka N, Araki N, Hashimoto N, Myoui A, et al. Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan. Oncol Rep 2008;19:467-76.
Sakamoto A, Yoshida T, Uchida Y, Kojima T, Kubota H, Iwamoto Y. Long-term follow-up on the use of vascularized fibular graft for the treatment of congenital pseudarthrosis of the tibia. J Orthop Surg 2008;3:13.
Sakamoto A, Tanaka K, Yoshida T, Iwamoto Y. Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther 2008;38:434-8.
Sakamoto A, Jono O, Hirahashi M, Oya M, Iwamoto Y, Arai K. Epithelioid sarcoma with muscle metastasis detected by positron emission tomography. World J Surg Oncol 2008;6:84.
Sakamoto A, Iwamoto Y. Current status and perspectives regarding the treatment of osteo-sarcoma: chemotherapy.
Rev Recent Clin Trials 2008;3:228-31.
Okada A, Mochizuki S, Yatabe T, Kimura T, Shiomi T, Fujita Y, et al. ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage. Arthritis Rheum 2008;58:778-89.
Oda Y, Kohashi K, Yamamoto H, Tamiya S, Kohno K, Kuwano M, et al. Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma. Cancer Sci 2008;99:726-32.
Moro-oka TA, Hamai S, Miura H, Shimoto T, Higaki H, Fregly BJ, et al. Dynamic activity dependence of in vivo normal knee kinematics. J Orthop Res 2008;26:428-34.
Mizu-Uchi H, Matsuda S, Miura H, Higaki H, Okazaki K, Iwamoto Y. Three-dimensional Analysis of Computed Tomography-Based Navigation System for Total Knee Arthroplasty The Accuracy of Computed Tomography-Based Navigation System. J Arthroplasty 2008.
Miura H, Takasugi SI, Kawano T, Manabe T, Iwamoto Y. Varus-valgus laxity correlates with pain in osteoarthritis of the knee. Knee 2008.
Mawatari T, Miura H, Hamai S, Shuto T, Nakashima Y, Okazaki K, et al. Vertebral strength changes in rheumatoid arthritis patients treated with alendronate, as assessed by finite element analysis of clinical computed tomography scans:
A prospective randomized clinical trial. Arthritis Rheum 2008;58:3340-9.
Matono H, Oda Y, Nakamori M, Tamiya S, Yamamoto H, Yokoyama R, et al. Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors. Hum Pathol 2008;39:1802-8.
Kohashi K, Izumi T, Oda Y, Yamamoto H, Tamiya S, Taguchi T, et al. Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor. Hum Pathol 2008.
Imamura T, Imamura C, McAlinden A, Davies SR, Iwamoto Y, Sandell LJ. A novel tumor necrosis factor alpha-responsive CCAAT/enhancer binding protein site regulates expression of the cartilage-derived retinoic acid-sensitive protein gene in cartilage. Arthritis Rheum 2008;58:1366-76.
Hamai S, Miura H, Higaki H, Matsuda S, Shimoto T, Sasaki K, et al. Kinematic analysis of kneeling in cruciate-retaining and posterior-stabilized total knee arthroplasties. J Orthop Res 2008;26:435-42.
Akasaki Y, Matsuda S, Shimoto T, Miura H, Higaki H, Iwamoto Y. Contact stress analysis of the conforming post-cam mechanism in posterior-stabilized total knee arthroplasty. J Arthroplasty 2008;23:736-43.
Mawatari T, Miura H, Iwamoto Y, Higaki H. [Assessment of bone quality. Effects of osteoporosis medications on structural and mechanical integrity of bone]. Clin Calcium 2008;18:354-63.
分担研究者:吉村了勇
Shibatani M, Fujioka M, Arai Y, Takahashi K, Ueshima K, Okamoto M, et al. Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral head.
Acta Orthop 2008;79:631-6.
Kuribayashi M, Fujioka M, Takahashi KA, Arai Y, Hirata T, Nakajima S, et al. Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head. J Orthop Sci 2008;13:297-303.
Wakabayashi Y, Tsujimura A, Matsuda K, Yoshimura N, Kawata M. Appearance of LFA-1 in the initial stage of synaptogenesis of developing hippocampal neurons. Arch Histol Cytol 2008;71:23-36.
Akioka K, Okamoto M, Ushigome H, Nobori S, Kaihara S, Yoshimura N. BK virus-associated nephropathy in a kidney transplant recipient successfully treated with cidofovir, the first case in Japan. Int J Urol 2008;15:369-71.
分担研究者:佛淵孝夫
Sonohata M, Akiyama T, Fujita I, Asami A, Mawatari M, Hotokebuchi T. Neonate with calcinosis cutis following extravasation of calcium gluconate. J Orthop Sci 2008;13:269-72.
Noda I, Miyaji F, Ando Y, Miyamoto H, Shimazaki T, Yonekura Y, et al. Development of novel thermal sprayed antibacterial coating and evaluation of release properties of silver ions. J Biomed Mater Res B Appl Biomater 2008.
分担研究者:遠藤直人
Sato T, Ito T, Hirano T, Morita O, Kikuchi R, Endo N, et al. Low back pain in childhood and adolescence: a cross-sectional study in Niigata City. Eur Spine J 2008;17:1441-7.
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Ohashi M, Ito T, Hirano T, Endo N. Percutaneous intralesional injection of calcitonin and methylprednisolone for treatment of an aneurysmal bone cyst at C-2. J Neurosurg Pediatrics 2008;2:365-9.
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分担研究者:田中良哉
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分担研究者:安永裕司
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分担研究者:大園健二
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分担研究者:神宮司誠也
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分担研究者:菅野伸彦
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Hayaishi Y, Miki H, Yoshikawa H, Sugano N. Phase transformation of a new generation yttria-stabilized zirconia femoral head after total hip arthroplasty. Mod Rheumatol 2008.
Hananouchi T, Nakamura N, Kakimoto A, Yohsikawa H, Sugano N. CT-based planning of a single-radius femoral component in total knee arthroplasty using the ROBODOC system. Comput Aided Surg 2008;13:23-9.
分担研究者:田中 栄
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分担研究者:山路 健
Yamaji K, Kim YJ, Tsuda H, Takasaki Y. Long-term clinical outcomes of synchronized therapy with plasmapheresis and intravenous cyclophosphamide pulse therapy in the treatment of steroid-resistant lupus nephritis. Ther Apher Dial 2008;12:298-305.
分担研究者:藤岡幹浩
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特発性大腿骨頭壊死症の関連要因に関する系統的レビュー（続報）
阪口元伸、福島若葉、廣田良夫 （大阪市立大学大学院医学研究科公衆衛生学）
新たな多施設共同症例・対照研究の実施に向けて、検討すべき要因を明確化するため、特発性大腿骨頭 壊死症（ION）の関連要因に関する過去の報告について系統的レビューを行った。
2007 年 6 月 29 日時点で PubMed に登録されていた論文から検索を行い、考慮すべき論文 109 編を選定し
た。このうち、「総ての ION、あるいは非ステロイド性 ION」の関連要因に関するレビュー結果は平成 19 年度
に報告済みである。今年度は、「ステロイド性 ION」に限定して関連要因を検討した論文 35 編についてレビュ ーを行った。
報告の多くは、膠原病（SLE など）や腎移植患者を対象としていた。以下、研究デザイン毎に概要を述べる。
比較研究は１７編であった。約半数の研究がステロイド剤の投与量・投与法を評価しており、1 日投与量、累 積投与量、パルス療法有りで正の関連が報告されていた。その他の臨床情報で ION と正の関連が示唆され たものは、腎移植患者では移植後の拒絶反応や GVHD（移植片対宿主病）の出現、SLE 患者では中枢神経 系症状、偏頭痛、レイノー現象の存在であった。バイオマーカーでは、apolipoprotein(a)の低分子量、血清総 コレステロール高値、白血球数高値、アルブミン高値、あるいはミダゾラムクリアランス低値で ION のリスク上昇 が報告されていた。遺伝子関連では、ABCB1 及び apolipoprotein B の多型との関連が示唆されていた。
比較群を有しない観察研究、記述研究、および症例集積は１５編であった。腎移植、骨髄移植、急性リンパ 性白血病、自己免疫性疾患等に対してステロイド治療を受けた患者を対象に、ION の発生頻度が調査されて いた。また、40 歳未満の ION 発生頻度が高いとする報告や、ステロイドとスタチンの併用投与により ION の発 生が低下することを示唆する報告もあった。
症例報告 3 編のうち、慢性の顔面湿疹に対して長期にわたり局所ステロイドを使用していた患者に発生した 大腿骨頭壊死症が 1 例報告されていた。
現在、昨年度と今年度のレビュー結果をもとに、研究計画の立案および疫学情報・臨床情報の収集フォー ムの作成を進めている。
1．研究目的
本研究班では、特発性大腿骨頭壊死症（ION）の発 生要因解明を目的とした多施設共同症例・対照研究を 過去 3 回にわたり実施してきた。第 1 回目の研究では、
ステロイド全身投与歴を有しない ION 患者を症例とし、
飲酒および喫煙の即時効果と累積効果を明らかにした。
1) 第 2 回目は、SLE 患者あるいは腎移植患者を対象と してステロイド投与量・投与法の影響を詳細に検討し、1 日平均投与量で最も鮮明な関連を認めることを示した。
2-4) 現在データ解析中の第 3 回目の研究では、誘因に
かかわらず、総ての ION 患者を症例とすることで「ステ ロイド非投与に対する投与のリスク」を算出し、そのイン
5)
一方、本研究班で運営している定点モニタリングシス テム、あるいは 2005 年実施の全国疫学調査の集計結 果によると、ステロイド全身投与歴およびアルコール多 飲歴の両者を有しない症例が 10%程度報告されている。
6,7) しかし現状では、ステロイド・アルコール以外の要因
の影響について、十分な論拠が蓄積されていない。
以上の背景を考慮し、研究班として実施する第４回 目の多施設共同症例・対照研究を計画している。新た な研究ではステロイド・アルコール以外の要因も幅広く 調査することを予定しているため、検討すべき要因を明 確化する必要がある。
今回、研究計画の立案に先立ち、ION の関連要因に
レビューを実施した。なお、「総ての ION、あるいは非 ステロイド性 ION」の関連要因に関するレビュー結果は
昨年度に報告済みである。8）今年度は、「ステロイド性
ION」に限定して関連要因を検討した論文についてレビ ューを行ったので、その結果を報告する。
2．研究方法
2007 年 6 月 29 日時点で PubMed に登録されていた 論文から検索を行った。Keyword は、[osteonecrosis AND femoral head AND (epidemiology OR risk OR characteristic)] とし、English で制限した。期間の制限 は行わなかった。
検索された論文のうち、Title および Abstract から考 慮すべきものを選定し、内容を一定のフォームにまとめ た。
3．研究結果
検索された論文は 452 編であった。このうち、①大腿 骨頭壊死症に関する論文ではないもの、②動物実験に よるもの、③病理所見、画像所見、治療、予後に関する もの、④対象者が症候性（二次性）大腿骨頭壊死症患 者であるもの、を除外した 109 編をレビューの対象とし た。
109 編の論文は、主たる研究目的に基づき、①総て の ION、あるいは非ステロイド性 ION の関連要因を検討 したもの（70 編、うち 19 編が総説）、②ステロイド性 ION に限定して関連要因を検討したもの（39 編、うち 3 編が 総説、1 編が comment to authors）、の 2 種類に大別し た。本年度は、後者のうち、総説および comment to authors を除く 35 編についてレビューを行った。
報告の多くは、膠原病（SLE など）や腎移植患者を対 象としていた。以下、研究デザイン毎に概要を述べる。
1）比較研究：17 編 （Table 1）
基本特性として、男性、アフリカ系アメリカ人でリスク 上昇が報告されていた。年齢については、一貫した関 連を認めなかった。
約半数の研究がステロイド剤の投与量・投与法を評 価しており、1 日投与量、累積投与量、パルス療法有り について正の関連が報告されていた。その他の臨床情 報で ION と正の関連が示唆されたものは、腎移植患者 では移植後の拒絶反応や GVHD（移植片対宿主病）の 出現、SLE 患者では中枢神経系症状、偏頭痛、レイノ
バイオマーカーでは、apolipoprotein(a)の低分子量、
血清総コレステロール高値、白血球数高値、アルブミン 高値、あるいはミダゾラムクリアランス低値で ION のリス ク上昇が報告されていた。遺伝子関連では、ABCB1 及 び apolipoprotein B の多型との関連が示唆されていた。
その他、腎移植時にステロイドと併用する免疫抑制 剤に着目し、シクロスポリン A と比較してタクロリムスの 使用が有意に ION の発生を減少させるという報告があ った。
2）比較群を有しない観察研究、記述研究、および症例 集積：15 編 （Table 2）
腎移植、骨髄移植、急性リンパ性白血病、自己免疫 性疾患等に対してステロイド治療を受けた患者を対象 に、ION の発生頻度が調査されていた。また、40 歳未 満の ION 発生頻度が高いとする報告や、ステロイドとス タチンの併用投与によりIONの発生が低下することを示 唆する報告もあった。
3）症例報告：3 編 （Table 3）
放射線肺炎、精巣腫瘍、慢性の顔面湿疹に対するス テロイド治療に関連すると考えられた ION 症例が報告さ れていた。そのうち、慢性の顔面湿疹に関する論文で は、2 年 10 ヵ月の長期にわたり局所ステロイドを使用し た患者に大腿骨頭壊死が発生していた。当該患者はそ の他のリスク要因を有していなかったため、局所ステロ イドに関連した大腿骨頭壊死症例と考えられると報告さ れていた。
4．考察および結論
昨年度と今年度のレビューにより、新たな症例・対照 研究で検討すべき要因を把握することができた。
今後、これらの結果をもとに、研究計画の立案および 疫学情報・臨床情報の収集フォームの作成を進める。
5．研究発表 1． 論文発表
なし 2． 学会発表 なし
6．知的所有権の取得状況 １． 特許の取得
2. 実用新案登録 なし
3． その他 なし
7．参考文献
1) Hirota Y, Hirohata T, Fukuda K, et al.: Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head. Am J Epidemiol.
137: 530-538, 1993.
2) Hirota Y, Hotokebuchi T, Sugioka Y: Idiopathic osteonecrosis of the femoral head; nationwide epidemiologic studies in Japan. Osteonecrosis- Etiology, Diagnosis and Treatment, ed. by Urbaniak JR and Jones JP Jr, American Academy of Orthopaedic Surgeons, Rosemont, Illinois, pp 51-58, 1997.
3) 廣田良夫, 竹下節子, 杉岡洋一, ほか：ステロイド の種々投与法と特発性大腿骨頭壊死症との関連
―SLE 患者における症例・対照研究. 厚生省特定 疾患特発性大腿骨壊死症調査研究班平成 7 年度 研究報告書, 17〜22 頁, 1996.
4) 廣田良夫, 佛淵孝夫, 竹下節子, ほか：ステロイド 性大腿骨頭壊死症の発生要因―腎移植患者にお ける症例・対照研究. 厚生省特定疾患骨・関節系 疾患調査研究班平成 10 年度研究報告書, 169〜
174 頁, 1999.
5) 廣田良夫、田中隆、福島若葉、阪口元伸：特発性
大腿骨頭壊死症の発生要因―多施設共同症例・
対照研究―．厚生労働科学研究費補助金 難治 性疾患克服研究事業 特発性大腿骨頭壊死症調 査研究班 平成 16〜18 年度総合研究報告書, 23
〜28 頁, 2007.
6) 福島若葉, 廣田良夫, 藤岡幹浩, ほか：特発性大 腿骨頭壊死症の全国疫学調査―最終結果―. 厚 生労働科学研究費補助金難治性疾患克服研究事 業 特発性大腿骨頭壊死症の予防と治療の標準化 を目的とした総合研究 平成 18 年度総括・分担研 究報告書, 1〜6 頁, 2007.
7) 福島若葉, 田中 隆, 竹下節子, 廣田良夫, ほか．
定点モニタリングによる特発性大腿骨頭壊死症の 記述疫学研究―新患症例に関する 8 年間の集計・
費補助金 難治性疾患克服研究事業 特発性大腿 骨頭壊死症の予防と治療の標準化を目的とした総 合研究 平成 16 年度総括・分担研究報告書, 6〜
10 頁, 2005.
8) 福島若葉、阪口元伸、廣田良夫：特発性大腿骨頭
壊死症の関連要因に関する系統的レビュー（中間 報告）．厚生労働科学研究費補助金 難治性疾患 克服研究事業 特発性大腿骨頭壊死症調査研究 班 平成 19 年度総括・分担研究報告書, 1〜17 頁, 2008.
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Table 1. Previous studies in relation to associated factors for steroidal ONFH (ONFH: osteonecrosis of the femoral head) Study design: Comparison studies
Ref. No. Authors/Year/Country
Study Design/Year/
Follow-up period
Subjects (M:male, F:female) Mean (or median)
age Main result
1 Hirata, et al Case-control Case:34 (M:22/F:12) 39.5 Variables OR (95%CI)
2007 1983-2004 following renal transplantation and steroid use apolipoprotein B (C7623T)
Japan Control:124 (M:91/F:33) 35.0 CT TT (vs CC) 6.37 (1.53 - 26.5)
following renal transplantation and steroid use apolipoprotein B (G12619A)
GA AA (vs GG) 0.55 (0.06 - 5.11)
apolipoprotein A1 (G-75A)
GA AA (vs GG) 1.41 (0.57 - 3.50)
apolipoprotein A1 (C83T)
CT TT (vs CC) 1.39 (0.39 - 5.05)
Variables P value
HDL 0.161
LDL 0.470
LD/HDL ratio 0.227
2 Hedri, et al Case-control Case:15 (M:11/F:4) 40.8 Variables P value
2007 1986-2004 following renal transplantation and steroid use Duration of dialysis (year) NS
Tunisia Control:15 38.3 Mean rate of acute rejection episodes 0.058
following renal transplantation and steroid use Cumulative mean dose of glucocorticoid 0.04
mached for age, gender, Weight gain at 1 year after RT NS
date of renal transplantation Serum creatinine NS
3 Hirata, et al Case-control Case: 20 (gender ratio: unknown) unknown Variables OR (95%CI)
2007 1983-2004 following renal transplantation Molecular weight phenotype of apolipoprotein A
Japan Control: 92 (gender ratio: unknown) unknown LMW (vs HMW) 5.75 (1.76 - 18.74)
following renal transplantation (unmatched)
4 Kaneshiro, et al Case-control Case: 26 (M: 53.8%) 44.5±13.7 Variables OR (95%CI)
2006 2002-2006 Control: 75 (M: 42.6%) 43.4±14.7 Midazolam clearance
Japan unmatched <=9.5mL kg-1 min-1 (vs >9.5mL kg-1 min-1) 9.08 (2.79 - 29.6)
Table 1 continues
Table 1. (continued)
Ref. No. Authors/Year/Country
Study Design/Year/
Follow-up period
Subjects (M:male, F:female) Mean (or median)
age Main result
5 Talamo, et al Case-control Case: 49 (M:38/F:11) 52.0 (SD:8.6) Variables OR (95%CI)
2005 1998- with myeloma and dexamethasone treatment Younger age 0.962 (0.934 - 0.991)
US Control: 504 (M:290/F:214) 58.0 (SD:9.85) Female 0.392 (0.196 - 0.785)
unmatched Larger steroid dose unit/40mg 1.028 (1.013 - 1.044)
6 Nagasawa, et al Case-control 60 newly diagnosed SLE patients requiring
2006 1993-1998 steroid therapy 30.2 (13 - 56)
Japan Warfarin (+) group: 31 (M:2/F:29) 29.8 (15 - 50) Variables P value
Warfarin (-) group: 29 (M:3/F:26) Male <0.05
↓ 30.8 Steoid pulse therapy <0.001
Case: 18 (M:4/F:14) 29.7 CNS disease <0.05
Non-case: 42 (M:1/F:41)
7 Nagasawa, et al Case-control Case: 15 (M:2/F:13) 29.1 Variables P value
2005 1994-1997 with SLE and high dose steroid therapy Steoid pulse therapy (+) <0.05
Japan (>5yrs follow-up) Control: 30 (F:30) 31.1 Total cholesterol ↑ <0.05
with SLE and high dose steroid therapy WBC ↑ <0.05
Albumin ↑ <0.05
8 Asano, et al Case-control Case: 31 (M:20/F:11) 38.6 Variables OR (95%CI)
2004 1970- after renal transplantation PAI-1 genotype
Japan Control: 106 (M:79/F:27) 36.5 4G/5G (vs 5G/5G) 0.65 (0.17 - 2.47)
after renal transplantaiton 4G/4G (vs 5G/5G) 1.81 (0.48 - 6.78)
unmatched MTHFR genotype
CT (vs CC) 0.52 (0.20 - 1.39)
TT (vs CC) 0.96 (0.30 - 3.08)
9 Inoue, et al Case-control Case: 18 (M:11/F:7) 33.8 (20.4-56.2) Variables OR (95%CI)
2003 1983-1992 after renal transplantation BUN >= two-fold rise 2.17 (0.67 - 7.03)
Japan Control: 72 (M:51/F:21) 32.8 (19.0-61.2) Steroid daily dosage >= 25.0mg 7.06 (0.36 - 13.8)
after renal transplantation matched for age and gender
Table 1 continues
Table 1. (continued)
Ref. No. Authors/Year/Country
Study Design/Year/
Follow-up period
Subjects (M:male, F:female) Mean (or median)
age Main result
10 Sakai, et al Cohort Cyclosporin A: 32 (M:21/F:11) 35.1±9.4 Osteonecrosis: 5 P value
2003 - Tacrolimus: 32 (M:21/F:11) 35.3±10.1 Osteonecrosis: 0 0.026
Japan matched for age, gender, and renal allograft
11 Asano, et al Case-control Case: 30 (M:20/F:10) 40.5 (25-63) Variables OR (95%CI)
2003 1970- after renal transplantation ABCB1 genotype
Japan Control: 106 (M:78/F:28) 36.2 (9-62) 3435TT (vs 3435CC or CT) 0.10 (0.01 - 0.84)
after renal transplantation 2677(TorA)(TorA) (vs 2677GG or G(TotA)) 0.30 (0.09 - 0.98)
12 Asano, et al Case-control Case: 26 (gender ratio: unknown) unknown Variables OR (95%CI)
2003 1970- after renal transplantation CYP2D6
Japan Control: 54 (gender ratio: unknown) unknown IM (vs EM) 1.8 (0.4 - 7.9)
after renal transplantation CYP2C19
unmatched PM (vs EM) 1.0 (0.2 - 6.8)
13 Torii, et al Case-control Case: 19 (M:10/F:9) 28.6±7.85 Variables OR (95%CI)
2001 1981-1998 after bone marrow transplantation Age (10 years increment) 0.47 (0.234 - 0.934)
Japan Control: 81 (M:45/F:36) 34.2±10.4 Chronic GVHD (Yes/No) 5.57 (1.032 - 30.1)
after bone marrow transplantation Pulse regimen (Yes/No) 11.3 (3.15 - 40.44)
14 Lausten, et al Cohort High-dose steroid: 374 (M:206/F:168) 43 (6-66) 11.2% (42/374, average of 26.2 months after transplantation) 1998 1968-1995 Low-dose steroid: 376 (M:239/F:137) 48 (7-76) 5.1% (19/376, average of 20.5 months after transplantation))
Denmark after a kidney transplantation P=0.002
15 Aranow, et al Case-control 66 patients with SLE and steroid treatment 34.9 (18-67) Variables OR (95%CI)
1997 - (M:5/F:61) African-American origin 11.5 (7.3 - 18.0)
US Case: 8 Predonisone (>30mg/day) 4.2 (2.5 - 6.9)
Control: 58 Migraine headache 3.5 (2.2 - 5.4)
Raynaud's phenomenone 1.8 (1.1 - 2.8)
Table 1 continues
Table 1. (continued)
Ref. No. Authors/Year/Country
Study Design/Year/
Follow-up period
Subjects (M:male, F:female) Mean (or median)
age Main result
16 Saisu, et al Case-control Case: 22 (M:17/F:5) 31.0 (SD=8.7) Variables P value
1996 1974-1994 after renal transplantations Intravenous pulse dose of methylprednisolone 0.0009
Japan Control: 47 (M:33/F:14) 29.8 (SD=7.7) Maintenace dose of prednisolone 0.0012
after renal transplantations
After 1982 (after introduce of cyclosporin A) Variables P value
Case: 12 - Intravenous pulse dose of methylprednisolone 0.0013
after renal transplantations Maintenace dose of prednisolone NS
Control: 44 -
after renal transplantations
17 Lausten, et al Cohort Patients with renal transplantations
1988 Case-control Prednisone+Azathioprine: 374 (M:206) - ONFH 42/374
Denmark 1968-1987 CyclosporinA+reduced steroid: 124 (M:69) - ONFH 4/124 (P<0.01)
Variables P value
Case: 46 Patients with rejection (ION+: 22, ION-:35) <0.05
Control: 46
matched for age, sex, number of transplantation, f/u time
