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1.Gold-thioglucoseߣ high fat diet ߦߡߒߚ 㕖ࠕ࡞ࠦ࡞ᕈ⢽⢌⢄Ἳ㧔NASH㧕model mouse
ዊ═ේశᚑ ᶖൻེౝ⑼ 㧝㧚⎇ⓥߩ⢛᥊ߣ⋡⊛
㕖ࠕ࡞ࠦ࡞ᕈ⢽⢌⢄Ἳ㧔non-alcoholic steatohepatitis ; NASH㧕ߪޔవㅴ࿖ࠍਛᔃߣߒߚ⇇ߦ ߅ߡޔ⢄⎬ᄌޔߐࠄߦߪ⢄⚦⢩≸߳ߣㅴⴕߔࠆ㊀ⷐߥᘟᕈ⢄Ἳߣߒߡ⍮ࠄࠇߡࠆޕߒ߆ߒޔ㕖ࠕ ࡞ࠦ࡞ᕈ⢽⢌⢄Ἳߩᯏᐨ⸃ޔᴦ≮ᴺߩ⎇ⓥߦ߅ߡߪޔ⢈ḩޔࠗࡦࠬࡦᛶ᛫ᕈޔ⢄ߩ⢽⢌ൻޔ ⢄⚦⢩㓚ኂޔ✢⛽ൻ╬ߔߴߡࠍḩߚߔࠃ߁ߥേ‛ࡕ࠺࡞߇⏕┙ߐࠇߡߥߣ߁ߩ߇⁁ߢࠆޕ ߘߎߢᚒޘߪޔⷞᐥਅㇱߦ↪ߒㆊ㘩ߣߥࠅޔ⢈ḩࠍᒁ߈ߎߔ gold-thioglucose ᛩਈࠍࡑ࠙ࠬߦⴕ ޔߐࠄߦ㜞⢽⢌㘩ࠍਈ߃ࠆߎߣߦࠃࠅޔࡕ࠺࡞ࡑ࠙ࠬࠍᚑߒޔᚑੱ㕖ࠕ࡞ࠦ࡞ᕈ⢽⢌⢄Ἳߩ∛ ᘒߦ㘃ૃߒߚ∛ᘒ߇ࠄࠇࠆ߆ޔᬌ⸛ࠍⴕߞߚޕ 㧞㧚ᣇᴺ ታ㛎േ‛ߣߒߡ C57BL/6 ࡑ࠙ࠬࠍ↪ޔgold-thioglucose ࠍ⣻⣧ౝᛩਈߒޔㆊ㘩ࡑ࠙ࠬࠍߒߚޕ ߘߒߡޔ㘩㙄ߣߒߡ㜞⢽⢌㘩ࠍ 12 ㅳᛩਈߒޔ㕖ࠕ࡞ࠦ࡞ᕈ⢽⢌⢄Ἳ߇⺃ዉߐࠇߚ߆⸃ᨆࠍⴕ߁ߚ ߦޔേ‛ታ㛎↪ CT ߦࠃࠆ⢽⢌㊂╬ߩ᷹ቯ߿⚵❱ቇ⊛ޔ↢ൻቇ⊛ޔಽሶൻቇ⊛ߥᬌ⸛ࠍⴕߞߚޕ 㧟㧚⚿ᨐ gold-thioglucose ࠍᛩਈߖߕㅢᏱ㘩ߩߺࠍਈ߃ߚ⟲ࠍࠦࡦ࠻ࡠ࡞⟲ߣߒޔ߹ߚޔgold-thioglucose ࠍ ᛩਈߖߕ㜞⢽⢌㘩ߩߺࠍਈ߃ߚ⟲ߣߩᲧセ߽ⴕߞߚޕgold-thioglucose ߣ㜞⢽⢌㘩ࠍߣ߽ߦᛩਈߒߚ⟲ ߢߪޔ⪺ߦ㊀߇Ⴧടߒޔౝ⤳⢽⢌Ⴧടࠍ߁⢈ḩ߇ࠄࠇߚޕ߹ߚޔⴊᷡ࠻ࡦࠬࠕࡒ࠽ ߪ⪺ߦߒޔ♧⽶⩄⹜㛎߿ࠗࡦࠬࡦ⽶⩄⹜㛎ߦ߅ߡޔ⠴♧⢻⇣Ᏹ߿ࠗࡦࠬࡦᛶ᛫ᕈ߽ ࠄࠇߚޕ gold-thioglucose ߣ㜞⢽⢌㘩ࠍߣ߽ߦᛩਈߒߚ⟲ߢߪޔ㕖ࠕ࡞ࠦ࡞ᕈ⢽⢌⢄Ἳߦ․ᓽ⊛ߥ⚵❱߇ ࠄࠇߚޕ ༀ₹ࠨࠗ࠻ࠞࠗࡦߣ⸒ࠊࠇࠆⴊᷡࠕ࠺ࠖࡐࡀࠢ࠴ࡦߪૐਅߒޔ߹ߚޔߘߩࡊ࠲ߢࠆࠕ࠺ࠖ ࡐࡀࠢ࠴ࡦࡊ࠲1, 2㧔AdipoR1, R2㧕ߩ⢄ߢߩ mRNA ⊒ߪૐਅߒߡߚޕߐࠄߦޔPPAR-ǫ߿
FASߣߞߚ⢽⾰วᚑ♽ߩࡑࠞߩ mRNA ⊒ߪ⢄ߦ߅ߡჇടߒߡߚޕ 㧠㧚߹ߣ gold-thioglucose ߣ㜞⢽⢌㘩ߩᛩਈࠍⴕߞߚࡑ࠙ࠬߪޔ⍴ᦼ㑆ߢࡔ࠲ࡏ࠶ࠢࠪࡦ࠼ࡠࡓߦ߅ߡ ࠄࠇࠆ⢄∛ᄌߣห᭽ߩ∛ᘒࠍᓧࠆߎߣ߇น⢻ߢޔߐࠄߦ↢ൻቇ⊛ޔ⚵❱ቇ⊛ޔಽሶൻቇ⊛⇣Ᏹ߽ ߁ᚑੱ㕖ࠕ࡞ࠦ࡞ᕈ⢽⢌⢄Ἳߦ㘃ૃߒߚേ‛ࡕ࠺࡞ߣ⠨߃ࠄࠇߚޕߎߩࡕ࠺࡞ࡑ࠙ࠬࠍ↪ࠆߎߣ ߦࠃࠅޔᓟޔ㕖ࠕ࡞ࠦ࡞ᕈ⢽⢌⢄Ἳߩ⚦ߥᯏᐨߩ⸃߿ޔᴦ≮ᴺ㐿⊒ߩ৻ഥߦߥࠅ߁ࠆߣ⠨߃ ࠄࠇߚޕ