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1. Improvement of higher brain dysfunction after brain injury by repetitive transcranial magnetic stimulation and intensive rehabilitation therapy: case report

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Department of Rehabilitation Medicine

Masahiro Abo, Professor and Chairperson Shu Watanabe, Professor

Kazushige Kobayashi, Professor Nobuyuki Sasaki, Associate Professor Itaru Takehara, Associate Professor Masanori Funakoshi, Associate Professor Toru Takekawa, Assistant Professor Kun Suk Chung, Assistant Professor Hidekazu Sugawara, Assistant Professor Anri Kamide, Assistant Professor Kouhei Miyamura, Assistant Professor

General Summary

The main research topics of our department are as follows: 1) effect of repetitive transcra- nial magnetic stimulation (rTMS), 2) treatment for stroke, 3) analysis based on database, 4) others.

Research Activities Effect of rTMS

1. Improvement of higher brain dysfunction after brain injury by repetitive transcranial magnetic stimulation and intensive rehabilitation therapy: case report

We have shown the safety and efficacy of rTMS therapy using a navigation system com- bined with intensive CR on two patients with cognitive dysfunction following brain injury. In addition, we observed changes in the areas around the rTMS target sites in brain imaging data.

2. The Efficacy of High

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Frequency Repetitive Transcranial Magnetic Stimulation for Improving Apathy in Chronic Stroke Patients

The application of high frequency rTMS over the dorsal anterior cingulate cortex (dACC) and medial prefrontal cortex (mPFC) may be a useful intervention for apathy due to stroke.

Treatment for stroke

1. Diffusion Tensor Imaging Evaluation of Neural Network Development in Patients Undergoing Therapeutic Repetitive Transcranial Magnetic Stimulation following Stroke Our findings indicate that the generalized fractional anisotropy (GFA) may have a poten- tially more useful ability than fractional anisotropy (FA) to detect changes in white matter structures in areas of fiber intersection for any such future investigations.

2. Effects of botulinum toxin A therapy and multidisciplinary rehabilitation on lower limb spasticity classified by spastic muscle echo intensity in post

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stroke patients

In conclusion, although patients with lower muscle echo intensity demonstrated improve- ments in motor function, the improvement was poor in those with higher muscle echo intensity.

3. Utility of the Revised Version of the Ability for Basic Movement Scale in Predicting Ambulation during Rehabilitation in Poststroke Patients

Our results suggest that the ABMS II score is a potentially useful tool to predict ambula-

Research Activities 2017 The Jikei University School of Medicine

東京慈恵会 医科大学電子署名者 : 東京慈恵会医科大学 DN : cn=東京慈恵会医科大学, o, ou, [email protected], c=JP 日付 : 2019.01.09 14:40:06 +09'00'

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tion during rehabilitation in poststroke patients.

4. Higher brain dysfunction

Cognitive and behavioral Sequelae in traffic victims. Greater gains, both physical and cognitive function, are made through long

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term support from comprehensive medical and social rehabilitation professionals.

5. Responsiveness of the functioning and disability parts of the International Classifica- tion of Functioning, Disability, and Health core sets in postacute stroke patients

Our results indicate that functioning and disability parts of these two ICF core sets can detect changes in functioning and disability in patients who receive an inpatient rehabili- tation program for postacute stroke.

Analysis based on database

1. Impact of orthotic therapy for improving motor ability in activities of daily living in individuals with spinal cord injury: a retrospective cohort study

Leg orthoses may improve activities of daily living in individuals with spinal cord injury after the acute phase.

2. Association Between 7 Days Per Week Rehabilitation and Functional Recovery of Patients With Acute Stroke: A Retrospective Cohort Study Based on the Japan Rehabilita- tion Database

Our cohort analysis demonstrated that 7d/wk of rehabilitation in early rehabilitation for patients with acute stroke can lead to functional recovery.

Others

1. Relationship Between Frequency of Spontaneous Swallowing and Salivary Substance P Level in Patients with Acute Stroke

In conclusion, the frequency of spontaneous swallowing was decreased in acute stroke patients with low salivary substance P (SP) levels. Salivary SP levels can be potentially a useful biomarker of risk of stroke

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associated pneumonia in the acute stage.

2. Nutritional supplementation for activities of daily living and functional ability of older people in residential facilities: A systematic review

Nutritional intervention with older people in residential facilities was effective in improv- ing handgrip strength, but did not significantly improve scores for activities of daily liv- ing, balance, gait velocity or preventing death.

Publications

Sasaki N, Hara T, Yamada N, Niimi M, Kakuda W, Abo M. The Efficacy of High-Frequency Repet- itive Transcranial Magnetic Stimulation for Improv- ing Apathy in Chronic Stroke Patients. European Neurology. 2017; 78: 28-32.

Hara T. Effects of botulinum toxin A therapy and multidisciplinary rehabilitation on upper and lower limb spasticity in post-stroke patients. Int J Neu- rosci. 2017; 127: 469-78.

Kinoshita S, Abo M, Okamoto T, Kakuda W, Miyamura K, Kimura I. Responsiveness of the

functioning and disability parts of the International Classification of Functioning, Disability, and Health core sets in postacute stroke patients. Int J Reha- bil Res. 2017; 40: 246-53.

Niimi M, Hashimoto, Hara T, Yamada N, Abo M, Fujigasaki H1, Ide T1 (1Tokyo Metropolitan Bokutoh Hosp). Relationship Between Frequency of Spontaneous Swallowing and Salivary Sub- stance P Level in Patients with Acute Stroke. Dys- phagia. 2018; 33: 414-8. Epub 2017 Nov 28.

Tsuboi M, Momosaki R, Vakili M1, Abo M Research Activities 2017 The Jikei University School of Medicine

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141

(1Ahvaz Jundishapur Univ, Ahvaz, Iran). Nutri- tional supplementation for activities of daily living and functional ability of older people in residential facilities: A systematic review. Geriatr Gerontol Int.

2018; 18: 197-210. Epub 2017 Aug 31.

Hada T, Momosaki R, Abo M. Impact of orthotic therapy for improving activities of daily living in indi- viduals with spinal cord injury: a retrospective cohort study. Spine & Spinal Cord. 2018; 88-9.

Hara T, Abo M, Hara H1, Kobayashi K, Shima- moto Y1, Shibata Y1, Sasaki N, Yamada N, Niimi M (1Kikyougahara Hosp). Effects of botuli- num toxin A therapy and multidisciplinary rehabili- tation on lower limb spasticity classified by spastic muscle echo intensity in post-stroke patients. Int J Neurosci. 2018; 128: 412-20.

Kinoshita S, Momosaki R, Kakuda W, Oka- moto T, Abo M. Association Between 7 Days Per

Week Rehabilitation and Functional Recovery of Patients With Acute Stroke: A Retrospective Cohort Study Based on the Japan Rehabilitation Database. Arch Phys Med Rehabil. 2017; 98:

701-6.

Kinoshita S, Abo M, Okamoto T, Tanaka N.

Utility of the Revised Version of the Ability for Basic Movement Scale in Predicting Ambulation during Rehabilitation in Poststroke Patients. J Stroke Cerebrovasc Dis. 2017; 26: 1663-9.

Yamada N, Ueda R1, Kakuda W, Momosaki R, Kondo T2, Hada T, Sasaki N, Hara T, Senoo A1, Abo M (1Tokyo Metropolitan Univ, 2Shimizu Hosp). Diffusion Tensor Imaging Evaluation of Neural Network Development in Patients Undergo- ing Therapeutic Repetitive Transcranial Magnetic Stimulation following Stroke. Neural Plasticity.

2018; 3901016.

Research Activities 2017 The Jikei University School of Medicine

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