Acta Medica Okayama
Volume 49, Issue 4 1995 Article 2
A UGUST 1995
Effect of vasopressin V1- and V2-receptor stimulation on blood pressure in DOCA-salt
hypertensive rats.
Yukari Mimura
∗Toshio Ogura
†Takayoshi Yamauchi
‡Fumio Otsuka
∗∗Tetsuya Oishi
††Kazushi Harada
‡‡Masami Hashimoto
§Zensuke Ota
¶∗Okayama University,
†Okayama University,
‡Okayama University,
∗∗Okayama University,
††Okayama University,
‡‡Okayama University,
§Okayama University,
¶Okayama University,
Copyright c1999 OKAYAMA UNIVERSITY MEDICAL SCHOOL. All rights reserved.
Effect of vasopressin V1- and V2-receptor stimulation on blood pressure in DOCA-salt
hypertensive rats. ∗
Yukari Mimura, Toshio Ogura, Takayoshi Yamauchi, Fumio Otsuka, Tetsuya Oishi, Kazushi Harada, Masami Hashimoto, and Zensuke Ota
Abstract
We recently reported that stimulation of the arginine vasopressin (AVP) V1-receptor enhanced the pressor response in spontaneously hypertensive rats (SHR). In the present study, we investi- gated acute changes in systolic blood pressure (SBP) and heart rate (HR) after intravenous injec- tions of AVP, OPC-21268 (a V1-receptor antagonist), and OPC-31260 (a V2-receptor antagonist), in anesthetized DOCA-salt hypertensive rats (DOCA) and age-matched sham-operated Wistar rats (control) to determine whether the pressor effect is specific to SHR or is present in other hyper- tensive animal models. SBP increased significantly in DOCA rats 9 min after injection of AVP 5 ng/kg without a concomitant increase in HR. Neither OPC-21268 3mg/kg nor OPC-31260 3mg/kg caused significant changes in SBP or HR. SBP tended to increase when AVP was administered af- ter injection of OPC-31260. HR increased significantly 15 min after the combined treatment with OPC-31260 and AVP in DOCA rats compared with control rats. SBP did not change significantly when AVP was administered after injection of OPC-21268 in DOCA or control rats, but HR de- creased significantly from 1 to 4 min after injection of AVP in DOCA rats. Our results suggest that V1-receptor stimulation does not enhance the pressor response in the DOCA rat, which is a model of volume-dependent hypertension, suggesting that the AVP system, especially V1-receptor, is not as important in the development or maintenance of hypertension in DOCA rats as in SHR.
KEYWORDS:vasopressin, DOCA-salt hypertensive rat, V1-and V2-receptor antagonist, spon- taneously hypertesive rat(SHR), OPC-21268
∗PMID: 7502678 [PubMed - indexed for MEDLINE]
Copyright (C) OKAYAMA UNIVERSITY MEDICAL SCHOOL
1 Mimura et al.: Effect of vasopressin V1- and V2-receptor stimulation on blood
Produced by The Berkeley Electronic Press, 1995
2 Acta Medica Okayama, Vol. 49 [1995], Iss. 4, Art. 2
http://escholarship.lib.okayama-u.ac.jp/amo/vol49/iss4/2
3 Mimura et al.: Effect of vasopressin V1- and V2-receptor stimulation on blood
Produced by The Berkeley Electronic Press, 1995
4 Acta Medica Okayama, Vol. 49 [1995], Iss. 4, Art. 2
http://escholarship.lib.okayama-u.ac.jp/amo/vol49/iss4/2
5 Mimura et al.: Effect of vasopressin V1- and V2-receptor stimulation on blood
Produced by The Berkeley Electronic Press, 1995
6 Acta Medica Okayama, Vol. 49 [1995], Iss. 4, Art. 2
http://escholarship.lib.okayama-u.ac.jp/amo/vol49/iss4/2
7 Mimura et al.: Effect of vasopressin V1- and V2-receptor stimulation on blood
Produced by The Berkeley Electronic Press, 1995
8 Acta Medica Okayama, Vol. 49 [1995], Iss. 4, Art. 2
http://escholarship.lib.okayama-u.ac.jp/amo/vol49/iss4/2
