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５ 平成１６年度中に発表されたアイソトープ 総合施設利用者の研究成果
論文（英文） ７６編 論文（和文） ２５編 学会発表（国際学会） ３２編 学会発表（国内学会） １１８編
論文（英文）
1. Furukawa K, Hori M, Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Miyazaki A, Nakayama H, Horiuchi. S. Adiponectin down-regulates acyl-coenzyme A:choresterol acyltransferase-1 (ACAT-1) in cultured human monocyte-derived macrophages.
Biochem Biophys Res Commun. 317, 831-836(2004).
2. Hori M, Satoh M, Furukawa K, Sakamoto Y, Hakamata H, Komohara Y, Takeya M, Sasaki Y, Miyazaki A, Horiuchi S. Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats.
Arterioscler Thromb Vasc Biol. 24, 1689-1695(2004).
3. Unno Y, Sakai M, Sakamoto Y, Kuniyasu A, Nakayama H, Nagai R, Horiuchi S. Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36. Biochem Biophys Res Commun. 325, 151-156(2004).
4. Nagai R, Accumulation of Advanced Glycation End Products in Age-dependent Disorders. Med. Hypotheses Res. 1, 159-168(2004).
5. Fukuhara-Takaki K, Sakai M, Sakamoto Y, Takeya M, Horiuchi S.
Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes. J Biol Chem. 280, 3355-3364(2005).
6. Sakamotoa Y, Miyazaki A, Tamagawa H, Wanga G, Horiuchi S.
Specific interaction of oxidized low-density lipoprotein with thrombospondin-1 inhibits transforming growth factor-b from its activation. Atherosclerosis. in press
7. J. Fang, T. Sawa, T. Akaike, K. Greish, and H. Maeda: Enhanced chemotherapeutic effect against tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin in combination with anticancer agents. Int. J. Cancer, 109, 1-8 (2004).
8. J. Fang, T. Akaike, and H. Maeda: Antiapoptotic role of heme oxygenase and its potential as an anticancer target. Apoptosis, 9, 27-35 (2004).
9. Hirata, S., Senju, S., Matsuyoshi, H., Fukuma, D., Uemura, Y. and Nishimura, Y. Prevention of experimental autoimmune encephalomyelitis by transfer of ES cell-derived dendritic cells expressing MOG peptide along with TRAIL or PD-L1. J.
Immunol. 174, 1888-1897(2005).
10. Tsukamoto, H., Irie, A., and Nishimura, Y. B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor. J. Biol. Chem. 279, 48457-48465(2004).
11. Nakatsura, T., Komori, H., Kubo, T., Yoshitake, Y., Senju, S., Katagiri, T., Furukawa, Y., Oagawa, M., Nakamura, Y., and Nishimura, Y. Mouse homologue of a novel human oncofetal antigen, Glypican-3, evokes T cell-mediated tumor rejection without autoimmune reactions in mice. Clin. Cancer Res 10, 8630-8640(2004).
12. Nakatsura, T., Kageshita, T., Ito, S., Wakamatsu, K., Monji, M., Ikuta, Y., Senju, S., Ono, T. and Nishimura, Y. Identification of glypican-3 as a novel tumor marker for melanoma. Clin. Cancer Res. 10, 6612-6621(2004).
13. Yoshitake, Y., Nakatsura, T., Monji, M., Senju, S., Matsuyoshi, H., Tsukamoto, H., Hosaka, S., Komori, H., Fukuma, D., Ikuta, Y., Katagiri, T., Furukawa, Y., Ito, H., Shinohara, M., Nakamura, Y., and Nishimura, Y.: Proliferation potential-related protein, an ideal esophageal cancer antigen for immnotherapy, identified using complementary DNA microarray analysis. Clin. Cancer Res. 10, 6437-6448(2004).
14. Monji, M., Nakatsura, T., Senju, S., Yoshitake, Y., Sawatsubashi, M., Shinohara, M., Kageshita, T., Ono, T., Inokuchi, A. and Nishimura, Y. Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses. Clin. Cancer Res. 10, 6047-6057(2004).
15. Ohkura, T., Taniguchi, S.,Yamada, K., Nishio, N., Okamura, T., Yoshida, A., Kamijou, K., Fukata, S., Kuma, K., Inoue, Y., Hisatome, I., Senju, S., Nishimura Y., Shigemasa, C. Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves disease. Biochem. Biophys. Res. Comm. 321, 432-440(2004).
16. Tanaka, T., Soejima, H., Hirai, N., Sakamoto, T., Yoshimura, M., Kajiwara, I., Miyao, Y., Fujimoto, K., Miyagi, H., Irie, A., Nishimura, Y., Ogawa, H. Comparison of frequency of interferon-gamma-positive CD4+ T cells before and after percutaneous coronary intervention and the effect of statin therapy in patients with stable angina pectoris. Am. J. Cardiol. 93, 1547-1549(2004).
17. Matsuyoshi, H., Senju, S., Hirata, S., Yoshitake, Y., Fukuma, D., Motomura, Y., Nishimura Y. Cancer immunotherapy by genetically modified embryonic stem cell-derived dendritic cells.
In immunology 2004 (The proceeding of the 12th International Congress of Immunology, ed. By Skamene, E.) Medimond S.r.l.
(Bologna, Italy), 487-491(2004).
18. Khuda. SE., Yoshida, M., Xing, Y., Shimasaki, T., Takeya, M., Kuwahara, K., Sakaguchi, N. : The Sac3 homologue shd1 is involved in mitogenic progression in mammalian cells., J. Biol.
Chem., 279, Issue 44, 46182-46190 (2004)
19. Terada, K., Yomogida, K., Imai, T., Kiyonari, H., Takeda, N., Kadomatsu, T., Yano, M., Aizawa, S., Mori, M.: A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J., 24(3), 611-622(2005) 20. Feng, L., Yunoue, S., Tokuo, H., Ozawa, T., Zhang, D.,
Patrakitkomjorn, S., Ichimura, T., Saya, H., and Araki, N.: PKA phosphorylation and 14-3-3 interaction regulate the function of Neurofibromatosis Type I tumor suppressor, neurofibromin.
FEBS Letters, 557, 275-282, 2004.
21. Iida, S., Hirota, T., Morisaki, T., Marumoto, T., Hara, T., Kuninaka, S., Honda, S., Kosai, K., Kawasuji, M., Pallas, D.C. and Saya, H.:
The tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Oncogene, 23, 5266-5274, 2004.
22. Marumoto, T., Zhang, D. and Saya, H.: Aurora A ‒ A guardian of poles. Nat. Rev. Cancer 5, 42-50(2005).
23. Hiroko Tomiyama, Hiroshi Takata, Tomoko Matsuda, and Masafumi Takiguchi: Phenotypic classification of human CD8+
T cells reflecting their function: An inverse correlation between quantitative expression of CD27 and cytotoxic effector function.
Eur. J. Immunol. 34: 999-1010, 2004.
24. Hiroshi Takata, Hiroko Tomiyama, Mamoru Fujiwara, Naoki Kobayashi, and Masafumi Takiguchi: Cutting Edge: Expression of Chemokine Receptor CXCR1 on Human Effector CD8+ T Cells. J.
Immunol. 173: 2231-2235, 2004.
25. Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi Oka, and Masafumi Takiguchi: Functionally impaired HIV-specific CD8 T cells show high-affinity T cell receptor-ligand interactions.
J. Immunol. 173: 5451-5457, 2004.
26. Takamasa Ueno, Mamoru Fujiwara, Hiroko Tomiyama, Masafumi Onodera, Masafumi Takiguchi: Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific αβ TCR genes, Eur. J. Immunol., 34(12): 3379-3388, 2004.
27. Naoki Kobayashi, Hiroshi Takata, Shumpei Yokota and Masafumi Takiguchi: Down-regulation of CXCR4 expression on human CD8+ T cells during peripheral differentiation, Eur. J. Immunol., 34(12): 3370-3378, 2004.
28. Fukuda, T., Sakai, M., Takano, H., Ono, K. and Takio, S.:
Hypermethylation of retrotransposons in the liverwort Marchantia paleacea var. diptera. Plant Cell Reports 22, 594-598(2004).
29. Murao, K., Takamiya, M., Kanji, O., Takano, H. and Takio, S.:
Copper deficiency induced expression of Fe-superoxide dismutase gene in the fern, Matteuccia struthiopteris. Plant Physiol. Biochem. 42, 143-148(2004).
30. Sakaguchi, S., Fukuda, T., Takano, H., Ono, K., and Takio, S.:
Photosynthetic Electron Transport Differentially Regulates the Expression of Superoxide Dismutase Genes in Liverwort, Marchantia paleacea var. diptera. Plant Cell Physiol. 45, 318-324(2004).
31. Lin, X., Zhang, W., Takano, H., Takio, S. and Ono, K.: Efficient plant regeneration and micropropagation from callus derived from mature zygotic embryos of Larix gmelinii (Rupr.) Kuz. Plant Biotech., 21, 159-163(2004).
32. Matsuzaki, M., Misumi, O., Tadasu, S., Maruyama, S., Takahara, M., Miyagishima, S., Mori, T., Nishida, K., Yagisawa, F., Nishida, K., Yoshida, Y., Nishimura, Y., Nakao, S., Kobayashi, T., Momoyama, Y., Higashiyama, T., Minoda, A., Sano, M., Nomoto, H., Hayashi, H., Ohta, F., Nishizaka, S., Haga, S., Miura, S., Morishita, T., Kabeya, K., Terasawa, Y., Suzuki, Y. Ishii, Y., Asakawa, S., Takano, H., Ohta, N., Kuroiwa, H., Tanaka, K., Shimizu, N., Sugano, S., Sato, N., Nozaki, H., Ogasawara, N., Kohara Y., & Kuroiwa, T.:
Genome sequence of the ultrasmall unicellulat red alga Cyanidioschyzon merolae 10D. Nature, 428, 653-657(2004).
33. Sakai, A., Takano, H. and Kuroiwa, T.: Organelle-Nuclei in Higher Plants: Structure, Composition, Function, and Evolution. Int. Rev.
Cytol., 238, 59-118(2004).
34. Harashima, S., Takano, H., Ono, K. and Takio, S. (2004) Chalcone synthase-like gene in the liverwort Marchantia paleacea var. diptera. Plant Cell Rep., 23, 167-173(2004).
35. Zhang, W., Lin, X., Takano, H., Takio, S. and Ono, K.: Efficient plant regeneration from suspension cells of Allium cepa L. Plant Cell Rep., 23, 371-376(2004).
36. Anraku, M., Kitamura, K., Shinohara, A., Adachi, M., Suenaga, A., Maruyama, T., Miyanaka, K., Miyoshi, T., Shiraishi, N., Nonoguchi, H., Otagiri, M., Tomita, K. : Intravenous iron administration indeces oxidation of serum albumin in hemodialysis patients.
Kidney Int., 66, 841-848 (2004).
37. Matsushita, S., Isima, Y., Chuang, VTG., Watanabe, H., Tanase, S., Maruyama, T., Otagiri, M. : Functional analysis of recombinant human serum albumin domains for pharmaceutical applications.
Pharm. Res., 21, 1924-1932 (2004).
38. Katsuki, M., Chuang, VTG., Nishi, K., Suenaga, A., Otagiri, M. : Tryptophan residues play an important role in the extraordinarily high affinity binding interaction of UCN-01 to human alpha-1-acid glycoprotein. Pharm. Res.,21, 1648-1655 (2004).
39. Katsuki, M., Chuang, VTG., Nishi, K., Kawahara, K., Nakayama, H., Yamaotsu, N., Hirono, S., Otagiri, M. : Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human alpha1-acid glycoprotein. J. Biol. Chem., 280, 1384-1391 (2005).
40. Deguchi, T., Kouno, Y., Terasaki, A., Otagiri, M. : Differential contributions of rOat1(Slc22a6) and rOat3(Slc22a8) to the in vivo renal uptake of uremic toxins in rats. Pharm. Res., 22, 619-627 (2005).
41. Furukawa, K., Hori, M., Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y., Miyazaki, A., Nakayama, H., Horiuchi, S.:
Adiponectin down-regulates acyl-coenzyme A:cholesterol acyltransferase-1 in cultured human monocyte-derived macrophages. Biochem. Biophys. Res. Commun., 317, 831-836 (2004).
42. Unno, Y., Sakai, M., Sakamoto, Y., Kuniyasu, A., Nakayama, H., Nagai, R., Horiuchi, S.: Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36. Biochem. Biophys. Res.
Commun., 325, 151-156 (2004).
43. Katsuki, M., Chuang, V.T., Nishi, K., Kawahara, K., Nakayama, H., Yamaotsu, N., Hirono, S., Otagiri, M.: Use of photoaffinity labeling
and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human alpha1-acid glycoprotein. J. Biol. Chem., 280, 1384-1391 (2005).
44. Tanaka H, Miake J, Notsu T, Sonyama K, Sasaki N, Iitsuka K, Kato M, Taniguchi S, Igawa O, Yoshida A, Shigemasa C, Hoshikawa Y, Kurata Y, Kuniyasu A, Nakayama H, Inagaki N, Nanba E, Shiota G, Morisaki T, Ninomiya H, Kitakaze M, Hisatome I.: Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+
channel blocker aprindine.Biochem Biophys Res Commun., 331, 1001-1006 (2005).
45. *Watanabe, K., *Tateishi, S ., Kawasuji, M ., Tsurimoto, T., InoueH.
and Yamaizumi, M.: Rad18 guides pol to replication stalling sites through physical interaction and PCNA monoubiquitination. The EMBO Journal, Vol. 23: 3886-3896, (2004) *equal contribution
46. Matsuo, T., Matsumura, T., Sakai, M., Senokuchi, T., Yano, M., Kiritoshi, S., Sonoda, K., Kukidome, D., Pestell, R. G., Brownlee, M., Nishikawa, T., and Araki, E. 15d-PGJ(2) inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. Biochem Biophys Res Commun. 314:817-823, 2004.
47. Senokuchi, T., Matsumura, T., Sakai, M., Matsuo, T., Yano, M., Kiritoshi, S., Sonoda, K., Kukidome, D., Nishikawa, T., and Araki, E.
Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase mediate macrophage proliferation induced by oxidized low-density lipoprotein. Atherosclerosis. 176:233-245, 2004.
48. Uekama, K., Hirayama, F., Arima, H.: Pharmaceutical Applications of Cyclodextrins and Their Derivatives. "Handbook of Cyclodextrins and Their Complexes", Ed. by H. Dodziuk, Wiley-VCH Verlag, Weinheim, (2005), in press.
49. Arima, H.: Dendrimers as DNA Carriers, “Non-viral Gene Therapy: Gene Design and Delivery”, Eds. K. Taira, K. Kataoka, T.
Niidome, Springer-Verlag Tokyo, Tokyo, pp. 75-86 (2005).
50. Arima, H.: Recent Findings of Dendrimers and Their Conjugates as Non-viral Vectors. "Recent Research and Development of Bioconjugate Chemistry", Transworld Research Network, Kerala,
India, pp. 109-126 (2005).
51. Wada, K., Arima, H., Hattori, K., Hirayama, F., Uekama, K.:
Improvement of Gene Delivery Mediated by Mannosylated Dendrimer/a-Cyclodextrin Conjugates. J. Control. Release., 104, 397-413 (2005).
52. Motoyama, K., Arima, H., Miyake, K., Hirayama, F., Uekama, K.:
Involvement of CD14 in the inhibitory effects of dimetyl-a-cyclodextrin on lipopolysaccharide signaling in macrophages.
FEBS Lett., 579, 1707-1714 (2005).
53. Wada, K., Arima, H., Hattori, K., Hirayama, F., Uekama, K.:
Enhancing Effects of Galactosylated Dendrimer/a-Cyclodextrin Conjugates on Gene Transfer Efficiency. Biol. Pharm. Bull., 28, 500-505 (2005).
54. Uekama, K.: Design and evaluation of cyclodextrin-based drug formulation. Chem. Pharm. Bull., 52, 900-915 (2004).
55. Arima, H., Yunomae, K., Morikawa, T., Hirayama, F., Uekama, K:.
Contribution of Cholesterol and Phospholipids to Inhibitory Effect of Dimethyl-b-cyclodextrin on Efflux Function of P-glycoprotein and Multidrug Resistance-associated Protein 2 (MRP2) in Vinblastine-resistant Caco-2 Cell Monolayers. Pharm. Res., 21, 625-634 (2004).
56. He, G-X., Kuroda, T., Mima, T., Morita, Y., Mizushima, T. and Tsuchiya, T. : An H+-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa. J. Bacteriol. 186, 262-265. (2004)
57. Tomisato, W., Tsutsumi, S., Hoshino, T., Hwang, H-J., Mio, M., Tsuchiya, T. and Mizushima, T. : Role of direct cytotoxic effects of NSAIDs in the induction of gastric lesions. Biochem.
Pharmacol. 67, 575-585. (2004)
58. Shiota, S., Shimizu, M., Sugiyama, J., Morita, Y., Mizushima, T., and Tsuchiya, T. : Restoration of effectiveness of beta-lactams on methicillin-resistant staphylococcus aureus by tellimagrandin I from rose red. Microbiol. Immunol. 48, 67-73. (2004)
59. Takahashi, N., Yamaguchi, Y., Yamairi, H., Makise, M., Takenaka,
H., Tsuchiya, T. and Mizushima, T. : Analysis on Origin Recognition Complex containing Orc5p with defective Walker A motif. J. Biol. Chem. 279, 8469-8477. (2004)
60. Tanaka, K., Nishimoto, K., Tomisato, W., Tsutsumi, S., Hoshino, T., Tsuchiya, T. and Mizushima, T. : Adaptive cytoprotection induced by pre-treatment with ethanol protects against gastric cell damage by NSAIDs. Dig. Dis. Sci. 49, 210-217. (2004) 61. Kuroda, T., Fujita, N., Utsugi, J., Kuroda, M., Mizushima, T. and
Tsuchiya T. : A major Li(+) extrusion system NhaB of Pseudomonas aeruginosa : Comparison with the major Na(+) extrusion system NhaP. Microbiol. Immunol. 48, 243-250.
(2004)
62. Takenaka, H., Makise, M., Kuwae, W., Takahashi, N., Tsuchiya, T.
and Mizushima, T. : ADP-binding to Origin Recognition Complex of Saccharomyces cerevisiae. J. Mol. Biol. 340, 29-37. (2004) 63. Tsutsumi, S., Gotoh, T., Mima, S., Tomisato, W., Hoshino, T.,
Hwang, H-J., Mori, M., Tsuchiya, T. and Mizushima, T. : NSAIDs induce apoptosis through endoplasmic reticulum stress response in gastric mucosal cells. Cell Death Differ. 11, 1009-1016. (2004)
64. Tanaka, K., Tomisato, W., Tsutsumi, S., Hoshino, T., Tsuchiya, T.
and Mizushima, T. : Cytotoxic synergy between indomethacin and hydrochloric acid in gastric mucosal cells. Biol. Pharm. Bull.27, 1188-1192. (2004)
65. Tomisato, W., Tanaka, K., Katsu, T., Kakuta, H., Sasaki, K., Tsutsumi, S., Hoshino, T., Aburaya, M., Li, D., Tsuchiya, T., Suzuki, K., Yokomizo, K., and Mizushima, T. : Membrane permeabilization by non-steroidal anti-inflammatory drugs. Biochem. Biophys. Res.
Commun. 323, 1032-1039. (2004)
66. Jun-ichi Yoshida and Tokio Tani: Hsp16p is required for thermotolerance in nuclear mRNA export in fission yeast Schizosaccharomyces pombe, Cell Structure and Function, 29, 125-138 (2005)
67. Tomoko Andoh, Abul Kalam Azad, Asako Shigematsu, Yasumi Ohshima and Tokio Tani: The fission yeast ptr1+ gene involved in nuclear mRNA export encodes a putative ubiquitin ligase, Biochem. Biophys. Res. Commun, 317, 1138-1143 (2004) 68. Takashi Ideue, Abul Kalam Azad, Jun-ichi Yoshida, Tadao
Matsusaka, Mitsuhiro Yanagida, Yasumi Ohshima and Tokio Tani: The nucleolus is involved in mRNA export from the nucleus in fission yeast, J. Cell Sci., 117, 2887-2895 (2004)
69. Ihara, T., Fujii, T., Mukae, M., Kitamura, Y., Jyo, A.: Photochemical Ligation of DNA Conjugates through Anthracene Cyclodimer Formation and Its Fidelity to the Template Sequences. J. Am.
Chem. Soc., 126, 8880-8881 (2004).
70. Ihara, T., Tanaka, S., Chikaura, Y., Jyo, A.: Preparation of DNA-Modified Nanoparticles and Preliminary Study for Colorimetric SNP Analysis Using Their Selective Aggregations. Nucleic Acids Res., 32, e105 (2004).
71. Ihara, T., Shirasaka, Y., Sato, Y., Kitamura, Y., Okada, K., Tazaki, M., Jyo, A.: Synthesis of the Amidite Reagent to Built Bipyridine Units into DNA Backbone. Heterocycles, 65, 293-301 (2005).
72. N. Momoshima, M. Takamura, Y. Nagao, T. Toyoshima, T. Okai and T. Uda: Development of sampling apparatus for atmospheric tritium, “Radioecology and Environmental Dosimetry”, Edited by J. Inaba, H. Tsukada & A. Takeda, Institute for Environmental Sciences, Japan, pp.416-420 (2004)
73. Kojima, A., Tomiguchi, S., Kawanaka, K., Utsunomiya, D., Shiraishi, S., Nakaura, T., Katsuda, N., Matsumoto, M., Yamashita, Y., Motomura, N., Ichihara, T.: Attenuation correction using asymmetric fan-beam transmission ct on two-head spect system. Ann. Nucl. Med., 18(4), 315-322(2004).
74. Kojima, A., Kawanaka, K., Nakaura, T., Shiraishi, Utsunomiya, D., Katsuda, N., Tomiguchi, S., Yamashita, Y., Matsumoto, M., Motomura, N., Ichihara, T.: Attenuation correction using combination of a parallel hole collimator and an uncollimated non-uniform line array source. Ann. Nucl. Med., 18(5), 385-390(2004).
75. Khuda. SE., Yoshida, M., Xing, Y., Shimasaki, T., Takeya, M., Kuwahara, K., Sakaguchi, N.: The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells., J. Biol. Chem.,
279, Issue 44, 46182-46190(2004).
76. Morita, N., Takamura, N., Ashizawa, K., Shimasaki, T., Yamashita, S., Okumura, Y.: Measurement of the whole-body Cs-137 in residents around the chernobyl nuclear power plant. Radiation Protection Dosimetry Advance Access published online on February 9, 2005 (in Press).
論文（和文）
1. 永井竜児、海野雄加、堀内正公：グリケーションと老化、日本アフ
ェレシス学会雑誌23 (2) 151-157(2004).
2. 永井竜児：AGE、糖尿病診療辞典 第２版、繁田幸男、景山茂、石 井均監修、医学書院、499‐500(2004).
3. 永井竜児：AGE阻害薬、糖尿病診療辞典 第２版、繁田幸男、景山 茂、石井均監修、医学書院、501(2004).
4. 永井竜児、坂田則行、堀内正公：AGEと動脈硬化、糖尿病・代謝症 候群の合併症、門脇孝、小川佳宏、下村伊一郎監修、医歯薬出版株 式会社、511-514(2004).
5. 高木香織、坂本裕一郎、堀内正公：AGE受容体、今泉 勉監修、メ ディカルレビュー社、79-88(2004).
6. 坂本裕一郎、堀内正公：動脈硬化におけるAGE受容体の意義-SR-A を中心として、Diabetes Frontier、メディカルレビュー社、177-182(2004).
7. 永井竜児、高木香織、坂本裕一郎、堀内正公：マクロファージ、酸
化ストレスナビゲーター、倉林正彦監修、株式会社メディカルレビ ュー社、64‐65(2005).
8. 松吉秀武，千住 覚，西村泰治，抗原とケモカインを共発現させた ES細胞由来の樹状細胞を用いた抗腫瘍免疫療法，臨床免疫，42(1)、
110-114(2004).
9. 松吉秀武，千住 覚，西村泰治，ES細胞由来の樹状細胞による免疫 制御，感染、炎症、免疫̶連載：ビジュアルデビュー，34(2)、32-39(2004).
10. 中面哲也，西村泰治，腫瘍抗原ペプチドを駆使した癌免疫療法の新 展開，実験医学，第22巻5号（増刊；免疫研究のフロンティア），
215-220(2004).
11. 中面哲也，西村泰治，cDNAマイクロアレイ解析による腫瘍特異抗 原の探索，臨床免疫，41(4)、369-378(2004).
12. 中面哲也，西村泰治，cDNAマイクロアレイ解析による腫瘍特異抗 原の探索「肝細胞癌の腫瘍マーカーおよび腫瘍特異抗原としての Glypican-3(GPC3)の同定；その臨床応用への可能性，医学をゲノム する（第27回阿蘇シンポジウム記録2003），115-127(2004).
13. 平田真哉，西村泰治，疾患感受性遺伝子：HLA-DRB1遺伝子，日本 臨牀2005年増刊：関節リウマチ，日本臨牀社（大阪）, 117-121(2005).
14. 平田真哉, 千住覚, 西村泰治「抗原提示細胞をターゲットとした免疫 抑制法」, Mebio, メジカルビュー社(東京), 21(10)、33-41(2004).
15. 平田真哉, 千住覚, 西村泰治「抗原提示細胞をターゲットとした免疫 抑制療法」，分子リウマチ，2（1）、47-54(2005).
16. ヒト腎癌細胞の腫瘍関連B7-H1を介する浸潤リンパ球からの免疫逃 避機構とその遮断効果、腎癌研究会会報、28(3)、25-29(2005)．
17. 有馬英俊、上釜兼人：シクロデキストリンによる蛋白質・ペプチド 性薬物の経粘膜吸収の改善, Drug Delivery System, in press (2005).
18. 有馬英俊：機能性核酸に対するデリバリーシステム(2): siRNA デリ バリーシステム, Antisense, 9(1), 5-29 (2005).
19. 有馬英俊：遺伝子導入法としてのポリフェクション： α-シクロデ キストリンを基本素材とする高機能性遺伝子導入用ベクターの構築 を中心として, 薬学雑誌, 127, 451-464 (2004).
20. 有馬英俊：機能性核酸に対するデリバリーシステム(1): 遺伝子デリ バリーシステム，Antisense, 8, 5-21 (2004).
21. 有馬英俊：敗血症を抑制するシクロデキストリン誘導体の開発, 佐 川先端科学技術振興財団第16回助成研究報告書, 73-80 (2004).
22. 上釜兼人: 多機能性薬物担体としてのシクロデキストリンの製剤へ の応用, 薬学雑誌, 124, 909-935 (2004).
23. 川原浩一、森 正敬、中山 仁: ミクログリアにおける NO 誘導性 アポトーシスと小胞体ストレス, 日本薬理学雑誌 Vol. 124、399-406 (2004).
24. 谷時雄、安東知子：イーストトラフィック：mRNA 細胞内輸送のし くみと制御、実験医学、vol.22、2447-2453 (2004)
25. 森田直子、芦澤潔人、高村 昇、島崎達也、山下俊一、奥村 寛:
旧ソ連邦居住者の体内被曝の検討,広島医学 Vol.57(4)、371-373(2004).
学会発表（国際学会）
1. A irie, H Tsukamoto, J-R Kim, Y Nishimura: PKD2 Is Involved in the TCR Stimulated Activation Pathway That Is Independent of ZAP-70 Activation, 12th International Congress of Immunology and 4th Annual Conference of FOCIS, July 18-23,2004 Montreal 2. 西 村泰 治： Identification of novel human tumor rejection
antigens using a genome-wide cDNA microarray analysis, SARS 共同研究（北京），2004 年10 月14 日．
3. Kawatani K, Igarashi H, Kuwahara K, and Sakaguchi N.:
Regulation of double strand DNA breaks in immunoglbulin V region gene by GANP expression in germinal center B cells.第12 回国際免疫学会総会(カナダ モントリオール）,平成１６年７月１ ８̶２３日
4. Saya H: Aurora-A-dependent phosphorylation of CENP-A in prophase is essential for concentration of Aurora-B at inner centromeres and for kinetochore function. The 5th UK-Japan Cell Cycle Workshop. 04/13/2004-04/16/2004, Nara-ken New Public Hall, Nara, Japan
5. Saya H: Cell cycle checkpoint abnormalities in malignant brain tumors. Special Lecture in 2004 Annual Meeting of Korean Brain Tumor Society Meeting. 06/26/2004, Auditorium, Ajou University Hospital, Suwon, Korea.
6. Saya H: Role of Aurora kinases in mitotic regulation and tumorigenesis. International Symposium of Grant-in-aid for Scientific Research on Priority Areas ʻCancerʼ, “Global Trends in Cancer Research”, 07/01/2004-07/02/2004, Hitotsubashi Memorial Hall, Tokyo, Japan
7. Saya H: Roles of Aurora-A kinase in mitotic progression. Gordon Research Conference on Cancer: Models and Mechanisms, 08/01/2004-08/06/2004, New Port, RI, USA
8. Kuninaka S, Nomura M, Iida S, Hara T, Yonehara S and Saya H:
The tumor suppressor WARTS activates the Omi/HtrA2-dependent pathway of cell death. Gordon Research Conference:
Cancer Models and Mechanisms, 08/01/2004-08/06/2004, New Port, RI, USA
9. Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H: Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function.
08/01/2004-08/06/2004, New Port, RI, USA
10. Kuninaka S, Nomura M, Iida S, Hara T, Yonehara S and Saya H:
The tumor suppressor WARTS activates the Omi/HtrA2-dependent pathway of cell death. Keystone Symposia: Cancer and Development, 02/05/2005-02/10/2005, Canada 11. Machida, M., Takechi, K., Takio, S., Hasebe, M., Takano, H.:
Relationship between plastid biogenesis and genes of peptidoglycan synthesis pathway in Physcomitrella patens. Moss 2004, Sep. 12-15, Freiburg in Germany
12. Takano, H.: Invitation to plant sciences. US-Japan International Workshop in Bioelectrics, Mar. 16, 2005, Norfolk, VA, USA 13. Katsuki, M., Chuang, VTG., Kawahara, K., Nishi, K., Nakayama,H.,
Suenaga,A., Otagiri,M. : Trp160 of human alpha-1-acid glycoprotein may involved in the high affinity binding of UCN-01.
Pharmaceutical Sciences World Congress (PSWC 2004) (Kyoto), May 30-June 3, 2004.
14. Iwao,Y., Anraku,M., Kawai,K., Ulrich Kragh-Hansen, Otagiri,M. : Structural and functional characterization of mutants of human serum albumin with a decreased physiological half-life.
Pharmaceutical Sciences World Congress (PSWC 2004) (Kyoto), May 30-June 3, 2004.
15. Kawahara K., Hyohdou A., Mori M., Nakayama H.: Different regulation of two types of microglia for hippocampal neuronal cell death after treatment of LPS and IFNg. The 3rd international conference on the biology, chemistry and therapeutic applications of nitric oxide (Nara), 2004.5.26.
16. Kawahara K., Shimizu E., Sawada M., Nakayama H.: Role of anti-inflammatory cytokines on b-amyloid clearance in rat primary microglia. 34th Annual Meeting of Society for Neuroscience (San Diego, USA), 2004.10.24.
17. HIGUCHI S., SHIMADA J., TSUJIMURA M., ABE Y. and DAVAA G. : Groundwater flow system in Kherlen river basin revealed by environmental tritium． RAISE International Workshop( Tsukuba Univ.), 2004.11.
18. Uekama, K.: Cyclodextrin-Drug Conjugates for Colonic Delivery.
2004 AAPS Pharmaceutics and Drug Delivery Conference, Philadelphia, PA, USA, June 7-9 (2004).
19. Wada, K., Tsutsumi, T., Arima, H., Hirayama, F., Uekama, K.:
Improvement of Transfection Efficiency Mediated by Glycosylated Dendrimer/α-Cyclodextrin Conjugate.
Pharmaceutical Sciences World Conference, Kyoto, Japan, May 29-June 3 (2004).
20. Hagiwara, Y., Arima, H., Hirayama, F., Uekama, K.: Modification of Biopharmaceutical Properties of Doxorubicin by Cyclodextrin/liposome Carrier. Pharmaceutical Sciences World Conference, Kyoto, Japan, May 29-June 3 (2004).
21. Yamasaki, Y., Hagiwara, Y., Miyake, K., Arima, H., Hirayama, F., Uekama, K.: Effects of Bile Acids on Intestinal Absorption of Itraconazole Solution Containing Cyclodextrins. Pharmaceutical Sciences World Conference, Kyoto, Japan, May 29-June 3 (2004).
22. Arima, H., Tsutsumi, T., Wada, K., Hirayama, F., Uekama, K.:
Dendrimer/α-Cyclodextrin Conjugate as a Novel Carrier of siRNA. Pharmaceutical Sciences World Conference, Kyoto, Japan, May 29-June 3 (2004).
23. Arima, H.: Enhancing Mechanism of Oral Bioavailability by Cyclodextrins. 12th International Cyclodextrin Symposium, Montpiller, France, May 16-20 (2004).
24. Uekama, K.: Potential Use of Cyclodextrins in Peptide and Protein Delivery. European Conference on Drug Delivery and Pharmaceutical Technology, Sevilla, Spain, May 10-12 (2004) 25. Ihara, T., Fujii, T., Mukae, M., Kitamura, Y., Okada, K., Tazaki, M.,
Jyo, A.: Specific DNA Labeling Based on Cooperative Hybridization of the Functional DNA Conjugates. World Conference on Dosing of Antiinfectives (N�rnberg), Sept., 2004
26. Ihara, T., Kitamura, Y., Tsujimura, Y., Jyo, A.: Metal Ion-Directed Cooperative DNA Labeling by Functional DNA Conjugates.
International Symposium on Nano-organization and Function (Tokyo), Nov., 2004
27. Tanaka, S., Ihara, T., Jyo, A.: DNA Immobilization onto the Nanospheres and the Basic Studies on the Colorimetric Allele Analysis. Fourth International Symposium on Microchemistry and Microsystems (ISMM 2004) (Takamatsu), Nov., 2004 28. Kitamura, Y., Tsujimura, Y., Okada, K., Tazaki, M., Ihara, T., Jyo,
A.: Cooperative Hybridization of DNA Conjugates Carrying Metal Chelators and Its Analytical Application to Gene Detection.
229th ACS National Meetings (San Diego), March 2005 29. N. Momoshima, Y. Nagao, T. Toyoshima: ELECTROLYTIC
ENRICHMENT OF TRITIUM WITH SOLID POLYMER ELECTROLYTE FOR APPLICATION TO ENVIRONMENTAL MEASUREMENTS, 7th International Conference on Tritium Science and Technology, September 12-17, 2004 Kongresshaus Baden-Baden 、 Germany
30. Shimasaki, T., M., Kojima, A., Horiuchi, S., Miyamoto, E., Okumura, Y.: Determining radiation exposure of Nagasaki atomic bomb survivors using dental enamel. 11th International Congress of the International Radiation Protection Association, 2004.5.23-28, Madrid, Spain.
31. Kojima, A., Tomiguchi, S., Katsuda, N., Matsumoto, M., Yamashita, Y., Noguchi, T., Takaki, A.: Study on optimum setting of energy window for effective Tl-201 imaging. EANM 2004 Helsinki, 2004.9.4�8, Helsink, Finland.
32. Matsuda, N., Shimasaki, T., Yoshida, M., Kojima, A., Takao, H., Kaneko, M., Shiraishi, Y., Horiuchi, S., Okumura, Y.: Effect of pre-entry instruction as an additional part of radiation training beginners course on reduction of radioactive contamination in two independent unsealed radioisotope facilities., 3rd