大門
貴志
（ダイモン
タカシ）
■所属部署
医療統計学
■職名
教授
■学位
博士
(
工学
)
研究分野 生物統計学
主な研究テーマ 医学における統計モデル及び統計的方法論の開発
担当授業 臨床入門，医学統計学・臨床疫学
学術論文 1. Mandai, M., Watanabe, A., Kurimoto, Y., Hirami, Y., Morinaga, C., Daimon, T., Fujihara, M., Akimaru, H., Sakai, N., Shibata, Y., Terada, M., Nomiya, Y., Tanishima, S., Nakamura, M., Kamao, H., Sugita, S., Onishi, A., Ito, T., Fujita, K., Kawamata, S., Go, M., Shinohara, C., Hata, K., Sawada, M., Yamamoto, M., Ohta, S., Ohara, Y., Yoshida, K., Kuwahara, J., Kitano, Y., Amano, N., Umekage, M., Kitaoka, F., Tanaka, A., Okada, C., Takasu, N., Ogawa, S., Yamanaka, S., and Takahashi, M. (2017). Autologous induced stem cell-derived retinal cells for macular degeneration. The New England Journal of Medicine 376(11), 1038-1046.
2. Kainuma, S., Taniguchi, K., Toda, K., Funatsu, T., Kondoh, H., Miyagawa, S., Yoshikawa, Y., Hata, H., Saito, S., Ueno, T., Kuratani, T., Daimon, T., Masai, T., and Sawa, Y. (2017). Predictors and clinical impact of functional mitral stenosis induced by restrictive annuloplasty for ischemic and functional mitral regurgitation. Circulation Journal (in press).
3. Kako, Y., Yamakado, K., Jomoto, W., Nasada, T., Asada, K., Takaki, H. Kobayashi, K., Daimon, T., and Hirota, S. Changes in liver perfusion and function before and after percutaneous occlusion of spontaneous portosystemic shunt. Japanese Journal of Radiology (in press).
4. Demizu, Y., Mizumoto, M., Onoe, T., Nakamura, N., Kikuchi, Y., Shibata, T., Okimoto, T., Hideyuki, S., Akimoto, T., Ono, K., Daimon, T., Murayama, S. (2017). Proton beam therapy for bone sarcomas of the skull base and spine: a retrospective nationwide multicenter study in Japan. Cancer Science (in press).
5. Demizu, Y., Jin, D., Sulaiman, N.S., Nagano, F., Terashima, K., Tokumaru, S., Akagi, T., Fujii, O., Daimon, T., Sasaki, R., Fuwa, N., Okimoto, T. (2017). Particle therapy using protons or carbon ions for unresectable or incompletely resected bone and soft tissue sarcomas of the pelvis. International Journal of Radiation Oncology Biology Physics 98 (2), 367-374.
6. Sagawa, K., Uwa, N., Daimon, T., Sakagami, M., and Tsujimura, T. (2016). Expression of CD44 variant isoforms, CD44v3 and CD44v6, are associated with prognosis in nasopharyngeal carcinoma. The Journal of Laryngology & Otology 130, 843-849.
7. Takano, H., Hiramatsu, M., Kida, H., Uenoyama, M., Horiguchi, K., Yamauchi, T., Kin, K., Shirakawa, Y., Kaneko, M., and Daimon, T. (2016). Severe tricuspid regurgitation after mitral valve surgery: the risk factors and results of the aggressive application of prophylactic tricuspid valve repair. Surgery Today (in press).
8. Tsuji, D., Yokoi, M., Suzuki, K., Daimon, T., Nakao, M., Ayuhara, H., Kogure, Y., Shibata, K., Hayashi, T., Hirai, K., Inoue, K., Hama, T., Takeda, K., Nishio, M., and Itoh, K. (2016). Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study. The Pharmacogenomics Journal (in press).
9. Nakagawa, M., Owada, Y., Izumi, Y., Nonin, S., Sugioka, K., Nakatani, D., Iwata, S., Mizutani, K., Nishimura, S., Ito, A., Fujita, S., Daimon, T., Sawa, Y., Asakura, M., Maeda, M., Fujio, Y., and Yoshiyama, M. (2016). Four cases of investigational therapy with interleukin-11 against acute myocardial infarction. Heart Vessels 31(9), 1574-1578.
10.Takayama, K., Nakamura, T., Takada, A., Makita, C., Suzuki, M., Azami, Y., Kato, T., Hayashi, Y., Ono, T., Toyomasu, Y., Hareyama, M., Kikuchi, Y., Daimon, T., Mitsudo, K., Tohnai, I., and Fuwa, N. (2016). Treatment results of alternating chemoradiotherapy followed by proton beam therapy boost combined with intra-arterial infusion chemotherapy for stage III-IVB tongue cancer. Journal of Cancer Reserch and Clinical Oncology 142(3), 659-667.
11.Wakabayashi, I., and Daimon, T. (2016). Associations between hypo-HDL cholesterolemia and cardiometabolic risk factors in middle-aged men and women: Independence of habitual alcohol drinking, smoking and regular exercise. Obesity Research & Clinical Practice 142, 659-667.
molecular alterations by a randomised controlled trial. British Journal of Cancer 114(1), 21-29. 13.Shirasaka, T., Miyagawa, S., Fukushima, S., Kawaguchi, N., Nakatani, S., Daimon, T., Okita, Y., and
Sawa Y. (2016). Skeletal myoblast cell sheet implantation ameliorates both systolic and diastolic cardiac performance in canine dilated cardiomyopathy Model. Transplantation 100(2), 295-302.
14.Kondoh, H., Satoh, H., Daimon, T., Tauchi, Y., Yamamoto, J., Abe, K., and Matsuda, H. (2016). Outcomes of limited proximal aortic replacement for type A aortic dissection in octogenarians. The Journal of Thoracic and Cardiovascular Surgery 152(2), 439-446.
15. Takada, A., Nakamura, T., Takayama, K., Makita, C., Suzuki, M., Azami, Y., Kato, T., Tsukiyama, I., Hareyama, M., Kikuchi, Y., Daimon, T., Toyomasu, Y., Ii, N., Nomoto, Y., Sakuma, H., and Fuwa, N. (2016). Preliminary treatment results of proton beam therapy with chemoradiotherapy for stage I-III esophageal cancer. Cancer Medicine 5(3), 506-515.
16. Kurosaka, K. Fukunishi, S., Fukui, T., Nishio, S., Fujihara, Y., Okahisa, S., Takeda, Y., Daimon, T., and Yoshiya, S. (2016). Assessment of accuracy and reliability in acetabular cup placement using an iPhone/iPad system. Orthopedics 39(4), e621-626.
17. Nakamura, T, Toda, K, Kuratani, T, Miyagawa, S, Yoshikawa, Y, Fukushima, S, Saito, S, Yoshioka, D, Kashiyama, N, Daimon, T., and Sawa Y. (2015). Diabetes mellitus impairs left ventricular mass regression after surgical or transcatheter aortic valve replacement for severe aortic stenosis. Heart, Lung and Circulation 25(1) 68-74.
18. Guidance Development Review Committee, Working Group for Clinical Studies of Cancer Immunotherapy, Working Group for Effector Cell Therapy, Working Group for CMC/Non-clinical Studies, Working Group for Cancer Vaccines and Adjuvants, Working Group for Anti-immune Checkpoint Therapy and Comprehensive Cancer Immunotherapy, and Biostatistics Subcommittee (2015). 2015 Guidance on cancer immunotherapy development in early-phase clinical studies. Cancer Science 106(12), 1761-1771.
19. Kawamura, M., Miyagawa, S., Fukushima, S., Saito, A., Toda, K., Daimon, T., Shimizu, T., Okano, T., and Sawa, Y. (2015). Xenotransplantation of bone marrow-derived human mesenchymal stem cell sheets attenuates left ventricular remodeling in a porcine ischemic cardiomyopathy model. Tissue Engineering Part A. 21(15-16), 2272-2280.
20. Wakabayashi, I., and Daimon, T. (2015). Alcohol-independent beneficial cardiometabolic profile of individuals with hyper-HDL-cholesterolemia in Japanese men and women. Journal of Clinical Lipidology 9(5), 684-691.
21. Yamakado, M., Nagao, K., Imaizumi, A., Tani, M., Toda, A., Tanaka, T., Jinzu, H., Miyano, H., Yamamoto, H., Daimon, T., Horimoto, K., and Ishizuka, Y. (2015). Plasma free amino acid profiles predict four-year risk of developing diabetes, metabolic syndrome, dyslipidemia, and hypertension in Japanese population. Scientific Reports 5, 11918.
22. Taguchi, A., Sakai, C., Soma, T., Kasahara, Y., Stern, D.M. Kajimoto, K., Ihara, M., Daimon, T., Yamahara, K., Doi, K., Kohara, N., Nishimura, H., Matsuyama, T., Naritomi, H., Sakai, N., and Nagatsuka, K. (2015). Intravenous autologous bone marrow mononuclear cell transplantation for stroke: phase1/2a clinical trial in a homogeneous group of stroke patients. Stem Cells and Development 24(19), 2207-2218.
23. Teramukai, S., Daimon, T., and Zohar, S. (2015). An extension of Bayesian predictive sample size selection design for monitoring efficacy and safety. Statistics in Medicine 34(22), 3029-3039. 24. Kainuma, S., Taniguchi, K., Toda, K., Shudo, Y., Takeda, K., Funatsu, T., Miyagawa, S., Kondoh, H.,
Nishi, H., Yoshikawa, Y., Fukushima, S., Hamada, S., Kudo, K., Daimon, T., and Sawa, Y. (2015). B-type natriuretic peptide response and reverse left ventricular remodeling after surgical correction of functional mitral regurgitation in patients with advanced cardiomyopathy. Journal of Cardiology 66(4), 279-285.
25. Ikegame, K., Yoshida, T., Yoshihara, S., Daimon, T., Shimizu, H., Maeda, Y., Ueda, Y., Kaida, K., Ishii, S., Taniguchi, K., Okada, M., Tamaki, H., Okumura, H., Kaya, H., Kurokawa, T., Kodera, Y., Taniguchi, S., Kanda, Y., and Ogawa, H. (2015). Unmanipulated haploidentical reduced-intensity stem cell transplantation using fludarabine, busulfan, low- dose antithymocyte globulin and steroids for patients in non-complete remission or at high risk of relapse: a prospective multicenter phase I/II study in Japan. Biology of Blood and Marrow Transplantation 21(8), 1495-1505.
26. Fuwa, N., Kodaira, T., Daimon, T., and Yoshizaki, T. (2015). The long-term outcomes of alternating chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: a multiinstitutional phase II study. Cancer Medicine 4(8), 1186-1195.
27. Nakayama, H., Iseki, T., Kanto, R., Daimon, T., Kashiwa, K., and Yoshiya, S. (2015). Analysis of risk factors for poor prognosis in conservatively managed early-stage spontaneous osteonecrosis of the knee. The Knee 23(1), 25-28.
28. Sugishita, S., Imai, T., Matsui, T., Daimon, T., Nozaki, S., Yoshikawa, H., and Oku, Y. (2015). Effects of short term interferential current stimulation on swallowing reflex in dysphagic patients. International Journal of Speech & Language Pathology and Audiology 3(1), 1-8.
evidence for irradiation angiopathy in head and neck cancer. International Journal of Otolaryngology and Head & Neck Surgery 4(2), 108-114.
30. Kainuma, S., Mitsuno, M., Toda, K., Funatsu, T., Nakamura, T., Miyagawa, S., Yoshikawa, Y., Fukushima, S., Yoshioka, D., Saito, T., Nishi, H., Takahashi, T., Sakaki, M., Monta, O., Matsue, H., Masai, T., Sakaguchi, T., Yoshitaka, H., Ueno, T., Kuratani, T., Daimon, T., Taniguchi, K., Miyamoto, Y., Sawa, Y., and Osaka Cardiovascular Surgery Research (OSCAR) Group (2014). Dilated left atrium as a predictor of late outcome after pulmonary vein isolation concomitant with aortic valve replacement and/or coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery 48(5), 765-777. 31. Takagi, M., Demizu, Y., Hashimoto, N., Mima, M., Terashima, K., Fujii, O., Jin, D., Niwa, Y.,
Morimoto, K., Akagi, T., Daimon, T., Sasaki, R., Hishikawa, Y., Abe, M., Murakami, M., and Fuwa, N. (2014). Treatment outcomes of particle radiotherapy using protons or carbon ions as a single-modality therapy for adenoid cystic carcinoma of the head and neck. Radiotherapy and Oncology 113(3), 364-370.
32. Kainuma, S., Kasegawa, H., Miyagawa, S., Nishi, H., Yaku, H., Takanashi, S., Hashimoto, K., Okada, Y., Nakatani, S., Umezu, M., Daimon, T., Sakaguchi, T., Toda, K., Sawa, Y., and Committee of the Japanese Spciety of Stentless Mitral Valve. (2014). In vivo assessment of novel stentless valve in the mitral position. Circulation Journal 79(3), 553-559.
33. Kainuma, S., Miyagawa, S., Fukushima, S., Pearson J., Chen, YC., Saito, A., Harada, A., Shiozaki, M., Iseoka, H., Watabe, T., Watabe, H., Horitsugi, G., Ishibashi, M., Ikeda, H., Tsuchimochi, H., Sonobe, T., Fujii, Y., Naito, H., Umetani, K., Shimizu, T., Okano, T., Kobayashi, E., Daimon, T., Ueno, T., Kuratani, T., Toda, K., Takakura, N., Hatazawa, J., Shirai, M., and Sawa, Y. (2014). Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart. Molecular Therapy 23(2), 374-386.
34. Nishi, H., Toda, K., Miyagawa, S., Yoshikawa, Y., Fukushima, S., Kawamura, M., Saito, T., Yoshioka, D., Daimon, T., and Sawa, Y. (2014). Novel method of evaluating liver stiffness using transient elastography to evaluate perioperative status in severe heart failure. Circulation Journal 79(2), 391-397.
35. Ikeda, M., Tsuji, D., Yamamoto, K., Kim, YI., Daimon, T., Iwabe, Y., Hatori, M., Makuta, R., Hayashi, H., Inoue, K., Nakamichi, H., Shiokawa, M., and Itoh, K. (2014). Relationship between ABCB1 gene polymorphisms and severe neutropenia in patients with breast cancer treated with doxorubicin/cyclophosphamide chemotherapy. Drug Metabolism and Pharmacokinetics 30(2), 149-153. 36. Fujii, O., Demizu, Y., Hashimoto, N., Takagi, M., Terashima, K., Mima M., JIn, D., Nagano, F.,
Katsui, K., Okimoto, T., Iwata, H., Niwa, Y., Yamashita, T., Akagi, T., Daimon, T., Sasaki, R., Hishikawa, Y., Abe, M., Murakami, M., and Fuwa, N. (2014). Particle therapy for clinically diagnosed stage I lung cancer: comparison with pathologically proven non-small cell lung cancer. Acta Oncologica 54(3), 315-321.
37. Saito, S., Toda, K., Miyagawa, S., Yoshikawa, Y., Fukushima, S., Sakata, Y., Mizote, I., Daimon, T., and Sawa, Y. (2014). Hemodynamic changes during left ventricular assist device-off test correlate with the degree of cardiac fibrosis and predict the outcome after device explantation. Journal of Artificial Organs 18(1), 27-34.
38. Sulaiman, NS., Fujii, O., Demizu, Y., Terashima, K., Niwa, Y., Akagi, T., Daimon, T., Murakami, M., Sasaki, R., and Fuwa, N. (2014). Particle beam radiation therapy using carbon ions and protons for oligometastatic lung tumors. Radiation Oncology 9, 183.
39. Maruo, K., Moriyama, T., Tachibana, T., Inoue, S., Arizumi, F., Daimon, T., and Yoshiya, S. (2014). The impact of dynamic factors on surgical outcomes after double-door laminoplasty for ossification of the posterior longitudinal ligament of the cervical spine. Journal of Neurosurgery: Spine 21(6), 938-943. 40. Torii, I., Shimizu, S., Daimon, T., Shinohara, Y., Kudo, T., Sato, A., and Tsujimura, T. (2014).
Exposure to high doses of lipopolysaccharide during ovalbumin sensitization prevents the development of allergic Th2 responses to a dietary antigen. Journal of Toxicologic Pathology 27(3-4), 205-215 (Erratum in: Journal of Toxicologic Pathology. 2016 Jan;29(1):74).
41. Makita, C., Nakamura, T., Takada, A., Takayama, K., Suzuki, M., Azami, Y., Kato, T., Tsukiyama, I., Hareyama, M., Kikuchi, Y., Daimon, T., Hata, M., Inoue, T., and Fuwa, N. (2014). High-dose proton beam therapy for stage I non-small cell lung cancer: clinical outcomes and prognostic factors. Acta Oncologica 54(3), 307-314.
42. Watanabe, Y., Miyagawa, S., Fukushima, S., Daimon, T., Shirakawa, Y., Kuratani, T., and Sawa, Y. (2014). Development of a prostacyclin-agonist-eluting aortic stent graft enhancing biological
attachment to the aortic wall. The Journal of Thoracic and Cardiovascular Surgery 148(5), 2325-2334. 43. Kamata, S., Miyagawa, S., Fukushima, S., Nakatani, S., Kawamoto, A., Saito, A., Harada, A., Shimizu,
T., Daimon, T., Okano, T., Asahara, T., and Sawa, Y. (2014). Improvement of cardiac stem cell-sheet therapy for chronic ischemic injury by adding endothelial progenitor cell transplantation: analysis of layer-specific regional cardiac function. Cell Transplantation 23(10), 1305-1319.
The British Journal of Radiology 87(1033).
45. Tsuzuki, K., Hinohira, Y., Takebayashi, H., Kojima, Y., Yukitatsu, Y., Daimon, T., and Sakagami, M. (2014). Novel endoscopic scoring system after sinus surgery. Auris Nasus Larynx 41(5), 450-454. 46. Wakabayashi, I., and Daimon, T. (2014). The ``cardiometabolic index" as a new marker determined by
adiposity and blood lipids for discrimination of diabetes mellitus. Clinica Chimica Acta 438, 274-278. 47. Tsuji, D., Kamezato, M., Daimon, T., Taku, K., Hatori, M., Ikeda, M., Hayashi, H., Inoue, K., Eto,
T., and Itoh, K. (2014). Retrospective analysis of severe neutropenia in patients receiving concomitant administration of docetaxel and clarithromycin. Chemotherapy 59(6), 407-413.
48. Kinugawa, K., Nagai, R., Inoue, H., Atarashi, H., Seino, Y., Yamashita, T., Shimizu, W., Aiba, T., Kitakaze, M., Sakamoto, A., Ikeda, T., Imai, Y., Daimon, T., Fujino, K., Nagano, T., Okamura, T., Hori, M., and J-Land Investigators. (2014). Impacts of patient characteristics on the effectiveness of landiolol in AF/AFL patients complicated with LV dysfunction: Subgroup analysis of the J-Land study. Advances in Therapy 31(4): 426-439 (Erratum in Advances in Therapy. 2014 May; 31(5):577-8.). 49. Demizu, Y., Fujii, O., Terashima, K., Mima, M., Hashimoto, N., Niwa, Y., Akagi, T, Daimon, T.,
Murakami, M., and Fuwa, N. (2014). Particle therapy for mucosal melanoma of the head and neck. A single-institution retrospective comparison of proton and carbon ion therapy. Strahlentherapie und Onkologie 190(2), 186-191.
50. Watanabe, Y., Shimamura, K., Yoshida, T., Daimon, T., Shirakawa, Y., Torikai, K., Sakamoto, T., Shijo, T., Toda, K., Kuratani, T., and Sawa, Y. (2014). Aortic remodeling as a prognostic factor for late aortic events after thoracic endovascular aortic repair in type B aortic dissection with patent false lumen. Journal of Endovascular Therapy 21(4), 517-525.
51. Nakamura, T., Daimon, T., Mouri, N., Masuda, H., and Sawa, Y. (2014). Staphylococcus aureus and repeat bacteremia in febrile patients as early signs of sternal wound infection after cardiac surgery. Journal of Cardiothoracic Surgery 9, 80.
52. Kainuma, S., Taniguchi, K., Toda, K., Funatsu, T., Miyagawa, S., Kondoh, H., Masai, T., Otake, S., Yoshikawa, Y., Nishi, H., Sakaguchi, T., Ueno, T., Kuratani, T., Daimon, T., and Sawa, Y. (2014). Restrictive mitral annuloplasty with or without surgical ventricular reconstruction in ischaemic cardiomyopathy: impacts on neurohormonal activation, reverse left ventricular remodelling and survival. European Journal of Heart Failure 16(2), 189-200.
53. Wakabayashi, I., and Daimon, T. (2014). A strong association between lipid accumulation product and diabetes mellitus in japanese women and men. Journal of Atherosclerosis and Thrombosis 21(3), 282-288.
54. Kubota, Y., Miyagawa, S., Fukushima, S., Saito, A., Watabe, H., Daimon, T., Sakai, Y., Akita, T., and Sawa, Y. (2014). Impact of cardiac support device combined with slow-release prostacyclin agonist in a canine ischemic cardiomyopathy model. The Journal of Thoracic and Cardiovascular Surgery 147(3), 1081-1087.
55. Katsura, H., Mishiro, Y., Adachi, O., Ogino, K., Daimon, T., and Sakagami, M. (2014). Long-term deterioration of bone-conduction hearing level in patients with labyrinthine fistula. Auris Nasus Larynx 41(1), 6-9.
56. Daimon, T. and Zohar, S. (2013). An adaptive model switching approach for phase I dose-finding trials. Pharmaceutical Statistics 12(4), 225-232.
57. Nagai, R., Kinugawa, K., Inoue, H., Atarashi, H., Seino, Y., Yamashita, T., Shimizu, W., Aiba, T., Kitakaze, M., Sakamoto, A., Ikeda, T., Imai, Y., Daimon, T., Fujino, K., Nagano, T., Okamura, T., Hori, M., and the J-Land Investigators (2013). Urgent management of rapid heart rate in patients with atrial fibrillation/flutter and left ventricular dysfunction: comparison of the ultra-short-acting β1-selective blocker landiolol with digoxin (J-Land Study). Circulation Journal 77(4), 908-916. 58. Kawamura, M., Miyagawa, S., Fukushima, S., Saito, A., Miki, K., Ito, E., Sougawa, N., Kawamura,
T., Daimon, T., Shimizu, T., Okano, T., Toda, K., and Sawa, Y. (2013). Enhanced survival of transplanted human induced pluripotent stem cell-derived cardiomyocytes by the combination of cell sheets with the pedicled omental flap technique in a porcine heart. Circulation 128, S87-94. 59. Fujii, O., Demizu, Y., Hashimoto, N., Araya, M., Takagi, M., Terashima, K., Mima, M., Iwata, H.,
Niwa, Y., Jin, D., Daimon, T., Sasaki, R., Hishikawa, Y., Abe, M., Murakami, M., and Fuwa, N. (2013). A retrospective comparison of proton therapy and carbon ion therapy for stage I non-small cell lung cancer. Radiotherapy and Oncology 109(1), 32-37.
60. Maeda, K., Kuratani, T., Torikai, K., Shimamura, K., Mizote, I., Ichibori, Y., Takeda, Y., Daimon, T., Nakatani, S., Nanto, S., and Sawa, Y. (2013). Impact of electrocardiogram-gated multi-slice computed tomography-based aortic annular measurement in the evaluation of paravalvular leakage following transcatheter aortic valve replacement: the efficacy of the OverSized AortiC Annular ratio (OSACA ratio) in TAVR. Journal of Cardiac Surgery 28(4), 373-379.
62. Shimokawa, M., Hasegawa, S., Fukuoka, K., Okada, M., Yokoi, K., Tanaka, F., Yamanaka, T., Daimon, T., and Nakano, T. (2013). A feasibility study of induction pemetrexed plus cisplatin followed by pleurectomy/decortication aimed at macroscopic complete resection for malignant pleural mesothelioma. Japanese Journal of Clinical Oncology 43(5), 575-578.
63. Kainuma ,S., Funatsu, T., Kondoh H., Mitsuno M., Daimon, T., Toda K., Sawa Y., and Taniguchi, K. (2013). Novel surgical ablation through a septal-superior approach for valvular atrial fibrillation: 7-year single-centre experience. European Journal of Cardio-Thoracic Surgery 44(6), 1013-1022.
64. Shingyoji, M., Iizasa, T., Higashiyama, M., Imamura, F., Saruki, N., Imaizumi, A., Yamamoto, H., Daimon, T., Tochikubo, O., Mitsushima, T., Yamakado, M., and Kimura, H. (2013). The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer. BMC Cancer 13, 77.
65. Tsuji, D., Kim, YI., Nakamichi, H., Daimon, T., Suwa, K., Iwabe, Y., Hayashi, H., Inoue, K., Yoshida, M., and Itoh, K. (2013). Association of ABCB1 polymorphisms with the antiemetic efficacy of granisetron plus dexamethasone in breast cancer patients. Drug Metabolism and Pharmacokinetics 28(4), 299-304.
66. Oka, H., Tsuzuki, K., Takebayashi, H., Kojima, Y., Daimon, T., and Sakagami, M. (2013). Olfactory changes after endoscopic sinus surgery in patients with chronic rhinosinusitis. Auris Nasus Larynx 40(5), 452-457.
67. Kurohane, K., Sahara, Y., Kimura, A., Narukawa, M., Watanabe, T., Daimon, T., and Imai, Y. (2013). Lack of transient receptor potential melastatin 8 activation by phthalate esters that enhance contact hypersensitivity in mice. Toxicology Letters 217(3), 192-196.
68. Akahori, H., Tsujino, T., Naito, Y., Yoshida, C., Lee-Kawabata, M., Ohyanagi, M., Mitsuno, M., Miyamoto, Y., Daimon, T., and Masuyama, T. (2013). Intraleaflet haemorrhage as a mechanism of rapid progression of stenosis in bicuspid aortic valve. International Journal of Cardiology 167(2), 514-518. 69. Tomita, T., Okugawa, T., Yamasaki, T., Kondo, T., Toyoshima, F., Sakurai, J., Oshima, T., Fukui,
H., Daimon, T., Watari, J., Kashiwagi, T., Matsumoto, T., and Miwa, H. (2013). Use of scintigraphy to evaluate gastric accommodation and emptying: comparison with barostat. Journal of Gastroenterology and Hepatology 28(1), 106-111.
70. Okura, H., Saga, A., Soeda, M., Miyagawa, S., Sawa, Y., Daimon, T., Ichinose, A., and Matsuyama, A. (2012). Intracoronary artery transplantation of cardiomyoblast-like cells from human adipose tissue-derived multi-lineage progenitor cells improve left ventricular dysfunction and survival in a swine model of chronic myocardial infarction. Biochemical and Biophysical Research Communications 425(4), 859-865.
71. Watari, J., Tomita, T., Toyoshima, F., Sakurai, J., Kondo, T., Asano, H., Yamasaki, T., Okugawa, T., Tanaka, J., Daimon, T., Oshima, T., Fukui, H., Hori, K., Matsumoto, T., and Miwa, H. (2012). The incidence of "silent" free air and aspiration pneumonia detected by CT after gastric endoscopic submucosal dissection. Gastrointestinal Endoscopy 76(6), 1116-1123.
72. Kin, K., Miyagawa, S., Fukushima, S., Shirakawa Y., Torikai, K., Shimamura, K., Daimon, T., Kawahara Y., Kuratani, T., and Sawa, Y. (2012). Tissue- and plasma-specific microRNA signatures for atherosclerotic abdominal aortic aneurysm. Journal of the American Heart Association 1(5), e000745. 73. Nozaki, S., Matsui, T., Umaki, Y., Yoshikawa, H., Kaneto, T., Sugishita, S., Imai, T., Fukuoka, T.,
Oguro, D., Inokawa, M., Domen, K., and Daimon, T. (2012). Rhythm therapy with a metronome to treat dysphagia in patients with Parkinson's disease. Deglutition (Enge Igaku) 1(2), 400-412.
74. Teramukai, S., Daimon, T., and Zohar, S. (2012). A Bayesian predictive sample size selection design for single-arm exploratory clinical trials. Statistics in Medicine 31(30), 4243-4254.
75. Masuyama, T., Tsujino, T., Origasa, H., Yamamoto, K., Akasaka, T., Hirano, Y., Ohte, N., Daimon, T., Nakatani, S., and Ito, H. (2012). Superiority of long-acting to short-acting loop diuretics in the treatment of congestive heart failure. Circulation Journal 76(4), 833-842.
76. Sakaguchi, A., Katsura, H., Nin, T., Adachi, O., Mishiro, Y., Daimon, T., and Sakagami, M. (2012). Preoperative assessment of taste function in patients with middle ear disease. Otology & Neurotology 33(5), 761-764.
77. Kawamura, M., Miyagawa, S., Miki, K., Saito, A., Fukushima, S., Higuchi, T., Kawamura, T., Kuratani, T., Daimon, T., Shimizu, T., Okano, T., and Sawa, Y. (2012). Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model. Circulation 126, S29-37.
78. Kainuma, S., Taniguchi, K., Daimon, T., Sakaguchi, T., Funatsu, T., Miyagawa, S., Kondoh, H., Takeda, K., Shudo, Y., Masai, T., Ohishi, M., and Sawa, Y. (2012). Mitral valve repair for medically refractory functional mitral regurgitation in patients with end-stage renal disease and advanced heart failure. Circulation 126, S205-213.
79. Saito, S., Sakaguchi, T., Miyagawa, S., Nishi, H., Yoshikawa, Y., Fukushima, S., Daimon, T., and Sawa, Y. (2012). Recovery of right heart function with temporary right ventricular assist using a centrifugal pump in patients with severe biventricular failure. The Journal of Heart and Lung Transplantation 31(8), 858-864.
T., Daimon, T., Ueno, T., Kuratani, T., and Sawa, Y. (2012). Predictor of early mortality for severe heart failure patients with left ventricular assist device implantation: significance of INTERMACS level and renal function. Circulation Journal 76(7), 1631-1638.
81. Okishio, K., Mio, T., Kawahara, M., Yoshioka H., Yanagihara, K., Daimon, T., and Furuse, K. (2012). A weekly combination of carboplatin and irinotecan for previously untreated extensive disease small-cell lung cancer, results of a minimum follow-up of 3 years: a multi-center Phase II trial JMTO LC02-02. Japanese Journal of Clinical Oncology 42(5), 387-393.
82. Kawahara, M., Kubo, A., Komuta, K., Fujita, Y., Sasaki, Y., Fukushima, M., Daimon, T., Furuse, K., Mishima, M., and Mio, T. (2012). A phase I study of amrubicin and fixed dose of irinotecan (CPT-11) in relapsed small cell lung cancer: Japan Multinational Trial Organization LC0303. Journal of Thoracic Oncology 7(12), 1845-1849.
83. Wakabayashi, I., and Daimon, T. (2012). Age-dependent decline of association between obesity and hyperglycemia in men and women. Diabetes Care 35(1), 175-177.
84. Wakabayashi, I., and Daimon, T. (2012). Receiver-operated characteristics (ROCs) of the relationships between obesity indices and multiple risk factors (MRFs) for atherosclerosis at different ages in men and women. Archives of Gerontology and Geriatrics 55(1), 96-100.
85. Tsuji, D., Kim, YI., Taku, K., Nakagaki, S., Ikematsu, Y., Tsubota, H., Maeda, M., Hashimoto, N., Kimura, M., and Daimon, T. (2012). Comparative trial of two intravenous doses of granisetron (1 versus 3 mg) in the prevention of chemotherapy-induced acute emesis: a double-blind, randomized, non-inferiority trial. Supportive Care in Cancer 20(5), 1057-1064.
86.Saga, A., Okura, H., Soeda, M., Tani, J., Fumimoto, Y., Komoda, H., Moriyama, M., Moriyama, H., Yamashita, S., Ichinose, A., Daimon, T., Hayakawa T., and Matsuyama, A. (2011). HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits. Biochemical and Biophysical Research Communications 412(1), 50-54.
87.Kainuma, S., Taniguchi, K., Daimon, T., Sakaguchi, T., Funatsu, T., Kondoh, H., Miyagawa, S., Takeda, K., Shudo, Y., Masai, T., Fujita, S., Nishino, M., Sawa, Y., and Osaka Cardiovascular Surgery Research (OSCAR) Group. (2011). Does stringent restrictive annuloplasty for functional mitral regurgitation cause functional mitral stenosis and pulmonary hypertension? Circulation 124, S97-106. 88.Imanishi, Y., Miyagawa, S., Maeda, N., Fukushima, S., Kitagawa-Sakaida, S., Daimon, T., Hirata, A.,
Shimizu, T., Okano, T., Shimomura, I., and Sawa, Y. (2011). Induced adipocyte cell-sheet ameliorates cardiac dysfunction in a mouse myocardial infarction model: a novel drug delivery system for heart failure. Circulation 124, S10-17.
89.Kainuma, S., Taniguchi, K., Toda, K., Funatsu, T., Kondoh, H., Nishino, M., Daimon, T., and Sawa, Y. (2011). Pulmonary hypertension predicts adverse cardiac events after restrictive mitral annuloplasty for severe functional mitral regurgitation. The Journal of Thoracic and Cardiovascular Surgery 142(4), 783-792.
90.Daimon, T., Zohar, S., and O'Quigley, J. (2011). Posterior maximization and averaging for Bayesian working model choice in the continual reassessment method. Statistics in Medicine 30(13), 1563-1573. 91.Akahori, H., Tsujino, T., Naito, Y., Matsumoto, M., Lee-Kawabata, M., Ohyanagi, M., Mitsuno, M.,
Miyamoto, Y., Daimon, T., Hao, H., Hirota, S., and Masuyama, T. (2011). Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis. European Heart Journal 32(7), 888-896.
92.Wakabayashi, K., Tsujino, T., Naito, Y., Ezumi, A., Lee-Kawabata, M., Nakao, S., Goda, A., Sakata, Y., Yamamoto, K., Daimon, T., and Masuyama, T. (2011). Administration of angiotensin-converting enzyme inhibitors is associated with slow progression of mild aortic stenosis in Japanese patients. Heart and Vessels 26(3), 252-257.
93.Takebayashi, H., Tsuzuki, K., Oka, H., Fukazawa, K., Daimon, T., and Sakagami, M. (2011). Clinical availability of a self-administered odor questionnaire for patients with olfactory disorders. Auris Nasus Larynx 38(1), 65-72.
94.Uwa, N., Kataoka TR., Torii, I., Sato, A., Nishigami, T., Song, M., Daimon, T., Saeki, N., Sagawa, K., Mouri, T., Terada, T., Sakagami, M., and Tsujimura, T. (2011). CD44 expression is related to poor prognosis of hypopharyngeal squamous cell carcinoma. Acta Oto-Laryngologica 131(3), 323-329.
95.清野仁美・湖海正尋・大門貴志 ・松永寿人 (2015). 多職種連携による精神障害患者の周産期管理.
総合病院精神医学 27(3) 198-204.
96.羽鳥正浩・辻大樹・多久佳成・大門貴志 ・亀里真耶・池田翠・幕田龍・林秀樹・井上和幸・伊藤邦彦
(2014). ゲムシタビン施行切除不能膵癌患者に於ける予後因子の検討. 医療薬学 40, 734-741.
97.上田順二・友金祐介・泉本修一・森鑑二・三刀屋由華・道免和久・大門貴志 ・有田憲生 (2013). 頭頂
葉腫瘍症例におけるGerstmann症候の検討. 兵庫医科大学医学会雑誌 38, 89-96.
98.大門貴志 (2013). がん臨床試験のデザインと解析のためのBayes流統計学. 兵庫医科大学医学会雑
誌 38, 67-76.
99.大門貴志 (2012). 連続再評価法とその周辺 (II) －連続再評価法の修正・拡張版と関連デザイン－.
計量生物学 33, 31-76.
1-29.
著書 1. Daimon, T., Hirakawa, A., and Matsui, S. Phase I Dose-finding Designs and Their Applicability to Targeted Therapies. pp.53-70. In “Design and Analysis of Clinical Trials for Predictive Medicine”, (Ed. S. Matsui, M. Buyse, R. Simon), Chapman and Hall/CRC Press. 2015.
2. 大門貴志 訳 (2016). Box-Cox変換. 統計科学百科事典. 丸善出版株式会社, 東京.
3. 手良向聡訳・大門貴志 訳 (2014).『臨床試験デザイン：ベイズ流・頻度流適応的デザイン [英語標題：
Yin, G. (2012). Clinical Trial Design: Bayesian and Frequentist Adaptive Methods. John Wiley & Sons]』, (株) メディカル・パブリケーションズ, 東京, 2014.
主な学会発表 1. Teramukai, S., Daimon, T., and Zohar, S. (2013). A new design for phase II single-arm clinical trials: Bayesian predictive sample size selection design. 2013 Amcerican Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, USA, May 31-June 4.
2. Teramukai, S., Daimon, T., and Zohar, S. (2012). A Bayesian predictive sample size selection design for single-arm exploratory clinical trials. International Society for Bayesian Analysis 2012 World Meeting, Kyoto, Japan, June 25-29.
3. 柿爪智行・張方紅・大門貴志 ・川崎洋平 (2016). 2値変数における有効/無効を同時に考慮したベイズ
流症例数設計法の提案. 2016年度統計関連学会連合大会, 金沢, 講演報告集, 19, 2016年9月5 日.
4. 中尾將彦・辻大樹・鈴木賢一・横井茉里・大門貴志 ・鮎原秀明・小暮友毅・柴田和彦・林稔展・武田晃
司・西尾誠人・濱敏弘・伊藤邦彦 (2015). CDDP誘発性悪心・嘔吐患者におけるABCB1および
ABCG2遺伝子多型の制吐効果に与える影響(TRIPLE studyにおけるゲノム薬理学研究). 日本癌治
療学会第53回学術集会, 京都, 講演要旨集, 2015年10月31日.
5. 大門貴志 (2015). 臨床研究における統計家の在り方. 日本計算機統計学会第29回シンポジウム, 釧
路，講演要旨集, 63-66, 2015年11月27日.
6. 大門貴志 (2013). 用量探索試験における連続再評価法とその周辺 (日本計量生物学会奨励賞受賞
者講演). 2013年度統計関連学会連合大会, 豊中, 講演要旨集, 113, 2013年9月10日.
7. 大門貴志 (2013). 企画セッション：日本計量生物学会シンポジウム：医学分野における統計教育のあり
方 (医学部におけるモデル・コア・カリキュラムと統計関連講義内容の一例). 2013年度統計関連学会
連合大会, 豊中, 講演要旨集, 70, 2013年9月10日.
8. 手良向聡・大門貴志. (2012). 期待奏効確率の不確実性を考慮した第II相単群ベイズ流適応型デザ
イン. 第50回日本癌治療学会学術集会，講演要旨集，横浜，2012年10月26日.
9. 辻大樹・大門貴志 ・岩部悠太郎・多久佳成・渡辺昌也・内田恭之・青島広明・安井博史・伊藤邦彦・朴
成和・山本信之・金容壱 (2012). 化学療法誘発性悪心・嘔吐発現におけるリスク因子の解析. 第50回
日本癌治療学会学術集会，講演要旨集，横浜，2012年10月26日.
10.多久佳成・辻大樹・大門貴志 ・渡辺昌也・内田恭之・青島広明・安井博史・伊藤邦彦・山本信之・朴成
和・金容壱. (2012). 本邦における大腸癌 初回mFOLFOX6療法に対するグラニセトロン(Gra)および
デキサメタゾン (Dex) の予防的制吐効果の検討. 日本臨床腫瘍学会第10回学術集会, 大阪, 講演
要旨集, 2012年7月26-28日.
特許 なし
受賞歴 兵庫医科大学 学生が選ぶベストティーチャー賞, 2015年
日本計量生物学会 奨励賞, 2013年
兵庫医科大学 学生が選ぶベストティーチャー賞, 2011年
日本計算機統計学会 奨励賞, 2005年
The 10th Japan-Korea Joint Conference of Statistics, Wakimoto Memorial Prize, 2000年
主な所属学会等 2001年～
2002年～
2003年～
2004年～
2008年～
2014年～
International Association for Statistical Computing 日本計算機統計学会
International Biometrics Society 日本計量生物学会
応用統計学会
American Statistical Association International Statistical Institute 日本臨床薬理学会
International Society for Clinical Biostatistics会員 日本行動計量学会会員
研究資金獲得状況 2015～2017年
2012～2014年
外部
外部
科研費・基盤研究(C)「抗がん剤の最適投与スケジュールの探索
と決定のための統計的なデザインと推測法の開発」(研究代表
者) 3,770千円 (予定)
科研費・若手研究(B)「抗がん剤の用量探索研究のデザイン及び
髙岡
一樹
（タカオカ
カズキ）
■所属部署
歯科口腔外科
■職名
講師
■学位
医学博士
研究分野 口腔外科
主な研究テーマ 骨微小環境における破骨細胞前駆細胞の分化 骨吸収抑制薬関連顎骨壊死発症リスクに関する研究
担当授業 歯・顎・口腔系の疾患
学術論文 1. Zushi Y, Takaoka K, Tamaoka J, Ueta M, Noguchi K, Kishimoto K. Treatment with teriparatide for advanced bisphosphonate-related osteonecrosis of the jaw around dental implants: a case report. Int J Implant Dent. 2017 Dec;3(1):11.
2. Fung P, Bedogni G, Bedogni A, Petrie A, Porter S, Campisi G, Bagan J, Fusco V, Saia G, Acham S, Musto P, Petrucci MT, Diz P, Colella G, Mignogna MD, Pentenero M, Arduino P, Lodi G, Maiorana C, Manfredi M, Hallberg P, Wadelius M, Takaoka K, Leung YY, Bonacina R, Schiødt M, Lakatos P, Taylor T, De Riu G, Favini G, Rogers SN, Pirmohamed M, Nicoletti P; GENVABO Consortium, Fedele S. Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study. Oral Dis. 2017;23(4):477-483
3. Takaoka K, Segawa E, Yamamura M, Zushi Y, Urade M, Kishimoto H. Dental implant treatment in a young woman after marginal mandibulectomy for treatment of mandibular gingival carcinoma: a case report. Int J Implant Dent. 2015 Dec;1(1):20.
4. Takaoka K, Yamamura M, Nishioka T, Abe T, Tamaoka J, Segawa E, Shinohara M, Ueda H, Kishimoto H, Urade M. Establishment of an Animal Model of Bisphosphonate-Related Osteonecrosis of the Jaws in Spontaneously Diabetic Torii Rats. PLoS One. 2015 Dec 14;10(12):e0144355. doi:
10.1371/journal.pone.0144355.
5. Zushi Y, Noguchi K, Moridera K, Takaoka K, Kishimoto H. Osteonecrosis of the jaw in an AIDS patient: a case report. AIDS Res Ther. 2015 Apr 30;12:13. doi: 10.1186/s12981-015-0049-8.
6. Yoshikawa K, Noguchi K, Nakano Y, Yamamura M, Takaoka K, Hashimoto-Tamaoki T, Kishimoto H. Int J Oncol. The Hippo pathway transcriptional co-activator, YAP, confers resistance to cisplatin in human oral squamous cell carcinoma. 2015;46(6):2364-70.
7. Takaoka K, Hidaka S, Hashitani S, Segawa E, Yamamura M, Tanaka N, Zushi Y, Noguchi K, Kishimoto H, Urade M. Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor.Int J Oncol. 2013;43(3):737-45.
8. Takaoka K, Segawa E, Noguchi K, Kishimoto H, Urade M. Maxillary subperiosteal implantitis that caused severe bone resorption of the maxilla with perforation of the maxillary sinus and sinusitis: A case report. Open Journal of Stomatology, 2013;3:226-9.
9. Yamamura M, Noguchi K, Nakano Y, Segawa E, Zushi Y, Takaoka K, Kishimoto H, Hashimoto-Tamaoki T, Urade M. Functional analysis of Zyxin in cell migration and invasive potential of oral squamous cell carcinoma cells. Int J Oncol. 2013;42(3):873-80.
10.Noguchi K, Kishimoto H, Yamanegi K, Moridera K, Takaoka K, Urade M. Unicystic ameloblastoma metastasizing to multiple cervical lymph nodes. J Surg Case Rep. 2013 May 9;2013(5). pii: rjt033. doi: 10.1093/jscr/rjt033.
11.Urade M, Noguchi K, Takaoka K, Moridera K, Kishimoto H. Up-regulation of neutrophil
gelatinase-associated lipocalin in oral squamous cell carcinoma: relation to cell differentiation. Oncol Rep. 2011;26(6):1415-21.
12.高岡一樹．再建プレートおよび遊離皮弁による下顎再建後にインプラント・オーバーデンチャーによる治 療を行った１症例.日本口腔インプラント学会誌，(in press).
13.岸本裕充，長谷川陽子，高岡一樹，野口一馬．【「口から食べる」を支援する栄養管理】 食べられる口 を CREATE するためのオーラルマネジメント．日本静脈経腸栄養学会雑誌，31(2)，687-92，2016．
14.吉川恭平，野口一馬，山村倫世，高岡一樹，森寺邦康，岸本裕充．上下顎犬歯・小臼歯部に左右対
称性に 8 歯の埋伏過剰歯が出現した 1 例．日本口腔外科学会雑誌，60(6)，394-8，2014.
15.野口一馬，寺田友紀，中野芳朗，山村倫世，吉川恭平，頭司雄介，森寺邦康，高岡一樹，浦出雅裕，
岸本裕充．口腔扁平上皮癌の発生における Human papillomavirus(HPV)感染の関与と診断法の検討． 日本口腔感染症学会，20(2)，70-6，2013．
16.高岡一樹，瀬川英美，頭司雄介，山村倫世，本田公亮，岸本裕充，浦出雅裕. 頭蓋骨弁による下顎再
9-14，2013.
17.名取 淳、中野喜博、木下勝巳、塚本康裕、高岡一樹、口腔内大量出血を契機に診断されたビスフォ
スフォネート関連顎骨壊死の１例．大阪府歯科医師会雑誌，718，54-55，2012.
18.奥井 森、野口一馬、森寺邦康、高岡一樹、岸本裕充、浦出雅裕、超選択的動注化学療法が有効であ
った上顎歯肉小細胞癌の 1 例．日本口腔外科学会雑誌，58(4)，247-51，2012.
19.森寺邦康、野口一馬、冨士原将之、山本 聡、高岡一樹、奥井 森、浦出雅裕、頭頸部扁平上皮癌に
おける超選択的動注化学療法併用放射線療法の治療成績．日本口腔腫瘍学会，23(4)，129-38， 2011.
著書 1. 本音を教えて! GP が知りたいインプラント外科 Q＆A67（共著）2015
2. 65 歳以上の患者へのインプラント治療・管理ガイドー要介護になっても対応できるために（共著）2014 3. 口腔インプラント学 学術用語集（共著）2014
4. 歯界展望別冊/Q＆A 歯科のくすりがわかる本（共著）2014
主な学会発表 1. Tmaoka J., Takaoka K., Ueta M., Araki H., Nishida M., Noguchi K., Kishimoto H., The effect of TGF-β1 on osteoclast precursors in the bone microenvironment. 23rd Congress of the European Association for Cranio-Maxillo-Facial Surgery, London, UK, 2016.
2. Tmaoka J., Takaoka K., Nishida M., Araki H., Noguchi K., Kishimoto H., Effect of TGF-β1 on osteoclast precursors in the bone microenvironment. IADR ANZ Division 55th Annual Scientific Meeting, Dunedin, New Zealand, 2015.
3. Takaoka K., Yamamura M,, Nishioka T., Abe T., Segawa E., Noguchi K., Urade M., Kishimoto H., Bisphosphonates-related osteonecrosis of the jaws using Spontaneously Diabetic Torii rats. The 2014 Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, Hawaii, USA, 2014.
4. Takaoka K., Nishioka T., Abe T., Yamamura M., Segawa E., Zushi Y., Noguchi K., Urade M., Kishimoto H., Bisphosphonates-related osteonecrosis of the jaws using Spontaneously Diabetic Torii rats. The 2nd Meeting of the International Association of Dental Research-Asia Pacific Region, Bangkok, Thailand, 2013.
5. Takaoka K., Nishioka N., Abe T., Yamamura M., Ohtsu N., Segawa E., Zushi Y., Okui S., Noguchi K., Kishimoto H., Urade M., Bisphosphonates-related osteonecrosis of the jaws using spontaneous diabetic Torii rats. 21st Congress of the European Association for Cranio-Maxillo-Facial Surgery, Dubrovnik, Croatia, 2012.
6. Takaoka K., Hidaka S., Hashitani S., Yamamura M., Segawa E., Zushi Y., Noguchi K., Kishimoto H., Urade M., Effect of NOS inhibitors and CXCR4 antagonist on tumor growth and metastasis of human adenoid cyctic carcinoma xenografted into nudemice. 20th International Conference of Oral and Maxillofacial Surgery, Santiago, Chile, 2011.
7. 髙岡一樹．シンポジウム MRONJ とどう向き合うか．インプラント専門医，整形外科医，内科医の立場か ら．薬剤関連顎骨壊死(MRONJ)へのマネジメント戦略．第 46 回日本口腔インプラント学会学術大会，名 古屋，2016．
8. 高岡一樹，西岡稔浩，阿部徹也，山村倫世，瀬川英美，野口一馬，浦出雅裕，岸本裕充．自然発症 2
型糖尿病ラットにおけるビスフォスフォネート関連顎骨壊死．第 59 日本口腔外科学会学術集会，千葉， 2014．
特許 受賞歴
主な所属学会等 1995 年〜
1996 年〜 2001 年〜 2004 年〜 2007 年〜 2008 年〜
日本口腔外科学会 日本口腔科学会 頭頸部癌学会 日本癌学会
日本口腔インプラント学会 日本顎顔面インプラント学会 研究資金獲得状況 2016〜2017 年
2015〜2017 年
2012〜2014 年
2009〜2011 年 内部
外部
外部
外部
研究助成金「骨微小環境における Hippo シグナルと TGF-βの関 与」(研究代表者)3,600 千円
科研費・基盤研究 C「骨微小環境における構造変化関連因子の 解明」(研究代表者)4,680 千円
科研費・基盤研究 C「組織内微小環境因子を標的とした骨治癒促 進効果」(研究代表者) 4,100 千円
高川
哲也
（タカガワ
テツヤ）
■所属部署
腸管病態解析学
(
炎症性腸疾患学講座内科部門兼任
)
■職名
特任助教
■学位
医学博士
研究分野 消化器内科学
主な研究テーマ 炎症性腸疾患の病態解明と新規治療法の開発
担当授業
学術論文 1. 中村 志郎, 佐藤 寿行, 河合 幹夫, 横山 陽子, 上小鶴 孝二, 髙川 哲也, 木田 裕子, 宮嵜 孝
子, 飯室 正樹, 樋田 信幸, 堀 和敏.コルチコステロイド.薬局 2016;67(6):19-25 株式会社南山堂
2. 中村 志郎, 堀 和敏, 樋田 信幸, 飯室 正樹, 宮嵜 孝子, 横山 陽子, 髙川 哲也, 上小鶴 孝
二, 河合 幹夫, 木田 裕子, 佐藤 寿行, 西尾 昭宏, 夏秋 優.抗TNR-α抗体製剤に起因する皮膚
病変.胃と腸 2016;51(8):1062-8 医学書院
3. 中村 志郎, 堀 和敏, 樋田 信幸, 飯室 正樹, 宮嵜 孝子, 横山 陽子, 髙川 哲也, 上小鶴 孝二,
河合 幹夫, 木田 裕子, 佐藤 寿行, 西尾 昭宏, 夏秋 優.抗TNR-α抗体製剤に起因する皮膚病 変.胃と腸 2016;51(8):1062-8 医学書院
4. 中村 志郎, 堀 和敏, 樋田 信幸, 飯室 正樹, 宮嵜 孝子, 横山 陽子, 上小鶴 孝二, 髙川 哲也,
河合 幹夫, 佐藤 寿行, 木田 裕子, 間島 行則.抗TNF-α抗体製剤をどう使うか-その治療戦略.消 化器の臨床 2015;18(4):361-8 株式会社ヴァンメディカル
5. Hori Kazutoshi, Ide Yoshi-Hiro, Hirota Seiichi, Toyoshima Fumihiko, Takagawa Tetsuya, Nakamura Shiro. Early gastric adenocarcinoma of the fundic gland type.Endoscopy 2015;47 Suppl 1 UCTN: E177-8
6. 中村志郎,樋田信幸,飯室正樹,宮嵜孝子,横山陽子,上小鶴孝二,中村美咲,奥順介,河合幹夫,佐藤寿
行,堀和敏,高川哲也.難治性潰瘍性大腸炎に対する抗TNF-α抗体療法の治療戦略.消化器内科
2014;58(6):722-29 科学評論社
7. 中村志郎,樋田信幸,飯室正樹,宮嵜孝子,横山陽子,高川哲也,上小鶴孝二,中村美咲,奥順介,河合幹 夫,佐藤寿行,堀和敏.治療指針・ガイドラインの実臨床への用い方．最新医学 2014;70:2:236-43 最 新医学社
8. 西尾 昭宏, 佐藤 寿行, 河合 幹夫, 上小鶴 孝二, 髙川 哲也, 木田 裕子, 横山 陽子, 宮嵜 孝
子, 樋田 信幸, 堀 和敏, 中村 志郎.Crohn病.消化器内視鏡.2017;29(1)36-45 株式会社東京医学
社
9. 樋田 信幸, 中村 志郎, 宮嵜 孝子, 横山 陽子, 髙川 哲也, 上小鶴 孝二, 河合 幹夫, 木田 裕
子, 佐藤 寿行, 堀 和敏.難治性潰瘍性大腸炎に対するadalimumab(完全ヒト型抗TNF-α抗体製剤) の臨床検討.Progress in Medicine 2016;36(12):1707-10
著書
主な学会発表 1. Kamikozuru Koji, SatoToshiyuki, KawaiMikio, TakagawaTetsuya, Kita Yuko, YokoyamaYoko, MiyazakiTakako, IimuroMasaki, HidaNobuyuki, Nakamura Shiro.Factors Associated With Restenosis and the Need for Surgical Interventions in Patients With Crohn’s Disease Undergoing Endoscopic Balloon Dilatation for Lower Gastrointestinal Strictures.Digestive Disease Week 2016(DDW2016) Poster Session 2016.5.23 SanDiego
2. Takagawa Tetsuya, Nakamura Shiro, Ivan J. Fuss, Warren Strober .LRRK2, a Susceptibility Gene of IBD Suppresses Autophagy Through Beclin-1 Inactivation.Digestive Disease Week 2016(DDW2016) Poster Session 2016.5.22 SanDiego
3. Miyazaki Takako, Nishio Akihiro, Sato Toshiyuki, Kawai Mikio, Kamikozuru Koji, Takagawa Tetsuya, Yokoyama Yoko, Iimuro Masaki, Hida Nobuyuki, Hori Kazutoshi, Nakamura Shiro.The endoscopic feature of relapse in ulcerative colitis treated with infliximab.The4rd Annual Meeting of Asian Organization for Crohn’s and Colitis(AOCC) Poster Exhibition 2016.7.8 Kyoto
4. Takagawa Tetsuya, Tajima Masaki, Kitani Atsushi, Nishio Akihiro, Sato Toshiyuki, Kawai Mikio, Yokoyama Yoko, Kita Yuko, Miyazaki Takako, Hida Nobuyuki, Hori Kazutoshi, Nakamura Shiro, Ivan Fuss, Warren Strober.Genetically-Determined Increases in LRRK2 Levels enhance susceptibility to colitis. The4rd Annual Meeting of Asian Organization for Crohn’s and Colitis(AOCC) Poster Oral 2016.7.9 Kyoto
5. 髙川 哲也, 佐藤 寿行, 河合 幹夫, 上小鶴 孝二, 横山 陽子, 木田裕子, 宮嵜 孝子, 飯室 正
樹, 樋田 信幸, 堀 和敏, Ivan Fuss, Warren Strober, 中村 志郎.IBDの感受性遺伝子LRRK2による
autophagyを介したBacterial killing制御.第53回日本消化器免疫学会総会 シンポジウム 2016.7.15
大阪
行, 木田 裕子, 西尾 昭宏, 堀 和敏.潰瘍性大腸炎入院症例における手術適応とタイミングに関する
臨床的検討.第71回日本大腸肛門病学会学術集会 パネルディスカッション 2016.11.18 伊勢
7. 髙川 哲也, 佐藤 寿行, 河合 幹夫, 横山 陽子, 宮嵜 孝子, 飯室正樹, 樋田 信幸, 堀 和敏,
Warren Strober, 中村 志郎.ポストGWAS時代の炎症性腸疾患治療：感受性遺伝子LRRK2を分子標
的とした新規治療法.第102回日本消化器病学会総会 (プレナリーセッション) 2016.4.21 東京
8. 上小鶴 孝二, 樋田 信幸, 中村 志郎, 佐藤 寿行, 河合 幹夫, 髙川 哲也, 横山 陽子, 宮嵜 孝
子, 飯室 正樹, 堀 和敏.若年Crohn病患者に対して長期間Infliximabを投与した検討.第102回日
本消化器病学会総会 (ポスター) 2016.4.22 東京
9. 木田 裕子, 間島 行則, 佐藤 寿行, 河合 幹夫, 上小鶴 孝二, 横山 陽子, 髙川 哲也, 宮嵜 孝
子, 飯室 正樹, 樋田 信幸, 堀 和敏, 中村 志郎.高齢者潰瘍性大腸炎入院例の臨床的検討.第
102回日本消化器病学会総会
10.宮嵜 孝子, 佐藤 寿行, 木田 裕子, 河合 幹夫, 上小鶴 孝二, 髙川 哲也, 横山 陽子, 飯室 正
樹, 樋田 信幸, 堀 和敏, 中村 志郎.難治性潰瘍性大腸炎におけるAdalimumabの治療成績の臨床
的検討.第102回日本消化器病学会総会 2016.4.22 東京 特許
受賞歴
主な所属学会等 日本内科学会
日本消化器病学会 日本消化器内視鏡学会 日本消化器免疫学会 国際粘膜免疫学会
研究資金獲得状況 2017～2020
2015～2018 2014～2015 2014～2015
外部 外部 外部 内部
科研費、基盤研究C (研究代表者) 3,250千円 科研費、基盤研究C (研究分担者) 1,850千円
鈴木謙三記念医科学応用研究財団 1,000千円
髙木
俊範
（タカギ
トシノリ）
■所属部署
脳神経外科
■職名
助教
■学位
医学博士
研究分野 脳血管障害、神経再生
主な研究テーマ 急性期脳梗塞に対する再開通療法、各種神経幹細胞を用いた神経再生療法
担当授業 神経系の疾患（脳神経外科分野）
学術論文 1. Takagi T, Yoshimura S, Uchida K, Shirakawa M, Yamada K, Tatebayashi K. The Current Status of Endovascular Thrombectomy for Acute Ischemic Stroke in Japan: Results of a Nationwide Questionnaire Survey in 2016. JNET. In press
2. Takagi T, Imai T, Mishiro K, Ishisaka M, Tsujimoto M, Ito H, Nagashima K, Matsukawa H, Tsuruma K, Shimazawa M, Yoshimura S, Kozawa O, Iwama T, Hara H: Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood–brain barrier. Journal of Cerebral Blood Flow & Metabolism. 37: 123–139, 2017.
3. Tatebayashi K, Tanaka Y, Nakano-Doi A, Sakuma R, Kamachi S, Shirakawa M, Uchida K, Kageyama H, Takagi T, Yoshimura S, Matsuyama T, Nakagomi T. Identification of multipotent stem cells in human brain tissue following stroke. Stem Cells Dev. 26(11):787-797, 2017
4. Sawada S, Ono Y, Egashira Y, Takagi T, Tsuruma K, Shimazawa M, Iwama T, Hara H. In models of intracerebral hemorrhage, rivaroxaban is superior to warfarin to limit blood brain barrier disruption and hematoma expansion. Curr Neurovasc Res. In press
5. Imai T, Mishiro K, Takagi T, Isono A, Nagasawa H, Tsuruma K, Shimazawa M, Hara H: Protective effect of bendavia (SS-31) against oxygen/glucose-deprivation stress-induced mitochondrial damage in human brain microvascular endothelial cells. Current Neurovascular Research. Curr Neurovasc Res. 14(1):53-59, 2017
6. Imai T, Matsukawa H, Takagi T, Tsuruma K, Shimazawa M, Hara H. The phosphodiesterase III inhibitor cilostazol protects the brain microvasculature from collagenase. Neuroreport. 28(10):555-560, 2017. 7. Shirakawa M, Yoshimura S, Uchida K, Shindo S, Yamada K, Kuroda J, Takagi T, Takada Y, Ishikura R.
Relationship between Hemorrhagic Complications and Target Vessels in Acute Thrombectomy. J Stroke Cerebrovasc Dis. In press
8. Imai T, Takagi T, Kitashoji A, Yamauchi K, Shimazawa M, Hara H: Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation. Neurobiology of Disease 89: 136-146, 2016
9. Takagi T, Yoshimura S, Uchida K, Enomoto Y, Egashira Y, Yamagami H, Sakai N: Intravenous tissue plasminogen activator before endovascular treatment increases symptomatic intracranial hemorrhage in patients with occlusion of the middle cerebral artery second division: Subanalysis of the RESCUE-Japan Registry. Neuroradiology 58:147–153, 2016
10.Yamauchi K, Nakano Y, Imai T, Takagi T., Tsuruma K, Shimazawa M, Iwama T, Hara H. A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice. Neuroscience 333: 302-10, 2016
11.Takagi T, Hara H: Protective effects of cilostazol against hemorrhagic stroke: current and future perspective. Journal of Pharmacological Sciences 131:155-61, 2016
12.Enomoto Y, Takagi, T., Matsubara H, Tsujimoto M, Yamauchi K, Yoshimura S, Iwama T: Delayed Stenosis in the Intracranial Vessels following Endovascular Treatment for Acute Stroke. J Vasc Interv Radiol 26:1814-9, 2015.
13.Takagi T, Kato T, Sakai H, Nishimura Y: Early Neurologic Improvement Based on the National Institutes of Health Stroke Scale Score Predicts Favorable Outcome within 30 Minutes after Undergoing Intravenous Recombinant Tissue Plasminogen Activator Therapy. Journal of Stroke and Cerebrovascular disease 23: 69-74, 2014
14.Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H: Diabetes Mellitus Aggravates Hemorrhagic Transformation after Ischemic Stroke via Mitochondrial Defects Leading to Endothelial Apoptosis. PLoS One 18;9(8):e103818, 2014. 15.Takagi T, Kitashoji A, Iwawaki T, Tsuruma K, Shimazawa M, Yoshimura S, Iwama T, Hara H: Temporal
activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury. Free Radic Biol Med 72:124-33, 2014
cerebral ischemia-reperfusion injury. Neuroscience 277:123-131, 2014
17.Takagi T, Mishiro K, Shimazawa M, Yoshimura S, Iwama T, Hara H: The phosphodiesterase III inhibitor cilostazol ameliorates ethanol-induced endothelial dysfunction. Curr Neurovasc Res 11: 302-311, 2014 18.Egashira Y, Suzuki Y, Azuma Y, Takagi T, Mishiro K, Sugitani S, Tsuruma K, Shimazawa M, Yoshimura
S, Kashimata M, Iwama T, and Hara H: The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. Journal of Neuroinflammation 10:105, 2013
19.Suzuki Y, Nakano Y, MishiroK, Takagi T, Tsuruma K, Nakamura M, Yoshimura S, Shimazawa M, Hara H: Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke. Sci Rep 3: 3177, 2013
20.Nishikawa Y, Satow T, Takagi T, Murao K, Miyamoto S, Iihara K: Efficacy and Safety of Single versus Dual Antiplatelet Therapy for coiling of unruptured aneurysms. J Stroke Cerebrovasc Dis 22:650-655, 2013
21.Kato T, Sakai H, Takagi T, Nishimura Y: Cilostazol prevents progression of asymptomatic carotid artery stenosis in patients with contralateral carotid artery stenting. Am J Neuroradiol 33(7):1262-6, 2012
22.Takagi T, Yoshimura S, Yamada K, Enomoto Y, Iwama T: Angioplasty and stenting of totally occluded common carotid artery at the chronic stage. Neurol Med Chir (Tokyo) 50:998-1000, 2010
23.松原博文、榎本由貴子、辻本真範、高木俊範、吉村紳一、岩間亨, 頚動脈内膜剥離術と冠動脈バイ
パス術の一期的手術の有用性. 脳卒中の外科 45: 121-125, 2017
24.三輪和弘, 高木俊範, 吉村和也, 篠田淳, 中山則之, 矢野大仁, 岩間亨, 悪性神経膠腫に対する
ベバシズマブの使用経験―放射線治療後の占拠性病変に対する治療効果について―. 定位的放射
線治療20:67-76, 2016
25.松原博文, 髙木俊範, 榎本由貴子, 岩間亨: くも膜下出血にて発症した頚髄radicular AVFの1例. 脳神経外科ジャーナル 25:683-687, 2016
26.榎本由貴子, 吉村紳一, 髙木俊範, 辻本真範, 石澤錠二, 岩間亨: 緊急脳血管内治療時における 抗血小板薬loading dose投与後の薬効解析. JNET 8:75-82, 2014
27.髙木俊範, 師田信人, 井原哲, 金子剛, 矢状縫合早期癒合症における術後の形態学的評価とその
変化. Nervous System in Children 35:527-532, 2010
28.岩間亨, 吉村紳一, 矢野大仁, 大江直行, 榎本由貴子, 山田清文, 高木俊範: 脳動静脈奇形摘出 術の基本戦略. 脳卒中の外科 37:390-394, 2009
29.榎本由貴子, 吉村紳一, 山田清文, 高木俊範, 岩間亨: 頸部頸動脈ステント留置術における術前血
小板凝集能測定の有用性. JNET 2(3) 188-192, 2008
著書 1. 高木俊範, 吉村紳一: 椎骨脳底動脈瘤IVRのトラブルシューティング 前大脳動脈瘤・椎骨脳底動脈
瘤のすべて 335-34, メディカ出版: 東京, 2016
2. 高木俊範, 吉村紳一: 脳動脈瘤・脳動静脈奇形/脳動静脈瘻に対するカテーテル治療. 診断と治療
104(9):1137-1143, 診断と治療社: 東京, 2016
3. 髙木俊範, 脳血管内治療トラブルシューティング脳虚血編102-107, 診断と治療社: 東京, 2015
4. 髙木俊範, 吉村紳一: 急性期脳梗塞に対する新しい再灌流療法. 循環器疾患 最新の治療,
2014-2015:29-33, 南江堂, 2014
5. 髙木俊範, 脳血管内治療トラブルシューティング脳動脈瘤編10-27, 診断と治療社: 東京, 2014
主な学会発表 1. 髙木俊範、内田和孝、吉村紳一: 急性再開通療法に関する全国アンケート調査結果（シンポジウム）、
第32回日本脳神経血管内治療学会総会, 神戸, 2016
2. Takagi T, Yoshimura S, Enomoto Y, Egashira Y, Yamagami H., Sakai N., Okada Y, Kitagawa K, Kimura K, Tanahashi N, Hyougo T: Does Intravenous t-PA Before Acute Stroke Intervention Increase Intracranial Hemorrhage? -subanalysis Of Rescue-japan Registry. International Stroke Conference, Nashville, USA, 2015
3. 髙木俊範, 今井貴彦, 三代圭祐, 石坂光絵, 松川悠, 鶴間一寛, 嶋澤雅光, 吉村紳一, 岩間亨, 原
英彰: Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood brain
barrier. 第27回日本脳循環代謝学会総会, 富山, 2015
4. 髙木俊範, 村井博文, 榎本由貴子, 岩間亨, 非特異的CASの1例. 第43回日本脳神経血管内治 療学会中部地方会, 名古屋, 2015
5. 髙木俊範, 北庄司輝, 岩脇隆夫, 鶴間一寛, 嶋澤雅光, 吉村紳一, 岩間亨, 原英彰: 脳虚血再灌
流障害における転写因子Nrf2の活性化およびNrf2活性化剤による神経保護の検討. 第39回日本脳
卒中学会総会, 大阪, 2014
6. 髙木俊範, 吉村紳一, 榎本由貴子, 江頭裕介, 岩間亨, 山上宏, 坂井信幸, 岡田靖, 北川一夫, 木
村和美, 棚橋紀夫, 瓢子敏夫: 術前t-PA静注療法が急性期再開通療法後出血に与える影響－
RESCUE-Japan Registryより－. 第30回日本脳神経血管内治療学会総会, 横浜, 2014
7. 髙木俊範, 三代圭祐, 今井貴彦, 嶋澤雅光, 岩間亨, 原英彰: エタノール誘発血管内皮障害に対す
るシロスタゾールの保護作用. 第26回日本脳循環代謝学会総会, 岡山, 2014
8. Takagi T: WFNS Workshops and Educational Course. Lippo Karawaci, Indonesia, 2013
10.髙木俊範, 佐藤徹, 高田茂樹, 高崎盛生, 阿部悟朗, 賀来泰之, 福田健治, 伊藤要, 松重俊憲, 森
久恵, 片岡大治, 中嶌教夫, 飯原弘二: 未破裂脳動脈瘤コイル塞栓術における抗血小板薬療法に
関する検討：術前評価と継続期間. 第36回脳卒中の外科学会, 福岡, 2011
11.高木俊範, 加藤貴之, 酒井秀樹, 西村康明: Occipital sinusのみにshunt pointを認めた dAVFの1
例：解剖学的考察および治療戦略について. 第27回NPO法人日本脳神経血管内治療学会学術総
会, 千葉, 2011
12.高木俊範, 加藤貴之, 酒井秀樹, 西村康明: rt-PA静注療法無効例に対しIVRでの追加治療を行っ
た3例：当センターにおける治療方針. 第27回NPO法人日本脳神経血管内治療学会学術総会, 千
葉, 2011 特許
受賞歴 第73回脳神経外科学会中部支部会優秀論文賞, 2007
主な所属学会等 2006年8月～
2007年6月～
2008年5月～
2009年2月～
2010年3月～
2014年11月～
2007年10月～
日本脳神経外科学会 日本脳神経血管内治療学会 日本脳神経外科学会コングレス 日本脳卒中の外科学会 日本脳卒中学会 日本脳循環代謝学会 日本小児脳神経学会
研究資金獲得状況 2016～2018 年
2015～2016年
2013～2014年
2016年
外部
外部
外部
外部
平成28年度日本医療研究開発機構研究費「再生医療実現拠
点ネットワークプログラム（幹細胞・再生医学イノベーション 創出プログラム）」「ヒト脳傷害誘導性神経幹細胞を用いた神
経再生療法」（研究代表者）39,000 千円
日本学術振興会科学研究費補助金 若手研究(B)「Nrf2活性化
による脳虚血再灌流障害の軽減と治療可能時間の延長」 （研究代表者）3,770千円
科学研究費助成事業 t-PA静注療法の未来への探求（研究
代表者）5,000千円
公益財団法人 先進医薬研究振興財団 ヒト脂肪組織由来幹
高木
治行
（タカキ
ハルユキ）
■所属部署
放射線医学
■職名
学内講師
■学位
医学博士
研究分野 放射線医学 主な研究テーマ がんに対するIVR
担当授業 消化器系の疾患（肝・胆・膵の疾患）
学術論文 (総説)
1. Miyazaki M, Iguchi T, Takaki H, Yamanaka T, Tamura Y, Tokue H, Sato Y, Ikeda O, Shimizu T, Yamakado K. Ablation protocols and ancillary procedures in tumor ablation therapy: consensus from Japanese experts. Jpn J Radiol. 2016 Sep;34(9):647-56.
2.Takaki H, Cornelis F, Kako Y, Kobayashi K, Kamikonya N, Yamakado K. Thermal ablation and immunomodulation: From preclinical experiments to clinical trials. Diagn Interv Imaging. 2017 in press.
(原著)
1. Inaba Y, Arai Y, Ino S, Matsueda K, Aramaki T, Takaki H, Transcatheter arterial embolization for external iliac artery hemorrhage associated with infection in postoperative pelvic malignancy. J Vasc Interv Radiol, 15, 283-7, 2004
2. Nakatsuka A, Yamakado K, Maeda M, Yasuda M, Akeboshi M, Takaki H, Hamada A, Takeda K, Radiofrequency ablation combined with bone cement injection for the treatment of bone malignancies. J Vasc Interv Radiol, 15, 707-1, 2004
3. Oshima F, Yamakado K, Akeboshi M, Takaki H, Nakatsuka A, Makita M, Takeda K, Lung radiofrequency ablation with and without bronchial occlusion: experimental study in porcine lungs. J Vasc Interv Radiol, 15, 1451-6, 2004
4. Hamada A, Yamakado K, Nakatsuka A, Takaki H, Akeboshi M, Takeda K, Hepatic arterial infusion chemotherapy with use of an implanted port system in patients with advanced hepatocellular carcinoma: prognostic factors. J Vasc Interv Radiol, 15, 835-41, 2004
5. Yamakado K, Nakatsuka A, Takaki H, Mori Y, Tonouchi H, Kusunoki M, Kida H, Takeda K, Prospective study of arterial infusion chemotherapy followed by radiofrequency ablation for the treatment of liver metastasis of gastric cancer. J Vasc Interv Radiol, 16, 1747-5, 2005
6. Yamakado K, Nakatsuka A, Akeboshi M, Takaki H, Takeda K, Percutaneous radiofrequency ablation for the treatment of liver neoplasms in the caudate lobe left of the vena cava: electrode placement through the left lobe of the liver under CT-fluoroscopic guidance. Cardiovasc Intervent Radiol, 28, 638-40, 2005
7. Yamakado K, Nakatsuka A, Kobayashi S, Akeboshi M, Takaki H, Kariya Z, Kinbara H, Arima K, Yanagawa M, Hori Y, Kato H, Sugimura Y, Takeda K, Radiofrequency ablation combined with renal arterial embolization for the treatment of unresectable renal cell carcinoma larger than 3.5 cm: initial experience. Cardiovasc Intervent Radiol, 29, 389-94, 2006
8. Hamada A, Yamakado K, Nakatsuka A, Takaki H, Takeda K, Clinical utility of coaxial reservoir system for hepatic arterial infusion chemotherapy. J Vasc Interv Radiol, 18, 1258-63, 2007 9. Ii N, Yamakado K, Shouji K, Nomoto Y, Nakatsuka A, Nomura M, Yamashita Y, Takaki H, Akeboshi
M, Senga M, Shiraki K, Takeda K, Multimodality therapy using brachytherapy for caval tumor of hepatocellular carcinoma. Hepatogastroenterology, 54, 1522-1525, 2007
10. Takaki H, Yamakado K, Nakatsuka A, Fuke H, Murata K, Shiraki K, Takeda K, Radiofrequency ablation combined with chemoembolization for the treatment of hepatocellular carcinomas 5 cm or smaller: risk factors for local tumor progression. J Vasc Interv Radiol, 18, 856-61, 2007 11. Yamakado K, Hase S, Matsuoka T, Tanigawa N, Nakatsuka A, Takaki H, Takao M, Inoue Y,
Kanazawa S, Inoue Y, Sawada S, Kusunoki M, Takeda K, Radiofrequency ablation for the treatment of unresectable lung metastases in patients with colorectal cancer: a multicenter study in Japan. J Vasc Interv Radiol, 18, 393-8, 2007
12. Makita M, Yamakado K, Nakatsuka A, Takaki H, Inaba T, Oshima F, Katayama H, Takeda K, Effects of barium concentration on the radiopacity and biomechanics of bone cement: experimental study. Radiat Med. 26, 533-8, 2008
antenna. Radiat Med, 26, 408-14, 2008
14. Nakatsuka A, Yamakado K, Takaki H, Uraki J, Makita M, Oshima F, Takeda K. Cardiovasc Intervent Radiol, Percutaneous radiofrequency ablation of painful spinal tumors adjacent to the spinal cord with real-time monitoring of spinal canal temperature: a prospective study. 32, 70-5, 2009
15. Fuke H, Sugimoto K, Shiraki K, Tanaka J, Beppu T, Yoneda K, Yamamoto N, Ito K, Takaki H, Nakatsuka A, Yamakado K, Takeda K, Takei Y, Predictive factors for distant recurrence of HCV-related hepatocellular carcinoma after radiofrequency ablation combined with chemoembolization. Aliment Pharmacol Ther, 27, 1253-60, 2008
16. Yamakado K, Nakatsuka A, Takaki H, Yokoi H, Usui M, Sakurai H, Isaji S, Shiraki K, Fuke H, Uemoto S, Takeda K, Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy. Radiology, 247, 260-6, 2008
17. Nomura M, Yamakado K, Nomoto Y, Nakatsuka A, Ii N, Takaki H, Yamashita Y, Takeda K, Complications after lung radiofrequency ablation: risk factors for lung inflammation. Br J Radiol., 81, 244-9, 2008
18. Soga N, Yamakado K, Gohara H, Takaki H, Hiraki T, Yamada T, Arima K, Takeda K, Kanazawa S, Sugimura Y, Percutaneous radiofrequency ablation for unresectable pulmonary metastases from renal cell carcinoma. BJU Int., 104, 790-4, 2009
19. Takaki H, Yamakado K, Uraki J, Nakatsuka A, Fuke H, Yamamoto N, Shiraki K, Yamada T, Takeda K, Radiofrequency ablation combined with chemoembolization for the treatment of hepatocellular carcinomas larger than 5 cm. J Vasc Interv Radiol, 20, 217-24, 2009
20. Yamakado K, Anai H, Takaki H, Sakaguchi H, Tanaka T, Kichikawa K, Takeda K, Adrenal metastasis from hepatocellular carcinoma: radiofrequency ablation combined with adrenal arterial
chemoembolization in six patients. AJR Am J Roentgenol, 192, 300-5, 2009
21. Yamakado K, Inoue Y, Takao M, Takaki H, Nakatsuka A, Uraki J, Kashima M, Kusunoki M, Shimpo H, Takeda K. Long-term results of radiofrequency ablation in colorectal lung metastases: single center experience. Oncol Rep, 22, 885-91, 2009
22. Takaki H, Yamakado K, Nakatsuka A, Uraki J, Usui M, Sahurai H, Isaji S, Takeda K, Stent placement for portal venous stenosis following major abdominal surgery. Hepatogastroenterology, 56, 407-10, 2009
23. Nakamura T, Matsumine A, Yamakado K, Matsubara T, Takaki H, Nakatsuka A, Takeda K, Abo D, Shimizu T, Uchida A, Lung radiofrequency ablation in patients with pulmonary metastases from musculoskeletal sarcomas [corrected]. Cancer, 15, 3774-81, 2009
24. Beppu T, Sugimoto K, Shiraki K, Tameda M, Kusagawa S, Nojiri K, Tanaka J, Yamamoto N, Takei Y, Takaki H, Uraki J, Nakatsuka A, Yamakado K, Takeda K, Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation, Int J Mol Med, 26, 425-33, 2010
25. Takaki H, Yamakado K, Soga N, Nakatsuka A, Yamanaka T, Arima K, YamadaT, Takeda K, Sugimura Y, Midterm Results of T1a Renal Cell Carcinoma: Radiofrequency Ablation versus Nephrectomy. Jpn J Radiol, 28, 460-8, 2010
26. Yamao Y, Yamakado K, Takaki H, Yamada T, Murashima S, Uraki J, Kodama H, Nagasawa N, Takeda K, Optimal scan parameters for CT fluoroscopy in lung interventional radiologic procedures: relationship between radiation dose and image quality, Radiology, 255, 233-41, 2010 27. Kashima M, Yamakado K, Takaki H, Kaminou T, Tanigawa N, Nakatsuka A, Takeda K,
Radiofrequency ablation for the treatment of bone metastases from hepatocellular carcinoma. AJR Am J Roentgenol, 194, 536-4, 2010
28. Yamakado K, Nakatsuka A, Takaki H, Sakurai H, Isaji S, Yamamoto N, Shiraki K, Takeda K, Subphrenic versus nonsubphrenic hepatocellular carcinoma: combined therapy with chemoembolization and radiofrequency ablation. AJR Am J Roentgenol, 194, 530-5, 2010 29. Yamakado K, Takaki H, Nakatsuka A, Kashima M, Uraki J, Yamanaka T, Takeda K, Percutaneous
transhepatic drainage of inaccessible abdominal abscesses following abdominal surgery under real-time CT-fluoroscopic guidance. Cardiovasc Intervent Radiol, 33, 161-3, 2010
30. Yamakado K, Takaki H, Takao M, Murashima S, Kodama H, Kashima M, Nakatsuka A, Uraki J, Shimpo H, Takeda K, Massive hemoptysis from pulmonary artery pseudoaneurysm caused by lung radiofrequency ablation: successful treatment by coil embolization. Cardiovasc Intervent Radiol, 33, 410-2, 2010
31. Takaki H, Yamakado K, Nakatsuka A, Yamada T, Uraki J, Kashima M, Yamanaka T, Shiraki K, Takei Y, Takeda K, Computed tomography fluoroscopy-guided radiofrequency ablation following intra-arterial iodized-oil injection for hepatocellular carcinomas invisible on ultrasonographic images, Int J Clin Oncol, 18, 46-53, 2011
32. Kashima M, Yamakado K, Takaki H, Kodama H, Yamada T, Uraki J, Nakatsuka A, Complications after 1000 lung radiofrequency ablation sessions in 420 patients: a single center's experiences, AJR Am J Roentgenol, 197, 576-80, 2011
