犬の血管肉腫に対する人工化学修飾 microRNA-214 を用いた新規治療法に関する研究
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(357) .
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(359) ʯřĽ he} @<+ ɚˌz}ƴ˱ƄʪȜǣ˕Ƕjĸnz}eůg T C Ō˭ͺW¬®ˈɤƄʪȜǣ˕ǶˠʨīˌrnjȻ}h nŒĉi @<+ !, ȩp}ͺW¬®ˈɤƄʪȜǣ˕ǶŨ ĉŭƴ˱Ũĉƥp}eůg
(360) T ʯřĽ~ !, ʙŰɩɴƳÒ¹ØήƉǽpwTȑĴǧǴŢº®À·¦ Ɛ Ìú ȻƩúh ɐƬú}țĸjdj ȑĴǧȉȘjƯłrwƘƤȈÝ jĺǨ}d
(361) SȢĝć} &+" }ʙŰɩɴƳʎʢĚɯrnʙŰ. ɩɴƳÒ¹ØήǼȌʍĆǸŧpwT!, ˦ǍǓ˨ȩp} &+" }ʎʢƋ øpwċľʧŷ ǺǞĩȝ˳ȝʃ - ŁɅČțh ƚʭ˕Ƕ - ŁɅČțhe}Ŵǧŵ - ŁɅČțhe}ɋǧŵƴ˲Ƿʎʢp}ɯ ʧŷo}e TʯřĽ~ƚʭ˕Ƕ - Čț}ƴ˲jŴǧŵȜŁo} hċľʧŷðȾpwTo ǼȌČțLjŚďʫŤɫĮLjŚðȾp}h nąȇŁlƕơrŒĉzwT&+" ʙŰɩŒȆʍĆ ɚˌȌʙŰɩŒȆǼɀďʫűfnlʍĆĈɳ~dzwT @<+ ʙŰɩɚˌˆĖƟǘʍĆȨǀȡɌœúŗž}űzwT ɚˌň ȩǒňĪȨǀʢĄɃʢɯizwTœúŗž~ǺǞňʃě p}ȩǒňh ɚˌňhe} 0 Ȝć!G Ⱥɋăjɯwj nŘ œħɫƴ˦Ǎʎ˚ĝɏLjŚðȾp}hƴ˱øŃ~dĈɳǷjůgT w ǺǞňʃěp}ȩǒňh ɚˌň~. )- şnjjɯwj (- %.. h ?5 ~śɃʢĄjɯizwniĩǙĖʂɌɏxůgT w.' + ɃʢɯsǯǙĖʂɌɏ~důgTʯřĽ~ºÖÜ ®Æ¥¬ÕÜƝ˄p}ˑew %<CB986G4@<A8 +'<&1 ¡¶ ÜǷ£Ó×~ d ǼȨɩ~ƄʪɩǸʜʅɧéɏȘţƉˑƄʪɨǷƥrnœú ǸʜʅɧéɏŒŶčp}ĩȝǯȝĻɀpɨǷƥrnjʧŷo}e. . .
(362) TʙŰɩɚˌ~ʽƄœħiĻƶow @<+' jˀʷŌˇpĩɩêű růgwĩǙĖ×®¥jŴeůgwjʯřĽ~ʹiĩǙ ĖɯizwTʯřĽÈÚº¨WØ @<+ ʙŰɩɚˌhe} śɃʗƉˑɯsƽʜɮˍǷjdůgwTŹŤǿʷɩȎǬɚˌ Ɯˁɭ %<CB986G4@<A8 +'<&1 @<+ ɚˌˣ{e}oŗ ɟjʉ˒~dT. <A I<GEB ~ʧŷé ǼȨɩ~ () ɼŠˣśɃŽɯi zwTŹĐnŞóďʹƛz}eejC ɅȆr () äĕŌ˭ŗ Ɗ () ǼȨɩɢȭYƚʭȯƯƙĕȊøŃZ{e}oŗɟjʉ ˒~d T ţɍƧƆǧ ?;*
(363) ɃǐɃqwĘá Ƴżēǿ|ǚȳē} ?;*
(364) ǻģɃjȮ ÉĢźqwSęöǪţƧƆïǑǥLj~q|ţɍǧęöıƭjȠȋƯłq ŀŠ¢Ã µÀęÖjļǬrn~ĄÒr~ijgS?;*
(365) ɆŻŽɈűõęÖDŽ}ƫ Þq|h ţɍƧƆĢȴƛűõęÖDŽ ?;*
(366) Ģźrn~jțĸp| e SȢĝć} ?;*
(367) ǚȳƪţɍɃĢźjǯ nű õęÖDŽȓȀĔ ?;*
(368) ɃjĢźqęÖ~ƧƆƪɃƮǐq|qfn~} Ğim ſ ?;*
(369) DZǘjǎÛqwßDzƕjijgSqiqǡÑĥƲȷewűõęÖDŽ~ ţɍƧƆǧ ?;*
(370) ǻģɃǿíĚǝqwțĸƯłts ĹħǡÑĥƲ}ţɍƧƆ ǧ~ęÖDŽuv ?;*
(371) ǻģɃ{e|ÁW£W·Âª§¤½ÃȞǜ ȷew¢ÃµÀDžŮpĚǝjȅȸ}dS . . .
(372) L. ȱ Ǖ~ ?;*
(373) ȑĴǧǚȳěęöǪţȑĴǧǴŢËƄ·¦Ƴq| ¶¯W¤¦ŁȟƫƅȹƔİţɍĪáŖrn~jizwSw ğLJȐńȷ ǯsūȓǮȴƕjdzwS + ŘƥǻŽɈƳr ?;*
(374) ȷewƊă ŕɁȞçǻýǾ~ĘájǤwSĹħɆŻŽɈÚȷwpĚǝj ȅȸ}dS . . .
(375) cQa. Day ０ Cells injection. 20. MRI. 24. 21. 27. miRNA injectiion. 30. 31. MRI. 33. Sacrifice ed. Re21(4.0 106 cells) intraperitoneally. Ƒ
(376) ŝĠėâŖrSƄʪȄƳi ƺĪŤ @<+' ʙŰɩɚˌēƒp ɚ. ˌ ɬhkŎ ĐűzwTʙʖ &+" Ƌø @<+' ɚˌȌɬɚˌƹ˟Ť˖ɬ uvűzw . . .
(377) A. B Tumor. Canine spleen. Mouse spleen. Negative control. CD31. β-actin. . ǰ ţɍƧƆ. ȆȢ~ *,(*. ! ʊʯ ƴ˱ƄʪjƼƬǷdeˎVǴȂœļĬʐĶȠœħˎŮȞŋǸp{{ Ȝǣr œħɫƴɧɄɏLjŚjɯwT +- ) + ƴ˱ȑǤh Ř˳ȝȑǤ~Řɧéɏ h Þ 46G<A ÂÜ»jŗǂo Î ®˳ȝȑǤh ¿¢¸Ç¨ÜºÚWØiŗǂoizwT . . .
(378) Treat. Control B. D. E. C. Post injection. Pre injection. A. Normal. . ǰ &+"Yƚʭ˕Ƕ - ŁɅČțZ -E84G @<+ ɚˌňYɚˌňZ BAGEB? ʅɧéɏɷ˫ @<+' ɚˌňYȩ ǒňZ'BE@4? ŕǞήYǺǞňZƥrT)E8<A=86G<BA @<+' ɚˌȌ)BFG <A=86G<BA @<+' ɚˌƹ˟ŤƥrT ɚˌň @<+' ɚˌȌ ȩǒň @<+' ɚˌȌ ǺǞň ɚˌň @<+' ɚˌƹ˟Ť ȩǒň@<+' ɚˌƹ˟Ť ǺǞňY Z~ɯeŴǧŵŒȆY˂ɡZjɚˌňY ZȩǒňY Z ~ɯwT @<+' ɚˌȌ~ɚˌňYZȩǒňYZ~ŒȆǷõøɣɜĚɯowj @<+' ɚˌƹ˟Ť~ȩǒňY Zʃ}ɚˌňY Z~ŒȆǷõøşnjʼnŪ wT . . .
(379) B. C. D. Control. Treat. A. . . ǰ ďʫLjŚ -E84G @<+ ɚˌňYɚˌňZ BAGEB? ʅɧéɏɷ˫ @<+' ɚˌňYȩ ǒňZƥrT ɚˌňYēʙƢZ ɚˌňYɎǂȝįZ ȩǒňYēʙƢZ ȩǒňYɎǂȝįZ żȟY ZuvňēʙƢƭǪ~dT O@@ ãȂǥá˞Ƿƴ˲Y˂ ɡZjȎšȨ~ɯwTöȟY ZɎǂȝįƭǪ~dTżǚiÿĜʲĩ ȝ˳ȝǯȝh Ǽǣį~dTöȟǑĄħɷȽp}eTì˅ˀƷæĩȝʇȟ ˳ȝƷæh ǼǣįƷæ~ƴ˱ŋǸY˂ñZjȦlɯwTɚˌň~ȩǒň ʃ}ʙŰɩŒȆǴȰkoşnjʼnŪɯwT. . .
(380) B 4 00. ＊. ＊. 1. 4. Weight of foci (g). Number of foci（foci）. A. 300. 200. 100. 1.2 1 0.8 0.6 0. 4 0.2 0. 0. . . 投与群 投与群 対照群 Treat Control l. 投与群 対照群 Treat Control. . ǰ ƴ˱Ǵ ƴ˱ǀˣƥrT -E84G @<+ ɚˌňYɚˌňZ BAGEB? ʅɧéɏɷ˫ @<+' ɚˌňYȩ ǒňZƥrT ¦ÖÆșƴ˱ǴƥrTɚˌň~ʞŇ
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