Comparison of disintegration profiles of rapidly disintegrating tablets containing famotidine

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㩷 ^㧙㪈㧙

原著論  㩷

ファモチジン含有速崩壊性錠剤の崩壊性の  較 㩷

㩷

᧛ጊାᶈ㧘⥱↰⹞ᱠሶ㧘ศ↰ᙗ๺㧘ୖ↰ߥ߅ߺ㧘ਛ᧛᣿ᒄ㩷

ᤘ๺ᄢቇ⮎ቇㇱ⮎೷ቇᢎቶ㩷 㩷

ⷐ ᣦ㩷

ㄭᐕ㧘ᧄ㇌ߦ߅޿ߡᄙߊ਄Ꮢߐࠇߡ޿ࠆㅦ፣უᕈ㍤೷ߪ㧘ฦ␠⁛⥄ߩ⵾ᴺߢ⵾ㅧߐࠇߡ߅ࠅ㧘 ߘߩ፣უᤨ㑆߿፣უㆊ⒟ߪ⇣ߥߞߡ޿ࠆ㧚㩷

ᧄ⎇ⓥߢߪ㧘ࡈࠔࡕ࠴ࠫࡦ฽᦭ߩㅦ፣უᕈ㍤೷㧘㪍⒳ߦߟ޿ߡ㧘ໜᶧߩߺߢ᦯↪ߣ᳓ߢ᦯↪ߔࠆ ߎߣࠍᗐቯߒߚ᧦ઙߢ㧘፣უ․ᕈࠍᲧセᬌ⸛ߒߚ㧚޿ߕࠇߩ᧦ઙਅߢ߽ㅦ߿߆ߦ፣უߔࠆ⵾೷㧘

᳓ߩዋߥ޿᧦ઙ߿ૐ⩄㊀ߩ᧦ઙߢ፣უߦᤨ㑆߇߆߆ࠆ⵾೷ߥߤ㧘፣უ․ᕈߪ⵾೷㑆ߢᄢ߈ߊ⇣ߥ ࠅ㧘ߎߩ㆑޿ߪ⵾ᴺ߿ᷝട‛ߦࠃࠆ߽ߩߣ⠨߃ࠄࠇߚ㧚ฦ⵾೷ߩ፣უ․ᕈߩ㆑޿ߪ᦯↪ߒ߿ߔߐ

߿቟ోᕈߦᓇ㗀ߒ㧘᦯↪ߒ߿ߔ޿⵾೷ߩㆬᛯ߇᦯⮎ࠦࡦࡊ࡜ࠗࠕࡦࠬߩะ਄ߦ⽸₂ߔࠆ߽ߩߣ⠨

߃ࠄࠇࠆ㧚㩷 㩷

㪢㪼㫐㩷㪮㫆㫉㪻㫊㧦Ḩ⵾㍤㪃㩷ญ⣧ౝ፣უ㍤㧘ㅦ፣უᕈ㍤೷㧘፣უ⹜㛎㪃㩷ࠫࠚࡀ࡝࠶ࠢක⮎ຠ㩷

㩷

✜ ⸒

ญ⣧ౝ፣უ㍤߿᥉ㅢ㍤ߢ޽ߞߡ߽፣უ߇ㅦ޿

㍤೷㧔ᧄႎߢߪ౒ߦޟㅦ፣უᕈ㍤೷ޠߣ๭߱㧕ߪ㧘 ญ⣧ౝߢㅦ߿߆ߦ፣უߒ㧘㜞㦂⠪߿ዊఽߥߤ㧘ㅢ Ᏹߩ㍤೷ࠍ᦯↪ߔࠆߩ߇࿎㔍ߥᖚ⠪ߢ߽ኈᤃߦ

᦯↪ߒ߿ߔ޿೷ᒻߢ޽ࠅ㧘ㄭᐕ㧘ᄙߊߩක⮎ຠߢ 㐿⊒㧘਄Ꮢߐࠇߡ޿ࠆ㧚㧔․ߦ㧘ญ⣧ౝ፣უ㍤ߪ ໜᶧߩߺߢ᦯↪ߔࠆߎߣ߇ߢ߈㧘ᚑੱߦ߅޿ߡ߽

᦯↪߇ଢ೑ߥ⵾೷ߣߒߡ೑↪ߐࠇߡ޿ࠆ㧚㧕㩷 ߒ߆ߒߥ߇ࠄ㧘ታ㓙ߦߪ㧘ᄙ೷ࠍ૬↪ߔࠆ႐ว ߇ᄙ޿ߎߣ߆ࠄ㧘ㅦ፣უᕈ㍤೷ߪઁߩ᥉ㅢ㍤ߣ౒

ߦ᳓ߢ᦯↪ߐࠇࠆࠤ࡯ࠬ߇ᄙ޿ߎߣ߇ႎ๔ߐࠇ ߡ޿ࠆ^㪈㪃㪉㪀㧚ߎߩߚ߼ක≮⃻႐ߢߪ㧘᦯↪ߔࠆⶄᢙ

㍤ਛߦญ⣧ౝ፣უ㍤߇౉ߞߡ޿ߡ߽⥃ᐥ⊛ߦߪ

޽߹ࠅᗧ๧߇ߥ޿ߣ⠨߃ࠆ௑ะߦ޽ߞߚ㧚ߎࠇߪ㧘 ญ⣧ౝ፣უ㍤ߪໜᶧߩߺߢ᦯⮎ߔࠆߎߣߦଔ୯ ߇޽ࠆߣ޿߁వ౉ⷰ߆ࠄ↢߹ࠇߚ⹺⼂ߢߪߥ޿

߆ߣ⠨߃ࠄࠇࠆ㧚ߘߎߢ㧘ᚒޘߪ㧘᳓ߢ㪉೷ࠍ᦯

↪ߔࠆ㓙㧘㪉೷ߣ߽᥉ㅢ㍤ߩ႐วߣ㧘 ᣇ߇ㅦ፣

უᕈ㍤೷ߢ޽ࠆ႐วࠍᲧセߒߚ⚿ᨐ㧘ᓟ⠪ߩᣇ߇

⋧ኻ⊛ߦ᦯↪ᕈ߇ะ਄ߔࠆߎߣࠍႎ๔ߒߡ߅ࠅ^㪊㪀㧘 ߐࠄߦ㧘ߎߩᬌ⸛ߦ߅޿ߡߪ㧘ࠃࠅㅦߊ፣უߔࠆ ㅦ፣უᕈ㍤೷ߢ޽ࠆᣇ߇㧘᦯↪ᕈ߇ࠃࠅะ਄ߔࠆ ߎߣ߽⏕⹺ߒߚ㧚ߎߩߎߣ߆ࠄ㧘ⶄᢙ㍤ߦ฽߹ࠇ ࠆㅦ፣უᕈ㍤೷ߪ᦯↪ᕈߦ߅޿ߡࡔ࡝࠶࠻߇޽

ࠆߣ⠨߃ࠄࠇࠆ㧚㩷

ㄭᐕ㧘ࠫࠚࡀ࡝࠶ࠢක⮎ຠߩផㅴߦ઻޿㧘ਥ⮎㧘 ⷙᩰ߇หߓ⵾೷߇ᄙߊ਄Ꮢߐࠇߡ޿ࠆޕ↢‛ቇ⊛

ห╬ᕈ߇⏕଻ߐࠇߚ⵾೷ߢ޽ߞߡ߽㧘᦯↪ᕈߩ⇣

ߥࠆ⵾೷ߪ⥃ᐥߦ߅޿ߡᄙߊ⷗ࠄࠇࠆ㧚ߥߗߥࠄ㧘 ㅦ፣უᕈ㍤೷ߪ㧘ฦ␠⁛⥄ߩ⵾ᴺߢ⵾ㅧߐࠇߡ߅ ࠅ㧘ߘߩ፣უߩ઀ᣇ߽⇣ߥߞߡ޿ࠆߚ߼ߣ⠨߃ࠄ ࠇࠆ㧚㩷

Ⴧ↰^㪋㪀ಽ㘃ߦࠃࠆߣ㧘ญ⣧ౝ፣უ㍤ߩᛛⴚࠦࡦ

࠮ࡊ࠻ߪ㧘㍌ဳ㍤㧘Ḩ⵾㍤㧘৻⥸㍤ဳߦಽߌࠄࠇ

― 150 ―

㩷 ^㧙㪉㧙

ࠆ㧚৻⥸㍤ဳߪߐࠄߦᄙሹ⾰ᒻᚑ૕⵾೷㧘፣უᯏ

᭴Ꮏᄦ⵾೷෸߮ᤃᚑᒻᕈᷝട೷૶↪⵾೷ߩ㪊⒳㘃 ߦಽ㘃ߐࠇ㧚ࠟࠬ࠲࡯㩷㧰㍤ߪᄙሹ⾰ᒻᚑ૕⵾೷㧘

ࠟࠬࡐ࡯࠻㩷㧰㍤㧘ࡈࠔࡕࠬ࠲ࠫࡦ㩷 㧰㍤߅ࠃ߮ࡈ ࠔࡕ࠴ࠫࡦ㧰㍤ޟࠨࡢࠗޠߪ፣უᯏ᭴Ꮏᄦ⵾೷ߦ ዻߔࠆߣ⠨߃ࠄࠇࠆ㧚ࡉࡠࠬ࠲࡯㩷 㧹㍤߅ࠃ߮ࡈ ࠔࡕ࠴ࠫࡦ㧰㍤ޟ㪜㪤㪜㪚ޠߪḨ⵾㍤ߢ޽ࠆ߇㧘೨

⠪ߪㅦ፣უᕈߩ᥉ㅢ㍤㧘ᓟ⠪ߪญ⣧ౝ፣უ㍤ߢ޽

ࠆ㧚㩷

߹ߚ㧘ญ⣧ౝ፣უ㍤ߩၮᧄᕈ⢻ߦၮߠߊ೎ߩᛛ ⴚಽ㘃ߣߒߡ㧘╙৻߆ࠄ╙ਃ਎ઍ^㪌㪃㪍㪀ߦ඙ಽߐࠇࠆ ߎߣ߽޽ࠆ㧚ߚߛߒ㧘ߎߩ਎ઍಽ㘃ߪ㧘᛫ࡅࠬ࠲

ࡒࡦ⮎ߩࠃ߁ߦᛛⴚㅴᱠࠍ⴫ߒߚಽ㘃ߢߪߥ޿㧚 ㅦ፣უᕈ㍤೷ߪవ⊒㧘ᓟ⊒ฦ␠ߩ․ᓽߩ޽ࠆ⵾೷

⸳⸘࡮⵾ㅧᛛⴚߢ⵾ຠ㐿⊒ߐࠇߡ߅ࠅ㧘ߘࠇߙࠇ ߦ㐳ᚲ࡮⍴ᚲ߇޽ࠆߎߣߦᵈᗧ߇ᔅⷐߢ޽ࠆ㧚଀

߃߫㧘╙৻਎ઍߣߐࠇࠆ㪱㫐㪻㫀㫊^㪎㪀ᛛⴚߪ㧘ઁߩᛛⴚ ߢ⵾ㅧߒߚㅦ፣უᕈ㍤೷ࠃࠅ࿶ୟ⊛ߦㅦ޿፣უ ᕈࠍ␜ߒ㧘᰷☨ߢߪ৻⥸⊛ߥญ⣧ౝ፣უ㍤ߣߒߡ ฃߌ౉ࠇࠄࠇߡ޿ࠆ߇㧘⣀޿ᕈ⾰ߩߚ߼৻൮ൻߢ ߈ߥ޿ߎߣ߇ᰳὐߢ޽ࠆ㧚╙ੑ਎ઍߪ㧘Ḩᑼ෶ߪ

ੇᑼߢૐ࿶ᚑᒻߒߡᄙሹᕈࠍઃਈߒߚᓟ㧘ੇ῎╬

ߩᓟಣℂߢᒝᐲࠍઃਈߔࠆᛛⴚߢ޽ࠆ㧚ࡈࠔࡕ࠴

ࠫࡦ㧰㍤ޟ㪜㪤㪜㪚ޠ߅ࠃ߮ࡉࡠࠬ࠲࡯㩷 㧹㍤ߥߤߩ 㪜㪤㪧 ㅦ፣㍤^㪏㪀߇⹥ᒰߔࠆ㧚╙ਃ਎ઍߪ㧘ᤃᚑᒻᕈ ߩᷝട೷߿፣უ೷ߩㆬᛯ߿ಣℂߦ․ᓽࠍ᦭ߒ㧘ㅢ Ᏹߩ㍤೷ߣోߊหߓ⵾ㅧᣇᴺߢ⵾ㅧߔࠆᛛⴚߢ

޽ࠆߚ߼ੇᑼ㧻㧰㍤ߣ⸒ࠊࠇࠆߎߣ߽޽ࠅ㧘ࠟࠬ

ࡐ࡯࠻㩷 㧰㍤㧘ࡈࠔࡕࠬ࠲ࠫࡦ㩷㧰㍤߅ࠃ߮ࡈࠔࡕ

࠴ࠫࡦ㧰㍤ޟࠨࡢࠗޠ߇⹥ᒰߔࠆ㧚ࠟࠬ࠲࡯㩷 㧰

㍤ߩ㪮㪦㪮㪫㪘㪙㪄㪛㪩㪰ߪ㧘╙ੑ਎ઍߦಽ㘃ߐࠇࠆߎ ߣ߽޽ࠆ߇㧘╙ਃ਎ઍ^㪐㪀ߣߐࠇࠆߎߣ߽޽ࠅ㧘ਛ 㑆⊛ᛛⴚߢ޽ࠈ߁㧚㩷

㍤೷߇ߤߩࠃ߁ߦ፣უߔࠆ߆ߪ㧘ᖚ⠪߇㍤೷ࠍ

᦯↪ߔࠆ㓙ߩ㊀ⷐߥⷐ⚛ߢ޽ࠆ㧚ㅦ፣უᕈ㍤೷ߩ

፣უ․ᕈࠍ⺞ߴࠆߎߣߪ㧘⮎೷ࠍㆬᛯߔࠆක≮⠪

ߦ᦭↪ߥᖱႎࠍਈ߃ࠆߎߣߦߥࠆ㧚ߘߎߢ㧘ᧄ⎇

ⓥߢߪ㧘⵾ᴺߩ⇣ߥࠆฦ⒳ߩㅦ፣უᕈ㍤೷ߦߟ޿

ߡ㧘㍤೷ࠍ᳓ߣߣ߽ߦ᦯↪ߔࠆ႐ว߅ࠃ߮ໜᶧߩ ߺߢ᦯↪ߔࠆ႐ว㧘ߐࠄߦ㧘ໜᶧߩߺߢ᦯↪ߔࠆ ႐วߦߪ㧘චಽߥໜᶧ㊂߇޽ࠆ႐ว෸߮ໜᶧಽᴲ ߇ૐਅߒߡ޿ࠆ႐วࠍᗐቯߒ㧘㪊⒳㘃ߩ⹜㛎ᴺࠍ

↪޿㧘᧦ઙࠍᄌ߃ߡ፣უ․ᕈࠍᲧセᬌ⸛ߒߚ㧚㩷

ᣇ ᴺ

㪈㪅㩷 ኻ⽎ක⮎ຠ㩷

ᧄ⎇ⓥߢ૶↪ߒߚㅦ፣უᕈ㍤೷ࠍ⴫㪈ߦ␜ߒ ߚ㧚㩷

㪉㪅㩷 ࠺ࠖࠬ࠻࠶ࡄ࡯㩷 ࠍ↪޿ߚ፣უᕈߩᬌ⸛㧔࠺ࠖ

ࠬ࠻࠶ࡄ࡯ᴺ㧕㩷

ㆡ㊂ߩ᳓ߢ᦯⮎ߔࠆ႐วࠍᗐቯߒߚ፣უࡊࡠ ࡈࠔࠗ࡞ࠍ㧘࠺ࠖࠬ࠻࠶ࡄ࡯㩷ᴺ^{㪈㪇㪃㪈㪈㪀}ߦࠃࠅ᳞߼ߚ

㧔㪠㫅㩷㪭㫀㫋㫉㫆㧕㧚ၮᧄߪዪᣇߩ፣უ⹜㛎ᴺߦᓥ޿㧘፣უ

⹜㛎ེߪ㪥㪫㪄㪉㪇㪇㧔ንጊ↥ᬺ㧔ᩣ㧕㧕ࠍ૶↪ߒ㧘⹜

㛎ᶧߦߪ㪊㪎͠ߩ♖⵾᳓㪐㪇㪇㫄㪣ࠍ↪޿ߚ㧚፣უߩᬌ

಴ ߦ↪ ޿ߚ፣ უ⚳ ੌ⥄േ ᬌ಴ⵝ⟎࠺ ࠖࠬ ࠻࠶

ࡄ࡯㩷 㧔ንጊ↥ᬺ 㪫㪢㪄㪊㪍㪉㪚㪧㧕ߩ᭴ㅧߣ઀⚵ߺࠍ

࿑㪈ߦ␜ߒߚ㧚ᱷᷲ⸳ቯࠍ㪇㫄㫄 ߆ࠄ㍤೷ෘ߹ߢ

㪇㪅㪌㫄㫄ೞߺߢ㗅ߦᄌൻߐߖߡ፣უᤨ㑆ࠍ᷹ቯߒߚ㧚

ߔߥࠊߜ㧘㍤೷ෘ߇㪇㫄㫄㧘㪇㪅㪌㫄㫄㧘㪈㪅㪇㫄㫄㧘㪈㪅㪌̖

ߦߥࠆ߹ߢߩᤨ㑆ࠍ᷹ቯߔࠆߎߣߢ㧘ቢోߦ፣უ ߔࠆ߹ߢߩࡊࡠ࠮ࠬ㧔ᤨ㑆ߣ㍤೷ߩෘߺߩ㑐ଥ㧕 ࠍᛠីߔࠆߎߣ߇ߢ߈ࠆ㧚ߥ߅㧘ᱷᷲ㪈㪅㪈㫄㫄એ਄

ߩ႐วߪ㧘․ᱶ࠺ࠖࠬࠢߩశゲㆤᢿㇱࠍߕࠄߒ㧘 ᱷᷲ⸳ቯߣ⚵ߺวࠊߖߡⴕߞߚ㧚᷹ቯߪ㧘ฦ⸳ቯ ᱷᷲᲤߦ㪍࿁ⴕߞߚ㧚㩷

㪊㪅㩷 㪦㪛㪄㫄㪸㫋㪼㩷 ࠍ↪޿ߚ፣უᕈߩᬌ⸛㧔㪦㪛㪄㫄㪸㫋㪼㩷 ᴺ㧕㩷

ᄙߊߩญ⣧ౝ፣უ㍤ߪ㧘ໜᶧߩߺߢ᦯↪ߢ߈ࠆ ߎߣࠍᮡ᭙ߒߡ޿ࠆ߇㧘ዪᣇߩ፣უ⹜㛎ᴺߪ㪐㪇㪇㩷 㩷

⴫㪈 ㅦ፣უᕈ㍤೷㩷

― 151 ―

㩷 ^㧙㪊㧙

㨙㪣ߩ⹜㛎ᶧߢ᷹ቯߔࠆߚ߼㧘ญ⣧ౝߩໜᶧߩߺߢ㧘

⥠ߣ਄޽ߏߦࠃߞߡട࿶ߐࠇߚ᧦ઙࠍട๧ߒߚ⹏

ଔ߇ߢ߈ߥ޿㧚ญ⣧ౝߦૃߚ᧦ઙߢ፣უᕈࠍ⹏ଔ ߔࠆᯏེߣߒߡญ⣧ౝ፣უ㍤⹜㛎ེ㪦㪛㪫㪄㪈㪇㪈㧔ን ጊ↥ᬺ㧕߇ઍ⴫⊛ߢ޽ࠆ߇㧘㍤೷ਅ㕙߇ࠊߕ߆ߦ

⹜㛎ᶧߦធߔࠆ⁁ᘒࠍ⹏ଔ^{㪈㪉㪃㪈㪊㪃㪈㪋㪀}ߒߡ޿ࠆ㧚ᧄ⎇ⓥ

ߢߪ㧘ญ⣧ౝ፣უ㍤⹜㛎ེ 㪦㪛㪄㫄㪸㫋㪼㩷 㧔੗ర⵾૞

ᚲ㧕ࠍ↪޿ߡ⹏ଔࠍⴕߞߚ㧚⹜㛎ᣇᴺߪޔၮᧄ⊛

ߦߪ㈬੗ࠄߩႎ๔^㪈㪌㪀ߦᓥ޿㧔ᄖ⩄㊀㪑㪈㪇㪇㪾㧘ౝ⩄

㊀㪑㪊㪇㪾㧘㫅㪔㪊㧕㧘᷹ቯㇱߩ⹜㛎ᶧ߳ߩᶐẃ૏⟎ࠍ⺞ᢛ ߔࠆߎߣߦࠃࠅ㧘㍤೷ో૕߇ᶐࠆ㧔ో૕ᶐẃ㧕㧘߹

ߚߪ㍤೷ߩਅ┵ߩߺ߆ࠄᶧ߇ᶐẢߔࠆ㧔ਅ┵ᶐẢ㧕 ߩ᧦ઙߢ㧘፣უᤨ㑆ࠍ᷹ቯߒߚ㧚ߔߥࠊߜ㧘᳓ߢ

᦯↪ߔࠆ႐วࠍᗐቯߒ㧘⹜㛎ᶧߣߒߡ㪈㪇㫄㪣⫳⇐᳓

ߩਛߦ㍤೷ో૕߇ᶐࠆ㧔ో૕ᶐẃ㧕᧦ઙߢ㧘ໜᶧ ߩߺߢ᦯↪ߔࠆ႐วࠍᗐቯߒ㧘ੱᎿໜᶧࠍ↪޿ߡ

㍤೷ߩਅ┵ߩߺ߆ࠄᶧ߇ᶐẢߔࠆ㧔ਅ┵ᶐẢ㧕ߩ

᧦ઙߢ㧘፣უᤨ㑆ࠍ᷹ቯߒߚ㧚⹜㛎ᶧߣߒߡ⫳⇐

᳓ࠍ↪޿ߚਅ┵ᶐẢߦߟ޿ߡ߽᷹ቯࠍⴕߥߞߚ㧚

ੱ Ꮏໜ ᶧߣ ߒߡ 㧘㪢㪚㫃㪑㪈㪅㪋㪎㪾㪆㪣㧘㪥㪸㪚㫃㪑㪈㪅㪋㪋㪾㪆㪣㧘 㪫㫎㪼㪼㫅㪏㪇㪑㪇㪅㪊㩼ߩ᳓ṁᶧࠍ↪޿ߚ^㪈㪍㪀㧚᷹ቯߪ㧘ߘࠇߙ ࠇߩ᧦ઙߢ㪊࿁ⴕߞߚ㧚㩷

㪋㪅㩷 ࠢ࡝࡯ࡊࡔ࡯࠲ࠍ↪޿ߚ፣უᕈߩᬌ⸛㧔ࠢ࡝࡯

ࡊࡔ࡯࠲ᴺ㧕㩷

ໜᶧߩߺߢ᦯↪ߒߚ႐วࠍᗐቯߒ㧘⹜㛎ᶧ㊂߇ 㪇㪅㪉㩷 㫄㪣 ߹ߚߪ㪈㪅㪇㩷 㫄㪣 ߩ᧦ઙߦ߅ߌࠆ፣უᕈࠍࠢ

࡝࡯ࡊࡔ࡯࠲㧔ဳᑼ㧦㪩㪜㪉㪄㪊㪊㪇㪇㪌㪪㧘㧔ᩣ㧕ጊ㔚㧕 ࠍ↪޿ߡ⹏ଔߒߚ㧔㪠㫅㩷 㪭㫀㫋㫉㫆㧕㧚ໜᶧߩಽᴲ㊂ߦߪ

⻉⺑޽ࠆ߇㧘ߎߎߢߪ㘵ፉߩ⎇ⓥ^㪈㪎㪀ࠍෳ⠨ߦ⧯ᐕ

⠪ߪ㪌㪅㪈㫄㪣㪆㪊㫄㫀㫅㧘㜞㦂⠪ߪ㪉㪅㪋㫄㪣㪆㪊㫄㫀㫅 ߣ઒ቯߒ㧘 㪊㪇⑽㑆ߢߪ⧯ᐕ⠪ߪ⚂㪇㪅㪐㫄㪣㧘㜞㦂⠪ߪ⚂㪇㪅㪋㫄㪣㧘 㪈㪌⑽㑆ߢߪ⧯ᐕ⠪ߪ⚂㪇㪅㪋㪌㫄㪣㧘㜞㦂⠪ߪ⚂㪇㪅㪉㫄㪣 ߣ⸘▚ߒߚ㧚ߔߥࠊߜ㧘⹜㛎ᶧ㊂߇㪇㪅㪉㩷㫄㪣ߪ㜞㦂

⠪ߩ㪈㪌⑽㑆ߩໜᶧ㊂㧘㪈㪅㪇㨙㪣ߪ⧯ᐕ⠪ߩ㪊㪇⑽㑆ߩ ໜᶧ㊂ࠍᗐቯߒߚ᧦ઙߢ޽ࠆ㧚⹜㛎ᶧߦߪ㧘ੱᎿ ໜ ᶧ ߣ ߒ ߡ 㧘 㪢㪚㫃㪑㪈㪅㪋㪎㪾㪆㪣㧘㪥㪸㪚㫃㪑㪈㪅㪋㪋㪾㪆㪣㧘 㪫㫎㪼㪼㫅㪏㪇㪑㪇㪅㪊㩼ߩ᳓ṁᶧࠍ↪޿ߚ^㪈㪍㪀㧚㩷

ࠢ࡝࡯ࡊࡔ࡯࠲ߣߪ㧘⎕ᢿᒝᐲ㧘ઃ⌕ᕈ㧘ಝ㓸 ᕈ߅ࠃ߮☼ᒢᕈߥߤߩ‛ᕈࠍ⹏ଔߔࠆ⹜㛎ེߢ

޽ࠆ㧚㪞㪅㩷 㪘㪹㪻㪼㫃㪹㪸㫉㫐^㪈㪏㪀ࠄߪ࠹ࠢࠬ࠴ࡖ࡯ࠕ࠽࡜ࠗ

ࠩ࡯ࠍ↪޿ߡญ⣧ౝ፣უ㍤ߩ፣უᤨ㑆ࠍ᷹ቯߒ ߚ߇㧘ᧄᴺߢߪߐࠄߦ◲ଢൻߒ㧘೑ଢᕈࠍะ਄ߐ ߖߚ㧚⹜㛎ߩ᭎⇛ࠍ࿑㪉ߦ␜ߒߚ㧚㊄ዻኈེౝߦ 㪈㪇㫄㫄ⷺߩࡔ࠶ࠪࡘࠍ⟎߈㧘ߘߩ਄ߦ⹜ᢱࠍ⟎߈㧘㩷 Ԙ㩷㍤೷ߩෘߺߛߌᬌ಴ࡄࠗࡊߪ㜞ߊߥߞߡ޿ࠆߚ߼㧘ࡄࠗࡊਛࠍశ߇ㅢㆊߢ߈ࠆ㧚㩷

ԙ㩷⹜㛎㐿ᆎ߆ࠄ㧘㍤೷߇፣უߒᆎ߼ࠆߣ㧘ᬌ಴ࡄࠗࡊߩ૏⟎ߪరߩၮḰߦㄭߠ߈㧘㍤೷߇ߔߴߡ፣უߔࠆߣశߩㅢㆊ߇ ㆤᢿߐࠇࠆ㧚ߎߩㆊ⒟ߩᤨ㑆ࠍ᷹ቯߔࠆ㧚㩷

Ԛ㩷ᱷᷲ⸳ቯߦࠃࠅ㧘⹜㛎㐿ᆎ߆ࠄ⸳ቯᱷᷲෘߦߥࠆ߹ߢߩᤨ㑆ࠍ᷹ቯߢ߈ࠆ㧚ᱷᷲ⸳ቯߪ㧘㪇㪅㪈㫄㫄න૏ߢ㪇㨪㪈㪅㪇㫄㫄߹ ߢ⸳ቯߢ߈ࠆ㧚㩷

ԛ㩷ᱷᷲ㪈㪅㪌㫄㫄㨪㪉㪅㪌㫄㫄߹ߢߩ᷹ቯߦߪ㧘శㆤᢿㇱࠍ㪈㪅㪌㫄㫄ਅߍߚᬌ಴ࡄࠗࡊࠍ↪޿ࠆ㧚ߎߩ႐ว㧘ᱷᷲෘ߇㨇ᱷᷲ⸳ቯ 㧗㪈㪅㪌㫄㫄㨉ߦߥࠆ߹ߢߩᤨ㑆ࠍ᷹ቯߔࠆ㧚ᱷᷲ㪊㪅㪇㨪㪋㪅㪇㫄㫄߹ߢߩ᷹ቯߦߪ㧘శㆤᢿㇱࠍ㪊㪅㪇㫄㫄ਅߍߚࡄࠗࡊࠍ↪޿ࠆ㧚

࿑㪈 ࠺ࠖࠬ࠻࠶ࡄ࡯㩷ߩ᭴ㅧߣ઀⚵ߺ㩷

㩷

― 152 ―

㩷 ^㧙㪋㧙

㍤೷ߩ㜞ߐㇱಽࠍᄌ૏࠯ࡠὐߣߒߚ㧚᮸⢽⵾ߩࡊ

࡜ࡦࠫࡖ࡯ߢ৻ቯ⩄㊀ߔࠆߣหᤨߦ⹜㛎ᶧࠍ㍤

೷ਅㇱߦࡇࡍ࠶࠻ࠍ↪޿ߡᷝടߒ㧘ᤨ㑆ߩ⚻ㆊߦ วࠊߖߡࡊ࡜ࡦࠫࡖ࡯ߩ࠯ࡠὐ߆ࠄߩᄌ૏ࠍ᷹

ቯߒߚ㧚㩷

ᦨᄢ⥠࿶ߦߟ޿ߡߪ㧘ᨋࠄߩ⎇ⓥ^㪈㪐㪀ߦࠃࠆߣᐕ 㦂㪉㪇㨪㪐㪌ᱦ ߩ ᦨ ᄢ ⥠ ࿶ ߪ 㧘 ᦨ ዊ㪋㪅㪉㫂㪧㪸㧘 ᐔ ဋ 㪉㪍㪅㪍㫂㪧㪸㧘ᦨᄢ㪊㪏㪅㪌㫂㪧㪸ߢ޽ߞߚ㧚ᧄ⎇ⓥߦ↪޿ߚ

㍤ ೷ ߩ ⋥ ᓘ ߪ ߔ ߴ ߡ㪏㪅㪌㫄㫄 ߥ ߩ ߢ 㧘 㕙 Ⓧ ߪ 㪇㪅㪌㪍㪎㪺㫄^㪉ߣߥࠅ㧘⩄㊀ߦ឵▚ߔࠆߣᦨዊ㪇㪅㪉㪋㪥㧘ᐔ ဋ㪈㪅㪌㪈㪥㧘ᦨᄢ㪉㪅㪈㪏㪥ߣߥࠆ㧚ߚߛߒ㧘㍤೷ߪ፣უ

ㆊ⒟ߦ߅޿ߡᓢޘߦዊߐߊߥߞߡ޿ߊߚ߼㧘㍤೷

߳ߩන૏㕙Ⓧ޽ߚࠅߩ⩄㊀ߔߥࠊߜ࿶ജߪᓢޘ ߦᄢ߈ߊߥࠆ㧚એ਄ߩߎߣࠍ㐓ߺߡ㧘ᧄ⎇ⓥߢߪ

㍤೷ߦ߆߆ࠆ⩄㊀ࠍ㧘㪇㪅㪌㧘㪌㪅㪇㧘㪈㪏㩷㪥ߩ㪊᳓Ḱߣߒ ߚ㧚᷹ቯߪ㧘ߘࠇߙࠇߩ᧦ઙߢ㪊࿁ⴕߞߚ㧚㩷

⚿ ᨐ

㪈㪅㩷 ࠺ࠖࠬ࠻࠶ࡄ࡯㩷 ᴺߦࠃࠆ፣უᕈߩᬌ⸛㩷 ฦ⒳ࡈࠔࡕ࠴ࠫࡦ⵾೷ߩ࠺ࠖࠬ࠻࠶ࡄ࡯㩷 ᴺߦ ࠃࠆฦᱷᷲ㊂߹ߢߩ፣უᤨ㑆෸߮፣უࡊࡠࡈࠔ

ࠗ࡞ࠍ࿑㪊ߦ␜ߔ㧚㩷 Ԙ㩷㍤೷ࠍ㊄✂਄ߦタߖ㧘ࡊ࡜ࡦࠫࡖߣធߔࠆ૏⟎ࠍᄌ૏㪇ߣߔࠆ㧚㩷

ԙ㩷⹜㛎ᶧࠍᷝടߔࠆߣหᤨߦ⩄㊀ߒ㧘ᄌ૏᷹ቯࠍ㐿ᆎߔࠆ㧚㩷 Ԛ㩷ᤨ㑆⚻ㆊߣߣ߽ߦ㍤೷ߪ፣უߒዊߐߊߥࠆ㧚㩷

ԛ㩷㪐㪇⑽߹ߢᄌ૏ࠍ᷹ቯߔࠆ㧚㩷 㩷

࿑㪉 ࠢ࡝࡯ࡊࡔ࡯࠲ᴺߦࠃࠆ፣უ⹜㛎ߩ᭎⇛࿑㩷 㩷

࿑㪊 ࠺ࠖࠬ࠻࠶ࡄ࡯㩷ᴺߦࠃࠆ፣უ⹜㛎㩷

― 153 ―

㩷 ^㧙㪌㧙

޿ߕࠇߩ⵾೷ߦ߅޿ߡ߽ੑ⋧ᕈߩ፣უࡊࡠࡈ ࠔࠗ࡞ࠍ␜ߒߚ㧚ߪߓ߼ߪᲧセ⊛ࠁߞߊࠅߣᱷᷲ

ෘ߇ᷫዋߔࠆ߇㧘ߎࠇߪ㍤೷ߩ⴫ጀ߇ዋߒߕߟ፣

ࠇࠆ߆ṁ⸃ߒߡ޿ࠆߎߣࠍ␜ߒߡ޿ࠆ㧔╙㪈Ბ㓏㧕㧚 ߘߩᓟ㧘ᕆㅦߦ፣უ߇ㅦ߹ࠅ㍤೷ో૕߇ቢోߦ፣

უߒߚ㧔╙㪉Ბ㓏㧕㧚╙㪈Ბ㓏ߩᤨ㑆ߪ⵾ຠ㑆ߢᏅ ߇⹺߼ࠄࠇߚ㧚㩷

㍤೷ߩ፣უߪ㧘ࡈࠔࡕࠬ࠲ࠫࡦ㩷 㧰㍤㧘ࡉࡠࠬ

࠲࡯㩷㧹㍤㧘ࡈࠔࡕ࠴ࠫࡦ㧰㍤ޟ㪜㪤㪜㪚ޠ㧘ࡈࠔࡕ

࠴ࠫࡦ㧰㍤ޟࠨࡢࠗޠ㧘ࠟࠬࡐ࡯࠻㩷 㧰㍤ߩ㗅ߦㅦ ߊ㧘ࠟࠬ࠲࡯㩷㧰㍤ߪ╙㪈Ბ㓏ߩᤨ㑆߇⚂㪌㪇⑽ߢ৻

⇟㐳߆ߞߚ㧚৻ᣇ㧘╙㪉Ბ㓏ߦⷐߔࠆᤨ㑆ߩ⵾ຠ

㑆ߩᏅߪᲧセ⊛ዊߐ߆ߞߚ㧚㩷

㪝㪛㪘ߪญ⣧ౝ፣უ㍤ߩࠟࠗ࠳ࡦࠬ^㪉㪇㪀ߢ፣უᤨ㑆 ߩ⋡቟ࠍ㪊㪇⑽એౝߣߒߡ޿ࠆ߇㧘ࠟࠬ࠲࡯㩷 㧰㍤

ߪߎߩၮḰࠍ਄࿁ࠆ⚿ᨐߣߥߞߚ㧚㩷 㪉㪅㩷㪦㪛㪄㫄㪸㫋㪼㩷 ߦࠃࠆ፣უᕈߩᬌ⸛㩷

⹜㛎ᶧ߇⫳⇐᳓ߢߩో૕ᶐẃ෸߮ਅ┵ᶐẢ㧘߅ ࠃ ߮ ੱ Ꮏ ໜ ᶧ ߢ ߩ ਅ ┵ ᶐ Ả ߩ ᧦ ઙ ߦ ߅ ߌ ࠆ

㪦㪛㪄㫄㪸㫋㪼㩷 ߦࠃࠆฦࡈࠔࡕ࠴ࠫࡦ㍤ߩ፣უᤨ㑆ࠍ

࿑㪋ߦ␜ߒߚ㧚ߔߴߡߩࠨࡦࡊ࡞ߦ߅޿ߡ㧘⫳⇐

᳓ߣੱᎿໜᶧ㑆ߩ፣უᤨ㑆ߦ᦭ᗧߥᏅߪ⷗ࠄࠇ ߥ߆ߞߚ߇㧘ਅ┵ᶐẢߢߪ㧘ో૕ᶐẃߣᲧセߒߡ㧘

፣უᤨ㑆߇㐳ߊߥࠆ௑ะࠍ␜ߒߚ㧚㩷

ࠟࠬ࠲࡯㩷 㧰㍤ߢߪ㧘ో૕ᶐẃߢߪ⚂㪈㪉⑽ߢ፣

უߒߚ߇㧘ਅ┵ᶐẢߢߪ፣უᤨ㑆ߪ⚂㪊㪇⑽ߣߥߞ ߚ㧚㩷

ࠟࠬࡐ࡯࠻㩷 㧰㍤ߪో૕ᶐẃߢߪ㪉㪋⑽એౝߦ፣

უߒߚ߇㧘ਅ┵ᶐẢߢߪ㪊㪇⑽ࠍ਄࿁ࠆ⚿ᨐߣߥߞ ߚ㧚㩷

ࡈࠔࡕࠬ࠲ࠫࡦ㩷㧰㍤߅ࠃ߮ࡈࠔࡕ࠴ࠫࡦ㧰㍤

ޟࠨࡢࠗޠߪో૕ᶐẃߢߪ㪈㪌⑽೨ᓟߩ፣უᤨ㑆ߢ

޽ߞߚ߇㧘ਅ┵ᶐẢߢߪ㧘㪉㪌⑽೨ᓟߩ፣უᤨ㑆ߢ

޽ߞߚ㧚㩷

ࡉ ࡠ ࠬ ࠲ ࡯㩷 㧹 ㍤ ߅ ࠃ ߮ ࡈ ࠔ ࡕ ࠴ ࠫ ࡦ 㧰 ㍤ ޟ㪜㪤㪜㪚ޠߪߤߩ᧦ઙߦ߅޿ߡ߽㪈㪇⑽એౝߣㅦ߿߆

ߦ፣უߒߚ㧚㩷

㪊㪅㩷ࠢ࡝࡯ࡊࡔ࡯࠲ߦࠃࠆ፣უᕈߩᬌ⸛㩷

⩄㊀ߣ⹜㛎ᶧߩᷝട㊂ࠍࡄ࡜ࡔ࡯࠲ߣߒߡ㧘ᤨ

㑆ߦኻߒߡ㍤೷ߩᄌᒻࠍ࿑㪌ߦ␜ߒߚ㧚ᄌᒻ߇ࡊ

࡜࠻࡯ߦ㆐ߒߚᤨὐ߇፣უᤨ㑆ࠍ␜ߒ㧘ࡊ࡜࠻࡯

ߦ㆐ߒߚᄌ૏㩿㫄㫄㪀ߣฦ⵾ຠߩ㍤೷ෘߐ㩿㫄㫄㪀ߩᏅ ߇ᄢ߈޿߶ߤ㧘ਇṁᕈߩᱷᷲ߇ᄙ޿ߎߣࠍ␜ߒߡ

޿ࠆ㧚߹ߚ㧘ᄌ૏ߩᢙ୯߇ࡑࠗ࠽ࠬߩ୯ߪ㍤೷߇

⤘Ảߒߡ޿ࠆߎߣࠍᗧ๧ߒߡ޿ࠆ㧚㩷

ࠟࠬ࠲࡯㩷 㧰㍤ߪ㧘㪈㪏㪥 ߩ⩄㊀᧦ઙਅߢ㪈㪅㪇㫄㪣 ߅ࠃ߮㪇㪅㪉㫄㪣ߩ޿ߕࠇߩᶧ㊂ߦ߅޿ߡ߽㪉㪇ᢙ⑽ߢ

፣უߒߚ߇㧘㪇㪅㪌㪥 ⩄㊀ᤨߦߪ፣უߦ޿ߕࠇ߽㪍㪇

⑽⒟ࠍⷐߒߚ㧚ߔߥࠊߜ㧘⩄㊀ߦࠃࠅ፣უᤨ㑆߇ ᄢ߈ߊᄌൻߔࠆߎߣ߇᣿ࠄ߆ߣߥߞߚ㧚㩷

ࠟࠬࡐ࡯࠻㩷 㧰㍤ߪ㧘ߔߴߡߩ᧦ઙߢ㧘፣უߦ

㪌㪇⑽એ਄ߩᤨ㑆߇߆߆ࠅ㧘ᶧ㊂㪇㪅㪉㫄㪣ߢ⩄㊀߇㪇㪅㪌

߹ߚߪ㪌㪥ߩ᧦ઙߢߪ㧘㪐㪇⑽ߩ᷹ቯᤨ㑆ౝߦ፣უߒ ߥ߆ߞߚ㧚㩷

ࡈࠔࡕࠬ࠲ࠫࡦ㩷 㧰㍤߅ࠃ߮ࡈࠔࡕ࠴ࠫࡦ㧰㍤

ޟࠨࡢࠗޠߪ޿ߕࠇ߽㧘ᶧ㊂㪇㪅㪉㫄㪣㧘⩄㊀㪇㪅㪌㪥ߩ᧦

ઙߢߪ㍤೷ߪ⤘Ảߒ㧘㪐㪇⑽ߩ᷹ቯᤨ㑆ౝߦߪ߹ߞ ߚߊ፣უߒߥ߆ߞߚ㧚ߘߩઁߩ᧦ઙਅߢߪ㪊㪇㨪㪌㪇

⑽ߢ፣უߒߚ߇㧘⹜㛎ᶧ㊂߇㪐㪇㪇㩷㫄㪣ߢ᷹ቯߒߚ࠺

ࠖࠬ࠻࠶ࡄ࡯㩷 ᴺࠃࠅ㕖Ᏹߦㆃߊߥࠆ௑ะࠍ␜ߒ ߚ㧚㩷

ࡉ ࡠ ࠬ ࠲ ࡯㩷 㧹 ㍤ ߅ ࠃ ߮ ࡈ ࠔ ࡕ ࠴ ࠫ ࡦ 㧰 ㍤ ޟ㪜㪤㪜㪚ޠߪ㧘޿ߕࠇߩ⩄㊀㧘ᶧ㊂ߦ߅޿ߡ߽㧘቟

ቯߒߡ㪉㪇⑽೨ᓟߢ፣უߒߚ㧚߹ߚ㧘ᱷᷲෘ߇ᦨ߽

ዋߥ޿ߎߣ߇ಽ߆ߞߚ㧚㩷

⠨ ኤ

ญ⣧ౝ፣უ㍤ߪ㧘ญ⣧ౝߢߩ፣უᤨ㑆ߩߺ߇㊀ ⷐߥ‛ᕈߢߪߥߊ㧘᦯↪ᤨߩญߩਛߢߩࡑ࠙ࠬࡈ

ࠖ࡯࡝ࡦࠣ㧔᦯↪ᗵ㧕߽㕖Ᏹߦ㊀ⷐߥ‛ᕈߢ޽ࠆ㧚 ታ㓙㧘ญ⣧ౝߢߩ㍤೷ߩ፣უ㪆ṁߌౕว㧔፣უߔ ࠆࡄ࠲࡯ࡦ㧕ߪએਅߩઍ⴫⊛ߥࡊࡠࡈࠔࠗ࡞߇੍

᷹ߐࠇࠆ㧚㩷

Ԙ㩷 ዋ㊂ߩໜᶧߢ߽㧘㍤೷ߦ᳓ಽ߇ᶐẢߒ㧘㍤೷

ో૕߇৻᳇ߦ፣უߔࠆ㧚㩷

㽳㩷 ᳓߇චಽߦ޽ࠆ႐ว㧘㍤೷ߪ᳓ࠍๆ޿ߥ߇ࠄ

⴫㕙ߪ✭߿߆ߦ፣უߒ㧘㍤೷ߩ⧌߹ߢ᳓ಽ߇ᶐ ㅘߒߚᓟ㧘ߎߩ⧌߇৻᳇ߦ፣უߔࠆ㧚㩷

㽴㩷 ㍤೷ߩ⴫ጀ߇ࠥ࡞⁁ߦߥࠅ㧘ߪߓ߼ߩ߁ߜߪ

፣უ߇ㆃ޿߇㧘㍤೷ߩ⧌߹ߢ᳓ಽ߇೔㆐ߔࠇ߫

৻᳇ߦ፣უߔࠆ㧚㩷 㩷

― 154 ―

㩷 ^㧙㪍㧙

࿑㪋 㪦㪛㪄㫄㪸㫋㪼㩷ߦࠃࠆ፣უ⹜㛎㩷 ᐔဋ୯rᮡḰ஍Ꮕࠍ␜ߒߚ㧚㩷

㩷 㩷 㩷

࿑㪌 ࠢ࡝࡯ࡊࡔ࡯࠲ߦࠃࠆ፣უ⹜㛎㩷 㩷

٨㧧⩄㊀㪇㪅㪌㪥㧘⹜ᶧ㊂㪇㪅㪉㫄㪣㧘䂹㧧㪌㪥㧘㪇㪅㪉㫄㪣㧘䂓㧧㪈㪏㪥㧘㪇㪅㪉㫄㪣㧘٤㧧㪇㪅㪌㪥㧘㪈㪅㪇㫄㪣㧘䂺㧧㪌㪥㧘㪈㪅㪇㫄㪣㧘䂔㧧㪈㪏㪥㧘㪈㪅㪇㫄㪣㧘

― 155 ―

㩷 ^㧙㪎㧙

㽵㩷 ో૕߇⴫ጀ߆ࠄᓢޘߦหߓㅦᐲߢ፣უߔࠆ㧚㩷 ᧄ⎇ⓥߢߪ㧘㪊⒳ߩ 㪠㫅㩷 㪭㫀㫋㫉㫆 ⹜㛎ߦࠃࠆࠪࡒࡘ

࡟࡯࡚ࠪࡦ⹏ଔߢ㧘ߎࠇࠄߩ፣უౕว㧔ࡄ࠲࡯ࡦ㧕 ࠍ੍᷹ߒߚ㧚㩷

ᄙሹ⾰ᒻᚑ૕⵾೷ߢ޽ࠆࠟࠬ࠲࡯㩷 㧰㍤ߪ㧘᳓

ߢ᦯↪ߔࠆ႐วࠍᗐቯߒߚ࠺ࠖࠬ࠻࠶ࡄ࡯㩷 ᴺߢ ߪ㧘ߪߓ߼ߩ߁ߜߪ፣უ߇ࠁߞߊࠅㅴߺ㪌㪇⑽߶ߤ ߆ࠄ৻᳇ߦ፣უߒߚ㧚፣უߩࡄ࠲࡯ࡦߪԚߦ⋧ᒰ ߔࠆߣ⠨߃ࠄࠇࠆ㧚࠺ࠖࠬ࠻࠶ࡄ࡯㩷 ᴺߢߪ㍤೷

ߦ⩄㊀߇߆߆ࠄߥ޿ߚ߼㧘⹜㛎ᶧ߇㪐㪇㪇㨙㪣޽ߞߡ

߽፣უ߇ㆃߊߥࠆࠃ߁ߢ޽ࠆ㧚ߒ߆ߒ㧘᳓ߢ᦯⮎

ߔࠆ႐ว㧘ྚਅߔࠆ߹ߢญ⣧ౝߢ㪌㪇⑽߇⚻ㆊߔࠆ ߣߪ⠨߃ߦߊ޿ߚ߼㧘ญ⣧ౝ፣უ㍤ߢ޽ߞߡ߽㧘 ᖚ⠪ߦߣߞߡ᦯↪ᕈࠍ⦟ߊߔࠆࡔ࡝࠶࠻ߪ޽߹

ࠅή޿ߣ⸒߃ࠆ㧚㪦㪛㪄㫄㪸㫋㪼㩷 ߢߪ㧘᳓ߢߩ᦯↪ࠍ ᗐቯߒߚో૕ᶐẃߢߪ㪈㪇⑽߶ߤߢ፣უߒߚ߇㧘ໜ ᶧߩߺߢߩ᦯↪ࠍᗐቯߒߚਅ┵ᶐẢߢߪ⚂㪊㪇⑽ ߣߥߞߚ㧚߹ߚ㧘⥠࿶ߣໜᶧ㊂ߩᓇ㗀ࠍࡄ࡜ࡔ࡯

࠲ ߦ፣ უࡊࡠ ࡈࠔ ࠗ࡞ࠍ ᷹ቯ ߢ߈ࠆ ࠢ࡝ ࡯ࡊ ࡔ࡯࠲ᴺߢߪ㧘⩄㊀ߔߥࠊߜ⥠࿶߇㜞޿ߣ፣უߒ

߿ߔ޿߇㧘⥠࿶߇ૐ޿႐วߦߪ፣უߦᤨ㑆߇߆߆ ࠆߎߣ߇␜ໂߐࠇߚ㧚ߔߥࠊߜ㧘ࠟࠬ࠲࡯㩷 㧰㍤

ߪ፣უᤨ㑆߳ߩ⥠࿶ߩᓇ㗀߇ᄢ߈޿⵾೷ߢ޽ࠅ㧘

᳓ߢ᦯↪ߔࠆࠃ߁ߥ⥠࿶߇߆߆ࠅߦߊ޿᧦ઙߢ ߪ㧘፣უ߇ㆃߊߥࠆߣ⠨߃ࠄࠇࠆ㧚ߎࠇߪ㧘ᤊ㊁ ࠄߩ⎇ⓥ⚿ᨐ^㪉㪈㪀ࠍᡰᜬߔࠆ߽ߩߢ޽ࠅ㧘ࠟࠬ࠲࡯

㩷 㧰㍤ߪ᳓ήߒߢ᦯↪ߒߚ႐วߦญ⣧ౝߢߩ፣უ ࠍㆃߊߔࠆߎߣߦࠃࠅ⧰ߺࠍᛥ߃ߡ޿ࠆߣផቯ ߐࠇࠆ㧚㩷

ࠟࠬࡐ࡯࠻㩷 㧰㍤ߪ፣უᯏ᭴Ꮏᄦ⵾೷ߢ޽ࠆ㧚

ࠟࠬࡐ࡯࠻㩷 㪛 ㍤ߩ࠺ࠖࠬ࠻࠶ࡄ࡯㩷ᴺߢߩᱷᷲ

ෘߩᷫዋߪ߶߷⋥✢⊛ߢ޽ࠅ㧘፣უࡄ࠲࡯ࡦߪԛ ߦ⋧ᒰߔࠆߣ⠨߃ࠄࠇࠆ㧚᳓߇㪐㪇㪇㫄㪣ߩ࠺ࠖࠬ࠻

࠶ࡄ࡯㩷 ᴺߢߪ㪊㪇⑽એౝߦ፣უߒߚ߇㧘ࠢ࡝࡯ࡊ ࡔ࡯࠲ᴺߩ㪇㪅㪉㫄㪣ߩ⹜㛎ᶧ㊂ߢߪૐ⩄㊀㧔㪇㪅㪌㪥㧘

㪌㪥㧕ߢ፣უߒߥ߆ߞߚ㧚⩄㊀㪈㪏㪥߆ߟ⹜㛎ᶧ㊂㪈㫄㪣

ߩ᧦ઙߢ߽㧘፣უᤨ㑆ߪ㪌㪇⑽ࠍ⿥߃ߚ㧚ᦨᄢ⥠࿶

߇㪊㪏㪅㪌㫂㪧㪸 ߢ㍤೷ᓘ߇㪏㪅㪌㫄㫄 ߩ߹߹ߣ઒ቯߒߚ႐ วߩ⩄㊀߇㪉㪅㪈㪏㪥 ߢ޽ࠆߎߣ߆ࠄ㧘ໜᶧߢ᦯↪ߔ ࠆ႐ว㧘․ߦญ⣧ੇ῎∝ߩᖚ⠪ߦߣߞߡߪ㧘᦯↪

ᕈߦ㔍߇޽ࠆߣ⠨߃ࠄࠇࠆ㧚㪦㪛㪄㫄㪸㫋㪼㩷ߦࠃࠆ⹏

ଔߦ߅޿ߡ߽ਅ┵ᶐẃߩ᧦ઙߢ፣უᤨ㑆߇㐳ߊ ߥࠅ㧘ห᭽ߩ௑ะߢ޽ߞߚ㧚㩷

ࡈࠔࡕࠬ࠲ࠫࡦ㩷 㧰㍤ߪ፣უᯏ᭴Ꮏᄦ⵾೷ߢ޽

ࠆ㧚࠺ࠖࠬ࠻࠶ࡄ࡯㩷 ᴺߢߪ⚂㪈㪇⑽ߢ፣უߒ㧘㪍⵾

೷ਛᦨ߽ㅦ߆ߞߚߩߢ㧘᳓ߢ᦯↪ߔࠆߦߪㆡߒߡ

޿ࠆߣផኤߐࠇࠆ㧚㪦㪛㪄㫄㪸㫋㪼㩷 ߦࠃࠆ᷹ቯߢߪ㧘 㪊㪇⑽એౝߦ፣უߒߚ㧚ߒ߆ߒ㧘ࠢ࡝࡯ࡊࡔ࡯࠲ᴺ ߢߪ㧘޿ߕࠇߩ᧦ઙߢ߽፣უᤨ㑆ߪ㪊㪇⑽ࠍ⿥߃ߚ㧚

․ߦૐ⩄㊀࡮ૐᶧ㊂ߢߪ⤘Ảߒߚߛߌߢ㧘ోߊ፣

უߒߥ߆ߞߚ㧚ߎࠇࠄߩߎߣ߆ࠄ㧘፣უߦߪචಽ ߥ᳓ಽ߇ᔅⷐߢ޽ࠆߎߣ߇␜ໂߐࠇߚ㧚፣უߩࡊ ࡠࡈࠔࠗ࡞ߪԙߦ⋧ᒰߔࠆߣ⠨߃ࠄࠇࠆ㧚㩷

ࡈࠔࡕ࠴ࠫࡦ㧰㍤ޟࠨࡢࠗޠߪ፣უᯏ᭴Ꮏᄦ⵾

೷ߢ޽ࠆ㧚࠺ࠖࠬ࠻࠶ࡄ࡯㩷 ᴺߢߪ㪉㪇⑽એౝߦ፣

უߒ㧘㪦㪛㪄㫄㪸㫋㪼㩷ߦࠃࠆ᷹ቯߢ߽㪊㪇⑽એౝߦ፣უ ߒߚ㧚৻ᣇ㧘ࠢ࡝࡯ࡊࡔ࡯࠲ᴺߢߪ㧘޿ߕࠇߩ᧦

ઙߢ߽፣უᤨ㑆ߪ㪋㪇⑽ࠍ⿥߃ߚ㧚ࡈࠔࡕࠬ࠲ࠫࡦ 㩷 㧰㍤ߣห᭽ߦ㧘ૐ⩄㊀࡮ૐᶧ㊂ߢߪ⤘Ảߒߚߛ ߌߢ㧘ోߊ፣უߒߥ߆ߞߚߎߣ߆ࠄ㧘፣უߦߪ߿

ߪࠅචಽߥ᳓ಽ߇ᔅⷐߢ޽ࠆߎߣ߇᣿ࠄ߆ߣߥ ߞߚ㧚፣უߩࡊࡠࡈࠔࠗ࡞ߪԙߦ⋧ᒰߔࠆߣ⠨߃ ࠄࠇࠆ㧚ࡈࠔࡕࠬ࠲ࠫࡦ㩷 㧰㍤߅ࠃ߮ࡈࠔࡕ࠴ࠫ

ࡦ㧰㍤ޟࠨࡢࠗޠߦ߅޿ߡ㧘ໜᶧߩߺߢ᦯↪ߔࠆ ߦߪ፣უߦ㪊㪇⑽એ਄ߣᤨ㑆߇߆߆ࠅ㧘ໜᶧ㊂߇ૐ ਅߒߡ޿ࠆᖚ⠪߿⥠࿶ߩૐ޿ᖚ⠪ߦߪਇะ߈ߣ ផ᷹ߐࠇࠆ㧚ૐ⩄㊀ߩ㓙ߦ৻ㆊᕈߦ㍤೷߇⤘Ảߔ ࠆ⃻⽎ߪ㧘㈩วߐࠇߡ޿ࠆ፣უ೷߇ๆ᳓ߒߚߚ߼

ߣ⠨߃ࠄࠇ㧘ໜᶧߩߺߢ᦯↪ߒߚ㓙ߦญ⣧ౝߢߩ ࡕࠨࡕࠨߒߚ᦯↪ᗵࠍਈ߃ࠆน⢻ᕈ߇␜ໂߐࠇ ࠆ㧚㩷

ࡉ ࡠ ࠬ ࠲ ࡯㩷 㧹 ㍤ ߅ ࠃ ߮ ࡈ ࠔ ࡕ ࠴ ࠫ ࡦ 㧰 ㍤ ޟ㪜㪤㪜㪚ޠߪḨ⵾㍤ߢ޽ࠆ㧚࠺ࠖࠬ࠻࠶ࡄ࡯㩷ᴺߢ ߪ㪈㪌⑽೨ᓟߢ፣უߒߚ㧚㪦㪛㪄㫄㪸㫋㪼㩷 ߦࠃࠆ᷹ቯߢ ߪ㧘ߔߴߡߩ᧦ઙߢ㪈㪇⑽એౝߦ፣უߒߚ㧚߹ߚ㧘

ࠢ࡝࡯ࡊࡔ࡯࠲ᴺߢ߽ߔߴߡߩ᧦ઙߦ߅޿ߡ㪊㪇

⑽એౝߦ፣უߒߚ㧚፣უߩࡊࡠࡈࠔࠗ࡞ߪԘߦ⋧

ᒰߔࠆߣ⠨߃ࠄࠇࠆ㧚ࡉࡠࠬ࠲࡯㩷㧹㍤߅ࠃ߮ࡈ ࠔࡕ࠴ࠫࡦ㧰㍤ޟ㪜㪤㪜㪚ޠߪ㧘ߔߴߡߩ⹜㛎ᴺߦ ߅޿ߡ㧘⩄㊀ߩᄢዊ㧘ᶧ㊂ߩᄙዋߩ޿ߕࠇߩ᧦ઙ ߦ߅޿ߡ߽቟ቯߒߡㅦ߿߆ߦ፣უߒߚ㧚㩷

એ਄ߩ⠨ኤࠍ㧘ᛛⴚಽ㘃߅ࠃ߮፣უࡊࡠࡈࠔࠗ㩷

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㩷 ^㧙㪏㧙

⴫㪉 ᛛⴚಽ㘃߅ࠃ߮፣უࡊࡠࡈࠔࠗ࡞ߣฦ⒳⹏ଔᣇᴺߢߩ፣უᕈ㩷

࡞ߢ߹ߣ߼㧘⹏ଔᣇᴺ೎ߦᢛℂߒ㧘⴫㪉ߦ␜ߒߚ㧚

♧ዩ∛⮎߹ߚߪᶖൻᕈẩ≌⮎ߩญ⣧ౝ፣უ㍤ࠍ ಣᣇߐࠇߚᖚ⠪ࠍኻ⽎ߣߒߚᑿ೥ࠄߩ⺞ᩏ^㪈㪀߆ࠄ㧘 ᄙߊߩᖚ⠪ߪⶄᢙߩ⮎೷ࠍಣᣇߐࠇߡ߅ࠅ㧘หᤨ

ߦⶄᢙߩ㍤೷ࠍ᳓ߢ᦯↪ߔࠆߎߣࠍႎ๔ߒߡ޿

ࠆ㧚ߘߩਛߦญ⣧ౝ፣უ㍤߇฽߹ࠇߡ޿ߚߣߒߡ

߽㧘ㆡ㊂ߩ᳓ߣߣ߽ߦ᦯↪ߐࠇࠆ㧚ߎߩ႐วߩㅦ

፣უᕈ㍤೷ߩ᦭↪ᕈߪ㧘࠺ࠖࠬ࠻࠶ࡄ࡯㫤ᴺ߅ࠃ

߮㪦㪛㪄㫄㪸㫋㪼㫤ߩో૕ᶐẃታ㛎ߢផቯߢ߈ࠆߣ⠨߃

ࠄࠇࠆ㧚ߔߥࠊߜ㧘Ḩ⵾㍤߅ࠃ߮፣უᯏ᭴Ꮏᄦ⵾

೷߇᳓ߢ᦯⮎ߔࠆߩߦㆡߒߡ޿ࠆߣ޿߃ࠆ㧚㩷

৻ᣇ㧘ໜᶧߩߺߢ᦯↪ߔࠆߎߣࠍᗐቯߒߚ႐ว ߦߪ㧘⥠࿶ߣໜᶧ㊂ߩᓇ㗀ࠍ⠨ᘦߒߥߌࠇ߫ߥࠄ ߥ޿㧚⥠࿶ߣໜᶧ㊂ߦ໧㗴߇ߥ޿ᖚ⠪ߩ႐วߦߪ㧘 ᄙሹ⾰ᒻᚑ૕⵾೷㧘፣უᯏ᭴Ꮏᄦ⵾೷߅ࠃ߮Ḩ⵾

㍤ߩ޿ߕࠇߢ߽᦯↪ߦ໧㗴ߪߥ޿ߣ⠨߃ࠄࠇࠆ ߇㧘৻ㇱ⵾ㅧᴺߦࠃߞߡߪ፣უᤨ㑆߇㪊㪇⑽ࠍ⿥߃ ࠆ⵾೷߽޽ࠆߩߢ㧘ญ⣧ੇ῎∝ߩᖚ⠪߿⥠ᯏ⢻߇ ਇ⦟ߩᖚ⠪ߥߤߢߪᵈᗧ߇ᔅⷐߢ޽ࠆ㧚৻ᣇ㧘Ḩ

⵾㍤ߪ㧘ໜᶧ㊂߅ࠃ߮⥠࿶ߩᓇ㗀ࠍฃߌߦߊߊ㧘 ㅦ߿߆ߦ፣უߒ㧘ߔߴߡߩࠪ࠴ࡘࠛ࡯࡚ࠪࡦߦ߅

޿ߡㆡߒߡ޿ࠆ⵾೷ߢ޽ࠆߣ⠨߃ࠄࠇࠆ㧚㩷 ᧄ⎇ⓥߩ⚿ᨐࠃࠅ㧘ࡈࠔࡕ࠴ࠫࡦ฽᦭ߩฦ⒳ㅦ

፣უᕈ㍤೷ߪ㧘ญ⣧ౝ፣უ㍤ߢ޽ࠆ߆ߤ߁߆ߦ㑐 ࠊࠄߕ㧘⵾ᴺ߿ᷝട‛ߦࠃࠅߘߩ፣უᕈ߇ᄢ߈ߊ

⇣ߥߞߡ޿ࠆߎߣ߇␜ߐࠇߚ㧚ᦨㄭߢߪࠫࠚࡀ࡝

࠶ࠢක⮎ຠߩ૶↪߇ផᅑߐࠇ㧘ㅦ፣უᕈ㍤೷߽ห ᚑಽߩ⵾೷߇ᄙߊ⽼ᄁߐࠇߡ޿ࠆ㧚ߎࠇࠄߩㅦ፣

უᕈ㍤೷߽㧘ߘߩ⵾ᴺߦࠃࠅ㧘፣უ․ᕈߦᏅ߇޽

ࠆน⢻ᕈ߇␜ໂߐࠇߚ㧚߹ߚޔ㪝㪛㪘ߩࠟࠗ࠳ࡦࠬ

ߩၮḰߢߪ㧘㪐㪇㪇㫄㪣ߩ⹜㛎ᶧࠍ↪޿ߚዪᣇߩ፣უ

⹜㛎ߦ߅޿ߡญ⣧ౝ፣უ㍤ߩ፣უᤨ㑆ߪ㪊㪇⑽એ

ౝߣߐࠇߡ޿ࠆ^㪉㪇㪀㧚ᧄ⎇ⓥߩ⚿ᨐ㧘↪޿ࠆ⹜㛎ᴺ

ߦࠃࠅ⚿ᨐ߇ᄢ߈ߊ⇣ߥࠅ㧘⺋ߞߚ್ᢿߦዉ߆ࠇ ࠆน⢻ᕈ߽␜ߐࠇߚ㧚ญ⣧ౝ፣უ㍤ߩ቟ోߥ૶↪

ߩߚ߼ߦ߽㧘፣უ⹜㛎ᴺߩ᣿⏕ߥၮḰࠍ␜ߔߎߣ ߇ᔅⷐߢ޽ࠆ㧚㩷

ญ⣧ౝ፣უ㍤ߪޔྚਅ࿎㔍⠪߇ໜᶧߩߺߢ᦯⮎

ߔࠆߎߣߩෂ㒾ᕈ߽ᜰ៰^㪉㪉㪀ߐࠇߡ޿ࠆ㧚ฦ⵾೷ߩ

፣უ․ᕈߩ㆑޿ߪ᦯↪ߒ߿ߔߐ߿቟ోᕈߦᓇ㗀 ߒ㧘᦯↪ߒ߿ߔ޿⵾೷ߩㆬᛯ߇᦯⮎ࠦࡦࡊ࡜ࠗࠕ ࡦࠬߩะ਄ߦ⽸₂ߔࠆ߽ߩߣ⠨߃ࠄࠇࠆ㧚㩷

ෳ⠨ᢥ₂

㪈㪀㩷 ᑿ೥ฮม㧦ญ⣧ౝ፣უ㍤ߩ᦯⮎ᜰዉߩᬌ⸛㩷г ታᘒ⺞ᩏࠍ〯߹߃ߡг㧘㪫㪿㪼㫉㪸㫇㪼㫌㫋㫀㪺㩷㪩㪼㫊㪼㪸㫉㪺㪿㧘 㪉㪎㩿㪐㪀㧘㪈㪏㪍㪌㪄㪈㪏㪎㪇㧘㪉㪇㪇㪍㧚㩷

㪉㪀㩷 ਄᧖┨♿㧘㒙ਭᵤᑇ㧘Ṛᴛ ෼ ઁ㧦ญ⣧ౝ

፣უ㍤ߩࠦࡦࡊ࡜ࠗࠕࡦࠬߦਈ߃ࠆᓇ㗀ߦ ߟ޿ߡ㧘ᣣ∛⮎⹹㧘㪋㪊㩿㪎㪀㧘㪐㪌㪏㪄㪐㪍㪈㧘㪉㪇㪇㪎㧚㩷 㪊㪀㩷 ᾢᧁ⦟ᄥ㧘ୖ↰ߥ߅ߺ㧘 ጟ ⡡ ઁ㧦ⶄᢙ

㍤หᤨ᦯↪ᤨߩญ⣧ౝ፣უ㍤ߩ᦭↪ᕈߩᬌ

⸛㧘ᣣᧄ⮎೷ቇળ╙㪉㪍ᐕળ㧘㪧㪄㪇㪐㪋㧘㪉㪇㪈㪈㧚㩷 㪋㪀㩷 Ⴧ↰⟵ౖ㧦ญ⣧ౝ፣უ㍤ߩầᵹߣ⵾೷⸳⸘㧘

㪧㪟㪘㪩㪤㩷㪫㪜㪚㪟㩷㪡㪘㪧㪘㪥㧘㪉㪉㩿㪊㪀㧘㪋㪇㪈㪄㪋㪈㪉㧘㪉㪇㪇㪍㧚㩷 㪌㪀㩷 ⪭ว ᐽ㧦࡙࠾ࡃ࡯ࠨ࡞࠺ࠩࠗࡦ㧻㧰㍤ߩ㐿

⊒㧘⮎೷ቇ㧘㪎㪈㩿㪈㪀㧘㪈㪎㪄㪉㪇㧘㪉㪇㪈㪈㧚㩷

㪍㪀㩷 ᅏ↰ ⼾㧦㪩㪘㪚㪫㪘㪙ᛛⴚࠍᵴ↪ߒߚ㧻㧰㍤ߩ

⵾೷⸳⸘㧘⮎೷ቇ㧘㪎㪈㩿㪈㪀㧘㪉㪈㪄㪉㪌㧘㪉㪇㪈㪈㧚㩷 㪎㪀㩷 㪢㪼㪸㫉㫅㪼㫐㪃㩷㪧㪅㩷㪸㫅㪻㩷㪰㪸㫉㫎㫆㫆㪻㪃㩷㪩㪅㪡㪅㪆ട⮮ୃ੺⸶㧦ࠩ

ࠗ࠺ࠖࠬ㩷ญ⣧ౝㅦṁ⸃ဳ⚻ญᛩਈ⵾೷㧘 㪧㪟㪘㪩㪤㩷㪫㪜㪚㪟㩷㪡㪘㪧㪘㪥㪃㩷㪐㪃㩷㪎㪈㪊㪄㪎㪈㪐㧘㪈㪐㪐㪊㧚㩷 㪏㪀㩷 ኻ㚍ാ①㧦ᣂⷙㅦ፣㍤߅ࠃ߮ḨẢ☳૕ᛂ㍤ᯏ

ߩ㐿⊒㧘⵾೷ᛛⴚ⎇ⓥળ⹹㧘㪈㪇㩿㪋㪀㧘㪊㪇㪌㪄㪊㪈㪎㧘 㪉㪇㪇㪈㧚㩷

㪐㪀㩷 ᴒᧄ๺ੱ㧦ࠕࡓࡠࠫࡇࡦ㧻㧰㍤ޟ࠻࡯ࡢޠ㧘

― 157 ―

㩷 ^㧙㪐㧙

ࡈࠔ࡞ࡑࠪࠕ㧘㪋㪌㩿㪈㪈㪀㧘㪈㪈㪉㪌㪄㪈㪈㪉㪎㧘㪉㪇㪇㪐㧚㩷 㪈㪇㪀㩷 ✜ᣇ⾫ᰴ㧘㜞᧛ᓼੱ㧘ᨰᧁߐߟ߈ ઁ㧦ㅦ፣

უ ㍤ ߩ ፣ უ ⹜ 㛎 ᴺ ߦ 㑐 ߔ ࠆ ᬌ ⸛ 㧘㪡㫇㫅㪅㩷 㪡㪅㩷 㪧㪿㪸㫉㫄㪅㩷㪟㪼㪸㫃㫋㪿㩷㪚㪸㫉㪼㩷㪪㪺㫀㪅㧘㪉㪎㩿㪍㪀㧘㪌㪌㪊㪄㪌㪌㪏㧘㪉㪇㪇㪈㧚㩷 㪈㪈㪀㩷 ጊፒ໪ਯ㧘᳗↰዁ม㧘૒⮮᪸ᕺ ઁ㧦ㅦ፣უ

ᕈ㍤೷ߩญ⣧ౝ፣უᤨ㑆ߣ㪠㫅㩷㪭㫀㫋㫉㫆㩷፣უ⹜㛎 ᴺߩ⹏ଔ㧘㪡㫇㫅㪅㩷 㪡㪅㩷 㪧㪿㪸㫉㫄㪅㩷 㪟㪼㪸㫃㫋㪿㩷 㪚㪸㫉㪼㩷 㪪㪺㫀㪅㧘㩷 㪊㪉㩿㪈㪈㪀㧘㪈㪈㪉㪋㪄㪈㪈㪊㪉㧘㪉㪇㪇㪍㧚㩷

㪈㪉㪀㩷 㪥㪸㫉㪸㫑㪸㫂㫀㩷 㪩㪅㪃㩷 㪟㪸㫉㪸㪻㪸㩷 㪫㪅㪃㩷 㪫㪸㫂㪸㫄㫀㩷 㪥㪅㪃㩷 㪼㫋㩷 㪸㫃㪅㪑㩷 㪜㫍㪸㫃㫌㪸㫋㫀㫆㫅㩷 㫆㪽㩷 㫋㪿㪼㩷 㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫆㫅㩷 㫇㫉㫆㫇㪼㫉㫋㫀㪼㫊㩷 㫆㪽㩷 㪺㫆㫄㫄㪼㫉㪺㫀㪸㫃㩷 㪽㪸㫄㫆㫋㫀㪻㫀㫅㪼㩷 㪉㪇㩷 㫄㪾㩷 㫆㫉㪸㫃㫃㫐㩷 㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫅㪾㩷㫋㪸㪹㫃㪼㫋㫊㩷㫌㫊㫀㫅㪾㩷㪸㩷㫊㫀㫄㫇㫃㪼㩷㫅㪼㫎㩷㫋㪼㫊㫋㩷㪸㫅㪻㩷 㪿㫌㫄㪸㫅㩷 㫊㪼㫅㫊㫆㫉㫐㩷 㫋㪼㫊㫋㪅㪃㩷 㪚㪿㪼㫄㪅㩷 㪧㪿㪸㫉㫄㪅㩷 㪙㫌㫃㫃㪅㪃㩷 㪌㪉㪃㩷 㪎㪇㪋㩷 㪎㪇㪎㪃㩷㪉㪇㪇㪋㧚㩷

㪈㪊㪀㩷 㪟㪸㫉㪸㪻㪸㩷 㪫㪅㪃㩷 㪥㪸㫉㪸㫑㪸㫂㫀㩷 㪩㪅㪃㩷 㪥㪸㪾㫀㫉㪸 㪪㪅㪃㩷 㪼㫋㩷 㪸㫃㪅㪑㩷 㪘㩷 㫅㪼㫎㩷 㫄㪼㫋㪿㫆㪻㩷 㪽㫆㫉㩷 㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫆㫅㩷 㫊㫋㫌㪻㫀㪼㫊㩷 㫆㪽㩷 㫉㪸㫇㫀㪻㩷 㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫅㪾㩷 㫋㪸㪹㫃㪼㫋㪅㪃㩷 㪚㪿㪼㫄㪅㩷 㪧㪿㪸㫉㫄㪅㩷 㪙㫌㫃㫃㪅㪃㩷 㪌㪋㪃㩷 㪈㪇㪎㪉㩷 㪈㪇㪎㪌㪃㩷㪉㪇㪇㪍㧚㩷

㪈㪋㪀㩷 㪟㪸㫉㪸㪻㪸㩷㪫㪅㪃㩷㪥㪸㫉㪸㫑㪸㫂㫀㩷㪩㪅㪃㩷㪦㪿㫎㪸㫂㫀㩷㪫㪅㪃㩷㪼㫋㩷㪸㫃㪅㪑㩷㪜㪽㪽㪼㪺㫋㩷 㫆㪽㩷 㫇㪿㫐㫊㫀㪺㪸㫃㩷 㫇㫉㫆㫇㪼㫉㫋㫀㪼㫊㩷 㫆㪽㩷 㫆㫉㪸㫃㫃㫐㩷 㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫅㪾㩷 㫋㪸㪹㫃㪼㫋㫊㩷㫆㫅㩷㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫆㫅㩷㫋㫀㫄㪼㩷㪸㫊㩷㪻㪼㫋㪼㫉㫄㫀㫅㪼㪻㩷㪹㫐㩷㪸㩷 㫅㪼㫎㩷㪸㫇㫇㪸㫉㪸㫋㫌㫊㪅㪃㩷㪡㪅㩷㪛㫉㫌㪾㩷㪛㪼㫃㪅㩷㪪㪺㫀㪅㩷㪫㪼㪺㪿㪅㪃㩷㪉㪇㩿㪌㪀㪃㩷 㪊㪎㪎㪄㪊㪏㪊㪃㩷㪉㪇㪈㪇㪅㩷

㪈㪌㪀㩷 ㈬੗ ኡ㧘ዊጊඳ⟵㧘᭱㊁ ᱜ㧦⧰๧ࡑࠬࠠ

ࡦࠣ 㪦㪛 ㍤ߩ⵾೷⸳⸘ ๧ⷡ࠮ࡦࠨߦࠃࠆ

⧰๧⹏ଔߣ੩ㇺ⮎ຠᑼ㪦㪛㍤፣უᤨ㑆⥄േ᷹

ቯⵝ⟎ߦࠃࠆ፣უᤨ㑆⹏ଔ㧘⮎೷ቇ㧘㪎㪈㩿㪈㪀㧘 㪐㪄㪈㪍㧘㪉㪇㪈㪈㧚㩷

㪈㪍㪀㩷 Ꮤ⿷ᵗᐔ㧘┻ౝᵗᢥ㧘ᆌᏪ ൎ ઁ㧦ญ⣧ౝ

ㅦ፣უ㍤⹜㛎ᯏ࠻࡝ࠦ࡯ࡊ࠹ࠬ࠲ߩ㐿⊒㧘╙

㪉㪎࿁⵾೷ߣ☸ሶ⸳⸘ࠪࡦࡐࠫ࠙ࡓ⻠Ṷⷐᣦ 㓸㧘㪉㪎㧘㪉㪏㪄㪉㪐㧘㪉㪇㪈㪇㧚㩷

㪈㪎㪀㩷 㘵ፉ✍㇊㧦⧯ᐕ⠪ߣ㜞㦂⠪ߩ๧ⷡߣໜᶧಽᴲ

㊂ߩ㑐ㅪᕈߦߟ޿ߡ㧘᧲੩ᱤ⑼ᄢቇᱤ⑼ⴡ↢

჻ኾ㐷ቇᩞතᬺ⎇ⓥ⺰ᢥ㓸㧘㪉㪇㪉㪇㪇㪏㪄㪈㪈㪄㪉㪇㧘 㪉㪇㪇㪏㧚㩷

㪈㪏㪀㩷 㪘㪹㪻㪼㫃㪹㪸㫉㫐㪃㩷㪞㪅㪃㩷㪜㫆㫌㪸㫅㫀㪃㩷㪚㪅㪃㩷㪧㫉㫀㫅㪻㪼㫉㫉㪼㪃㩷㪧㪅㪃㩷㪼㫋㩷㪸㫃㪅㪑㩷 㪛㪼㫋㪼㫉㫄㫀㫅㪸㫋㫀㫆㫅㩷 㫆㪽㩷 㫋㪿㪼㩷 㫀㫅㩷 㫍㫀㫋㫉㫆㩷 㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫆㫅㩷 㫇㫉㫆㪽㫀㫃㪼㩷 㫆㪽㩷 㫉㪸㫇㫀㪻㫃㫐㩷 㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫅㪾㩷 㫋㪸㪹㫃㪼㫋㫊㩷 㪸㫅㪻㩷 㪺㫆㫉㫉㪼㫃㪸㫋㫀㫆㫅㩷 㫎㫀㫋㪿㩷 㫆㫉㪸㫃㩷 㪻㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫆㫅㪅㪃㩷 㪠㫅㫋㪅㩷 㪡㪅㩷 㪧㪿㪸㫉㫄㪅㪃㩷㪉㪐㪉㪃㩷㪉㪐㩷 㪋㪈㪃㩷㪉㪇㪇㪌㪅㩷

㪈㪐㪀㩷 ᨋ ੫㧘ᵤ⾐৻ᒄ㧘ศᎹፄട ઁ㧦ᚑੱߦ ߅ߌࠆᐕ㦂ߣ⥠࿶ߩ㑐ଥߦߟ޿ߡ㧘ᣣᧄ㗶ญ

⣧ᯏ⢻ቇળ㔀⹹㧘㪈㪇㩿㪈㪀㧘㪏㪇㪄㪏㪈㧘㪉㪇㪇㪊㧚㩷 㪉㪇㪀㩷 㪞㫌㫀㪻㪸㫅㪺㪼㩷 㪽㫆㫉㩷 㪠㫅㪻㫌㫊㫋㫉㫐㪑㩷 㪦㫉㪸㫃㫃㫐㩷 㪛㫀㫊㫀㫅㫋㪼㪾㫉㪸㫋㫀㫅㪾㩷

㪫㪸㪹㫃㪼㫋㫊㪃㩷㪝㫆㫆㪻㩷㪸㫅㪻㩷㪛㫉㫌㪾㩷㪘㪻㫄㫀㫅㫀㫊㫋㫉㪸㫋㫀㫆㫅㪃㩷㪚㪼㫅㫋㪼㫉㩷 㪽㫆㫉㩷㪛㫉㫌㪾㩷㪜㫍㪸㫃㫌㪸㫋㫀㫆㫅㩷㪸㫅㪻㩷㪩㪼㫊㪼㪸㫉㪺㪿㪃㩷㪉㪇㪇㪏㪅㩷 㪉㪈㪀㩷 ᤊ㊁ノᒾ㧘᳗↰㓷ሶ㧘ᓼ᳗ ⺈ ઁ㧦ࡈࠔࡕ

࠴ࠫࡦญ⣧ౝ፣უ㍤ߩవ⊒ຠߣᓟ⊒ຠߩຠ

⾰Ყセ⹜㛎㧘ᣣ∛⮎⹹㧘㪋㪊㩿㪊㪀㧘㪊㪐㪈㪄㪊㪐㪋㧘㪉㪇㪇㪎㧚㩷 㪉㪉㪀㩷 㚍ᧁ⦟ᢥ㧘㊁㦮࿦ሶ㧘᧖ਅ๟ᐔ ઁ㧦⥃ᐥ␹

⚻ቇ㧘㪋㪐㧘㪐㪇㪄㪐㪌㧘㪉㪇㪇㪐㧚㩷

― 158 ―

㩷 ^㧙㪈㪇㧙

Comparison of disintegration profiles of rapidly disintegrating tablets containing famotidine

Nobuhiro Murayama, Shihoko Funada, Norikazu Yoshida, Naomi Kurata, Akihiro Nakamura

㩷㪛㪼㫇㪸㫉㫋㫄㪼㫅㫋㩷㫆㪽㩷㪧㪿㪸㫉㫄㪸㪺㪼㫌㫋㫀㪺㪸㫃㩷㪪㪺㫀㪼㫅㪺㪼㫊㪃㩷㪪㪺㪿㫆㫆㫃㩷㫆㪽㩷㪧㪿㪸㫉㫄㪸㪺㫐㪃㩷㪪㪿㫆㫎㪸㩷㪬㫅㫀㫍㪼㫉㫊㫀㫋㫐㩷 㩷

Abstract

Many rapidly disintegrating tablets that have been marketed in Japan in recent years are manufactured by each company’s own methods and the disintegration times and disintegration profiles differ.

In this paper, the disintegration times and profiles of six types of commercial famotidine 20mg rapidly disintegrating tablets were evaluated under conditions simulating taking medicine with saliva only or with water. Marked differences in disintegration time and profile were noted among the products. Some disintegrated rapidly and were unaffected by variation in water and compression, others took time to disintegrate under conditions of little water or low compression. These differences were considered to be caused by manufacturing methods or additives. Differences in disintegration properties of each product had effects on ease of administration and safety, and the selection of products that were easy to administer appeared to contribute to improvement of patient compliance.

Key Words㧦molded tablet, orally disintegrating tablet, rapidly disintegrating tablet, disintegration test, generic medicine

㪩㪼㪺㪼㫀㫍㪼㪻㩷㪏㩷㪦㪺㫋㫆㪹㪼㫉㪉㪇㪈㪈㪒㩷㪸㪺㪺㪼㫇㫋㪼㪻㩷㪈㪈㩷㪥㫆㫍㪼㫄㪹㪼㫉㩷㪉㪇㪈㪈㪅㩷