[PDF] Top 20 April 2008 March 2009 Financial Report | IRライブラリー | 株主・投資家の皆様へ | アマノ
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Alternation of the pharmacokinetics of theophyline by rutaecarpine, an alkaloid of the medical herb Evodia rutaecarpa, in rats.
... increase in EROD activity. In the lungs, EROD activity was elevated from an undetectable to a detectable level by ...parameters of theophylline were determined using a ... 完全なドキュメントを参照
Alternation of the pharmacokinetics of theophyline by rutaecarpine, an alkaloid of the medical herb Evodia rutaecarpa, in rats.
... evaluate the pharmacokinetic interaction of theophylline with rutaecarpine, the effects of rutaecarpine on CYP1A2 activity and theophylline pharmacokinetics were ... 完全なドキュメントを参照
Alteration of the pharmacokinetics of the theophylline by rutaecarpine, an alkaloid of the medical herb Evodia rutaecarpa, inrats
... theophylline pharmacokinetics were investigated. Oral treatment of Sprague-Dawley rats with 50 mg kg-1 rutaecarpine for 3 days through a gastrogavage caused a 4- and 3-fold increase in ... 完全なドキュメントを参照
1
Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from evodia rutaecarpa. Eur.
... In addition, rutaecarpine (40-200 microM) did not significantly affect cyclic AMP and cyclic GMP levels in human washed platelets, whereas it significantly inhibited thromboxane B2 for[r] ... 完全なドキュメントを参照
3
The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C.
... to the inhiother hand, rutaecarpine (50 and 100 mM) dose- bition of phospholipase C activity, leading to redependently inhibited the increase in intracellular duce phosphoinositide ... 完全なドキュメントを参照
The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C.
... Abstract In this study, the mechanism involved in the anti- affect nitrate production in collagen (10 mg/ml)-platelet activity of rutaecarpine in human platelet ... 完全なドキュメントを参照
The antiplatelet activity of rutaecarpine, an alkaloid isolated from evodia rutaecarpa, is mediated through inhibition of phospholipase C.
... It is concluded that the antiplatelet activity of rutaecarpine may possibly be due to the inhibition of phospholipase C activity, leading to reduce phosphoinositide breakdown, followed[r] ... 完全なドキュメントを参照
2
Cardiovascular Pharmacological Actions of Rutaecarpine, a Quinazolinocarboline Alkaloid Isolated From Evodia rutaecarpa
... is the most common cause of death in the United States, with about 2 million deaths per year attrib- utable to such conditions as myocardial infarction, pulmonary embolism, and cerebrovascular ... 完全なドキュメントを参照
1
Metabolic pharmacokinetics of isoflavones in the roots of Pueraria lobata in rats
... Quantitation of isoflavones and their conjugated metabolites in serum Serum was deproteinized by the addition of a 4-fold volume of ...methanol. The supernatant was ... 完全なドキュメントを参照
4
Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim extract on the pharmacokinetics of sildenafil in rats
... sagittatum. In fact, we tried to demonstrate the actual clinical scenario regarding the daily life of Chinese culture in this ...study. In Traditional Chinese Medicine, people ... 完全なドキュメントを参照
1
Interaction of Acupuncture and Electroacupuncture on the Pharmacokinetics of Aspirin and the Effect of Brain Blood Flow in Rats
... improve the brain and motor functions of post-stroke patients, and aspirin is used for the prevention of stroke recurrence in Western ...produce an interaction with treatment ... 完全なドキュメントを参照
2
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes
... Among these alkaloids, rutaecarpine showed the most potent and selective inhibitory effect on CYP1A-catalyzed 7-methoxyresorufin O-demethylation (MROD) and 7-ethoxyresorufin O-deethyla[r] ... 完全なドキュメントを参照
2
Flavonoid Pharmacokinetics and Tissue Distribution after Repeated Dosing of the Roots of Scutellaria baicalensis in Rats
... forms of baicalein and wogonin have been detected. The concentrations of the glucuronides and glucu- ronides/sulfates of baicalein and wogonin were determined indi- rectly after ... 完全なドキュメントを参照
16
Quantitatively Evaluation of Bioactive Components of Evodia rutaecarpa (Tetradium ruticarpum) in different Harvesting Times
... During the season of flower and unripe fruit, the contents of dehydroevodiamine (I), evodiamine (II), and rutaecarpine (III) were found to increase with the development time of flower [r] ... 完全なドキュメントを参照
1
Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice
... Abstract Evodia rutaecarpa is a traditional Chinese medicine used for the treatment of gastrointestinal disorders and ...assess the possible drug interactions, effects of ... 完全なドキュメントを参照
40
Anti-Cancer Effects of Coptis chinensis and Evodia rutaecarpa in HepG2 Cells and in an Orthotopic Intrahepatic Xenograft Model
... Institute Of Chinese Medicine, China Medical University, Taichung, Taiwan, 2 School Of Medicine, Chung- Shan Medical University, Taichung, Taiwan, 3 Institute Of Occupational Medicine ... 完全なドキュメントを参照
1
A Chinese Herb Formula decreases the monocarboxylate transporter-mediated absorption of valproic acid in rats
... approved by the Institutional Animal Care and Use Committee of China Medical University, ...Taiwan. Rats weighing 430-520 g were fasted 12 h before experiment. In each study, ... 完全なドキュメントを参照
6
Effects of a P-glycoprotein modulator on the pharmacokinetics and distribution of free levobupivacaine and bupivacaine in rats
... approved by the institutional animal experimentation com- mittee of the National Yang-Ming University, Taipei, ...Sprague–Dawley rats weighing 300–350 g were obtained from the ... 完全なドキュメントを参照
2
Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction
... substrate of P-gp and CYP 2C , it is reasonable to assume that RP may induce P-gp or CYP 2C and thus resulting in the decreased absorption of ...However, the unaffected ratio of ... 完全なドキュメントを参照
1
Different Influences on Tacrolimus Pharmacokinetics by Coadministrations of Zhi Ke and Zhi Shi in Rats
... subsequently the residuals metabolized by CYP3A4 in intestine and liver ...absorption of tacrolimus may be associated with the activation of P-gp and/or ...explore the ... 完全なドキュメントを参照
1
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