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125

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127

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Acknowledgements

I am deeply indebted to Professor Hidetoshi Sato (Kwansei-Gakuin University) for his guidance, supports of apparatus and knowledge.

I'd like to express my utmost gratitude to Professor Yukihiro Ozaki (Kwansei-Gakuin University) for his continuous instructions, encouragements and

emotional supports throughout this study.

I am eternallygratefu1 to Professor Takashi Katagiri(Tohoku University) and Professor Yuji Matsuura (Tohoku University), for his precious coaching to fabricate ball-lens mounted hollow-fiber Raman probes, and for his cooperation to provide hollow optical fibers, respectively. I express my best appreciation for Dr. Tamitake Ito (AIST) for his valuable comments and discussions in the course of Chapter 1. I also thank Dr. Yusuke Oshima (NIBB) for his teaching to setup a Raman system in Chapter 3.The authoralso

thanksDr. Hideyuki Shinzawa (AIST), Dr. Shin-ichiMorita (RIKEN), and Mr. Atsushi

Maruyama (Nagaoka University of Technology), for their fruitfu1 comments and discussions in Chapter 4, Chapterl and Chapter 5, respectively.

I also give special thanks to Dr. Harumi Sato (Kwansei-Gakuin University) for her valuable discussions and heartfelt comments in the course of my Ph. D work.I appreciate Ms.

Ayumi Kimura, Mr. Satoshi Nomura, Mr. Shin Tachibana and Ms.YoshikoShimomura for

their technical supports in this study. I also give thanks to Dr. Toshiaki Suzuki for his

continuous help among the same laboratories. I am gratefu1 to all members in Sato Optical biopsy in RIKEN and collaborators, especially to Mr. Tokuji Kitsunai, Mr. Yuichi Komachi, Dr. Bibin B. Andriana, Dr. Yuzo Ishida, Dr. Satoshi Wada, Dr. Norihito Saito, Dr. Takayo Ogawa and Dr. Urata Yoshiharu for their encouragements for my Ph. D study. I am also

129

gratefu1 to all members in Ozaki laboratory and Sato laboratory in KwanseiGakuin

University, especially to Mr. Ken Nakamura and Mr. Yuhei Tanaka, for their emotional asslstance.

Moreover, I give special thanks to my family for their financial supports and fancy encouragements.

This study is supported by SENTAN, Japan Science and Technology Agency (JST) and by DC2 from Japan Society for the Promotion of Science (JSPS).

List of Publications

Papers

Original Papers:

(1) Yuko S. Yamamoto, Yusuke Oshima, Hideyuki Shinzawa, Takashi Katagiri, Yuji Matsuura, Yukihiro Ozaki, and Hidetoshi Sato,"Subsurface Sensing ofBiomedical Tissues Using a Miniaturized Raman Probe: Study ofThin-layered Model Samples"

AnalyticaChimicat4cta, Elsevier, 619, 8 (2008)

(2) TakashiKatagiri, Yuko S. Yamamoto, Yukihiro Ozaki, Yuji Matsuuraand Hidetoshi Sato"High axial resolution Raman probe made of single hollow optical fiber"

Appl.Spectrosc.,63, 103(2009)

(3) Hidetoshi Sato, Yuko S. Yamamoto,Atsushi Maruyama, TakashiKatagiri, Yuji Matsuura, and Yukihiro Ozaki,"Raman study ofbrain functions in live mice and rats: A pilot

study"

vab. Spectrosc.,50, 125 (2009)

(4) Yuko S. Yamamoto, Hideyuki Shinzawa, Yuji Matsuura, Yukihiro Ozaki, and Hidetoshi Sato, "Noninvasive Subsurface Analysis Using Multiple Miniaturized Raman Probes, Part I: Basic Study ofThin-Layered Transparent Models ofBiomedical Tissues"

ApLpl. Spectrosc,65, 34 (201 1).

(5) Yuko S. Yamamoto, Hidetoshi Sato, and Yukihiro Ozaki, "Basic Study ofSubsurface Probing through Diffusely Scattering Media Using Raman Microscope"

To be submitted.

131

Proceedings:

(1) Yuko S. Yamamoto, Yuichi Komachi, Hideyuki Shinzawa, Atsushi Maruyama, Bibin B.

Andriana, Yuji Matsuura, Yukihiro Ozaki, and Hidetoshi Sato, "Noninvasive subsurface analyzing technique using multiple miniaturized Raman probes"

Proceedings ofSPIE, 7173-27(2009)

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"Subsurface Sensing ofBiomedical Tissues Using a Miniaturized Raman Probe: Study

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TOIN International Symposium on Biomedical Engineering 2008, BE24, 2008 tEIi 10 A

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"Noninvasive subsurface sensing using multiple miniaturized Raman probes: evaluation

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Awards:

(1) Best Poster Award

Yuko S. Yamamoto, Yusuke Oshima, Shin-ichi Morita, Yukihiro Ozaki, Hidetoshi Sato "Subsurface Sensing ofBiomedical Tissues Using a Miniaturized Raman Probe: Study

ofThin-Layered Model Samples"

The 9th Asian Conference on Analytical Sciences (Asianalysis XI), Jeju island, Jeju city,

Korea, Nov 2007

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135

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