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Clin Case Rep. 2021;9:e04583.

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https://doi.org/10.1002/ccr3.4583 wileyonlinelibrary.com/journal/ccr3

A previously healthy 42- year- old man was admitted to our hospital with a complaint of abdominal pain for a day. The patient's vital signs were within normal range, and he had no physical findings other than tenderness in the upper right abdomen. Blood analysis showed elevations of C- reactive protein (5.4  mg/dl). Computed tomography revealed high density in the appendix (Figure 1), and the patient was di- agnosed with appendicitis. Subsequent interviews revealed that the patient was taking barium for a medical examination 3 days before his visit. The patient underwent antibiotic treat- ment for barium appendicitis. The patient had no peritoneal irritation symptoms and responded only to medical therapy.

Barium remains in the appendix for more than 72  h in only 8% of patients,1 and in a small number of these patients, the remaining barium obstructs the lumen of the appendix and causes appendicitis. The prognosis and treatment of patients with barium appendicitis are not par- ticularly different from those of patients with non- barium appendicitis. However, the frequency of appendiceal perfo- ration in barium appendicitis was reported to be higher (not significantly) than that in non- barium appendicitis.2 Since barium is widely used in gastric cancer screening in Japan, the diagnosis and recognition of barium appendicitis are particularly valuable.

Received: 12 April 2021

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Revised: 11 June 2021

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Accepted: 21 June 2021 DOI: 10.1002/ccr3.4583

C L I N I C A L I M A G E

Barium appendicitis

Daisuke Omura

1,2

| Naoko Yunoki

2

| Yuki Otsuka

1

| Yasuhiro Nakano

1

|

Hideharu Hagiya

1

| Fumio Otsuka

1

This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

© 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

1Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan

2Department of Internal Medicine, Akaiwa Medical Association Hospital, Akaiwa, Japan

Correspondence

Daisuke Omura, Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2- 5- 1 Shikata- cho, Kita- ku, Okayama 700- 8558, Japan.

Email: [email protected] Funding information

None

Abstract

We have presented a case of barium appendicitis, which is a rare complication of barium enema studies. Barium sulfate is used widely for gastrointestinal radiographic studies and is associated with few complications. Clinicians need to be fully aware of this complication.

K E Y W O R D S appendicitis, barium

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OMURA etAl.

ACKNOWLEDGEMENTS None to report.

CONFLICT OF INTEREST None declared.

AUTHOR CONTRIBUTIONS

DO wrote the first draft and managed all of the submission process. NY, YO, and YN supervised clinical management of the patient. HH and FO contributed to clinical manage- ment of the patient and revised the manuscript.

ETHICAL APPROVAL

Informed consent was obtained from the patient to publish this case report.

DATA AVAILABILITY STATEMENT Not applicable.

ORCID

Daisuke Omura  https://orcid.org/0000-0002-7878-3813 Yuki Otsuka  https://orcid.org/0000-0001-6015-6128 Hideharu Hagiya  https://orcid.org/0000-0002-5086-1891 Fumio Otsuka  https://orcid.org/0000-0001-7014-9095 REFERENCES

1. Fang Y- J, Wang H- P, Ho C- M, Liu K- L. Barium appendicitis.

Surgery. 2009;146(5):957- 958.

2. Katagiri H, Lefor AK, Kubota T, Mizokami K. Barium appendici- tis: a single institution review in Japan. World J Gastrointest Surg.

2016;8(9):651- 655.

How to cite this article: Omura D, Yunoki N, Otsuka Y, Nakano Y, Hagiya H, Otsuka F. Barium

appendicitis. Clin Case Rep. 2021;9:e04583. https://

doi.org/10.1002/ccr3.4583

FIGURE 1 Abdominal computed tomography

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