Title
脂質過酸化反応におけるアルデヒド生成物とビタミンEの
作用に関する研究( 内容の要旨(Summary) )
Author(s)
斉藤, 史恵
Report No.(Doctoral
Degree)
博士(農学) 甲第553号
Issue Date
2010-09-10
Type
博士論文
Version
none
URL
http://hdl.handle.net/20.500.12099/36635
※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。fE fS (i (B"fE) JB3? Lk a) * # * Ik ie * % JB+IkhnJ5*,q P J*ijlli 32 ji. a) i I* WgE*S4 &tJ: *4t
mgEfB# i:52 61 T= jcJt23i+ jBi- Ik -Ea I Rg E] * af 4i a i: a B* B! .75, (5ah]A) i*j= (B%jB3?) Bti*P# 553 % 5FBE22*9,q 10 EI JB+lkRRu# 3 A# 1 4ii%j i*%Bt JB+m gErS[ 4i4h fW,*1 JB3?*4t u&J>jc JB3?
BB5fia&1t:LiFS8=3b- 818 7)I,fh I= fi>4=Bk4hi tf'5 -I
y E a)1fj7]8=Lq-f8qgE j=i d*jaj(JB3? li#]* 6[ji d&j>j(jBj? a ]2 6rji #Rqj(JB3? ##32 jE 2F JB i Lu Pq i fq % i i ;a 3E 0) F∼ * 0) f a
*JB3#iLib5altj:,BE5fiE=yj(&Bk4hvchb 8 a , B -7=f&fD7}Vj=h-t= fit-a)&FSJr&8=35B L,
T, BB#i&@1bLiFS8=h'ila7/I,TJ>t= f<%Bk4ho)ifjf] i: ttt19-Iy E i 8#iajiFSk*#
L, BtbEiFETJr&e)#V '4-** y-2-) jT,+-JL, (ONE) 8=i
8BE5fi&*1t:1jE5Slfjqi ry
-T.=7=D-/I, (y -TH) 8=i8#&iMk-3U'TPA 6b,B= LT=be)TChb8o *mgE7fh4%
6nT=fp3iEj:i;RTn ijab9 rChb8o
BaiBt&ct,a -q=f&*D7/i,jet T<1'G3:BB#q)8=&Bk+8 I i A,6, %e)%0)BE#ib8=#
LTIq6bl,n,#g?k&821g#TWbao i I -Ch, *jBj#5Ee&I-e,8j:,W -/V#} 91}v (MeL) q)a #*1kfiFS8=#+8%#7}t,j:I t= T{Io)1fjq8=J3U IT, *51bS4itfbnf=. %o),J#A, ONE tj:MeL E]E:%%L< LEL#giU=bS, 4- t= f<1tT=*->-2-)jT,+-JV%
IhQ)&*P7JL,flt T<1/++-Jt,, *9 5+-/v, J1*++-}L,) kR MeL e)B&@
1t:t=#LTE2t AJZfh#gkjikt}v1= tbSWWh5hT=. 5 E)8=, ONE a) E]#*1k1&5glf
B]8=J3V'Tb, *54bS11tfbhTlo 3:-f, Pg7EJr&t=TIt=<}t,**.> T< (LOOH) t5SW2? &RSj*>k MeL A,6*jf LT, MeL E]#@1b8="a ONE 0)5ilaAb1;{JgJ<6hf=o I
a)jW, ONE iBi&Thti MeL a) E]bt3:1&ig 5 YLi!, BB.W56JrW#f*TChb 8 Fe(I)-ju 0)jgf8=i:J3TibbT#1bblS1&ig5na I i:bSPA E)A,8=+?-3T=o i;RtO)#Ab,6, ONE
a)BE5i@*1btE3glfR EiL*]g4>B;JI *>kAt Lf= b OT>b 8 I i bS,j%5nT=. 3:f=*m3*n
8=iblUITrL ONE tj:Fe3+ ki5jtLT Fe2' i+8= tbSTCh%, Lb,b4=BkLf= Fee+ Gj:
ONE tBE*4&o)#6Sklf3BEi-a I i ASPA 6b,8=+fJ37:-Lo iCJ3T, ONE 83:BB5fEF]o)LSW2?
4iBSJ1 *yki5jt#i!t= LT*#klE3Bk L, fe)#Bt& t=f=-ONE-3%jtni9&RS*i*bSBB#i& #1E:Bqibe)BEg i tJ:8 7 U -7.}*}L,4iBki=Bgb8 b i a)#iErbbStf 5hf=o
-21-lj:8=,fiFSJr*0)%b#u ' ONE
i tt1'g-I> E i 0)jiFS8=-?U'T*=HbS41{3:btLf=. A i*B#B#8=Gj:bSBE*Jhtbt#1b#u i L,T TH bitiSn LTU ,a a)Th, 4=1SBSPT4Bk 5hf=
a ,B -q=eEz*p7)i,f∼'t=T<1tj:TH 8=i: -3T#iAghaq%EJr&bS5%k 6YL8 bS, %o)jiFS,r&i=
-?U'rCtiq=PAThbJ3f=o Lf=bSJ3Tt *mgETlj:, ONE i TH tD&FSbS*515hf=. A1SB9i=fj:, ONE %7i= T,I T,U/i,8=*AILi*7nf 37o C TTH t&FS5iff=t
=b, y
-e 6 -TH FiONE tjiFSL, HPLC
J<DiiF8=iJ3TiiFS4=Bk4htto-9bS*tB5 31f=o %=TC., y -TH i ONE te)jiFS&Bk4h8=-3V'T, JtDiEkWLC 8=iJ3TEiFE4=Bk
qh 1-3 bS5ii&Sn, 1E%4h 1-3 &i$3SAWbS11tfbnT=,#j%, U,-i2nb v -TH a) 5 liz 8= ONE ∼ 5 15ZbS,Jd%LT= bD75SiE#^5hT=o 3:f=, %o)fEBk*1#t3:, ONE bS#e)i+n f7?+3F)i%L,T75iy#q'FRq1*t ff 9
, =ilbS y -TH 0) 5 L5fL=*%LTlb%4h 1 i 7ba i
n7fhb 9, 5 68=&FSDigFt i b8=Bg##iEe)1E:%4h 2Jlt/2glbL,, 2 8=b 5 1 JZDi+∼ ONE AS,#%LTlb%4b 3 8=i2a I tbS,j%5hf=o =h6D&FS4=Bk4btj:, MeL 8=ONE
i y -TH kV5gi),L,T#r&) >BE##AfTRFSg%f=Ba%8=b#h-Ch%T== tb,6, v
-TH 8=i 8 ONE f6iREiFS8j:BB#*ThbkE= 8 bD t5%i 6YtJao
*WRTIL BB5fiA*1kLiFS-c4 t=f= ONE E3:8&&n3Sr4BSJ/ *yklr LTBB5Ei&%u lE:k5 68=1&L#+8= tbSi9]bTPB 6b,8=5nf=o 3:f=, Jy-TH 8j:%nbt*1Elfjn=ct
J3T ONE 0)4=BEi:UnSrJTh% 8 bS, 1-C1=W L,f= ONE 8=#L,Tb =YLk#iA LTq=fE %1bTCh%8 I i bPA 6A,8=5ILT=o
* 2E a BS 0) f B
**Ikj&2G3:, hB#i&E*1t:=R4=Bk4hvCh A 8 a,P-q=&*P7/I,fh 1= T{-n&ESig:t=3P EI L T, BE5Ei&&1t:EiFSt=h'8187/I,fh't= Tih&BR4bDlfjq i tfh5 i y E i:a#fA&TS&*51
L,, &bLiFSJBe)#u' 4-**y-2-/%,+-)V (ONE) 8=i aBE5fit:LRigfFR]
ty-h=7=D-)I, (y-TH) t=ia#ki*#k-3t'TPB 6b,L=Lf=bQ)7)b8. *qgETh1$
6TLT=bAt3:J2iLTe) i ja19 7fhb 8.
#fbi*Q,P-q=f&*7/I,f' t= fIE3:BB5f*8=fEBki-a I i b16, %e)%nBE5Eia&1t:8=# LTIq6ble),%g?kBt8=h+g#?t3Jr*bSb8o %=Tk, U /-}L,#}51}t, (MeL) DB&# 1E&FS8=#+84>@7Jt,TJ-t= TIOlfj7] k*idLf=o %o)#A, i&b#V,&FE:4&k#+a
ONE Sj:MeL E]Ek% L,< l&igSitT=bS, 4-t= rlt=*->-2-/jT,+-}t,JPlhe)&*p7
}t,TJ-t= Tin()++-}L,, *95+-}t,, -*9-+-)t') 8=$3:, MeL DB##4bt=#L
T82t AJ2fh^jaafgPkSk+fb,-Df=o %=7f>, ONE a) B&*1E1&iglfj!]k 5 68=iS#P8=* !JLf=. 3:ii, PqriJBt: T<1T=J<)V**.> fI (LOOH) t5SW2?@RS-I *>k*iiLT=
MeL kWALT ONE Q),ijA&aqJ<flo =Q)%%, ONE *i&TliMeL ∼ B#@1b8i LAig S h,f, BE*f4!aRS%[iTChb 8 Fe(m)-ju DjtG=f8= i:J3 Ti5bT#1bbSIRig 5 hJf=.
i;Aio)#Btb, 6, ONE 0)BB5fi&*1btBiglfjf] Gj:5S#2?&RSJ1 *J&* Lf= b 0)rob a I
i bib,j%5hf=. -Ax'hi=, i55f;1FB!e)5S#:p,&BSJ{*ytiJEDi+### t&FS+8 i , t= TI-tt*
・>}t,7-}*}t,k4=Bk5itao 4 3:f=, &FST#t=#7E+a/i&&o) LOOH Q3:, i*#@Bij *
y8=ilT I/ t<'.y9 AJ<DiA2'q:k2U, 7)I,= *,J/i,7.}*/i,%J<}L,**->}t,9 -}*/I,k4=
BkSit8. *q#E8=ib'U,T, ONE t3: Fe3' ki2jtL,T Fez. i+a= tbS7fh%, Lb,b4=
BELf= Fez. E3= ONE tBE#'i*e)#i*k#3Bk-Ch% flo ^iE-,T, ONE 8j:BE5fEPo)5S#@R%
-22-/*>ki55tni!LT@%tik#3BEL,, %n#Bt4=t=f= ONE-i2jtnj@BS#i*bSBE#i&*4t:Ba f5
q)LET,Attfa79 -7-}*/I,4=Bkkrqb8b ∼t#jEriLf=o
R8=, EiFSf&n&b#V1 ONE i tt1'5-Iy E tDLiFS8=-?V'T*5d.Lf=o 4=#BSBE5f t=EibSBE*JBbt&1b#IJ i LT TH bS## LTVlaO)Th, 4=t*E*q'Th&BEghf=cL,P-q=eB fp7}L,f-t= rlii TH t=i-3T#&ShagSEi*bS5%k 6h8bS, %o)EiFSt&8=1UITEi
*]:thTPAT.ba. ONE k7* h= h 9)V8=*blLi*rf7Ef arc TChTH tiiFSg%f=
i =b, y. e 8-TH Ei ONE t&FSL, HPLC JZDiiF8=iJ3T&FS&Bk4btto-9bS4*tH
Snf=. %=vc., y-TH i ONE tnjiFS4=BE4b8=-?V'T, LAiEkHPLC 8=i:J3T&FS4i hkgb 1-3 kLAi#Lf=. 1t:%4h 1-3 %#L%A*8fLf=t =8. V'filby-TH 0) 5 1k8= ONE n 5 J51bS,#% LT=bO)-ChbJ?T=. 3:f=, %q)&Bk*#tj:, ONE i)S#e)rf#TTChBF]
i%LT75iyfRq'Fpql*t7b 9, =hbSy-TH ∼ 5 Jii=*%L,Tlb%4b 1 t*fabe)Tkb 9, 56C=LiFtT,0)ig4it i b8=Bf3##iEDlt:%qh 2 I.t-t#1bL, 2 t=b5 1 JEDi+o) ONE bikJ#%LTIE:%4h 3 8=*f8 I tb;,j%5atf=o =h6e)LiFS4=BkqhEj:, MeL 8= ONE i y-TH &*b,LT#i* U >BE5frf#TvChEiFS5itT=%%8=b*-#hTh%T== i b'
6, y-TH i=J:a ONEt#iE&FStinE#*vChb&=abOt5%k6hflo
*qgE8= i -3T, BE#it:LiFSToiCT= ONE 8i8&&e)5S#&RU *Ji:AL LTEB
#iA&1t:k 5 6i=1XEig L, ,
-i, y-TH 8i%q)bt*1t:1fiF]t=iJ3T ONE a)4=Bkk3q&JTh
58bS, i-T1=4=BkLT= ONE 8=kLTb=YLk#iBLTq=ffJr%1bT.5 8 I i %P^ 6bl
t=Lf=o
i;Rtq)ali=-?V 'T 8=J3V'-CC*B;8=*# L,f=,*A, 4$ 6hf=*DR.tj:JB3?Wgbb8=#15 a)b8 b a) i *fJW ShJf=. %0)#5B, %Z&*A4iA-&Th*-i&IbSd&jijc*jc*Rj;
Lf%B%*WgE*4o)I?[iii&X i LT+J<Di6nqLB.A a b D i %bT=.
&#t t3:8*ai=&Xf3:J2XTe) i iS 9 Thb8.
1.Saito,F., Iwamoto, S. & Yamauchi, R.: Reaction products of y-tocopherol with (E)-4-oxo-2-nonenal in acidic acetonitrile. Biosci. Biotechnol. Biochem., 74(I),168-1 74 (2010).
2. Saito, F., Iwamoto, S. & Yamauchi, R.: 4-Oxo-2-nonenal as a pro-oxidant during the autoxidation of methyl linoleate in bulk phase. Food Chemistry, in press.