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【4】研 究 成 果 公 表 論 文 等
1) 学
2) 学
3) 総
4) 記 5) 特
会
堅さ璽
ヒ王コ
誌 等
発 表･招 待 講 演
説
事
許
1) 学 会 誌 等
1.北薄春樹,膏藤忠夫; ｢乳酸菌からの免疫活性DNAモチーフの発見と"生 体防御食品"への応用. ｣ミニレビュー.わが国における乳酸菌のフロンティ
ア研究.日本農芸化学会誌, 76, 833‑836 (2002).
2.Takeshi Shimosato, Haruki Kitazawa, Shinichiro Katoh, Yoshihisa Tomioka, Risuke Karima, Satoshi Ueha, Yasushi Kawai, Takanori Hishinuma,
Koujj Matsushima and Tadao Saito; Swine To川‑like receptor 9 recognizes
CpG motifs of human ce" stimulant. Biochm. BI'ophys. Acta, 1 627, 56‑61 (2003).
31Haruki Kitazawa, Hiroshi Watanabe, Takeshi Shimosato, Yasushi Kawai, TakatoshHtoh and Tadao Saito; lmmunostimuratory oligonucleotide, CpG‑
like motif exists jn from Lactobacillus de/brueckii ssp･ bu/garI'cus N)AI B6.
lnt. J. FoodMicrobio/., 85, l 1‑21 (2003).
4.Takeshi Shimosato, Haruki Kitazawa, Masanori Tohno, Shinichiro Katoh, Yasushi Kawai, Tadao Saito; Development of immune assay system for both CpG and non‑CpG DNA from lactic acid bacteria uslng a transfectant of swine TolHike receptor 9･ Animal ScI'ence Jouma/. in press.
5･Takeshi Shimosato, Masanori Tohno, Shinichjro Katoh, Kouichi Watanabe,
Yasushi Kawai, Hisashi Aso, Takahiro Yamaguchj, Tadao Saito and Haruki
Kitazawa; To"〕ike receptor 9 expresses on M cells of follicle‑associated
epithelia in swine Peyer's patches, CeI/&Tissue Research., submitted
6･Shinichiro Katoh, Takeshi Shimosato, Masanori Tohno, Yasushi Kawai Tadao Saito and Harukj Kitazawa; CIomng and characterization of swine lnterleukin‑1 7 preferentjally expressed in intestine. J. /nterferon CytokI'ne Res., submitted.
2) 学 会 発 表･招 待 講 演
[学会発表]
1.北穿春樹,下里剛士,川井 泰,膏藤忠夫;
乳酸菌DNAモチーフの腸管バイエル板細胞による取り込みとサイトカインネ ットワークの制御
日本畜産学会 第100回大会 講演要旨集, p.177,2002.
2.下里剛士,北薄春樹,川井 奉,斎藤忠夫;
ブタToMke receptor 9 (sTLR9)の腸管バイエル板からのクローニングとそ
の発現解析
日本農芸化学会 2002年度大会 講演要旨集, p.280, 2002. (学会トピック スに採択)
3･北弄春樹,加藤真一郎,下里剛士,川井 泰,棄藤忠夫;
乳酸菌遺伝子データバンクを用いたCpG DNAモチーフの検索と同モチーフを 含む合成オリゴDNAの免疫活性
日本畜産学会 第101回大会 講演要旨集, p.163,2003.
4.下里剛士､北弄春樹､川井 泰､膏藤忠夫
ブタTo=一日ke receptor (STLR) 9発現細胞系の構築とその利用 日本畜産学会 第102回大会 講演要旨集, p.69,2003.
5.北淳春樹､下里剛士､川井 泰､膏藤忠夫
ブタToJHike receptor (STLR) 9による乳酸菌DNAモチーフの認識性 日本畜産学会 第102回大会 講演要旨集, p.69,2003.
6･遠野雅徳､北弄春樹､下里剛士､加藤真一郎､川井 泰､渡遺康一､山口高 弘､斎藤忠夫
ブタTo‖‑like receptor(TLR)9の抗体作製と臓器発現部位の解析 日本畜産学会 第102回大会 講演要旨集, p.70,2003.
7.加藤真一郎､北薄春樹､下里剛士､川井 奉､膏藤忠夫
乳酸菌DNAモチーフによるブタ腸管におけるサイトカインmRNAの発現誘導
日本畜産学会 第102回大会 講演要旨集, p.70,2003.
8･下里剛士,北薄春樹,松本真由美,加藤真一郎,川井 泰,脅藤忠夫 ブタToH‑like receptor(STLR)2のクローニングとその発現解析
日本農芸化学会 2003年度大会 講演要旨集, p.ll,2003.
9･北浮春樹,下里剛士,松本真由美,加藤真一郎,川井 泰,斎藤忠夫
ブタTolHike receptor(STLR)Zに相互作用をもつSTLRlおよび6のクローニ
ングとその発現解析
日本農芸化学会2003年度大会 講演要旨集, pl1, 2003
10･下里剛士,北薄春樹,遠野雅徳,加藤真一郎,川井 泰,膏藤忠夫 ブタTLR9トランスフェクタントによる乳酸菌DNAの免疫評価系の構築
日本畜産学会 第103回大会 講演要旨集, p.,2004.
11･遠野雅徳,北津春樹,下里剛士,加藤真一郎,川井 泰,斎藤忠夫 ブタTLR2トランスフェクタン･トの構築とその利用
日本畜産学会 第103回大会 講演要旨集, p.,2004
12･加藤真一郎,北穿春樹,下里剛士,遠野雅徳,川井 泰,曹藤忠夫 ブタインターロイキン117(IL‑1 7)のクローニングとその特徴
日本畜産学会 第103回大会 講演要旨集, p.,2004.
1,31北薄春樹,加藤真一郎,下里剛士,遠野雅徳,川井 泰,斎藤忠夫 ブタインターフェロン‑γ受容体(肝NTR)のクローニングとその解析
日本畜産学会 第103回大会 講演要旨集, p.,2004.
3) 総
一説北津春樹,膏藤忠夫
｢乳酸菌からの免疫活性DNAモチーフの発見とブタToll様受容体トランスフ ェクタントによる活性評価系の構築｣特集 プロバイオティクスの機能と広が
る応用範囲,食品工業, 46(14), 25‑31 (2003).
4) 記
一事
｢東北大,ブタのTLR単離,ヒトモデルとしての免疫活性化因子スクリ一二ン
̲グに活用｣基礎科学･技術･シ‑ズ,日経バイオテク(2'003年4月14日発行), p.28, 2003.
5) 特 許
1. Toll様レセプター強制発現細胞の利用 特許出願中(特願2003‑172132)