➨ 1 ༸⬊Ἴᖍ༸⬊㸦 W1DF 㸧ࡢⓎ⫱ࢆไᚚࡍࡿせᅉ
58
3㸫1㸬ᗎㄽ
➨2❶ࡼࡾ㸪W1DFࡢⓎ⫱ືែ㸪ᶵ⬟㸪༸๓ᚋࡢᛶ㉁࠾ࡼࡧ༸ᚋᙧᡂࡉࢀࡿ㯤 యࡢᛶ㉁ࢆW2DFẚ㍑ࡍࡿࡇ࡛᫂ࡽࡋࡓࠋࡲࡓ㸪୧⪅ࡢᛶ㉁ࡢ㐪࠸ࢆࡶࡓࡽࡍ せᅉࡋ࡚㸪ᮎᲈ⾑୰ࡢ P4⃰ᗘࡢ㐪࠸ࡼࡿ LH ࣃࣝࢫ㢖ᗘࡢ㐪࠸ࡀ᥎ ࡉࢀࡓ㸦15㸪 52㸧ࠋAdams ࡽ㸦5㸧ࡣⓎ┤ᚋࡢ࢘ࢩ⭐ෆ␃⨨ᆺ P4〇ࢆᤄධࡋࡓࡁ㸪W1DF ࡢ
᭱┤ᚄࡀ↓ฎ⨨⩌ẚ㍑ࡋ࡚ᑠࡉ࠸ࡇࢆ♧ࡋ࡚࠸ࡿࠋࡇࡢࡇࡽ㸪W1DFࡢᛶ㉁
ࢆᕥྑࡍࡿせᅉࡋ࡚㸪Ⓨ⫱ᮇ㛫୰ࡢ⾑୰P4⃰ᗘࡼࡿᙳ㡪ࡀ⪃࠼ࡽࢀࡿࠋࡋࡋ࡞ࡀ
ࡽ㸪↓ฎ⨨≧ែ࡛ࡢW1DFࡢⓎ⫱ࢆไᚚࡍࡿせᅉࡣ㸪㐣ཤ࠾࠸࡚༑ศ᫂ࡽࡉࢀ
࡚ࡣ࠸࡞࠸ࠋࡑࡇ࡛㸪ᮏ❶࡛ࡣ༸⬊Ⓨ⫱ᮇ㛫୰ࡢ⾑୰P4⃰ᗘࡀ༸⬊ࡢⓎ⫱ཬࡰࡍᙳ㡪
ࢆㄪࡓࠋࡉࡽ㸪W1DF ࡣ㯤యྠ୍༸ᕢෆ࡛Ⓨ⫱ࡍࡿ㸦ඹᏑ㸧㸪ᑐഃࡢ༸ᕢ࡛
Ⓨ⫱ࡍࡿ㸦㠀ඹᏑ㸧ࡢࡕࡽ࡛࠶ࡿࠋࡇࢀࡲ࡛㸪W1DF㯤యࡢඹᏑࡲࡓࡣ㠀ඹᏑ ࡢⓎ⏕⋡ࡣኚࢃࡽ࡞࠸࠸࠺ሗ࿌ࡀ࠶ࡾ㸦40㸧㸪୍᪉࡛ඹᏑࡢⓎ⏕⋡ࡀ㧗࠸࠸࠺ሗ࿌ࡶ
࠶ࡿ㸦33㸧ࠋࡋࡋ࡞ࡀࡽ㸪W1DF㯤యࡢඹᏑࡲࡓࡣ㠀ඹᏑࡀW1DFࡢⓎ⫱ືែࡸ༸
⬊ࡢᶵ⬟࠼ࡿᙳ㡪ࡣ༑ศࡣ᳨ウࡉࢀ࡚࠸࡞࠸ࠋࡑࡇ࡛㸪ᮏ❶࡛ࡣ㸪༸ᕢෆᒁᡤ⎔
ቃࡀ༸⬊ࡢᛶ㉁ᙳ㡪ࢆ࠼ࡿྍ⬟ᛶࢆ᥈ࡿࡓࡵ㸪ඹᏑ㠀ඹᏑࡢ㛫࡛ࡢW1DFࡢⓎ
⫱ືែ㸪༸⬊ᾮ୰ࢫࢸࣟࢻ࣍ࣝࣔࣥࢆ ᐃࡋ㸪ẚ㍑ࡋࡓࠋ
3㸫2㸬ヨ㦂1㸸༸⬊ἼⓎ⌧ࡽ7 ᪥┠ࡢW1DF ࡢ┤ᚄ⾑୰ P4⃰ᗘࡢ┦㛵㛵ಀ࠾ࡼࡧ W1DF㯤యࡢඹᏑࡲࡓࡣ㠀ඹᏑ㛵ಀࡀW1DFࡢ┤ᚄཬࡰࡍᙳ㡪
3㸫2㸫1㸬౪ヨື≀
59
⮫ᗋⓗᗣ࡛㸪ṇᖖ࡞Ⓨ࿘ᮇࢆ᭷ࡍࡿ࣍ࣝࢫࢱࣥ✀㠀Ἢங∵30㢌㸦ᖹᆒᖺ㱋㸸 6.1 r 0.4 ṓ㸪ᖹᆒ±ᶆ‽ㄗᕪ) ࢆ⏝࠸࡚㸪ᘏ44㢌ࡢࢹ࣮ࢱࢆゎᯒ⏝ࡋࡓࠋ࢘ࢩࡣ ᖏᗈ␆⏘Ꮫ␆⏘ࣇ࣮ࣝࢻ⛉Ꮫࢭࣥࢱ࣮ෆࡢࣃࢻࢵࢡ࡚㸪ࢥ࣮ࣥࢧ࣮ࣞࢪ㸪ⲡ
࠾ࡼࡧ⃰ཌ㣫ᩱࡀΰྜࡉࢀࡓTMRࢆ⤥ࡉࢀ㸪⮬⏤㣧Ỉ࡛ࡁࡿ≧ἣ࡛㣫㣴ࡉࢀ࡚࠸ࡓࠋ ᐇ㦂ෆᐜࡣᖏᗈ␆⏘Ꮫࡢᐇ㦂⌮ጤဨ࡚ᢎㄆࡉࢀ࡚࠸ࡿࠋ
3㸫2㸫2㸬ᐇ㦂᪉ἲ
⮬↛Ⓨ㛤ጞᚋ㸪12㛫ࡈ㉸㡢Ἴ⏬ീデ᩿⨨ࢆ⏝࠸࡚༸ᕢࢆほᐹࡋ㸪༸๓༸
⬊ࡢᾘኻࢆ☜ㄆࡋࡓⅬࢆDay 0ࡋࡓࠋDay 6㉸㡢Ἴ⏬ീデ᩿⨨ࢆ⏝࠸࡚W1DF ࡢほᐹࢆ⾜ࡗࡓࠋࡇࡢ㸪㯤యW1DFࡀྠ୍༸ᕢෆᏑᅾࡍࡿඹᏑ㛵ಀ㸪ࡑࢀࡒࢀ
ࡀูࡢ༸ᕢᏑᅾࡍࡿ㠀ඹᏑ㛵ಀ࡛࠶ࡿࡢࢆ☜ㄆࡋࡓࠋࡲࡓ㸪29㢌ࡽṇ୰ᑿ㟼⬦ࡼ
ࡾ᥇⾑ࢆ⾜ࡗࡓࠋ
3㸫2㸫3㸬 ༸⬊ᙧែࡢほᐹ
ᖍ༸⬊ࡢᖹᆒ┤ᚄࡣ㸪5.0MHzࡢࣜࢽࣉ࣮ࣟࣈࡀᒓࡋࡓ⤒┤⭠㉸㡢Ἴ⏬ീデ᩿
⨨㸦HS̺101V㸪ᮏከ㟁Ꮚ㸪ឡ▱㸧ࢆ⏝࠸࡚ ᐃࡋࡓࠋࣉ࣮ࣟࣈࢆᡭᣦࡶ┤⭠ෆ
ᤄධࡋ㸪ᕥྑ୧ഃ༸ᕢࡢ᩿ᒙീࢆほᐹࡋࡓࠋᖍ༸⬊ࡢ༸⬊᩿ᒙ⏬ീࡀ᭱࡞ࡿࡼ࠺㟼 Ṇ⏬ࢆグ㘓ࡋ㸪ࣃࢯࢥࣥୖ㟼Ṇ⏬ࢆ⛣ືࡉࡏ㸪ᖍ༸⬊ࡣ㛗ᚄ▷ᚄࡢᖹᆒ್ࢆᖹᆒ┤
ᚄࡋ㸪ࢹ࣮ࢱࡋ࡚⏝࠸ࡓࠋ
3㸫2㸫4㸬᥇⾑
21G᥇⾑㔪࣊ࣃࣜࣥຍ┿✵᥇⾑⟶㸦࣋ࣀࢪ࢙ࢡࢺϩ┿✵᥇⾑⟶㸪TERUMO㸪ᮾி㸪᪥
ᮏ㸧ࢆ⏝࠸࡚ᑿ㟼⬦ࡼࡾ10mlࡢ᥇⾑ࢆ⾜ࡗࡓࠋ᥇ྲྀࡋࡓ⾑ᾮࡣịỈ୰࡚ᛴ෭ᚋ㸪4Υ࡛
2,000 g㸪20ศ㛫㐲ᚰࡋ㸪⾑₢ศ㞳ᚋ㸪⾑୰P4⃰ᗘ ᐃࡲ࡛㸫30Υ࡚⤖ಖᏑࡋࡓࠋ
60
3㸫2㸫5㸬⾑୰P4⃰ᗘࡢ ᐃ
Day 6࠾ࡅࡿ⾑୰P4⃰ᗘࡣEIAࡼࡾ ᐃࡋࡓࠋ ᐃࡣ➨2❶ྠᵝࡢ᪉ἲ࡛⾜ࡗࡓࠋ
ᐃෆኚື࠾ࡼࡧ ᐃ㛫ኚືࡣࡑࢀࡒࢀ5.2㸣࠾ࡼࡧ7.4%࡛࠶ࡗࡓࠋ
3㸫2㸫6㸬⤫ィฎ⌮
Day 6࠾ࡅࡿᖍ༸⬊ࡢᖹᆒ┤ᚄ⾑୰P4⃰ᗘࡢ┦㛵ᛶࢆㄪࡿࡓࡵࡣ㸪᭱ᑠ2
ἲࡼࡾᅇᖐ┤⥺ᘧࢆồࡵ㸪Pearsonࡢ┦㛵ಀᩘࢆồࡵ࡚┦㛵ࡢ᭷ពᛶࢆ᳨ᐃࡋࡓࠋ⤖
ᯝࡣࡍ࡚ᖹᆒ್±ᶆ‽ㄗᕪ࡛♧ࡋࡓࠋඹᏑ⩌㠀ඹᏑ⩌ࡢ㛫࡛Day 6࠾ࡅࡿᖍ༸⬊
ࡢᖹᆒ┤ᚄ⾑୰P4⃰ᗘࡢẚ㍑ࡣ㸪F᳨ᐃࢆ⾜࠸ศᩓࡢᆒ୍ᛶࢆ☜ㄆࡋࡓᚋ㸪Student ࡢt᳨ᐃࢆ⏝࠸ࡓࠋP < 0.05ࡢሙྜࢆ᭷ពᕪ࠶ࡾࡋࡓࠋ⤫ィฎ⌮ࡣ⤫ィฎ⌮ࢯࣇࢺ࡛
࠶ࡿStatView㸦Abacus Concepts㸪Inc.㸪Berkeley㸪CA㸪USA㸧ࢆ⏝࠸ࡓࠋ
3㸫3㸬ヨ㦂2㸸W1DF㯤యࡢඹᏑࡲࡓࡣ㠀ඹᏑ㛵ಀࡀ༸⬊ἼⓎ⌧᪥ࡽ5᪥┠ࡲ࡛ࡢ
W1DF㯤యࡢⓎ⫱ືែ㸪⾑୰P4⃰ᗘ㸪࠾ࡼࡧ༸⬊ᾮࢫࢸࣟࢻ࣍ࣝࣔࣥ⃰ᗘ
ཬࡰࡍᙳ㡪
3㸫3㸫1㸬౪ヨື≀
⮫ᗋⓗᗣ࡛㸪ṇᖖ࡞Ⓨ࿘ᮇࢆ᭷ࡍࡿ࣍ࣝࢫࢱࣥ✀㠀Ἢங∵5㢌㸦ᖹᆒᖺ㱋㸸 5.6 r 1.0 ṓ㸪ᖹᆒ±ᶆ‽ㄗᕪ) ࢆ⏝࠸ࡓࠋ࢘ࢩࡣᖏᗈ␆⏘Ꮫ␆⏘ࣇ࣮ࣝࢻ⛉Ꮫࢭࣥࢱ
࣮ෆࡢࣃࢻࢵࢡ࡚㸪ࢥ࣮ࣥࢧ࣮ࣞࢪ㸪ⲡ࠾ࡼࡧ⃰ཌ㣫ᩱࡀΰྜࡉࢀࡓ TMR ࢆ⤥
ࡉࢀ㸪⮬⏤㣧Ỉ࡛ࡁࡿ≧ἣ࡛㣫㣴ࡉࢀ࡚࠸ࡓࠋᐇ㦂ෆᐜࡣᖏᗈ␆⏘Ꮫࡢᐇ㦂⌮ጤ ဨ࡚ᢎㄆࡉࢀ࡚࠸ࡿࠋ
61
3㸫3㸫2㸬ᐇ㦂᪉ἲ
⮬↛Ⓨ㛤ጞᚋ㸪12㛫ࡈ㉸㡢Ἴ⏬ീデ᩿⨨ࢆ⏝࠸࡚༸ᕢࢆほᐹࡋ㸪༸๓༸
⬊ࡢᾘኻࢆ☜ㄆࡋࡓⅬࢆDay 0ࡋࡓࠋDay 0ࡽ4ࡅ࡚㉸㡢Ἴ⏬ീデ᩿⨨ࢆ⏝
࠸࡚W1DF࠾ࡼࡧ㯤యࡢほᐹࢆ⾜ࡗࡓࠋࡲࡓ㸪Day 4ࡢⅬ࡛W1DFࡀ㯤యྠ୍༸ᕢ ෆᏑᅾࡍࡿಶయࢆඹᏑ⩌㸪W1DFࡀ㯤యᑐഃࡢ༸ᕢᏑᅾࡍࡿሙྜࢆ㠀ඹᏑ⩌
ศ㢮ࡋࡓࠋࡲࡓ㸪Day 0ࡽ4ࡅ࡚㐃᪥ṇ୰ᑿ㟼⬦ࡼࡾ᥇⾑ࢆ⾜ࡗࡓࠋࡑࡋ࡚㸪Day 4W1DFࡢ༸⬊ᾮ࠾ࡼࡧ㢛⢏ᒙ⣽⬊ࡢᅇࢆ⤒⭐༸⬊྾ᘬἲࡼࡾ⾜ࡗࡓࠋ
5㢌ࡢ౪ヨ∵ࡣ㸪ࣛࢸࣥ᱁Ꮚἲࡼࡿࢡࣟࢫ࣮࢜ࣂ࣮ヨ㦂ࢆ⾜ࡗࡓࡓࡵ㸪ඹᏑ⩌㸦n㸻
5㸧࠾ࡼࡧ㠀ඹᏑ⩌㸦n㸻5㸧ࡣࡑࢀࡒࢀ5㢌ࡢ౪ヨ∵ࡀ1ᅇࡎࡘྵࡲࢀ࡚࠸ࡿࠋ
3㸫3㸫3㸬༸⬊࠾ࡼࡧ㯤యᙧែࡢほᐹ
ᖍ༸⬊ࡢᖹᆒ┤ᚄ࠾ࡼࡧ㯤యࡢ᩿㠃✚ࡣ㸪5.0MHzࡢࣜࢽࣉ࣮ࣟࣈࡀᒓࡋࡓ⤒┤
⭠㉸㡢Ἴ⏬ീデ᩿⨨㸦HS̺101V㸪ᮏከ㟁Ꮚ㸪ឡ▱㸪᪥ᮏ㸧ࢆ⏝࠸࡚ ᐃࡋࡓࠋࣉ࣮ࣟ
ࣈࢆᡭᣦࡶ┤⭠ෆᤄධࡋ㸪ᕥྑ୧ഃ༸ᕢࡢ᩿ᒙീࢆほᐹࡋࡓࠋᖍ༸⬊ࡢ༸⬊᩿
ᒙ⏬ീࡀ᭱࡞ࡿࡼ࠺㟼Ṇ⏬ࢆグ㘓ࡋ㸪ࣃࢯࢥࣥୖ㟼Ṇ⏬ࢆ⛣ືࡉࡏ㸪ᖍ༸⬊ࡣ㛗 ᚄ▷ᚄࡢᖹᆒ್ࢆᖹᆒ┤ᚄࡋ㸪ࢹ࣮ࢱࡋ࡚⏝࠸ࡓࠋ㯤యࡢ᩿㠃✚ࡣ㸪㯤యࡢ᩿ᒙ⏬
ീࡀ᭱࡞ࡿࡼ࠺㟼Ṇ⏬ࢆグ㘓ࡋࡓࠋࣃࢯࢥࣥୖ㟼Ṇ⏬ࢆ⛣ືࡉࡏ㸪㯤యࡢ㛗ᚄ▷
ᚄࡢᖹᆒ್ࡽᖹᆒ┤ᚄࢆ⟬ฟࡋ㸪㸦ᖹᆒ┤ᚄ㸭2㸧2×3.14ᙜ࡚ࡣࡵ㯤య᩿㠃✚ࢆ⟬ฟࡋ㸪 ࢹ࣮ࢱ⏝࠸ࡓࠋ
3㸫3㸫4㸬᥇⾑
21G᥇⾑㔪࣊ࣃࣜࣥຍ┿✵᥇⾑⟶㸦࣋ࣀࢪ࢙ࢡࢺϩ┿✵᥇⾑⟶㸪TERUMO㸪ᮾி㸪᪥
ᮏ㸧ࢆ⏝࠸࡚ᑿ㟼⬦ࡼࡾ10mlࡢ᥇⾑ࢆ⾜ࡗࡓࠋ᥇ྲྀࡋࡓ⾑ᾮࡣịỈ୰࡚ᛴ෭ᚋ㸪4Υ࡛
62
2,000 g㸪20ศ㛫㐲ᚰࡋ㸪⾑₢ศ㞳ᚋ㸪⾑୰P4࠾ࡼࡧE2⃰ᗘ ᐃࡲ࡛㸫30Υ࡚⤖ಖᏑࡋ ࡓࠋ
3㸫3㸫5㸬ᖍ༸⬊ࡢ྾ᘬ༸⬊ᾮࡢᅇ
ᖍ༸⬊ࡢ྾ᘬ㸪༸⬊ᾮࡢᅇ࠾ࡼࡧࡑࡢᚋࡢฎ⌮ಖᏑࡣ㸪➨2❶ྠᵝࡢ᪉ἲ࡛⾜
ࡗࡓࠋ
3㸫3㸫6㸬༸⬊ᾮP4㸪E2࠾ࡼࡧA4⃰ᗘࡢ ᐃ
༸⬊ᾮࢫࢸࣟࢻ࣍ࣝࣔࣥࡢ ᐃࡣ➨2❶ྠᵝࡢ᪉ἲ࡛⾜ࡗࡓࠋࡇࡢ ᐃἲࡼࡿP4㸪 E2࠾ࡼࡧA4ࡢᢳฟຠ⋡ࡣࡑࢀࡒࢀ85㸣㸪81㸣࠾ࡼࡧ84㸣࡛࠶ࡗࡓࠋP4ࡢ ᐃෆኚື࠾ࡼࡧ ᐃෆኚືࡣࡑࢀࡒࢀ5.5%࠾ࡼࡧ7.4%㸪E2ࡢ ᐃෆኚື࠾ࡼࡧ ᐃ㛫ኚືࡣ6.2㸣࠾ࡼࡧ 8.6%㸪A4ࡢ ᐃෆኚື࠾ࡼࡧ ᐃ㛫ኚືࡣࡑࢀࡒࢀ5.6㸣࠾ࡼࡧ7.8%࡛࠶ࡗࡓࠋ
3㸫3㸫7㸬⾑୰P4࠾ࡼࡧE2⃰ᗘࡢ ᐃ
Day 0ࡽ4࠾ࡅࡿ⾑୰P4⃰ᗘ࠾ࡼࡧDay 4ࡢ⾑୰E2⃰ᗘࡣEIAࡼࡾ ᐃࡋࡓࠋ ᐃ᪉ ἲࡣ➨2❶ྠᵝࡢ᪉ἲ࡛⾜ࡗࡓࠋP4ࡢ ᐃෆኚື࠾ࡼࡧ ᐃ㛫ኚືࡣࡑࢀࡒࢀ5.2㸣࠾ࡼ
ࡧ7.4%㸪E2ࡢ ᐃෆኚື࠾ࡼࡧ ᐃ㛫ኚືࡣࡑࢀࡒࢀ6.0㸣࠾ࡼࡧ8.4㸣࡛࠶ࡗࡓࠋ
3㸫3㸫8㸬⤫ィฎ⌮
⤖ᯝࡣࡍ࡚ᖹᆒ್±ᶆ‽ㄗᕪ࡛♧ࡋࡓࠋ⾑୰ P4⃰ᗘ㸪ᖍ༸⬊ࡢᖹᆒ┤ᚄ࠾ࡼࡧ㯤 య᩿㠃✚ࡢ᥎⛣ࡢẚ㍑ࡣ㸪2 ඖ㓄⨨ศᩓศᯒࢆ⾜࠸యࡢኚࡢ᭷ពᛶࢆㄪ㸪
స⏝ࡀ᭷ព࡛࠶ࡗࡓࡶࡢᑐࡋ࡚㸪Bartlet ᳨ᐃࢆ⾜࠸ศᩓࡢᆒ୍ᛶࢆ᳨ᐃࡋࡓᚋ㸪 Post-hoc᳨ᐃࡋ࡚Schefeࡢከ⩌ẚ㍑᳨ᐃࢆ⾜ࡗࡓࠋDay 4࠾ࡅࡿඹᏑ⩌㠀ඹᏑ⩌
㛫࡛ࡢ⾑୰E2⃰ᗘ࠾ࡼࡧ༸⬊ᾮ୰P4㸪E2࠾ࡼࡧA4⃰ᗘࡢ᳨ᐃࡣF᳨ᐃࡼࡾศᩓࡢ
63
ᆒ୍ᛶࢆ᳨ᐃࡋ㸪Studentࡢt᳨ᐃࢆ⾜ࡗࡓࠋP < 0.05ࡢሙྜࢆ᭷ពᕪ࠶ࡾࡋࡓࠋ⤫ィ ฎ⌮ࡣ⤫ィฎ⌮ࢯࣇࢺ࡛࠶ࡿStatView㸦Abacus Concepts㸪Inc.㸪Berkeley㸪CA㸪USA㸧
ࢆ⏝࠸ࡓࠋ
3㸫4㸬⤖ᯝ
3㸫4㸫1㸬ヨ㦂1⤖ᯝ
ᮏヨ㦂࡛ඹᏑ⩌ࡣn㸻22㸦ᖹᆒᖺ㱋㸸6.2±0.6㸧㸪㠀ඹᏑ⩌ࡣn㸻22㸦ᖹᆒᖺ㱋㸸6.2±0.4㸧
࡛࠶ࡗࡓࠋ᥇⾑ࢆ⾜ࡗࡓ࢘ࢩ㸦n㸻29㸪ᖹᆒᖺ㱋㸸6.1±0.4㸧ࡢ⾑୰P4⃰ᗘࡢᖹᆒ್ࡣ3.0±0.2 ng/ml࡛࠶ࡗࡓࠋࡲࡓ㸪ඹᏑ⩌㸦n㸻16㸪ᖹᆒᖺ㱋㸸6.0±0.7㸧࡛ࡢ⾑୰P4⃰ᗘࡢᖹᆒ್ࡣ 㠀ඹᏑ⩌㸦n㸻13㸪ᖹᆒᖺ㱋㸸6.2±0.6㸧࡛ࡢ⾑୰ P4⃰ᗘࡢᖹᆒ್ẚ࡚㸪᭷ពప
ࡗࡓ㸦Table 3.1.㸧ࠋ
Day 6࠾ࡅࡿ⾑୰P4⃰ᗘᖍ༸⬊┤ᚄࡢ┦㛵㛵ಀࢆㄪࡓ⤖ᯝ㸪᭷ព࡞┦㛵㛵
ಀࡣほᐹࡉࢀ࡞ࡗࡓ㸦Fig. 3.1.㸧ࠋࡲࡓ㸪ඹᏑ⩌㠀ඹᏑ⩌ࢆࡑࢀࡒࢀศࡅ࡚┦㛵㛵ಀ
ࢆㄪࡓሙྜ㸪୧⩌ࡶ⾑୰P4⃰ᗘᖍ༸⬊┤ᚄࡢ㛫᭷ព࡞┦㛵㛵ಀࡣほᐹࡉࢀ
࡞ࡗࡓ㸦Fig. 3.2.㸧ࠋ
ඹᏑ⩌㠀ඹᏑ⩌࡛Day 6࠾ࡅࡿᖍ༸⬊ࡢᖹᆒ┤ᚄࢆẚ㍑ࡋࡓࡇࢁඹᏑ⩌࡛᭷
ពࡁࡗࡓ㸦Table 3.2.㸧ࠋ
3㸫4㸫2㸬ヨ㦂2⤖ᯝ
ඹᏑ⩌㠀ඹᏑ⩌ࡢᖍ༸⬊ࡢᖹᆒ┤ᚄࡢ᥎⛣ࢆFig. 3.3.♧ࡋࡓࠋඹᏑ⩌࡛Day 2
ࡽ4ࡅ࡚㠀ඹᏑ⩌ẚ㍑ࡋ࡚ࡁࡃ᥎⛣ࡋ࡚࠸ࡓࡀ㸪᭷ព࡞ᕪࡣࡳࡽࢀ࡞ࡗࡓࠋ ඹᏑ⩌㠀ඹᏑ⩌ࡢ㯤య᩿㠃✚࠾ࡼࡧ⾑୰P4⃰ᗘ᥎⛣ࢆFig. 3.4.Fig. 3.5.ࡑࢀࡒࢀ♧
ࡋࡓࠋ㯤య᩿㠃✚࠾ࡼࡧ⾑୰P4⃰ᗘ᥎⛣ඹ୧⩌㛫࡛ᕪࡣ࡞ࡗࡓࠋ
64
Day 4࠾ࡅࡿ⾑୰E2⃰ᗘࢆẚ㍑ࡋࡓࡇࢁ㸪ඹᏑ⩌࡛㧗࠸ഴྥࢆ♧ࡋࡓࠋDay 4
࠾ࡅࡿ༸⬊ᾮ୰ࡢᛶࢫࢸࣟࢻ࣍ࣝࣔࣥ⃰ᗘࢆTable 3.4.♧ࡋࡓࠋ༸⬊ᾮE2⃰ᗘ࠾ࡼࡧ A4⃰ᗘᕪࡣࡳࡽࢀ࡞ࡗࡓࡀ㸪༸⬊ᾮP4⃰ᗘࡣඹᏑ⩌࡛᭷ព㧗ࡗࡓࠋ
3㸫5㸬⪃ᐹ
ᮏヨ㦂࠾࠸࡚㸪ヨ㦂1ࡽDay 6ࡢ⾑୰P4⃰ᗘࡣW1DFࡢ┤ᚄᙳ㡪ࢆ࠼࡞࠸ࡇ
ࢆ♧ࡋࡓࡀ㸪W1DF㯤యࡢ༸ᕢෆ࡛ࡢඹᏑࡲࡓࡣ㠀ඹᏑ㛵ಀࡀᖍ༸⬊ࡢ┤ᚄࡸ
⾑୰P4⃰ᗘᙳ㡪ࢆ࠼ࡿࡇࡀ♧ࡉࢀࡓࠋࡉࡽ㸪ヨ㦂2࡛ࡣඹᏑ⩌࠾࠸࡚㸪⾑୰
E2⃰ᗘ࠾ࡼࡧ༸⬊ᾮ୰P4⃰ᗘࡀ㧗್ࢆ♧ࡋࡓࡇࡽ㸪W1DFࡢⓎ⫱ࡸᛶ㉁ࢆไᚚࡍࡿ
せᅉࡋ࡚㸪༸ᕢෆ࡛ࡢ㯤యࡢඹᏑࡲࡓࡣ㠀ඹᏑ≧ែࡀࡁࡃᙳ㡪ࢆཬࡰࡍࡇࡀ᫂
ࡽ࡞ࡗࡓࠋ
➨2❶࠾࠸࡚㸪W1DFW2DFࡢẚ㍑࡛ࡣᖍ༸⬊ࡢⓎ⫱ࡣ⾑୰P4⃰ᗘࡀࡁࡃ 㛵ࡍࡿࡇࢆ♧ࡋࡓࡀ㸪Day 6࠾ࡅࡿW1DFࡢᖹᆒ┤ᚄ⾑୰P4⃰ᗘ┦㛵㛵ಀࡣ
ࡳࡽࢀ࡞ࡗࡓࠋ⮬↛Ⓨᚋࡢ༸☜ㄆ⭐ෆ␃⨨ᆺP4〇ࢆᤄධࡋࡓࡁࡢ㸪༸ᕢ ෆ࡛Ⓨ⫱ࡍࡿW1DFࡢⓎ⫱ືែࢆほᐹࡋࡓ◊✲࡛ࡣ㸪ᤄධࡋ࡞ࡗࡓ∵ẚ᭱㐩 ࡋࡓࡁࡢᖹᆒ┤ᚄࡀᑠࡉ࠸ࡇࢆሗ࿌ࡋ࡚࠸ࡿ㸦5㸧ࠋࡇࡢࡇࡣ㸪ᖍ༸⬊Ⓨ⫱ᮇ㛫
୰ࡢ⾑୰P4⃰ᗘࡼࡾᖍ༸⬊ࡢⓎ⫱ࡀไᚚࡉࢀࡿࡇࢆពࡋ࡚࠸ࡿࠋࡋࡋ࡞ࡀࡽ㸪
ୖグࡢሗ࿌ࡣ㸪⭐ෆ␃⨨ᆺP4〇ࢆᤄධࡋࡓ࢘ࢩࢆ⏝࠸ࡓヨ㦂࡛࠶ࡾ㸪W1DFࡢⓎ⫱ᮇ 㛫୰ࢆ㏻ࡋ࡚ᖖ⾑୰P4⃰ᗘࡣ㧗್࡛࠶ࡿࡇࡽ㸪➨2❶࠾ࡅࡿW2DFࡢ㧗࠸⾑୰
P4⃰ᗘ᮲௳ୗ࡛ࡢⓎ⫱⎔ቃ㢮ఝࡋࡓࡶࡢ࡛࠶ࡿ⪃࠼ࡽࢀࡿࠋࡑࡢࡓࡵ㸪⮬↛Ⓨ⫱᮲
௳ୗ࡛ࡢDay 6࠾ࡅࡿ⾑୰P4⃰ᗘࡣ㸪W1DFࡁ࡞ᙳ㡪ࢆ࠼࡞࠸᥎ ࡉࢀࡓࠋ
Gintherࡽ㸦42㸧ࡣᮍ⤒⏘∵ࢆ⏝࠸ࡓヨ㦂࠾࠸࡚㸪㯤యྠ୍༸ᕢෆ࡛ඹᏑࡍࡿW1DF
ࡣᑐഃࡢ༸ᕢᏑᅾࡍࡿW1DFẚ㍑ࡋ࡚ᖹᆒ┤ᚄࡀᑠࡉ࠸ࡇࢆሗ࿌ࡋ࡚࠸ࡿࠋ⤒
⏘㠀Ἢங∵ࢆ⏝࠸ࡓᮏヨ㦂࠾࠸࡚ࡶ㸪ྠᵝࡢ⤖ᯝࡀᚓࡽࢀࡓࠋ࣮࢝ࣛࢻࣉࣛࢆ⏝࠸ࡓ
65
◊✲࡛㸪㯤యW1DFࡀྠ୍༸ᕢෆ࡛Ⓨ⫱ࡋࡓሙྜ㸪W1DFࡀ㯤యᑐഃࡢ༸ᕢ࡛Ⓨ
⫱ࡋࡓሙྜẚ㸪༸ᕢෆࡢ⾑⟶ᢠ್ࡀపୗࡋ࡚࠾ࡾ㸪W1DFࡢ༸⬊ቨ⾑ὶࡀ㧗࠸ࡇ
ࡀ♧ࡉࢀ࡚࠸ࡿ㸦42㸧ࠋᮏヨ㦂࠾࠸࡚ࡶྠᵝࡢ⌧㇟ࡀ⏕ࡌ࡚࠸ࡓ᥎ ࡉࢀࡿࠋ㐣ཤ ࡢሗ࿌࠾࠸࡚㸪༸⬊ቨ⾑ὶࡣ㸪༸⬊ࡢᶵ⬟ࢆホ౯ࡍࡿࡢ᭷⏝࡛࠶ࡿࡉࢀ࡚࠸ࡿࡓ
ࡵ㸦2㸪42㸪84㸪86㸧㸪ඹᏑ⩌ࡢW1DFࡼࡾከࡃ⾑ᾮࡀ౪⤥ࡉࢀࡿࡇࡣ㸪㓟⣲㸪ᰤ㣴
ࡉࡽࡣLH࡞ࡢᛶ࣍ࣝࣔࣥࡢ౪⤥㔞㸦109㸧ࢆቑࡸࡋ㸪ࡑࡢ⤖ᯝ㸪༸⬊ෆࡢ⣽⬊ࡢቑ Ṫࡸ࣍ࣝࣔࣥ⏘⏕ࡀቑຍࡋ࡚㸪ᖍ༸⬊ࡢⓎ⫱ࢆಁ㐍ࡋࡓ⪃࠼ࡽࢀࡿࠋ୍᪉࡛㸪ᮏヨ
㦂࡛ࡣ㸪Day 6࠾ࡅࡿ⾑୰P4⃰ᗘࢆඹᏑ⩌㠀ඹᏑ⩌࡛ẚ㍑ࡋࡓࡇࢁ㸪㠀ඹᏑ⩌࡛
᭷ព㧗࠸ࡇࡀ♧ࡉࢀࡓࠋࡇࡢ⤖ᯝࢆࡶࡓࡽࡋࡓཎᅉࡣ࡛᫂࠶ࡾ㸪ᮏヨ㦂࡛ࡣ㯤య ࡢᖹᆒ┤ᚄࡢࢹ࣮ࢱࢆ♧ࡋ࡚࠸࡞࠸ࡓࡵ㸪㯤యࡢⓎ⫱ᕪ␗ࡀ⏕ࡌࡓࡇࡼࡿ⤖ᯝ࡛
࠶ࡿࡢ㸪W1DFࡀ༸ᕢෆᏑᅾࡍࡿࡇ࡛㯤యᶵ⬟㈇ࡢᙳ㡪ࢆ࠼ࡓ⤖ᯝ࡞ࡢ㸪
᫂ࡽ࡛ࡁ࡞ࡗࡓࠋ
ࡑࡇ࡛㸪ヨ㦂2࡛ࡣ㸪ඹᏑ⩌㠀ඹᏑ⩌࡛ࡢW1DFࡢᛶ㉁ࢆヲ⣽᳨ウࡍࡿࡓࡵ㸪⤒
⏘Ἢங∵ࢆ⏝࠸࡚㸪ඹᏑ⩌㠀ඹᏑ⩌ࡢW1DF㯤యࡢⓎ⫱ືែ㸪⾑୰P4⃰ᗘ࠾ࡼࡧ༸
⬊ᾮࢫࢸࣟࢻ࣍ࣝࣔࣥ⃰ᗘࢆẚ㍑ࡋࡓࠋヨ㦂2࡛ࡣ㸪Day 0ࡽ4ࡲ࡛ࡢ㯤యࡢⓎ⫱
ືែ࠾ࡼࡧ⾑୰P4⃰ᗘ᥎⛣ࡣඹᏑ⩌㠀ඹᏑ⩌㛫࡛ᕪࡣ࡞ࡃ㸪⾑୰P4⃰ᗘ㛵ࡋ࡚ࡣ㸪 ヨ㦂1ྠᵝࡢ⤖ᯝࡣᚓࡽࢀ࡞ࡗࡓࠋࡲࡓ㸪W1DFࡢᖹᆒ┤ᚄ᥎⛣࠾࠸࡚ࡶඹᏑ⩌
࡛㧗ࡵࡢ᥎⛣ࢆ♧ࡋ࡚࠸ࡓࡀ㸪᭷ព࡞ᕪࡣࡳࡽࢀ࡞ࡗࡓࠋࡇࡢཎᅉࡋ࡚㸪ᮏヨ㦂࡛
ࡣ༸⬊ἼⓎ⌧ᚋ5᪥┠ࡲ࡛ࡋືែࢆ㏣㊧ࡋ࡚࠾ࡽࡎ㸪ヨ㦂1࡛ࡣ7᪥┠↔Ⅼࢆᙜ࡚
࡚࠸ࡓࡓࡵ㸪ྠᵝࡢ⤖ᯝࡀᚓࡽࢀ࡞ࡗࡓ⪃࠼ࡽࢀࡿࠋDay 4࡛ࡢW1DFࡢ༸⬊ᾮ୰
ࢫࢸࣟࢻ࣍ࣝࣔࣥࢆ ᐃࡋࡓࡇࢁ㸪ඹᏑ⩌࡛P4⃰ᗘࡀ᭷ព㧗್ࢆ♧ࡋࡓࠋࡋࡋ
࡞ࡀࡽ㸪༸⬊ᾮE2⃰ᗘࡸ A4⃰ᗘ᭷ព࡞ᕪࡣࡳࡽࢀ࡞ࡗࡓࠋ༸⬊ෆ࡛ࢫࢸࣟࢻ࣍
ࣝࣔࣥࡀྜᡂࡉࢀࡿ㐣⛬ࡣ㸪༸⬊ቨࡢෆ༸⬊⭷⣽⬊࠾࠸࡚㸪ࢫࢸࣟࢻ࣍ࣝࣔࣥࡢᇶ
㉁࡞ࡿࢥࣞࢫࢸ࣮ࣟࣝࡀ⣽⬊ෆྲྀࡾ㎸ࡲࢀࡿࡇࡽጞࡲࡾ㸪ࡇࡢࢥࣞࢫࢸ࣮ࣟࣝ
66
ࡣࣉࣞࢢࢿࣀࣟࣥኚࡉࢀ㸪ࡑࡢᚋࣉࣞࢢࢿࣀࣟࣥࡽ P4ኚࡉࢀࡿ㸦22㸧ࠋࡑ ࡢᚋ㸪༸⬊⭷⣽⬊ෆ࡛P4ࡣA4ኚࡉࢀࡿ㸦31㸪59㸧ࠋࡉࡽA4ࡣ༸⬊⭷⣽⬊ࡽ㢛
⢏ᒙ⣽⬊⛣⾜ࡋࡑࡇ࡛E2ኚࡉࢀࡿ㸦12㸧ࡇ࡛༸⬊ෆ࡛ࢫࢸࣟࢻ࣍ࣝࣔࣥࡀ⏘
⏕ࡉࢀ࡚࠸ࡿࠋᅇࡢ⤖ᯝ࡛ࡣ㸪A4࠾ࡼࡧE2⃰ᗘᕪࡣࡳࡽࢀ࡞ࡗࡓࡇࡽ㸪ඹᏑ
⩌࠾ࡼࡧ㠀ඹᏑ⩌ࡑࢀࡒࢀࡢᖍ༸⬊ࡢ༸⬊⭷⣽⬊࠾ࡼࡧ㢛⢏ᒙ⣽⬊ࡢࢫࢸࣟࢻ࣍ࣝ
ࣔࣥ⏘⏕⬟ᕪࡣ࡞࠸ࡇࡀ᥎ ࡉࢀࡿࠋࡑࡢࡓࡵ㸪༸⬊ᾮP4⃰ᗘࡀඹᏑ⩌࡛㧗࠸⌮⏤
ࡋ࡚㸪༸⬊࡛ࡢP4⏘⏕⬟ࡀ㧗ࡗࡓࡓࡵ᥎ ࡍࡿࡇࡣ㞴ࡋ࠸ࠋ㐣ཤࡢሗ࿌࡛㸪༸
ᕢෆ࡛ࡢ୍ࡘࡢື⬦ࡽ㯤యࡑࡢ㏆㞄ࡢ༸⬊ື⬦ᯞࢆఙࡤࡋ࡚࠸ࡿྍ⬟ᛶࡀ㸪ࣄࢺ ࡢ༸ᕢࢆ⏝࠸ࡓ◊✲࡛♧ࡉࢀ࡚࠸ࡿ㸦75㸧ࠋࡇࡢࡇࡣ㸪㯤యࡽࡢ⾑⟶ࡀྠ୍༸ᕢෆ
Ꮡᅾࡍࡿ༸⬊ቨᏑᅾࡍࡿẟ⣽⾑⟶࿀ྜࡍࡿࡇ࡛㸪㯤యࡽᨺฟࡉࢀࡓ㧗⃰ᗘࡢP4
ࡀ༸⬊౪⤥ࡉࢀ㸪༸⬊ᾮෆᾐ㏱ࡋ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋᮏヨ㦂࡛ࡣ㸪ࡑࡢ௬ ㄝࢆド᫂ࡍࡿࢹ࣮ࢱࢆ♧ࡋ࡚࠸࡞࠸ࡀ㸪ᮏヨ㦂࡛ᚓࡽࢀࡓ⤖ᯝࡣ㸪ࡇࡢ௬ㄝࡢྍ⬟ᛶࢆ
♧၀ࡍࡿࡶࡢ⪃࠼ࡽࢀࡿࠋࡲࡓ㸪⾑୰ E2⃰ᗘࡣඹᏑ⩌࡛㧗࠸ഴྥࢆ♧ࡋࡓࠋࡇࢀࡣ㸪
Ginther ࡽ㸦42㸧ࡀᮍ⤒⏘∵ࢆ⏝࠸࡚⾜ࡗࡓ◊✲࡛ሗ࿌ࡋ࡚࠸ࡿࡼ࠺㸪㯤య W1DF
ࡀྠ୍༸ᕢෆ࡛ඹᏑࡍࡿሙྜ㸪W1DFࡢ༸⬊ቨ⾑ὶࡀ㠀ඹᏑࡢሙྜẚ࡚ࡁ࠸ࡇ
ࡽ㸪ᮏヨ㦂࠾࠸࡚ࡶ㸪ඹᏑ⩌࡛ࡢW1DFࡢ⾑ᾮ㑏ὶࡀࡼࡾࡁࡃ㸪ᖍ༸⬊ෆ࡛
⏘⏕ࡉࢀࡓE2ࡢᨺฟࡀஹ㐍ࡋࡓࡇࡀཎᅉ⪃࠼ࡽࢀࡿࠋࡋࡋ࡞ࡀࡽ㸪ᮏヨ㦂࡛ࡣ༸
⬊ቨ⾑ὶࡢホ౯ࡣ⾜ࡗ࡚࠾ࡽࡎ㸪༑ศ᳨ド࡛ࡁࡿࢹ࣮ࢱࡣ࡞࠸ࠋ㠀Ἢங⤒⏘∵ࢆ⏝࠸
࡚ࡢ༸⬊ቨ⾑ὶホ౯ࢆ⾜࠸㸪ࡇࡢཎᅉࢆ᫂ࡽࡍࡿ◊✲ࢆ⾜ࡗ࡚࠸ࡃᚲせࡀ࠶ࡿ⪃
࠼ࡿࠋ
3㸫6㸬ᑠᣓ
ᮏᐇ㦂࡛ࡣ㸪㠀Ἢங⤒⏘∵ࢆ⏝࠸࡚W1DFࡢⓎ⫱ࡸᛶ㉁ࢆไᚚࡍࡿせᅉ㸪ࡲࡓඹᏑ⩌
㠀ඹᏑ⩌࡛ࡢW1DFࡢᛶ㉁ࡘ࠸࡚ㄪࡓࠋࡑࡢ⤖ᯝ㸪ヨ㦂1࠾࠸࡚༸☜ㄆ᪥
67
ࡽ7᪥┠ࡢW1DFࡢᖹᆒ┤ᚄ⾑୰P4⃰ᗘࡢ㛫┦㛵㛵ಀࡣ࡞࠸ࡇࡀ♧ࡉࢀࡓࡀ㸪 W1DFࡀ㯤యྠ୍༸ᕢෆ࡛ඹᏑࡍࡿ㸪ඹᏑࡋ࡞࠸W1DFẚ࡚༸☜ㄆ᪥ࡽ㸵
᪥┠ࡢᖹᆒ┤ᚄࡀࡁࡃ࡞ࡾ㸪⾑୰P4⃰ᗘࡶ㧗್ࢆ♧ࡍࡇࡀ♧ࡉࢀࡓࠋࡇࢀࡽࡢࡇ
ࡽ㸪W1DFࡢᙧែࡣ⾑୰P4⃰ᗘ࡛ࡣ࡞ࡃ㸪༸ᕢෆ࡛ࡢ㯤యࡢ⨨㛵ಀࡀࡁࡃ㛵
ࡍࡿࡇࡀ♧၀ࡉࢀࡓࠋヨ㦂2࠾࠸࡚㸪༸☜ㄆ᪥ࡽ5᪥┠ࡲ࡛ࡢᖍ༸⬊ࡢᖹ ᆒ┤ᚄ࠾ࡼࡧ⾑୰P4⃰ᗘඹᏑ⩌㠀ඹᏑ⩌ࡢ㛫࡛ᕪࡣࡳࡽࢀ࡞ࡗࡓࡀ㸪༸⬊ᾮ୰
ࡢP4⃰ᗘࡀඹᏑ⩌࡛㧗࠸࠸࠺⤖ᯝࡀᚓࡽࢀࡓࠋࡇࡢ⌧㇟ࡀ⏕ࡌࡓཎᅉࡋ࡚㸪༸ᕢෆ
࡛ࡢ㏆㞄ࡢ㯤యࡽ⏘⏕ࡉࢀࡓ P4ࡀ⾑⟶ࢆ㏻ࡌ࡚ᖍ༸⬊ࡢ༸⬊ቨẟ⣽⾑⟶ධࡋ㸪 P4ࡀ༸⬊ᾮෆᾐ㏱ࡋࡓ࠸࠺ྍ⬟ᛶࡶ⪃࠼ࡽࢀࡿࡀ㸪༸ᕢෆࡢ⾑⟶㉮⾜ࡸᙧᡂࡢ≧ἣ ࡢゎ᫂ࡶྵࡵ࡚᭦࡞ࡿ◊✲ࢆ⾜ࡗ࡚࠸ࡃᚲせࡀ࠶ࡿ⪃࠼ࡽࢀࡿࠋ
Table 3.1. Plasma P
4concentration on Day 6.
IG CG P-value
P
4(ng/ml) 2.7 㼼 0.3 3.5 㼼 0.3 P < 0.05
68
Values are mean 㼼 SEM.
Day0 = The day of the first follicular wave emergence.
IG; Ipsilateral group: Dominant follicle (DF) ipsilateral to the corpus luteum (CL).
CG; Contralateral group: DF contralateral to the CL.
Fig. 3.1.
The linear relationship between plasma P4 concentration and diameter of the first wave dominant follicle on Day 6. Day 0 = The day of the first follicular wave emergence.
R=0.23 P:NS
1 .0 2 .0 3 .0 4 .0 5 .0 6 .0 7 .0
13 14 15 16 17 18
Plasma P4 concentration (ng/ml)
Diameter of the first wave dominant follicle (mm)
69
Fig. 3.2.
The linear relationship between plasma P4 concentration and diameter of the first wave dominant follicle (DF) on Day6 in IG and CG. Day0 = The day of the first follicular wave emergence. IG;
Ipsilateral group: DF ipsilateral to the corpus luteum (CL). CG;
Contralateral group: DF contralateral to the CL.
R=0.36 P:NS R=0.12
P:NS
1 .0 2 .0 3 .0 4 .0 5 .0 6 .0 7 .0
13 14 15 16 17 18
IG C G
Plasma P4 concentration (ng/ml)
Diameter of the first wave dominant follicle (mm)
70
Table 3.2. Diameter of the first follicular wave dominant follicle on Day6.
IG CG P-value
Diameter (mm) 15.5 㼼 0.2 14.7 㼼 0.2 P < 0.01
71
Values are mean 㼼 SEM.
Day0 = The day of the first follicular wave emergence.
IG; Ipsilateral group: Dominant follicle (DF) ipsilateral to the corpus luteum (CL).
CG; Contralateral group: DF contralateral to the CL.
Fig. 3.3.
Comparative changes of the first follicular wave dominant follicle (DF) of IG and CG from Day 0 to 4. Day 0 = The day of the first follicular wave emergence. Effect of group (G) (NS), day (D) (P < 0.01) and interaction between group and day (G,D) (NS). IG; Ipsilateral group: DF ipsilateral to the corpus luteum (CL). CG; Contralateral group: DF contralateral to the CL.
Values are mean r SEM of each point.
0 2 4 6 8 10 12 14
Day0 Day1 Day2 Day3 Day4
IG C G
G : NS D : P < 0.001 G,D : NS
Diameter of dominant follicle (mm)
Days from follicular wave emergence
72
0 50 100 150 200 250 300
Day0 Day1 Day2 Day3 Day4
Cross-sectional areaof corpus luteum(mm2)
Days from follicular wave emergence
IG CG
G : NS D : P< 0.001 G,D : NS
Fig. 3.4.
Comparative changes of cross-sectional area of corpus luteum (CL) of IG and CG from Day 0 to 4. Day 0 = The day of the first follicular wave emergence. Effect of group (G) (NS), day (D) (P < 0.001) and interaction between group and day (G,D) (NS). IG; Ipsilateral group: Dominant follicle (DF) ipsilateral to the CL. CG; Contralateral group: DF contralateral to the CL. Values are mean r SEM of each point.
Days from follicular wave emergence
73
Fig. 3.5.
Comparative changes of plasma P4 concentration of IG and CG from Day 0 to 4. Day 0 = The day of the first follicular wave emergence. Effect of group (G) (NS), day (D) (P<0.001) and interaction between group and day (G,D) (NS). IG; Ipsilateral group: Dominant follicle (DF) ipsilateral to the corpus luteum (CL). CG; Contralateral group: DF contralateral to the CL.
Values are mean r SEM of each point.
0 0.5 1 .0 1.5 2.0 2.5 3 .0
Day0 Day1 Day2 Day3 Day4
IG C G
G : NS D : P < 0.001 G,D : NS
Plasma P4 concentration (ng/ml)
Days from follicular wave emergence
74
Table 3.3. Plasma E
2concentration on Day4.
IG CG P-value
E
2(pg/ml) 1.69 㼼 0.12 1.51 㼼 0.15 P < 0.1
75
Values are mean 㼼 SEM.
Day0 = The day of the first follicular wave emergence.
IG; Ipsilateral group: Dominant follicle (DF) ipsilateral to the corpus luteum (CL).
CG; Contralateral group: DF contralateral to the CL.
Table 3.4. Sex steroids concentration in follicular fluid on Day4.
IG CG P-value
P
4(ng/ml) E
2(ng/ml) A
4(ng/ml)
48.8 㼼 12.7 16.2 㼼 3.2 419.2 㼼 33.2 339.4 㼼 53.5
84.6 㼼 23.1 102.7 㼼 40.2
P < 0.05 NS NS
Values are mean 㼼 SEM.
Day0 = The day of the first follicular wave emergence.
IG; Ipsilateral group: Dominant follicle (DF) ipsilateral to the corpus luteum (CL).
76
CG; Contralateral group: DF contralateral to the CL.
77