Publications from Juntendo University Graduate School of Medicine, 2018 [6/6]
Intractable Disease Research Center 〈Original Articles〉
1）Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S: Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 path-way in pancreatic NETs. Endocr Relat Cancer, 2018; 25: 619-631.
2）Asano K, Suzuki T, Saito A, Wei FY, Ikeuchi Y, Numata T, Tanaka R, Yamane Y, Yama-moto T, Goto T, Kishita Y, Murayama K, Ohtake A, Okazaki Y, Tomizawa K, Saka-guchi Y, Suzuki T: Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease. Nucleic Acids Res, 2018; 46: 1565-1583. 3）Chiyonobu N, Shimada S, Akiyama Y,
Mogushi K, Itoh M, Akahoshi K, Matsumura S, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Suganami T, Yamaoka S, Ogawa Y, Tanabe M, Tanaka S: Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intra-tumoral Hepatic Stellate Cells within Hepato-cellular Carcinoma with Metabolic Risk Factors. Am J Pathol, 2018; 188: 1213-1224. 4）Grant EJ, Cologne JB, Sharp GB, Eguchi H,
Stevens RG, Izumi S, Kim YM, Berrington de González A: Bioavailable serum estradiol may alter radiation risk of postmenopausal breast cancer: a nested case-control study. Int J Radiat Biol, 2018; 94: 97-105.
5）Hayashi T, Takamochi K, Yanai Y, Mitani K, Tomita H, Mogushi K, Suehara Y, Takahashi F, Suzuki K, Saito T, Yao T: Non-small cell lung carcinoma with diffuse coexpression of thyroid transcription factor-1 and ΔNp63/ p40. Hum Pathol, 2018; 78: 177-181.
6）Yamauchi H, Nakagawa C, Kobayashi M, Kobayashi Y, Mano T, Nakamura S, Arai M: Cost-effectiveness of surveillance and pre-vention strategies in BRCA1/2 mutation carriers. Breast Cancer, 2018; 25: 141-150. 7）Yamauchi H, Okawa M, Yokoyama S,
Naka-gawa C, Yoshida R, Suzuki K, Nakamura S, Arai M: High rate of occult cancer found in prophylactic mastectomy specimens despite thorough presurgical assessment with MRI and ultrasound: findings from the Hereditary Breast and Ovarian Cancer Registration 2016 in Japan. Breast Cancer Res Treat, 2018; 172: 679-687.
8）Hirasaki M, Ueda A, Asaka MN, Uranishi K, Suzuki A, Kohda M, Mizuno Y, Okazaki Y, Nishimoto M, Sharif J, Koseki H, Okuda A: Identification of the Coiled-Coil Domain as an Essential Methyl-CpG-Binding Domain Pro-tein 3 Element for Preserving Lineage Commitment Potential of Embryonic Stem Cells. Stem Cells, 2018; 36: 1355-1367. 9）Horimoto Y, Tanabe M, Kazuno S, Miura Y,
Mogushi K, Sonoue H, Arakawa A, Kajino K, Kobayashi T, Saito M: Elucidation of inhibi-tory effects on metastatic sentinel lymph nodes of breast cancer during One-Step Nucleic Acid Amplification. Sci Rep, 2018; 8: 7563. 10）Imai-Okazaki A, Kishita Y, Kohda M, Yatsuka
Y, Hirata T, Mizuno Y, Harashima H, Hirono K, Ichida F, Noguchi A, Yoshida M, Tokoro-dani C, Nishiuchi R, Takeda A, Nakaya A, Sakata Y, Murayama K, Ohtake A, Okazaki Y: Barth Syndrome: Different Approaches to Diagnosis. J Pediatr, 2018; 193: 256-260. ＊11）Kuwabara K, Suzuki O, Chika N, Kumamoto
K, Minabe T, Fukuda T, Arai E, Tamaru JI, Akagi K, Eguchi H, Okazaki Y, Ishida H: Prevalence and molecular characteristics of An asterisk (＊) denotes doctoral works by Japanese students.
A dugger (†) denotes doctoral works by non-Japanese students.
This is a reprint of content originally published in Juntendo University HP.
DNA mismatch repair protein-deficient seba-ceous neoplasms and keratoacanthomas in a Japanese hospital-based population. Jpn J Clin Oncol, 2018; 48: 514-521.
＊12）Kado M, Tanaka R, Arita K, Okada K, Ito-Hirano R, Fujimura S, Mizuno H: Human peripheral blood mononuclear cells enriched in endothelial progenitor cells via quality and quantity controlled culture accelerate vascu-larization and wound healing in a porcine wound model. Cell Transplant, 2018; 27: 1068-1079.
13）Martin CA, Sarlós K, Logan CV, Thakur RS, Parry DA, Bizard AH, Leitch A, Cleal L, Ali NS, Al-Owain MA, Allen W, Altmüller J, Aza-Carmona M, Barakat BAY, Barraza-García J, Begtrup A, Bogliolo M, Cho MT, Cruz-Rojo J, Dhahrabi HAM, Elcioglu NH; GOSgene, Gorman GS, Jobling R, Kesterton I, Kishita Y, Kohda M, Le Quesne Stabej P, Malallah AJ, Nürnberg P, Ohtake A, Okazaki Y, Pujol R, RamirezMJ, Revah-Politi A, Shimura M, Stevens P, Taylor RW, Turner L, Williams H, Wilson C, Yigit G, Zahavich L, Alkuraya FS, Surralles J, Iglesias A, Mura-yama K, Wollnik B, Dattani M, Heath KE, Hickson ID, Jackson AP: Mutations in TOP3A Cause a Bloom Syndrome-like Disor-der. Am J Hum Genet, 2018; 103: 221-231. 14）Arai M, Yokoyama S, Watanabe C, Yoshida R,
Kita M, Okawa M, Sakurai A, Sekine M, Yotsumoto J, Nomura H, Akama Y, Inuzuka M, Nomizu T, Enomoto T, Nakamura S: Genetic and clinical characteristics in Japa-nese hereditary breast and ovarian cancer: first report after establishment of HBOC registration system in Japan. J Hum Genet, 2018; 63: 447-457.
15）Mikasa M, Kanai K, Li Y, Yoshino H, Mogushi K, Hayashida A, Ikeda A, Kawajiri S, Okuma Y, Kashihara K, Sato T, Kondo H, Funayama M, Nishioka K, Hattori N: COQ2 variants in Parkinsonʼs disease and multiple system atrophy. J Neural Transm (Vienna), 2018; 125: 937-944.
16）Mitsui Y, Yokoyama R, Fujimoto S, Kagemoto K, Kitamura S, Okamoto K, Muguruma N, Bando Y, Eguchi H, Okazaki Y, Ishida H, Takayama T: First report of an Asian family
with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) revealed with the germline mutation of the APC exon 1B promoter region. Gastric Cancer, 2018; 21: 1058-1063.
17）Nakajima C, Kamimoto K, Miyajima K, Matsumoto M, Okazaki Y, Kobayashi-Hattori K, Shimizu M, Yamane T, Oishi Y, Iwatsuki K: A Method for Identifying Mouse Pancreatic Ducts. Tissue Eng Part C Methods, 2018; 24: 480-485.
18）Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fuka-machi H, Yuasa Y, Tanaka S: Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models. Br J Cancer, 2018; 118: 972-984.
19）Shimada S, Mogushi K, Akiyama Y, Furu-yama T, Watanabe S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Tanabe M, Wands JR, Tanaka S: Comprehen-sive molecular and immunological character-ization of hepatocellular carcinoma. EBioMe-dicine, Epub 2018 Dec 29.
20）Urakami S, Inoshita N, Oka S, Miyama Y, Nomura S, Arai M, Sakaguchi K, Kurosawa K, Okaneya T: Clinicopathological characteris-tics of patients with upper urinary tract urothelial cancer with loss of immunohisto-chemical expression of the DNA mismatch repair proteins in universal screening. Int J Urol, 2018; 25: 151-156.
21）Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M, Kim Y, Tanabe Y, Takagi T, Hayashi T, Mogushi K, Kaneko K, Yao T, Saito T: KCTD12 is negatively regulated by Kit in gastrointesti-nal stromal tumors. Oncotarget, 2018; 9: 27016-27026.
22）Sunakawa Y, Mogushi K, LenzHJ, Zhang W, Tsuji A, Takahashi T, Denda T, Shimada K, Kochi M, Nakamura M, Kotaka M, Segawa Y, Tanioka H, Negoro Y, Moran M, Astrow SH, Hsiang J, Stephens C, Fujii M, Ichikawa W: Tumor Sidedness and Enriched Gene Groups for Efficacy of First-line Cetuximab Treat-ment in Metastatic Colorectal Cancer. Mol
Cancer Ther, 2018; 17: 2788-2795.
＊23）Tajima Y, Eguchi H, Chika N, Nagai T, Dechamethakun S, Kumamoto K, Tachikawa T, Akagi K, Tamaru JI, Seki H, Okazaki Y, Ishida H: Prevalence and molecular charac-teristics of defective mismatch repair epithe-lial ovarian cancer in a Japanese hospital-based population. Jpn J Clin Oncol, 2018; 48: 728-735.
24）Takao M, Yamaguchi T, Eguchi H, Tada Y, Kohda M, Koizumi K, Horiguchi SI, Okazaki Y, Ishida H: Characteristics of MUTYH variants in Japanese colorectal polyposis patients. Int J Clin Oncol, 2018; 23: 497-503. 25）Tanaka R, Masuda H, Fujimura S, Ito-Hirano
R, Arita K, Kakinuma Y, Hagiwara H, Kado M, Hayashi A, Mita T, Ogawa T, Watada H, Mizuno H, Sawada N, Asahara T: Quality-Quantity Control Culture Enhances Vasculo-genesis and Wound Healing Efficacy of Human Diabetic Peripheral Blood CD34+ Cells. Stem Cells Transl Med, 2018; 7: 428-438.
26）Yamaguchi S, Takahashi S, Mogushi K, Izumi Y, Nozaki Y, Nomizu T, Kakugawa Y, Ishida T, Ohuchi N, Ishioka C, Kato S: Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer. Oncotarget, 2018; 9: 14193-14206. 27）Ng YS, Lax NZ, Maddison P, Alston CL,
Blakely EL, Hepplewhite PD, Riordan G, Meldau S, Chinnery PF, Pierre G, Chronopou-lou E, Du A, Hughes I, Morris AA, Kamakari S, Chrousos G, Rodenburg RJ, Saris CGJ, Feeney C, Hardy SA, Sakakibara T, Sudo A, Okazaki Y, Murayama K, Mundy H, Hanna MG, Ohtake A, Schaefer AM, Champion MP, Turnbull DM, Taylor RW, Pitceathly RDS, McFarland R, Gorman GS: MT-ND5 Muta-tion Exhibits Highly Variable Neurological Manifestations at Low Mutant Load. EBio-Medicine, 2018; 30: 86-93.
28）Yoshino H, Nishioka K, Li Y, Oji Y, Oyama G, Hatano T, Machida Y, Shimo Y, Hayashida A, Ikeda A, Mogushi K, Shibagaki Y, Hosaka A, Iwanaga H, Fujitake J, Ohi T, Miyazaki D, Sekijima Y, Oki M, Kusaka H, Fujimoto KI, Ugawa Y, Funayama M, Hattori N: GCH1 mutations in dopa-responsive dystonia and
Parkinsonʼs disease. J Neurol, 2018; 265: 1860-1870.
29）Imai-Okazaki A, Kishita Y, Kohda M, Yatsuka Y, Hirata T, Mizuno Y, Harashima H, Hirono K, Ichida F, Noguchi A, Yoshida M, Tokoro-dani C, Nishiuchi R, Takeda A, Nakaya A, Sakata Y, Murayama K, Ohtake A, Okazaki Y: Barth Syndrome: Different Approaches to Diagnosis. J Pediatr, 2018; 193: 256-260. Laboratory of Proteomics and Biomolecular Science 〈Original Articles〉
1）Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N: NDP52 interacts with mitochon-drial RNA poly(A) polymerase to promote mitophagy. EMBO Rep, 2018; 19: e46363. 2）Sekihara K, Saitoh K, Yang H, Kawashima H,
Kazuno S, Kikkawa M, Arai H, Miida T, Hayashi N, Niyonsaba F, Sasai K, Tabe Y: Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratino-cytes and U937 cell lines. PLoS One, 2018; 13: e0199117.
3）Akaike K, Suehara Y, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Kurihara T, Kim Y, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T: PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/ FOXO1-positive alveolar rhabdomyosar-coma. Oncotarget, 2018; 9: 25206-25215. 4）Horimoto Y, Tanabe M, Kazuno S, Miura Y,
Mogushi K, Sonoue H, Arakawa A, Kajino K, Kobayashi T, Saito M: Elucidation of inhibi-tory effects on metastatic sentinel lymph nodes of breast cancer during One-Step Nucleic Acid Amplification. Sci Rep, 2018; 8: 7563.
＊ 5）Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T: IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewingʼs sarcoma. Oncotar-get, 2018; 9: 14428-14443.
6）Tabe Y, Saitoh K, Yang H, Sekihara K, Yamatani K, Ruvolo V, Taka H, Kaga N,
Kikkawa M, Arai H, Miida T, Andreeff M, Spagnuolo PA, Konopleva M: Inhibition of FAO in AML co-cultured with BM adipo-cytes: mechanisms of survival and chemo-sensitization to cytarabine. Sci Rep, 2018; 8: 16837.
7）Shoji H, Taka H, Kaga N, Ikeda N, Hisata K, Miura Y, Shimizu T: Choline-related metabo-lites influenced by feeding patterns in pre-term and pre-term infants. J Matern Fetal Neonatal Med, Epub 2018 Jul 22.
＊ 8）Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N: Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease. Neu-rology, 2018; 90: e404-e411.
9）Ishii M, Suehara Y, Sano K, Kohsaka S, Hayashi T, Kazuno S, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T: Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma. Oncotarget, 2018; 9: 37509-37519.
10）Asao R, Seki T, Takagi M, Yamada H, Kodama F, Hosoe-Nagai Y, Tanaka E, Trejo JAO, Yamamoto-Nonaka K, Sasaki Y, Hidaka T, Ueno T, Yanagita M, Suzuki Y, Tomino Y, Asanuma K: Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis. Sci Rep, 2018; 8: 5061.
11）Nitta A, Hori K, Tanida I, Igarashi A, Deyama Y, Ueno T, Kominami E, Sugai M, Aoki K: Blocking LC3 lipidation and ATG12 conjuga-tion reacconjuga-tions by ATG7 mutant protein containing C572S. Biochem Biophys Res Commun, Epub 2018 Nov 30.
Laboratory of Cell Biology 〈Original Articles〉
1）Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K: Increased diversity with reduced “diversity evenness”of tumor infiltrating T-cells for the successful cancer immunother-apy. Sci Rep, 2018; 8: 1058.
2）Takeda K, Nagamatsu K, Okumura K: A
water-soluble derivative of propolis aug-ments the cytotoxic activity of natural killer cells. J Ethnopharmacol, 2018; 218: 51-58. 3）Roman Aguilera A, Lutzky VP, Mittal D, Li
XY, Stannard K, Takeda K, Bernhardt G, Teng MWL, Dougall WC, Smyth MJ: CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity. Oncoimmunology, 2018; 7: e1424677.
4）Takeda K, Kitaura K, Suzuki R, Owada Y, Muto S, Okabe N, Hasegawa T, Osugi J, Hoshino M, Tsunoda T, Okumura K, Suzuki H: Quantitative T cell repertoire analysis of peripheral blood mononuclear cells from lung cancer patients following long-term cancer peptide vaccination. Cancer Immunol Immun-other, 2018; 67: 949-964.
5）Li XY, Das I, Lepletier A, Addala V, Bald T, Stannard K, Barkauskas D, Liu J, Aguilera AR, Takeda K, Braun M, Nakamura K, Jacquelin S, Lane SW, Teng MW, Dougall WC, Smyth MJ: CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms. J Clin Invest, 2018; 128: 2613-2625.
6）Harjunpää H, Blake SJ, Ahern E, Allen S, Liu J, Yan J, Lutzky V, Takeda K, Aguilera AR, Guillerey C, Mittal D, Li XY, Dougall WC, Smyth MJ, Teng MWL: Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromis-ing immune homeostasis. Oncoimmunology, 2018; 7: e1445949.
7）Yan J, Allen S, Vijayan D, Li XY, Harjunpää H, Takeda K, Liu J, Cua DJ, Smyth MJ, Teng MWL: Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23. Cancer Immu-nol Res, 2018; 6: 978-987.
8）Sakaguchi K, Koyanagi A, Kamachi F, Harauma A, Chiba A, Hisata K, Moriguchi T, Shimizu T, Miyake S: Breast-feeding regu-lates immune system development via trans-forming growth factor-β in mice pups. Pediatr Int, 2018; 60: 224-231.
9）Hirano T, Koyanagi A, Kotoshiba K, Shinkai Y, Kasai M, Ando T, Kaitani A, Okumura K, Kitaura J: The Fab fragment of anti-IgE Cε2
domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells. Sci Rep, 2018; 8: 14237.
10）Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsu-kawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H: The CD300e molecule in mice is an immune-acti-vating receptor. J Biol Chem, 2018; 293: 3793-3805.
〈Reviews〉
1）Mojic M, Takeda K, Hayakawa Y: The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion. Int J Mol Sci, 2018; 19: 89. Laboratory of Morphology and Image Analysis 〈Original Articles〉
1）Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N: NDP52 interacts with mitochon-drial RNA poly(A) polymerase to promote mitophagy. EMBO Rep, 2018; 19: e46363. ＊ 2）Yamaguchi J, Suzuki C, Nanao T, Kakuta S,
Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y: Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis. Autophagy, 2018; 14: 764-777. 3）Fujiwara N, Miyahara K, Nakazawa-Tanaka
N, Akazawa C, Yamataka A: Increased expression of Semaphorin 3A in the endothe-lin receptor-B null mouse model of Hirsch-sprung disease. J Pediatr Surg, 2018; 53: 326-329.
4）Nakazawa-Tanaka N, Fujiwara N, Miyahara K, Nakada S, Arikawa-Hirasawa E, Akazawa C, Urao M, Yamataka A: The effect of laminin-1 on enteric neural crest-derived cell migration in the Hirschsprungʼs disease mouse model. Pediatr Surg Int, 2018; 34: 143-147.
5）Fujiwara N, Nakazawa-Tanaka N, Miyahara K, Arikawa-Hirasawa E, Akazawa C, Yama-taka A: Altered expression of laminin alpha1 in aganglionic colon of endothelin receptor-B null mouse model of Hirschsprungʼs disease. Pediatr Surg Int, 2018; 34: 137-141.
Laboratory of Molecular and Biochemical Research 〈Original Articles〉
1）Kinjo T, Sun C, Ikeda T, Ikegami T, Tada Y, Akagi T, Yokota T, Koide H: Platelet-derived growth factor-C functions as a growth factor in mouse embryonic stem cells and human fibrosarcoma cells. Cell Mol Biol Lett, 2018; 23 (8).
2）Kadoguchi T, Shimada K, Koide H, Miyazaki T, Shiozawa T, Takahashi S, Aikawa T, Ouchi S, Kitamura K, Sugita Y, Hamad AS, Kuni-moto M, Sato-Okabayashi Y, Akita K, Isoda K, Daida H: Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice. Front Physiol, 2018; 9: 340.
Laboratory of Biomedical Research Resources 〈Original Articles〉
＊ 1）Nishioka I, Takai T, Maruyama N, Kamijo S, Suchiva P, Suzuki M, Kunimine S, Ochi H, Shimura S, Sudo K, Ogawa H, Okumura K, Ikeda S: Airway inflammation after epicuta-neous sensitization of mice requires protease activity of low-dose allergen inhalation. J Allergy Clin Immunol, 2018; 141: 2271-2273. e7.
2）Ohtake T, Kobayashi S, Mochida Y, Ishioka K, Moriya H, Hidaka S, Matsuura R, Sumida M, Katagiri D, Noiri E, Slavin S, Mizuno H, Tanaka R: Human peripheral blood mononu-clear cells incubated in vasculogenic condi-tioning medium dramatically improve ische-mia/reperfusion acute kidney injury in mice. Cell Transplantation, 2018; 27: 520-530. 3）Tanaka R, Masuda H, Fujimura S, Hirano-Ito
R, Arita K, Kakinuma Y, Hagiwara H, Kado M, Hayashi A, Mita T, Ogawa T, Watada H, Mizuno H, Sawada N, Asahara T: Quality-quantity control culture enhances vasculo-genesis and wound healing efficacy of dia-betic peripheral blood CD34+ cells. Stem Cells Transl Med, 2018; 7: 428-438.
＊ 4）Kado M, Tanaka R, Arita K, Okada K, Hirano R, Fujimura S, Mizuno H: Human peripheral blood mononuclear cells enriched in endothe-lial progenitor cells via quality and quantity controlled culture accelerate vascularization and wound healing in a porcine wound model.
Cell Transplant, 2018; 27: 1068-1079.
5）Hagiwara H, Higashibata A, Ogawa S, Kana-zawa S, Mizuno H, Tanaka R: Effectiveness of endothelial progenitor cell culture under microgravity for improved angiogenic poten-tial. Sci Rep, 2018; 8: 14239.
＊ 6）Sakaguchi K, Koyanagi A, Kamachi F, Harauma A, Chiba A, Hisata K, Moriguchi T, Shimizu T, Miyake S: Breast-feeding regu-lates immune system development via trans-forming growth factor-β in mice pups. Pediatr Int, 2018; 60: 224-231.
＊ 7）Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K: Biological effects of IL-26 on T cell-mediated skin inflammation including psoriasis. J Invest Dermatol, Epub 2018 Nov 10.
8）Okamoto T, Yamazaki H, Hatano R, Yamada T, Kaneko Y, Xu CW, Dang NH, Ohnuma K, Morimoto C: Targeting CD26 suppresses proliferation of malignant mesothelioma cell via downmodulation of ubiquitin-specific protease 22. Biochem Biophys Res Commun, 2018; 504: 491-498.
9）Ishimine M, Lee HC, Nakaoka H, Orita H, Kobayashi T, Mizuguchi K, Endo M, Inoue I, Sato K, Yokomizo T: The Relationship between TP53 Gene Status and Carboxyles-terase 2 Expression in Human Colorectal Cancer. Dis Markers, 2018; 2018: 5280736. 10）Ohba M, Saeki K, Koga T, Okuno T,
Kobayashi Y, Yokomizo T: Profiling of bioac-tive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method. Biochem Biophys Res Com-mun, 2018, 504: 562-568.
11）Sasaki F, Koga T, Ohba M, Saeki K, Okuno T, Ishikawa K, Nakama T, Nakao S, Yoshida S, Ishibashi T, Ahmadieh H, Kanavi MR, Hafezi-Moghadam A, Penninger JM, Sonoda KH, Yokomizo T: Leukotriene B4 promotes neo-vascularization and macrophage recruitment in murine wet-type AMD models. JCI Insight, 2018; 3: e96902.
＊12）Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, Murakami A, Matsuda A, Yokomizo T: Dietary ω-3 fatty acids alter the lipid
mediator profile and alleviate allergic con-junctivitis without modulating Th2 immune responses. FASEB J, Epub 2018 Nov 1. 13）Takasugi N, Araya R, Kamikubo Y,
Kane-shiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T: TMEM30A is a candidate interacting partner for the β-carboxyl-termi-nal fragment of amyloid-β precursor protein in endosomes. PLoS One, 2018; 13: e0200988. 14）Kamikubo Y, Yamana T, Hashimoto Y,
Sakurai T: Induction of Oxidative Stress and Cell Death in Neural Cells by Silica Nanopar-ticles. ACS Chem Neurosci, Epub 2018 Oct 5. 15）Kaneshiro N, Imaoka R, Komai M, Kashiyama
T, Sakurai T, Uehara T, Takasugi N: Func-tional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells. Biochem Biophys Res Com-mun, 2018; 501: 1023-1028.
＊16）Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsu-kawa T, Takahashi M, Yamanishi Y, Oki T, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: The CD300e molecule in mice is an immune-activating receptor. J Biol Chem, 2018; 293: 3793-3805.
17）Ohtsuji M, Lin Q, Okazaki H, Takahashi K, Amano H, Yagita H, Nishimura H, Hirose S: Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice. Arthritis Res Ther, 2018; 20: 25.
18）Tsukita Y, Okazaki T, Ebihara S, Komatsu R, Nihei M, Kobayashi M, Hirano T, Sugiura H, Tamada T, Tanaka N, Sato Y, Yagita H, Ichinose M: Beneficial effects of sunitinib on tumor microenvironment and immunother-apy targeting death receptor 5. Oncoimmu-nology, 2018; 8: e1543526.
19）Negishi N, Sato T, Yamashita-Kanemaru Y, Shibuya K, Uchida K, Kametani Y, Yagita H, Kitaura J, Okumura K, Habu S: CD155-trans-ducing signaling through TIGIT plays an important role in transmission of tolerant state and suppression capacity. Immunohori-zons, 2018; 2: 338-348.
〈Reviews〉
1）Chiba A, Murayama G, Miyake S: Mucosal-associated invariant T cells in autoimmune diseases. Front Immunol, 2018; 9: 1333. 2）Ohnuma K, Hatano R, Komiya E, Otsuka H,
Itoh T, Iwao N, Kaneko Y, Yamada T, Dang NH, Morimoto C: A novel role for CD26/ dipeptidyl peptidase IV as a therapeutic target. Front Biosci (Landmark Ed), 2018; 23: 1754-1779.
3）Lee HC, Yokomizo T: Applications of mass spectrometry-based targeted and non-targeted lipidomics. Biochem Biophys Res Commun, 2018; 504: 576-581.
4）Okuno T, Yokomizo T: Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2. Inflamm Regen, 2018, 38: 29.
5）Yokomizo T, Nakamura M, Shimizu T: Leu-kotriene receptors as potential therapeutic targets. J Clin Invest, 2018; 128: 2691-2701. 〈Books〉
1）Hatano R, Ohnuma K, Yamada T, Okamoto T, Komiya E, Otsuka H, Itoh T, Yamazaki H, Iwao N, Kaneko Y, Dang NH, Morimoto C: Chapter 1. The Use of the Humanized Anti-CD26 Monoclonal Antibody YS110 as a Novel Targeted Therapy for Refractory Cancers and Immune Disorders. In: Berhardt LV, ed. Advances in Medicine and Biology. NY: Nova Science Publishers, Inc, 2018; 129: 1-44. Laboratory of Genome Research
〈Original Articles〉
1）Isoda K, Akita K, Kitamura K, Sato-Okabayashi Y, Kadoguchi T, Isobe S, Ohtomo F, Sano M, Shimada K, Iwakura Y, Daida H: Inhibition of interleukin-1 suppresses angio-tensin II-induced aortic inflammation and aneurysm formation. Int J Cardiol, 2018; 270: 221-227.
2）Kadoguchi T, Shimada K, Koide H, Miyazaki T, Shiozawa T, Takahashi S, Aikawa T, Ouchi S, Kitamura K, Sugita Y, Hamad AS, Kuni-moto M, Sato-Okabayashi Y, Akita K, Isoda K, Daida H: Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice. Front Physiol, 2018; 9: 340.
3）Sato S, Uchihara T, Fukuda T, Noda S, Kondo
H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N: Loss of autophagy in dopami-nergic neurons causes Lewypathology and motor dysfunction in aged mice. Sci Rep, 2018; 8: 2813.
4）Sato S, Hattori N: Dopaminergic Neuron-Specific Autophgy-Deficient Mice. Methods Mol Biol, 2018; 1759: 173-175.
＊ 5）Okuzumi A, Kurosawa M, Hatano T, Taka-nashi M, Nojiri S, Fukuhara T, Yamanaka T, Miyazaki H, Yoshinaga S, Furukawa Y, Shimogori T, Hattori N, Nukina N: Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment. Acta Neuropathol Commun, 2018; 6: 96.
6）Osonoi Y, Mita T, Azuma K, Nakajima K, Masuyama A, Goto H, Nishida Y, Miyatsuka T, Fujitani Y, Koike M, Mitsumata M, Watada H: Defective autophagy in vascular smooth muscle cells enhances cell death and athero-sclerosis. Autophagy, 2018; 14: 1991-2006. 7）Kamitani M, Miyatsuka T, Miura M, Azuma
K, Suzuki L, Himuro M, Katahira T, Nishida Y, Fujitani Y, Watada H: Heterogeneity of autophagic status in pancreatic β cells under metabolic stress. Biochem Biophys Res Com-mun, 2018; 496: 328-334.
8）Masuyama A, Mita T, Azuma K, Osonoi Y, Nakajima K, Goto H, Nishida Y, Miyatsuka T, Mitsumata M, Watada H: Defective autoph-agy in vascular smooth muscle cells enhances atherosclerotic plaque instability. Biochem Biophys Res Commun, 2018; 505: 1141-1147. 9）Miura M, Miyatsuka T, Katahira T, Sasaki S,
Suzuki L, Himuro M, Nishida Y, Fujitani Y, Matsuoka TA, Watada H: Suppression of STAT3 signaling promotes cellular reprog-ramming into insulin-producing cells induced by defined transcription factors. EBioMedi-cine, 2018; 36: 358-366.
10）Honda A, Komiya K, Hara A, Fukunaka A, Suzuki L, Miyatsuka T, Ogihara T, Fujitani Y, Watada H: Normal pancreatic β-cell function in mice with Rip-Cre-mediated inactivation of p62/SQSTM1. Endocr J, 2018; 65: 83-89. 11）Uesato T, Ogihara T, Hara A, Iida H,
Miyatsuka T, Fujitani Y, Takeda S, Watada H: Enhanced Expression of the Key Mitosis
Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice. J Endocr Soc, 2018; 2: 207-219.
12）Okazaki M, Horimoto Y, Tanabe M, Ichikawa Y, Tokuda E, Arakawa A, Kobayashi T, Saito M: Predictive markers for efficacy of everoli-mus plus exemestane in patients with luminal HER2-nagative metastatic breast cancer. Med Oncol, 2018; 35: 48.
13）Lin Q, Ohtsuji M, Amano H, Tsurui H, Tada N, Sato R, Fukuyama H, Nishimura H, Verbeek JS, Hisose S: FcγRIIB on B cells and myeloid cells modulates B cell activation and autoantibody responses via different but synergistic pathways in Lupus-Prone Yaa mice. J Immunol, 2018; 201: 3199-3210. 14）Asada Y, Okano M, Ishida W, Iwamoto S,
Fukuda K, Hirakata T, Tada N, Fukushima A, Ebihara N, Kudo A, Matsuda A: Periostin deletion suppresses late-phase response in mouse experimental allergic conjunctions. Allergol Int, Epub 2018 Nov 9.
Division of Foreign Languages, Department of General Education
〈Original Articles〉
1）Kuramoto N, Koizumi R: Current issues in large-scale educational assessment in Japan: Focus on national assessment of academic ability and university entrance examinations. Assess Educ, 2018; 25: 415-433.
2）Nealy M, Takeda Y: Using Photography to Improve Attitudes Towards English Practice and Foster Habits of Mind. Medical Educa-tion, 2018; 49: 347-352.
〈Books〉
1）Asano K: Chapter Three: An Analysis of Word Repetition in L2 ELLsʼ English Essays. In: Can C, Patsala P, Tatsioka Z, eds. Lan-guage in Focus: Contemporary Means and Methods in ELT and Applied Linguistics. Estonia: LIF - Language in Focus, 2018; 33-50.
Division of Physics, Department of General Educa-tion
〈Original Articles〉
1）Whittier RF, Hatsuda M: Problem-Based Learning to Encourage Active Learning and
Teamwork Among First Year Medical Stu-dents - Student Reports -. Juntendo Medical Journal, 2018; 64: 96-97.
2）Tanaka K: Operator relations for gravita-tional form factors of a spin-0 hadron. Physical Review, 2018; D98: 034009-1~034009-11. 3）Hatta Y, Rajan A, Tanaka K: Quark and
gluon contributions to the QCD trace anom-aly. Journal of High Energy Physics, 2018; 1812: 008-1~008-18.
〈Reviews〉
1）Brambilla N, Fulsom B, Hanhart C, Kiyo Y, Mizuk R, Mussa R, Polosa A, Prelovsek S, Shen C, Godfrey S, Guo F, Moats K, Nefediev A, Olsen S, Pakhlov P, Tamponi U, Vairo A: Quarkonium (like) Physics. The Belle II Physics Book, 2018: 431-498.
Division of Chemistery, Department of General Education
〈Original Articles〉
1）Uchiyama S, Sasaki T, Ishihara R, Fujiwara K, Sugo T, Umeno D, Saito K: High-resolution separation of neodymium and dysprosium ions utilizeing extractant-impregnated graft-type particles. J Chromatogr A, 2018; 1533: 10-16.
2）Komatsu S, Ikedo Y, Asoh TA, Ishihara R, Kikuchi A: Fabrication of Hybrid Capsules via CaCO3 Crystalization on Degradable Coacervate Droplets. Langmuir, 2018; 34: 3981-3986.
3）Asai S, Hanzawa Y, Konda M, Suzuki D, Magara M, Kimura T, Ishihara R, Saito K, Yamada S, Hirota H: Rapid separation of zirconium using microvolume anion-exchange cartridge for 93Zr determination with isotope dilution ICP-MS, Talanta, 2018; 185: 98-105.
4）Komatsu S, Kayano H, Ando Y, Asho T, Ishihara R, Kikuchi A: Preparation of thermo- and redox-responsive branched polymers composed of three-armed oligo (ethylene glycol). J Polym Sci A, 2018; 56: 2623-2629.
5）Hiraishi Y, Yamaguchi S, Yoshizaki T, Nambu A, Shimura E, Takamori A, Narushima S, Nakanishi W, Asada Y, Numata T, Suzukawa M, Yamauchi Y, Matsuda A, Arae K, Morita
H, Hoshino T, Suto H, Okumura K, Matsu-moto K, Saito H, Sudo K, Iikura M, Nagase T, Nakae S: IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation. Sci Rep, 2018; 8: 18052.
6）Yamaguchi S, Nambu A, Numata T, Yoshi-zaki T, Narushima S, Shimura E, Hiraishi Y, Arae K, Morita H, Matsumoto K, Hisatome I, Sudo K, Nakae S: The roles of IL-17C in T cell-dependent and -independent inflamma-tory diseases. Sci Rep, 2018; 8: 15750. 7）Numata T, Yoshizaki T, Yamaguchi S,
Shimura E, Iwakura Y, Harada K, Sudo K, Tsuboi R, Nakae S: IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitiv-ity. Biochem Biophys Res Commun, 2018; 506: 429-436.
8）Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S: IL-25 enhances TH17 cell-mediated contact derma-titis by promoting IL-1β production by dermal dendritic cells. J Allergy Clin Immu-nol, 2018; 142: 1500-1509.e10.
Division of Glycobiologics 〈Original Articles〉
1）Higashi N, Waki M, Sudo Y, Suzuki S, Oku T, Tsuiji M, Tsuji T, Miyagishi M, Takahashi K, Nakajima M, Irimura T: Incorporation, intra-cellular trafficking and processing of extracel-lular heparanase by mast cells: Involvement of syndecan-4-dependent pathway. Biochem Biophys Res Commun, 2018; 503: 3235-3241. 2）Adachi H, Nakae K, Sakamoto S, Nosaka C,
Atsumi S, Shibuya M, Higashi N, Nakajima M, Irimura T, Nishimura Y: Corrigendum: Microbial metabolites and derivatives tar-geted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. J Antibiot (Tokyo), 2018; 71: 349.
3）Fujihira H, Usami K, Matsuno K, Takeuchi H, Denda-Nagai K, Furukawa JI, Shinohara Y, Takada A, Kawaoka Y, Irimura T: A critical domain of ebolavirus envelope glycoprotein determines glycoform and infectivity. Sci Rep, 2018; 8: 5495.
4）Yang K, Huang R, Fujihira H, Suzuki T, Yan N: N-glycanase NGLY1 regulates mitochon-drial homeostasis and inflammation through NRF1. J Exp Med, 2018; 215: 2600-2616.
