77
78
4㸫1㸬ᗎㄽ
➨3❶ࡼࡾ㸪W1DFࡢⓎ⫱ไᚚ༸ᕢෆ࡛ࡢ㯤యࡢඹᏑࡢ᭷↓ࡀ㔜せ࡛࠶ࡿࡇࡀ
᫂ࡽ࡞ࡗࡓࠋࡑࡇ࡛㸪ᮏ❶࡛ࡣࡇࡢ⌧㇟ࡀἪங∵࠾࠸࡚ࡶྠᵝ㉳ࡇࡿ⌧㇟࡛࠶
ࡿࡢࢆ᫂ࡽࡍࡿࡓࡵ㸪W1DF㯤యࡢ⨨㛵ಀࡀW1DF࠼ࡿᙳ㡪ࢆㄪ
ࡓࠋࡇࢀࡲ࡛㸪㯤యࡀᏑᅾࡍࡿ༸ᕢྠഃࡢᏊᐑゅ࠾ࡅࡿᏊᐑෆ⭷ࡢ⤌⧊୰P4⃰ᗘࡣ㸪
ᑐഃࡢᏊᐑゅ࠾ࡅࡿᏊᐑෆ⭷ẚ㧗࠸ࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸦20㸧ࠋࡲࡓ㸪༸๓
༸⬊ࡀᏑᅾࡍࡿ༸ᕢྠഃࡢ༸⟶ෆE2⃰ᗘࡣ㸪ᑐഃࡢࡶࡢẚ㍑ࡋ࡚㧗࠸ࡇࡀሗ࿌
ࡉࢀ࡚࠸ࡿ㸦99㸧ࠋࡇࢀࡽࡢᐇࡽ㸪༸ᕢྠഃࡢᏊᐑゅࡢ㛫ࡣᐦ᥋࡞ᒁᡤࡢࡘ࡞
ࡀࡾࡀᏑᅾࡋ㸪Ꮚᐑࡀྠഃࡢ༸ᕢࡽศἪࡉࢀࡿᛶࢫࢸࣟࢻ࣍ࣝࣔࣥࡢᙳ㡪ࢆᙉࡃཷ
ࡅ࡚࠸ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡿࠋࡑࡇ࡛㸪ேᕤᤵ⢭ᚋࡢཷ⫾⋡ࡘ࠸࡚㸪ඹᏑ⩌㠀ඹᏑ
⩌࡛ẚ㍑ࡋ㸪W1DF㯤యࡢ⨨㛵ಀࡀ࢘ࢩࡢ⦾Ṫ⏕⌮࠼ࡿᙳ㡪ࢆㄪᰝࡋࡓࠋ
4㸫2㸬ヨ㦂1㸸Ἢங∵࠾ࡅࡿW1DF㯤యࡢඹᏑ࠾ࡼࡧ㠀ඹᏑ㛵ಀࡀW1DF㯤యࡢ
Ⓨ⫱ືែ࠾ࡼࡧ⾑୰P4⃰ᗘ᥎⛣ཬࡰࡍᙳ㡪
4㸫2㸫1㸬౪ヨື≀
ᖏᗈ␆⏘Ꮫ␆⏘ࣇ࣮ࣝࢻ⛉Ꮫࢭࣥࢱ࣮࡚㣫㣴ࡉࢀ࡚࠸ࡿ㸪⮫ᗋⓗᗣ࡛Ⓨ
࿘ᮇࡀṇᖖ࡞࣍ࣝࢫࢱࣥ✀⤒⏘Ἢங∵㸦n㸻30㸪ᖹᆒ⏘ḟ㸸2.2 r 0.2㸪ᖹᆒศፔᚋ᪥ᩘ㸸 99.9s8.0㸪ᖹᆒ᪥ங㔞㸸37.6s1.6 kg㸧ࢆ⏝࠸ࡓࠋ౪ヨࡋࡓಶయࡣ㸪ศፔᚋ௦ㅰᛶᝈ
ࡸ⦾Ṫ㞀ᐖ࡛⒪Ṕࡢ࡞࠸ࡶࡢ࡛࠶ࡿࠋ
4㸫2㸫2㸬ᐇ㦂᪉ἲ
⮬↛ⓎⓎぢᚋ㸪24㛫ẖ┤⭠᳨ᰝࡲࡓࡣ㉸㡢Ἴ⏬ീデ᩿⨨ࢆ⏝࠸࡚༸ࡢ☜ㄆ
ࢆ⾜ࡗࡓࠋ༸☜ㄆ᪥ࢆDay 0ࡋࡓࠋDay 2㸪4㸪6㸪8࠾ࡼࡧ10ࡢ㛫㉸㡢Ἴ⏬ീデ᩿
79
⨨ࢆ⏝࠸࡚༸ᕢࡢほᐹࢆ⾜ࡗࡓࠋࡇࡢ㸪ᖍ༸⬊ࡀ2ࡘ࠶ࡿಶయ㸪ࡲࡓࡣᖍ༸⬊
ࡀ☜ㄆࡉࢀ࡞࠸ಶయࡣヨ㦂ࡼࡾ㝖እࡋࡓࠋࡲࡓ㸪ྠࡌ᪥ṇ୰ᑿ㟼⬦ࡼࡾ᥇⾑ࢆ⾜ࡗࡓࠋ
4㸫2㸫3㸬 ༸ᕢࡢほᐹ
W1DF 㯤యࡢඹᏑࡲࡓࡣ㠀ඹᏑ㛵ಀࡢほᐹࡣ㸪5.0MHz ࡢࣜࢽࣉ࣮ࣟࣈࡀᒓ ࡋࡓ⤒┤⭠㉸㡢Ἴ⏬ീデ᩿⨨㸦HS̺101V㸪ᮏከ㟁Ꮚ㸪ឡ▱㸧ࢆ⏝࠸ࡓࠋ༸ᕢほᐹ
᭱┤ᚄࢆ᭷ࡍࡿ༸⬊ࢆW1DFࡋ㸪W1DFࡀྠ୍༸ᕢෆ㯤యඹᏑࡍࡿሙྜࢆඹᏑ
⩌㸪㯤యࡀᏑᅾࡍࡿ༸ᕢࡣᑐഃࡢ༸ᕢᏑᅾࡍࡿሙྜࢆ㠀ඹᏑ⩌ࡋࡓࠋ
4㸫2㸫4㸬 ༸⬊࠾ࡼࡧ㯤యᙧែࡢほᐹ
ᖍ༸⬊࠾ࡼࡧ㯤యࡢ᩿㠃✚ࡣ㸪5.0MHzࡢࣜࢽࣉ࣮ࣟࣈࡀᒓࡋࡓ⤒┤⭠㉸㡢Ἴ⏬
ീデ᩿⨨㸦HS̺101V㸪ᮏከ㟁Ꮚ㸪ឡ▱㸧ࢆ⏝࠸࡚ ᐃࡋࡓࠋࣉ࣮ࣟࣈࢆᡭᣦࡶ
┤⭠ෆᤄධࡋ㸪ᕥྑ୧ഃ༸ᕢࡢ᩿ᒙീࢆほᐹࡋ㸪ᖍ༸⬊࠾ࡼࡧ㯤యࡢ᩿ᒙ⏬ീࡀ᭱
࡞ࡿࡼ࠺㟼Ṇ⏬ࢆグ㘓ࡋ㸪ࣃࢯࢥࣥୖ㟼Ṇ⏬ࢆ⛣ືࡉࡏ㸪ᖍ༸⬊ࡣ㛗ᚄ▷ᚄࡢᖹ ᆒ್ࢆᖹᆒ┤ᚄࡋ㸪ࢹ࣮ࢱࡋ࡚⏝࠸ࡓࠋ㯤యࡢ᩿㠃✚ࡣ㸪㯤యࡢ᩿ᒙ⏬ീࡀ᭱࡞
ࡿࡼ࠺㟼Ṇ⏬ࢆグ㘓ࡋ㸪ࣃࢯࢥࣥୖ㟼Ṇ⏬ࢆ⛣ືࡉࡏ㸪㯤యࡢ㛗ᚄ▷ᚄࡢᖹᆒ್ࡽ
ᖹᆒ┤ᚄࢆ⟬ฟࡋ㸪㸦ᖹᆒ┤ᚄ㸭2㸧23.14ᙜ࡚ࡣࡵ㯤య᩿㠃✚ࢆ⟬ฟࡋ㸪ࢹ࣮ࢱ⏝
࠸ࡓࠋ
4㸫2㸫5㸬᥇⾑
21G᥇⾑㔪࣊ࣃࣜࣥຍ┿✵᥇⾑⟶㸦࣋ࣀࢪ࢙ࢡࢺϩ┿✵᥇⾑⟶㸪TERUMO㸪ᮾி㸧ࢆ
⏝࠸࡚ᑿ㟼⬦ࡼࡾ10mlࡢ᥇⾑ࢆ⾜ࡗࡓࠋ᥇ྲྀࡋࡓ⾑ᾮࡣịỈ୰࡚ᛴ෭ᚋ㸪4Υ࡛2,000 g㸪 20ศ㛫㐲ᚰࡋ㸪⾑₢ศ㞳ᚋ㸪⾑୰P4⃰ᗘ ᐃࡲ࡛㸫30Υ࡚⤖ಖᏑࡋࡓࠋ
80
4㸫2㸫6㸬⾑୰P4⃰ᗘࡢ ᐃ
Day 2㸪4㸪6㸪8࠾ࡼࡧ10࠾ࡅࡿ⾑୰P4⃰ᗘࡢ ᐃࡣEIAἲࡼࡾ ᐃࡋࡓࠋ ᐃ᪉ἲ
ࡣ➨2❶ྠᵝࡢ᪉ἲ࡛⾜ࡗࡓࠋ⾑୰P4ࡢ ᐃෆኚື࠾ࡼࡧ ᐃ㛫ኚືࡣࡑࢀࡒࢀ5.2㸣࠾
ࡼࡧ7.4%࡛࠶ࡗࡓࠋ
4㸫2㸫7㸬⤫ィฎ⌮
⤖ᯝࡣࡍ࡚ᖹᆒsᶆ‽ㄗᕪ࡛♧ࡋࡓࠋ⾑୰P4⃰ᗘ㸪ᖍ༸⬊ࡢᖹᆒ┤ᚄ࠾ࡼࡧ㯤య
᩿㠃✚ࡢ᥎⛣ࡢẚ㍑ࡣ㸪2 ඖ㓄⨨ศᩓศᯒࢆ⾜࠸㸪యࡢኚࡢ᭷ពᛶࢆㄪ㸪
స⏝ࡀ᭷ព࡛࠶ࡗࡓࡶࡢᑐࡋ࡚㸪Bartlet᳨ᐃࢆ⾜࠸ศᩓࡢᆒ୍ᛶࢆ᳨ᐃࡋࡓᚋ㸪Pos-hoc
᳨ᐃࡋ࡚Sheffeࡢከ⩌ẚ㍑᳨ᐃࢆ⾜ࡗࡓࠋP < 0.05ࡢሙྜࢆ᭷ពᕪ࠶ࡾࡋࡓࠋ⤫ィ ฎ⌮ࡣ⤫ィฎ⌮ࢯࣇࢺ࡛࠶ࡿStatView㸦Abacus Concepts㸪Inc.㸪Berkeley㸪CA㸪USA㸧
ࢆ⏝࠸ࡓࠋ
4㸫3㸬ヨ㦂 2㸸W1DF 㯤యࡢඹᏑ࠾ࡼࡧ㠀ඹᏑ㛵ಀࡀேᕤᤵ⢭ᚋࡢཷ⫾⋡ཬࡰࡍᙳ
㡪
4㸫3㸫1㸬౪ヨື≀
ᖏᗈ␆⏘Ꮫ␆⏘ࣇ࣮ࣝࢻ⛉Ꮫࢭࣥࢱ࣮࡚㣫㣴ࡉࢀ࡚࠸ࡿ㸪⮫ᗋⓗᗣ࡛Ⓨ
࿘ᮇࡀṇᖖ࡞࣍ࣝࢫࢱࣥ✀⤒⏘Ἢங∵㸦153㢌㸧ᮍ⤒⏘∵㸦75㢌㸧ࢆ⏝࠸ࡓࠋヨ㦂 ᮇ㛫ࡣ2008ᖺ3᭶㹼2013ᖺ9᭶࡛࠶ࡿࠋ౪ヨࡋࡓಶయࡣ㸪ศፔᚋ௦ㅰᛶᝈࡸ⦾Ṫ 㞀ᐖ࡛⒪Ṕࡢ࠶ࡿಶయࢆ㝖࠸ࡓࠋゎᯒࡣ㸪ᘏ238㢌ࡢἪங∵㹙ᖹᆒศፔᚋ᪥ᩘ㸸 119.8 r 5.2᪥㸪ᖹᆒ⏘ḟ㸸2.2 r 0.1㸪ᖹᆒἪங㔞㸸33.9 r 0.5 kg/᪥㸪ᖹᆒ࣎ࢹ࣭ࢥࣥࢹ
81
ࢩ࣭ࣙࣥࢫࢥ㸦BCS㸧㸸2.91 r 0.02㸪ᖹᆒయ㔜㸸637.4 r 4.6 kg; ᖹᆒ r ᶆ‽ㄗᕪ㹛࠾
ࡼࡧᘏ112㢌ࡢᮍ⤒⏘∵㸦ᖹᆒ᭶㱋㸸14.2 r 0.3ࣨ᭶㱋㸪ᖹᆒయ㔜㸸440.6 r 5.0 kg)ࢆ౪ ヨࡋࡓࠋἪங∵࠾ࡼࡧᮍ⤒⏘∵ࡣࢥ࣮ࣥࢧ࣮ࣞࢪ㸪ࢢࣛࢫࢧ࣮ࣞࢪ㸪㇋⢑㸪ࢺ࢘
ࣔࣟࢥࢩ✐⢏࠾ࡼࡧ㓄ྜ㣫ᩱࢆΰྜࡋࡓ TMR ࢆ⤥ࡉࢀ࡚࠾ࡾ㸪⮬⏤㣧Ỉ࡛ࡁࡿࣇࣜ
࣮ࢫࢺ࣮࡚ࣝ㣫㣴ࡉࢀ࡚࠸ࡓࠋࡲࡓ㸪Ἢங∵ࡣ1᪥2ᅇᦢஙࡉࢀ࡚࠸ࡓࠋேᕤᤵ⢭ࡣ㸪 Ἢங∵࠾࠸࡚ࡣศፔᚋ60᪥ࡽ㸪ᮍ⤒⏘∵࠾࠸࡚ࡣయ㔜ࡀ350௨ୖ࡞ࡗࡓⅬ
ࡽ㛤ጞࡉࢀࡓࠋ
4㸫3㸫2㸬ᐇ㦂᪉ἲ
እ㒊Ⓨᚩೃ㸪ࢸ࣮ࣝ࣌ࣥࢺᾘኻࡢ᭷↓㸪⭐㙾᳨ᰝ࠾ࡼࡧ┤⭠᳨ᰝࡼࡿ༸๓༸
⬊ࡢᏑᅾࡸ㏥⾜㯤యࡢ☜ㄆࡼࡿ⮬↛ⓎⓎぢᚋேᕤᤵ⢭ࢆᐇࡋࡓࠋேᕤᤵ⢭ᐇ
24㛫ᚋ┤⭠᳨ᰝࡲࡓࡣ㉸㡢Ἴ⏬ീデ᩿⨨ࢆ⏝࠸࡚༸ࡢ☜ㄆࢆ⾜ࡗࡓࠋ༸ࡋ࡚
࠸࡞࠸ሙྜ㸪ᗘேᕤᤵ⢭ࢆᐇࡋ㸪24㛫ᚋᗘ༸☜ㄆࢆ⾜ࡗࡓࠋࡇࡢ㸪2ᅇ ࡢேᕤᤵ⢭ᐇᚋ㸪༸ࡋ࡚࠸࡞ࡗࡓಶయࡣヨ㦂ࡼࡾ㝖እࡋࡓࠋ༸☜ㄆ᪥ࢆDay 0
ࡋ㸪Day 4ࡽ8ࡢ㛫┤⭠᳨ᰝࢆ⾜࠸㸪W1DF࠾ࡼࡧ㯤యࡢ⨨㛵ಀࢆ㉸㡢Ἴ⏬ീ
デ᩿⨨ࢆ⏝࠸࡚☜ㄆࡋࡓࠋࡇࡢᖍ༸⬊ࡀ2ࡘ࠶ࡿಶయ㸪ࡲࡓࡣᖍ༸⬊ࡀ☜ㄆࡉ
ࢀ࡞࠸ಶయࡣヨ㦂ࡼࡾ㝖እࡋࡓࠋேᕤᤵ⢭ᚋ40᪥┠㉸㡢Ἴ⏬ീデ᩿⨨ࢆ⏝࠸࡚ዷፎ デ᩿ࢆ⾜࠸㸪ཷ⫾⋡ࢆ⟬ฟࡋࡓࠋ
4㸫3㸫3㸬 ༸ᕢࡢほᐹ
W1DF 㯤యࡢඹᏑ࣭㠀ඹᏑ㛵ಀࡢほᐹࡣ㸪5.0MHz ࡢࣜࢽࣉ࣮ࣟࣈࡀᒓࡋࡓ
⤒┤⭠㉸㡢Ἴ⏬ീデ᩿⨨㸦HS̺101V㸪ᮏከ㟁Ꮚ㸪ឡ▱㸧ࢆ⏝࠸ࡓࠋ༸ᕢほᐹ᭱
┤ᚄࢆ᭷ࡍࡿ༸⬊ࢆW1DFࡋ㸪W1DF ࡀྠ୍༸ᕢෆ㯤యඹᏑࡍࡿሙྜࢆඹᏑ⩌㸪
82
㯤యࡀᏑᅾࡍࡿ༸ᕢࡣᑐഃࡢ༸ᕢᏑᅾࡍࡿሙྜࢆ㠀ඹᏑ⩌ࡋࡓࠋ
4㸫3㸫4㸬ཷ⫾⋡ࡢ⟬ฟ
ேᕤᤵ⢭ࡋࡓᘏ㢌ᩘᑐࡍࡿ㸪ࡑࡢேᕤᤵ⢭࡛ዷፎࡋࡓ㢌ᩘࡢྜࡋ࡚㸪ཷ⫾⋡
ࢆ⟬ฟࡋࡓࠋ
4㸫3㸫5㸬⤫ィฎ⌮
ཷ⫾⋡ࡢホ౯ࡣȮ᳨ᐃ࠾ࡼࡧࣟࢪࢫࢸࢵࢡᅇᖐศᯒࢆ⏝࠸ࡓࠋ࡚ࡢ࢘ࢩ
ᑐࡍࡿཷ⫾⋡ࡢホ౯ࡣȮ᳨ᐃࢆ⏝࠸ࡓࠋ⤒⏘Ἢங∵ᮍ⤒⏘∵ࡢཷ⫾⋡ཬࡰࡍ ᙳ㡪ࢆヲ⣽ホ౯ࡍࡿࡓࡵ㸪ࣟࢪࢫࢸࢵࢡᅇᖐศᯒࢆ⏝࠸ࡓࠋ⤒⏘∵ᮍ⤒⏘∵
ࡶཷ⫾⋡ࢆᚑᒓኚᩘࡋࡓࠋ⤒⏘∵ᮍ⤒⏘∵ඹ㏻ࡢ⊂❧ኚᩘࡣ㸪ྠ୍༸ᕢෆ࡛
ࡢ㯤యW1DFࡢඹᏑࡢ᭷↓㸦ඹᏑ㸪㠀ඹᏑ㸧㸪Ꮨ⠇㸦 ᬮ㸸6㹼9᭶㸪෭ᾴ㸸10㹼5᭶㸧
࡛࠶ࡿࠋຍ࠼࡚㸪ᮍ⤒⏘∵࡛ࡣయ㔜㸦㸺441kg㸪Ӎ441kg㸧ࢆ⊂❧ኚᩘࡋ࡚㸪ࣟࢪࢫࢸ
ࢵࢡᅇᖐศᯒࢆ⾜ࡗࡓࠋ⤒⏘Ἢங∵࡛ࡣศፔᚋ᪥ᩘ㸦㸺120᪥㸪Ӎ120᪥㸧㸪Ἢங㔞㸦㸺 34kg/᪥㸪Ӎ34kg/᪥㸧㸪⏘ḟ㸦1㸪2㸪Ӎ3㸧㸪࣎ࢹ࣭ࢥࣥࢹࢩ࣭ࣙࣥࢫࢥ㸦BCS㸹㸺3㸪 Ӎ3㸧㸦27㸧࠾ࡼࡧయ㔜㸦㸺637kg㸪Ӎ637kg㸧ࢆ⊂❧ኚᩘ㏣ຍࡋ࡚ࣟࢪࢫࢸࢵࢡᅇᖐ ศᯒࢆ⾜ࡗࡓࠋἪங㔞ࡣ᭶1ᅇ⾜ࢃࢀࡿ∵⩌᳨ᐃࡢࢹ࣮ࢱࢆ⏝ࡋ㸪BCS࠾ࡼࡧయ㔜ࡣ
␆⏘ࣇ࣮ࣝࢻ⛉Ꮫࢭࣥࢱ࣮࡛ẖ᭶⾜ࢃࢀࡿ ᐃ࡛ᚓࡽࢀࡓࡶࡢࡢ࠺ࡕ㸪ேᕤᤵ⢭ࡽ
┤㏆࡛ᚓࡽࢀࡓࢹ࣮ࢱࢆ⏝ࡋࡓࠋἪங㔞㸪BCS࠾ࡼࡧయ㔜ࡣṇつศᕸᚑࡗ࡚࠸ࡓࡓ
ࡵ㸪ᖹᆒ್࡛2⩌ศࡅࢡࣛࢫศࡅࢆ⾜ࡗࡓࠋP < 0.05ࢆ᭷ពᕪ࠶ࡾࡋࡓࠋ࡚ࡢ᳨
ᐃࡣRࢯࣇࢺ࢙࢘㸦version 2.14.0 for Mac OS X.㸧ࢆ⏝࠸ࡓࠋ
4㸫4㸬⤖ᯝ
83
4㸫4㸫1㸬ヨ㦂1⤖ᯝ
ᮏヨ㦂࡛ඹᏑ⩌ࡣn㸻16㸦ᖹᆒศፔᚋ᪥ᩘ㸸104.8s10.5㸪ᖹᆒ⏘ḟ㸸1.9s0.2㸪ᖹᆒἪ ங㔞㸸35.5s2.1 kg/᪥㸧㸪㠀ඹᏑ⩌ࡣn㸻14㸦ᖹᆒศፔᚋ᪥ᩘ㸸94.4s12.4㸪ᖹᆒ⏘ḟ㸸2.6 s0.4㸪ᖹᆒἪங㔞㸸39.9s2.3 kg/᪥㸧࡛࠶ࡗࡓࠋ㯤యࡢ᩿㠃✚ࡢ᥎⛣ࢆFig. 4.1.♧ࡋࡓࠋ ඹᏑ⩌㠀ඹᏑ⩌㛫࡛㯤య᩿㠃✚ࡢ᥎⛣ᕪࡣ࡞ࡗࡓࠋᖍ༸⬊ࡢᖹᆒ┤ᚄࡢ᥎⛣ࢆ
Fig. 4.2.♧ࡋࡓࠋDay 8࡛ඹᏑ⩌ࡣ㠀ඹᏑ⩌ẚ㍑ࡋ࡚᭷ពࡁࡃⓎ⫱ࡋ࡚࠸ࡓࠋࡲ
ࡓ㸪ࡑࢀࡒࢀࡢ⩌ෆ࡛ࡢ᥎⛣ࢆẚ㍑ࡋࡓࡇࢁ㸪ඹᏑ⩌࡛ࡣDay 4ࡽ6࠾ࡼࡧ8
ࡅ࡚᭷ពࡁࡃⓎ⫱ࡋࡓࡀ㸪㠀ඹᏑ⩌࡛ࡣDay 4ࡽ8ࡅ࡚ࡣࡌࡵ࡚᭷ពࡁ ࡃⓎ⫱ࡋࡓࠋඹᏑ⩌㠀ඹᏑ⩌࡛⾑୰P4⃰ᗘࡢ᥎⛣ࢆẚ㍑ࡋࡓࡇࢁ㸪ᕪࡣࡳࡽࢀ࡞
ࡗࡓ㸦Fig. 4.3㸧ࠋ
4㸫4㸫2㸬ヨ㦂2⤖ᯝ
ᮏヨ㦂࡛㸪౪ヨ∵࡚ࡢ⥲ཷ⫾⋡ࡣ 54.0㸣㸦189/350㸧㸪⤒⏘∵࡛ࡢ⥲ཷ⫾⋡ࡣ 48.9㸣 㸦122/238㸧㸪ᮍ⤒⏘∵࡛ࡢ⥲ཷ⫾⋡ࡣ58.9㸣㸦67/112㸧࡛࠶ࡗࡓࠋ
ᮏヨ㦂࡛⤒⏘∵ᮍ⤒⏘∵ࢆྜࢃࡏࡓࡁࡢඹᏑ⩌ࡣ n㸻184㸪㠀ඹᏑ⩌ࡣn㸻166 ࡛
࠶ࡗࡓࠋ⤒⏘∵࠾ࡅࡿඹᏑ⩌ࡣ n㸻129㸦ᖹᆒศፔᚋ᪥ᩘ㸸115.4s5.7㸪ᖹᆒ⏘ḟ㸸2.4 s0.1㸪ᖹᆒἪங㔞㸸34.9s0.7 kg/᪥㸪ᖹᆒయ㔜㸸646.7s6.3 kg㸪ᖹᆒBCS㸸2.91s0.03㸧㸪 㠀ඹᏑ⩌ࡣn㸻109㸦ᖹᆒศፔᚋ᪥ᩘ㸸118.3s5.6㸪ᖹᆒ⏘ḟ㸸2.1s0.1㸪ᖹᆒἪங㔞㸸32.7 s0.7 kg/᪥㸪ᖹᆒయ㔜㸸626.6s6.5 kg㸪ᖹᆒBCS㸸2.92s0.03㸧࡛࠶ࡾ㸪ᮍ⤒⏘∵࠾ࡅ
ࡿඹᏑ⩌ࡣn㸻55㸦ᖹᆒయ㔜㸸434.1s6.3 kg㸪ᖹᆒ᭶㱋㸸14.1s0.6㸧㸪㠀ඹᏑ⩌࡛ࡣn㸻 57㸦ᖹᆒయ㔜㸸446.9s8.0 kg㸪ᖹᆒ᭶㱋㸸14.2s0.5㸧࡛࠶ࡗࡓࠋ
⤒⏘∵࠾ࡼࡧᮍ⤒⏘∵ࢆྜࢃࡏ㸪ඹᏑ⩌㠀ඹᏑ⩌࡛ཷ⫾⋡ࢆẚ㍑ࡋࡓࡇࢁ㸪ඹᏑ⩌
࡛᭷ពప࠸ཷ⫾⋡࡛࠶ࡗࡓ㹙ඹᏑ⩌ vs. 㠀ඹᏑ⩌㸻40.2㸣㸦74/184㸧 vs. 69.3㸣 㸦115/166㸧㸹Fig. 4.4.㹛ࠋࡲࡓ㸪⤒⏘∵ᮍ⤒⏘∵࡛ࡑࢀࡒࢀඹᏑ⩌㠀ඹᏑ⩌ࡢཷ⫾⋡ࢆ
84
ẚ㍑ࡋࡓࡇࢁ㸪⤒⏘∵ᮍ⤒⏘∵ࡶඹᏑ⩌࡛ప࠸ཷ⫾⋡࡛࠶ࡗࡓ㹙⤒⏘∵㸹ඹᏑ⩌
vs. 㠀ඹᏑ⩌㸻38.0㸣㸦49/129㸧 vs. 67.0㸣㸦73/109㸧㸪ᮍ⤒⏘∵㸹ඹᏑ⩌ vs. 㠀ඹᏑ⩌㸻45.5㸣 㸦25/55㸧 vs. 73.7㸣㸦42/57㸧㹛ࠋࡲࡓ㸪ࣟࢪࢫࢸࢵࢡᅇᖐศᯒࡢ⤖ᯝࡽ㸪ᮏヨ㦂࡛ࡣ㸪 Ꮨ⠇㸪య㔜㸪ศፔᚋ᪥ᩘ㸪ங㔞㸪BCS࠾ࡼࡧ⏘ḟࡣཷ⫾⋡ᙳ㡪ࢆཬࡰࡉ࡞࠸ࡇࡀ᫂ࡽ
࡞ࡗࡓࠋ
4㸫5㸬⪃ᐹ
ヨ㦂1࠾࠸࡚⤒⏘Ἢங∵ࢆ⏝࠸࡚㸪W1DF㯤యࡀྠ୍༸ᕢෆᏑᅾࡍࡿඹᏑ㛵ಀ ࡢሙྜ㸪ࡑࢀࡒࢀࡀᕥྑࡢ␗࡞ࡿ༸ᕢᏑᅾࡍࡿ㠀ඹᏑ㛵ಀࡢሙྜࡘ࠸࡚W1DF 㯤యࡢⓎ⫱ືែ࠾ࡼࡧ⾑୰ P4⃰ᗘ᥎⛣ࢆẚ㍑ࡋࡓࠋࡑࡢ⤖ᯝ㸪㯤యࡢⓎ⫱ືែ⾑୰
P4⃰ᗘືែᕪࡣࡳࡽࢀ࡞ࡗࡓࡀ㸪ඹᏑ⩌ࡢW1DFࡣࡁࡃⓎ⫱ࡍࡿࡇࡀ᫂ࡽ
࡞ࡗࡓࠋࡲࡓ㸪⤒⏘Ἢங∵࠾ࡼࡧᮍ⤒⏘∵ࢆ⏝࠸࡚㸪ேᕤᤵ⢭ᚋࡢཷ⫾⋡ࢆඹᏑ⩌㠀 ඹᏑ⩌࡛ẚ㍑ࡋࡓࡇࢁ㸪ඹᏑ⩌࡛పୗࡍࡿࡇࢆ᫂ࡽࡋࡓࠋ
➨3❶࡛ࡣ㸪㠀Ἢங∵ࢆ⏝࠸࡚Day 6࠾ࡅࡿW1DFࡢᖹᆒ┤ᚄ⾑୰P4⃰ᗘࡘ࠸
࡚ඹᏑ⩌㠀ඹᏑ⩌࡛ẚ㍑ࡋࡓࡇࢁ㸪ඹᏑ⩌࡛ᖹᆒ┤ᚄࡣࡁࡃ㸪⾑୰P4⃰ᗘࡣప࠸
࠸࠺⤖ᯝࢆᚓࡽࢀࡓࠋἪங∵ࢆ⏝࠸ࡓᮏヨ㦂࡛ࡣ⾑୰P4⃰ᗘᕪࡣ࡞ࡗࡓࡀ㸪W1DF ࡢᖹᆒ┤ᚄࡣඹᏑ⩌࡛ࡁࡃ࡞ࡾ㸪ᖹᆒ┤ᚄ㛵ࡋ࡚ࡣྠᵝࡢ⤖ᯝࡀᚓࡽࢀࡓࠋࡉࡽ㸪 㯤యࡢᖹᆒ┤ᚄᕪࡣ࡞ࡃ㸪➨3❶ࡢヨ㦂2ྠᵝࡢ⤖ᯝࡀᚓࡽࢀࡓࠋࡇࢀࡲ࡛㸪㧗Ἢ ங∵ࡢ⾑୰P4⃰ᗘࡣᮍ⤒⏘∵ẚ࡚పࡃ࡞ࡿ㸦78㸧ࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿࡀ㸪୍᪉࡛㸪 㠀Ἢங∵Ἢங∵ࡢⓎ࿘ᮇ୰ࡢ⾑୰P4⃰ᗘ᥎⛣ࢆẚ㍑ࡋࡓࡇࢁ㸪Ἢங∵࡛㯤యᮇ୰
ᮇ࠾࠸࡚㧗ࡃ᥎⛣ࡍࡿ㸦23㸧࠸࠺ሗ࿌ࡶ࠶ࡾ㸪ࡇࡢࡇࡣἪங∵ࡢங⏕⏘క࠺⫢
⮚࡛ࡢࢫࢸࣟࢻ௦ㅰࡢ㐪࠸㸦100㸧ࡸ༸๓༸⬊ࡢࢧࢬࡀ␗࡞ࡿࡇ࡛ᙧᡂࡉࢀࡿ㯤 యࡢࢧࢬࡀࡁࡃ࡞ࡿࡇ㸦23㸪97㸧⏤᮶ࡍࡿ⪃࠼ࡽࢀ࡚࠸ࡿࠋᮏヨ㦂࡛ࡣඹᏑ
⩌㸪㠀ඹᏑ⩌ࡶᵝࠎ࡞ங㔞ࢆᣢࡗࡓἪங∵ࡀヨ㦂౪ヨࡉࢀࡓࡓࡵ㸪⾑୰P4⃰ᗘ
85
㛵ࡋ࡚➨3❶ࡢヨ㦂1␗࡞ࡿ⤖ᯝࡀᚓࡽࢀࡓࡢ࡛ࡣ࡞࠸᥎ ࡉࢀࡿࠋࡋࡋ㸪ୖ
グ࡛㏙ࡓࡼ࠺ᮏヨ㦂࡛ࡣ㸪ඹᏑ⩌㠀ඹᏑ⩌㛫࡛⾑୰P4⃰ᗘᕪࡣ࡞࠸ࡶ㛵ࢃࡽ
ࡎW1DFࡢᖹᆒ┤ᚄࡀඹᏑ⩌࡛ࡁࡃⓎ⫱ࡋࡓࠋᮍ⤒⏘∵ࢆ⏝࠸ࡓヨ㦂࠾࠸࡚㸪W1DF ࡢࢧࢬࡣ㯤యྠ୍༸ᕢෆඹᏑࡍࡿሙྜඹᏑࡋ࡞࠸ሙྜ࡛ᕪࡣ࡞࠸࠸࠺ሗ࿌
㸦40㸧ࡀᏑᅾࡍࡿࠋࡋࡋ㸪ඹᏑ⩌࡛ࡁࡃⓎ⫱ࡍࡿ㸦42㸧࠸࠺ሗ࿌ࡶᏑᅾࡋ㸪ᮏヨ 㦂࡛ࡣᚋ⪅ࡢ⤖ᯝ୍⮴ࡍࡿ⤖ᯝ࡞ࡗࡓࠋ➨3❶ࡢヨ㦂2࡛ࡣ㸪Day 4ࡲ࡛ࡢᖍ༸
⬊ࡢᖹᆒ┤ᚄࡢ᥎⛣ඹᏑ⩌㠀ඹᏑ⩌࡛᭷ព࡞ᕪࡣ࡞࠸࠸࠺⤖ᯝࡀ♧ࡉࢀ㸪ᮏヨ㦂 1 ࡛ᚓࡽࢀࡓ⤖ᯝ▩┪ࡍࡿ⤖ᯝ࡛࠶ࡿࠋࡋࡋᮏヨ㦂࡛ࡢᖍ༸⬊ࡢᖹᆒ┤ᚄࡢ᥎⛣
ࢆࡳࡿDay 4ࡲ࡛ࡣ୧⩌㛫࡛ᕪࡀ࡞࠸ࡇࡽ㸪➨3❶ࡢヨ㦂2࠾࠸࡚ࡶDay 6௨ 㝆࠾࠸࡚ඹᏑ⩌࡛ࡁࡃⓎ⫱ࡋࡓྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋᐇ㸪➨3❶ࡢヨ㦂1࡛Day 8
࠾࠸࡚ඹᏑ⩌࡛ࡢW1DFࡢᖹᆒ┤ᚄࡀࡁࡗࡓࡇࡽࡶࡇࡢ௬ㄝࡣࡅࡽࢀࡿࠋ ᮏヨ㦂࡛ࡣ㸪ඹᏑ⩌㠀ඹᏑ⩌ࡢ㛫࡛⾑୰P4⃰ᗘᕪࡣ࡞࠸ࡶ㛵ࢃࡽࡎ㸪W1DFࡢ ᖹᆒ┤ᚄᕪࡀ⏕ࡌࡓࡇࡽ㸪W1DFࡢ┤ᚄࡢᕪ␗ࡣ⾑୰P4⃰ᗘ࡛ࡣ࡞ࡃ㸪㯤యࡢ
⨨㛵ಀ㉳ᅉࡍࡿࡇࡀ᥎ ࡉࢀࡿࠋ࣮࢝ࣛࢻࣉࣛ⏬ീデ᩿⨨ࢆ⏝࠸ࡓ㐣ཤࡢヨ㦂
࡛ࡣ㸪㯤యW1DFࡀྠ୍༸ᕢෆ࡛Ⓨ⫱ࡋ࡚࠸ࡿሙྜ㸪༸ᕢࡢ⾑⟶ᢠ್ࡀపࡃ㸪༸⬊
ቨ⾑ὶࡀࡁ࠸ࡇࢆሗ࿌ࡋ࡚࠸ࡿ㸦42㸧ࠋ༸⬊ቨ⾑ὶࡣ㸪㑅ᢤࡉࢀࡿ༸⬊ࡸ㛢㙐ࡋ࡚࠸
ࡃ༸⬊ࢆホ౯ࡍࡿᣦᶆࡋ࡚⏝࠸ࡽࢀ࡚࠾ࡾ㸦2㸪42㸧㸪ࡲࡓ㸪༸๓༸⬊ࡢ༸⬊ቨ⾑ὶ
㸪ࡑࡢᚋࡢཷ⫾ᛶ㸦84㸧ࡸయእཷ⢭ᚋࡢ⬇ࡢⓎ⫱⋡㸦86㸧ࡣṇࡢ㛵ಀࡀᏑᅾࡍࡿࡇ
ࡽ㸪༸⬊ቨ⾑ὶࡣ༸⬊ࡢάຊࢆホ౯ࡍࡿᣦᶆࡉࢀ࡚࠸ࡿࠋᮏヨ㦂࠾࠸࡚ࡶ㸪ඹ Ꮡ⩌ࡢW1DFࡢ༸⬊ቨ⾑ὶࡀࡁࡗࡓࡇࡀ᥎ ࡉࢀ㸪ඹᏑ⩌ࡢW1DF㓟⣲㸪ᰤ㣴 ࡉࡽࡣ࣍ࣝࣔࣥࡀࡼࡾከࡃ౪⤥ࡉࢀࡿ㸦109㸧ࡇ࡛㸪Ⓨ⫱ࡀࡁࡃ࡞ࡗࡓ᥎ᐹࡉࢀ
ࡿࠋࡇࡢࡇࡣ㸪W1DF ࡢⓎ⫱ࡸᛶ㉁ཬࡰࡍせᅉࡋ࡚㸪㯤యྠ୍༸ᕢෆ࡛Ⓨ⫱ࡍ
ࡿྰ࠸࠺⨨ⓗ≧ἣࡢᙳ㡪ࡀᏑᅾࡍࡿࡇࢆ♧၀ࡋ࡚࠸ࡿࠋ
㐣ཤࡢሗ࿌࠾࠸࡚㸪W1DFࡢⓎ⫱ືែࡸࡑࢀక࠺࣍ࣝࣔࣥືែࡣヲ⣽ㄪࡽࢀ
86
࡚ࡁࡓࠋࡋࡋ࡞ࡀࡽ㸪W1DFࡀ⦾Ṫ⏕⌮㸪≉ཷ⫾ᛶཬࡰࡍᙳ㡪㛵ࡋ࡚ࡣ༑ศ
ㄪᰝࡉࢀ࡚ࡇ࡞ࡗࡓࠋ➨3❶ࡢヨ㦂1㸪2࠾ࡼࡧᮏ❶ࡢヨ㦂1ࡽ㸪W1DFࡢᛶ㉁ࡣ㯤 యྠ୍༸ᕢෆ࡛ඹᏑࡍࡿྰ࠸࠺ࡇ࡛␗࡞ࡿࡇࡀ᥎ ࡉࢀࡿࠋࡇࢀࡲ࡛㸪㯤 యࡀᏑᅾࡍࡿ༸ᕢྠഃࡢᏊᐑゅ࠾ࡅࡿᏊᐑෆ⭷࡛ࡣ㸪ᑐഃࡢᏊᐑゅ࠾ࡅࡿᏊᐑ ෆ⭷ẚ⤌⧊୰ P4⃰ᗘࡀ㧗࠸ࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸦20㸧ࠋࡲࡓ㸪༸๓༸⬊ࡀᏑᅾ ࡍࡿ༸ᕢྠഃࡢ༸⟶ෆE2⃰ᗘࡣ㸪ᑐഃࡢࡶࡢẚ㍑ࡋ࡚㧗࠸ࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ
㸦99㸧ࠋ࢘ࢩ࡛ࡣ㸪㯤యࡀᙧᡂࡉࢀ࡚࠸ࡿഃྠഃࡢᏊᐑゅ࡛╔ᗋ㸪ዷፎࡋࡸࡍ࠸ࡇࡀ
▱ࡽࢀ࡚࠸ࡿ㸦91㸧ࠋࡇࢀࡽࡢᐇࡽ㸪༸ᕢྠഃࡢᏊᐑゅࡣᐦ᥋࡞ᒁᡤࡢࡘ࡞ࡀࡾ
ࡀᏑᅾࡍࡿࡇࡀ♧၀ࡉࢀࡿࠋࣈࢱࢆ⏝࠸ࡓሗ࿌࠾࠸࡚㸪༸⟶ྥ࠺⾑⟶ࡢ⾑୰P4㸪 A4࠾ࡼࡧE2⃰ᗘࡣᮎᲈ⾑୰ࡢ⃰ᗘẚ㍑ࡋ࡚㧗࠸ࡇࡽ㸪༸ᕢ㟼⬦ࡽᏊᐑࡸ༸⟶
⾑ᾮࢆ౪⤥ࡍࡿ⾑⟶㐃⤖ࡋ࡚࠸ࡿ༸ᕢື⬦ᛶࢫࢸࣟࢻ࣍ࣝࣔࣥࡀᑐྥὶࡼ
ࡾ⛣⾜ࡋ࡚࠸ࡿࡇࡀ᥎ ࡉࢀ࡚࠸ࡿ㸦47㸧ࠋヨ㦂2࠾࠸࡚㸪ேᕤᤵ⢭ᚋࡢཷ⫾⋡ࡣ⤒
⏘∵ᮍ⤒⏘∵ඹඹᏑ⩌࡛పୗࡍࡿࡇࢆ♧ࡋࡓࠋࡲࡓ㸪ங㔞㸪⏘ḟ㸪ศፔᚋ᪥ᩘ㸪 య㔜㛵ࢃࡽࡎ㸪ඹᏑ⩌࡛ཷ⫾ᛶࡀప࠸ࡇࡽ㸪ཷ⫾ᛶࢆỴᐃࡍࡿᅉᏊࡋ࡚W1DF
㯤య࡛ࡢ⨨㛵ಀࡀࡁࡃᙳ㡪ࢆ࠼࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋⓎ࿘ᮇ୰ࡢ⾑୰
E2⃰ᗘࢆ ᐃࡋࡓࡇࢁ㸪➨1༸⬊ἼࡀⓎ⫱ࡍࡿᮇ㛫⾑୰E2⃰ᗘࡀୖ᪼ࡍࡿࡇࡀሗ
࿌ࡉࢀ࡚࠸ࡿࡇࡽ㸪W1DF ࡣ⾑୰E2⃰ᗘࢆୖ᪼ࡉࡏࡿ༑ศ࡞E2ࢆ⏘⏕ࡋ࡚࠸ࡿ
ࡇࡀ࠺ࡀ࠼ࡿ㸦79㸧ࠋࡑࡢࡓࡵ㸪W1DF ࡀᏑᅾࡍࡿ༸ᕢྠഃࡢ༸⟶ࡸᏊᐑゅ࡛ࡣ E2⃰ᗘࡀ㧗ࡃ࡞ࡿ᥎ ࡉࢀࡿࠋ࢘ࢩࡢ༸⟶ୖ⓶⣽⬊ࢆ⏝࠸ࡓin vitroࡢᐇ㦂࠾࠸࡚㸪 E2ࡣ࢚ࢫࢺࣟࢤࣥཷᐜయȘP4ཷᐜయࡢmRNA Ⓨ⌧㔞ࢆୖ᪼ࡉࡏࡿ࠸࠺ሗ࿌ࡀ࠶ࡿ
㸦96㸧ࠋࡲࡓ㸪࢘ࢩࡢᏊᐑෆ⭷⣽⬊ࢆ⏝࠸ࡓin vitroࡢᐇ㦂࠾࠸࡚㸪E2ࡣ࢚ࢫࢺࣟࢤࣥ
ཷᐜయ࠾ࡼࡧP4ཷᐜయⓎ⌧ࢆୖ᪼ࡉࡏࡿ㸦102㸧ࠋࡇࢀࡽࡢࡇࡽ㸪E2ࡣ༸⟶ࡸᏊᐑෆ
⭷ࡢࢫࢸࣟࢻ࣍ࣝࣔࣥཷᐜయࡢⓎ⌧ࢆไᚚࡍࡿࡇࡀ♧၀ࡉࢀࡿࠋ W1DFࡀ㯤యඹ Ꮡࡍࡿሙྜ㸪W1DFࡽ⏘⏕㸪ᨺฟࡉࢀࡿE2ࡀཷ⢭༸ࡸ⬇ࡀᏑᅾࡍࡿྠഃࡢ༸⟶ࡸᏊᐑ
87
ゅᑐࡋ࡚ᒁᡤⓗస⏝ࡋዷፎᡂ❧㛵ࢃࡿᶵ⬟ᙳ㡪ࢆ࠼ࡿࡇ࡛㸪ዷፎᡂ❧ᑐ ࡋ࡚㈇ࡢᙳ㡪ࢆ࠼࡚࠸ࡿࡇࡀ᥎ ࡉࢀࡿࠋࡲࡓ㸪ྠ୍༸ᕢෆᏑᅾࡍࡿW1DFࡀ㯤 యᑐࡋ࡚㸪㯤యᙧᡂࡸP4⏘⏕⬟ࢆᢚไࡍࡿ㸪ࡲࡓࡣ㯤యࡢᏑ⥆ᮇ㛫ࢆ▷ࡃࡍࡿࡇ࡛
ཷ⫾ᛶࡀపୗࡋ࡚࠸ࡿྍ⬟ᛶࡶ⪃࠼ࡽࢀࡿࠋࡋࡋ㸪ᮏ❶ࡢヨ㦂2ࡽ㯤యⓎ⫱ືែࡸ
⾑୰P4⃰ᗘඹᏑ⩌㠀ඹᏑ⩌࡛ᕪࡀࡳࡽࢀ࡞ࡗࡓࡇࡽ㸪ඹᏑࡍࡿW1DFࡼࡿ
㯤యࡢᢚไస⏝ࡢྍ⬟ᛶࡣప࠸⪃࠼ࡽࢀࡿࠋ୍᪉㸪㠀Ἢங⤒⏘∵ࢆ⏝࠸ࡓ➨3❶ࡢ ヨ㦂1࡛ࡣඹᏑ⩌࡛⾑୰P4⃰ᗘࡀపࡗࡓࡇࡸ㸪ᮏヨ㦂࠾࠸࡚ࡶⓎ࿘ᮇయࢆ㏻
ࡋ࡚ࡢ㯤యࡢᏑ⥆ᮇ㛫ࢆㄪᰝࡋ࡚࠸࡞࠸ࡓࡵ㸪ᚋ᭦࡞ࡿ◊✲ࢆ⾜࠺ᚲせࡀ࠶ࡿ⪃࠼
ࡿࠋ
ᮏ❶࡛ࡣ㸪W1DFࡸ㯤యࡢⓎ⫱ືែ࠾ࡼࡧ⾑୰P4⃰ᗘࢆẚ㍑ࡍࡿࡇ࡛㸪㯤యW1DF
ࡀྠ୍༸ᕢෆඹᏑࡲࡓࡣඹᏑࡋ࡞࠸࠸࠺༸ᕢෆ࡛ࡢ⨨㛵ಀࡀ⤒⏘Ἢங∵࠾ࡅ
ࡿW1DFࡢⓎ⫱㛵ࢃࡿせᅉࡋ࡚㔜せ࡛࠶ࡿࡇࢆ♧ࡋࡓࠋࡉࡽ㸪ࡑࡢ⨨㛵ಀࡀ
ཷ⫾ᛶࡲ࡛ࡁࡃᙳ㡪ࢆཬࡰࡍࡇࢆ᫂ࡽࡋ㸪W1DFࡢᛶ㉁࠾ࡼࡧ⦾Ṫ⏕⌮ཬ
ࡰࡍᙳ㡪ࢆ♧ࡋࡓࠋ
4㸫6㸬ᑠᣓ
ᮏ❶࡛ࡣ㸪⤒⏘Ἢங∵ࢆ⏝࠸࡚㸪W1DFࡀ㯤యྠ୍༸ᕢෆ࡛ඹᏑࡋ࡚Ⓨ⫱ࡍࡿሙྜ㸪 W1DFࡢᖹᆒ┤ᚄ᥎⛣ࡀ㠀ඹᏑẚ࡚ࡁࡃⓎ⫱ࡍࡿࡀ㸪㯤యࡢⓎ⫱ືែࡸ⾑୰P4⃰ ᗘࡢ᥎⛣㐪࠸ࡣࡳࡽࢀ࡞࠸ࡇࢆ♧ࡋࡓࠋࡲࡓ㸪ேᕤᤵ⢭ᚋ࠾ࡅࡿW1DFࡀ㯤య
ඹᏑࡍࡿሙྜ㠀ඹᏑࡢሙྜ࡛ࡢࡑࡢᚋࡢཷ⫾⋡ࢆẚ㍑ࡋࡓࡇࢁ㸪ඹᏑ⩌࡛ཷ⫾⋡ࡀ ప࠸ࡇࢆ♧ࡋ㸪W1DFࡢ⦾Ṫ⏕⌮࠼ࡿᙳ㡪ࢆ᫂ࡽࡋࡓࠋ
100 200 300 400 500 600 700
Day2 Day4 Day6 Day8 Day10 IG
CG
G : NS
D : P < 0.001 G,D : NS
Days from follicular wave emergence
Cross-sectional areaof corpus luteum(mm2)
Fig. 4.1.
Comparative changes of corpus luteum (CL) of IG and CG on Day 2, 4, 6, 8, 10. Day 0 = The day of the first follicular wave emergence. Effect of group (G) (NS), day (D) (P < 0.001) and interaction between group and day (G,D) (NS).
IG; Ipsilateral group: Dominant follicle (DF) ipsilateral to the CL. CG;
Contralateral group: DF contralateral to the CL. Values are mean r SEM of each point.
88
6 8 10 12 14 16 18 20
Day2 Day4 Day6 Day8 Day10 IG
CG
G : P < 0.01 D : P < 0.001 G,D : P < 0.01
Days from follicular wave emergence
Diameter of dominant follicle (mm)
Fig. 4.2.
Comparative changes of the first follicular wave dominant follicle (DF) of IG and CG on Day 2, 4, 6, 8, 10. Day 0 = The day of the first follicular wave emergence. Effect of group (G) (P < 0.01), day (D) (P <
0.001) and interaction between group and day (G,D) (P < 0.01). IG;
ipsilateral group: DF ipsilateral to the corpus luteum (CL). CG;
contralateral group: DF contralateral to the CL. The asterisk denotes difference between each point, : P < 0.05. Values are mean r SEM of each point.
89
0 1.0 2.0 3.0 4.0 5.0 6.0 7.0
Day2 Day4 Day6 Day8 Day10 IG
CG
G : NS
D : P < 0.001 G,D : NS
Days from follicular wave emergence
Plasma concentration of P4(ng/ml)
Fig. 4.3.
Comparative changes of plasma P4 concentration of IG and CG on Day 2, 4, 6, 8, 10. Day 0 = The day of the first follicular wave emergence. Effect of group (G) (NS), day (D) (P < 0.001) and interaction between group and day (G,D) (NS). IG; ipsilateral group:
Dominant follicle (DF) ipsilateral to the corpus luteum (CL). CG;
contralateral group: DF contralateral to the CL. Values are mean r SEM of each point.
Plasma P
4concentra tio n (ng/ml)
Days from follicular wave emergence
90
0 10 20 30 40 50 60 70 80
Conception rate (%)
Lactating dairy cows Dairy heifers 38.0%
(49/129)
67.0%
(73/109)
45.5%
(25/55)
73.7%
(42/57) IG
CG
Figure 4.4.
Conception rates in IG and CG. Conception rates were different between IG and CG in both lactating dairy cows and dairy heifers. IG; ipsilateral group: Dominant follicle (DF) ipsilateral to the corpus luteum (CL). CG;
contralateral group: DF contralateral to the CL. The asterisk denotes difference between each point, : P < 0.01.
91
92