2012-2014年度 （関連論文）
発表者氏名 論文タイトル 発表雑誌名 巻 頁 年
Okada Y, Shimane K, Kochi Y, T ahira T , Suzuki A, Higasa K, T akahashi A, Horit a T , Atsumi T , Ishii T , Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, It o S, T akada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed O W, Matsuda K, T erao C, Ohmura K, Myouzen K, Hosono N, T sunoda T , Nishimoto N, Mimori T , Matsuda F, T anaka Y, Sumida T , Yamanaka H, T akasaki Y, Koike T , Horiuchi T , Hayashi K, Kubo M, Kamatani N. Yamada R, Nakamura Y, Yamamoto K.
A genome-wide associat ion study identified AFF1 as a susceptibilit y locus for syst emic lupus eyrthematosus in Japanese.
PLoS Genet 2012
Okada Y, T erao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T , Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, T akahashi M, Sawada T , Nishioka Y, Yukioka M, Matsubara T , Wakitani S, T eshima R, T ohma S, T akasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, T anaka H, T ajima K, Suzuki T , Iwamoto T , Kawamura Y, T anii H, Okazaki Y, Sasaki T , Gregersen PK, Padyukov L, Worthington J, Siminovit ch KA, Lathrop M, T aniguchi A, T akahashi A, T okunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T , Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in t he Japanese populat ion.
Nat Genet. 44 511-6 2012
Okamoto A, Fujio K, T suno NH, T akahashi K, Yamamot o K
Kidney-infiltrating CD4+ T -cell clones
promote nephrit is in lupus-prone mice. Kidney Int. 82 969-79 2012
Myouzen K, Kochi Y, Okada Y, T erao C, Suzuki A, Ikari K, T sunoda T , T akahashi A, Kubo M, T aniguchi A, Matsuda F, Ohmura K, Momohara S, Mimori T , Yamanaka H, Kamatani N, Yamada R, Nakamura Y, Yamamoto K
Functional variants in NFKBIE and RT KN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.
PLoS Genet 2012
Iwasaki Y, Fujio K, Okamura T , Yanai A, Sumitomo S, Shoda H, T amura T , Yoshida H, Charnay P, Yamamoto K
Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL- 27-stimulated CD4+ T cells.
Eur J Immunol 43 1063-73 2013
Yamamoto K, T akeuchi T , Yamanaka H, Ishiguro N, T anaka Y, Eguchi K, Watanabe A, Origasa H, Shoji T , Sakamaki Y, van der Heijde D, Miyasaka N, Koike T .
Efficacy and safety of certolizumab pegol plus methotrexate in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate : the J-RAPID randomized, placebo-controlled trial.
Mod Rheumatol 2013
Nagafuchi Y, Sumitomo S, Soroida Y, Kanzaki T , Iwasaki Y, Michishita K, Iwai T , Ikeda H, Fujio K, Yamamoto K.
T he power Doppler twinkling artefact associated with periarticular calcification induced by intra-articular corticosteroid injection in patients with rheumatoid arthritis.
Ann Rheum Dis 72 1267-9 2013
山 本 一 彦
8:e1002455
8:e1002949
Epub ahead of print
Shimane K, Kochi Y, Suzuki A, Okada Y, Ishii T , Horita T , Saito K, Okamoto A, Nishimoto N, Myouzen K, Kubo M, Hirakata M, Sumida T , T akasaki Y, Yamada R, Nakamura Y, Kamatani N, Yamamoto K.
An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes.
Rheumatology(Oxfo
rd) 52 1172-82 2013
.Okada Y, et al(+94人), Yamamoto K and Plenge RM.
Genetics of rheumatoid arthritis contributes
to biology and drug discovery. Nature 506 376-381 2014
Kochi Y, Suzuki A, Yamamoto K Genetic basis of rheumatoid arthritis: a current review.
Biochem Biophys
Res Commun 452 254-62 2014
.Okamura T , Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T , Shoda H, Miyazaki J, Fujio K, Yamamoto K.
T GF-β3-expressing CD4+CD25-LAG3+
regulatory T cells control humoral immune responses.
Nat Commun 2015
Yamamoto K, Okada Y, Suzuki A and Kochi Y.
Genetics of rheumatoid arthritis in Asia―
present and future. Nat.Rev.Rheumatol 2015
発表者氏名 論文タイトル 発表雑誌名 巻 頁 年
Kono M, Yasuda S, Stevens RL, Koide H, Kurita T , Shimizu Y, Kanetsuka Y, Oku K, Bohgaki T , Amengual O, Horita T , Shimizu T , Majima T , Koike T , Atsumi T
RasGRP4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation.
Arthritis Rheumatol 2015
Kurita T , Yasuda S, Oba K, Odani T , Kono M, Otomo K, Fujieda Y, Oku K, Bohgaki T , Amenguak O, Horita T , Atsumi T
T he effect of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis
Rheumatology 54 39-44 2015
Kurita T , Yasuda S, Amengual O, Atsumi T
T he efficacy of calcineurin inhibitors for the treatment of interstitial lung disease associated with
polymyositis/dermatomyositis.
Lupus 24 3-9 2015
Kataoka H, Yasuda S, Fukaya S, Oku K, Horita T , Atsumi T , Koike T
Decreased expression of Runx1 and lowered production of Foxp3+ CD25+ CD4+
regulatory T cells in systemic sclerosis.
Mod Rheumatol 25 90-95 2015
Kono M, Yasuda S, Kato M, Kanetsuka Y, Kurita T , Fujieda Y, Otomo K, Horita T , Oba K, Kondo M, Mukai M, Yanai M, Fukasawa Y, Atsumi T
Long-term outcome in Japanese patients
with lupus nephritis Lupus 23 1124-1132 2014
Jin H, Arase N, Hirayasu K, Suenaga T , Saito F, T animura K, Matsuoka S, Ebina K, Shi K, T oyama-Sorimachi N, Yasuda S, Horita T , Hiwa R, T akasugi K, Ohmura K, Yoshikawa H, Saito T , Atsumi T , Sasazuki T , Katayama I, Lanier L, Arase H
Autotantibodies to IgG/HLA-DR complex are associated with rheumatoid arthritis susceptibility
PNAS 111 3787-3792 2014
Odani T , Yasuda S, Ota Y, Fujieda Y, Kon Y, Horita T , Kawaguchi Y, Atsumi T , Yamanaka H, Koike T
Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA- DRB5*01:05 allele in scleroderma patients with interstitial lung disease.
Rheumatology 64 504-512 2012
山 本 一 彦
保 田 晋 助
in press
in press
in press
T anaka Y, *Matsumoto I, Inoue A, Umeda N, T akai C, Sumida T .
Antigen-specific overexpression of human cartilage glycoprotein 39 on
CD4+CD25+Foxp3+ T reg cells in the generation of glucose-6-phosphate isomerase induced arthritis.
Clin Exp Immunol 177 419-27 2014
*Matsumoto I, Inoue A, T akai C, Umeda N, T anaka Y, Kurashima Y, Sumida T .
Regulatory roles of tumor necrosis factor alpha-induced proteins (T NFAIP) 3 and 9 in arthritis.
Clin Immunol 153 73-78 2014
Grunewald T G, Bach H, Cossarizza A, Matsumoto I.
T he ST EAP Protein Family: Versatile Oxidoreductases and T argets for Cancer Immunotherapy with Overlapping and Distinct Cellular Functions.
Biol Cell 104 641-657 2012
Inoue A, *Matsumoto I, T anaka Y, Umeda N, T anaka Y, Mihara M, T akahashi S, Sumida T .
Murine tumor necrosis factor α-induced adipose-related protein (tumor necrosis factor α-induced protein 9) deficiency leads to arthritis via interleukin-6 overproduction with enhanced NF-κB, ST AT -3 signaling, and dysregulated apoptosis of macrophages.
Arthritis Rheum 64 3877-3885 2012
Kondo Y, Iizuka M, Wakamatsu E, Yao Z, T ahara M, T suboi H, Sugihara M, Hayashi T , Yoh K, T akahiashi S, Matsumoto I, Sumida T
Overexpression of T -bet gene regulates
murine autoimmune arthritis. Arthritis Rheum. 64 162-172 2012
発表者氏名 論文タイトル 発表雑誌名 巻 頁 出版年
Nanke Y, Kobashigawa T , Yago T , Kawamoto M, Yamanaka H, Kotake S.
A novel peptide from T CT A protein inhibits proliferation of fibroblast-like synoviocyte (FLS) from rheumatoid arthritis patients.
Centr Eur J
Immunol 39 468-470 2014
Kotake S, Yago T , Kawamoto M, Nanke Y
A novel peptide from T -cell leukemia translocation-associated gene (T CT A) protein inhibits proliferatio of a small-cell lung carcinoma.
J Cancer T herapy 4 44-46 2013
Kotake S, Yago T , Kawamoto M, Nanke Y.
Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts.
Cell Biol Int 37 65-77 2013
Kotake S, Yago T , Kawamoto M, Nanke Y.
Human receptor activator of NF-κB ligand (RANKL) induces osteoclastogenesis of primates in vitro.
In Vitro Cell Dev
Biol Anim. 48 593-8 2012
Nanke N, Ishiguro N, Yago T , Kobashigawa T , Hashida T , Kotake S
T he role of regulatory T cells in mice with experimental autoimmune uveitis – a preliminary study
Centr Eur J
Immunol 37 102-5 2012
Yago T , Nanke Y, Kawamoto M, Yamanaka H, Kotake S
T acrolimus potently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human T h17 differentiation
Cytokine 59 252-7 2012
Kotake S, Nanke Y Effect of T NF-alpha on osteoblastogenesis
from mesenchymal stem cells Biochim Biophys Acta 1840 1209-13 2014
Kotake S, Yago T , Kawamoto M, Nanke Y
T he role of T -cell leukemia translocation- associated gene protein in human tumorigenesis and osteoclastogenesis
J Biomed Biotechnol 2012 675317 2012
Kotake S, Yago T , Kawamoto M, Nanke Y
Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial 'human osteoclastology'
J Bone Miner Metab 30 125-35 2012
Nanke Y, Kobashigawa T , Yago T , Kawamoto M, Yamanaka H, Kotake S
T umor necrosis factor-α and matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue is inhibited by blocking gap junction communication
Centr Eur J Immunol 37 237-242 2012
南家由紀 小竹 茂 M−CSF、GM−CSF 特集 リウマチ膠原病に
おける分子標的治療の最前線 最新医学 69 66-72 2014
小
竹
茂
松
本
功
Hanaoka H, Okazaki Y, Satoh T , Kaneko Y, Yasuoka H, Seta N, and
*Kuwana M.
Circulating anti-double-stranded DNA antibody-secreting cells in patients with systemic lupus erythematosus: a novel biomarker for disease activity.
Lupus 21 1284-1293 2012
Nishimoto T , Satoh T , Simpson EK, Ni H, and *Kuwana M.
Predominant autoantibody response to GPIb/IX in a regulatory T -cell-deficient mouse model for immune
thrombocytopenia.
J. T hromb. Haemost 11 369-372 2013
Nishimoto T , and *Kuwana M.
CD4+CD25+Foxp3+ regulatory T cells in pathophysiology of immune
thrombocytopenia.
Semin. Hematol 50 S43-S49 2013
Kuwana M Dysregulated negative immune regulators in
immune thrombocytopenia. ISBT Sci. Ser 9 217-222 2014
Nishimoto T , Numajiri M, Nakazaki H, Okazaki Y, and *Kuwana M
nduction of immune tolerance to platelet antigen by short-term thrombopoietin treatment in a mouse model of immune thrombocytopenia.
Int. J. Hematol 100 341-344 2014
西本哲也、竹内勤、桑名正隆 発性血小板減少性紫斑病の発症とレギュラト
リーT細胞. 臨床免疫 アレルギー科 58 124-117 2012
発表者氏名 論文タイトル 発表雑誌名 巻 頁 年
Ogasawara M，T amura N，Kageyama M，Onuma S，Kusaoi M，T oyama S，
Sekiya F，Matsudaira R，Nawata M，
T ada K，Matsushita M，Kempe K，
Amano H，Morimoto S，Yamaji K，
T akasaki Y．
Single-center，retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse events in 115 patients with rheumatoid arthritis．
Clin Rheumatol 31 251-7 2012
Ogasawara M，Murayama G，Yamada Y，
Nemoto T，Kageyama M，T oyama S，
Kusaoi M，Onuma S，Kon T，Sekiya F，
Sugimoto K，Matsudaira R，Matsushita M，T ada K，Kempe K，Yamaji K，
T amura N，T akasaki Y．
Autofeedback from ultrasound images provides rapid improvement in palpation skills for identifying joint swelling in rheumatoid arthritis．
J Rheumatol 39 1207-14 2012
Haruta K，Mori S，T amura N，Sasaki A，
Nagamine M，Yaguchi S，Kamachi F，
Enami J，Kobayashi S，Yamori T， T akasaki Y．
Inhibitory effects of ZST K474，a phosphatidylinositol 3-kinase inhibitor，on adjuvant-induced arthritis in rats．
Inflamm Res 61 551-62 2012
Ogasawara M，Kageyama M，Kusaoi M，
Onuma S，Kon T，Sekiya F，Sugimoto K，Matsudaira R，Matsushita M，T ada K，Kempe K，Yamaji K，T amura N，
T akasaki Y．
Recent trends in use of nonbiologic DMARDs and evaluation of their continuation rates in single and dual combination therapies in rheumatoid arthritis patients in Japan．
Mod Rheumatol 22 831-6 2012
田村直人 リウマチ性疾患におけるPI3キナーゼに関す
る最近の知見. 日免会誌 35 8-13 2012
田村直人, 多田久里守 脊椎関節炎の分子病態. リウマチ科 47: 130-
135, 2012. リウマチ科 47 130-5 2012
田村直人 関節リウマチ（RA）: 診断と治療の進歩.非生
物学的製剤.日内科会誌 日内科会誌 101 Sep-73 2012
田
村
直
人
桑
名
正
隆
Murayama G，Ogasawara M，Nemoto T，Yamada Y，Ando S，Minowa K，Kon T，T ada K，Matsushita M，Yamaji K，
T amura N，T akasaki Y．
Clinical miscount of involved joints denotes the need for ultrasound complementation in usual practice for patients with rheumatoid arthritis．
Clin Exp Rheumatol 31 506-14 2013
田村直人 抗炎症療法におけるunmet needs. PI3キ
ナーゼ阻害薬 .炎症と免疫 21 234-8 2013
Nemoto T，Ogasawara M，Matsuki Y，
Murayama G，Yamada Y，Sugisaki N，
Ando S，Minowa K，Kon T，T ada K，
Matsushita M，Yamaji K，T amura N，
T akasaki Y．
Can routine clinical measures predict ultrasound-determined synovitis and remission in rheumatoid arthritis patients?
Clin Exp
Rheumatol 32 5１-60 2014
T okai N, Ogasawara M, Gorai M, Matsuki Y, Yamada Y, Murayama G, Sugisaki N, Nemoto T , Ando S, Minowa K, Kon T , T ada K, Matsushita M, Yamaji K, T amura N, Makino S, T akasaki Y.
Predictive value of bone destruction and duration of clinical remission for subclinical synovitis in rheumatoid arthritis patients.
Mod Rheumatol 15 11１-6 2014
Gorai M，Ogasawara M，Matsuki Y，
Yamada Y，Murayama G，Sugisaki N，
Nemoto T，Ando S，Minowa K，Kon T，
T ada K，Matsushita M，Yamaji K，
T amura N，T akasaki Y．
Weighting with the Lansbury articular index improves the correlation of ultrasound score with serum matrix metalloproteinase-3 level in rheumatoid arthritis patients．
Mod Rheumatol 24 915-9 2014
田村直人，多田久里守，小林茂人，井上 久，髙崎芳成
強直性脊椎炎の病態：炎症と骨新生につい
て． 日脊椎関節炎会誌 4 19-24 2014
発表者氏名 論文タイトル 発表雑誌名 巻 頁 出版年
Endo A,Watanabe K, Ohye T , Matsubara T , Shimizu N, Kurahashi H, Yoshikawa T , Katano H, Inoue N, Imai K, T akagi M, Morio T , Mizutani S.
Molecular and virological evidence of viral activation from chromosomally integrated HHV-6A in a patient with X-SCID.
Clin. Infect. Dis. 59 545-8 2014
Nakatani K, Imai K, Shigeno M, Sato H, T ezuka M, Okawa T , Mitsuiki N, Isoda T , T omizawa D, T akagi M, Nagasawa M, Kajiwara M, Yamamoto M, Arai A, Miura O, Kamae C, Nakagawa N, Homma K, Nonoyama S, Mizutani S, Morio T .
Cord blood transplantation is associated with rapid B cell neogenesis compared with bone marrow transplantation.
Bone Marrow
T ransplant. 49 1155-61 2014
Wada T , Muraoka M, T oma T , Imai T , Shigemura T , Agematsu K, Haraguchi K, Moriuchi H, Oh-Ishi T , Kitoh T , Ohara O, Morio T , Yachie A.
Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening T ests for Chronic Granulomatous Disease.
J Clin Immunol. 33 857-64 2013
Kamae C, Nakagawa N, Sato H, Honma K, Mitsuiki N, Ohara O, Kanegane H, Pasic S, Pan-Hammerstrom Q, van Zelm M.C., Morio T , Imai K, Nonoyama S.
Common variable immunodeficiency classification by quantifying T -cell receptor and immunoglobulin κ-deleting
recombination excision circles.
J. Allerg. Clin.
Immunol. 131 1437-40 2013
Shimizu M, Kanegane H, Wada T , Motoyoshi Y, Morio T , Candotti F, Yachie A.
Aberrant glycosylation of IgA in Wiskott- Aldrich syndrome and X-linked thrombocytopenia.
J Allergy Clin
Immunol. 131 587-90 2013
Nakamura K, Du L, T unuguntla R, Fike F, Cavalieri S, Morio T , Mizutani S, Brusco A, Gatti RA.
Functional characterization and targeted correction of AT M mutations identified in Japanese patients with ataxia-telangiectasia.
Hum Mutat. 33 198-208 2012
Honda F, Kano H, Kanegane H, Nonoyama S, Kim E-S, Lee S-K, T akagi M, Mizutani S, Morio T .
Btk negatively regulates ROS production and stimulation-induced apoptosis in human neutrophils.
Nature Immunol. 13 369-78 2012
田 村 直 人
森
尾
友
宏
Okamura T , Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T , Shoda H, Miyazaki JI, Fujio K, Yamamoto K.
T GF-3-expressing CD4+CD25-LAG3+
regulatory T cells control humoral immune responses.
Nat
Communications 2015
Shoda H, Fujio K, Sakurai K, Ishigaki K, Nagafuchi Y, Shibuya M, Okamura T , Yamamoto K.
Autoantigen BiP-derived HLA-DR4 epitopes differentially recognized by effector and regulatory T cells in rheumatoid arthritis.
Arthritis &
Rheumatology. 2015
Sumitomo S, Fujio K, Okamura T , Morita K, Ishigaki K, Suzukawa K, Kanaya K, Kondo K, Yamasoba T , Furukawa A, Kitahara N, Shoda H, Shibuya M, Okamoto A, Yamamoto K.
T ranscription factor early growth response 3 is associated with the T GF-β1 expression and the regulatory activity of CD4-positive T cells in vivo.
J Immunol. 191 Sep-51 2013
Iwasaki Y, Fujio K, Okamura T , Yanai A, Sumitomo S, Shoda H, T amura T , Yoshida H, Charnay P, Yamamoto K.
Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL- 27 stimulated CD4(+) T cells.
Eur J Immunol. 43 1063-73 2013
Fujio K, Okamura T , Sumitomo S, Yamamoto K.
Regulatory cell subsets in the control of autoantibody production related to systemic autoimmunity.
Ann Rheum Dis. 72 Suppl
2 ii85-9. 2013
発表者氏名 論文タイトル 発表雑誌名 巻 頁 出版年
Iwata S, Nakayamada S, Fukuyo S, Kubo S, Yunoue N, Wang S-P, Yoshikawa M, Saito K, T anaka Y.
Activation of Syk in peripheral blood B cells in patients with rheumatoid arthritis: A potential target for abatacept therapy.
Arthritis Rheum
Kondo M, Yamaoka K, Sakata K, Sonomoto K, Lin L, Nakano K, T anaka Y.
IL-6/ST AT 3 signaling pathway contributes to chodrogenic differentiation of human mesenchymal stem cells.
Arthritis Rheum
T anaka Y, Hirata S, Kubo S, Fukuyo S, Hanami K, Sawamukai N, Nakano K, Nakayamada S, Yamaoka K, Sawamura F, Saito K.
Discontinuation of adalimumab after achieving remission in patients with established rheumatoid arthiritis: 1-year outcome of the HONOR study.
Ann Rheum Dis
Ishizaki J, Saito K, Nawata M, Mizuno Y, T okunaga M, Sawamukai N, T amura M, Hirata S, Yamaoaka K, Hasegawa H, T anaka Y.
Low complements and high titer of anti-Sm antibody as predictors of histopathologically proven silent lupus nephritis without abnormal urinalysis in patients with systemic lupus erythematosus.
Rheumatology
Iwata S, Yamaoaka K, Niiro H, Jabbarzadeh-T abrizi S, Wang S-P, Kondo M, Yoshikawa M, Akashi K, T anaka, Y.
Increased Syk phosphorylation leads to overexpression of T RAF6 in peripheral B cells of patients with systemic lupus erythematosus.
Lupus
T anaka Y, Martin Mola E.
Can IL-6-targeting catch up T NF-targeting in rheumatoid arthritis: from studies of olokizumab, sarilumab and sirukumab.
Ann Rheum Dis 73 1395-1397 2014
Kubo S, Yamaoka K, Kondo M, Yamagata K, Zhao J, Iwata S, T anaka Y.
T he JAK inhibitor tofacitinib reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells.
Ann Rheum Dis 73 2192-2198 2014
in press
田 中 良 哉 藤 尾 圭 志
in press in press
Epub ahead of print
Epub ahead of print
Epub ahead of print
in press
Wang S-P, Iwata S, Nakayamada S, Sakata K, Yamaoka K, T anaka Y.
T ofacitinib, a Jak inhibitor, inhibits human
B cell activation in vitro. Ann Rheum Dis 73 2213-2215 2014
Fukuyo S, Yamaoka K, Sonomoto K, Oshita K, Okada Y, Saito K, Yoshida Y, Kanazawa T , Minami Y, T anaka Y.
IL-6-accelerated calcification by induction of ROR2 in human adipose tissue-derived mesenchymal stem cells is ST AT 3- dependent.
Rheumatology 53 1282-90 2014
T anaka Y.
Next stage of RA treatment: T NF-inhibitor- free remission will be a possible treatment goal?
Ann Rheum Dis 72 ii124-ii127 2013
T akeuchi T , Yamanaka H, Ishiguro N, Miyasaka N, Mukai M, Matsubara T , Uchida S, Akama H, Kupper H, Aprora V, T anaka Y.
Adalimumab a human anti-T NF monoclonal antibody, outcome study for the prevention of joint damage in Japanese patients with early rheumatoid arthritis: the HOPEFUL 1 study.
Ann Rheum Dis 72 1488-1495 2013
van der Heijde D, T anaka Y, Fleischmann R, et al. and the ORAL Scan investigators.
T ofacitinib (CP-690,550) in patients with rheumatoid arthritis on methotrexate: 12 month data from a 24 month Phase 3 randomized radiographic study.
Arthritis Rheum 65 559-570 2013
Iwata S, Saito K, T okunaga M, T anaka Y.
Persistent memory B cell down-regulation after 6-year remission induced by rituximab therapy in patients with systemic lupus erythematosus.
Lupus 22 538-540 2013
Iwata S, Saito K, T okunaga M, T anaka Y.
B-cell or T -cell-dominant recurrence after
rituximab therapy in patients with SLE. Ann Rheum Dis 71 1749-55 2012
T anaka Y, Maeshima Y, Yamaoaka K. In vitro and in vivo analysis of a Jak
inhibitor in rheumatoid arthritis. Ann Rheum Dis 71 i70-i74 2012
Maeshima K, Yamaoaka K Kubo s, Nakano K, Iwata S, Saito K, Ohishi M, Miyahara H, T anaka S, Ishi K, Yoshimatsu H, T anaka Y.
A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN- and IL-17 production by human CD4+ T cells.
Arthritis Rheum 64 1790-98 2012
Sonomoto K, Yamaoka K, Oshita K, Fukuyo S, Zhang X, Nakano K, Okada Y, T anaka Y.
IL-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt5a/Ror2 pathway.
Arthritis Rheum 64 3353-63 2012
T anaka Y. Intensive treatment and treatment holiday of T NF-inhibitors in rheumatoid arthritis.
Curr Opin
Rheumatol 24 319-326 2012
T anaka Y, Harigai M, T akeuchi T , Yamanaka H, Ishiguro N, Yamamoto K, Mitasaka N, Koike T , Kanazawa M, Oba T , Yoshinari T , Baker D and the GO- FORT H study group.
Golimumab, a human anti-T NF-α monoclonal antibody, injected subcutaneously every 4 weeks in Japanese patients with active rheumatoid arthritis in combination with methotrexate.
Ann Rheum Dis 71 817-824 2012
Iwata S, Yamaoka K, Niiro H, Nakano K, Wang S-P, Akashi K, T anaka Y.
Amplification of toll-like receptor-mediated signaling through Syk in human B cell activation.
J Allergy Clin
Immunol 129 1594-1601 2012
田
中
良
哉
Nakamura H, T akahashi Y, Yamamoto- Fukuda T , Horai Y,Nakashima Y, Arima K, Nakamura T , Koji T , and Kawakami A.
Direct infection of primary salivary gland epithelial cells by HT LV-Ⅰ that induces the niche of the salivary glands of sjogren’s syndrome patients.
Arthritis Rheumatol 2015
Horai Y, Koga T , Fujikawa K, T akatani A, Nishino A, Nakashima Y, Suzuki T , Kawashiri SY, Iwamoto N, Ichinose K, T amai M, Nakamura H, Ida H, Kakugawa T , Sakamoto N, Ishimatsu Y, Mukae H, Hamaguchi Y, Fujimoto M, Kuwana M, Origuchi T , Kohno S, Kawakami A.
Serum interferon-α is a useful biomarker in patients with anti-melanoma
differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis.
Mod Rheumatol. 25 Sep-85 2015
Migita K, Izumi Y, Jiuchi Y, Kozuru H, Kawahara C, Izumi M, Sakai T , Nakamura M, Motokawa S, Nakamura T , Kawakami A
Effects of Janus kinase inhibitor tofacitinib on circulating serum amyloid A and interleukin-6 during treatment for rheumatoid arthritis.
Clin Exp Immunol 175 208-14 2014
Kawashiri SY, Ueki Y, T erada K, Yamasaki S, Aoyagi K, Kawakami A.
Improvement of plasma endothelin-1 and nitric oxide in patients with systemic sclerosis by bosentan therapy.
Rheumatol Int 34 221-5 2014
岩本 直樹, 川上 純.
【自己免疫性血液疾患:診断と治療の 進歩】病態の基礎 自己抗体の産生 機序.
日本内科学会雑誌 103 1564-69 2014
一瀬邦弘, 川上 純.
最新関節リウマチ学 ―寛解・治癒を 目指した研究と最新治療― Ⅲ.関節リ ウマチの発症要因と発症メカニズム T h17細胞.
日本臨牀 72 Aug-53 2014
Kuriya G, Uchida T , Akazawa S, Kobayashi M, Nakamura K, Satoh T , Horie I, Kawasaki E, Yamasaki H, Yu L, Iwakura Y, Sasaki H, Nagayama Y, Kawakami A, Abiru N.
Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse.
Diabetologia 56 1773-80 2013
Kobayashi M, Kaneko-Koike C, Abiru N, Uchida T , Akazawa S, Nakamura K, Kuriya G, Satoh T , Ida H, Kawasaki E, Yamasaki H, Nagayama Y, Sasaki H, Kawakami A.
Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice.
Clin Exp Immunol 173 411-8 2013
Ohyama K, Kawakami A, T amai M, Baba M, Kishikawa N, Kuroda N.
Serum immune complex containing thrombospondin-1: a novel biomarker for early rheumatoid arthritis.
Ann Rheum Dis 71 1916-17 2012
Koga T , Fujikawa K, Horai Y, Okada A, Kawashiri SY, Iwamoto N, Suzuki T , Nakashima Y, T amai M, Arima K, Yamasaki S, Nakamura H, Origuchi T , Hamaguchi Y, Fujimoto M, Ishimatsu Y, Mukae H, Kuwana M, Kohno S, Eguchi K, Aoyagi K, Kawakami A.
T he diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM.
Rheumatology
(Oxford) 51 1278-84 2012
in press
川
上
純
2012-2014年度 （関連書籍）
著者氏名 タイトル 書籍名 編集者名 出版社名・地 頁
小竹 茂 関節リウマチ 病態
第３版Evidence Based Medicineを活
かす膠原病・リウマ チ診療
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MEDICAL VIEW 東京 2013年
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小竹 茂 脊椎関節炎
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MEDICAL VIEW 東京 2013年
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小竹 茂、小橋川剛 Behcet病
第３版Evidence Based Medicineを活
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MEDICAL VIEW 東京 2013年
476-499
田村直人 免疫抑制薬 竹内 勤
関節リウ マチ治療 実践バイ ブル
南江堂 101-6
田村直人，多田久里守 付着部炎と骨新生
七川歡次，編集 前 田 晃，吉川秀樹，塩
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熊ノ郷淳，福田眞 輔，志水正敏，村田
紀和，西林保郎 リウマチ
病セミ ナーXX
Ⅴ
永井書店 1-7
