肺炎・肺傷害急性期および修復期における骨髄由来
細胞の重要性とその制御に関する研究
著者
久保 裕司
肺炎･肺傷害急性期および修復卿こおけ鼻骨髄
由来細胞の重要性とその制御に関する研究
課題番号: 13670589
平成13年度∼平成14年度科学研究費補助金(基盤研究(C)(7))
研究成果報告書
平成1･与年12月
研究代表者:久保裕司
(東北大学医学部附属病院 老年･呼吸器内科的4)
はしがき
研究組織
研究代表者:久保裕司(東北大学医学部附属病院抑j)
交付決定額(配分額) (金額単位:千円)
直接経費 亊I
ｨﾆ
N
合計
平成13年度 ﾃC 0 ﾃC 平成14年度 ﾃ# 0 ﾃ# 総計 ﾃc 0 ﾃc研究発表
(1)学会誌等
1･ Yamada M, Kubo H, Kobayashi S, Ishizawa K, Numasaki M, Ueda S, Suzuki T,
Sasaki H･ Bone marrow-derived progenitor cellsare important for lung repalr after LPS-induced lung lnJury･ J･ Immunology 172: 1 266-1272, 2004.
2･ Ishizawa K, Kubo IもYamada M, Kobayashi S, Numasaki M, Ueda S, Suzuki T, Sasaki H･ Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema･ FEES Letter 556 : 249-252, 2004.
3･ Song C, Suzuki S, Kubo H, ChidaM, Hoshikawa Y, TabataT, Kondo T. Effects
of antiplatelet agents on pulmonary haemodynamic response to fMLP in endotoxin primed rats. Thorax 59:39-44, 2(氾4.
4･ HiraiH,基地旦且Yamaya M, Nakayama K, Numasaki M, Kobayashi S, Suzuki S,
Shibahara S, Sasaki H･ Microsatellite polymo叩hism in heme oxygenase-1 gene
promoter is associated wi也 susceptibility to oxidant-induced apoptosis in
lymphoblastoid cell lines. Blood 102: 16 1911621 , 2(氾3.
5･ Tsubochi H･ Suzuki S, Kubo H, Ueno T, Yoshimura T, Suzuki T, Sasano H,
Endotoxin lnstillation in Rats. Am J Respir Crit Care Med･ 167: 205-210, 20031
6. Ishida I, Kubo H, Suzuki S, Suzuki T, Akashi S, Imoue K, Maeda S, Kikuchi H, sasaki H, Rondo T･ Hypoxia diminishes Tわll-like receptor 4 expression through
ROS generated by mitochondria in endothelial cells･ J･ Immunology 169:
2069-2075, 2002.
7. Noda M, Suzuki S, Tsubochi H, Sugita M, Maeda S, Kobayashi S, Kubo H･
Kondo T. Single Dexamethasone Injection Increases AIveolarFIuid Clearance in
Adult Rats. Critical Cue Medicine. 31: 1 183-1 189, 2003.
8. Suzuki S, Koyama K, Damel A, Ishibashi H, Kobayashi S･ Kubo H, Suzuki T･
sasano H, Krozowski ZS. Dexamethasone Upregulates lib-Hydroxysteroid
Dehydrogenase Type2 in BEAS-2B Cells･ Am J Respir CriE Cue Med･ 167:
1244- 1249, 2003.
9. Inoue K, Suzuki S, Kubo H, Ishida I, Ueda S, Kondo T. Effects ofrewarmlng On
nuclearfactor-kappaB and interleukin-8 expression in cold-preservedalveolar
epithelial cells･ Transplantation･ 76: 409415, 2003･
10. OhmiT, Kubo H, Sasaki H. Care for the Older People･ Int･ Med･ 42: 932-940,
2(X)3.
1 I. Moriyama K, Ishizaka A, Nakamura M, Kubo H･ Kotani T･ Yamamoto S, Takagi NE, Kajikawa 0, Frevert CW, Kotake Y, Morisaki H, Koh H, Tasaka S, Martin
TR, Takeda J. Enhancement of the Endotoxin Recognition Pathway by Ventilation with a LargeTidal Volume in Rabbits･ American Joumal of Physiology: Lung Cellular and Molecular Physiology (in press)･
(2)口頭発表
国際学会
1. Kubo H, Yamada M, Kobayashi S, Ishizawa K, M･ Nemoto･ MI Numazaki･ S･
Ueda, Sasaki H. Bone Marrow Derived Progenitor Cells Are Important for Lung
A620, 2003.
2. Yamada M, Kubo H, Kobayashi S, Takahashi H, Ishizawa K, Sasaki H･ IFNg
Contributes to Hyperoxia-Induced Lung Injury in Mice. Am J RespE-r Crit Care
Med. 167: A621, 2003.
3. Ishizawa K, Kubo H, Takahashi K, Samuson MJ, Kobayashi S, Yamada M,
Yamaya M, Sasaki H. Erythromycin Increase Tわll-Like Receptor 2 Expression on
Human Dendritic Cell. Am J Respir Crit Care Med. 167: A590, 2003.
4. Hirai H, Kubo H, Nakayama K, Yamaya M, Sasaki HI Microsatellite
Polymorphism in Heme Oxygenase-1 Gene Promoter Is Associated with
Susceptibilityto Oxidant-Induced Apoptosis in Lymphoblastoid Cell Lines･ Am J
Respir Crit Cue Med. 167: A66, 2(氾3.
5. Kobayashi S, Kubo H, Akashi S, Guo LY, YanaiM, Shinkawa M, Yamaya M,
Sasaki H. Endotoxin-Induced Cell Activation, Resulting NF-kB Activation
through Toll-Like Receptor 41MD12 Complex, Is Inhibited by Bilirubin･ Am J
Respir Crit Care Med. 167: A731, 2(氾3.
6. Kubo H, Kobayashi S, Okazaki T, Suzuki T, Ishida I, Maeda S, Sasaki H. IFN
Gamma Contributes To Hyperoxia-Induced Toll-Like Receptor 4 Upregulation In Murine Lungs. Am J Respir Crit Care Med. 165: A76, 2002･
7. Kobayashi S, Kubo H, Ishida I, Suzuki T, Okazaki T, Sasaki H. TblトLike
Receptor 4 May Contribute To Hyperoxia-Induced Lung Injury･ Am J Respir Crit
Cwe Med. 165: A76, 2(氾2.
8. Inoue K, Suzuki S, Kubo H, Ueda S, Rondo T. Rho ls Involved ln The Signaling
Pathway Of The Cold瓜ewamlng Induced IL8 Release From Alveolar Epithelial
Cells. Am J Respir Crit Cane Med. 165: A76, 20021
9. Okazaki T, Nakao A, Kubo H, Yamaya M, Takahashi F, Thkahashi K, Yagita H,
Okumura K, Sasaki H. Impalment Of Bleomycin-Induced Lung Fibrosis ln CD28-Deficient Mice. Am J Respir Crit Cue Med. 1 65: A76, 2002･
Sasaki H. Heparanase Expression Could Be a Biological Prognostic Indicator in
Postoperative Non-Small Cell Lung Carcinoma. Am J Respir Crit Care Med･ 1 67:
A517, 2(刀3.
