稿を終えるにあたり、御懇篤なる御指導を頂きました九州⼤学⼤学院⻭学研究院⼝腔顎 顔⾯病態学講座顎顔⾯腫瘍制御学分野の中村誠司教授に深甚なる謝意を表します。
また、直接御指導頂きました森⼭雅⽂助教に深謝致します。さらに、常に励ましの⾔葉 を頂きました同分野の皆様に深く感謝致します。
最後に、蔭ながら⽀えてくれた同分野や⼤学の同期、そして家族に感謝致します。
参考文献
1. Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. New Engl J Med. 2001;344(10):732-8.
2. Takano K, Yamamoto M, Takahashi H, et al. Clinicopathologic similarities between Mikulicz disease and Kuttner tumor. Am J Otolaryngol. 2010;31(6):429-34.
3. Morgan WS, Castleman B. A clinicopathologic study of Mikulicz's disease. Am J Pathol.
1953;29(3):471-503.
4. Yamamoto M, Takahashi H, Sugai S, et al. Clinical and pathological characteristics of Mikulicz's disease. Autoimmun Rev. 2005;4(4):195-200.
5. Maehara T, Moriyama M, Nakashima H, et al. Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. Ann Rheum Dis. 2012;71(12):2011-9.
6. Umehara H, Okazaki K, Masaki Y, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol. 2012;22(1):21-30.
7. Moriyama M, Furukawa S, Kawano S, et al. The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease. Int J Oral Maxillofac Surg. 2014;43(10):1276–81.
8. Moriyama M, Ohta M, Furukawa S, et al. The diagnostic utility of labial salivary gland biopsy in IgG4-related disease. Mod Rheumatol. 2016;26(5):725-9.
9. Fujibayashi T, Sugai S, Miyasaka N, et al. Revised Japanese criteria for Sjogren's syndrome (1999): availability and validity. Mod Rheumatol. 2004;14(6):425-34.
10. Fox RI. Sjogren's syndrome. Lancet. 2001;366(9482):321-31.
11. Price EJ, Venables PJ. The etiopathogenesis of Sjogren's syndrome. Semin Arthritis Rheum.
1995;25(2):117-33.
12. Kennedy MK, Torrance DS, Picha KS, et al. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol. 1992;149(7):2496-505.
13. Rapoport MJ, Jaramillo A, Zipris D, et al. Interleukin 4 reverses T cell proliferative
unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med.
1993;178(1):87-99.
14. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, et al. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8(9):942-9.
15. Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I.
Definition according to profiles of lymphokine activities and secreted proteins. J Immunol.
1986;136(7):2348-57
16. Kennedy MK, Torrance DS, Picha KS, et al. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol. 1992;149(7):2496-505.
17. Rapoport MJ, Jaramillo A, Zipris D, et al. Interleukin 4 reverses T cell proliferative
unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med.
1993;178(1):87-99.
18. Afzali B, Lombardi G, Lechler RI, et al. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol.
2007;148(1):32-46.
19. Infante-Duarte C, Horton HF, Byrne MC, et al. Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol. 2000;165(11):6107-15.
20. Ziolkowska M, Koc A, Luszczykiewicz G, et al. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol. 2000;164(5):2832-8.
21. Moriyama M, Tanaka A, Maehara T, et al. T helper subsets in Sjögren’s syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review. J Autoimmun. 2014;51:81-8.
22. Theander E, Vasaitis L, Beacklund E, et al. Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome. Ann.Rheum.Dis. 2011;70(8):1363-8.
23. Lyn-Cook B, Xie C, Oates J, et al. Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: ethnic differences and potential new targets for therapeutic drugs. Mol Immunol. 2014;61(1):38-43.
24. Broen JC, Bossini-Castillo L, van Bon L, et al. A rare polymorphism in the gene for toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators. Arthritis Rheum. 2012;64(1):264–71.
25. Barrat FJ, Meeker T, Gregorio J, et al. Nucleic acids of mammalian origin can act as
endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus. J Exp Med. 2005;202(8):1131–9.
26. Greenspan JS, Daniels TE, Talal N, et al. The histopathology of Sjögren’s syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974;37(2):217-29.
27. Bolstad BM, Irizarry RA, Astrand M, et al. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 2003;19(2):185-93.
28. Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5(10):R80.
29. Gordon KS. Limma: linear models for microarray data. Bioinformatics and Computational Biology Solutions using R and Bioconductor 2005;397-420.
30. van der Neut Kolfschoten M, Schuurman J, Losen M, et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science. 2007;317(5844):1554-7.
31. Schuurman J, Van Ree R, Perdok GJ, et al. Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites. Immunol. 1999;97(4):693-8
32. Rispens T, Ooievaar-De Heer P, Vermeulen E, et al. Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions. J Immunol. 2009;182(7):4275-81 33. Liu C, Zhang H, Yao G, et al. Characteristics of primary Sjögren's syndrome patients with IgG4
positive plasma cells infiltration in the labial salivary glands. Clin Rheumatol. 2017;36(1):83-8.
34. Sato Y, Takata K, Ichimura K, et al. IgG4-producing marginal zone B-cell lymphoma. Int J Hematol. 2008;88(4):428-33.
35. Ohta M, Moriyama M, Goto Y, et al. A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis. World J Surg Oncol. 2015;13:67.
36. Abe T, Maruyama S, Babkair H, et al. Simultaneous immunolocalization of desmoglein 3 and IgG4 in oral pemphigus vulgaris: IgG4predominant autoantibodies in its pathogenesis. J Oral Pathol Med. 2015;44(10):850-6.
37. Chen LF, Mo YQ, Ma JD, et al. Elevated serum IgG4 defines specific clinical phenotype of rheumatoid arthritis. Mediators Inflamm. 2014;2014:635293.
38. J Gill, N Angelo, ML Yeong, et al. Salivary duct carcinoma arising in IgG4-related autoimmune disease of the parotid gland. Hum Pathol. 2009;40 (6):881-6.
39. Takano K, Okuni T, Kamekura R, et al. Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. Mod Rheumatol. 2018;29(2):393-6.
40. Shimizu M, Okamura K, Kise Y, et al. Effectiveness of imaging modalities for screening IgG4-related dacryoadenitis and sialadenitis (Mikulicz's disease) and for differentiating it from Sjögren's syndrome (SS), with an emphasis on sonography. Arthritis Res Ther. 2015;17:223.
41. Takano K, Yajima R, Kamekura R, et al. Clinical Utility of 18F-Fluorodeoxyglucose/Positron Emission Tomography in Diagnosis of Immunoglobulin G4–Related Sclerosing Sialadenitis.
Laryngoscope. 2018;128(5) 128:1120–5.
42. Kassan SS, Moutsopoulos HM, et al. Clinical manifestations and early diagnosis of Sjogren syndrome. Arch Intern Med. 2004;164 (12):1275-84.
43. Ishimaru N, Saegusa K, Yanagi K, et al. Estrogen Deficiency Accelerates Autoimmune Exocrinopathy in Murine Sjo ̈gren’s Syndrome through Fas-Mediated Apoptosis. Am J Pathol. 1999;155(1):173-81.