つくばリポジトリ PTCOG49 print

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Devel opment of mul t i pl e r egi ons t r acki ng syst em t o r educe i nt er and i nt r a- f r act i onal er r or f or pr ot on t her apy 著者 内容記述 URL TERUNUMA Toshi yuki ,SAKAE T. I SHI DA M. SATO M. I KUMI S. YASUOKA K. KUMADA H. OKUMURA Toshi yuki ,TSUBOI K. SAKURAI Hi deyuki PTCOG49 -49t h Annual Meet i ng of t he Par t i cl e Ther apy Co- Oper at i ve Gr oup Sci ent i f i c Meet i ng, 2010 Thi s i s t o cer t i f i cat e of t he Out st andi ng Post er Awar d of t he 49t h Annual Meet i ng of t he Par t i cl e Ther apy Co- Oper at i ve Gr oup, Sci ent i f i c Meet i ng, 2010. Cat egor y: Physi cs, 5/ 21/ 2010) ht t p: hdl .handl e. net /2241/ 00146113 Development of multiple regions tracking system PTCOG49 to reduce inter and intra-fractional error for proton therapy T. Terunuma, T. Sakae, M. Ishida, M. Sato, S. Ikumi, K. Yasuoka, H. Kumada, T. Okumura, K. Tsuboi and H. Sakurai Proton Medical Research Center (PMRC),University of Tsukuba, 1-1-1 Ten-nohdai, Tsukuba 305-8575, Japan E-mail :terunuma@pmrc.tsukuba.ac.jp 1. Introduction 5. Performace of pattern matching Is the irradiation accuracy enough when the tumor is just at the uncertainty. Both positions of the structure on the beam path and the tumor should be checked during patient setup and treatment to reduce inter and intra-fractional irradiation error. The aim of this work is to respiratory bony proton structure beam study the possibility of moving tumor Processing Time for 1 template pattern matching (msec )tumor is also important, because the positional uncertainty of this structure on the proton beam path causes the proton range s Tumor Relation between the processing time of pattern matching and the template image size isocenter ?The position of a high-density structure in front of the 7. Analysis of traking error 25 20 15 10 5 0 0 64 128 192 256 320 384 448 512 Side Length of Square Template Image (Pixel )multiple regions tracking. blue circle &red circle show the result of searching within full-area and within the template image size +30mm margin. 2. Concept Processing time of multiple pattern matching Bony sructure 45 A X-ray device which can be rotated with a proton gantry is an Processing Time (msec )40 appropriate arrange of the system to check both positions of the structure and the tumor. In this case, the X-ray direction is perpendicular to the proton beam direction. Therefore the X-ray projects the tumor and the structure, which is on the proton beam path, on an imaging device. 35 30 25 20 15 10 5 proton beam 0 X-ray tube nozzle 1 2 3 4 5 Nombers of template image 6 7 Up to 5 regions tracking are performed within the time interval of patient fluoroscopic image acquisition (33 msec )6. Result of multiple tracking I.I. or FPD gantry Lung red: target green: rib on beam path 3. System In upper distribution maps, grren line shows the standard deviation of the positional errors for each tracking score which is normalized by 1000. Fluoroscopic Images acquired during setup for 10 patients (5 lung cancer and 5 liver cancer )were analyzed. Tracking error (1sigma) of tumor and that of boney structure are 4.06 pixel and 0.38 pixel, and those are equivalent to 1.8 mm and 0.11 mm. The developed real-time tracking system utilizes a fluoroscopic X-ray image and a patient s respiratory waveform. The resolution of projected image around the isocenter is 0.3 mm/pixel. The position of 8. Discussion tumor and the structure on the beam path are calculated by a pattern matching algorithm. The calculation time of pattern matching depends on the tamplate image size and the serching area. For typical size of template image, 5 regions tracking are performed in real-time. X-ray tube unit Liver Proton beam Proton accelerator red: a part of target Laser displacement sensor green: I.I. rib on beam path Beam ext. cntl. Internal information External information Frame graber Position Display &Record Judgement Threfore lower correration score of the tumor between the fluoroscopy and the template image are calculated when inhale phase, because the template image are obtained in exhale phase. A multiple region tracking is enough whthin exhale phase. A biplane X-ray system, one imaging device of which is inserted in Respiration Phase +Serching Tumor Positon Tumor tumor is more deformed with respiration than the bony structure. shows the existance of lower correlation. However, the accuracy of 30 frams /s )Output Irradiation Gate structure come from the difference of the elasticity of objects. The wide distribution of the pattern matching score of tumor tracking Process within PC ADC/DIO The difference of tracking error between the tumor and the bony the beam direction, is used for patient 3D registration. In this Template image form DRR or DR precedure, the multiple regions tracking is effective to determine the by Pattern Matching tumor position and the structure position on the beam path. Thus this function can reduce the inter-fractional irradiation error. During treatment, it is difficult to monitor object s accurate 3D position, because no imaging device can insert in the beam line and 4. Pattern matching algorithm arrangement of biplane X-ray system in gantry is difficult. The tumor mainly moves in S-I direction and the bony structure such as rib The developed pattern matching algorithm is based on searching a moves exterior due to lung infration. Therefore a single-plane X-ray maximum position of the score which is calculated by using the system perpendicular to the beam direction can check the positional normalized cross-correlation between the fluoroscopic image and the diference between the patient 3D registration and the treatment. template image. This algorithm can calculate the position in sub-pixel Thus this function can reduce the intra-fractional irradiation error. 1/10) resolution, and can correspond to image changing in rotation (5 degree) and in expansion (10%)9. Conclusion The function of the real-time multiple regions tracking was L 1 K 1 w(x, y) w)(f (x +i, y; j) S (i, j) f (i, j))x= 0 y= 0 1 2 L 1 K 1 L 1 K 1 w(x, y) w) 2 x= 0 y= 0 1 2 f (x +i, y; j) x= 0 y= 0 f (i, j))2 A example of tracking is shown. The image acquired during patient setup is used developed. The possibility to check the positional uncertainty of the in this example. White line is respiration wave, green line and dashed line are the tumor and the structure on the proton beam path is shown. Thus the pattern matching scores of the tumor and the rib, red line and blue line are the inter and intra-fractional irradiation error can be reduced by using this trajectories of tumor in S-I direction and L-R direction, and red dashed line and blue dashed line are the trajectories of rib in S-I direction and L-R direction. system.

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