Acta Medica Okayama
Volume 37, Issue 4 1983 Article 4
A UGUST 1983
Effect of a branched chain amino acid-enriched nutritional product on the pathophysiology of the liver and nutritional
state of patients with liver cirrhosis.
Akiharu Watanabe
∗Tetsuya Shiota
†Misako Okita
‡Hideo Nagashima
∗∗∗Okayama University,
†Okayama University,
‡Okayama University,
∗∗Okayama University,
Copyright c1999 OKAYAMA UNIVERSITY MEDICAL SCHOOL. All rights reserved.
Effect of a branched chain amino acid-enriched nutritional product on the pathophysiology of the liver and nutritional
state of patients with liver cirrhosis. ∗
Akiharu Watanabe, Tetsuya Shiota, Misako Okita, and Hideo Nagashima
Abstract
A new nutritional product (SF-1008C) containing a high proportion of branched chain amino acids (BCAA) and low proportion of aromatic amino acids (AAA) and methionine was tested to see its effect on the impaired protein metabolism and abnormal nutritional state frequently observed in patients with advanced liver cirrhosis. A sharp increase in plasma BCAA levels and fall of AAA and methionine levels were found following the administration of an SF-1008C- supplemented diet to healthy controls and cirrhotic patients, which the BCAA levels increased only slightly following an isocaloric control diet. Blood ammonia levels increased within the normal range transiently following the diets. The SF-1008C-supplemented diet was given for 2 weeks to cirrhotic patients with histories of hepatic encephalopathy, who were taking a low-protein diet because of hyperammonemia. Serum prealbumin levels, nitrogen balance, molar ratio of plasma BCAA/phenylalanine and tyrosine, the number connection test and electroencephalograms improved during the period of the experimental diet. The results, therefore, indicate that a BCAA- supplemented diet is well tolerated by patients with advanced cirrhosis and useful for treatment of impaired protein metabolism. Furthermore, this product is beneficial in preventing hepatic encephalopathy in cirrhotics.
KEYWORDS:branched chain amino acid, aromatic amino acid, nutritional product, liver cirrho- sis, hepatic encephalopathy
∗PMID: 6624532 [PubMed - indexed for MEDLINE]
Copyright (C) OKAYAMA UNIVERSITY MEDICAL SCHOOL
1 Watanabe et al.: Effect of a branched chain amino acid-enriched nutritional
Produced by The Berkeley Electronic Press, 1983
2 Acta Medica Okayama, Vol. 37 [1983], Iss. 4, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss4/4
3 Watanabe et al.: Effect of a branched chain amino acid-enriched nutritional
Produced by The Berkeley Electronic Press, 1983
4 Acta Medica Okayama, Vol. 37 [1983], Iss. 4, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss4/4
5 Watanabe et al.: Effect of a branched chain amino acid-enriched nutritional
Produced by The Berkeley Electronic Press, 1983
6 Acta Medica Okayama, Vol. 37 [1983], Iss. 4, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss4/4
7 Watanabe et al.: Effect of a branched chain amino acid-enriched nutritional
Produced by The Berkeley Electronic Press, 1983
8 Acta Medica Okayama, Vol. 37 [1983], Iss. 4, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss4/4
9 Watanabe et al.: Effect of a branched chain amino acid-enriched nutritional
Produced by The Berkeley Electronic Press, 1983
10 Acta Medica Okayama, Vol. 37 [1983], Iss. 4, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss4/4
11 Watanabe et al.: Effect of a branched chain amino acid-enriched nutritional
Produced by The Berkeley Electronic Press, 1983
12 Acta Medica Okayama, Vol. 37 [1983], Iss. 4, Art. 4
http://escholarship.lib.okayama-u.ac.jp/amo/vol37/iss4/4
13 Watanabe et al.: Effect of a branched chain amino acid-enriched nutritional
Produced by The Berkeley Electronic Press, 1983
