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(1)

100

0 60 80

40

20

W it h d ra w a l re sp o n se f re q u e n cy (% )

ns ns

Before!

i.t.

During!

i.t.

After!

i.t.

Befor After!

i.t. IFN i.t. Saline

* *

†

(6) (6)

Figure 1

Attenuation of mechanical allodynia by intrathecal IFN

(2)

!

!

!

!

!

!

0 60 80

40

20

W it h d ra w a l re sp o n se f re q u e n cy (% )

i.t . I F N + i.p . Sa lin e

i.t . I F N + i.p . N T L

i.t . I F N + i.p . N AL

ns

*

*

(5) (5) (5)

Figure 2

Reversal of the analgesic effect of intrathecal IFN by intraperitoneal

administration of NTL (blue bar) and NAL (green bar)

(3)

†

ns ns

*

*

Before!

i.t.

During!

i.t.

After!

i.t.

i.t. Saline i.t. CTX

W it h d ra w a l re sp o n se f re q u e n cy (%

) 100 80 60 40 20 0

(6) (6)

Figure 3

(4)

i.t . C

T X + i.p . Sa lin e

i.t . C

T X + i.p . N T L

i.t . C

T X + i.p . N AL

!

!

!

!

!

!

100

0 60 80

40

20

W it h d ra w a l re sp o n se f re q u e n cy (% )

0 60 80

40

20

W it h d ra w a l re sp o n se f re q u e n cy (% )

ns

*

*

(5) (5) (5)

Figure 4

Reversal of the analgesic effect of intrathecal CTX by intraperitoneal

administration of NTL (blue bar) and NAL (green bar)

(5)

i.t. CTX

i.t . I F N + i.t . C T X i.t. IFN

i.t . Sa lin e

!

!

!

!

!

!

100

0 60 80

40

20

W it h d ra w a l re sp o n se f re q u e n cy (% )

ns

ns ns

*

*

*

(5) (5) (5) (5)

Figure 5

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