[PDF] Top 20 平成19年3月期（第91期）中間報告書 事業報告書 | IRライブラリー | 株主・投資家の皆様へ | アマノ
Has 10000 "平成19年3月期（第91期）中間報告書 事業報告書 | IRライブラリー | 株主・投資家の皆様へ | アマノ" found on our website. Below are the top 20 most common "平成19年3月期（第91期）中間報告書 事業報告書 | IRライブラリー | 株主・投資家の皆様へ | アマノ".
Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway.
... explore the molecular mechanisms involved in Aß-induced OLG death, examining the potential role of ceramide, a known apoptogenic ...and ceramide induced OLG death. In addition, ... 完全なドキュメントを参照
Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway.
... explore the molecular mechanisms involved in Aß-induced OLG death, examining the potential role of ceramide, a known apoptogenic ...and ceramide induced OLG death. In addition, ... 完全なドキュメントを参照
Peptidoglycan Induces Cyclooxygenase-2 Expression in Macrophages by Activating the Neutral Sphingomyelinase-Ceramide Pathway
... increased ceramide generation. PGN-induced nSMase activation and ceramide formation were inhibited by 3-OMS, but not by ...inhibited by a p38 MAPK inhibitor (SB 203580) and dominant ... 完全なドキュメントを参照
Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide.
... explored the molecular mechanism underlying amyloid beta-peptide (Abeta)-mediated cytotoxicity in ...cell death. Ceramide is a pro-apoptotic lipid ...cellular ceramide ... 完全なドキュメントを参照
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Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes.
... that the amyloid beta peptide (Aβ) induces apoptosis in oligodendrocytes (OLG), via activation of neutral sphingomyelinase (nSMase) and resultant generation of ...In ... 完全なドキュメントを参照
Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes.
... of ceramide. In the current study, we report that both Aβ and ceramide increased expression of the proapoptotic protein DP5/Hrk (DP5), and release of cytochrome C from mitochondria to ... 完全なドキュメントを参照
Peptidoglycan Induces Cyclooxygenase-2 Expression in Macrophages by Activating the Neutral
... conclusion, the findings of our study for the first time show that PGN might activate nSMase, but not aSMase, to induce ceramide formation, which in turn initiates MKK3/6, p38 MAPK, and NF- B ... 完全なドキュメントを参照
Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death.
... Suppression of PP2A activity by RNA interference or a specific inhibitor, okadaic acid, effectively suppressed Abeta-induced Akt inactivation and FKHRL1 activation, leading to an atten[r] ... 完全なドキュメントを参照
2
Neutral Sphingomyelinase
... acid sphingomyelinase (aSMase) 抑制劑 (imipramine) 所抑制。以 PGN 刺激細胞會造成 PKC 活性增加，此作用會被 D609, Go 6976 和 Ro 31-8220 所抑制，但卻不被 U-73122 所影響。另外 PGN 會有時間相關性的增加 nSMase 活性及造成 ceramide 的產生，但卻不影響 aSMase 的活性；PGN 所誘導的 nSMase ... 完全なドキュメントを参照
Amyloid beta peptide-activated signal pathways in human platelets
... causes. Amyloid-β may activate or potentiate platelet aggregation. The present study explored the signaling events that underlie amyloid-β activation of platelet ...examine the ... 完全なドキュメントを参照
1
Amyloid beta peptide-activated signal pathways in human platelets
... causes. Amyloid-β may activate or potentiate platelet aggregation. The present study explored the signaling events that underlie amyloid-β activation of platelet ...examine the ... 完全なドキュメントを参照
1
Expression of amyloid beta peptide in human platelets: Pivotal role of the phospholipase Cgamma2-protein kinase C pathway in platelet activation.
... Exogenous Abeta (2-10 microM) stimulated platelet aggregation accompanied by phospholipase Cgamma2 (PLCgamma2) phosphorylation, phosphoinositide breakdown, and [Ca(2+)]i mobilization [r] ... 完全なドキュメントを参照
2
Expression of amyloid beta peptide in human platelets: pivotal role of the phospholipase Cγ2-protein kinase C pathway in platelet activation
... Abstract The amyloid  peptide (A), a mediator of neuronal and vascular degeneration in the pathogenesis of Alzheimer’s disease and cerebral amyloid angiopathy may have peripheral ... 完全なドキュメントを参照
57
Amyloid beta peptide-activated signal pathways in human platelets.
... from the present study demonstrate for the first time the activation of the PAR1-Ras-PI3-kinase-Akt-p38 MAPK-cPLA 2 - TxA 2 cascades in amyloid- β-induced platelet ...activation. ... 完全なドキュメントを参照
2
Expression of amyloid beta peptide in human platelets: Pivotal role of phospholipase Cgamma2-protein kinase C pathway in platelet activation
... Exogenous Abeta (2-10 microM) stimulated platelet aggregation accompanied by phospholipase Cgamma2 (PLCgamma2) phosphorylation, phosphoinositide breakdown, and [Ca(2+)]i mobilization [r] ... 完全なドキュメントを参照
3
Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide
... to the cytotoxic action of A  when incubated in a medium that enriches cholesterol levels of the surface ...on the plasma membrane readily, which acted as seeds and increased the accumulation ... 完全なドキュメントを参照
2
Amyloid beta induces Smac release via AP-1/Bim activation.
... for the Study of Nervous System Injury, Washington University School of Medicine, ...of amyloid- peptide (A) are the major component of senile and vascular plaques found in the brains ... 完全なドキュメントを参照
Amyloid beta induces Smac release via AP-1/Bim activation.
... for the Study of Nervous System Injury, Washington University School of Medicine, ...of amyloid- peptide (A) are the major component of senile and vascular plaques found in the brains ... 完全なドキュメントを参照
Protective effects of Angelica sinensis extract on amyloid beta-peptide-induced neurotoxicity.
... The AS extract protected cell viability against Abeta-induced oxidative damage (ROS, TBARS, and GSH contents) and rescued the DeltaPsim levels in a dose-dependent manner: the dosages o[r] ... 完全なドキュメントを参照
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Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway
... from the present studies establish a series of sequential events entailing A β activation of GSK-3β which in turn phosphor- ylates SC35 to alter tau exon 10 splicing, resulting in an increase in the tau ... 完全なドキュメントを参照
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