ࣀ㓟㓄ิࡢ┦ྠᛶࡢ᳨ウ
BRVB ࡢ VP3㸪NSP3࠾ࡼࡧ NSP4 ࡢ㛗CDS ࡢሷᇶ࠾ࡼࡧ࣑ࣀ㓟㓄
ิࢆࡢRVBᰴẚ㍑ࡋࡓࠋBRVBࢆࡢRVBẚ㍑ࡋࡓࡁ㸪VP3㸪NSP3
࠾ࡼࡧ NSP4 㡿ᇦࡢ┦ྠᛶࡣሷᇶ㓄ิ࡛ 63.3–64.9%㸪65.9–68.2%࠾ࡼࡧ 52.6–56.2%㸪࣑ࣀ㓟㓄ิ࡛60.9–63.0%㸪56.4–60.3%࠾ࡼࡧ36.1–39.3%࡛࠶
47
ࡗࡓ㸦⾲ 3-2㹼3-4㸧ࠋVP3㸪NSP3 ࠾ࡼࡧ NSP4 㡿ᇦࡢࣛࢵࢺ㸪ࣄࢺ࠾ࡼࡧ㇜
RVBࡢ㑇ఏᏊᆺࢆM1-T1-E1㸪M2-T2-M2࠾ࡼࡧM4-T4-E4ࡋ㸪BRVBࡢ㑇
ఏᏊᆺࢆ M3-T3-E3 ௬ྡࡋࡓࠋᆺู᭱ࡶ㐺ᙜ࡞࢝ࢵࢺ࢜ࣇ್ࢆ㸪┦ྠ
ᛶศᕸᅗ࠾࠸࡚㑇ఏᏊᆺእ┦ྠᛶࡢฟ⌧㢖ᗘࢆ㑇ఏᏊෆ┦ྠᛶࡢฟ⌧㢖ᗘ࡛
㝖ࡋࡓ್ࡀ㸯ࢆୗᅇࡿ⨨࠾ࡅࡿ┦ྠᛶࡢ್ࡋࡓࠋࡇࢀᚑࡗ࡚ィ⟬ࡍࡿ
㸪ሷᇶ㓄ิ࠾ࡼࡧ࣑ࣀ㓟ࡢ࢝ࢵࢺ࢜ࣇ್ࡣ㸪VP3࡛ࡑࢀࡒࢀ70%࠾ࡼࡧ73%㸪 NSP3࡛78%࠾ࡼࡧ74%㸪NSP4࡛70%࠾ࡼࡧ69%࡛࠶ࡗࡓ㸦ᅗ3-5㹼3-7㸧ࠋ
4. 㑇ఏᏊࢭࢢ࣓ࣥࢺ࠾ࡅࡿศᏊ⣔⤫ᶞゎᯒ
㛗ࡢ VP3㸪NSP3࠾ࡼࡧ NSP4ࡢ࣑ࣀ㓟㓄ิࡼࡿ⣔⤫ᶞゎᯒ࡛ࡣ㸪 BRVBࡣM3㸪T3࠾ࡼࡧE3௬ྡࡋࡓࢢ࣮ࣝࣉࢆᙧᡂࡋ㸪ࣄࢺ㸦M2-T2-E2㸧㸪
㇜㸦M4-T4-E4㸧࠾ࡼࡧࣛࢵࢺ㸦M1-T1-E1㸧ࡢ RVB ࡣ㞳ࢀ࡚ࢡࣛࢫࢱ࣮ࢆ
ᙧᡂࡋࡓ㸦ᅗ3-8 a, b, c㸧ࠋ
ḟ㒊ศⓗ࡞VP7㸪VP4㸪VP6㸪VP1㸪VP2㸪NSP1㸪NSP2࠾ࡼࡧNSP5
࣑ࣀ㓟㓄ิࢆ⏝࠸࡚⣔⤫ᶞゎᯒࢆ⾜ࡗࡓࠋVP7 ࡼࡿ⣔⤫ᶞゎᯒ࡛ࡣ㸪ᡃࡀᅜ ࡢBRVBᰴࡣ⡿ᅜࡢBRVB࣑ࣀ㓟㓄ิ࡛95.8㸫99.2%ࡢ┦ྠᛶࢆ♧ࡋ㸪
ࡶG3㑇ఏᏊᆺศ㢮ࡉࢀࡓࠋࣥࢻࡢBRVBࡣ㸪ᡃࡀᅜࡢBRVB࣑ࣀ
㓟㓄ิ࡛85.0㹼88.8㸣ࡢ┦ྠᛶࢆ♧ࡋࡓࡀ㸪ᡃࡀᅜࡢBRVBࡣᑡࡋ␗࡞ࡗࡓ ศᒱࢆ♧ࡋ㸪G5㑇ఏᏊᆺࢆᙧᡂࡋࡓ㸦ᅗ3-9 A㸪⾲3-5㸧ࠋNSP2ࡘ࠸࡚ࡣ㸪 ᡃࡀᅜࡢBRVBࡣࣥࢻࡢBRVBࡣ࣑ࣀ㓟࡛ࣞ࣋ࣝ89.1-92.0㸣㸪㇜RVB
ࡣ 86.2-89.1㸣ࡢ┦ྠᛶࢆ♧ࡋ㸪ࣥࢻࡢ BRVB࠾ࡼࡧ㇜ RVB ࡶN2
㑇ఏᏊᆺศ㢮ࡉࢀࡓ㸦ᅗ3-9 G㸪⾲3-11㸧ࠋNSP5࡛ࡣ㸪ᡃࡀᅜࡢBRVBࡣ
ࣥࢻࡢBRVB࣑ࣀ㓟㓄ิ࡛85.6-88.6㸣ࡢ┦ྠᛶࢆ♧ࡋ㸪ࡶH6㑇ఏᏊ ᆺศ㢮ࡉࢀࡓ㸦ᅗ3-9 H㸪⾲3-12㸧ࠋVP6࡛ࡣ㸪ᡃࡀᅜࡢBRVBࡣࣥࢻࡢ
48
BRVB ࡣ 92.1-95.2㸣ࡢ┦ྠᛶࢆ♧ࡋ㸪ഹศᒱࡀ␗࡞ࡿࡀ㸪ࡶ I3 ࢡ
ࣛࢫࢱ࣮ࢆᙧᡂࡋࡓ㸦ᅗ3-9 C㸪⾲3-7㸧ࠋNSP1࣌ࣉࢳࢻ2ࡘ࠸࡚ࡣ㸪ᡃࡀᅜ ࡢBRVBࡣ⊂❧ࡋࡓࢡࣛࢫࢱ࣮ࢆᙧᡂࡋࡓࡀ㸪ࣄࢶࢪࡢRVB67.9–68.8%ࡢ
࣑ࣀ㓟┦ྠᛶࢆ♧ࡋ㸪ࡶ I3 㑇ఏᏊᆺࢆᙧᡂࡋࡓ㸦ᅗ 3-9 F㸪⾲ 3-10㸧ࠋ NSP1࣌ࣉࢳࢻ1ࡘ࠸࡚ࡣG-2006ࡢࡳࡢ㓄ิࡋᚓࡽࢀࡎ㸪ࡇࡢ㓄ิࡣࣄࢶ
ࢪ RVB ࡢࡑࢀ 75.2%ࡢ࣑ࣀ㓟㓄ิ┦ྠᛶࢆ♧ࡋࡓ㸦ࢹ࣮ࢱᮍᥖ㍕㸧ࠋ㑇ఏ
Ꮚᆺࡀᥦၐࡉࢀ࡚࠸࡞࠸ VP4㸪VP1 ࠾ࡼࡧ VP2 ࡘ࠸࡚ࡣ㸪ᡃࡀᅜࡢ BRVB ࡣࣥࢻࡢ BRVB ࣑ࣀ㓟࡛ࣞ࣋ࣝࡑࢀࡒࢀ 90.0–91.7%㸪85.4–87.6%࠾ࡼ
ࡧ94.9–97.1%ࡢ┦ྠᛶࢆ♧ࡋ㸪ྠࡌࢡࣛࢫࢱ࣮ᒓࡋࡓ㸦ᅗ3-9 B, D, E㸪⾲
3-6, 3-8, 3-9㸧ࠋ
49
⪃ ᐹ
ᮏ❶࠾ࡅࡿゎᯒ࡛ࡣ࣓ࢱࢤࣀ࣒ࡢᡭἲࢆ⏝࠸ࡓࢩ࣮ࢡ࢚ࣥࢫἲࡼࡾ㸪⣅
౽ࡽ┤᥋ᢳฟࡋࡓ RNA ࢆࡗ࡚ BRVB ࢤࣀ࣒㓄ิࢆỴᐃࡋࡓࠋ⣅౽୰ࡣ ᐟ⏤᮶ࡸ⣽⳦࡞ࡢ㑇ఏᏊࡀከࡃྵࡲࢀ࡚࠸ࡿࡇࡽ㸪ࡑࢀࡽ⏤᮶ࡍࡿ1 ᮏ㙐RNAࢆ㝖ཤࡍࡿࡓࡵS1ࢾࢡ࣮ࣞࢮࢆ⏝ࡋࡓࠋS1ࢾࢡ࣮ࣞࢮࡣ࣓ࢱ ࢤࣀ࣒ࡼࡿࢹ࣮ࣉࢩ࣮ࢡ࢚ࣥࢫࢆ┠ⓗࡋࡓゎᯒ⏝ࡢࣛࣈ࣮ࣛࣜࢆస〇 ࡍࡿ㝿᭷ຠ࡛࠶ࡿࡇࡀド᫂ࡉࢀ࡚࠸ࡿ㸦78㸧ࠋࡇࡢᡭἲࢆᛂ⏝ࡍࡿࡇ࡛
VP3㸪VP7ࠊNSP1㸪NSP3㸪NSP4 ࠾ࡼࡧ NSP5 ࡢ㛗ࡢ CDS 㓄ิࢆᚓࡿ
ࡇࡀ࡛ࡁࡓࠋ୍᪉㸪VP4㸪VP6㸪VP1㸪VP2 ࠾ࡼࡧ NSP2 ࡣ㒊ศⓗ࡞㓄ิࡋ
ᚓࡿࡇࡀ࡛ࡁ࡞ࡗࡓࠋࡇࢀࡣ࢘ࣝࢫ㑇ఏᏊࡢ㔞ࡀ༑ศ࡛࡞ࡗࡓࡇ
ࡸࢩ࣮ࢡ࢚ࣥࢫࡋࡃ࠸㓄ิࢆ᭷ࡋ࡚࠸ࡿࡇ㉳ᅉࡋ࡚࠸ࡿ⪃࠼ࡽࢀࡓࠋ ࡋࡋࡇࢀࡽࡢࢭࢢ࣓ࣥࢺࡶ⣔⤫ᶞゎᯒ౪ࡍࡿ༑ศ࡞㑇ఏᏊ㛗ࡀᚓࡽࢀ㸪 11 ࢭࢢ࣓ࣥࢺ࡚ࡘ࠸࡚ศᏊ⣔⤫ᶞゎᯒࢆ⾜࠺ࡇࡀྍ⬟࡛࠶ࡗࡓࠋBRVB ࡢVP3㸪NSP3࠾ࡼࡧNSP4㑇ఏᏊࡢሗࡣDDBJ/EMBL/GenBankࢹ࣮ࢱ࣋
࣮ࢫⓏ㘓ࡀ࡞ࡗࡓࡇࡽ㸪ᮏ❶ࡢ◊✲࡛᫂ࡽࡉࢀࡓࡇࢀࡽࡢ㓄ิࡣ ୡ⏺ึࡢሗ࿌࡛࠶ࡿࠋ
ࣟࢱ࢘ࣝࢫࡢ VP3 ࡣ N7-MTase ࡸ GTase/RTPase ࡞ከᶵ⬟ᛶࡢ࢟ࣕࢵ
ࣆࣥࢢ㓝⣲ᶵ⬟ࢆ᭷ࡍࡿ㸦65㸧ࠋBRVBࡢVP3ࡢ࣑ࣀ㓟㓄ิࡣ60.9–63.0%㸪
ࡢRVBࡣప࠸┦ྠᛶࢆ♧ࡋࡓࡀ㸪N7-MTaseࡸGTase/RTPaseࢻ࣓ࣥࢆ
☜ㄆࡍࡿࡇࡀ࡛ࡁࡓࠋࡍ࡞ࢃࡕࠊᅇゎᯒࡋࡓBRVBᰴࡢVP3ࡶࠊ࢘ࣝࢫ mRNA ྜᡂࡢ࢟ࣕࢵࣆࣥࢢᛂ㔜せ࡞ᶵ⬟ࢆ᭷ࡍࡿࡇࡀᙉࡃ♧၀ࡉࢀࡓࠋ
ࣟࢱ࢘ࣝࢫࡢNSP3ࡢNᮎ➃㡿ᇦࡣࣟࢱ࢘ࣝࢫmRNAࡢ3’UTRᏑᅾ ࡍࡿ≉ᐃࡢሷᇶ㓄ิ⤖ྜࡍࡿ୍᪉㸪ࡑࡢ C ᮎ➃㡿ᇦࡣ⩻ヂ㛤ጞᅉᏊࡋ࡚▱
50
ࡽࢀࡿeIF4G⤖ྜࡍࡿ㸦16㸧ࠋNSP3ࡢࡇࢀࡽࡢ⤖ྜάᛶࡣ࢘ࣝࢫmRNA
ࡢ⩻ヂᙳ㡪ࡍࡿ㸦96㸧ࠋBRVBࡢNSP3࠾ࡅࡿRNA⤖ྜ㡿ᇦࡣಖᏑࡉࢀ࡚
࠸ࡓࡀ㸪eIF4G ⤖ྜ㡿ᇦࡣࡢRVBࡸRVAࡢྠ㡿ᇦࡣ࡞ࡾ␗࡞ࡗ࡚࠸ࡓ (16)ࠋBLASTゎᯒ࡛ࡣBRVBࡢNSP3᭱ࡶ┦ྠᛶࡀ㧗ࡗࡓࡢࡣ㇜RVBࡢ RVB/Pig-wt/VNM/14250/2012/GXP[X] ᰴ࡛࠶ࡗࡓ(70)ࠋࡋࡋࡇࡢᰴࡢ㓄ิ
㸦ࢡࢭࢵࢩࣙࣥ␒ྕ KX362419㸧ࡣ 242 ሷᇶᑐ▷ࡍࡂࡿࡓࡵ㸪⣔⤫ᶞゎᯒ
ຍ࠼ࡿࡇࡣ࡛ࡁ࡞ࡗࡓ㸦ࢹ࣮ࢱᮍᥖ㍕㸧ࠋ
RVAࡢNSP4ࡣ᭱ึ㸪⭠⟶ࡢ⣽⬊ෆࡢ࢝ࣝࢩ࣒࢘ࣞ࣋ࣝࢆኚࡉࡏࡿࡇ
ࡼࡾஙࡢࡳ࣐࢘ࢫᖺ㱋౫Ꮡᛶࡢୗ⑩ࢆᘬࡁ㉳ࡇࡍ࢘ࣝࢫᛶ࢚ࣥࢸࣟࢺ࢟
ࢩࣥࡋ࡚ሗ࿌ࡉࢀࡓ㸦7,18,38㸧ࠋBRVB ࡢ NSP4 ࣑ࣀ㓟㓄ิࡣࣄࢺ㸪㇜࠾
ࡼࡧࣛࢵࢺ RVB ࡢࡑࢀࡣ┦ྠᛶࡀ 36.1–39.3%ⴭࡋࡃపࡗࡓࠋRVA ࡢ NSP4 ࣑ࣀ 㓟 㓄ิ 113–135 ┦ᙜࡍࡿ࢚ࣥࢸࣟࢺ࢟ࢩࣥࢻ࣓ࣥࡣ caveolin-1⤖ྜࡍࡿ㸦6㸧ࠋࣄࢺRVB CAL-1ᰴࡢNSP࣑ࣀ㓟㓄ิ106–127
ࡢ࢚ࣥࢸࣟࢺ࢟ࢩࣥᵝࢻ࣓ࣥࡣ㸪RVAࡢ࢚ࣥࢸࣟࢺ࢟ࢩࣥࢻ࣓ࣥ27%
ࡢ┦ྠᛶ࡛࠶ࡿ㸦41㸧ࠋࡋࡋ࡞ࡀࡽᅇゎᯒࡋࡓ BRVB ࡢ NSP4 ࡣ࢚ࣥࢸ
ࣟࢺ࢟ࢩࣥᵝࢻ࣓ࣥ┦ᙜࡍࡿ࣑ࣀ㓟㓄ิࡣぢࡘࡽ࡞ࡗࡓࠋࡼࡗ࡚㸪
ᅇ᳨ฟࡉࢀࡓBRVBࡣNSP4ࡢ࢚ࣥࢸࣟࢺ࢟ࢩࣥάᛶ౫Ꮡࡍࡿࡇ࡞ࡃୗ
⑩ࢆⓎࡉࡏࡿ⬟ຊࢆ᭷ࡍࡿࡇࡀ♧၀ࡉࢀࡓࠋRVAࡢNSP4ࡢNᮎ➃㡿ᇦ
࠶ࡿ⣙20࣑ࣀ㓟ࡽᵓᡂࡉࢀࡿ3࢝ᡤࡢỈᛶࢻ࣓ࣥh1-h3ࡢh2ࡣ㸪࢘
ࣝࢫࡢᙧែᙧᡂࡍࡿ㝿⭷㏱㐣ᛶࢆㄪᩚࡍࡿᙺࢆᢸࡗ࡚࠸ࡿ㸦41㸧ࠋSOSUI
ࣉࣟࢢ࣒ࣛࡼࡾ㸪ᅇゎᯒࡋࡓ IS-1 ࠾ࡼࡧ᪤▱ࡢࣄࢺ RVB ࡢ ADRV ᰴ
NSP4 ࡢ⭷㈏㏻㡿ᇦࡀᏑᅾࡍࡿࡇࡀド᫂ࡉࢀࡓࠋࡲࡓ㸪∵ RVA ࡢ NCDV ᰴ
࠾࠸࡚ࡶ MTHMM ࣉࣟࢢ࣒ࣛࡼࡾ NSP4 ⭷㈏㏻㡿ᇦࡀ♧ࡉࢀࡓࠋࡍ࡞
ࢃࡕ㸪SOSUIMTHMMࣉࣟࢢ࣒ࣛࡢ㛫୍࡛⮴ࡋࡓ⤖ᯝࡣᚓࡽࢀ࡞
51
ࡗࡓࡶࡢࡢ㸪㢮ఝࡋࡓỈࣉࣟࣇࣝࣃࢱ࣮ࣥࡀBRVB㸪ࣄࢺRVB࠾ࡼࡧ∵
RVA☜ㄆࡉࢀࡓࠋ
⌧ᅾ㸪RVBࡣ21✀ࡢVP7 G㑇ఏᏊᆺ㸦51㸧㸪13✀ࡢVP6 I㑇ఏᏊᆺ㸦54㸧㸪 7✀ࡢNSP1 A㑇ఏᏊᆺ㸦82㸧㸪4✀ࡢNSP2 N㑇ఏᏊᆺ㸦84㸧࠾ࡼࡧ6✀ࡢ NSP5 H㑇ఏᏊᆺࡀሗ࿌ࡉࢀ࡚࠸ࡿ(83,84)ࠋࡲࡓNSP1ࡣ࣌ࣉࢳࢻ1࠾ࡼࡧ࣌
ࣉࢳࢻ2ศࢀ࡚࠾ࡾ㸪ࡑࢀࡒࢀ7ࡘࡢA㑇ఏᏊᆺศ㢮ࡉࢀ࡚࠸ࡿ㸦82㸧ࠋ ᮏ❶࡛ࡢ⣔⤫ᶞゎᯒࡢ⤖ᯝ㸪ᡃࡀᅜࡢBRVBࡣG3㸪I3㸪N2࠾ࡼࡧH6㑇ఏᏊ ᆺࢆ♧ࡍࡇࡀࢃࡗࡓࠋࡲࡓ㸪ࣥࢻࡢBRVBࡣG5㸪I3㸪N2࠾ࡼࡧH6࡛
࠶ࡗࡓࡇࡼࡾࠊBRVBࡢVP7ࡣᑡ࡞ࡃࡶG3㸪G5ࡢ2ࡘࡢ㑇ఏᏊᆺࡀᏑ ᅾࡍࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋ
VP6 ࡢ࣑ࣀ㓟㓄ิᇶ࡙ࡃ⣔⤫ᶞ࡛ࡣ㸪ᡃࡀᅜࡢ BRVB ࡣ I3 㑇ఏᏊᆺ
ศ㢮ࡉࢀࡓࡀ㸪ࣥࢻࡢBRVBࡣᑡࡋ␗࡞ࡿศᒱࢆ♧ࡋࡓࠋࡋࡋ㸪VP6ࡢ
⣔⤫ゎᯒ⏝࠸ࡓ࣑ࣀ㓟㓄ิࡣ 126 ࣑ࣀ㓟࡛࠶ࡾ㸪㑇ఏᏊᆺูࢆ⾜࠺ࡢ
ࡣ༑ศᛮࢃࢀࡓࡓࡵ㸪⣔⤫ᶞࡢసᡂ༑ศ࡞㸪ࡼࡾ㛗࠸࣑ࣀ㓟㓄ิࢆᚓ
࡚ゎᯒࡍࡁ⪃࠼ࡽࢀࡓࠋ
NSP5ࡘ࠸࡚ࡣ㸪ᡃࡀᅜࡢBRVBࡣࣥࢻࡢBRVB␗࡞ࡿࢡࣛࢫࢱ࣮ࢆ
ᙧᡂࡋࡓࡀ㸪᪤ሗ࠶ࡿNSP5ᆺูࡢ࢝ࢵࢺ࢜ࣇ್ࡣሷᇶ࡛ࣞ࣋ࣝ78%࡛࠶ࡾ
㸦84㸧㸪ࡑࢀࢆᑡࡋୖᅇࡗࡓࡓࡵ㸪ࣥࢻࡢBRVBࡶH6㑇ఏᏊᆺᒓࡍ
ࡿุ᩿ࡉࢀࡓࠋNSP1ࡢ㑇ఏᏊᆺูࡣ㸪࣌ࣉࢳࢻ1࡛ࡣ࣑ࣀ㓟࡛ࣞ࣋ࣝ72㸣
࠾ࡼࡧ࣌ࣉࢳࢻ2࡛ࡣ࣑ࣀ㓟࡛ࣞ࣋ࣝ80㸣ࡢ࢝ࢵࢺ࢜ࣇ್ࡀタᐃࡉࢀ࡚࠸ࡿ
ࡀ㸦82㸧㸪ᡃࡀᅜࡢBRVBࡣ࣌ࣉࢳࢻ2࡛ࣄࢶࢪࡢRVBࡢA3㑇ఏᏊᆺ67.9 㹼68.8%ࡢ┦ྠᛶࢆ♧ࡋࡓࠋࡋࡋ㸪BRVB G-2006ᰴࡣࣄࢶࢪᰴ࣌ࣉࢳࢻ1
࡛ 75.2%ࡢ┦ྠᛶࢆ♧ࡋࡓࠋࡇࡢࡇࡽ㸪ᡃࡀᅜࡢBRVB ࡣA3 㑇ఏᏊᆺ
ศ㢮ࡉࢀࡿࡢࡶࡋࢀ࡞࠸ࠋᮏ❶࡛ࡣࠊゎᯒࡋࡓBRVBᰴࡢVP3ࠊNSP3࠾ࡼ
52
ࡧ NSP4 ࡢ࣑ࣀ㓟㓄ิᇶ࡙ࡁࠊࡑࢀࡒࢀࢆ M1-M4ࠊT1-T4 ࠾ࡼࡧ E1-E4 ࡢ㑇ఏᏊᆺ௬ศ㢮ࡋࡓࠋࡑࡢୖ࡛ࠊྠศ㢮ᇶ࡙ࡁࠊྛ㑇ఏᏊᆺࢆ༊ูࡍ
ࡿ┦ྠᛶࡢᇶ‽࡞ࡿ࢝ࢵࢺ࢜ࣇ್ࢆୖグࡢྛ⺮ⓑ㉁ࡘ࠸࡚ᥦၐࡋࡓࠋࡋ
ࡋ⌧ᅾࡢࡇࢁࢹ࣮ࢱ࣮࣋ࢫࡽධᡭ࡛ࡁࡿVP3㸪NSP3࠾ࡼࡧ NSP4ࡢ㑇ఏ Ꮚ㓄ิࡢᩘࡣᑡ࡞ࡃ㸪࢝ࢵࢺ࢜ࣇ್ࢆᐃࡵࡿࡣ༑ศ⪃࠼ࡽࢀࡿࡓࡵ㸪
ᚋከࡃࡢ㑇ఏᏊࢹ࣮ࢱࡢ✚ࡀᚲせ⪃࠼ࡽࢀࡓࠋ
ᅇ㸪BRVB ࡢ VP3㸪NSP3࠾ࡼࡧ NSP4 ࡣࡢ RVBࡢ㑇ఏᏊ㓄ิࡣ
࡞ࡾ␗࡞ࡿࡇࡀุ᫂ࡋࡓࠋࡋࡋ࡞ࡀࡽ㸪ࡑࢀࡒࢀࡢ࢘ࣝࢫ⺮ⓑ㉁࠾ࡅ
ࡿ≉ᚩⓗ࡞ࣔࢳ࣮ࣇࡸศᏊ⏕≀Ꮫⓗ࡞ᛶ㉁ࡀ㸪RVB ࡢᰴ㛫ಖᏑࡉࢀ࡚࠸ࡿࡇ
ࡀド᫂ࡉࢀࡓࠋࡲࡓ㸪ᡃࡀᅜ࠾ࡼࡧࣥࢻࡢ BRVB ࡣ, ࡚ࡢ㑇ఏᏊࢭࢢ࣓
ࣥࢺ࠾࠸࡚ࡢRVBࡣ␗࡞ࡿ⣔⤫ࢢ࣮ࣝࣉࢆᙧᡂࡍࡿࡇࡀࢃࡗࡓࠋ
ᅇ㸪᪂ࡓᚓࡽࢀࡓBRVBࡢ㑇ఏᏊሗࡣ㸪RVBࡢศᏊ⏕≀Ꮫⓗゎ᫂ࡍࡿୖ
࡛᭷⏝࡛࠶ࡿ⪃࠼ࡽࢀࡓࠋ
53
Accession No. Strain Region
LC185660 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] VP3 LC185661 RVB/Cow-wt/JPN/IS-2/2002/G3P[X] VP3 LC185662 RVB/Cow-wt/JPN/D-2002/2002/G3P[X] VP3 LC185663 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] VP3 LC185664 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] VP3 LC185665 RVB/Cow-wt/JPN/E-2005/2005/G3P[X] VP3 LC185666 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] VP3 LC185667 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] VP3 LC185668 RVB/Cow-wt/JPN/P-2011/2011/G3P[X] VP3 LC185669 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] NSP3 LC185670 RVB/Cow-wt/JPN/IS-2/2002/G3P[X] NSP3 LC185671 RVB/Cow-wt/JPN/D-2002/2002/G3P[X] NSP3 LC185672 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] NSP3 LC185673 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] NSP3 LC185674 RVB/Cow-wt/JPN/E-2005/2005/G3P[X] NSP3 LC185675 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] NSP3 LC185676 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] NSP3 LC185677 RVB/Cow-wt/JPN/P-2011/2011/G3P[X] NSP3 LC185678 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] NSP4 LC185679 RVB/Cow-wt/JPN/IS-2/2002/G3P[X] NSP4 LC185680 RVB/Cow-wt/JPN/D-2002/2002/G3P[X] NSP4 LC185681 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] NSP4 LC185682 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] NSP4 LC185683 RVB/Cow-wt/JPN/E-2005/2005/G3P[X] NSP4 LC185684 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] NSP4 LC185685 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] NSP4 LC185686 RVB/Cow-wt/JPN/P-2011/2011/G3P[X] NSP4 LC185687 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] VP7 LC185688 RVB/Cow-wt/JPN/IS-2/2002/G3P[X] VP7 LC185689 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] VP7 LC185690 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] VP7 LC185691 RVB/Cow-wt/JPN/P-2011/2011/G3P[X] VP7 LC185692 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] VP4 LC185693 RVB/Cow-wt/JPN/IS-2/2002/G3P[X] VP4 LC185694 RVB/Cow-wt/JPN/D-2002/2002/G3P[X] VP4 LC185695 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] VP4 LC185696 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] VP4 LC185697 RVB/Cow-wt/JPN/E-2005/2005/G3P[X] VP4 LC185698 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] VP4 LC185699 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] VP4 LC185700 RVB/Cow-wt/JPN/P-2011/2011/G3P[X] VP4 LC185701 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] VP6 LC185702 RVB/Cow-wt/JPN/IS-2/2002/G3P[X] VP6 LC185703 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] VP1 LC185704 RVB/Cow-wt/JPN/IS-2/2002/G3P[X] VP1 LC185705 RVB/Cow-wt/JPN/IS-2/2002/G3P[X] VP2 LC185706 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] VP2 LC185707 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] NSP1 LC185708 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] NSP1 LC185709 RVB/Cow-wt/JPN/IS-1/1999/G3P[X] NSP2 LC185710 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] NSP2 LC185711 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] NSP5 LC185712 RVB/Cow-wt/JPN/P-2011/2011/G3P[X] NSP5
ᅗ⾲ ⾲
3-1 ▼ᕝ┴᳨࡛ฟࡉࢀࡓBRVBࡢྛ㑇ఏᏊࢭࢢ࣓ࣥࢺDDBJ/EMBL/GenBankࢡࢭࢵࢩࣙࣥ␒ྕ
54
150 RVB/Cow-wt/JPN/IS-1/1999/G3P[X} M S K L I E F SD L G I E V T N R EQ L F K I SN N T S SY E T I R P S KD I ED Y I R E S SH Y V V I D KR R N E P F V E V F T Q L F P S S I VY N H K EGY K SG GC R H L L N N V L H V SN Y MH T Y C N S N T R N L A PD GW T I D K AD E F D D P I GD Y I L R SM VN D C SM EN K AQH R H K RVB/Cow-wt/JPN/IS-2/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/P-2011/2011]/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉E䞉 䞉 䞉L䞉 䞉K V䞉 䞉F䞉V䞉K䞉T䞉G䞉 䞉 䞉 䞉 䞉QN䞉T䞉 䞉 䞉T䞉 䞉R䞉T䞉D E V S K䞉L D T䞉 䞉 䞉T䞉V I S N N E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉D䞉I䞉 䞉 䞉 䞉SH䞉 䞉S䞉L䞉R䞉D Q SW L䞉T䞉 䞉S V S EC䞉G L䞉 䞉H V䞉 䞉Q䞉I KR I䞉 䞉T䞉 䞉K Q T䞉G䞉I KN L RVB/Human-wt/CHN/WH-1/2002/G2P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉D䞉 䞉 䞉F K V䞉K䞉T A A䞉K䞉 䞉 䞉G T䞉T䞉 䞉 䞉V L䞉R䞉D䞉D E T AD䞉L䞉T䞉 䞉 䞉T䞉V I F N C E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉T䞉 䞉I䞉D G䞉F S䞉G VN S I Q䞉W I䞉R䞉 䞉 䞉V䞉 䞉C䞉R L䞉 䞉H V䞉 䞉 䞉 䞉I K L L䞉D S䞉 䞉S Q T VR EMN KM RVB/Human-wt/SEN/MRC-DPRU4680/2010/G2P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉D䞉 䞉 䞉F K I䞉K䞉T A A䞉K䞉 䞉 䞉G T䞉T䞉 䞉 䞉V L䞉R䞉D䞉D E T AD䞉L䞉T䞉 䞉 䞉T䞉V I F N C E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉I䞉D G䞉F S䞉G VN S I Q䞉W I䞉R䞉 䞉I V䞉 䞉C䞉R L䞉 䞉H V䞉 䞉 䞉 䞉I K L L䞉D S䞉 䞉S Q T I R EMN KM RVB/Human-wt/IND/IDH-084/2007/G2P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉D䞉 䞉 䞉F K I䞉K䞉T A A䞉K䞉 䞉 䞉G T䞉T䞉 䞉 䞉V L䞉R䞉D䞉D E T AD䞉L A T䞉 䞉 䞉T䞉V I F N C E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉I䞉D G䞉F S䞉G VN S I Q䞉W I䞉R䞉 䞉I V䞉 䞉C䞉R L䞉 䞉H V䞉 䞉 䞉 䞉I K L L䞉D S䞉 䞉S Q T I R EMN KM RVB/Human-wt/IC-008/2008/G2P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉D䞉 䞉 䞉F K I䞉K䞉T A A䞉K䞉 䞉 䞉G T䞉T䞉 䞉 䞉V L䞉R䞉D䞉D E T AD䞉L䞉T䞉 䞉 䞉T䞉V I F N C E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉I䞉D G䞉F S䞉G VN S I Q䞉W I䞉R䞉 䞉I V䞉 䞉C䞉R L䞉 䞉H V䞉 䞉 䞉 䞉I K L L䞉D S䞉 䞉S Q T I R EMN K V RVB/Human-wt/MMR/MMR-B1/2007/G2P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉D䞉 䞉 䞉F K I䞉K䞉T A A䞉K䞉 䞉 䞉G T䞉T䞉 䞉 䞉V L䞉R䞉D䞉D E T AD䞉L䞉T䞉 䞉 䞉T䞉V I F N C E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉I䞉D G䞉F S䞉G VN S I Q䞉W I䞉R䞉 䞉I V䞉 䞉C䞉R L䞉 䞉H V䞉 䞉 䞉 䞉I K L L䞉D S䞉 䞉S Q T I R EMN KM RVB/Human-wt/IND/CAL-1/1998/G2P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉D䞉 䞉 䞉F K I䞉K䞉T A A䞉K䞉 䞉 䞉G T䞉T䞉 䞉 䞉V L䞉R䞉D䞉D E T AD䞉L䞉T䞉 䞉 䞉T䞉V I F N C E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉I䞉D G䞉F S䞉G VN S I Q䞉W I䞉R䞉 䞉I V䞉 䞉C䞉R L䞉 䞉H V䞉 䞉 䞉 䞉I K L L䞉D S䞉 䞉S Q T I R EMN N M RVB/Human-wt/BGD/Bang373/2000/G2P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉D䞉 䞉 䞉F K I䞉K䞉T V A䞉K䞉 䞉 䞉G T䞉T䞉 䞉 䞉V L䞉R䞉D䞉D E T AD䞉L䞉T䞉 䞉 䞉T䞉V I F N C E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉I䞉D G䞉F S䞉G VN S I Q䞉W I䞉R䞉 䞉I V䞉 䞉C䞉R L䞉 䞉H V䞉 䞉 䞉 䞉I K L L䞉D S䞉 䞉S Q T I R EMN KM RVB/Human-wt/GBD/Bang117/2002/G2P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉D䞉 䞉 䞉F K I䞉K䞉T V A䞉K䞉 䞉 䞉G T䞉T䞉 䞉 䞉V L䞉R䞉D䞉D E T AD䞉L䞉T䞉 䞉 䞉T䞉V I F N C E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉I䞉D G䞉F S䞉G VN S I Q䞉W I䞉R䞉 䞉I V䞉 䞉C䞉R L䞉 䞉H V䞉 䞉 䞉 䞉I K L L䞉D S䞉 䞉S Q T I R EMN KM RVB/Rat-hhpUSA/IDIR/1984/G1P[X] 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉 䞉A䞉I S䞉 䞉 䞉D䞉 䞉 䞉L䞉 䞉 䞉V䞉 䞉F䞉I V䞉 䞉T T N䞉K䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉T䞉 䞉R䞉D䞉 䞉E AGD䞉L䞉T䞉 䞉 䞉T䞉V I S D S E䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉D䞉 䞉 䞉S䞉L GR D V Q S I T䞉T䞉 䞉N V䞉L C䞉KY䞉 䞉P V䞉 䞉 䞉V䞉K L I䞉 䞉E䞉 䞉C Q T VR䞉M䞉N S
* * * * * * . * * * * . * : : * * * : * * * : * * . . * * : : : . * : * : * * * * : * * * . : * . * * : . : : * * * : * : : * : * * * * * * * * * * * * * * : * . * . : * . . . * * * : . : . * : * * : * * : . : * : * * : . : . : 300 RVB/Cow-wt/JPN/IS-1/1999/G3P[X} PN G VY P K L L N I N E F F I K T L KR M I T P V S N VD F Q S Y H Y L N Q R R Q I G T L VR N T I F E L I AN N NWN VN Y I G P E F E S F R N I C E L L L N R N Y T G K I R F F T F N S S I QH D Y K KQ L S S F H R E K VDWD Y VH R Y R L K F EN A F C H L F L H H I I K SR SY S I I Y VN T RVB/Cow-wt/JPN/IS-2/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/P-2011/2011]/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] K P䞉T䞉 䞉 䞉 䞉E G V䞉D V䞉KN F䞉T E I T䞉 䞉Q T H䞉 䞉 䞉 䞉 䞉 䞉N䞉M V䞉 䞉K䞉 䞉 䞉Y V䞉 䞉K䞉V䞉Y䞉 䞉R K Y䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KD䞉I L䞉 䞉T D䞉E䞉 䞉 䞉 䞉F I T Y䞉L䞉T䞉K K䞉N䞉R E K E R E Y N S Q䞉A䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉L F N䞉V AQQ䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉S RVB/Human-wt/CHN/WH-1/2002/G2P[X] K P䞉T䞉 䞉 䞉M E R V E䞉E䞉T N F䞉 䞉K䞉T䞉 䞉Q K E I䞉 䞉 䞉 䞉 䞉N䞉A V䞉 䞉 䞉 䞉 䞉 䞉Y V䞉 䞉K䞉V䞉S䞉 䞉K S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I N䞉 䞉T D䞉 䞉 䞉 䞉 䞉 䞉F V T䞉 䞉 䞉 䞉 䞉 䞉K S䞉N䞉 䞉H R V K E Y L N K䞉AG䞉N䞉 䞉 䞉 䞉M䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉I Y N䞉VM䞉Q䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 RVB/Human-wt/SEN/MRC-DPRU4680/2010/G2P[X] R P䞉T䞉 䞉R M E R V E䞉E䞉T N F䞉 䞉K䞉T䞉 䞉Q K E I䞉 䞉 䞉 䞉 䞉N䞉A V䞉 䞉 䞉 䞉 䞉 䞉Y V䞉 䞉K䞉V䞉S䞉 䞉K S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I N䞉 䞉T D K䞉 䞉 䞉 䞉 䞉F V T䞉 䞉 䞉 䞉 䞉 䞉K K䞉S䞉 䞉H H I R E Y L N E䞉AG䞉N䞉 䞉 䞉 䞉M䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉I Y N䞉V A䞉Q䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 RVB/Human-wt/IND/IDH-084/2007/G2P[X] R P䞉T䞉 䞉R M E R V E䞉E䞉T N F䞉 䞉K䞉T䞉 䞉Q K E I䞉 䞉 䞉 䞉 䞉N䞉A V䞉 䞉 䞉 䞉 䞉 䞉Y V䞉 䞉K䞉V䞉S䞉 䞉K S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I N䞉 䞉T D K䞉 䞉 䞉 䞉 䞉F V T䞉 䞉 䞉 䞉 䞉 䞉K K䞉S䞉 䞉H H I R E Y L N E䞉AG䞉N䞉 䞉 䞉 䞉M䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉I Y N䞉V A䞉Q䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 RVB/Human-wt/IC-008/2008/G2P[X] R P䞉T䞉 䞉R M E R V E䞉E䞉T N F䞉 䞉K䞉T䞉 䞉Q K E I䞉 䞉 䞉 䞉 䞉N䞉A V䞉 䞉 䞉 䞉 䞉 䞉Y V䞉 䞉K䞉V䞉S䞉 䞉K S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I N䞉 䞉T D K䞉 䞉 䞉 䞉 䞉F V T䞉 䞉 䞉 䞉 䞉 䞉K K䞉S䞉 䞉H H I R E Y L N E䞉AG䞉N䞉 䞉 䞉 䞉M䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉I Y N䞉V A䞉Q䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 RVB/Human-wt/MMR/MMR-B1/2007/G2P[X] R P䞉T䞉 䞉R M E R V E䞉E䞉T N F䞉 䞉K䞉T䞉 䞉Q K E I䞉 䞉 䞉 䞉 䞉N䞉A V䞉 䞉 䞉 䞉 䞉 䞉Y V䞉 䞉K䞉V䞉S䞉 䞉K S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I N䞉 䞉T D K䞉 䞉 䞉 䞉 䞉F V T䞉 䞉 䞉 䞉 䞉 䞉K K䞉S䞉 䞉H H I R E Y L N E䞉AG䞉N䞉 䞉 䞉 䞉M䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉I Y N䞉V A䞉Q䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 RVB/Human-wt/IND/CAL-1/1998/G2P[X] R P䞉T䞉 䞉R M E R V E䞉E䞉T N F䞉 䞉K䞉T䞉 䞉Q K E I䞉 䞉 䞉 䞉 䞉N䞉A V䞉 䞉 䞉 䞉 䞉 䞉Y V䞉 䞉K䞉V䞉S䞉 䞉K S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I N䞉 䞉I D K䞉 䞉 䞉 䞉 䞉F V T䞉 䞉 䞉 䞉 䞉 䞉K K䞉S䞉 䞉H Y I R E Y L N K䞉AG䞉N䞉 䞉 䞉 䞉M䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉L Y N䞉V A䞉Q䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 RVB/Human-wt/BGD/Bang373/2000/G2P[X] R P䞉T䞉 䞉R M E R V E䞉E䞉T N F䞉 䞉K䞉T䞉 䞉Q K E I䞉 䞉 䞉 䞉 䞉N䞉A V䞉 䞉 䞉 䞉 䞉 䞉Y V䞉 䞉K䞉V䞉S䞉 䞉K S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I N䞉 䞉T D K䞉 䞉 䞉 䞉 䞉F I T䞉 䞉 䞉 䞉 䞉 䞉K K䞉S䞉 䞉H H I R E Y L N K䞉AG䞉N䞉 䞉 䞉 䞉M䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉I Y N䞉V A䞉Q䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 RVB/Human-wt/GBD/Bang117/2002/G2P[X] R P䞉T䞉 䞉R M E R V E䞉E䞉T N F䞉 䞉K䞉T䞉 䞉Q K E I䞉 䞉 䞉 䞉 䞉N䞉A V䞉 䞉 䞉 䞉 䞉 䞉Y V䞉 䞉K䞉V䞉S䞉 䞉K S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I N䞉 䞉T D K䞉 䞉 䞉 䞉 䞉F I T䞉 䞉 䞉 䞉 䞉 䞉K K䞉S䞉 䞉H H I R E Y L N K䞉AG䞉N䞉 䞉 䞉 䞉M䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉I Y N䞉V A䞉Q䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 RVB/Rat-hhpUSA/IDIR/1984/G1P[X] R P䞉T䞉 䞉A V K S V䞉E K䞉T E F䞉 䞉H䞉T䞉 䞉Q T A I䞉 䞉 䞉 䞉 䞉N䞉L T䞉 䞉 䞉 䞉 䞉SY V T䞉K T V䞉R䞉 䞉S A䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K E䞉I K䞉 䞉T D K S䞉 䞉 䞉 䞉F I PY䞉 䞉 䞉T䞉R D䞉D䞉N K T E R QY S S S M A䞉 䞉N F䞉 䞉 䞉W䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉Q䞉L F R䞉V I KQ䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉A
* . * * . : : : : * : * . : * * . : * * * * * : * * * . * * . : . * : * : * * * . * * * * * * * * * * * * * * . : * * * : . : * * * * : : * : * : * . * . * . . : : * . . * : : * * * * * : * * * * * : * : : * : : . * * * * * * * * : 450 RVB/Cow-wt/JPN/IS-1/1999/G3P[X} L Y N I GNW T E A Y PW L N I R V VD H I P V I L N N S V V F G F M L S T N AC S F S V N VD S D R V VY S P K PY D D EN N VW T V S I L G EN I G V P SN E A E R I A A K KN G L P N Y I Y GG V K F D V E A L D F N Y V T VG L Y S L SN V I N S P E L I K A T L SY D H I F T F P T Y S EG DWR RVB/Cow-wt/JPN/IS-2/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉P䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/P-2011/2011]/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] 䞉 䞉 䞉V䞉 䞉 䞉V T䞉 䞉S䞉 䞉 䞉I N䞉 䞉 䞉 䞉L䞉T䞉Q K䞉 䞉 䞉I䞉 䞉 䞉L䞉 䞉S K D䞉 䞉 䞉 䞉 䞉 䞉T L䞉 䞉I䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉Y䞉 䞉 䞉 䞉 䞉M䞉 䞉F䞉 䞉C L䞉D䞉E S䞉 䞉 䞉E䞉T䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A䞉 䞉 䞉 䞉L䞉R I䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉S F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉D䞉N䞉 䞉 RVB/Human-wt/CHN/WH-1/2002/G2P[X] 䞉 䞉 䞉V䞉 䞉 䞉 䞉K䞉 䞉E䞉 䞉D I N䞉 䞉 䞉R L䞉 䞉 䞉Q K䞉 䞉I䞉 䞉 䞉Y䞉 䞉 䞉S K E䞉 䞉 䞉 䞉I䞉 䞉E䞉 䞉L䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉M䞉 䞉 䞉 䞉 䞉M䞉D K L䞉T VY䞉 䞉D D䞉 䞉 䞉 䞉 䞉A䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A A䞉 䞉R䞉D䞉 䞉N I A䞉 䞉 䞉 䞉 䞉 䞉S V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉K䞉 䞉 䞉 䞉 RVB/Human-wt/SEN/MRC-DPRU4680/2010/G2P[X] 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉D I N䞉 䞉 䞉 䞉L䞉 䞉 䞉Q K䞉 䞉I I䞉 䞉Y䞉 䞉 䞉S K E䞉 䞉 䞉 䞉 䞉 䞉 䞉E䞉 䞉L䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉 䞉 䞉 䞉 䞉 䞉 䞉M䞉N K L䞉T T Y䞉 䞉D D䞉 䞉 䞉V䞉T䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A A䞉 䞉K䞉D䞉I N I A䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉K䞉 䞉 䞉 䞉 RVB/Human-wt/IND/IDH-084/2007/G2P[X] 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉D I N䞉 䞉 䞉 䞉L䞉 䞉 䞉Q K䞉 䞉I I䞉 䞉Y䞉 䞉 䞉S K E䞉 䞉 䞉 䞉 䞉 䞉 䞉E䞉 䞉L䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉 䞉 䞉 䞉 䞉 䞉 䞉M䞉N K L䞉T T Y䞉 䞉D D䞉 䞉 䞉V䞉T䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A A䞉 䞉K䞉D䞉I N I A䞉 䞉 䞉 䞉 䞉 䞉S V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉P䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉K䞉 䞉 䞉 䞉 RVB/Human-wt/IC-008/2008/G2P[X] 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉D I N䞉 䞉 䞉 䞉L䞉 䞉 䞉Q K䞉 䞉I I䞉 䞉Y䞉 䞉 䞉S K E䞉 䞉 䞉 䞉 䞉 䞉 䞉E䞉 䞉L䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉 䞉 䞉 䞉 䞉 䞉 䞉M䞉N K L䞉T T Y䞉 䞉D D䞉 䞉 䞉V䞉T䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A A䞉 䞉K䞉D䞉I N I A䞉 䞉 䞉 䞉 䞉 䞉S V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉K䞉 䞉 䞉 䞉 RVB/Human-wt/MMR/MMR-B1/2007/G2P[X] 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉D I N䞉 䞉 䞉 䞉L䞉 䞉 䞉Q K䞉 䞉I I䞉 䞉Y䞉 䞉 䞉S K E䞉 䞉 䞉 䞉 䞉 䞉 䞉E䞉 䞉L䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉 䞉 䞉 䞉 䞉 䞉 䞉M䞉N K L䞉T T Y䞉 䞉D D䞉 䞉 䞉V䞉T䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A A䞉 䞉K䞉D䞉I N I A䞉 䞉 䞉 䞉 䞉 䞉S V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉K䞉 䞉 䞉 䞉 RVB/Human-wt/IND/CAL-1/1998/G2P[X] 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉D I N䞉 䞉 䞉 䞉L䞉 䞉 䞉Q K䞉 䞉I I䞉 䞉Y䞉 䞉 䞉S K E䞉 䞉 䞉 䞉 䞉 䞉A E䞉 䞉L䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉 䞉 䞉 䞉 䞉 䞉 䞉M䞉N K L䞉T T Y䞉 䞉D D䞉 䞉 䞉V䞉T䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A A䞉 䞉K䞉D䞉I N I A䞉 䞉 䞉 䞉 䞉 䞉S V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉K䞉 䞉 䞉 䞉 RVB/Human-wt/BGD/Bang373/2000/G2P[X] 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉D I N䞉 䞉 䞉 䞉L䞉 䞉 䞉Q K䞉 䞉I I䞉 䞉Y䞉 䞉 䞉S K E䞉 䞉 䞉 䞉 䞉 䞉A E䞉 䞉L䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉 䞉 䞉 䞉 䞉 䞉 䞉M䞉N K L䞉T T Y䞉 䞉D D䞉 䞉 䞉V䞉T䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A A䞉 䞉K䞉D䞉I N I A䞉 䞉 䞉 䞉 䞉 䞉S V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉K䞉 䞉 䞉 䞉 RVB/Human-wt/GBD/Bang117/2002/G2P[X] 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉D I N䞉 䞉 䞉 䞉L䞉 䞉 䞉Q K䞉 䞉I I䞉 䞉Y䞉 䞉 䞉S K E䞉 䞉 䞉 䞉 䞉 䞉A E䞉 䞉L䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉D S䞉 䞉 䞉 䞉 䞉 䞉 䞉M䞉N K L䞉T T Y䞉 䞉D D䞉 䞉 䞉V䞉T䞉N䞉 䞉 䞉 䞉V F䞉 䞉 䞉P F T A A䞉 䞉K䞉D䞉I N I A䞉 䞉 䞉 䞉 䞉 䞉S V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉K䞉 䞉 䞉 䞉 RVB/Rat-hhpUSA/IDIR/1984/G1P[X] 䞉 䞉 䞉V䞉 䞉 䞉V S G䞉P䞉 䞉Q I N䞉 䞉 䞉 䞉L䞉 䞉 䞉Q K䞉 䞉V V䞉 䞉 䞉L䞉S S S D䞉 䞉 䞉 䞉A䞉 䞉E T E T䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉 䞉M䞉Q K䞉 䞉A K䞉 䞉D Q S䞉 䞉 䞉A䞉M䞉N䞉A䞉 䞉V F䞉 䞉 䞉P F T A E䞉 䞉Q䞉N䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉 䞉 䞉T V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉 䞉N䞉N䞉 䞉
* * * : * * * . . * * * : * . * * * . : * . * : * * : : * * : : * : : : * * * * : * . . : * * * * * . * * * * : . * * * * * * : * : : * : : * * * * * . * : * * : : * * * * . * * : : : . : . * * * * * * . * * * * * * * * . * * * : * * * * * * : * * . * : * * 600 RVB/Cow-wt/JPN/IS-1/1999/G3P[X} L E I E K T N K I F I T T QR Q F K F N DW I I D A K N L S L EMD T E V V S E S V F L Q L G KD R A F I SD R Y QH M V A F R F KQ KN Y Y SD R Y M SH L G I R Q P S I F N R D R F L T S R L S A Y I D R Q L T L N SD L S L I E KN H F SG F S GH L I A V E KY F H A L T Y T M S PMRW AN R A L RVB/Cow-wt/JPN/IS-2/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/P-2011/2011]/G3P[X] 䞉 䞉I䞉 䞉 䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉L N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉R䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] D䞉R P䞉H D䞉 䞉 䞉 䞉 䞉 䞉E K䞉L R䞉E䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉N A䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉PH䞉 䞉 䞉 䞉T䞉M F䞉 䞉L I S䞉 䞉 䞉 䞉 䞉E䞉F F䞉 䞉Q䞉 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉QY䞉S䞉 䞉 䞉N䞉 䞉M S䞉 䞉 䞉 䞉 䞉G I䞉 䞉T V䞉K䞉 䞉N䞉A䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉L䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Human-wt/CHN/WH-1/2002/G2P[X] D䞉R P T T D N䞉 䞉V䞉 䞉E K䞉L R䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉F䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉K䞉F F䞉 䞉Q K F䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉I Y䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉S T䞉 䞉 䞉 䞉 䞉KQ䞉N䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉R䞉 䞉 䞉 RVB/Human-wt/SEN/MRC-DPRU4680/2010/G2P[X] D䞉R A T T D D䞉 䞉V䞉 䞉E K䞉L R䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉F䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉K䞉F F䞉 䞉Q K F䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉I Y䞉S䞉 䞉 䞉N䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉S T䞉 䞉 䞉 䞉 䞉KQ䞉N䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 RVB/Human-wt/IND/IDH-084/2007/G2P[X] D䞉R A T T D D䞉 䞉V䞉 䞉E K䞉L R䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉F䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉K䞉F F䞉 䞉Q K F䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉I Y䞉S䞉 䞉 䞉N䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉S T䞉 䞉 䞉 䞉 䞉KQ䞉N䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 RVB/Human-wt/IC-008/2008/G2P[X] D䞉R A T T D D䞉 䞉V䞉 䞉E K䞉L R䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉F䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉K䞉F F䞉 䞉Q K F䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉I Y䞉S䞉 䞉 䞉N䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉S T䞉 䞉 䞉 䞉 䞉KQ䞉N䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 RVB/Human-wt/MMR/MMR-B1/2007/G2P[X] D䞉R A T T D D䞉 䞉V䞉 䞉E K䞉L R䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉F䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉K䞉F F䞉 䞉Q K F䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉I Y䞉S䞉 䞉 䞉N䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉S T䞉 䞉 䞉 䞉 䞉KQ䞉N䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 RVB/Human-wt/IND/CAL-1/1998/G2P[X] D䞉R A T T D D䞉 䞉V䞉 䞉E K䞉L R䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉F䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉K䞉F F䞉 䞉Q K F䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉I Y䞉S䞉 䞉 䞉N䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉S T䞉 䞉 䞉 䞉 䞉KQ䞉N䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 RVB/Human-wt/BGD/Bang373/2000/G2P[X] D䞉R A T T D D䞉 䞉V䞉 䞉E K䞉L R䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉F䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉K䞉F F䞉 䞉Q K F䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉I Y䞉S䞉 䞉 䞉N䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉S T䞉 䞉 䞉 䞉 䞉KQ䞉N䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 RVB/Human-wt/GBD/Bang117/2002/G2P[X] D䞉R A T T D D䞉 䞉V䞉 䞉E K䞉L R䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉F䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉K䞉F F䞉 䞉Q K F䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉I Y䞉S䞉 䞉 䞉N䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉S T䞉 䞉 䞉 䞉 䞉KQ䞉N䞉E䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 RVB/Rat-hhpUSA/IDIR/1984/G1P[X] D䞉R R MH D D䞉 䞉VG Q E K䞉L R䞉E䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉F䞉SH䞉 䞉 䞉 䞉 䞉 䞉M䞉 䞉 䞉L I S䞉 䞉 䞉 䞉 䞉N䞉F F䞉 䞉Q K M䞉 䞉L䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉I Y䞉S䞉 䞉 䞉N䞉 䞉MN䞉 䞉 䞉 䞉 䞉N S䞉 䞉 䞉K䞉R Q䞉N䞉A䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉
* . : . * * : : : : . * : . * : * * : * * * * * * : * * : : . * * * * * : * * * * : * * * * * : * : * * : : : * * * * * : * : : * * . : * * : * * * * * * * . * * * : * : * * * . * * : . * * * * * . * * : : * : : * : * * * * * * * * * * : * * * * * * . * * * * * : * * * . * * * 750 RVB/Cow-wt/JPN/IS-1/1999/G3P[X} SD A I Y K K T D RW T N A A G ER H S I Q D F R N T Y AY L GD S I N P I F R SN L V T N KY A D K P T H C I Q L L S K KN H I T L Q L T T T S P D R AM P L V I K A V E G T R F KY L G R N K F G T MD V A L Y Q T D GM T QY E I V N I L R T MD I PC QQ T R P Y I MH M T I KD Q SD I P S T I V RVB/Cow-wt/JPN/IS-2/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/P-2011/2011]/G3P[X] 䞉 䞉 䞉F䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉R䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉L䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉Q䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] 䞉 䞉 䞉 䞉 䞉R䞉H䞉N F S䞉 䞉V䞉 䞉 䞉 䞉T L D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉L KY K䞉 䞉N䞉 䞉 䞉 䞉 䞉E䞉KY A䞉M䞉MC GN䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KD䞉S N L L T E I GN L䞉H䞉L N I䞉 䞉 䞉 䞉K䞉S䞉 䞉S I N L䞉 䞉 䞉 䞉 䞉K E䞉I䞉 䞉K L S䞉L䞉 䞉S F䞉 䞉A䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉L䞉 䞉D KN䞉 䞉N I䞉 䞉 RVB/Human-wt/CHN/WH-1/2002/G2P[X] 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉V F S䞉 䞉I䞉D䞉 䞉 䞉L H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉 䞉D䞉K F A䞉M䞉SC G V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KN䞉Q I䞉L Q E I GN䞉 䞉H䞉M V I䞉K䞉 䞉 䞉 䞉D䞉 䞉S I K䞉I䞉 䞉 䞉 䞉K E䞉I䞉 䞉K䞉C䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T EC N V䞉D V V I RVB/Human-wt/SEN/MRC-DPRU4680/2010/G2P[X] 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉S F S䞉 䞉I䞉D䞉 䞉 䞉L H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉 䞉D䞉K F A䞉T䞉SC G A䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KN䞉Q I䞉L Q E I GN T I H䞉M V I䞉K䞉D K䞉D䞉 䞉N I K䞉I䞉 䞉 䞉 䞉KD䞉I䞉 䞉K䞉C䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉T E䞉N V䞉D V䞉I RVB/Human-wt/IND/IDH-084/2007/G2P[X] 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉S F S䞉 䞉I䞉D䞉 䞉 䞉L H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉 䞉D䞉K F A䞉T䞉SC G V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KN䞉Q I䞉L Q E I GN T I H䞉M V I䞉K䞉D K䞉D䞉 䞉N I K䞉I䞉 䞉 䞉 䞉KD䞉I䞉 䞉K䞉C䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉T E䞉N V䞉D V䞉I RVB/Human-wt/IC-008/2008/G2P[X] 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉S F S䞉 䞉I䞉D䞉 䞉 䞉L H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉 䞉D䞉K F A䞉T䞉SC G V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KN䞉Q I䞉L Q E I GN T I H䞉M V I䞉K䞉D K䞉D䞉 䞉N I K䞉V䞉 䞉 䞉 䞉KD䞉I䞉 䞉K䞉C䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉T E䞉N V䞉D V䞉I RVB/Human-wt/MMR/MMR-B1/2007/G2P[X] 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉S F S䞉 䞉I䞉D䞉 䞉 䞉L H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉 䞉D䞉K F A䞉T䞉SC G V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KN䞉Q I䞉L Q E I GN T I H䞉M V I䞉K䞉D K䞉D䞉 䞉N I K䞉I䞉 䞉 䞉 䞉KD䞉I䞉 䞉K䞉C䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T E䞉N V䞉D V䞉I RVB/Human-wt/IND/CAL-1/1998/G2P[X] 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉S F S䞉 䞉I䞉D䞉 䞉 䞉L H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉 䞉D䞉K F A䞉T䞉SC G V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KN䞉Q I䞉L Q E I GN T I H䞉M V I䞉K䞉D K䞉D䞉 䞉N I R䞉I䞉 䞉 䞉 䞉K E䞉I䞉 䞉K䞉C䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉T ER N V䞉D V䞉I RVB/Human-wt/BGD/Bang373/2000/G2P[X] 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉S F S䞉 䞉I䞉D䞉 䞉 䞉L H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉 䞉D䞉K F A䞉T䞉SC G V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KN䞉Q I䞉L QD I GN T I H䞉M V I䞉K䞉D K䞉D䞉 䞉N I K䞉I䞉 䞉 䞉 䞉K E䞉I䞉 䞉K䞉C䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉T ER N V䞉D V䞉I RVB/Human-wt/GBD/Bang117/2002/G2P[X] 䞉 䞉 䞉 䞉 䞉S䞉 䞉 䞉S F S䞉 䞉I䞉D䞉 䞉 䞉L H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉 䞉D䞉K F A䞉T䞉SC G V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KN䞉Q I䞉L QD I GN T I H䞉M V I䞉K䞉D K䞉D䞉 䞉N I K䞉I䞉 䞉 䞉 䞉K E䞉I䞉 䞉K䞉C䞉 䞉 䞉 䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉V䞉T ER N V䞉D V䞉I RVB/Rat-hhpUSA/IDIR/1984/G1P[X] 䞉 䞉 䞉V䞉S䞉 䞉 䞉I F S䞉 䞉I䞉E䞉 䞉 䞉 䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉T V䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉S䞉S䞉A L M䞉N C R T C䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉KD䞉E V䞉 䞉T K V K S V I H䞉M K L䞉F䞉 䞉F䞉R䞉 䞉N VR䞉A䞉 䞉 䞉 䞉T S䞉I䞉 䞉K䞉S䞉 䞉 䞉 䞉S F N䞉 䞉 䞉 䞉 䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉L R D D S K P䞉D V䞉L
* * * : * * * : : * * * : * * : : * * . * * * * * * * : : : * * * : . : * * . * * : * * . * . . . . * . . * * * * * * * * . . * . : : : : * : * * . . * . * * . : : * * * * . * * * : : * : * * : : : * . * * * * * * * * * * : : : : * . : : 763
RVB/Cow-wt/JPN/IS-1/1999/G3P[X} AN S N N V K V K E I R C RVB/Cow-wt/JPN/IS-2/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/E-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/D-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/G-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow-wt/JPN/P-2011/2011]/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] 䞉H R KD I K I䞉 䞉 䞉KH RVB/Human-wt/CHN/WH-1/2002/G2P[X] I䞉R䞉D L T I䞉 䞉 䞉KR RVB/Human-wt/SEN/MRC-DPRU4680/2010/G2P[X] I䞉R䞉D L I I䞉 䞉 䞉KR RVB/Human-wt/IND/IDH-084/2007/G2P[X] I䞉R䞉D L I I䞉 䞉 䞉KR RVB/Human-wt/IC-008/2008/G2P[X] I䞉R䞉D L I I䞉 䞉 䞉KR RVB/Human-wt/MMR/MMR-B1/2007/G2P[X] I䞉R䞉D L I I䞉 䞉 䞉KR RVB/Human-wt/IND/CAL-1/1998/G2P[X] I䞉R䞉D L I I䞉 䞉 䞉KR RVB/Human-wt/BGD/Bang373/2000/G2P[X] I䞉R䞉D L I I䞉 䞉 䞉KR RVB/Human-wt/GBD/Bang117/2002/G2P[X] I䞉R䞉D L I I䞉 䞉 䞉KR RVB/Rat-hhpUSA/IDIR/1984/G1P[X] V䞉E䞉D䞉Y S䞉 䞉 䞉KR : : : : : * * * .
GxxxE(S/T) motif
SGHΦ motif LΩxL(S/T)NxxN motif
ᅗ3-1 BRVB㸪ࣄࢺ࠾ࡼࡧ㇜ࣟࢱ࢘ࣝࢫBࡢVP3࣑ࣀ㓟㓄ิࡢẚ㍑
ࢻࢵࢺࡣୖẁྠࡌࡇࢆ♧ࡍ
55
RVB/Cow -w t/JPN/IS-1/1999/G3P[X] MA L NA V A S I L G SV L S K HE I DDQ L K I I E DF I HA MK DCGMML DNWRDA Y Y K L R I P K PMT G T T MA I Q L K NME T EV L RL RHE SWK NG E T MK DRL L Q S F DV G K K NGY T V L L P K T RNA EV V L L NS T RVB/Cow -w t/JPN/IS-2/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/D-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/E-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/D-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/E-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/D-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/G-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉Y䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/P-2011/2011/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉R䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] 䞉 䞉 䞉 䞉V䞉V䞉V䞉 䞉 䞉 䞉 䞉D䞉F Q䞉 䞉NS K E䞉 䞉DE䞉K S䞉L E䞉 䞉 䞉I K I䞉E䞉 䞉 䞉 䞉 䞉 䞉Q E䞉 䞉 䞉 䞉 䞉 䞉S S䞉S䞉 䞉 䞉 䞉 䞉 䞉 䞉F䞉V䞉 䞉 䞉Q䞉 䞉NRA䞉NE䞉A G R䞉E䞉 䞉MS䞉 䞉E I S S䞉K䞉H䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉Q L䞉 䞉A䞉 䞉V RVB/Human-w t/CHN/WH-1/2002/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉RNCG䞉NE I S RV T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉A䞉 䞉 䞉 RVB/Human-w t/CHN/ADRV/1982/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉RNCG䞉NE I S RV T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉A䞉 䞉 䞉 RVB/Human-w t/IND/CAL/1998/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CG䞉NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/9222/2010/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NRA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/MMR/MMR-B1/2007/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/NIV-076222/2007/G3P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/IDH-084/2007/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/NIV-1048101/2010/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/IC-008/2008/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/SEN/MRC-DPRU4680/2010/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/NIV-0924341/2009/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/NIV-0948756/2009/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/BGD/Bang373/2000/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CG䞉NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/BGD/Bang117/2002/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/NIV-0632252/2006/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/NIV-957971/1995/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/NIV-005623/2000/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Human-w t/IND/NIV-04623/2004/G2P[X] 䞉 䞉 䞉D䞉L䞉 䞉 䞉 䞉E T䞉 䞉R䞉CGV NE I S R䞉T T K䞉E E䞉L D䞉 䞉 䞉 䞉KV䞉D䞉 䞉E䞉 䞉 䞉 䞉E䞉F䞉 䞉R䞉 䞉A䞉 䞉 䞉 䞉S䞉I M䞉F䞉I䞉N䞉Q䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉 䞉S䞉 䞉E I䞉N䞉D䞉H䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I L䞉V䞉 䞉 䞉 RVB/Rat-hhp/USA/IDIR/1984/G1P[X] L09722 䞉 䞉 䞉 䞉 䞉L䞉 䞉 䞉 䞉E T䞉 䞉V E CNV P䞉V A RV MNR䞉E D䞉L Y䞉 䞉 䞉 䞉R I E D䞉 䞉 䞉 䞉 䞉 䞉NE䞉L䞉 䞉R䞉 䞉S䞉 䞉 䞉S T䞉 䞉M䞉L䞉I䞉N䞉H䞉 䞉NKA䞉A E䞉A DR䞉F䞉 䞉MS䞉 䞉 䞉L S T䞉 䞉 䞉H䞉I䞉V䞉 䞉 䞉 䞉 䞉 䞉 䞉I I䞉A䞉 䞉S
* * * : . : . * : * : * * : : : : : . * * : . * * * : : * : * * : * * * : * : * * * : . * : * * * : * : * * * . * * : : * : * * * * : . * * : : . * . * : * : * : * * * * * * : : : * * * .
RVB/Cow -w t/JPN/IS-1/1999/G3P[X] I DMK L NP F P S DV V DDL I K K NS E L E NS I KV I Q - E EA NT K - - - MRY Q E E L I E E RDR I MS EMSQQ I T ML K K K I T F L RE NHK E RL E L I NQ HHE E E K K I Y K RE I S E L RL E NG T L RVB/Cow -w t/JPN/IS-2/2002/G3P[X] V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉- D䞉 䞉 䞉 䞉 䞉- - - I K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉Q䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/D-2002/2002/G3P[X] V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉- D䞉T䞉 䞉 䞉- - - I K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉Q䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/E-2002/2002/G3P[X] V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉- D䞉T䞉 䞉 䞉- - - I K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉Q䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/D-2005/2005/G3P[X] V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉- D䞉 䞉 䞉 䞉 䞉- - - I K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉Q䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/E-2005/2005/G3P[X] V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉- D䞉 䞉 䞉 䞉 䞉- - - I K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉Q䞉D䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/D-2006/2006/G3P[X] V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉- D䞉 䞉 䞉 䞉 䞉- - - I K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉Q䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/G-2006/2006/G3P[X] V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉- D䞉 䞉 䞉 䞉 䞉- - - I K䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉G䞉N䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉I䞉 䞉Q䞉D䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Cow -w t/JPN/P-2011/2011/G3P[X] V䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉K䞉 䞉 䞉 䞉 䞉 䞉A䞉 䞉-䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉R䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] S䞉F R䞉S NNH䞉 䞉 䞉I䞉 䞉 䞉 䞉 䞉R䞉D䞉 䞉T KQ䞉E E L K - CNQ I S S - - - - L E SG DF NMPY Q L QV V SA KV N䞉L S DL L KV CEG E CL K䞉Q䞉RL A䞉Q E䞉E T E D䞉I A A䞉 䞉T䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉L䞉 䞉 䞉 䞉NR䞉NT F S KGM GVB/Human-w t/CHN/WH-1/2002/G2P[X] S䞉L䞉 䞉S S䞉 䞉 䞉EA䞉A K䞉A E E䞉E KMRKQ䞉Q HL R -䞉QQ T S䞉S T T T L CEA L E SMT E R䞉K L I䞉RE K䞉T V R䞉MF L䞉CDK T NQ R䞉R䞉Q䞉Q I CE䞉EA T D䞉 䞉V䞉V䞉S䞉 䞉R䞉 䞉I L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/CHN/ADRV/1982/G2P[X] S䞉L䞉 䞉S S䞉 䞉 䞉EA䞉A K䞉A E E䞉E KMRKQ䞉E HL R -䞉QQ T S䞉S T A T L CEA L E NMT E R䞉K L I䞉RE K䞉T V R䞉MF L䞉CDK T NQ R䞉R䞉Q䞉Q I CE䞉EA T D䞉 䞉V䞉V䞉S䞉 䞉R䞉 䞉I L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/CAL/1998/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E K EQ䞉RKQ䞉 䞉HL R - DQQ T S䞉P T A I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/9222/2010/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E䞉 䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L I䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/MMR/MMR-B1/2007/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/NIV-076222/2007/G3P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/IDH-084/2007/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/NIV-1048101/2010/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKML L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/IC-008/2008/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 RVB/Human-w t/SEN/MRC-DPRU4680/2010/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/NIV-0924341/2009/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/NIV-0948756/2009/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T T I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/BGD/Bang373/2000/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉EQ䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T A I L CEA L E DMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/BGD/Bang117/2002/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉I E E䞉EQ䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T A I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉K I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/NIV-0632252/2006/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉E K䞉RKQ䞉 䞉HV R -䞉QQ T S䞉P T A I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/NIV-957971/1995/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉EQ䞉HKQ䞉 䞉HL R -䞉QQ T S䞉P T A I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/NIV-005623/2000/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉EQ䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T A I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 GVB/Human-w t/IND/NIV-04623/2004/G2P[X] S䞉L䞉 䞉 䞉S䞉 䞉 䞉EA䞉T R䞉V E E䞉EQ䞉RKQ䞉 䞉HL R -䞉QQ T S䞉P T A I L CEA L E NMT E K䞉K L V䞉RE K䞉T V NKMF L䞉C䞉R I NQ R䞉 䞉 䞉Q䞉QMCE䞉EA T D䞉 䞉A䞉V䞉S䞉 䞉R䞉 䞉T L䞉M䞉 䞉 䞉 䞉Y R䞉QM䞉 䞉V䞉 䞉 RVB/Rat-hhp/USA/IDIR/1984/G1P[X] L09722 S EV䞉 䞉S DH䞉 䞉QA䞉 䞉R䞉V䞉 䞉 䞉HA䞉T E KV A Q L E SA KQ DDNS T I I L CKA V E DMS E K L䞉KA䞉K E S S DL E K L L L䞉CNRS NS R䞉 䞉RQ L E I CE䞉E T T D䞉 䞉A A V䞉A䞉 䞉K䞉 䞉T E䞉MR䞉 䞉 䞉Y R䞉Q I V䞉A Q䞉
. : . * . * : : * : : . : : : . . : : . : : . : . . : : : . * . * . : : * : : * : : * * * * * * . * * * * . . :
RVB/Cow -w t/JPN/IS-1/1999/G3P[X] NL T I S T L NKQ F DN MS L DHMK D I QV L I E H V S DV E E RCA K L S S E NV V L RK EQ DE H I RL I KG L A DKA NL QV D I S -RVB/Cow -w t/JPN/IS-2/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 -RVB/Cow -w t/JPN/D-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 -RVB/Cow -w t/JPN/E-2002/2002/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 -RVB/Cow -w t/D-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉M - - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 -RVB/Cow -w t/JPN/E-2005/2005/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉M - - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 -RVB/Cow -w t/JPN/D-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 -RVB/Cow -w t/JPN/G-2006/2006/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 -RVB/Cow -w t/JPN/P-2011/2011/G3P[X] 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉- - - -䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 䞉 -RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X] L EY NNF䞉E T䞉HE RNV K I I SG L A A RA NL L V䞉D - - - S䞉S D䞉EA DDS K E K T E -GVB/Human-w t/CHN/WH-1/2002/G2P[X] REQ䞉DS I GQ E L䞉HS NR I V RG L A NRA G L V V䞉EV DSG NE T S D䞉S DA䞉 䞉HDDHE NS E䞉DL E DMMDPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML QMRE EME R䞉HE䞉ME I L NL NL DL D I -GVB/Human-w t/CHN/ADRV/1982/G2P[X] K EQ䞉DS I EQ E L䞉HS NR I V RG L A NRA G L V V䞉EV DSG NE T S DL S DD䞉 䞉HDDHE NS E䞉DL E DMMDPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML QMRE EME R䞉HE䞉ME I L NL NL DL D I -GVB/Human-w t/IND/CAL/1998/G2P[X] K EQ䞉DS I G䞉E L䞉HS NR I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NS E䞉DL E DMMNPG E䞉 䞉Q䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/9222/2010/G2P[X] K EQ䞉DS I G䞉E L䞉Y S NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/MMR/MMR-B1/2007/G2P[X] K EQ䞉DS I GQ E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S EQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME R䞉HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/NIV-076222/2007/G3P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S EQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/IDH-084/2007/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉I E I L NL NF DL DM -GVB/Human-w t/IND/NIV-1048101/2010/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/IC-008/2008/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -RVB/Human-w t/SEN/MRC-DPRU4680/2010/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/NIV-0924341/2009/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/NIV-0948756/2009/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NG E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/BGD/Bang373/2000/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDNHE NS E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/BGD/Bang117/2002/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDNHE NS E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/NIV-0632252/2006/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NS E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/NIV-957971/1995/G2P[X] K EQ䞉DS I G䞉E L䞉HS NR I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NS E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -GVB/Human-w t/IND/NIV-005623/2000/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NRE䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉MG I L NL NF DL DM -GVB/Human-w t/IND/NIV-04623/2004/G2P[X] K EQ䞉DS I G䞉E L䞉HS NK I I RG L A NRA G L V V䞉EV DSG NE T S DQ S DE䞉 䞉HDDHE NS E䞉DL E DMMNPG E䞉 䞉R䞉P RGG E NP RRQA䞉ML EMRE EME RF HE䞉ME I L NL NF DL DM -RVB/Rat-hhp/USA/IDIR/1984/G1P[X] L09722 䞉DRNL V䞉E E䞉HG HHL DM I RG L A A RA G L V V䞉EG DSG F E T E NS DDD䞉S E䞉 䞉DDNG - F D I E DMME PG D䞉 䞉Q RP RGG E NP RRQA䞉L RQMDNE S E䞉G DE L D䞉DDM I E PG E DE QRP RGGRNP HQA RL I QMQDE L E NMI E DL HI L DE E F DNA L F L L
. : : : : : * . . : . . * *
H1 H2 H3 H4 H5 H6
S1 S2 H7 S3 H8 H8
ᅗ3-2 BRVB㸪ࣄࢺ࠾ࡼࡧ㇜ࣟࢱ࢘ࣝࢫBࡢNSP3࣑ࣀ㓟㓄ิࡢẚ㍑
ࢻࢵࢺࡣୖẁྠࡌࡇࢆ♧ࡍ
RNA⤖ྜࢻ࣓ࣥ㸪Ș-helices (H1㹼H8)㸪ș-strands㸦S1㹼S3㸧࠾ࡼࡧ┿᰾⏕
≀ࡢ⩻ヂ㜼ᐖᅉᏊ4G⤖ྜ㡿ᇦࡣ㉥㸪㟷㸪⥳࠾ࡼࡧⲔⰍࡢᶓ⥺࡛♧ࡍ
56
110 RVB/Cow-wt/JPN/IS-1/1999/G3P[X} MAE----INESISNVLNVFETLQHETIHNVIKNTASSKLLTNCALSLLSIVTVALARNKVKLPITNKIRSNIRHIAESIVWKAETTIREIVNDVISKNDIFKDIIH RVB/Cow-wt/JPN/IS-2/2002/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/D-2002/2002/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉L䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/D-2005/2005/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/E-2005/2005/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/D-2006/2006/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/P-2011/2011/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉C䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X]䞉䞉䞉DSKMEQVIMDTLYDHI䞉䞉FAGNTT䞉䞉H䞉KDT䞉S䞉SSPQ䞉I䞉䞉GAF䞉TFGTLL䞉TIILKK䞉GINLL䞉S䞉LK䞉䞉䞉TYL䞉䞉MLAW䞉䞉䞉Q䞉䞉KD䞉TERTLQQHEVI䞉RLNT RVB/Human-wt/CHN/WH-1/2002/G2P[X]䞉䞉䞉SSDMQELFVQATYEEI䞉KLASSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GTM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉VQ䞉䞉VAYL䞉䞉ML䞉W䞉䞉NQ䞉VKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/CHN/ADRV/1982/G2P[X]䞉䞉䞉SSDMQELFVQATYEEI䞉KLASSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GTM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉VQ䞉䞉VAYL䞉䞉MV䞉W䞉䞉NQ䞉VKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/IND/NIV-04622/2004/G3P[X]䞉䞉䞉SNNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GAM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQIVKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/SEN/MRC-DPRU4680/2010/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GVM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQIVKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/IND/JBP/K/2008/G3P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GAM䞉TLGALLATLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQIVKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/MMR/MMR-B1/2007/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GAM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQIVKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/IND/NIV-094456/2009/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GAM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQIVKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/IND/IDH-084/2007/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GAM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQIVKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/IND/CAL-1/1998/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GTM䞉TLGALL䞉TLIMKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQ䞉VKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/BGD/Bang373/2000/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GTM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQ䞉VKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/BGD/Bang117/2002/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLASSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GTM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQ䞉VKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/BGD/Bang544/2001/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GTM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQ䞉VKT䞉CDE䞉LHQRKVIEKLQC RVB/Human-wt/IND/NIV-005625/2000/G2P[X]䞉䞉䞉SSNMQDLFVQATYEEI䞉KLAGSVN䞉䞉Q䞉RET䞉SSSSPQ䞉I䞉䞉GTM䞉TLGALL䞉TLIVKK䞉GTKFL䞉T䞉MQ䞉䞉IVYL䞉䞉ML䞉W䞉䞉NQ䞉VKT䞉CDE䞉LHQRKVIEKLQC RVB/Rat-hhp/USA/IDIR/1984/G1P[X]䞉䞉䞉NNEMQQLFVQAAYEEI䞉KLADSVD䞉䞉Q䞉RES䞉SNSSPQ䞉䞉䞉䞉GAL䞉TVTALF䞉TLMV䞉K䞉GTQFL䞉QKFQ䞉䞉VVHLS䞉ML䞉W䞉䞉SQ䞉VKQLCDE䞉LNQHEVLQKLQC ***::.:*:..***.:.*..::..*:**.*::::::.:.:*:*.*:.**::::*:.**::.::.::..:::: 219 RVB/Cow-wt/JPN/IS-1/1999/G3P[X} LTE---EVERIKQSISKIKGMDVTKEIFDLCEQKMRAIDDKIDDVQKSCERRIKDYDWKIAALASQNLRPVEARVNIQNQTAEVINDDEMTKNNIVRQARTKLNSKRQL RVB/Cow-wt/JPN/IS-2/2002/G3P[X]䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉I䞉䞉H䞉SV䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/D-2002/2002/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉I䞉䞉H䞉SV䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/D-2005/2005/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉I䞉䞉H䞉SV䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/E-2005/2005/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉I䞉䞉H䞉SV䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/D-2006/2006/G3P[X]䞉䞉䞉---䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉I䞉䞉H䞉SV䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉S䞉䞉䞉䞉䞉 RVB/Cow-wt/JPN/P-2011/2011/G3P[X]䞉䞉䞉---䞉䞉䞉䞉V䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉I䞉䞉H䞉SV䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉 RVB/Pig-tc/USA/LS00011_Ohio/XXXX/GXP[X]IDRILKDI䞉KM䞉YD䞉EHVA䞉L䞉䞉䞉䞉䞉L䞉SM䞉䞉䞉䞉䞉VD䞉䞉N䞉VK䞉IE䞉䞉䞉䞉䞉䞉䞉R䞉䞉䞉䞉䞉䞉S䞉䞉TLHPIQQTAVKNETVAANE䞉IKIVDEVAQ䞉TRNKPIK䞉R䞉AP䞉-R䞉 RVB/Human-wt/CHN/WH-1/2002/G2P[X]䞉DKMCSEI䞉KLRYDMEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQLP䞉HID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/CHN/ADRV/1982/G2P[X]䞉DKMCSEI䞉KLRYDMEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉䞉䞉䞉ID䞉䞉S䞉VKE䞉ER䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQLP䞉HID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/IND/NIV-04622/2004/G3P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFPTHID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/SEN/MRC-DPRU4680/2010/G2P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFP䞉HID䞉I䞉䞉HI䞉DDAENQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/IND/JBP/K/2008/G3P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFP䞉HID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/MMR/MMR-B1/2007/G2P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFP䞉HID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/IND/NIV-094456/2009/G2P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFP䞉HID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/IND/IDH-084/2007/G2P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFP䞉HID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/IND/CAL-1/1998/G2P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHTTQQFPPHID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/BGD/Bang373/2000/G2P[X]䞉DKMCLEI䞉KLRYDIERFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFPTHID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/BGD/Bang117/2002/G2P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFPTHID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/BGD/Bang544/2001/G2P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFPTHID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Human-wt/IND/NIV-005625/2000/G2P[X]䞉DKMCLEI䞉KLRYDIEHFQ䞉䞉䞉䞉䞉䞉䞉LIQM䞉䞉R䞉䞉ID䞉䞉S䞉VKE䞉E䞉䞉䞉D䞉䞉䞉R䞉䞉䞉䞉䞉䞉䞉T䞉TAHPTQQFPTHID䞉I䞉䞉HI䞉DDAETQIIQQHMNK䞉䞉䞉V䞉䞉䞉䞉RNR䞉 RVB/Rat-hhp/USA/IDIR/1984/G1P[X]䞉DQLCEDV䞉KLRYNVEHI䞉䞉L䞉ISN䞉LISLT䞉R䞉䞉AD䞉䞉GRIRDVERSCDRKIRDYDWKLAALTANPVHQIAAHVDMIS䞉HE䞉NEAEAQDIQQH䞉NK䞉䞉䞉V䞉MS䞉R-R䞉 :::*.:..:...**:::*::.::*.****.*:.:::.**:***.******:*::...*::::....:...*
Enterotoxin-like sequence of human RVB Hydrophobic region 2 (bovine RVB) (Tansmembrane region)
57
ᅗ3-4 SOSUI
ࣉࣟࢢ࣒ࣛ㸦A㸧࠾ࡼࡧ
TMHMMࣉࣟࢢ࣒ࣛ㸦B㸧ࢆ⏝࠸ࡓྛ✀
RVBᰴ
࠾ࡼࡧ
RVAᰴࡢ NSP4 ࣑ࣀ㓟㓄ิࢆ⏝࠸ࡓぶỈᛶ/Ỉᛶࣉࣟࣇࣝ࠾ࡼࡧ⭷㈏㏻㡿
ᇦࡢ᥎ᐃ
58
⾲4-1
VP3
䛻䛚䛡䜛ሷᇶ㓄ิ䠄ୗ䠅䛚䜘䜃䜰䝭䝜㓟㓄ิ䠄ୖ䠅䛾┦ྠᛶ䠄䠂䠅
94.0-100 73.0
97.5-99.5 70.0
95.0-100 92.1-100
⾲4-2
NSP3䛻䛚䛡䜛ሷᇶ㓄ิ䠄ୗ䠅䛚䜘䜃䜰䝭䝜㓟㓄ิ䠄ୖ䠅䛾┦ྠᛶ䠄䠂䠅
92.3-100 74.0
92.8-99.8 78.0
96.2-100 96.1-100
⾲
4-3NSP4䛻䛚䛡䜛ሷᇶ㓄ิ䠄ୗ䠅䛚䜘䜃䜰䝭䝜㓟㓄ิ䠄ୖ䠅䛾┦ྠᛶ䠄䠂䠅
93.6-100 69.0
90.5-99.8 70.0
96.8-100 96.5-100
䡲䡫䢀䡱䢈್
(%)
M4 68.8 68.7-69.0 63.3-63.9
M1 72.6-72.9 60.9-62.0 71.0
M2 68.3-68.9 61.6-63.0 72.0-72.3
M1 (
䝷䝑䝖
) M2 (䝠䝖
) M3 (∵
) M4 (㇜
)E3 52.6-53.0 53.8-56.1 38.4-38.8
E2 68.6-69.7 37.9-39.3 55.7-57.5
M2 (䝠䝖) M3 (∵) M4 (㇜)
M3 63.7-63.8 63.9-64.9
T3
70.8 68.7-69.7
E4 61.4 63.9-65.6
䡲䡫䢀䡱䢈್
(%)
E1 65.8-67.1 36.1-37.4 47.5
M1 (䝷䝑䝖)
䡲䡫䢀䡱䢈್
M1 (䝷䝑䝖) M2 (䝠䝖) M3 (∵) M4 (㇜) (%)
59.7-61.3 57.7-60.3
70.3-72.3 56.4-56.9 62.3
61.2-62.1
57.9-58.2
55.3-56.2 T1
T2
T4 65.9-66.4
67.4-67.9 66.9-68.2 76.0-76.5
⾲
3-3⾲
3-4⾲
3-259
㸦㸣㸧
㸦㸣㸧
ᅗ3-5 VP3ࡢሷᇶ㓄ิ(A)࠾ࡼࡧ࣑ࣀ㓟㓄ิ(B)࠾ࡅࡿ┦ྠᛶศᕸᅗ
㸦┦ྠᛶ㢖ᗘ㸦㸣㸧 㸧
㸦┦ྠᛶ㢖ᗘ㸦㸣㸧 㸧
VP3
ሷᇶࣞ࣋ࣝࡢ࢝ࢵࢺ࢜ࣇ್㸸70㸣
VP3
࣑ࣀ㓟ࣞ࣋ࣝࡢ࢝ࢵࢺ࢜ࣇ್㸸73㸣
60
㸦㸣㸧
㸦㸣㸧
ᅗ3-6 NSP3ࡢሷᇶ㓄ิ(A)࠾ࡼࡧ࣑ࣀ㓟㓄ิ(B)࠾ࡅࡿ┦ྠᛶศᕸᅗ
㸦┦ྠᛶ㢖ᗘ㸦㸣㸧 㸧
㸦┦ྠᛶ㢖ᗘ㸦㸣㸧 㸧
61
ᅗ3-7 NSP4ࡢሷᇶ㓄ิ(A)࠾ࡼࡧ࣑ࣀ㓟㓄ิ(B)࠾ࡅࡿ┦ྠᛶศᕸᅗ
㸦㸣㸧
㸦㸣㸧 㸦 ┦ ྠ ᛶ 㢖 ᗘ 㸦 㸣 㸧㸧
㸦 ┦ ྠ ᛶ 㢖 ᗘ 㸦 㸣 㸧㸧
62
ᅗ3-8 VP3 (a)㸪NSP3 (b)࠾ࡼࡧNSP4 (c)࠾ࡅࡿ࣑ࣀ㓟ᇶ࡙ࡃศᏊ⣔⤫ᶞ
ࣈ࣮ࢶࢫࢺࣛࢵࣉ್ࡣྛࢢ࣮ࣝࣉࡢศᒱ♧ࡍ
ࣟࢱ࢘ࣝࢫBࡢ㑇ఏᏊᆺࢆྑഃ♧ࡍ ᮏ❶࡛ゎᯒࢆ⾜ࡗࡓᰴࢆە࡛♧ࡍ
63 ᅗ3-8 㸦⥆ࡁ㸧
64
ᅗ3-9. VP7 (A)㸪VP4 (B)㸪VP6 (C)㸪VP1 (D)㸪VP2 (E)㸪NSP1 (F)㸪NSP2 (G)
࠾ࡼࡧNSP5 (H)࠾ࡅࡿ࣑ࣀ㓟ᇶ࡙ࡃศᏊ⣔⤫ᶞ
ࣈ࣮ࢶࢫࢺࣛࢵࣉ್ࡣྛࢢ࣮ࣝࣉࡢศᒱ♧ࡍ
ࣟࢱ࢘ࣝࢫBࡢ㑇ఏᏊᆺࢆྑഃ♧ࡍ ᮏ❶࡛ゎᯒࢆ⾜ࡗࡓᰴࢆە࡛♧ࡍ
65
⾲
3-5䚷
VP7䛾ሷᇶ㓄ิ䠄 ୗ䠅 䛚 䜘 䜃 䜰 䝭 䝜 㓟䠄 ୖ䠅 䛻 䛚 䛡 䜛 ┦ྠᛶ
G1 (䝷䝑 䝖
)G2 (䝠䝖
)G3 (∵䚷᪥ᮏ䞉 䜰䝯 䝸 䜹
)G4 (㇜
)G5 (∵䚷 䜲 䞁 䝗
)G6 (㇜
)G7 (㇜
)G8 (㇜
) G149.2-50.450.0-51.750.051.352.552.551.2 G256.9-57.359.5-63.260.7-61.661.6-62.863.2-63.664.1-64.563.2 G357.8-59.760.3-62.558.3-61.285.0-88.866.9-68.669.0-71.965.3-67.8 G455.761.4-62.861.6-64.360.763.662.059.5 G557.1-57.263.8-64.377.1-78.964.9-65.268.672.3-72.768.2 G658.165.2-65.866.0-68.263.468.5-68.6 G758.563.9-64.764.5-68.263.467.9-68.0 64.3-66.066.7-68.962.368.9-69.071.570.7 69.369.8 67.668.5G858.8
66
⾲ 3- 6 䚷 VP4 䛾ሷᇶ㓄ิ䠄 ୗ䠅 䛚 䜘 䜃 䜰 䝭 䝜 㓟䠄 ୖ䠅 䛻 䛚 䛡 䜛 ┦ྠᛶ 61. 0- 63. 7 61. 5- 64. 6 64. 7- 69. 1 64. 3- 68. 4
64. 7- 73. 3 ㇜
∵䠄 䜲 䞁 䝗 䠅 63. 1- 62. 7 63. 0- 64. 0 80. 1- 82. 0
64. 7- 65. 4 64. 0- 64. 8 90. 0- 91. 7 65. 2- 74. 0
60. 7- 65. 0 ∵䠄 ᪥ᮏ䠅
䝠䝖 63. 6- 64. 2 64. 5- 66. 0 63. 3- 64. 8
䝷䝑 䝖 64. 5- 65. 5 67. 4- 67. 6 65. 7- 66. 7 60. 0- 62. 9
∵䠄 ᪥ᮏ䠅 ∵䠄 䜲 䞁 䝗 䠅 ㇜ 䝷䝑 䝖 䝠 䝖
67
⾲ 㻟 㻙㻣䚷 㼂 㻼 㻢䛾 ሷ ᇶ 㓄 ิ 䠄ୗ 䠅䛚 䜘 䜃 䜰 䝭 䝜 㓟 䠄ୖ 䠅䛻 䛚 䛡 䜛 ┦ ྠ ᛶ I4 69. 1- 69. 8 71. 4- 74. 1 73. 5- 74. 9 73. 8- 76. 2
I3 ( 䜲䞁 䝗 ) 70. 4- 73. 8 69. 8- 71. 2 78. 8- 81. 0 86. 5- 88. 9
I3 ( ᪥ᮏ ) 69. 6- 71. 7 68. 8- 71. 4 92. 1- 95. 2 85. 7- 87. 3
I2 74. 3- 74. 9 82. 5- 85. 7 82. 5- 86. 5 79. 4- 82. 5
I1 89. 7- 92. 1 85. 7- 86. 5 86. 5- 88. 1 81. 8
I1 ( 䝷䝑 䝖 ) I2 ( 䝠䝖 ) I3 ( ᪥ᮏ䚷 ∵ ) I3 ( ∵䚷 䜲 䞁 䝗 ) I4 䠄㇜ 䠅
68
⾲㻟 㻙 㻤 䚷 㼂 㻼 㻝 ሷ ᇶ㓄ิ䠄 ୗ䠅 䛚 䜘 䜃 䜰 䝭 䝜 㓟䠄 ୖ䠅 䛻 䛚 䛡 䜛 ┦ྠᛶ 62. 2- 66. 5 61. 1- 70. 0 62. 8- 71. 0 65. 2- 74. 2
62. 4- 63. 1 65. 4- 66. 9 74. 2- 76. 6 69. 1- 86. 0 ㇜
60. 9- 61. 8 65. 2- 67. 6 85. 4- 87. 6 67. 4- 82. 6 ∵䠄 䜲 䞁 䝗 䠅 67. 2- 68. 5 68. 0- 70. 8 66. 9- 69. 7 69. 1- 75. 8 ∵䠄 ᪥ᮏ䠅
75. 3- 76. 4 65. 7- 68. 0 66. 9- 68. 0 69. 1- 76. 4 䝠䝖
䝷䝑 䝖
䝷䝑 䝖 䝠 䝖 ∵䠄 ᪥ᮏ䠅 ∵䠄 䜲 䞁 䝗 䠅 ㇜
69
⾲ 㻟 㻙㻥䚷 㼂 㻼 㻞䛾 ሷ ᇶ 㓄 ิ 䠄ୗ 䠅䛚 䜘 䜃 䜰 䝭 䝜 㓟 䠄ୖ 䠅䛻 䛚 䛡 䜛 ┦ ྠ ᛶ ㇜ 69. 5- 73. 7 69. 5- 74. 6 69. 5- 78. 1 69. 0- 77. 8
∵䠄 䜲 䞁 䝗 䠅 71. 5- 72. 0 68. 8- 71. 0 80. 5- 82. 0 72. 8- 92. 7
∵䠄 ᪥ᮏ䠅 70. 2- 70. 7 68. 8- 72. 0 94. 9- 97. 1 74. 3- 91. 2
䝠䝖 77. 3- 78. 5 75. 0- 76. 5 75. 7- 77. 2 71. 3- 86. 8
䝷䝑 䝖 90. 4- 91. 2 75 .7 76 .5 73. 5- 84. 6
䝷䝑 䝖 䝠 䝖 ∵䠄 ᪥ᮏ䠅 ∵䠄 䜲 䞁 䝗 䠅 ㇜
70
⾲ 㻟㻙㻝㻜䚷 㻺 㻿 㻼 㻝 㻌䝨 䝥 䝏 䝗 㻙㻞 䛾ሷᇶ㓄ิ䠄 ୗ䠅 䛚 䜘 䜃 䜰 䝭 䝜 㓟䠄 ୖ䠅 䛻 䛚 䛡 䜛 ┦ྠᛶ
70.8-77.3 A753.1-53.551.8-55.458.1-58.759.8-60.959.6-61.567.6-69.070.8-72.473.970.8-72.7 A653.453.5-54.562.260.1-61.060.9-61.369.7
70.0-70.859.0-59.356.2-56.555.6-56.8 A554.051.4-52.361.061.0-60.661.8-62.2 52.5-54.4 A452.2-52.652.3-52.967.5-68.2
51.9-52.451.1-52.168.6-69.270.5-72.856.8-57.554.4-55.3 66.5-67.156.554.451.2-51.9 A3 (
᪥ᮏ
) 43.3-45.2 A3 (䝠䝒 䝆
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A5 (
㇜
)A6 (㇜
)A7 (㇜
) A163.2-63.6A1 (
䝷䝑 䝖
)A2 (䝠䝖
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)A3 (∵䚷 ᪥ᮏ
)A4 (∵䚷 䜲 䞁 䝗
)71
⾲ 㻟㻙㻝㻝䚷 㻺 㻿 㻼 㻞 䛾ሷᇶ㓄ิ䠄 ୗ䠅 䛚 䜘 䜃 䜰 䝭 䝜 㓟䠄 ୖ䠅 䛻 䛚 䛡 䜛 ┦ྠᛶ N4 70. 2- 73. 3 68. 3- 71. 2 65. 6- 68. 0 67. 6- 70. 4 64. 9- 66. 4
N365.6-67.674.8-76.073.373.8-74.3
69. 6- 70. 3
N2 (
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N2 (
䜲䞁 䝗
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N2 (
∵䚷 ᪥ᮏ
)65.4-69.089.1-92.086.2-89.179.7-81.971. 7- 74. 6
N167.4-73.268.1-73.267.4-73.967.4-69.6
71. 7- 81. 9
N4 (
㇜
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)N2 (∵䚷 ᪥ᮏ
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)N2 (㇜
)N3 (㇜
)72
⾲ 㻟 㻙㻝㻞䚷 㻺 㻿 㻼 㻡 䛾 ሷ ᇶ 㓄 ิ 䠄 ୗ 䠅 䛚 䜘 䜃 䜰 䝭 䝜 㓟 䠄 ୖ 䠅 䛻 䛚 䛡 䜛 ┦ ྠ ᛶ
82.0-83.2 H6 (䝠䝒 䝆
)47.946.1-47.147.5-47.948.5-49.668.9-71.078.4-79.676.9-77.385.6-88.682.0-83.2 H6 (
∵䚷 䜲 䞁 䝗
)50.6-51.348.8-51.848.7-49.648.1-50.268.9-73.476.3-79.050.0-50.648.2-49.950.4-51.548.5-51.167.7-72.6
70.8-73.270.2-70.8 H6 (
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H365.3-68.063.6-66.165.1-66.541.1-44.642.9-44.0 58.9-62.954.9-58.941.1-43.443.4-44.643.4-45.140.0-40.6
45.7-46.342.3 H268.0-68.8
H165.7-68.062.3-64.662.9-63.644.0-45.743.4-44.0 H5 (
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)H1 (䝷䝑 䝖
)H2 (䝠䝖
)H3 (㇜
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)73
⥲ ᣓ
BRVB ࡣ㸪ᡃࡀᅜ࡛ࡣ BCoVḟࡄᡂ∵ࡢୗ⑩ࡢཎᅉࡉࢀ࡞ࡀࡽࡶ㸪࢘
ࣝࢫᏛⓗ࡞▱ぢࡣ༑ศሗ࿌ࡉࢀ࡚࡞ࡗࡓࠋࡑࡇ࡛ᮏ◊✲࡛ࡣ㸪BRVB ࡢ 㜵㈨ࡍࡿࡓࡵ㸪ࡇࢀࡲ࡛▱ࡽࢀ࡚࠸࡞ࡗࡓBRVB ࡢᏛ࠾ࡼࡧศᏊ⏕≀
Ꮫⓗᛶ≧ࡘ࠸࡚◊✲ࢆᐇࡋࡓࠋ
➨୍❶࡛ࡣ BRVBࡢᡂ∵ࡢឤᰁࡼࡾ㸪ୗ⑩≧௨እࡶἪங㔞పୗࢆᘬ ࡁ㉳ࡇࡍࡇࢆୡ⏺࡛ึࡵ࡚᫂ࡽࡋࡓࠋࡉࡽ㸪᳨ฟ࢘ࣝࢫࡢ㑇ఏᏊゎ
ᯒ࡛ࡣ, RNA-PAGEࡽࢩ࣮ࣙࢺࢤࣀ࣒ࣃࢱ࣮ࣥࢆ♧ࡍࡇࡀุ᫂ࡋ㸪ᡃࡀᅜ
᭱ึࡢBRVBᰴ࡛࠶ࡿ Nemuroᰴࡢࣟࣥࢢࢤࣀ࣒ࣃࢱ࣮ࣥ␗࡞ࡿࡇࡽ㸪
ᡃࡀᅜࡣᑡ࡞ࡃࡶ᪉ࡢᰴࡀᏑᅾࡋ࡚࠸ࡿࡇࢆ᫂ࡽࡋࡓࠋ
➨❶࡛ࡣ㸪つᶍ㓗㎰ᆅᖏ࠾࠸࡚㸪3ᖺ㛫㝸࡛2ᅇࡢBRVBࡼࡿ㞟ᅋ ᛶୗ⑩ࡀⓎ⏕ࡋࡓࡼࡾ㸪BRVBࡼࡿୗ⑩ࡢⓎ⏕ࡣ∵⩌ࡢචࣞ࣋ࣝᙳ 㡪ࡉࢀ㸪ྠࡌ㎰ሙෆ࠾࠸࡚ࡶ∵⩌ࡢᢠయࣞ࣋ࣝࡀపୗࡍࡿឤᰁࡀ㉳ࡇࡾ㸪 㞟ᅋᛶࡢୗ⑩ࢆ⧞ࡾ㏉ࡍࡇࢆ᫂ࡽࡋࡓࠋࡲࡓಶయ࡛ࣞ࣋ࣝࡣ㸪BRVB ࡣឤᰁࡍࡿࡀ㸪ឤᰁ࡛ࡣࡉ㔜⠜࡞≧ࢆ♧ࡉ࡞࠸ࡇࢆ᫂ࡽࡋࡓࠋ
➨୕❶࡛ࡣ㸪ࡇࢀࡲ࡛▼ᕝ┴᳨࡛ฟࡉࢀࡓBRVB 9ᰴࡢ㑇ఏᏊ㓄ิࢆỴ ᐃࡋ㸪VP3㸪NSP4࠾ࡼࡧNSP5ࡀࡢࣟࢱ࢘ࣝࢫ Bࡢ㑇ఏᏊ㓄ิࡣ࡞
ࡾ␗࡞ࡾ㸪᪂ࡋ࠸㑇ఏᏊᆺ࡛࠶ࡿࡇࢆぢ࠸ࡔࡋࡓࠋࡲࡓᡃࡀᅜ࠾ࡼࡧࣥࢻ ࡢBRVBࡣ࡚ࡢ㑇ఏᏊࢭࢢ࣓ࣥࢺ࠾࠸࡚ࡢࣟࢱ࢘ࣝࢫBࡣ␗࡞ࡗࡓ ࢢ࣮ࣝࣉࢆᙧᡂࡍࡿࡇࡀุ᫂ࡋ㸪RVB ࢆศᏊ⏕≀Ꮫⓗゎ᫂ࡍࡿୖ࡛᭷⏝࡞
ሗࢆᚓࡿࡇࡀ࡛ࡁࡓࠋ
ᮏ◊✲࡛ࡣ㸪BRVB ࡢឤᰁࢆ㏻ࡋ㸪ヲ⣽࡞ᏛㄪᰝศᏊ⏕≀Ꮫⓗゎᯒ
ࢆ⾜࠺ࡇࡼࡾ㸪᪂ࡓ࡞▱ぢࡀᩘከࡃᚓࡽࢀࡓඹ㸪⩌චࡢ㔜せᛶࡀ᫂
ࡽ࡞ࡗࡓࠋ
74
ᑗ᮶ⓗࡣBRVBᑐࡍࡿ࣡ࢡࢳࣥ㛤Ⓨࡀ࡞ࡉࢀ㸪BRVBࡼࡿ⤒῭ⓗ⿕ᐖ ࡀ᭱ᑠ㝈ࡵࡽࢀࡿࡼ࠺࡞ࡿࡇࢆᮇᚅࡋࡓ࠸ࠋ
75 ㅰ ㎡
ᮏㄽᩥసᡂ࠶ࡓࡾࠊᩘከࡃࡢࡈᣦᑟࡈຓゝࢆ㈷ࡾࡲࡋࡓ㸪ᮾி㎰ᕤᏛ
㎰Ꮫ㒊㝃ᒓᅜ㝿ᐙ␆ឤᰁ㜵◊✲ᩍ⫱ࢭࣥࢱ࣮ Ỉ㇂ဴஓᩍᤵ࡞ࡽࡧ▼ᕝ
┴❧Ꮫ⏕≀㈨※⎔ቃᏛ㒊⏕⏘⛉Ꮫ⛉ື≀⦾ṪᏛ◊✲ᐊ 㛗ㄔᩍᤵ㸪ࡲࡓ◊
✲ࡢ㐙⾜㝿ࡋ㸪㛗ᖺࢃࡓࡾࡈᣦᑟࡈຓゝࢆ㈷ࡾࡲࡋࡓඖ㎰ᴗ࣭㣗ရ⏘ᴗᢏ
⾡⥲ྜ◊✲ᶵᵓ ື≀⾨⏕◊✲㒊㛛 ᾏ㐨◊✲ᣐⅬ㛗 ᜏග⿱ඛ⏕῝ࡃᚚ
♩⏦ࡋୖࡆࡲࡍࠋ
ࡲࡓᮏㄽᩥⲡ✏࠶ࡓࡾ㸪᭷┈࡞ࡈຓゝࡈᰯ㜀ࢆ㈷ࡾࡲࡋࡓ㸪ᖏᗈ␆⏘
Ꮫᛂ⏝⋇་Ꮫ⣔ ᑠᕝᬕᏊᩍᤵ㸪ᒾᡭᏛᐇ㦂ື≀Ꮫ◊✲ᐊ ྂᕷ㐩ဢᩍᤵࠊ ᮾி㎰ᕤᏛ㎰Ꮫ㒊ඹྠ⋇་Ꮫ⛉⋇་ఏᰁᏛ◊✲ᐊ ⓑ῟㈨ᩍᤵࠊᒱ㜧
Ꮫே⋇ඹ㏻ឤᰁᏛ◊✲ᐊ ఀ⸨┤ேᩍᤵᚰࡼࡾឤㅰ⏦ࡋୖࡆࡲࡍࠋ
ࡲࡓᮏ◊✲ከ࡞ࡿࡈ⌮ゎࡈᨭࢆ㈷ࡾࡲࡋࡓ▼ᕝ┴㎰ᯘỈ⏘⥲ྜࢭࣥ
ࢱ࣮␆⏘ヨ㦂ሙ ᆏཱྀᨻಙሙ㛗㸪᪩ᕝ⿱ሙ㛗㸪ᅵᒇ࠸࡙ࡳᢏ⾡㛤Ⓨ㒊㛗㸪
ඖ㤶⳯Ꮚ௵ᢏᖌࡉࡽ᳨ᰝᮦᩱࡢ᥇ྲྀࡈ༠ຊ࠸ࡓࡔ࠸ࡓ▼ᕝ┴ෆࡢ㎰ᐙ ࡢⓙᵝឤㅰ࠸ࡓࡋࡲࡍࠋ
᭱ᚋᮏㄽᩥࡢసᡂ࠶ࡓࡾ㸪ẕぶᴗࢆ௦⾜ࡋ࡚ࡃࢀࡓኵᛂࡋ࡚ࡃࢀࡓ ឡፉឤㅰࡢពࢆ♧ࡋ㸪ㅰ㎡ࡉࡏ࡚࠸ࡓࡔࡁࡲࡍࠋ
76 ཧ⪃ᩥ⊩
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