Clarification of individual-to-genic biological effects of alternating current-high magnetic fields with newly developed magnetic field generators

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生物学的作用解析用高磁場発生装置の開発と個体:

遺伝子レベルでの磁場効果解明

著者山本博

著者別表示 Yamamoto Hiroshi

雑誌名平成9(1997)年度科学研究費補助金基盤研究(A) 研究成果報告書概要

巻 1995 1997

ページ 10p.

発行年 1999‑03‑15

URL http://doi.org/10.24517/00066217

Creative Commons : 表示 ‑ 非営利 ‑ 改変禁止 http://creativecommons.org/licenses/by‑nc‑nd/3.0/deed.ja

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1997 Fiscal Year Final Research Report Summary

Clarification of individual-to-genic biological effects of alternating current-high magnetic fields with newly developed magnetic field generators

Research Project

Project/Area Number

07558203

Research Category

Grant-in-Aid for Scientiﬁc Research (A)

Allocation Type

Single-year Grants

Section

展開研究

Research Field

環境影響評価(含放射線⽣物学)

Research Institution

KANAZAWA UNIVERSITY

Principal Investigator

YAMAMOTO Hiroshi Kanazawa Univ., Sch.Med., Dept.Biochem.Professor and Chairman, 医学部, 教授 (00115198)

Co-Investigator(Kenkyū-buntansha)

HOSONO Ryuji Kanazawa Univ., Sch.Health Sci., Dept.Bioinformatics Professor, 医学部, 教授 (40019617)

YAMADA Sotoshi Kanazawa Univ., Faculty Tech., Lab.Mag.Field Contr.Appl., Visiting Professor, ⼯学部, 教授 (80019786) TANIMOTO Yoshifumi Hiroshima Univ., Faculty Sci., Dept.Chem.Professor, 理学部, 教授 (10110743)

YONEKURA Hideto Kanazawa Univ., Sch.Med., Dept.Biochem.Associate Professor, 医学部, 助教授 (80240373)

Project Period (FY)

1995 – 1997

Search Research Projects How to Use

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Research Products

(160 results)

All Other All Publications (160 results)

Keywords

high magnetic ﬁelds / Caenorhabditis elegans / DNA synthesis / mismatch repair / transcription / heat shock

Research Abstract

Recent advances in electrotechnology have given rise to previously unexperienced environments, in which strong magnetic fields are encountered. To test their effects on biological processes, we developed equipment by which alternating-current high magnetic stimuli can be administered with the physiological temperature being kept constant. Experiments with a simple multicellular organism, the nematode Caenorhabditis elegans, revealed that an exposure to a 1.7 T peak flux density modestly inhibited the animal's growth as well as reproduction, and caused transient derangement in its locomotor behavior. However, all of these phenotypic changes were reversible. Neither lethal nor mutagenic effects were noticed. The life span was not affected by the magnetic exposure. Next, DNA polymerase-catalyzed DNA synthesis, mutS-dependent DNA mismatch repair and RNA polymerase-catalyzed RNA transcription were conducted in vitro in the presence or absence of magnetic exposure. Neither the rates and fidelities of DNA and RNA syntheses nor the efficiency of DNA repair were affected by high magnetic fields. The results suggest that the living organism and the basic genic reactions would seem to be relatively resistant to, or to well compensate for, the high magnetic fields. In a transgenic nematode, however, a heat-shock promoter was found to be inducible by the exposure to high magnetic fields, this indicating that magnetic stimuli could offer a stress to the living organism.

[Publications] Kazuo Bessho: "Biological responses in Caenorhabditis elegans to high magnetic ﬁelds" EXPERIENTIA. 51. 284-288 (1995) 

[Publications] Motohiro Nomura: "Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-lnduced

Proliferation of Endothelial Cells and Pericytes." J. Biol. Chem.270. 28316-28324 (1995) 

[Publications] Sho-ichi Yamagishi: "Receptor-Mediated Toxicity to Pericytes of Advanced Glycosylation End Products:" Biochem. Biophys. Res.

Commun.213. 681-687 (1995) 

[Publications] Hitomi Takanaga: "cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter." Biochem. Biophys. Res.

Commun.217. 370-377 (1995) 

[Publications] Emi Nakashima: "Reversal of Drug Sensitivity in MDR Subline of P388 Leukemia by Gene-Targeted Antisense Oligonucleotide." J.

Pharmaceutical Sciences. 84. 1205-1209 (1995) 

[Publications] Takeda Ryoyu: "Aldosterone biosynthesis and action in vascular cells." Steroids. 60. 120-124 (1995) 

[Publications] Masahide Kaji: "Antisense oligonucleotides against c-met mRNA inhibit the growth of human gastric cancer cells." Antisense Research

and Development. 5. 99-100 (1995) 

[Publications] ⾕本能⽂: "界⾯活性剤ミセル⽔溶液中の光化学反応と磁場効果" 表⾯. 33. 282-290 (1995) 

[Publications] ⾕本能⽂: "強磁場中の有機化学" 有機合成化学協会誌. 53. 413-422 (1995) 

[Publications] Sotoshi Yamada: "″Eﬀects of High AC Magnetic Field Stimulus to the Nematode″" ADVAMCED COMPUTATIONAL AND DESIGN

TECHNIQUES IN APPLIED ELECTROMAGNETIC SYSTEMS. 181-184 (1995) 

[Publications] Hong Cao: "Eﬀect of High Magnetic Field on the Decay Rate of Chain-Linked lllntramolecular Exciplex Fluorescence" Chemical Physics

Letters. 246. 171-175 (1995) 

[Publications] Masahide Kaji: "Participation of c-met in the progression of human gastric cancers ; anti-c-met oligonucleotides inhibit proliferation or

invasiveness of gastric cancer cells." Cancer Gene Therapy. 3. 393-404 (1996) 

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[Publications] Sho-ichi Yamagishi: "Advanced glycosylation end products stimulate the growth but inhibit the prostacyclln-producing ability of endothelial cells through interactions with their receptors." FEBS Letters. 384. 103-106 (1996)



[Publications] Yasuhiko Yamamoto: "Advanced glycation endproducts-receptor interactions stimulate the growth of human pancreatic cancer cells through the induction of platelet-derived growth factor-B" Biochem. Biophys. Res. Commun.222. 700-705 (1996) 

[Publications] Yutaka Yonemura: "Correlation between overexpression of c-met gene and the progression of gastric cancer." Int. J. Oncology. 8. 555-

560 (1996) 

[Publications] Hiroshi Yamamoto: "Vascular VEGF : The expression and roles in hypoxia-driven angiogenesis." Journal of Vascular Research. 33. 110

(1996) 

[Publications] Shoichi Yamagishi: "Advanced glycation endproducts can promote angiogenesis through autocrine vascular endothlial growth factors."

Journal of Vascular Research. 33. 110 (1996) 

[Publications] Yasuo Hirono: "Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer." British

Journal of Cancer. 74. 2003-2007 (1996) 

[Publications] Yonekura, H. , et al: "Identiﬁcation of the ﬁve essential histidine residues for peptidylglycine monooxygenase." Biochemical and

Biophysical Research Communication. 218. 495-499 (1996) 

[Publications] Y. Fujiwara: "Eﬀect of High Magnetic Fields on the Reverse Electron Transfer Process in an α-Cyclodextrin Inclusion Complex of

Phenothiazine-Viologen Chain-Linked Compound." Chem. Phys. Lett.259. 361-367 (1996) 

[Publications] Ronan, P.: "Eﬀect of low frequency magnetic ﬁelds and induced current on DNA digestion." Proc. of Australian University Power

Engineering Conference. 259-262 (1996) 

[Publications] ⼭⽥外史: "「低周波交流磁界による⽣体内化学反応への影響」" 電気学会論⽂誌. 116-C. 187-192 (1996) 

[Publications] Sotoshi Yamada: "Eﬀects of Low Frequency Magnetic Fields on DNA Synthesis." IEEE Trans. on Magnetics. 32. 5115-5117 (1996) 

[Publications] Nafalski, A.: "Measurement of magnetic ﬁelds in urban environment." Proc. of Australian University Power Engineering Conference.

247-252 (1996) 

[Publications] Ronan, P.: "Eﬀect of low frequency magnetic ﬁelds and induced current on DNA digestion." Proc. of Australian University Power

Engineering Conference. 259-262 (1996) 

[Publications] 郡司芳郎: "DNA合成に与える低周波交流磁界の影響" ⽇本⽣体磁気学会誌. 70-73 (1996) 

[Publications] 郡司芳郎: "ミスマッチ修復に及ぼす低周波交流磁場の影響" 電気学会マグネティックス研究会資料. MAG-96-139. 67-72 (1996) 

[Publications] Nafalski, A.: "Measurement of magnetic ﬁelds in urban environment." Proc. of Australian University Power Engineering Conference.

247-252 (1996) 

[Publications] A. Katsuki: "The Effects of High Magnetic Field Effects on the Deposition of Silver." Chem. Lett.219-220 (1996)  [Publications] A.Katsuki: "The Effect of High Magnetic Field on the Crystal Growth of Benzophenone." Chem. Lett.607-608 (1996) 

[Publications] H.Cao: "Magnetic Field Eﬀfects on intramolecular Exdplex Fluorescence of Chaln-Llnked Phenanthrene and N,N-Dimethylaniline :

Inﬂuence of Chain Length,Solvent,and Temperature." Bull. Chem. Soc. Jpn.69. 2801-2813 (1996) 

[Publications] C.-H. Tung: "Benzophenone-lnitiated Photolsomirization of Norbornadlene Group in a Benzophenone-Steroid-Norbomadlene System via

Long-Distance Intramolecular Triplet Energy Transfer." J. Phys. Chem.100. 4480-4484 (1996) 

[Publications] I. Naito: "Formation of Oxonium Ylide Evidenced by the Laser Flash Photolysis of (Biphenyl-4-yl) Chlorodiazirine in Ethers." J. Chem.

Soc. Perkin Trans.2. 725-729 (1996) 

[Publications] M. Yerazima: "Translational Diﬀusion of a Carbene and Radicals Derived from Carbenes." J. Chem. Soc. ,Faraday Trans.92. 2361-236

(1996) 

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[Publications] M. Okazaki: "Control of a Photoreaction by ESR Transition of the Intermediate Radical Pair as Evaluated by Liquid Chromatography." J.

Phys. Chem.100. 9403-940 (1996) 

[Publications] 藤原好恒: "パルス強磁場レーザーフラッシュホトリシス測定装置の開発とその光化学反応へ応⽤" ⽇本電気学会論⽂誌. 116A. 419-423 (1996) 

[Publications] 中垣良⼀: "ラジカル反応における磁気同位体効果" 光化学. 22. 49-53 (1996) 

[Publications] Toshihiro Sassa: "The synaptic protein UNC-18 is phosphorylated by protein kinase C." Neurochemi. Int.29. 543-552 (1996) 

[Publications] Hisamitsu Ogawa: "Expression,Puriﬁcation,and characterization of recombinant C. elegans UNC-18" Neurochemi. Int.29. 553-563

(1996) 

[Publications] 細野隆次: "センチュウにおける性決定の分⼦遺伝学" 科学. 66. 633-640 (1996) 

[Publications] Yamagishi, S.: "Advanced glycation endproducts-driven angiogenesis in vitro." J. Biol. Chem.272. 8723-8730 (1997) 

[Publications] Hayashi, Y.: "Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured

astrocytes." Glia. 19. 13-26 (1997) 

[Publications] Yonemura, Y.: "A possible role of cytokines in the formation of peritoneal dissemination." Int. J. Oncology. 11. 349-358 (1997) 

[Publications] Ogawa, H.: "Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin." J. Biol. Chem.273. 2192-2198

(1998) 

[Publications] Yamagishi, S.: "Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human

microvascular endothelial cells." Diabetologia. (in press). (1998) 

[Publications] Segawa, Y.: "Upregulation of retinal vascular endothelial growth factor mRNAS in spontaneously diabetic rats without ophthalmoscopic

retinopathy." Ophthalmic Res. (in press). (1998) 

[Publications] Kaneko, T.: "Cytidine kinase : A novel pyrimidine ribonucleoside phosphorylating enzyme in Escherichia coli." Nucleosides &

Nucleotides. (in press). (1998) 

[Publications] Yamagishi, S.: "AGE and endothelial cells." Journal od Atherosclerosis and Thrombosis. (in press). (1998) 

[Publications] Noguchi, N.: "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca^<2+> from islet microsome." J. Biol. Chem.272.

3133-3136 (1997) 

[Publications] Narushima, Y: "Structure,Chromosomal localization,and expression of mouse genes encoding type III Reg,RegIIIα,RegIIIβ,RegIIIγ."

Gene. 185. 159-168 (1997) 

[Publications] Nata, K.: "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) : organization,nucleotide sequence and

alternative splicing." Gene. 186. 285-292 (1997) 

[Publications] Takamura, T.: "Transgenic mice overexpressing type 2 nitric oxide synthase in pancreatic β cells develop insulin-dependent diabetes

without insulitis." J. Biol. Chem.273. 2493-2496 (1998) 

[Publications] Harima, Y.: "Phosphorescence and S-T Absrption in Vanadyl (IV) Tetraphenylporphyrin at Room Temperature." Chem. Phys. Lett.267.

481-484 (1997) 

[Publications] Nakagaki, R.: "Magnetic Field and lsotope Eﬀects on Photochemistry of Chain-Linked Compounds Containing Benzophenone and

Hydrogen-Donor Moieties." J. Phys. Chem. A. 101. 556-560 (1997) 

[Publications] Cao, H.: "Eﬀects of High Magnetic Field on the Intramolecular Exciplex Fluorescence of Chain-Linked Phenanthrene and

Dimethylaniline." J. Phys. Chem. A. 101. 407-411 (1997) 

[Publications] Fujiwara, M.: "Spectroscopic Studies on Photochemical Formation of o-Xylylene in Solution." J. Phys. Chem. A. 101. 4912-4915 (1997)  [Publications] Tung, C. -H.: "Intramolecular Long-Distance Electron Transfer and Triplet Energy Transfer. Photophysicaland Photochemical Studies on

a Norbornadiene-Steroid-Benzidine System." J. Am. Chem. Soc.119. 5348-5354 (1997) 

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[Publications] Fujiwara, Y.: "Inﬂuence of Micelles and Magnetic Isotopes on Magnetic Field Deendence of Lifetimes of Benzophenone Ketyl-alkylo

Radical Pairs." Chem. Lett.435-436 (1997) 

[Publications] Fujiwara, Y.: "High Magnetic Field and Magnetic Isotope Eﬀects on Lifetimes of Triplet Biradicals Consisting of Two Equivalent

Benzophenone Ketyls Linked by Methylene Chains." J. Phys. Chem. A. 101. 6842-6849 (1997) 

[Publications] Tanimoto, Y.: "Eﬀect of High Magnetic Field on the Silver Deposition from Its Aqueous Solution." J. Phys. Chem. A. 101. 7359-7363

(1997) 

[Publications] Iwahara, M.: "ICharacterized Hysteresis Model and aMagnetic Pulse Compression Circuit" J. of Electrical Engineering. 48. 24-25 (1997) 

[Publications] Mukhopadhyay, S. C.: "Disturbance Attenuation and Control on Repulsive Type Magnetic Bearing" IEEE Trans. on Magnetics. 33. 4233-

4235 (1997) 

[Publications] Yamada, S.: "Investigation of Printed Wiring Board Testing By Using Planar Coil ECT Probe." IEEE Trans. on Magnetics. 33. 3376-3378

(1997) 

[Publications] Mukherjee, A.: "Transient Simulation of a Transformer Core Demagnetization Scheme." ⽇本応⽤磁気学会論⽂誌. 22(in press). (1998) 

[Publications] Mukhopadhyay, S. C.: "Design and Performance Analysis by Means of Tableau Approach of Passive Fault Current Limiter using Steel

Core." Journal on Magnetism and Magnetic Materials. (in press). (1998) 

[Publications] Yamada, S.: "Flux-Concentration Type Electromagnetic Pump for Transferring Sodium." Journal of Applied Electromagnetics and

Mechanics. (in press). (1998) 

[Publications] Mukhopadhyay, S. C.: "Design and Development of a Low Cost Repulsive Type Magnetic Bearing and its H ∞ Control." Journal of

Applied Electromagnetics and Mechanics. (in press). (1998) 

[Publications] Iwahara, M.: "A Full Passive Fault Current Limiter Using the Permanent Magnet for the Burden Critical Equipment." Journal of Applied

Electromagnetics and Mechanics. (in press). (1998) 

[Publications] Mukhopadhyay, S. C.: "Comparative Studies of Levitation and Control Performances of Two Types of Single-Axis Controlled Repulsive

Type Magnetic Bearing." Publication of NASA Periodicals. (in press). (1998) 

[Publications] Mukhopadhyay, S. C.: "Investigation of the Performances of a Permanent Magnet Biased Fauit Current Limiting Reactor with a Stool

Core." IEEE Trans. on Magnetics. (in press). (1998) 

[Publications] Young, S.: "A Comparison between a Two-Material and Three-Material Magnetic Current Limiter." IEEE Trans. on Magnetics. (in press).

(1998) 

[Publications] Lu, J.: "Application and Analysis of a Adjustable Proﬁle High Frequency Switchmode Transformer Having a U-Shaped Winding

Structure." IEEE Trans. on Magnetics. (in press). (1998) 

[Publications] 野村素弘: "⾎管の再構築とその病態" 最新医学社, 138 (1995) 

[Publications] ⼭本博: "VEGF、動脈硬化+⾼脂⾎症研究ストラテジー" 秀潤社, 464 (1996) 

[Publications] ⼭岸昌⼀: "周⽪細胞、「⾎管新⽣のメカニズムと疾患」" 医薬ジャーナル社, 287 (1996) 

[Publications] ⼭本博: "KEY WORD 1996-'97『炎症・免疫系』" 先端医学社, 191 (1996) 

[Publications] Hiroshi Yamamoto: "Contemporary approaches tcward cure of gastric cancer" Maeda Shoten Co. ,Ltd., 197 (1996) 

[Publications] Yutaka Yonemura: "腹膜播種(Peritoneal Dissemination)" へるす出版, 134 (1996) 

[Publications] ⾕本能⽂: "「分⼦磁性」軽原⼦ラジカルの反応に対する磁場効果" 伊藤公⼀編学会出版センター, 311-318,335-339 (1996) 

[Publications] ⼭本博: "「医学のための基礎分⼦細胞⽣物学」細胞の基本構造、⽼化、遺伝病(1)、遺伝病(2)、⾎管新⽣" 南⼭堂, 122 (1997) 

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[Publications] ⼭岸昌⼀: "「⾎管新⽣のメカニズムと疾患」周⽪細胞" 医薬ジャーナル社, 287 (1997) 

[Publications] ⼭本博: "『⾎管と内⽪』特集:内⽪のストレスとその応答" メディカルレビュー社(印刷中), (1998) 

[Publications] ⽶倉秀⼈: "「医学のための基礎分⼦細胞⽣物学」インスリン、グルカゴン、⾎管作動性物質" 南⼭堂, 122 (1997) 

[Publications] ⽶倉秀⼈: "キーワード'98-99「⾼脂⾎症・動脈硬化」第3章⾎管新⽣" 先端医学社(印刷中), (1998) 

[Publications] 細野隆次: "ネオ⽣物学「線⾍」C. elegansニューロン" 共⽴出版, 153 (1997) 

[Publications] 細野隆次: "「医学のための基礎分⼦細胞⽣物学」シナプス伝達、神経⾼次機能、アルツハイマー病・パーキンソン病" 南⼭堂, 122 (1997) 

[Publications] Bessho, K., Yamada, S., Kunitani, T., Nakamura, T., Hashiguchi, T., Tanimoto, Y., Harada, S., Yamamoto, H.and Hosono, R.: "Biological responses in Caenorhabditis elegans to high magnetic ﬁelds." EXPERIENTIA. 51 (3). 284-288 (1995) 

[Publications] Nomura, M., Yamagishi, S., Harada, S., Hayashi, Y., Yamashima, T., Yamashita, J.and Yamamoto, H.: "Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-Induced Proliferation of Endothelial Cells and Pericytes." The Journal of Biological Chemistry. 270 (47). 28316-28324 (1995)



[Publications] Yamagishi, S., Hsu, C.-C., Taniguchi, M., Harada, S., Ohsawa, K., Kobayashi, K.and Yamamoto, H.: "Receptor-Mediated Toxicity to Pericytes of Advanced Glycosylation End Products : A Possible Mechanism of Pericyte Loss in Diabetic Microangiopathy."

Biochem.Biophys.Res.Commun.213 (2). 681-687 (1995)

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[Publications] Uchiyama, K., Asano, N., Ogata, M., Tanahashi, T., Torisaki, M., Mochizuki, K., Kawasaki, K., Kojima, M., Sasaki, K., Ishibashi, Y., Hsu, C.-C.Kaneko, T., Yamamoto, H.: "TOPICAL FLUCONAZOLE : HIGH PENETRATION WITHOUT CORNEAL TOXICITY." Ocular Toxicology. 181-190. (1995) 

[Publications] Nakashima, E., Matsushita, R., Negishi, H., Nomura, M., Harada, S., Yamamoto, H., Miyamoto, K.and Ichimura, F.: "Reversal of Drug Sensitivity in MDR Subline of P388 Leukemia by Gene-Targeted Antisense Oligonucleotide." Journal of Pharmaceutical Sciences. 84 (10). 1205-1209 (1995)

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[Publications] Takeda, R., Hatakeyama, H., Takeda, Y., Iki, K., Miyamori, I., Sheng, W.P., Yamamoto, H.and Blair, I.A.: "Aldosterone biosynthesis and

action in vascular cells." Steroids. 60 : 1. 120-124 (1995) 

[Publications] Takanaga, H., Tamai, I., Inaba, S., Sai, Y., Higashida, H., Yamamoto, H.and Tsuji, A.: "cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter." Biochem.Biophys.Res.Commun.217, No.1. 370-377 (1995) 

[Publications] H.Miyasaka, M.Kiri, K.Morita, N.Mataga, and Y.Tanimoto: "Picosecond Laser Photolysis Studies on Chain-Length, Solvent and Temperature Dependences of the Intramolecular Photoreduction Process of Benzophenone by Diphenylamine." Bull.Chem.Soc.Jpn.68. 1569-1582 (1995)



[Publications] N.E.Polyakov, M.Okazaki, H.Fukaya, Y.Fujiwara, and Y.Tanimoto: "Photochemistry of Acetylenic Ketones in Micellar Solutions as Studied by Product-Yield-Detected ESR and Transient Absorption Techniques." Photochem.Photobiol.61. 545-551 (1995) 

[Publications] I.Naito, Y.Fujiwara, Y.Tanimoto, A.Ishida, and S.Takamuku: "3-Dipolar Addition of a Nitrile Ylide with Carbonyl Compounds Studied by Laser Flash Photolysis of 3-(Biphenyl-4-yl)-2H-azirine." Bull.Chem.Soc.Jpn.68. 2905-2908 (1995) 

[Publications] H.Cao, K.Miyata, T.Tamura, Y.Fujiwara, Y.Tanimoto, M.Okazaki, K.Iwai, and M.Yamamoto: "Eﬀect of High Magnetic Field on the Decay Rate of Chain-Linked Intramolecular Exciplex Fluorescence." Chem.Phys.Lett.246. 171-175 (1995) 

[Publications] H.Cao, Y.Akimoto, Y.Fujiwara, Y.Tanimoto, L.-P.Zang, and C.-H.Tung: "A Laser Flash Photolysis Study of the Intramolecular Energy Transfer Reaction from Benzophenone to Norbornadiene Covalently Bonded by a Rigid Steroid Bridge." Bull.Chem.Coc.Jpn. 68. 3411-3415 (1995) 

[Publications] A.Katsuki, S.Watanabe, R.Tokunaga, and Y.Tanimoto: "The Eﬀects of High Magnetic Field on the Deposition of Silver." Chem.Lett.219-

220 (1996) 

[Publications] I.Naito, Y.Fujiwara, Y.Tanimoto, A.Ishida, and S.Takamuku: "1,3-Dipolar Addition of Nitrile Ylide to Oleﬁns Using the Laser Flash

Photolysis 3-(Biphenyl-4-yl)-2H-azirine." J.Photochem.Photobiol.A92. 73-77 (1995) 

[Publications] F.P.Dawson, S.Yamada, M.Iwahara: "Experimental Results for a Two-Material Passive di/dt Limiter" IEEE Trans.on Magnetics. 31 (6).

3734-3736 (1995) 

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[Publications] S.Yamada, M.Katou, M.Iwahara, F.P.Dawson: "Eddy Current Testing Probe Composed of Planar Coils" IEEE Trans on Magnetics. 31 (6).

3185-3187 (1995) 

[Publications] J.Lu, F.P.Dawson, S.Yamada: "Analysis of High Frequency Planar Sandwich Transformers for Switching Converters" IEEE Trans.on

Magnetics. 31 (6). 4235-4237 (1995) 

[Publications] Hiroshi Yamamoto: ""Vascular VEGF" in Hypoxia-Induced Proliferation of Vascular Cells." Microcirculation Annual. Vol.11. 11-12 (1996) 

[Publications] Kaji, M., Yonemura, Y., Harada, S., Liu, X., Terada, I.and Yamamoto, H.: "Participation of c-met in the progression of human gastric cancers ; Anti-c-met oligonucleotides inhibit proliferation or invasiveness of gastric cancer cells." Cancer Gene Therapy. 3 (6). 393-404 (1996) 

[Publications] Yamagishi, S., Yamamoto, Y., Harada, S., Hsu, C.-C.and Yamamoto, H.: "Advanced glycosylation end products stimulate the growth but inhibit the prostacyclin-producing ability of endothelial cells through interactions with their receptors." FEBS Lett.384. 103-106 (1996) 

[Publications] Yamamoto, Y., Yamagishi, S., Hsu, C.-C.and Yamamoto, H.: "Advanced glycation endproducts-receptor interactions stimulate the growth of human pancreatic cancer cells through the induction of platelet-derived growth factor-B." Biochem.Biophys.Res.Commun.222 (3). 700-703 (1996)



[Publications] Yonemura, Y., Kaji, M., Hirono, Y., Fushida, S., Tsugawa, K., Fujimura, T., Miyazaki, I., Harada, S., Yamamoto, H.: "Correlation between overexpression of c-met gene and the progression of gastric cancer." Int.J.Oncology. 8. 555-560 (1996) 

[Publications] Hatakeyama, H., Miyamori, I., Takeda, Y., Yamamoto, H.and Mabuchi, H.: "The expression of steroidogenic enzyme genes in human

vascular cells." Biochemistry and Molecular Biology International. 40 (3). 639-645 (1996) 

[Publications] Hirono, Y., Fushida, S., Yonemura, Y., Yamamoto, H., Watanabe, H., and Raz, A.: "Expression of autocrine motility factor receptor

correlates with disease progression in human gastric cancer." British Journal of Cancer. 74. 2003-2007 (1996) 

[Publications] Yamada, S., Kawasaki, M., Gunji, Y., Ronan, P., Harada, S., Yamamoto, H.: "Eﬀects of low frequency magnetic ﬁelds on DNA synthesis."

IEEE Trans.on Magnetics. 32 (6). 5115-5117 (1996) 

[Publications] Yonekura, H., Anzai, T., Kato, I., Furuya, Y., Shizuta, S., Takasawa, S., and Okamoto, H: "Identiﬁcation of the ﬁve essential histidine

residues for peptidylglycine monooxygenase." Biochem.Biophys.Res.Commun.218. 495-499 (1996) 

[Publications] C.-H.Tung, L.-P.Zhang, Y.Li, H.Cao, and Y.Tanimoto: "Benzophenone-Initiated Photoisomirization of Norbornadiene Group in a

Benzophenone-Steroid-Norbornadiene System via Long-Distance Intramolecular Triplet Energy Transfer." J.Phys.Chem.100. 4480-4484 (1996) 

[Publications] I.Naito, A.Oku, N.Otani, Y.Fujiwara, and Y.Tanimoto: "Formation of Oxonium Ylide Evidenced by the Laser Flash Photolysis of (Biphenyl-

4-yl) Chlorodiazirine in Ethers." J.Chem.Soc.Perkin Trans. 2. 725-729 (1996) 

[Publications] M.Terazima, H.Tomioka, K.Hirai, Y.Tanimoto, Y.Fujiwara, and Y.Akimoto: "Translational Diﬀusion of a Carbene and Radicals Derived from

Carbenes." J.Chem.Soc., Faraday Trans.92 (13). 2361-2368 (1996) 

[Publications] M.Okazaki, Y.Tanimoto, Y.Konishi, and K.Toriyama: "Control of a Photoreaction by ESR Transition of the Intermediate Radical Pair as

Evaluated by Liquid Chromatography." J.Phys.Chem.100. 9403-9406 (1996) 

[Publications] Y.Fujiwara, T.Aoki, K.Yoda, H.Cao, .Mukai, T.Haino, Y.Fukazawa, Y.Tanimoto, H.Yonemura, T.Matsuo, M.Okazaki: "Eﬀect of High Magnetic Fields on the Reverse Electron Transfer Process in an alpha-Cyclodextrin Inclusion Complex of Phenothiazine-Viologen Chain-Linked Compound." Chem.Phys.Lett.259. 361-367 (1996)



[Publications] A.Katsuki, R.Tokunaga, S.Watanabe, and Y.Tanimoto: "The Eﬀect of High Magnetic Field on the Crystal Growth of Benzophenone."

Chem.Lett.607-608 (1996) 

[Publications] H.Cao, Y.Fujiwara, T.Haino, Y.Fukazawa, C.Tung, and Y.Tanimoto: "Magnetic Field Eﬀects on Intramolecular Exciplex Fluorescence of Chain-Linked Phenanthrene and N,N-Dimethylaniline : Inﬂuence of Chain Length, Solvent, and Temperature." Bull.Chem.Soc.Jpn.69. 2801-2813 (1996)



[Publications] N.Ohta, M.Koizumi, Y.Mishimura, I.Yamazaki, Y.Tanimoto, Y.Hatano, M.Yamamoto, and H.Kono: "External Electric Field Eﬀects on Fluorescence of Methylene-Linked D-A Systems in Polymer Films : (Carbazole) - (CH2)n- (Terephthalic Acid Methyl Ester)." J.Phys.Chem.100. 19295- 19302 (1996)

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[Publications] N.Ogita, T.Minami, Y.Tanimoto, O.Fujita, J.Akimitsu, P.Lemmens, G.Guntherodt, and M.Udagawa: "Raman Scattering Study of Phonon and Magnetic Excitations along the Magnetic Chain in CuGeO3." J.Phys.Chem.Jpn. 65. 3754-3757 (1996)



[Publications] J.Lu, S.Yamada, H.B.Harrison: "Application of Harmonic Balance-Finite Element Method (HBFEM) in the Design of Switching Power

Supplies" IEEE Trans.Power Electronics. 11 (2). 347-355 (1996) 

[Publications] S.Yamada, M.Katou, M.Iwahara, F.P.Dawson: "Defect Images by Planar ECT Probe of Meander-Mesh Coils" IEEE Trans.on Magnetics.

MAG-32,6. 4956-4958 (1996) 

[Publications] Ogawa, H., Hayashi, N., Hori, I., Kobayashi, T.and Hosono, R.: "Expression, Puriﬁcation, and Characterization of Recombinant C.elegans

UNC-18." Neurochemistry International. 29 (5). 553-563 (1996) 

[Publications] Sassa T., Ogawa, H., Kimoto, M.and Hosono, R.: "The Synaptic Protein UNC-18 is Phosphorylated by Protein kinase C." Neurochemistry

International. 29 (5). 543-552 (1996) 

[Publications] Hayashi, Y., Nomura, M., Yamagishi, S., Harada, S., Yamashita, J.and Yamamoto, H.: "Induction of various blood-brain barrier

properties in non-neural endothelial cells by close apposition to co-cultured astrocytes." Glia. 19. 13-26 (1997) 

[Publications] Yamagishi, S., Yonekura, H., Yamamoto, Y., Katsuno, K., Sato, F., Mita, I., Ooka, H., Satozawa, N., Kawakami, T., Nomura, M.and Yamamoto, H.: "Advanced glycation endproducts-driven angiogenesis in vitro : Induction of the growth and tube formation of human microvascular endothelial cells through autocrine vascular endothelial growth factor." J.Biol.Chem.272 (13). 8723-8730 (1997)



[Publications] Yonemura, Y., Endou, Y., Nojima, N,.Kawamura, T., Fujita, H., Kaji, M., Ajisaka, H., Bandou, E., Sasaki, T., Yamaguchi, T., Harada, S.and Yamamoto, H.: "A possible role of cytokines in the formation of peritoneal dissemination." International Journal of Oncology. 11. 349-358 (1997) 

[Publications] Noguchi, N., Takasawa, S., Nata, K., Tohgo, A., Kato, I., Ikehata, F., Yonekura, H., and Okamoto, H.: "Cyclic ADP-ribose binds to FK506- binding protein 12.6 to release Ca_<2+> from islet microsome." J.Biol.Chem.272. 3133-3136 (1997) 

[Publications] Narushima, Y., Unno, M., Nakagawara, K., Mori, M., Miyashita, H., Suzuki, Y., Noguchi, N., Takasawa, S., Kumagai, T., Yonekura, H., and Okamoto, H.: "Structure, chromosomal localization, and expression of mouse genes encoding type III Reg, RegIIIalpha, RegIIIbeta, RegIIIgamma."

Gene. 185. 159-168 (1997)



[Publications] Nata, K., Takamura, T., Karasawa, T., Kumagai, T., Hashioka, W., Tohgo, A., Yonekura, H., Takasawa, S., Nakamura, S., and Okamoto, H.: "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) : organization, nucleotide sequence and alternative splicing."

Gene. 186. 285-292 (1997)



[Publications] Y.Harima, T.Kodaka, Y.Kunugi, K.Yamashita, Y.Akimoto, Y.Fujiwara, and Y.Tanimoto: "Phosphorescence and S-T Absorption in Vanadyl

(IV) Tetraphenylporphyrin at Room Temperature." Chem.Phys.Lett.265. 481-484 (1997) 

[Publications] R.Nakagaki, M.Yamaoka, O.Takahira, K.Hiruta, Y.Fujiwara, and Y.Tanimoto: "Magnetic Field and Isotope Eﬀects on Photochemistry of Chain-Linked Compounds Containing Benzophenone and Hydrogen-Donor Moieties." J.Phys.Chem.A.101. 556-560 (1997) 

[Publications] H.Cao, K.Miyata, T.Tamura, Y.Fujiwara, A.Katsuki, C.-H.Tung, and Y.Tanimoto: "Eﬀects of High Magnetic Field on the Intramolecular Exciplex Fluorescence of Chain-Linked Phenanthrene and Dimethylaniline." J.Phys.Chem.A.101. 407-411 (1997) 

[Publications] M.Fujiwara, K.Mishima, K.Tamai, Y.Tanimoto, K.Mizuno, and Y.Ishii: "Spectroscopic Studies on Photochemical Formation of o-Xylylene in

Solution." J.Phys.Chem.A.101. 4912-4915 (1997) 

[Publications] C.-H.Tung, L.-P.Zhang, Y.Li, H.Cao, and Y.Tanimoto: "Intramolecular Long-Distance Electron Transfer and Triplet Energy Transfer.

Photophysical and Photochemical Studies on a Norbornadiene-Steroid-Benzidine System." J.Am.Chem.Soc.119. 5348-5354 (1997) 

[Publications] Y.Fujiwara, K.Yoda, T.Aoki, and Y.Tanimoto: "Inﬂuence of Micelles and Magnetic Isotopes on Magnetic Field Deendence of Lifetimes of

Benzophenone Ketyl-alkylo Radical Pairs." Chem.Lett.435-436 (1997) 

[Publications] Y.Fujiwara, T.Aoki, T.Haino, Y.Fukazawa, Y.Tanimoto, R.Nakagaki, O.Takahira, and M.Okazaki: "High Magnetic Field and Magnetic Isotope Eﬀects on Lifetimes of Triplet Biradicals Consisting of Two Equivalent Benzophenone Ketyls Linked by Methylene Chains." J.Phys.Chem.A. 101.

6842-6849 (1997)



[Publications] Y.Tanimoto, A.Katsuki, H.Yano, and S.Watanabe: "Eﬀect of High Magnetic Field on the Silver Deposition from Its Aqueous Solution."

J.Phys.Chem.A. 101. 7359-7363 (1997) 

[Publications] K.Enjo, K.Maeda, H.Murai, T.Azumi, and Y.Tanimoto: "Reaction-Yield-Detected Magnetic Resonance in the Intramolecular and

Intermolecular Electron Transfer Reactions." Appl.Magn.Reson.12. 423-430 (1997) 

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[Publications] K.Enjo, K.Maeda, H.Murai, T.Azumi, and Y.Tanimoto: "Eﬀect of Polymethylene-Chain Dynamics on the Lifetime of a Charge -Separated

Biradical Studied by RYDMR Spectroscopy." J.Phys.Chem.B. 101. 10661-10665 (1997) 

[Publications] M.Iwahara, S.Yamada: "Characterized Hysteresis Model and a Magnetic Pulse Compression Circuit" J.of Electrical Enigineering. 48

(8/5). 24-25 (1997) 

[Publications] S.C.Mukhopadhyay, T.Ohji, M.Iwahara, S.Yamada, F.Matsumura: "Disturbance Attenuation and H* Control on Repulsive Type Magnetic

Bearing." IEEE Trans.on Magnetics. 33 (5). 4233-4235 (1997) 

[Publications] S.Yamada, H.Fujiki, M.Iwahara, S.C.Mukhopadhyay, F.P.Dawson: "Investigation of Printed Wiring Board Testing By Using Planar Coil

Type ECT Probe." IEEE Trans.on Magnetics. 33 (5). 3376-3378 (1997) 

[Publications] Ogawa, H., Harada, S., Sassa, T., Yamamoto, H.and Hosono, R.: "Functional properties of the unc-64 gene encoding a Caenorhabditis

elegans syntaxin." J.Biol.Chem.273 (4). 2192-2198 (1998) 

[Publications] Segawa, Y., Shirao, Y., Yamagishi, S., Yamamoto, H.et al.: "Upregulation of retinal vascular endothelial growth factor mRNAs in

spontaneously diabetic rats without ophthalmoscopic retinopathy." Ophthalmic Res.(in press). (1998) 

[Publications] Kaneko, T., Yamamoto, H.: "Cytidine kinase : A novel pyrimidine ribonucleoside phosphorylating enzyme in Escherichia coli."

Nucleosides & Nucleotides. (in press). (1998) 

[Publications] Yamagishi, S., Yonekura, H., Yamamoto, H.: "AGE and Endothelial Cell." Journal of Atherosclerosis and Thrombosis. 4 (4) (in press).

(1998) 

[Publications] Yamagishi, S., Fujimori, H., Yonekura, H., Yamamoto, Y.and Yamamoto, H.: "Advanced Glycation Endproducts Inhibit Prostacyclin

Production and Induce Plasminogen Activator Inhibitor-1 in Human Microvascular Endothelial Cells." Diabetologia. (in press). (1998) 

[Publications] Takamura, T., Kato, I., Kimura, N., Nakazawa, T., Yonekura, H., Takasawa, S., and Okamoto, H.: "Transgenic mice overexpressing type 2 nitric oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis." J.Biol.Chem.273. 2493-2496 (1998) 

[Publications] S.C.Mukhopadhyay, M.Iwahara, S.Yamada, F.P.Dawson: "Design and Performance Analysis by Means of Tableau Approach of Passive Fault Current Lilmiter using Steel Core" Journal on Magnetism and Magnetic Materials. Elsevier Science (to be published). (1998) 

[Publications] S.Yamada, M.Iwahara, T.Minamizono: "Flux-Concentration Type Electromagnetic Pump for Transferring Sodium" Journal of Applied

Electromagnetics and Mechanics. IOS Press (to be published). (1998) 

[Publications] S.C.Mukhopadhyay, T.Ohji, M.Iwahara, S.Yamada, F.Matsumura: "Design and Development of a Low Cost Repulsive Type Magnetic Bearing and its H* Control" Journal of Applied Electromagnetics and Mechanics. IOS Press (to be published). (1998) 

[Publications] M.Iwahara, S.C.Mukhopadhyay, S.Yamada and F.P.Dawson: "A Full Passive Fault Current Limiter Using the Permanent Magnet for the Burden Critical Equipment" Journal of Applied Electromagnetics and Mechanics. IOS Press (to be published). (1998) 

[Publications] S.C.Mukhopadhyay, T.Ohji, T.Kuwahara, M.Iwahara, S.Yamada, F.Matsumura: "Comparative Studies of Levitation and Control

Performances of Two Types of Single-Axis Controlled Repulsive Type Magnetic Bearing" Publication of NASA periodicals. (to be published). (1998) 

[Publications] S.C.Mukhopadhyay, M.Iwahara, S.Yamada, F.P.Dawson: "Investigation of the Performances of a Permanent Magnet Biased Fault Current

Limiting Reactor with a Steel Core." IEEE Trans.on Magnetics. (to be published). (1998) 

[Publications] S.Young, F.P.Dawson, M.Iwahara, S.Yamada: "A Comparison between a Two-Material and Three-Material Magnetic Current Limiter."

IEEE Trans.on Magnetics. (to be published). (1998) 

[Publications] J.Lu, F.P.Dawson, S.Yamada: "Application and Analysis of a Adjustable Proﬁle High Frequency Switchmode Transformer Having a U-

Shaped Winding Structures." IEEE Trans.on Magnetics. (to be published). (1998) 

[Publications] Kato, I., Suzuki, Y., Akabane, A., Yonekura, H., Tanaka, O., Kondo, N., Takasawa, S., Yoshimoto, T., and Okamoto, H.: "Enhancement of glucose-induced insulin secretion in transgenic mice overexpressing human VIP gene in pancreatic beta cells" Annal.N.Y.Acad.Sci.805. 232-243 (1996)

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[Publications] Hiroshi Yamamoto: Contemporary approaches toward cure of gastric cancer (Edited by Yutaka Yonemura. Maeda Shoten Co., Ltd, 1-

197 (1996) 

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Published: 1999-03-15 URL: https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-07558203/075582031997kenkyu_seika_hokoku_