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業績集 : 滋賀医科大学 内科学講座 呼吸循環器内科 第三代 堀江教授業績(2)循環器内科 英文雑誌2003~2014

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業績集 : 滋賀医科大学 内科学講座 呼吸循環

器内科 第三代 堀江教授業績(2)循環器内科 

英文雑誌2003∼2014

著者

滋賀医科大学 内科学講座 呼吸循環器内科

発行年

2014-08-04

URL

http://hdl.handle.net/10422/7176

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滋賀医科大学

内科学講座

呼吸循環器内科

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英文雑誌 【2014】

 Hasegawa K, Ohno S, Ashihara T, Itoh H, Ding WG, Toyoda F, Makiyama T, Aoki H, Nakamura Y, Delisle BP, Matsuura H, Horie M. A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels. Heart Rhythm. 11(1): 67-75, 2014.

 Hayashi H, Miyamoto A, Kawaguchi T, Naiki N, Xue J, Murakami Y, Horie M. P Pulmonale and the Development of Atrial Fibrillation. Circulation Journal 78(2): 329-37, 2014.

 Kato K, Makiyama T, Wu J, Ding WG, Kimura H, Naiki Nobu, Ohno Seiko, Itoh H, Nakanishi T, Matsuura H, Horie M. Cardiac Channelopathies Associated With Infantile Fatal Ventricular Arrhythmias, From The Cradle to The Bench. J Cardiovasc Electrophysiol 25(1): 66-73, 2014.

 Wang Q, Ohno S, Ding WG, Fukuyama M, Miyamoto A, Itoh H, Makiyama T, Wu J, Bai J, Hasegawa K, Shinohara T, Takahashi N, Shimizu A, Matsuura H, Horie M. Gain-of-Function KCNH2 Mutations in Patients with Brugada Syndrome. J Cardiovasc Electrophysiol. 25(5):522-30, 2014

 Ohno S, Omura M, Kawamura M, Kimura H, Itoh H, Makiyama T, Ushinohama H, Makita N, Horie M. Exon-3 Deletion of RYR2 Encoding Cardiac Ryanodine Receptor is Associated with Left Ventricular Non-Compaction. Europace

0(0)1-9,2014

 Kokunai Y, Nakata T, Furuta M, Sakata S, Kimura H, Aiba T, Yoshinaga M, Osaki Y, Nakamori M, Itoh H, Sato T, Kubota T, Kadota K, Shindo K, Mochizuki H, Shimizu W, Horie M, Okamura Y, Ohno K, Takahashi MP. A Kir3.4 mutation causes Andersen – Tawil syndrome by an inhibitory effect on Kir2.1.

Neurology.82(12):1058-64, 2104

 Sakata S, Kurata Y, Li P, Notsu T, Morikawa K, Miake J, Higaki K, Yamamoto Y, Yoshida A, Shirayoshi Y, Yamamoto K, Horie M, Ninomiya H, Kanzaki S, Hisatome I. Instability of KCNE1-D85N that causes long QT syndrome: stabilization by verapamil. PACE (in press)

 Zhou J, Ding WG, Makiyama T, Miyamoto A, Matsumoto Y , Kimura H, Tarutani Y, Zhao J, Wu J, Zang WJ, Matsuura H, Horie M. A Novel HCN4 Mutation, G1097W, is associated with atrioventricular block. Circulation Journal.78(4):938-42, 2014

 Hayashi H, Kawaguchi T, Horie M. Effect of Flecainide on T-wave Alternans in Andersen-Tawil Syndrome. Annals of Noninvasive Electrocardiology (in press)  Araki A, Katsuno M, Suzuki K, Banno H, Suga N, Hashizume A, Mano T, Hijikata Y,

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Nakatsuji H, Watanabe H, Makiyama T, Ohno S, Fukuyama M, Morimoto S, Horie M, Sobue G. Brugada syndrome in spinal and bulbar muscular atrophy (SBMA).

Neurology 82(20):1813-21,2014

 Hasegawa K, Ohno S, Kimura H, Itoh H, Makiyama T, Yoshida Y, Horie M. Mosaic KCNJ2 Mutation in Andersen-Tawil syndrome: Targeted Deep Sequencing is Useful for the Detection of Mosaicism. Clinical Genetics (in press)

 Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Okuda N, Yoshita K, Kita Y, Murakami Y, Nakamura Y, Okamura T, Horie M. A high dietary long-chain n-3 fatty acids intake attenuates the effect of a high resting heart rate on the risk of cardiovascular mortality: A 24-year follow-up of the Japanese general population. Journal of Cardiology.S0914-5087(14)00023-9, 2014

 Katsuumi G, Shimizu W, Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. International journal of cardiology ;172(2):519-22, 2014.

 Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Kato M, Suwa S, Takizawa A, Takatsu Y, Shinoda E, Eizawa H, Takeda T, Lee JD, Inoko M, Ogawa H, Hamasaki S, Horie M, Nohara R, Kambara H, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T; on behalf of the CREDO-Kyoto PCI/CABG registry cohort-2 investigators. Late Adverse Events After Implantation of Sirolimus-Eluting Stent and Bare-Metal Stent: Long-Term (5-7 Years) Follow-Up of the Coronary Revascularization Demonstrating Outcome Study-Kyoto Registry Cohort-2. Circ Cardiovasc Interv. 7(2):168-79,2014

 Wu J, Naiki N, Ding WG, Ohno S, Kato K, Zang WJ, Delisle BP, Matsuura H, Horie M. A molecular mechanism for adrenergic-induced long QT Syndrome. J Am Coll Cardiol.63(8)819-27,2014

 Yoshinaga M, Kucho Y, Sarantuya J, Ninomiya Y, Horigome H, Ushinohama H, Shimizu W, Horie M. Genetic characteristics of children and adolescents with long QT syndrome diagnosed by school-based electrocardiographic screening programs.

Circulation Arrhythmia and Electrophysiol 7: 107-12, 2014.

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Burgess DE, Delisle BP. A KCNQ1 Mutation Contributes to the Concealed Type 1 Long QT Phenotype by Limiting the Kv7.1 Channel Conformational Changes Associated with PKA Phosphorylation. Heart Rhythm 11(3): 459-68, 2014.

 Fukuyama M, Ohno S, Wang Q, Shirayama T, Itoh H, Horie M. Nonsense-mediated mRNA decay due to a CACNA1C splicing mutation in a patient with Brugada syndrome. Heart Rhythm 11(4):629-34, 2014.

 Fukuyama M, Qi Wang, Kato K, Ohno S, Wei-Guang Ding, Toyoda F, Itoh H, Kimura H, Makiyama T, Ito M, Matsuura H, Horie M. Long QT syndrome Type8: novel CACNA1C mutations causing QT prolongation and variant phenotypes.

Europace 0(0)1-10,2014.

 Abe Y, Sumitomo N, Okuma H, Nakamura T, Fukuhara J, Ichikawa R, Matsumura M, Miyashita M, Kamiyama H, Ayusawa M, Watanabe M, Joo K, Makita N, Horie M. Successful control of life-threatening polymorphic ventricular tachycardia by radiofrequency catheter ablation in an infant. Heart Vessels 29(3):422-6, 2014.  Hasegawa K, Ohno S, Itoh H, Makiyama T, Aiba T, Nakano Y, Shimizu W,

Matsuura H, Horie M. A rare KCNE1 polymorphism, D85N, as a genetic modifier of long QT syndrome. Journal of Arrhythmia 30(3):161-166,2014

 Nakatsuma k, Shiomi H, Watanabe H, Morimoto T, Taniguchi T, Toyota T, Furukawa Y, Nakagawa Y, Horie M, Kimura T, on behalf of the CREDO-Kyoto AMI investigators.Comparison of Long-term Mortality After Acute Myocardial Infarction Treated by Percutaneous Coronary Intervention in Patients Living Alone versus Not Living Alone at the Time of Hospitalizatio(in press)

 Goto K, Nakai K, Shizuta S, Morimoto T, Shiomi H, Natsuaki M, Yahata M, Ota C, Ono K, Makiyama T, Nakagawa Y, Furukawa Y, Kadota K, Takatsu Y, Tamura T, Takizawa A, Inada T, Doi O, Nohara R, Matsuda M, Takeda T, Kato M, Shirotani M, Eizawa H, Ishii K, Lee JD, Takahashi M, Horie M, Takahashi M, Miki S, Aoyama T, Suwa S, Hamasaki S, Ogawa H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, CREDO-Kyoto Registry Cohort-2 Investigators. Anticoagulant and Antiplatelet Therapy in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention The American Journal of Cardiology 114(1) 70-78, 2014.

 Fujii K, Ozeki Y, Okayasu H, Takano Y, Shinozaki T, Hori H, Orui M, Horie M, Kunugi H, Shimoda K. QT Is Longer in Drug-Free Patients with Schizophrenia Compared with Age-Matched Healthy Subjects. PLoS One 9(6):e98555.1-6,2014  Watanabe E, Tanabe T, Osaka M, Chishaki A, Takase B, Niwano S, Watanabe I,

Sugi K, Katoh T, Takayanagi K, Mawatari K, Horie M, Okumura K, Inoue H, Atarashi H, Yamaguchi I, Nagasawa S, Moroe K, Kodama I, Sugimoto T, Aizawa Y.

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Sudden cardiac arrest recorded during Holter monitoring: Prevalence, antecedent electrical events, and outcomes. Heart Rhythm S1547-5271(14)00498-6,2014

【2013】

 Villafane J, Atallah J, Gollob MH, Maury P, Wolpert C, Gebauer R, Watanabe H, Horie M, Anttonen O, Kannankeril P, Faulknier B, Bleiz J, Makiyama T, Hamilton R, Young M-L. Long Term Follow-up of a Pediatric Cohort with Short QT Syndrome.

J Am Coll Cardiol. 61(11): 1183-91, 2013.

 Wu J, Ding WG, Zhao J, Zang WJ, Matsuura H, Horie M. Irbesartan-mediated AT1 receptor blockade attenuates hyposmostic-induced enhancement of IKs current and prevents shortening of action potential duration in atrial myocytes. the Journal of the Renin-Angiotensin-Aldosterone System. 0(0)1-7,2013

 Nakano Y, Chayama K, Ochi H, Toshisige M, Hayashida Y, Miki D, Hayes C. N, Suzuki H, TokuyamaT, Oda N, Suenari K, Uchimura-MakitaY, KajiharaK, Sairaku A, Motoda C, Fujiwara M, WatanabeY, YoshidaY, Ohkubo K, Watanabe I, Nogami A, Hasegawa K, Watanabe H, Endo N, Aiba T, Shimizu W, Ono S, Horie M, Arihiro K, Tashiro S, Makita N, Kihara Y. A nonsynonymous polymorphism in Semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. PLOS Genetics 9(4): e1003364, 2013.

 Wang Q, Ohno S, Kato K, Fukuyama M, Makiyama T, Kimura H, Naiki N, Kawamura M, Hayashi H, Horie M. Genetic Screening of KCNJ8 in Japanese Patients with J-wave Syndromes or Idiopathic Ventricular Fibrillation. Journal of Arrhythmia 29: 261-264, 2013.

 Ohno S, Nagaoka I, Fukuyama M, Kimura H, Itoh H, Makiyama T, Shimizu A, Horie M. Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/ dysplasia. Circulation Journal 77(6): 1534-1542, 2013.

 Duchatelet S, Crotti L, Peat R, Denjoy I, Itoh H, Berthet M, Ohno S, Fressart V, Monti C, Crocamo C, Pedrazzini M, Dagradi F, Vicentini A, Klug D, Brink P, Goosen A, Heikki S, Toivonen L, Lahtinen A, Kontula K, Shimizu W, Horie M, George Jr. AL, Tregouet DA, Guicheney P, Schwartz PJ. Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long QT syndrome. Circulation Cardiovasc Genet 6(4): 354-61, 2013.

 Takagi M, Aonuma K, Sekiguchi Y, Yokoyama Y, Aihara N, Hiraoka M, FHRS. The prognostic value of early repolarization (J wave) and ST- segment morphology after J wave in Brugada syndrome: Multicenter study in Japan. Heart Rhythm 10(4):

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533-539, 2013.

 Dochi K, Watanabe H, Kawamura M, Miyamoto A, Ozawa T, Nakazawa Y, Ashihara T, Ohno S, Hayashi H, Ito M, Sakazaki H, Kawata H, Ushinohama H, Kaszynski RH, Minamino T, Sumitomo N, Shimizu W, Horie M. Flecainide reduces ventricular arrhythmias via different actions from β -blockers in catecholaminergic polymorphic ventricular tachycardia. Journal of Arrhythmia 29: 255-260, 2013.  Fukuyama M, Ohno S, Wang Q, Kimura H, Makiyama T, Itoh H, Ito M, Horie M.

L-type calcium channel mutations in Japanese patients with inherited arrhythmias.

Circulation Journal 77(7): 1799-1806, 2013.

 Kawamura M, Ohno S, Naiki N, Nagaoka I, Dohchi K, Wang Q, Hasegawa K, Kimura H, Miyamoto A, Mizusawa Y, Itoh H, Makiyama T, Sumitomo N, Ushinohama H, Oyama K, Murakoshi N, Aonuma K, Horigome H, Honda T, Yoshinaga M, Ito M, Horie M. Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan. Circulation Journal 77(7): 1705-1713, 2013.

 Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa A, Kadota A, Takashima N, Nagasawa S, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H. The Association between J-point elevation and death from coronary heart disease: a 15-year follow-up of the NIPPON DATA90. Circulation Journal

77(5): 1260-1266, 2013.

 Aizawa Y, Chinushi M, Hasegawa K, Naiki N, Horie M, Kaneko Y, Kurabayashi M, Ito S, Imaizumi T, Aizawa Y, Takatsuki S, Joo K, Sato M, Ebe K, Hosaka Y, Haissaguerre M, Fukuda K. Electrical storm in idiopathic ventricular fibrillation is associated with early repolarization. J Am Coll Cardiol. 62(11):1015-1019, 2013.  Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota

A, Takashima N, Okuda N, Matsumura Y, Yoshita K, Kita Y, Murakami Y, Okamura T, Horie M, Okayama A, Ueshima H for the NIPPON DATA80 Research Group. Interaction of Dietary n-3 Fatty Acids and J-point Elevation on Cardiac Mortality Risk in Japanese Men: A 24-Year Follow-Up of NIPPON DATA80. Heart

99(14): 1024-1029, 2013.

 Watanabe H, van der Werf C, Roses-Noguer F, Adler A, Sumitomo N, Veltmann C, Rosso R, Bhuiyan ZA, Bikker H, Kannankeril PJ, Horie M, Minamino T, Viskin S, Knollmann BC, Till J, Wilde AA. Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 10: 542-547, 2013.

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 Horie M, Ohno S. Genetic basis of Brugada syndrome. Journal of Arrhythmia 29: 71–76, 2013.

 Tazaki J, Shiomi H, Morimoto T, Imai M, Yamaji K, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T, Kimura T. Three-year outcome after percutaneous coronary intervention and coronary artery bypass grafting in patients with triple vessel coronary artery disease: observations from the CREDO-Kyoto PCI/CABG registry cohort-2. EuroIntervention 9(4):437-45, 2013.  Morikami Y, Natsuaki M, Morimoto T, Ono K, Nakagawa Y, Furukawa Y, Sakata R,

Aota M, Okada Y, Onoe M, Kawasuji M, Koshiji T, Nakajima H, Nishizawa J, Yamanaka K, Yamamoto H, Kimura T; CREDO-Kyoto PCI/CABG registry cohort-2 investigators. Impact of polyvascular disease on clinical outcomes in patients undergoing coronary revascularization: An observation from the CREDO-Kyoto Registry Cohort-2. Atherosclerosis 228(2): 426-431, 2013.

 Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T. Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture.

Circ J. 77(5): 1307-14, 2013.

 Nakae I, Hayashi H, Mitsunami K, Horie M. Clinical significance of lung iodine-123 metaiodobenzylguanidine uptake assessment in Parkinson's and heart diseases.

Ann Nucl Med. 27(8): 737–747, 2013.

 Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Marec HL, Wilde AA, Probst V, Schott JJ, Dina C, Redon R. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nature Genetics 45(9): 1044-9, 2013.

 Hayashi H, Murakami Y, Horie M. Pitfall of the meta-analysis regarding early repolarization pattern. J Am Coll Cardiol. 62(1): 86, 2013.

 Smith JL, Reloj AR, Nataraj PS, Bartos DC, Schroder EA, Moss AJ, Ohno S, Horie M, Anderson CL, January CT, Delisle BP. Pharmacological Correction of Long

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QT-linked Mutations in KCNH2 (hERG) Increases the Trafficking of Kv11.1 Channels Stored in the Transitional ER. American Journal of Physiology-Cell Physiology 305(9):C919-30, 2013.

 Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A. Novel SCN3B Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.5. Circulation Journal 77: 959-967, 2013.

 Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa A, Kadota A, Takashima N, Nagasawa S, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H. Is more aggressive prevention of coronary artery disease required for patients with early repolarization syndrome?--Reply. Circulation Journal 77: 1643, 2013.

 Kawaguchi T, Hayashi H, Naiki N, Sakai H, Yamamoto T, Fujita M, Horie M. Spontaneous coronary artery spasm accidentally detected by 320-row multi-detector computed tomography . Journal of Cardiology Cases

8(2):e85-e87,2013

 Ichiro Nakae , Hideki Hayashi , Kenichi Mitsunami , Minoru Horie.Clinical signi?cance of lung iodine-123 metaiodobenzylguanidineuptake assessment in Parkinson’s and heart diseases. Ann Nucl Med 27: 737-47,2013.

 Barc J, Bezzina C, Mizusawa Y, Remme C, Gourraud J, Verkerk A, Schwartz P, Guicheney P, Antzelevitch C, Schulze-Bahr E, Behr E, Tfelt-Hanson J, Kaab S, Watanabe H, Horie M, Makita N, Shimizu W, Roden D, Christoffels V, Gessler M, Wilde A, Probst V, Schott J, Dina C, Redon R. Genome-wide association analysis identifies 3 common variants predisposing to brugada syndrome, a rare disease with high risk of sudden cardiac death. Heart Rhythm. 10(11): 1743-4, 2013.

 Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C. HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes: Document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm. 10(12): 1932-63, 2013.

 Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C; Document Reviewers, Ackerman M, Belhassen B, Estes NA 3rd, Fatkin D, Kalman J, Kaufman E, Kirchhof P,

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Schulze-Bahr E, Wolpert C, Vohra J, Refaat M, Etheridge SP, Campbell RM, Martin ET, Quek SC. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Europace. 15(10): 1389-406, 2013.

 Hayashi H, Shibukawa T, Horie M. Restoration of aberrant conduction induced by premature ventricular contractions. Intern Med. 52(12):1425, 2013.

【2012】

 Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Ozawa T, Ito M, Horie M, Trayanova NA: The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation implications for electrogram-based catheter ablation. Circ Res. 110(2): 275-284, 2012.

 Ijiri T, Ashihara T, Umetani N, Igarashi T, Haraguchi R, Yokota H, Nakazawa K: A kinematic approach for efficient and robust simulation of cardiac beating motion.

PLoS ONE. 7(5): e36706, 2012.

 Yamazaki M, Honjo H, Ashihara T, Harada M, Sakuma I, Nakazawa K, Trayanova N, Horie M, Kalifa J, Jalife J, Kamiya K, Kodama I: Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts.

Heart Rhythm. 9(1): 107-114, 2012.

 Kato S, Honjo H, Takemoto Y, Takanari H, Suzuki T, Okuno Y, Opthof T, Sakuma I, Inada S, Nakazawa K, Ashihara T, Kodama I, Kamiya K: Pharmacological blockade of IKs destabilizes spiral-wave reentry under β-adrenergic stimulation in favor of its early termination. J Pharmacol Sci. 119(1): 52-63, 2012.

 Miyamoto A, Hayashi H, Yoshino T, Kawaguchi T, Taniguchi A, Ito H, Sugimoto Y, Ito M, Makiyama T, Xue JQ, Murakami Y, Horie M: Clinical and electrocardiographic characteristics of patients with short QT interval in a large hospital-based population. Heart Rhythm. 9(1): 66-74, 2012.

 Shizuta S, Ando K, Nobuyoshi M, Ikeda T, Yoshino H, Hiramatsu S, Kazatani Y, Yamashiro K, Okajima K, Kajiya T, Kobayashi Y, Kato T, Fujii S, Mitsudo K, Inoue K, Ito H, Haruna Y, Doi T, Nishio Y, Ozasa N, Nishiyama K, Kita T, Morimoto T, Kimura T, for the PREVENT-SCD Investigators: Prognostic utility of T-wave alternans in a real-world population of patients with left ventricular dysfunction: the PREVENT-SCD study. Clin Res Cardiol. 101(2): 89-99, 2012.

 Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Iguchi M, Nishio Y, Sasaki K, Itoh H, Yokode M, Kita T, Horie M, Kimura T: A novel gain-of-function KCNJ2

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mutation associated with short QT syndrome impairs inward rectification of Kir2.1 currents. Cardiovasc Res. 93(4): 666-673, 2012.

 Makita N, Seki A, Sumitomo N, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR., Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AAM, Probst V, Marec HL, Delmar M, Roden DM, Mochizuki N, Schott JJ: A Connexin 40 mutation associated with a malignant variant of familial progressive heart block type-1. Circ Arrhythm Electrophysiol. 5(1): 163-172, 2012.  Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Iwabuchi M,

Shizuta S, Tomohisa Tada T, Tazaki J, Shiomi H, Kato Y, Hayano M, Abe M, Ehara N, Mizoguchi T, Mitsuoka H, Inada T, Araki M, Kaburagi S, Taniguchi R, Eizawa H, Nakano A, Tei C, Horie M, Ogawa H, Tamura T, Shirotani M, Takahashi M, Ishii I, Tatami R, Suwa T, Takizawa A, Takahashi M, Takeda T, Nohara R, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, on behalf of the CREDO-Kyoto PCI/CABG registry cohort-2 investigators: Comparison of three-year clinical outcomes after transradial versus transfemoral percutaneous coronary intervention. Am J Cardiol. 110(7): 924-932, 2012.

 Wu J, Ding WG, Matsuura H, Horie M: Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors. Pflugers Arch.

463(4): 625-633, 2012.

 Aizawa Y, Sato A, Watanabe H, Chinushi M, Furushima H, Horie M, Kaneko Y, Imaizumi T, Okubo K, Watanabe I, Shinozaki T, Aizawa Y, Fukuda, Joo K, Haissaguerre M: Dynamicity of the J wave in idiopathic ventricular fibrillation with a special reference to pause-dependent augmentation of the J wave. J Am Coll Cardiol. 59(22): 1948-1953, 2012.

 Okayasu H, Ozeki Y, Fujii K, Takano Y, Saeki Y, Hori H, Horie M, Higuchi T, Kunugi H, Shimoda K: Pharmachotherapeutic determinants for QTc interval prolongation in Japanese patients with mood disorder. Pharmacopsychiatry. 45(7): 279-283, 2012.

 Kinoshita T, Asai T, Suzuki T, Matsubayashi K, Horie M: Time course and prognostic implications of QT interval in patients with coronary artery disease undergoing coronary bypass surgery. J Cardiovasc Electrophysiol. 23(6): 645-649, 2012.

 Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N: Response to letter

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regarding article, "Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization". Circ Arrhythm Electrophysiol. 5(2): e60-e61, 2012. 猖獗

 Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding WG, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang WJ, Ito M, Matsuura H, Horie M: Phenotype variability in patients carrying KCNJ2 mutations. Circ Cardiovasc Genet. 5: 344-353, 2012.

 Shiomi H, Morimoto T, Hayano M, Furukawa Y, Nakagawa Y, Tazaki J, Imai M, Yamaji K, Tada T, Natsuaki M, Saijo S, Funakoshi S, Nagao K, Hanazawa K, Ehara N, Kadota K, Iwabuchi M, Shizuta S, Abe M, Sakata R, Okabayashi H, Hanyu M, Yamazaki F, Shimamoto M, Nishiwaki N, Imoto Y, Komiya T, Horie M, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators: Comparison of long-term outcome after percutaneous coronary intervention versus coronary artery bypass grafting in patients with unprotected left main coronary artery disease (from the CREDO-Kyoto PCI/CABG Registry Cohort-2). Am J Cardiol. 110(7): 924-932, 2012.

 Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N: Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization. Int J Cardiol. 159(3): 238-240, 2012.

 Egashira T, Yuasa S, Suzuki T, Aizawa Y, Yamakawa H, Matsuhashi T, Ohno Y, Tohyama S, Okata S, Seki T, Kuroda Y, Yae K, Hashimoto H, Tanaka T, Hattori F, Sato T, Miyoshi S, Takatsuki S, Murata M, Kurokawa J, Furukawa T, Makita N, Aiba T, Shimizu W, Horie M, Kamiya K, Kodama I, Ogawa S, Fukuda K: Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc Res. 95: 419-429, 2012.

 Tokushige A, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Iwabuchi M, Shizuta S, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Ehara N, Inada T, Kaburagi S, Hamasaki S, Tei C, Nakashima H, Ogawa H, Tatami R, Suwa S, Takizawa A, Nohara R, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, CREDO-Kyoto PCI/CABG registry cohort-2 investigators: Incidence and outcome of surgical procedures after coronary bare-metal and drug-eluting stent implantation: a report from the CREDO-Kyoto PCI/CABG registry cohort-2. Circ Cardiovasc

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Interv. 5(2): 237-246, 2012.

 Tada T, Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Byrne RA, Kastrati A, Kadota K, Iwabuchi M, Shizuta S, Tazaki J, Shiomi H, Abe M, Ehara N, Mizoguchi T, Mitsuoka H, Inada T, Araki M, Kaburagi S, Taniguchi R, Eizawa H, Nakano A, Suwa S, Takizawa A, Nohara R, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T, on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators: Duration of dual antiplatelet therapy and long-term clinical outcome after coronary drug-eluting stent implantation: landmark analyses from the CREDO-Kyoto PCI/CABG Registry Cohort-2. Circ Cardiovasc Interv. 5(3): 381-391, 2012.

 Shiomi H, Nakagawa Y, Morimoto T, Furukawa Y, Nakano A, Shirai S, Taniguchi R, Yamaji K, Nagao K, Suyama T, Mitsuoka H, Araki M, Takashima H, Mizoguchi T, Eisawa H, Sugiyama S, Kimura T, CREDO-Kyoto AMI investigators: Association of onset to balloon and door to balloon time with long term clinical outcome in patients with ST elevation acute myocardial infarction having primary percutaneous coronary intervention: observational study. BMJ. 344: e3257, 2012.

 Takigawa M, Kawamura M, Noda T, Yamada Y, Miyamoto K, Okamura H, Satomi K, Aiba T, Kamakura S, Sakaguchi T, Mizusawa Y, Itoh H, Horie M, Shimizu W: Seasonal and circadian distributions of cardiac events in genotyped patients with congenital long QT syndrome. Circ J. 76(9): 2112-2118, 2012.

 Nakajima T, Wu J, Kaneko Y, Ashihara T, Ohno S, Irie T, Ding WG, Matsuura H, Kurabayashi M, Horie M: KCNE3 T4A as a genetic background of Brugada-pattern electrocardiogram. Circ J. 76(12): 2763-2772, 2012.

 Kawaguchi T, Hayashi H, Miyamoto A, Yoshino T, Taniguchi A, Naiki N, Sugimoto Y, Ito M, Xue J-Q, Murakami Y, Horie M: Prognostic implications of progressive cardiac conduction disease. Circ J. 77(1):60-7, 2012.

 Momomura S, Tsutsui H, Sugawara Y, Ito M, Mitsuhashi T, Fukamizu S, Noro M, Matsumoto N, Tejima T, Sugi K: Clinical efficacy of cardiac resynchronization therapy with an implantable defibrillator in a Japanese population: results of the MIRACLE-ICD outcome measured in Japanese indication (MOMIJI) study. Circ J.

76(8): 1911-1919, 2012.

 Isono T, Matsumoto T, Wada A, Suzaki M, Chano T. A global transcriptome analysis of a dog model of congestive heart failure with the human genome as a reference. J Card Fail. 18(11):872-8, 2012.

 Burgess DE, Bartos DC, Reloj AR, Campbell KS, Johnson JN, Tester DJ, Ackerman MJ, Fressart V, Denjoy I, Guicheney P, Moss AJ, Ohno S, Horie M, Delisle BP.

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High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K(+) permeation. Biochemistry 51(45):9076-85, 2012.

【2011】

 Haraguchi R, Ashihara T, Namba T, Tsumoto K, Murakami S, Kurachi Y, Ikeda T,

Nakazawa K: Transmural dispersion of repolarization determines scroll wave behavior during ventricular tachyarrhythmias. Circ J. 75(1): 80-88, 2011.

 Trayanova N, Constantino J, Ashihara T, Plank G: Modeling defibrillation of the heart:

Approaches and insights. IEEE Rev Biomed Eng. 4: 89-102, 2011.

 Takanari H, Honjo H, Takemoto Y, Suzuki T, Kato S, Harada M, Okuno Y, Ashihara T,

Opthof T, Sakuma I, Kamiya K, Kodama I: Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling. J Pharmacol Sci. 115(1): 15-26, 2011.

 Matsumoto T, Eguchi Y, Oda H, Yamane T, Tarutani Y, Ozawa T, Hayashi H, Nakae I,

Horie M, Urade Y: Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine. Circ J. 75: 897-904, 2011.

 Li P, Ninomiya H, KurataY, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K,

Toyoda F, Wu J, Horie M, Shirayoshi Y, Hiraoka M, Hisatome I: Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res. 108: 458-468, 2011.

 Miyamoto A, Hayashi H, Makiyama T, Yoshino T, Mizusawa Y, Sugimoto Y, Ito M, Xue

JQ, Murakami Y, Horie M: Risk determinants in individuals with a spontaneous type 1 Brugada ECG. Circ J. 75: 844-851, 2011.

 Matsumoto T, Horie M: Angiotensin-converting enzyme inhibition and fibrinolytic balance.

Hypertens Res. 34: 448-449, 2011.

 Nishiyama K, Tsutamoto T, Yamaji M, Kawahara C, Fujii M, Yamamoto T, Horie M:

Biological variation of brain natriuretic peptide and cardiac events in stable outpatients with nonischemic chronic heart failure. Circ J. 75: 341-347, 2011.

 Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T,

Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M: KCNE5 (KCNE1L) variants are novel modulators of brugada syndrome and idiopathic ventricular fibrillation. Circ Arrhythm Electrophysiol. 4(3): 352-361, 2011.

 Doi T, Makiyama T, Morimoto T, Haruna Y, Tsuji K, Ohno S, Akao M, Takahashi Y,

Kimura T, Horie M: A novel KCNJ2 nonsense mutation, S369X, impedes trafficking and causes a limited form of andersen-tawil syndrome. Circ Cardiovasc Genet. 4: 253-260, 2011.

 Shimizu W, Horie M: Phenotypical manifestations of mutations in genes encoding subunits

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 Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y,

Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H; Japanese Coronary Spasm Association: Clinical characteristics and long-term prognosis of vasospastic angina patients who survived out-of-hospital cardiac arrest: multicenter registry study of the Japanese Coronary Spasm Association. Circ Arrhythm Electrophysiol. 4(3): 295-302, 2011.

 Kawahara C, Tsutamoto T, Nishiyama K, Yamaji M, Sakai H, Fujii M, Yamamoto T, Horie

M: Prognostic role of high-sensitivity cardiac troponin T in patients with nonischemic dilated cardiomyopathy. Circ J. 75(3): 656-661, 2011.

 Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y: Roles of subcellular Na+

channel distributions in the mechanism of cardiac conduction. Biophys J. 100(3): 554-563, 2011.

 Nishiyama K, Tsutamoto T, Kawahara C, Yamaji M, Sakai H, Yamamoto T, Fujii M, Horie

M: Relationship between biological variation in B-type natriuretic peptide and plasma renin concentration in stable outpatients with dilated cardiomyopathy. Circ J. 75(8): 1897-1904, 2011.

 Tsuji K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Nishio Y,

Sakaguchi T, Matsuura H, Horie M: Identification and functional characterization of KCNQ1 mutations around the exon7-intron7 junction affecting the splicing process. BBA - Molecular Basis of Disease. 1812(11): 1452-1459, 2011.

 Yoshino T, Nakae I, Matsumoto T, Mitsunami K, Horie M: Association between

brachial-ankle pulse wave velocity and endothelium-dependent and -independent coronary vasomotor function. Clin Exp Pharmacol Physiol. 38(1): 34-41, 2011.

 Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T,

Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N: Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol. 4(6): 874-881, 2011.

 Kawahara C, Tsutamoto T, Sakai H, Nishiyama K, Yamaji M, Fujii M, Yamamoto T, Horie

M: Prognostic value of serial measurements of highly sensitive cardiac troponin I in stable outpatients with nonischemic chronic heart failure. Am Heart J. 162(4): 639-645, 2011.

 Funakoshi S, Furukawa Y, Ehara N, Morimoto T, Kaji S, Yamamuro A, Kinoshita M, Kitai

T, Kim K, Tani T, Kobori A, Nasu M, Okada Y, Kita T, Kimura T; CREDO-Kyoto Investigators: Clinical characteristics and outcomes of Japanese women undergoing coronary revascularization therapy. Circ J. 75(6): 1358-1367, 2011.

 Tsutamoto T, Sakai H, Ibe K, Yamaji M, Kawahara C, Nakae I, Fujii M, Yamamoto T,

Horie M: Effect of atorvastatin vs. rosuvastatin on cardiac sympathetic nerve activity in non-diabetic patients with dilated cardiomyopathy. Circ J. 75(9): 2160-2166, 2011.

 Kimura H, Mizusawa Y, Itoh H, Miyamoto A, Kawamura M, Kawaguchi T, Naiki N, Oka Y,

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effective in long QT syndrome type 2. J Arrhythm. 27; 324-331, 2011.

 Kimura T, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Tazaki J, Kato Y, Hayano M,

Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Tatami R, Suwa S, Takizawa A, Takatsu Y, Takahashi M, Kato H, Takeda T, Lee J-D, Nohara R, Tei C, Horie M, Kambara H, Fujiwara H, Mitsudo Km Nobuyoshi M, Kita T: Association of the use of proton pump inhibitors with adverse cardiovascular and bleeding outcomes after percutaneous coronary intervention in the Japanese real world clinical practice. Cardiovasc Interv Ther. 26: 222-233, 2011.

 Kimura T, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Iwabuchi M, Shizuta S,

Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Tatami R, Suwa S, Takizawa A, Takatsu Y, Takahashi M, Kato H, Takeda T, Lee JD, Nohara R, Ogawa H, Tei C, Horie M, Kambara H, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T: Long-term safety and efficacy of sirolimus-eluting stents versus bare-metal stents in real world clinicalpractice in Japan. Cardiovasc Interv Ther. 26: 234-245, 2011.

 Miyamoto A, Hayashi H, Yoshino T, Kawaguchi T, Taniguchi A, Itoh H, Sugimoto Y, Itoh

M, Makiyama T, Xue JQ, Murakami Y, Horie M: Clinical and electrocardiographic characteristics of patients with short QT interval in a large hospital-based population. Heart Rhythm. 9(1): 66-74, 2011.

【2010】

 Ozeki Y, Fujii K, Kuromoto N, Yamada N, Okawa M, Aoki T, Takahashi J, Narita M, Ishida

N, Saito O, Horie M, Kunugi H: QTc prolongation and antipsychotic medication in 1017 patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 34: 401-405, 2010.

 Tsutamoto T, Kawahara C, Nishiyama K, Yamaji M, Fujii M, Yamamoto T, Horie M:

Prognostic role of highly sensitive cardiac troponin I in patients with systolic heart failure. Am Heart J. 159: 63-67, 2010.

 Tsutamoto T, Nishiyama K, Yamaji M, Kawahara C, Fujii M, Yamamoto T, Horie M:

Comparison of the long-term effects of candesartan and olmesartan on plasma angiotensin II and left ventricular mass index in patients with hypertension. Hypertens Res. 33: 118-122, 2010.

 Wu J, Shimizu W, Ding W-G, Ohno S, Toyada F, Itoh H, Zang W-J, Miyamoto Y,

Kamakura S, Matsuura H, Nademanee J, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M: KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders. Heart Rhythm. 7: 199-205, 2010.

 Horigome H, Nagashima M, Sumitomo N, Yoshinaga M, Ushinohama H, Iwamoto M,

Shiono J, Ichihashi K, Hasegawa S, Yoshikawa T, Matsunaga T, Goto H, Waki K, Arima M, Takasugi H, Tanaka Y, Miura M, Ogawa K, Suzuki H, Yamagishi H, Ikoma M, Suda K, Takagi J, Sato J, Shimizu H, Saiki H, Hoshiai M, Ichida F, Takeda S, Takigiku K, Inamura N, Kajino H, Murakami T, Shimizu W, Horie M: Clinical characteristics and genetic

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background of congenital long QT syndrome diagnosed in fetal, neonatal and infantile life. A nation-wide questionnaire survey in Japan. Circ Arrhythm Electrophysiol. 3: 10-17, 2010.

 Ishida K, Hayashi H, Miyamoto A, Sugimoto Y, Ito M, Murakami Y, Horie M: P-wave and

the development of atrial fibrillation. Heart Rhythm. 7: 289-294, 2010.

 Matsumoto T, Fujita M, Sawamura T, Kakino A, Sato Y, Fujita Y, Matsuda H, Nakanishi M,

Uchida K, Nakae I, Kanda H, Yoshida A, Miwa K, Hayashi H, Mitsunami K, Horie M: Pitavastatin reduces Lectin-Like oxidized low-density lipoprotein Receptor-1 ligands in hypercholesterolemic humans. Lipids. 45; 329-335, 2010.

 Watanabe H, Makiyama T, Koyama T, Kannankeril PJ, Seto S, Okamura K, Oda H, Itoh H,

Okada M, Tanabe N, Yagihara N, Kamakura S, Horie M, Aizawa Y, Shimizu W: High prevalence of early repolarization in short QT syndrome. Heart Rhythm. 7: 647-652, 2010.

 Constantino J, Long Y, Ashihara T, Trayanova NA: Tunnel propagation following

defibrillation with ICD shocks: Hidden postshock activations in the left ventricular wall underlie isoelectric window. Heart Rhythm. 7(7): 953-961, 2010.

 Toyoda F, Ding W-G, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H:

Characterization of the rapidly activating delayed rectifier potassium current, IKr, in HL-1 mouse atrial myocytes. J Membr Biol. 235: 73-87, 2010.

 Yasuda S, Hiramatsu S, Odashiro K, Maruyama T, Tsuji K, Horie M: A family of hereditary

long QT syndrome caused by Q738X HERG mutation. Int J Cardiol. 144: 69-72, 2010.

 Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahata Y, Shiokawa Y, Yoshikane

Y, Makiyama T, Horie M, Hara T: A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome. Int J Cardiol. 145: 61-64, 2010.

Horie M: Bi-directional ventricular tachycardia revised. J Arrhythm. 26: 3-4, 2010.

 Itoh H, Shimizu W, Hayashi K, Yamagata K, Sakaguchi T, Ohno S, Makiyama T, Akao M,

Ai T, Noda T, Miyazaki A, Miyamoto Y, Yamagishi M, Kamakura S, Horie M: Long QT syndrome with compound mutations is associated with a more severe phenotype: A Japanese multicenter study. Heart Rhythm. 7: 1411-1418, 2010.

 Matsumoto T, Takashima H, Nakae I, Yamane T, Hayashi H, Horie M; for the SPAIC

(Shiga tissue Plasminogen Activator In Coronary circulation) Investigators: Angiotensin-converting enzyme inhibition augments coronary release of tissue plasminogen activator in women but not in men. Hypertension. 56(3): 364-368, 2010.

 Yoshino T, Nakae I, Matsumoto T, Mitsunami K, Horie M: Relationship between exercise

capacity and cardiac diastolic function assessed by time-volume curve from 16-frame gated myocardial perfusion SPECT. Ann Nucl Med. 24: 469-476, 2010.

 Oka Y, Itoh H, Ding WG, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Akashi

M, Kawamura M, Matsuura H, Horie M: Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to ongenital long QT syndrome. Circ J. 17: 2535-2571, 2010.

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 Nagaoka I, Shimizu W, Mizusawa Y, Sakaguchi T, Itoh H, Ohno S, Makiyama T, Yamagata

K, Makimoto H, Miyamoto Y, Kamakura S, Horie M: Heart rate-dependent variability of cardiac events in type 2 congenital long-QT syndrome. Europace. 12: 1623-1629, 2010.

 Hayashi H, Miyamoto A, Ishida K, Yoshino T, Sugimoto Y, Ito M, Horie M: Prevalence and

QT interval of early repolarization in a hospital-based population. J Arrhythm. 26: 127-133, 2010.

 Nakae I, Mitsunami K, Yoshino T, Omura T, Tsutamoto T, Matsumoto T, Morikawa S,

Inubushi T, Horie M: Clinical features of myocardial triglyceride in different types of cardiomyopathy assessed by proton magnetic resonance spectroscopy: Comparison with myocardial creatine. J Card Fail. 16: 812-822, 2010.

 Yamaji M, Tsutamoto T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie M: Effect

of eplerenone versus spironolactone on cortisol and hemoglobin a1(c) levels in patients with chronic heart failure. Am Heart J. 160: 915-921, 2010.

【2009】

 Ikrar T, Hanawa H, Watanabe H, Aizawa Y, Ramadan MM, Chinushi M, Horie M, Aizawa

Y: Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel. BBRC. 378(3): 589-594, 2009.

 Kawamura M, Ozawa T, Yao T, Ashihara T, Sugimoto Y, Yagi T, Itoh H, Ito M,

Makiyama T, Horie M: Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long-term follow-up. Circ J. 73: 584-588, 2009.

 Wu J, Ding WG, Matsuura H, Tsuji K, Zang WJ, Horie M: Inhibitory actions of the

phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel. Brit J Pharm. 156: 377-387, 2009.

 Zankov DP, Yoshida H, Tsuji K, Toyoda F, Ding WG, Matsuura H, Horie M: Adrenergic

regulation of the rapid component of delayed rectifier K+ current: Implications for arrhythmogenesis in LQT2 patients. Heart Rhythm. 6(7): 1038-1046, 2009.

 Itoh H, Sakaguchi T, Ashihara T, Ding G W, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H,

Ito M, Matsuura H, Horie M: A novel KCNH2 mutation as a modifier for short QT interval. Int J Cardiol. 137(1): 83-85, 2009.

 Nakazawa Y, Ashihara T, Tsutamoto T, Ito M, Horie M: Endothelin-1 as a predictor of atrial

fibrillation recurrence after pulmonary vein isolation. Heart Rhythm. 6(6): 725-730, 2009.

 Ohno S, Toyoda F, Zankov D, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K,

Matsuura H, Shimizu W, Miyamoto Y, Kamakura S, Kita T, Horie M: Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome. Hum Mutat. 30: 557-563, 2009.

 Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H,

Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H; J-RHYTHM Investigators: Optimal treatment strategy for patients with

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paroxysmal atrial fibrillation: J-RHYTHM Study. Circ J. 73: 242-248, 2009.

 Yamashita T, Ogawa S, Sato T, Aizawa Y, Atarashi H, Fujiki A, Inoue H, Ito M, Katoh T,

Kobayashi Y, Koretsune Y, Kumagai K, Niwano S, Okazaki O, Okumura K, Saku K, Tanabe T, Origasa H; J-BAF Investigators: Dose-response effects of bepridil in patients with persistent atrial fibrillation monitored with transtelephonic electrocardiograms: a multicenter, randomized, placebo-controlled, double-blind study (J-BAF Study). Circ J. 73: 1020-1027, 2009.

 Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura M, Horie M: Angiotensin II type 1

receptor mediates partially hyposmotic-induced increase of IKs current in guinea pig atrium. Pflugers Arch. 458: 837-849, 2009.

 Nishio Y, Makiyama T, Itoh H, Sakaguchi T, Ohno S, Gong Y-Z, Yamamoto S, Ozawa T,

Ding W-G, Toyoda F, Kawamura M, Akao M, Matsuura H, Kita T, Horie M: D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome. J Am Coll Cardiol. 54(9): 812-819, 2009.

 Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kanda H, Kita Y, Kadowaki T, Tsujita Y,

Turin T C, Horie M, Miki T, Ueshima H: Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study). Int J Cardiol. 136(3): 354-355, 2009.

 Inoue H, Fujiki A, Origasa H, Ogawa S, Okumura K, Kubota I, Aizawa Y, Yamashita T,

Atarashi H, Horie M, Ohe T, Doi Y, Shimizu A, Chishaki A, Saikawa T, Yano K, Kitabatake A, Mitamura H, Kodama I, Kamakura S: Prevalence of atrial fibrillation in the general population of Japan: An analysis based on periodic health examination. Int J Cardiol. 137: 102-107, 2009.

 Okamura T, Sekikawa A, Kadowaki T, El-Saed A, Abbott DR, Curb JD, Edmundowicz D,

Nakamura Y, Murata K, Kashiwagi A, Kim ST, Evans RW, Zmuda JM, Maegawa H, Hozawa A, Mitsunami K, Nisio Y, Iva MG, Horie M, Miyamastu N, Murakami Y, Kuller LH, Ueshima H: Cholesteryl ester transfer protein, coronary calcium and intima-media thickness of the carotid artery in middle-aged Japanese men. Am J Cardiol. 104(6): 818-822, 2009.

 Nishiyama K, Tsutamoto T, Tanaka T, Fujii M, Yamamoto T, Yamaji M, Horie M: Plasma

NT-proBNP as a more reliable biomarker of endogenous cardiac natriuretic peptides Than BNP during carperitide infusion. Int Heart J. 50(2): 183-190, 2009.

 Yamaji M, Tsutamoto T, Tanaka T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie

M: Effect of carvedilol on plasma adiponectin concentration in patients with chronic heart failure. Circ J. 73: 1067-1073, 2009.

 Kamakura S, Ohe T, Nakazawa K, Aizawa Y, Shimizu A, Horie M, Ogawa S, Okumura K,

Tsuchihashi K, Sugi K, Makita N, Hagiwara N, Inoue H, Atarashi H, Aihara N, Shimizu W, Kurita T, Suyama K, Noda T, Satomi K, Okamura H, Tomoike H: Long-term prognosis of probands with Brugada-pattern ST-Elevation in leads V1-V3. Circ Arrhythm Electrophysiol. 2(5): 495-503, 2009.

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Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M: Latent genetic backgrounds and molecular pathogenesis in drug-induced long QT syndrome. Circ Arrhythm Electrophysiol. 2(5): 511-523, 2009.

 Tsutamoto T, Kawahara C, Yamaji M, Nishiyama K, Fujii M, Yamamoto T, Horie M:

Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure. Eur J Heart Fail. 11(7): 653-658, 2009.

 Tsutamoto T, Tanaka T, Nishiyama K, Yamaji M, Kawahara C, Fujii M, Yamamoto T, Horie

M: Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension. Hypertens Res. 32(8): 670-674, 2009.

 Yamaji M, Tsutamoto T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie M:

Serum cortisol as a useful predictor of cardiac events in patients with chronic heart failure: The impact of oxidative stress. Circ Heart Fail. 2: 608-615, 2009.

 Nishiyama K, Tsutamoto T, Yamaji M, Kawahara C, Yamamoto T, Fujii M, Horie M: Dose-

Dependent prognostic effect of carvedilol in patients with chonic heart failure: Special reference to ranscardiac gragient of norepinephrine. Circ J. 73: 2270-2275, 2009.

 Yamaji M, Tsutamoto T, Tanaka T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie

M: Effect of carperitide on plasma adiponectin levels in acute decompensated heart failure patients with diabetes mellitus. Circ J. 73: 2264-2269, 2009.

 Tsutamoto T, Yamaji M, Kawahara C, Nishiyama K, Fujii M, Yamamoto T, Horie M: Effect

of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A1c levels in patients with non-ischaemic chronic heart failure. Eur J Heart Fail. 11(12): 1195-1201, 2009.

 Furukawa Y, Ehara N, Taniguchi R, Haruna Y, Ozasa N, Saito N, Doi T, Hoshino K,

Tamura T, Shizuta S, Abe M, Toma M, Morimoto T, Teramukai S, Fukushima M, Kita T, Kimura T; CREDO-Kyoto Investigators: Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization. Circ J. 2009: 73(8): 1459-1465.

【2008】

 Ashihara T, Constantino J, Trayanova NA: Tunnel propagation of postshock activations as

a unified hypothesis for fibrillation induction and isoelectric window. Circ Res. 102(6): 737-745, 2008.

 Harada M, Honjo H, Yamazaki M, Nakagawa H, Ishiguro Y, Okuno Y, Ashihara T, Sakuma

I, Kamiya K, Kodama I: Moderate hypothermia increases the chance of spiral wave collision in favor of self termination of ventricular tachycardia/fibrillation. Am J Physiol Heart Circ Physiol. 294(4): H1896-H1905, 2008.

 Ijiri T, Ashihara T, Yamaguchi T, Takayama K, Igarashi T, Namba T, Shimada T, Haraguchi

R, Nakazawa K: A procedural method for modeling the purkinje fibers of the heart. J Physiol Sci. 58(7): 481-486, 2008.

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interface for modeling myocardial fiber orientation that considers the layered structure of the ventricles. J Physiol Sci. 58(7): 487-492, 2008.

 Matsumoto T, Fujita M, Tarutani Y, Yamane T, Takashima H, Nakae I, Horie M:

Whole-body periodic acceleration enhances brachial endothelial function. Circ J. 72(1): 139-143, 2008.

 Ohno S, Kubota T, Yoshida H, Tsuji K, Makiyama T, Yamada S, Kuga K, Yamaguchi I,

Kita T, Horie M: A novel mutation associated with Jervell and Lange-Nielsen syndrome in a Japanese family. Circ J. 72(5): 687-693, 2008.

 Sakaguchi T, Shimizu W, Itoh H, Noda T, Miyamoto A, Nagaoka I, Oka Y, Ashihara T, Ito

M, Tsuji K, Ohno S, Makiyama T, Kamakura S, Horie M: Age- and genotype-specific triggers for life-threatening arrhythmia in the genotyped long-QT syndrome. J Cardiovasc Electrophysiol. 19(8): 794-799, 2008.

 Nagaoka I, Shimizu W, Itoh H, Yamamoto S, Sakaguchi T, Ashihara T, Ito M, Yoshida H,

Ohno S, Miyamoto Y, Kamakura S, Akao M, Horie M: Mutation site dependent variability of cardiac events in LQT2 form of congenital long-QT syndrom. Circ J. 72(5): 694-699, 2008.

 Makiyama T, Akao M, Shizuta S, Doi T, Nishiyama K, Oka Y, Ohno S, Nishio Y, Tsuji K,

Itoh H, Kimura T, Kita T, Horie M: A novel SCN5Again-of-function mutation M1875T associated with familial atrial fibrillation. J Am Coll Cardiol. 52(16): 1326-1334, 2008.

 Yasue H, Mizuno Y, Harada E, Itoh T, Nakagawa H, Nakayama M, Ogawa H, Tayama S,

Honda T, Hokimoto S, Ohshima S, Hokamura Y, Kugiyama K, Horie M, Yoshimura M, Harada M, Uemura S, Saito Y: Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition on coronary spasm after withdrawal of Ca-channel blockers. J Am Coll Cardiol. 51(18): 1742-1748, 2008.

 Tsutamoto T, Tanaka T, Sakai H, Nishiyama K, Fujii M, Yamamoto T, Nakae I, Ohnishi M,

Wada A, Horie M: Beneficial effect of perindopril on cardiac sympathetic nerve activity and brain natriuretic Peptide in patients with chronic heart failure. Circ J. 72(5): 740-746, 2008.

 Nakae I, Matsuo S, Matsumoto T, Mitsunami K, Horie M: Augmentation Index and Pulse

Wave Velocity as Indicators of Cardiovascular Stiffness. Angiology. 59: 421-426, 2008. .

 Matsuo S, Nakajima K, Horie M, Nakae I, Nishimura T; The J-ACCESS Investigators:

Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population. Circ J. 72(4): 611-617, 2008.

 Tanaka T, Tsutamoto T, Nishiyama K, Sakai H, Fujii M, Yamamoto T, Horie M: Impact of

oxidative stress on plasma adiponectin in patients with chronic heart failure. Circ J. 72(4): 563-568, 2008.

 Tanaka T, Tsutamoto T, Sakai H, Nishiyama K, Fujii M, Yamamoto T, Horie M: Effect of

atrial natriuretic peptide on adiponectin in patients with heart failure. Eur J Heart Fail. 10(4): 360-366, 2008.

 Tamaki S, Nakamura Y, Teramura M, Sakai M, 1, Takayama T, Okabayashi T, Kawashima

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home blood pressure record to the outpatient exam. Intern Med. 47(18): 1561-1565, 2008.

 Makiyama T, Akao M, Haruna Y, Tsuji K, Doi T, Ohno S, Nishio Y, Kita T, Horie M:

Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome. Circ J. 72: 1705-1706, 2008.

 Makita N, Behr E, Shimizu W, Horie M, Sunami A, Crotti L, Schulze-Bahr E, Fukuhara S,

Mochizuki N, Makiyama T, Itoh H, Christiansen M, McKeown P, Miyamoto K, Kamakura S, Tsutsui H, Schwartz P J, George Jr.A, Roden D: The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest. 118(6): 2219-2229, 2008.

 Yamada H, Yoshida M, Nakano Y, Suganami T, Satoh N, Mita T, Azuma K, Itoh M,

Yamamoto Y, Kamei Y, Horie M, Watada H, Ogawa Y: In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid. Arteroiscler Thromb Vasc Biol. 28: 2173-2179, 2008.

 Gong YZ, Ding WG, Wu J, Tsuji K, Horie M, Matsuura H: Cinnamyl-3,

4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. Eur J Pharmacol. 600(1-3): 18-25, 2008.

 Takayama T, Teramura M, Sakai H, Tamaki S, Okabayashi T, Kawashima T, Yamamoto T,

Horie M, Suzuki T, Asai T: Perforated mitral valve aneurysm associated with Libman-Sacks endocarditis. Intern Med. 47(18): 1605-1608, 2008.

 Nakae I, Matsuo S, Matsumoto T, Horie M: Clinical significance of diastolic function as an

indicator of myocardial ischemia assessed by 16-frame gated myocardial perfusion SPECT. Ann Nucl Med. 22: 677-683, 2008.

 Inoue T, Eguchi Y, Matsumoto T, Kijima Y, Kato Y, Ozaki Y, Waseda K, Oda H, Seiki K,

Node K, Urade Y: Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. Atherosclerosis. 201(2): 385-391, 2008.

 Sakaguchi T, Itoh H, Ding WG, Tsuji K, Nagaoka I, Oka Y, Ashihara T, Ito M, Yumoto Y,

Zenda N, Higashi Y, Takeyama Y, Matsuura H, Horie M: Hydroxyzine, a first generation H1-receptor antagonist, inhibits human ether-a-go-go related gene (HERG) current and causes syncope in a patient with the HERG mutation. J Pharmacol Sci. 108(4): 462-471, 2008.

 Tsutamoto T, Nishiyama K, Sakai H, Tanaka T, Fujii M, Yamamoto T, Yamaji M, Horie M:

Transcardiac increase in norepinephrine and prognosis in patients with chronic heart failure. Eur J Heart Fail. 10(12): 1208-1214, 2008.

 Horie M, Ishida K, Nishio Y, Nagaoka I, Matsui K: Genetic background of arrhythmogenic

right ventricular dysplasia/Cardiomyopathy: Time to start asian registry. J Arrhythm. 24: 195-199, 2008.

 Matsuo S, Nakajima K, Kinuya S, Sato Y, Matsumoto N, Horie M: Cardiac scintigraphic

findings of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: A case report. Exp Clin Cardiol. 13: 93-95, 2008.

 Furukawa Y, Taniguchi R, Ehara N, Ozasa N, Haruna Y, Saito N, Doi T, Hoshino K,

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CREDO-Kyoto Investigators: Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease: perspectives from the CREDO-Kyoto registry. Circ J. 73: 1937-1945, 2009.

【2007】

 Ohno S, Zankov D, Yoshida H, Tsuji K, Makiyama T, Itoh H, Akao M, Hancox JC, Kita T,

Horie M: N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome. Heart Rhythm. 4(3): 332-340, 2007.

 Tsuji K, Akao M, Ishii T, Ohno S, Makiyama T, Doi T, Haruna Y, Yoshida H, Nakashima T,

Kita T, Horie M: Mechanistic basis for the pathogenesis of long QT syndrome caused by a splicing mutation in KCNQ1 gene. J Mol Cell Cardiol. 42(3): 662-669, 2007.

 Tsujita Y, Nakamura Y, Zhang Q, Tamaki S, Nozaki A, Amamoto K, Kadowaki T, Kita Y,

Okamura T, Horie M, Ueshima H: The association between high-density lipoprotein cholesterol level and cholestery1 ester transfer protein taqIB gene polymorphism is influenced by alcohol drinking in a population-based sample. Atherosclerosis. 191(1): 199-205, 2007.

 Nagatani Y, Takahashi M, Takazakura R, Nitta N, Murata K, Ushio N, Matsuo S,

Yamamoto T, Horie M: Multidetector-row computed tomography coronary angiography: optimization of image reconstruction phase according to the heart rate. Circ J. 71(1): 112-121, 2007.

 Toda H, Ding WG, Yasuda Y.Toyoda F, Ito M, Matsuura H, Horie M: Stimulatory action of

protein kinase Cvarepsilon isoform on the slow component of delayed rectifier K(+) current in guinea-pig atrial myocytes. Br J Pharmacol. 150: 1011-1021, 2007.

 Sakai H, Tsutamoto T, Ishikawa C, Tanaka T, Fujii M, Yamamoto T, Takashima H, Horie

M: Direct comparison of brain natriuretic peptide (BNP) and N-terminal pro-BNP secretion and extent of coronary artery stenosis in patients with stable coronary artery disease. Circ J. 71(4): 499-505, 2007.

 Matsuo S, Nakae I, Tsutamoto T, Okamoto N, Horie M: A novel clinical indicator using

Tc-99m sestamibi for evaluating cardiac mitochondrial function in patients with cardiomyopathies. J Nucl Cardiol. 14(2): 215-220, 2007.

 Itoh H, Tsuji K, Sakaguchi T, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ashihara T, Ito

M, Horie M, Imoto K: A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome. Int J Cardiol. 121(3): 249-252, 2007.

 Takashima H, Matsumoto T, Nakae I, Yamane T, Horie M: Cigarette smoking impairs

bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Thrombo Res. 120: 791-796. 2007.

 Todo T, Haraguchi R, Namba T, Yao T, Ashihara T, Higashi M, Inada H, Nakazawa K:

Development of “Cardiac Arrhythmia Risk Evaluation” system based on computer simulation. Proc IEEE/ICME Int Conf Complex Med Eng. 182-185, 2007.

 Haraguchi R, Igarashi T, Owada S, Yao T, Namba T, Ashihara T, Ikeda T, Nakazawa K:

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Medical Engineering: Springer-Verlag, 107-116, 2007.

 Tsutamoto T, Tanaka T, Sakai H, Ishikawa C, Fujii M, Yamamoto T, Horie M: Total and

high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure. Eur Heart J. 28: 1723-1730. 2007.

 Nakae I, Mitsunami K, Matsuo S, Horie M: Creatine Depletion and Altered Fatty Acid

Metabolism in Diseased Human Hearts: Clinical Investigation Using (1)H Magnetic Resonance Spectroscopy and (123)I BMIPP Myocardial Scintigraphy. Acta Radiol. 48(4): 436-443, 2007.

 Tsutamoto T, Sakai H, Ishikawa C, Fujii M, Tanaka T, Yamamoto T, Takashima H, Ohnishi

M, Wada A, Horie M: Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N-terminal pro-BNP in patients with chronic heart failure. Eur J Heart Fail. 9(6-7): 667-673, 2007.

 Tsutamoto T, Sakai H, Tanaka T, Fujii M, Yamamoto T, Wada A, Ohnishi M, Horie M:

Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure. Circ J. 71: 915-921, 2007.

 Horie M, Ito H: Disorders of cardiac repolarization: Long QT and short QT syndromes.

Circ J. 71: A50-A53. 2007.

 Lu J, Zhu SM, Zang WJ, Xu XL, Luo HL, Yu XJ, Wang SP, Kong SS, Wu J, Horie M, Sun

L: Protective mechanism of adenosine to the rat arterial endothelial dysfunction induced by hydrogen peroxide. Biol Pharm Bull. 30(7): 1206-1211, 2007.

 Tanaka T, Tsutamoto T, Sakai H, Fujii M, Yamamoto T, Horie M: Effect of efonidipine

versus amlodipine on aldosterone in patients with hypertension. Hypertens Res. 30(8): 691-697, 2007.

 Tsutamoto T, Asai S, Tanaka T, Sakai H, Nishiyama K, Fujii M, Yamamoto T, Ohnishi M,

Wada A, Saito Y, Horie M: Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure. Eur J Heart Fail. 9(10): 1032-1037, 2007.

 Tanaka T, Tsutamoto T, Sakai H, Fujii M, Yamamoto T, Horie M: Comparison of the effects

of efonidipine and amlodipine on aldosterone in patients with hypertension. Hypertens Res. 30(8): 691-697, 2007.

 Crotti L, Spazzolini C, Schwartz P, Shimizu W, Denjoy I, Schulze-Bahr E,

Zaklyazminskaya E, Swan H, Ackerman M, Moss A, Wilde A, Horie M, Brink P, Insolia R, Ferrari G, Crimi G: The common long QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: Toward a mutation-specific risk stratification. Circulation. 116: 2366-2375, 2007.

 Tsutamoto T, Sakai H, Nishiyama K, Tanaka T, Fujii M, Yamamoto T, Horie M: Direct

comparison of transcardiac increase in brain natriuretic peptide (BNP) and N-terminal proBNP and prognosis in patients with chronic heart failure. Circ J. 71(12): 1873-1878, 2007.

 Sumitomo N, Sakurada H, Taniguchi K, Matsumura M, Abe O, Miyashita M, Kanamaru H,

Karasawa K, Ayusawa M, Fakamizu S, Nagaoka I, Horie M, Harada K, Hiraoka M: Association of atrial arrhythmia and sinus node dysfunction in patients with

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catecholaminergic polymorphic ventricular tachycardia. Circ J. 71(10): 1606-1609, 2007.

 Sugimoto T, Hajiro T, Fujimoto T, Kojyo N, Horie M, Kashiwagi A: Thrombotic

microangiopathy in an adult patient with clinically amyopathic dermatomyositis complicated with interstitial lung disease. Lupus. 16(12): 1004-1005. 2007.

 Hayashi H, Shiferaw Y, Sato D, Nihei M, Lin S, Chen P, Garfinkel A, Weiss N J, Qu Z:

Dynamic origin of spatially discordant alternans in cardiac tissue. Biophys J. 92: 448-460, 2007.

 Namba T, Haraguchi R, Igarashi T, Owada S, Yao T, Ashihara T, Todo T, Ikeda T,

Nakazawa K: Development of graphical interface for modeling excitation map in the electrophysiological heart simulator. Proc IEEE/ICME Int Conf Complex Med Eng. 168-171, 2007.

 Namba T, Todo T, Yao T, Ashihara T, Haraguchi R, Nakazawa K, Ikeda T, Ohe T:

Identification of local myocardial repolarization time by bipolar electrode potential. J Electrocardiol. 40(Suppl.6): S97-S102, 2007.

 Takagi M, Yokoyama Y, Aonuma K, Aihara N, Hiraoka M; for the Japan Idiopathic

ventricular fibrillation study (J-IVFS) investigators: Clinical characteristics and risk stratification in symptomatic and asymptomatic patients with Brugada syndrome. J Cardiovasc Electrophysiol. 18(12): 1244-1251, 2007.

 Nakae I, Matsuo S, Tsutamoto T, Matsumoto T, Mitsunami K, Horie M: Assessment of

cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT. Ann Nucl Med. 21: 315-323, 2007.

【2006】

 Dohke, Wada A, Isono T, Fujii M, Yamamoto T, Tsutamoto T, Horie M: Proteomic analysis

reveals significant alternations of cardiac small heat shock protein expression in congestive heart failure. J Cardiac Fail. 12(1): 77-84, 2006.

 Hatada K, Washizuka T, Horie M, Watanabe H, Yamashita F, Chinushi M, Aizawa Y:

Tumor necrosis factor-alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway. Biochem Biophys Res Commun. 344: 189-193, 2006.

 Ishikawa C, Tsutamoto T, Fujii M, Sakai H, Tanaka T, Horie M: Prediction of mortality by

high-sensitivity C-reactive protein and brain natriuretic Peptide in patients with dilated cardiomyopathy. Circ J. 70: 857-863, 2006.

 Lu J, Nishi T, Ashihara T, Schnider N, Amano A, Matsuda T, Kotera H: The influence of

activation time on the contraction force of myocardial tissue: A simulation study. Conf Proc IEEE Eng Med Biol Soc. 1: 2900-2903, 2006.

 Itoh H, Horie M, Ito M, Imoto K: Arrhythmogenesis in the short-QT syndrome associated

with combined HERG channel gating defects: A simulation study. Circ J. 70(4): 502-508, 2006.

 Matsuo S, Nakae I, Matsumoto T, Horie M: Impact of endothelial dysfunction on left

ventricular remodeling after successful primary coronary angioplasty for acute myocardial infarction: Analysis by quantitative ECG-gated SPECT. Ann Nucl Med. 20: 57-62, 2006.

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 Matsuo S, Sato Y, Nakae I, Masuda D, Matsumoto N, Horie M: Evaluation of cardiac

resynchronization therapy in drug-resistant dilated-phase hypertrophic cardiomyopathy by means of Tc-99m sestamibi ECG-gated SPECT. Ann Nucl Med. 20(9): 643-647, 2006.

 Nakae I, Matsuo S, Koh T, Mitsunami K, Horie M: Iodine-123 BMIPP scintigraphy in the

evaluation of patients with heart failure. Acta Radiol. 47: 810-816, 2006.

 Ozawa T, Ito M, Tamaki S, Yao T, Ashihara T, Kita Y, Okamura T, Ueshima H, Horie M:

Gender and age effects on ventricular repolarization abnormality in Japanese general carriers of G643S common single nucleotide polymorphism of KCNQ1 gene. Circ J. 70(6): 645-650, 2006.

 Sakai H, Tsutamoto T, Tsutsui T, Tanaka T, Ishikawa C, Horie M: Serum Level of Uric

Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure. Circ J. 70: 1006-1011, 2006.

 Schwartz PJ, Spazzolini C, Crotti L, Bathen J, Denjoy I, Schulze-Bahr E, Amlie JP,

Timothy K, Shkolnikova M, Berul C, Bitner-Glindzicz M, Toivonen L, Horie M: The Jervell and Lange-Nielsen Syndrome. Molecular basis, natural history, and clinical outcome. Circulation. 113: 783-790, 2006.

 Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kita Y, Kadowaki T, Tsujita Y, Horie M,

Miki T, Ueshima H: Relationship between metabolic syndrome and Trp64Arg polymorphism of the β3-Adrenergic receptor gene in a general sample: the Shigaraki study. Hypertens Res. 29(11): 891-896, 2006.

 Tamaki S, Nakamura Y, Yoshino T, Matsumoto Y, Tarutani Y, Okabayashi T, Kawashima T,

Horie M: The association between morning hypertension and metabolic syndrome in hypertensive patients. Hypertens Res. 29: 783-788, 2006.

 Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA: Nuclear

Targeting of Akt Antagonizes Aspects of Cardiomyocyte Hypertrophy. Proc Natl Acad Sci U S A. 103(32): 11946-11951, 2006.

 Tsutamoto T, Wada A, Sakai H, Ishikawa C, Tanaka T, Hayashi M, Fujii M, Yamamoto T,

Dohke T, Ohnishi M, Takashima H, Kinoshita M, Horie M: Relationship between renal function and plasma brain natriuretic Peptide in patients with heart failure. J Am Coll Cardiol. 47: 582-586, 2006.

 Yamane T, Matsumoto T, Nakae I, Takashima H, Tarutani Y, Tamaki S, Horie M: Impact of

paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation. Hypertens Res. 29(6): 417-422, 2006.

 Zhang CT, Yasuno S, Kuwahara K, Zankov D, Kobori A, Makiyama T, Horie M: Blockade

of Angiotensin II type 1 receptor improves the arrhythmia morbidity in mice with left ventricular hypertrophy. Circ J. 70(3): 335-341, 2006.

 Zankov DP, Toyoda F, Ding WG, Matsuura H, Horie M: Angiotensin II potentiates IKs

potassium current via AT1 receptors in guinea-pig atrial myocytes. Circulation. 113(10): 1278-1286, 2006.

 Zankov DP, Omatsu-Kanbe M, Toyoda F, Ding WG, Matsuura H, Isono T, Horie M:

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delayed rectifier K+ Current via the AT1 receptor in guinea pig atrial myocytes". Circulation. 114: e556, 2006.

【2005】

 Aiba T, Shizimu W, Inagaki M, Noda T, Miyoshi S, Ding W-G, Zankov DP, Toyoda F,

Matuura H, Horie M, Sunagawa K: Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil. J Am Coll Cardiol. 45: 300-307, 2005.

Ashihara T, Trayanova NA: Cell and tissue responses to electric shocks. Europace. 7:

155-165, 2005.

 Hamamoto T, Tanaka H, Mani H, Tanabe T, Fujiwara K, Nakagami T, Horie M, Oyamada

M, Takamatsu T: In situ Ca2+ dynamics of Purkiinje fibers and its interconnection with subjacent ventricular myocytes. J Mol Cell Cardiol. 38: 561-569, 2005.

 Haraguchi R, Igarashi T, Owada S, Yao T, Namba T, Ashihara T, Ikeda T, Nakazawa K:

Electrophysiological heart simulator equipped with sketchy 3-D modeling. Proc IEEE/ICME Int Conf Complex Med Eng. 293-296, 2005.

 Isikawa C, Tsutamoto T, Wada A, Fujii M, Ohno K, Sakai H, Yamamoto T, Horie M:

Inhibition of aldosterone and endothelin-1 by carperitide was attenuated more than one week Infusion in patients with congestive heart failure. J Cardiovasc Pharmacol. 46: 513-518, 2005.

 Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M,

Sussman MA: Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest. 115: 2716-2730, 2005.

 Makiyama T, Akao M, Tsuji K, Doi T, Ohno S, Takenaka K, Kobori A, Ninomiya T,

Yoshida H, Takano T, Makita N, Yanagisawa F, Higashi Y, Takeyama Y, Kita T, Horie M: High-risk for bradyarrhythmic complications in patients with Brugada syndrome caused by SCN5A gene mutations. J Am Coll Cardiol. 46: 2100-2106, 2005.

 Matsuo S, Nakamura I, Yamada T, Uchida I, Nakae I, Horie M: Effect of statin therapy on

arterial stiffness in patients with hyperlipidemia: Shiga pravastatin atherosclerosis study (SHIPAS) group. J Appl Res. 5: 397-401, 2005.

 Nakae I, Mitsunami K, Matsuo S, Inubushi T, Morikawa S, Tsutamoto T, Koh T, Horie M:

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