㸰; ⥺ᅇᢡ ᐃ

䝘䝜✵㛫୰䛻㛢䛨㎸䜑䜙䜜䛯ᾮయ䛿≉␗䛺ᵓ㐀ᙧᡂ䛻䜘䜚䚸䝞䝹䜽䛸䛿ⴭ䛧䛟␗䛺䜛≉ᛶ䜢♧䛩䛣䛸䛜▱䜙䜜䛶䛔䜛䚹䛭䛣䛷䚸㧗㍤ᗘ䛺 X ⥺䛜ᚓ䜙䜜䜛 SPring-8 䛷䛾ᐇ㦂䛾䛯䜑䛾⿦⨨〇స 䛧䚸ᾮయ䝘䝜ⷧ⭷䛾 X ⥺ᅇᢡ ᐃ䜢ᐇ⌧䛧䚸ᵓ㐀䛸≉ᛶ䛾┦

㛵䜢ゎ᫂䛩䜛᪉ἲㄽ䜢☜❧䛩䜛䛣䛸䜢┠ᣦ䛧䛶䛔䜛 (ᅗ 5)䚹᫖

ᖺ䛿䚸ཌ䜏⣙ 2 nm 䛾䝇䝯䜽䝏䝑䜽ᾮᬗ 8CB 䛾 X ⥺ᅇᢡ ᐃ䜢

⾜䛔䚸୍㍈㓄ྥ䛧䛯䝷䝯䝷࿘ᮇ䛻ᑐᛂ䛩䜛ᅇᢡ䝢䞊䜽䜢ほ䛷䛝䛯䚹ᮏᖺ䛿䚸䛣䛾䝢䞊䜽䛾⤒᫬ኚ໬䜢 11 ศ㛫㝸䛷 ᐃ䛧䚸᫬

㛫⤒㐣䛻క䛔䚸䝢䞊䜽ᙉᗘ䛾ῶᑡ䚸್༙ᖜቑ኱䜢ほ䛩䜛䛣䛸䛜䛷䛝䛯 ( ᅗ 6) 䚹䛣䜜䛿䚸⾲㠃䛾᥋㏆㐣⛬䛷ὶື㓄ྥ䛧䛯 8CB 䛾ᵓ㐀つ๎ᛶ䛜䚸᫬㛫⤒㐣䛻క䛳䛶⦆࿴䛧䛯䛣䛸䛻䜘䜛䛸

⪃䛘䜙䜜䜛䚹䛣䛾䜘䛖䛻䚸䝘䝜ⷧ⭷䛾ᵓ㐀䛸䛭䛾⦆࿴㐣⛬䜢ホ ౯䛩䜛䛣䛸䛜ྍ⬟䛸䛺䛳䛯䚹

㸱㸬⏕యศᏊ㛫┦஫స⏝ࡢ┤᥋ ᐃ࡟㛵ࡍࡿ◊✲

⏕యෆ䛷䛿䝍䞁䝟䜽㉁䜔 DNA 䛸䛔䛳䛯⏕యศᏊྠኈ䛜┦

஫స⏝䛩䜛䛣䛸䛷⏕࿨άື䛻㔜せ䛺཯ᛂ䛜㐍⾜䛩䜛䚹䛭䛾䛯䜑䚸⏕యศᏊ㛫┦஫స⏝䛾ゎ᫂䛿⏕࿨⌧㇟䜢⌮ゎ䛩䜛ୖ䛷 ᚲ㡲䛺ㄢ㢟䛷䛒䜛䛜䚸䛣䜜䜙䜢⡆౽䛻䛛䛴⢭ᐦ䛻 ᐃ䛩䜛䛯䜑䛾ᡭἲ䛜☜❧䛥䜜䛶䛚䜙䛪䚸ᇶ┙䛸䛺䜛᝟ሗ䛴䜎䜚┦஫స⏝

䛻㛵䜟䜛䜰䝭䝜㓟䛻䛴䛔䛶䛾᝟ሗ䛜ᑡ䛺䛔䚹ᚑ䛳䛶䚸⏕యศᏊ 㛫䛾┦஫స⏝䜢䜰䝭䝜㓟༢఩䛷㆟ㄽ䛷䛝䜜䜀䚸䝥䝻䝔䜸䞊䝮◊

✲䛻᭷⏝䛺▱ぢ䜢୚䛘䜛䛸⪃䛘䜙䜜䜛䚹䛭䛣䛷䚸䝙䝽䝖䝸༸ⓑ䝸䝌䝏䞊䝮 (wild type 䠈 1 䜰䝭䝜㓟ኚ␗య (K97A 䠈 K97M)) 䛸䚸䛭䛾 ᢠయ HyHEL 10 scFv 㛫䛾┦஫స⏝䜢䝁䝻䜲䝗䝥䝻䞊䝤ཎᏊ㛫 ຊ㢧ᚤ㙾䠄 AFM 䠅䛻䜘䜚 ᐃ䛧䚸 1 䜰䝭䝜㓟ኚ␗䛻䜘䜛┦஫స⏝

䜈䛾ᙳ㡪䜢ホ౯䛧䛯䚹

䛭䛾⤖ᯝ䚸wild type 䛾䝸䝌䝏䞊䝮 - HyHEL10scFv 㛫䛷䛾䜏

≉␗ⓗ┦஫స⏝䛻㉳ᅉ䛩䜛ᘬຊ䛜ほᐹ䛥䜜䛯䚹 1 䜰䝭䝜㓟ኚ␗

య䠄 K97A, K97M 䠅 - HyHEL10scFv 㛫䛷䛿㟁Ẽ஧㔜ᒙ᩺ຊ䛾䜏䛜ほᐹ䛥䜜䚸䝍䞁䝟䜽㉁㛫䛻≉␗ⓗ䛺┦஫స⏝䛜ാ䛔䛶䛔䛺䛔䛣䛸䛜☜ㄆ䛥䜜䛯䚹䜎䛯䚸ᘬ䛝㞳䛧㐣⛬䛻䛚䛔䛶䛿䚸ྛ䚻

䛾䝍䞁䝟䜽㉁㛫䛷᥋╔ຊ䛜ほᐹ䛥䜜䚸䛭䛾኱䛝䛥䛿 wild type >> K97M > K97A 䛸䛺䜛䛣䛸䛜ศ䛛䛳䛯䚹㻌

䢳䢲䢲䢲䢺䢲䢲䢸䢲䢲䢶䢲䢲䢴䢲䢲䢲

䣘䣫䣵䣥䣱䣵䣫䣶䣻䢢䢪䣥䣒䢫

䢵䢲䢲䢲䢳䢲䢲䢲䢵䢲䢲䢴䢷䢲䢴䢲䢲䢳䢷䢲䢳䢲䢲䢷䢲

䢲䢢䣆䢢䢪䣰䣯䢫

ᅗ 㻠㻌⺯ගᑑ࿨ཬ䜃ඹ᣺䛪䜚 ᐃ䛛䜙ᚓ䜙䜜䛯㞼ẕ⾲㠃㛫䛻ᣳ䜎䜜䛯䜾䝸䝉䝸䞁⢓ᗘ䛾㊥㞳౫ Ꮡᛶ䚹

ᅗ 㻡㻌 ᾮయⷧ⭷䛾㼄 ⥺ᅇᢡ ᐃ䛾ヨᩱ㒊ᶍᘧᅗ䚹

ᅗ 㻢㻌㞼ẕ⾲㠃㛫䛾㻤㻯㻮㻌㻔ཌ䛥⣙ 㻞㻌㼚㼙㻕䛾䝷䝯䝷࿘ᮇ 䛾ᅇᢡ䝢䞊䜽䛾⤒᫬ኚ໬䚸㻔ୖ㻕㻌 ✚ศᙉᗘ䚸㻔ୗ㻕㻌 ༙

್ᖜ䚹㻌

59 研究活動報告

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61 研究活動報告

◊㻌✲㻌ά㻌ື㻌ሗ㻌࿌

䛆◊✲άືሗ࿌䛇 ࢚ࢿࣝࢠ࣮ࢹࣂ࢖ࢫ໬Ꮫ◊✲ศ㔝 ^㸦㹼㸧

ᩍ 㻌㻌㻌㻌 ᤵ 㸸ᮏ㛫᱁

ຓ 㻌㻌㻌㻌 ᩍ 㸸➚ᒃ㧗᫂Ᏹ᰿ᮏ⠜

⏘ ᐁ Ꮫ 㐃 ᦠ ◊ ✲ ဨ 㸸ఀ⸨Ύኴ㑻୕㇂ㅍ⩚⏕㞝Ẏ

- 6 3 6 ◊ ✲ ဨ 㸸ࢹࣂࣛࢪ࣒ࣕࢼ࢝ࢼࣁࣜࢣࣥࣃ࢖ࣖⓑᢎ᪫

ࣛࣥ࢞ࢵࣃࢹࢽࢵࢩ࣐ࣗࣛࣃࣥࢧࢸ࢕ࢵࢩࣗ

◊ ✲ ༠ ຊ ဨ 㸸᪂⏣▱༤

ಟኈㄢ⛬㸯ᖺ⏕ 㸸ᑠᕝ⚽அᕝཱྀ♸ྖ▮୰⨾⣖

Ꮫ 㒊㸲 ᖺ ⏕ 㸸⏣ᮧ┤㈗ᯇᑿ㝯⋞

ᙜ◊✲ศ㔝䛷䛿䠎䠍ୡ⣖䛾⛉Ꮫᢏ⾡䛜ྲྀ䜚⤌䜐᭱㔜せㄢ㢟䛷䛒䜛ᆅ⌫ᣢ⥆ᢏ⾡䞉ᚠ⎔ᆺ♫఍ᵓ⠏䛾Ⅽ䛻

෌⏕ྍ⬟䜶䝛䝹䜼䞊ᢏ⾡䛾䝣䝻䞁䝔䜱䜰㛤ᣅ䜢⾜䛖䠊㧗ᛶ⬟䜶䝛䝹䜼䞊䝕䝞䜲䝇䛾タィ䛸䛭䜜䜢ᐇ⌧䛩䜛㠉᪂

ⓗ䜶䝛䝹䜼䞊ᶵ⬟ᮦᩱ㛤Ⓨ䜢୰ᚰ䛻䠈ኴ㝧㟁ụ䠈⇞ᩱ㟁ụ䠈஧ḟ㟁ụ䛾㧗ᛶ⬟໬䜢㐍䜑䜛䛸䛸䜒䛻䠈䛣䜜䜙䛾㠉᪂ⓗ䜶䝛䝹䜼䞊ᢏ⾡䜢ᵓ⠏䛩䜛Ꮫ⾡ⓗᇶ┙䜢Ⓨಙ䛧䠈ᆅ⌫ ᬮ໬ᑐ⟇䛾䜲䝜䝧䞊䝅䝵䞁䜢ᘬ䛝㉳䛣䛩䛣䛸䜢

◊✲ᐊ䛾┠ᶆ䛸䛧䛶䛔䜛䠊

ᖹᡂ䠎䠎ᖺ䠐᭶䛻ከඖ◊䝃䝇䝔䝘䝤䝹⌮ᕤᏛ䝉䞁䝍䞊ᡤᒓ䛾◊✲ศ㔝䛸䛧䛶䝇䝍䞊䝖䛧䛯䜶䝛䝹䜼䞊䝕䝞䜲䝇

◊✲ศ㔝䛿ᖹᡂ䠎䠏ᖺ䠐᭶䛻䛿ィ䠓ྡ䛾䠦䠯䠬䠯◊✲ဨ䞉⏘ᐁᏛ㐃ᦠ◊✲ဨ䛜ຍ䜟䜚䠈㓄ᒓ䛾䠐ᖺ⏕䞉ಟኈㄢ⛬

Ꮫ⏕䛸ྜ䜟䛫䛶⥲ໃ䠍䠑ྡ䛾◊✲ᐊ䛸䛧䛶㡰ㄪ䛻◊✲άື䜢㛤ጞ䛧䛯䠊ෆ㛶ᗓ᭱ඛ➃◊✲㛤Ⓨ䝥䝻䝆䜵䜽䝖䜔

CREST

䝥䝻䝆䜵䜽䝖䛺䛹㔜せ䛺ᇶ♏◊✲㛤Ⓨ䝥䝻䝆䜵䜽䝖䛻ຍ䜟䜚䛺䛜䜙䠈᭱ඛ➃㟁ụ䝕䝞䜲䝇䛾◊✲㛤Ⓨ䛻

╔ᡭ䛧䛯䠊◊✲䝔䞊䝬䛸䛧䛶⌧ᅾ䠈ୡ⏺ⓗ䛺㛵ᚰ䛜㞟䜎䜚䛴䛴䛒䜛䝸䝏䜴䝮஧ḟ㟁ụ䠈኱ᐜ㔞䜻䝱䝟䝅䝍䠈⇞ᩱ

㟁ụ䠈ኴ㝧㟁ụ䛺䛹䛾䜶䝛䝹䜼䞊䝕䝞䜲䝇䜢ᥖ䛢䠈䛭䜜䜙䛾㧗ᛶ⬟໬䛸ᐇ⏝໬䛻㈨䛩䜛㠉᪂ⓗ䜶䝛䝹䜼䞊ᮦ

ᩱ䛸㧗ᛶ⬟䝕䝞䜲䝇タィ䛾ᇶ♏◊✲䜢䝇䝍䞊䝖䛥䛫䛯䠊䜾䝷䝣䜵䞁䛾㔞⏘໬䝥䝻䝉䝇䛾㛤Ⓨ䛸໬ྜ≀༙ᑟయኴ 㝧㟁ụᮦᩱ䛾

CuInSe2

⭷䛾㉸⮫⏺ὶయྜᡂ➼᭱ඛ➃䛾䝕䝞䜲䝇ᮦᩱ䛾䝥䝻䝉䝑䝅䞁䜾䛸᪂ᮦᩱ᥈⣴䜢⾜䛳䛶䛔䜛䠊

㸯㸬᪂つࣜࢳ࣒࢘࢖࢜ࣥᑟ㟁ᛶᅛయ㟁ゎ㉁ࡢ㛤Ⓨ࡜ࡑࡢ඲ᅛయࣜࢳ࣒࢘࢖࢜ࣥ㟁ụ࡬ࡢᛂ⏝

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67 研究活動報告

⎇㩷ⓥ㩷ᵴ㩷േ㩷ႎ㩷๔

䇼⎇ⓥᵴേႎ๔䇽 ࿕૕䉟䉥䊆䉪䉴䊶䊂䊋䉟䉴⎇ⓥಽ㊁

䋨2011䋮1䌾2011䋮12䋩

ドキュメント内研究業績・活動報告2011 (ページ 61-70)

㛵䜢ゎ᫂䛩䜛᪉ἲㄽ䜢☜❧䛩䜛䛣䛸䜢┠ᣦ䛧䛶䛔䜛 (ᅗ 5)䚹᫖

ᖺ䛿䚸ཌ䜏⣙ 2 nm 䛾䝇䝯䜽䝏䝑䜽ᾮᬗ 8CB 䛾 X ⥺ᅇᢡ ᐃ䜢

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㛫⤒㐣䛻క䛔䚸䝢䞊䜽ᙉᗘ䛾ῶᑡ䚸್༙ᖜቑ኱䜢ほ 䛩䜛䛣 䛸䛜䛷䛝䛯 ( ᅗ 6) 䚹䛣䜜䛿䚸⾲㠃䛾᥋㏆㐣⛬䛷ὶື㓄ྥ䛧䛯 8CB 䛾ᵓ㐀つ๎ᛶ䛜䚸᫬㛫⤒㐣䛻క䛳䛶⦆࿴䛧䛯䛣䛸䛻䜘䜛䛸

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⏕యෆ䛷䛿䝍䞁䝟䜽㉁䜔 DNA 䛸䛔䛳䛯⏕యศᏊྠኈ䛜┦

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䜈䛾ᙳ㡪䜢ホ౯䛧䛯䚹

䛭䛾⤖ᯝ䚸wild type 䛾䝸䝌䝏䞊䝮 - HyHEL10scFv 㛫䛷䛾䜏

≉␗ⓗ┦஫స⏝䛻㉳ᅉ䛩䜛ᘬຊ䛜ほᐹ䛥䜜䛯䚹 1 䜰䝭䝜㓟ኚ␗

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䛾䝍䞁䝟䜽㉁㛫䛷᥋╔ຊ䛜ほᐹ䛥䜜䚸䛭䛾኱䛝䛥䛿 wild type >> K97M > K97A 䛸䛺䜛䛣䛸䛜ศ䛛䛳䛯䚹㻌

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