Ꮫ㝔༤ኈ2ᖺ㸸ᮌ㈗༤
Ꮫ㝔༤ኈ2ᖺ㸸Khoirun Nisa㸦10᭶ධᏛ㸧
Ꮫ㝔༤ኈ2ᖺ㸸᪂⨾
Ꮫ㝔༤ኈ3ᖺ㸸ᮤ㞷ᯘ
◊ ✲ ဨ㸸Subehan Ambo Lallo 㸦4᭶ࠥ6᭶㸧
◊ ✲ ဨ㸸Abdul Rahim㸦4᭶ࠥ10᭶㸧
◊ ✲ ဨ㸸ඣ⋢⊛
◊ ✲ ဨ㸸Nwet Nwet Win㸦5᭶ࠥ㸧
◊ ✲ ဨ㸸Hoai Thi Nguyen㸦11᭶ࠥ㸧
◊ ✲ ဨ㸸࿘ᬡᕼ㸦9᭶ࠥ3᭶㸧 ۍ
ۍᏛᏛ㸦㸦ಟಟኈ㸪㸪༤༤ኈ㸧㸧ྲྀྲྀᚓ⪅㻌 ༤ኈㄽᩥ㸸
Dibwe Dya Fita Eddy㸸Constituents of Congolese Medicinal Plants,Garcinia huillensis,Securidaca longepedunculata, and Aframomum melegueta and Their Preferential Cytotoxic Activity against Human Pancreatic Cancer Cell Lines
㻌
」
」ྜ⸆≀⸆⌮Ꮫศ㔝 Division of Medicinal Pharmacology
ᩍ ᤵ
ᯇᮏḠ୕
Professor Kinzo Matsumoto (Ph.D.)ᩍᤵ
ᮾ⏣㐨ஂ
Associate Professor Michihisa Tohda (Ph.D.)ຓ ᩍ
⸨ཎ༤
Assistant Professor Hironori Fujiwara (Ph.D.)㻌 ۍ
ۍ◊◊✲┠ⓗ㻌
㻌 ୰ᯡ⚄⤒⣔ᝈࡢែⓎᶵᵓ㛵ࡍࡿ⸆⌮Ꮫⓗ◊✲ࢆ⾜࠺ࡶ㸪₎⸆ࢆࡣࡌࡵ㸪
」ྜᡂศࡽ࡞ࡿ⸆≀ࡢ⸆ຠ㛵ࡍࡿィ㔞⸆⌮Ꮫⓗホ౯㸪స⏝ᮏయࡢ㏣ồ࠾ࡼࡧศᏊ࡛ࣞ࣋ࣝ
ࡢస⏝ᶵᗎࡢゎ᫂ࢆ┠ⓗࡋࡓ◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ
㻌
ۍ
ۍ◊◊✲ᴫせ㻌 Ϩ
Ϩ㻕㻕㻌㻌 ୰୰ᯡ⚄⤒⣔ᝈࡢែⓎᶵᵓ㛵ࡍࡿᇶ♏◊✲㻌㻌
㻌 1)ᚰ⌮ⓗࢫࢺࣞࢫ࡛㉳ࡇࡿ␗ᖖ⾜ື࠾ࡼࡧ⸆≀ᛂ⟅ᛶኚࡢ⚄⤒ᶵᵓ㸪⚄⤒ᶵ⬟ಟ㣭ᅉᏊࡢᙺ
㛵ࡍࡿ◊✲
2)ែࣔࢹࣝ࠾ࡅࡿ⚄⤒ఏ㐩≀㉁➼ࡢෆᅾᛶᅉᏊࡸኳ↛⸆≀ᡂศࡢ⬻ෆືែ㛵ࡍࡿ◊✲㻌 ϩ
ϩ㻕㻕㻌㻌 」」ྜ⸆≀࠾࠾ࡼࡧࡑࡑࡢᡂศࡢ୰ᯡస⏝㛵ࡍࡿ⚄⤒⸆⌮Ꮫⓗ◊✲㻌㻌
㻌 1) ㄆ▱ែࡢin vivo࠾ࡼࡧin vitroࣔࢹࣝ⣔࠾ࡅࡿ₎⸆࠾ࡼࡧ₎⸆ᡂศࡢᢠㄆ▱స
⏝⚄⤒ಖㆤస⏝ࡢホ౯࡞ࡽࡧస⏝ศᏊᶵᵓࡢゎ᫂
2) ㄆ▱㐍⾜ࢆᢚไࡍࡿ⚄⤒⣽⬊ಖㆤ⸆࠾ࡼࡧࢱ࢘⺮ⓑ㐣ࣜࣥ㓟ᢚไ⸆ࡢ㛤Ⓨࢆᚿྥࡋ ࡓఏ⤫⸆≀࣭Ẹ᪘⸆ࡢ⸆⌮స⏝ࡢ᥈⣴స⏝ᶵᗎࡢゎᯒ
3)⚄⤒ఏ㐩ཷᐜయࡢᶵ⬟ゎᯒ࠾ࡼࡧཷᐜయస⏝⸆ࡢศᏊᶵᵓ㛵ࡍࡿ㟁Ẽ⏕⌮Ꮫⓗ࣭⏕Ꮫⓗ
◊✲㻌 Ϫ
Ϫ㻕㻕㻌㻌 ₎⸆⌮ㄽᑐࡍࡿ࢚ࣅࢹࣥࢫࡢࡑࡢ⌮ㄽࢆ⏝ࡋࡓែ㛵㐃ᅉᏊࡢ༢㞳㸪ᶵ⬟
ゎ
ゎᯒ㸪₎⸆స⏝㛵ࡍࡿ◊✲㻌㻌
㻌 1) ศᏊⓗどⅬᇶ࡙ࡃศᯒⓗゎᯒἲ㌟ⓗどⅬᇶ࡙ࡃ⤫ྜ⸆⌮Ꮫⓗᡭἲࡢ୧㠃ࡽࡢ
₎⸆⌮ㄽ㸦⾜ㄽ㸪ᑐ⸆➼㸧ࡢ࢚ࣅࢹࣥࢫࡢ
2) 㑇ఏᏊᑟධ⣽⬊ࢆ⏝࠸ࡓ⚄⤒ఏ㐩ᶵ⬟ཬࡰࡍ₎⸆స⏝࠾ࡼࡧࡑࡢศᏊⓗᶵᗎ㛵ࡍࡿ
ࣜࣝࢱ࣒ゎᯒ
3) ₎⸆⌮ㄽࢆᇶ┙ࡋࡓ࠺ࡘែ㛵㐃ᅉᏊࡢྠᐃ༢㞳㸪ࡑࡢⓎ⌧ไᚚࡼࡿືⓗᶵ⬟ゎ ᯒ㸪࡞ࡽࡧ」ྜ⸆≀⸆⌮ᏛⓗどⅬ❧⬮ࡋࡓ₎⸆స⏝ࡢゎᯒ
㻌 㻌
ۍ
ۍཎཎⴭㄽᩥ㻌
1) Mizuki D., Qi Z., Tanaka K., Fujiwara H., Ishikawa T., Higuchi Y., Matsumoto K.: Butea superba-induced amelioration of cognitive and emotional deficits in olfactory bulbectomized mice and putative mechanisms underlying its actions. J Pharmacol Sci., 124:457-467, 2014.
2) Thiratmatrakul S., Yenjai C., Waiwut P., Vajragupta O., Reubroycharoen P., Tohda M., Boonyarat C.: Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease. Eur J Med Chem., 75:21-30, 2014.
3) Okada R., Matsumoto K., Tsushima R., Fujiwara H., Tsuneyama K.: Social isolation
ែ
ែ ไ ไ ᚚ ᚚ 㒊 㒊 㛛 㛛
病態制御部門
stress-induced fear memory deficit is mediated by down-regulated neuro-signaling system and Egr-1 expression in the brain. Neurochem Res., 39:875-882, 2014.
4) Fujiwara H., Kimura J., Sakamoto M., Yokosuka A., Mimaki Y., Murata K., Yamaguchi K., Ohizumi Y.: Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells. Can J Physiol Pharmacol., 92:351-355, 2014.
5) Inada C., Niu Y., Matsumoto K., Le X. T., Fujiwara H.: Possible involvement of VEGF signaling system in rescuing effect of endogenous acetylcholine on NMDA-induced long-lasting hippocampal cell damage in organotypic hippocampal slice cultures. Neurochem Int., 75:39-47, 2014.
6) Monthakantirat O., Sukano W., Umehara K., Noguchi H., Chulikhit Y., Matsumoto K.: Effect of miroestrol on ovariectomy-induced cognitive impairment and lipid peroxidation in mouse brain.
Phytomedicine., 21:1249-1255, 2014.
7) Mizuki D., Matsumoto K., Tanaka K., Le X. T., Fujiwara H., Ishikawa T., Higuchi Y.:
Antidepressant-like effect of Butea superbain mice exposed to chronic mild stress and its possible mechanism of action. J Ethnopharmacol., 156:16-25, 2014.
8) Tohda M.: Changes in the expression of BNIP-3 and other neuronal factors during the cultivation period of primary cultured rat cerebral cortical neurons and an assessment of each factor’s functions. Cell Signalling and Trafficking, DOI: 10.7243/2054-1481-2-1, 2014.
ۍ ۍ⥲⥲ㄝ㻌
1) Tohda M.: Serotonin 2C Receptor as a Superhero: Diversities and Talents in the RNA Universe for Editing, Variant, Small RNA and Other Expected Functional RNAs. J Pharmacol Sci., 126:321-328, 2014.
ۍ
ۍᏛᏛሗ࿌㻌㻌㻌㸦㸦㻖㻖㻦㻌≉≉ูㅮ₇㸪㸪ࢩࢩ࣏ࣥࢪ࣒࢘㸪㸪࣮࣡࣡ࢡࢩࣙࢵࣉ➼㸧㻌㻌
1) Xoan Thi Le, Hang Thi Nguyet Pham, Tai Van Nguyen, Phuong Thi Nguyen, Ken Tanaka, Kinzo Matsumoto㸸Neuroprotective effects of Bacosides on ischemia-induced neuronal cell damage in organotypic hippocampal slice culture㸦ఏ⤫⸆≀Bacopa monnieriࡢ⾑ᛶᾏ㤿⚄⤒㞀ᐖᑐ ࡍࡿಖㆤస⏝ࡑࡢᶵᵓ㸸ᾏ㤿ᇵ㣴⤌⧊⣔ࢆ⏝࠸ࡓ᳨ウ㸧㸬➨ 87ᅇ᪥ᮏ⸆⌮Ꮫᖺ㸪 2014, 3, 19-21㸪ྎ㸬
2) ᒸ⏣ு㸪ᯇᮏḠ୕㸪Ỉᮌኴ⬶㸪⸨ཎ༤㸸Social isolation impairs sociability and conditional fear memory via central dopaminergic and cholinergic systems, respectively, in mice㸦㝸㞳㣫⫱
ࢫࢺࣞࢫࡼࡿ♫ᛶపୗ࠾ࡼࡧᜍᛧグ᠈㞀ᐖࡑࡢⓎᶵᗎ㸧㸬➨ 87ᅇ᪥ᮏ⸆⌮Ꮫ
ᖺ㸪2014, 3, 19-21㸪ྎ㸬
3) Ỉᮌኴ⬶㸪ᯇᮏḠ୕㸪⏣୰ㅬ㸪⸨ཎ༤㸪Le Thi Xoan㸪ᵽཱྀ ⩏ὒ㸪▼ᕝຮ㸸Antidepressant-like effects of Butea superba in mice exposed to chronic mild stress and its possible mechanism of
action㸦៏ᛶࢫࢺࣞࢫࣔࢹ࣐ࣝ࢘ࢫᑐࡍࡿࢱẸ᪘⸆ Butea superbaࡢᨵၿస⏝ࡑࡢ
ᶵᗎ㸧㸬➨87ᅇ᪥ᮏ⸆⌮Ꮫᖺ㸪2014, 3, 19-21㸪ྎ㸬
* 4) Kinzo Matsumoto, Yimin Niu, Qi Zhao, Hironori Fujiwara, Sachie Hamada, Jun-Ichiro Oka㸸 Chotosan and cognitive deficits attributable to aging and diabetes.➨87ᅇ᪥ᮏ⸆⌮Ꮫᖺ㸪 2014, 3, 19-21㸪ྎ㸬
* 5) ᯇᮏḠ୕㸸ㄆ▱ࡢ₎᪉⸆⒪㸸ࡑࡢ⮫ᗋ࣭๓⮫ᗋ࢚ࣅࢹࣥࢫ㸬➨13ᅇᒸᒣㄆ▱◊✲
㸪2014, 4, 18㸪ᒸᒣ㸦≉ูㅮ₇㸪ᣍᚅ㸧㸬
* 6) Kinzo Matsumoto: Traditional Chinese and Kampo medicines targeting diabetes- and aging-induced cognitive and emotional deficits: Neuropharmacological evidence from Chotosan (Gouteng-san). IUPHAR Natural Product Session Symposium, The 17th World Congress of Basic and Clinical Pharmacology, 2014, 7, 13-18, Cape Town, South Africa.
7) Yimin Niu, Feng Li, Hironori Fujiwara, Ken Tanaka, Shiro Watanabe, Sachie Sasaki-Hamada, Jun-Ichiro Oka, Kinzo Matsumoto: Chemical profiling of endogenous and exogenous markers of
chitosan in an animal model of diabetes.➨31ᅇ₎་⸆Ꮫ㸪2014, 8, 30-31㸪༓ⴥ㸬 8) Orawan Monthakantirat, Yaowared Chulikhit, Kinzo Matsumoto, Wichitsak Sukano, Kaoru
Umehara, Hiroshi Noguchi: Effects of miroestrol on ovariectomy-induced cognitive deficit and lipid peroxidation in mouse brain.➨31ᅇ₎་⸆Ꮫ㸪2014, 8, 30-31㸪༓ⴥ㸬
9) ᮾ⏣㐨ஂ㸪ᮧୖᏕᑑ㸪ᩘ㤿ᜏᖹ㸸㓟Ჱோࡢຍ⇕ಟࡼࡿᡂศኚ⸆⌮స⏝ࡢ㛵㐃 ᛶ㛵ࡍࡿ᳨ウ㸬➨31ᅇ₎་⸆Ꮫ㸪2014, 8, 30-31㸪༓ⴥ㸬
10) ᒸ⏣ு㸪ὠᓥ㑈ᖹ㸪㡑ᇁ⩚㸪㉿ᇸ㸪⸨ཎ༤㸪ⲨᮌⰋኴ㸪▮㒊Ṋኈ㸪ᯇᮏḠ୕㸸㝸㞳㣫
⫱࣐࢘ࢫ⾜ື㞀ᐖᑐࡍࡿ㓟Ჱோࡢᨵၿຠᯝࡢ᳨ウ㸬➨ 65 ᅇ᪥ᮏ⸆⌮Ꮫ㒊㸪 2014, 9, 26-27㸪⚟ᓥ㸬
11) 㕥ᮌ࠶ࡎࡉ㸪℈⏣ᖾᜨ㸪ᜏᒸᘺ⏕ 㸪ᯇᮏḠ୕㸪ᒸ῟୍㑻㸸ᙉไỈὋヨ㦂ࢆ⏝࠸ࡓ㔮⸨ᩓ ࡢᢠ࠺ࡘᵝస⏝ࡢ᳨ウ㸬➨131ᅇ᪥ᮏ⸆⌮Ꮫ㛵ᮾ㒊㸪2014, 10, 11㸪ᶓ㸬
12) Ỉᮌ ኴ⬶㸪ᯇᮏ Ḡ୕㸸Antidepressant-like effect of Butea superbain mouse models of depression and its possible mechanism of action. ➨2ᅇ⸆㣗ᅜ㝿࢝ࣥࣇࣞࣥࢫ㸪2014, 11, 5-6㸪㟼ᒸ㸬
* 13) ᯇᮏḠ୕㸪∵୍Ẹ㸪✄⏣༓㤶Ꮚ㸪⸨ཎ༤㸪ᮤᓠ㸪⏣୰ㅬ㸪Ώ㎶ᚿᮁ㸪⏣ᖾᜨ㸪ᒸ῟
୍㑻㸸㔮⸨ᩓᢞࡼࡾ⬻ෆฟ⌧ࡍࡿ⏕⸆⏤᮶ศᏊ⏕యෆศᏊ㸸2ᆺ⢾ᒀࣔࢹ࣐ࣝ
࢘ࢫ࡛ࡢex vivoࢣ࣑࢝ࣝࣉࣟࣇࣜࣥࢢゎᯒ㸬➨13ᅇ᪥ᮏ⮫ᗋ୰་⸆ᏛᏛ⾡ࢩ
࣏ࣥࢪ࣒࢘㸪2014, 12, 6㸪㜰㸬
ۍ
ۍࡑࡑࡢ
㻌 1) ᮾ⏣ 㐨ஂ㸸᪂ห⤂㸸ື≀ᐇ㦂௦᭰Ᏻᛶヨ㦂ࣉࣟࢺࢥࣝ㞟㸸ࣇ࣐ࣝࢩ50 (1) 33 㻌 2) ᮾ⏣ 㐨ஂ㸸᪂ห⤂㸸ࡃࡍࡾᗣ ኟ⛅㸸ࣇ࣐ࣝࢩ50 (4) 304
㻌 3) ᮾ⏣ 㐨ஂ㸸᪂ห⤂㸸ࡺࡽࡂ࣭ࢲࢼ࣑ࢡࢫ⏕యᶵ⬟㸸ࣇ࣐ࣝࢩ50 (4) 324 㻌 4) ᮾ⏣ 㐨ஂ㸸᪂ห⤂㸸⮫ᗋ་ࡢࡓࡵࡢ₎᪉⸆ᴫㄽ㸸ࣇ࣐ࣝࢩ50 (6) 567
5) ᮾ⏣ 㐨ஂ㸸᪂ห⤂㸸⁒ࢀࡿ⬻ ேࡣ࡞ࡐ౫Ꮡ࡞ࡿࡢ㸸ࣇ࣐ࣝࢩ50 (10) 1017 6) ᮾ⏣ 㐨ஂ㸸᪂ห⤂㸸⸆᳨ᰝ2014㸸ࣇ࣐ࣝࢩ50 (11) 1140
7) ᮾ⏣ 㐨ஂ㸸ㄯヰᐊ㸸ࢣࣟࣜࣥࡢᱩ㸸ࣇ࣐ࣝࢩ50 (12) 1265
ۍ
ۍඹඹྠ◊✲
◊✲ᡤෆ
㻌 1) Ώ㎶ᚿᮁ ༤ኈ㸸ᰤ㣴௦ㅰᏛศ㔝㸪ࠕ₎᪉⸆ࡢ⸆ຠ࣓ࢹ࢚࣮ࢱ㛵ࡍࡿ◊✲ࠖ࠾ࡼࡧࠕㄆ
▱ࡢண㜵⒪㈨ࡍࡿኳ↛⸆㣗≀ࡢ㛤Ⓨࠖ㸪2013㹼
㻌 2) ᮤᓠ ༤ኈ㸸ᣐⅬᴗ᥎㐍ᐊ㸪ࠕ₎᪉⸆ࡢ⸆ຠ࣓ࢹ࢚࣮ࢱ㛵ࡍࡿ◊✲ࠖ࠾ࡼࡧࠕ₎᪉
⸆ࡢ⸆ຠࢆ⏝ࡋࡓADHDⓎᅉᏊࡢ᥈⣴ྠᐃᶵ⬟ゎᯒࠖ㸪2008㹼 Ꮫෆ
㻌 1) ᖖᒣᖾ୍ ༤ኈ㸸Ꮫ㝔་Ꮫ⸆Ꮫ◊✲㒊㸪ࠕ₎᪉⸆ࡢ⸆ຠ࣓ࢹ࢚࣮ࢱ㛵ࡍࡿ◊✲ࠖ࠾
ࡼࡧࠕ₎᪉⸆ࡢ⸆ຠࢆ⏝ࡋࡓADHDⓎᅉᏊࡢ᥈⣴ྠᐃᶵ⬟ゎᯒࠖ㸪2008㹼
㻌 2) ᏳᮾႹಟ ༤ኈ㸸Ꮫ㝔་Ꮫ⸆Ꮫ◊✲㒊㸪ࠕ₎᪉࣭₎⸆ࡢ⪃࠼᪉ᇶ࡙ࡃ₎᪉་Ꮫ࣭
₎⸆స⏝ࡢ⤫ྜⓗゎᯒࠖ㸪2014㹼
㻌 3) ᏳᮾႹಟ ༤ኈ㸸Ꮫ㝔་Ꮫ⸆Ꮫ◊✲㒊㸪す᮲ ᑑኵ ༤ኈ㸸Ꮫ㝔་Ꮫ⸆Ꮫ◊✲㒊㸪㧗ᶫ ດ ༤ኈ㸸Ꮫ㝔་Ꮫ⸆Ꮫ◊✲㒊㸪ᆤぢ ༤அ ༤ኈ㸸ேᩥᏛ㒊㸪ࠕ₎⸆⏬ീゎᯒࡀࡶࡓࡽ
ࡍࣄࢺ⮫ᗋ▱ぢࣔࢹࣝື≀ᐇ㦂ࡢᇉ᰿ࢆ㉺࠼ࡿ࠺ࡘ⒪ࡢ◊✲ࠖ㸪2014㹼 Ꮫእ
㻌 1) ▼ᕝຮ ༤ኈ㸸༓ⴥᏛ་Ꮫ⸆Ꮫ◊✲㝔㸪ࠕㄆ▱ࡢண㜵⒪㈨ࡍࡿኳ↛⸆㣗≀ࡢ㛤Ⓨࠖ㸪 2012㹼2014
㻌 2) ᒸ῟୍㑻 ༤ኈ㸸ᮾி⌮⛉Ꮫ⸆Ꮫ㒊㸪ࠕ⢾ᒀែ࡛Ⓨࡍࡿㄆ▱㞀ᐖᑐࡍࡿ₎᪉⸆ࡢᐇ㦂
ⓗ⒪ࡢ◊✲ࠖ࠾ࡼࡧࠕ㔮⸨ᩓࡢᢠ࠺ࡘస⏝࠾ࡼࡧᢠㄆ▱స⏝㛵ࡍࡿ◊✲ࠖ㸪2012㹼
㻌 3) ⏣୰ㅬ ༤ኈ㸸❧㤋Ꮫ⸆Ꮫ㒊㸪ࠕ₎᪉⸆ࡢ⸆ຠ࣓ࢹ࢚࣮ࢱ㛵ࡍࡿ◊✲ࠖ࠾ࡼࡧࠕㄆ
▱ࡢண㜵⒪㈨ࡍࡿኳ↛⸆㣗≀ࡢ㛤Ⓨࠖ㸪2008㹼
㻌 4) ▮㒊Ṋኈ ༤ኈ㸸ᦤ༡Ꮫ⸆Ꮫ㒊㸪ࠕ㝸㞳㣫⫱ື≀ࣔࢹࣝ࠾ࡅࡿ࢚ࣆࢪ࢙ࢿࢸࢵࢡ࡞⢭
⚄⚄⤒ᛶ㞀ᐖࡢⓎᶵᵓゎ᫂⸆≀㸦₎⸆㸧ไᚚࠖ㸪2014㹼
㻌 5) 㔝ཱྀ༤ྖ ༤ኈ㸪ᱵཎ ⸅ ༤ኈ㸸㟼ᒸ┴❧Ꮫ⸆Ꮫ㒊㸪ࠕPhytoestrogen miroestrolࡢᢠㄆ▱
࠾ࡼࡧᢠࢫࢺࣞࢫస⏝㛵ࡍࡿ◊✲ࠖ㸪2013㹼
㻌 6) 㟷ᮌఀ▱⏨ ༤ኈ㸸ᨺᑕᛶ་Ꮫ◊✲ᡤ㸪ࠕ₎⸆ࡢ⬻ෆస⏝ᶵᵓ㛵ࡍࡿศᏊ࣓࣮ࢪࣥ
ࢢἲࡼࡿゎᯒࠖ㸪2014㹼 ᾏእ
㻌 1) Yaowared Chulikhit ༤ኈ㸸ࢱ࣭ࢥࣥࢣࣥᏛ⸆Ꮫ㒊㸪ࠕㄆ▱࠾ࡼࡧ࠺ࡘࡢண㜵⒪
㈨ࡍࡿኳ↛⸆≀ࡢ㛤Ⓨࠖ㸪2010㹼
㻌 2) Pham Nguiet Thi Hang༤ኈ㸸࣋ࢺࢼ࣒࣭ᅜ❧ኳ↛⸆≀◊✲ᡤ㸪ࠕㄆ▱ࡢண㜵⒪㈨ࡍ
ࡿኳ↛⸆㣗≀ࡢ㛤Ⓨࠖ㸪2010㹼
㻌 3) Nguyen Minh Khoi༤ኈ㸸࣋ࢺࢼ࣒࣭National Institute of Medicinal Materials㸪ࠕ࣋ࢺࢼ࣒⏕
⸆Acanthopanax gracilistylus W. W. Smithࡢᢠㄆ▱ຠᯝࡑࡢస⏝ศᏊᶵᵓ㛵ࡍࡿᐇ㦂
⸆⌮Ꮫⓗ◊✲ࠖ㸪2014㹼 㻌
ۍ
ۍ◊◊✲㈝ྲྀᚓ≧ἣ
1) ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝㸪ᣮᡓⓗⴌⱆ◊✲㸦௦⾲㸸ᯇᮏḠ୕㸧ࠕ₎᪉⸆ࡢ⸆ຠࢆ⏝ࡋࡓ ADHDⓎᅉᏊࡢ᥈⣴ྠᐃᶵ⬟ゎᯒࠖ┤᥋⤒㈝70㸦3/3ᖺ┠㸧
2) ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝㸪ⱝᡭ◊✲B㸦௦⾲㸸⸨ཎ༤㸧ࠕࢱ࢘⺮ⓑࢆᶆⓗࡋࡓ᪂ࡓ࡞₎
᪉⏤᮶ࣝࢶࣁ࣐࣮⒪⸆ࡢ᥈⣴࠾ࡼࡧస⏝ᶵᗎゎ᫂ࠖ┤᥋⤒㈝100㸦2/4ᖺ┠㸧 3) ᖹᡂ26ᖺᗘᏛ㛗㔞⤒㈝㸪ᡓ␎ⓗ⤒㈝㸦௦⾲㸸ᯇᮏḠ୕㸹ศᢸ㸸⸨ཎ ༤㸧ࠕADHDࡢ
࢚ࣆࢪ࢙ࢿࢸࢵࢡࣔࢹࣝ㸸ࡑࡢែゎ᫂㸪ண㜵⒪⸆㛤Ⓨ㸪₎⸆ᛂ⏝ྥࡅࡓᇶ┙
ᵓ⠏ࠖ200
4) ᖹᡂ26ᖺᗘᏛ㛗㔞⤒㈝㸪ᩍ⫱◊✲άᛶ⤒㈝㸦௦⾲㸸ᯇᮏḠ୕㸧ࠕㄆ▱Ⓨ㐜ᘏ
᭷ຠ࡞ኳ↛⸆≀࣭⸆⏝㣗≀ࡢ㛤Ⓨ㛵ࡍࡿ᪥㉺ඹྠ◊✲ࡢࢫࢱ࣮ࢺࢵࣉࠖ30 5) ᖹᡂ26ᖺᗘᏛ㛗㔞⤒㈝㸪㔜Ⅼ◊✲㸦௦⾲㸸ᮾ⏣㐨ஂ㸧ࠕ₎⸆⏬ീゎᯒࡀࡶࡓࡽࡍ
ࣄࢺ⮫ᗋ▱ぢࣔࢹࣝື≀ᐇ㦂ࡢᇉ᰿ࢆ㉺࠼ࡿ࠺ࡘ⒪ࡢ◊✲ࠖ500
6) ᖹᡂ26ᖺᗘ ₎་⸆Ꮫ⥲ྜ◊✲ᡤ ඹྠ⏝࣭ඹྠ◊✲ᣐⅬ㸪≉ᐃ◊✲㸦ᡤෆ௦⾲㸸ᮾ
⏣㐨ஂ㸧ࠕ₎᪉⸆ࡀ᭷ࡍࡿ」㞧⣔ࡢゎᯒࠖࠕ₎᪉࣭₎⸆ࡢ⪃࠼᪉ᇶ࡙ࡃ₎᪉་Ꮫ࣭
₎⸆స⏝ࡢ⤫ྜⓗゎᯒࠖ50
7) ᖹᡂ26ᖺᗘ ₎་⸆Ꮫ⥲ྜ◊✲ᡤ ඹྠ⏝࣭ඹྠ◊✲ᣐⅬ㸪୍⯡◊✲Ϩ㸦ᡤෆ௦⾲㸸 ᯇᮏḠ୕㸧ࠕ㝸㞳㣫⫱ື≀ࣔࢹࣝ࠾ࡅࡿ࢚ࣆࢪ࢙ࢿࢸࢵࢡ࡞⢭⚄⚄⤒ᛶ㞀ᐖࡢⓎᶵ ᵓゎ᫂⸆≀㸦₎⸆㸧ไᚚࠖ80
8) ᖹᡂ26ᖺᗘ ₎་⸆Ꮫ⥲ྜ◊✲ᡤ ඹྠ⏝࣭ඹྠ◊✲ᣐⅬ㸪୍⯡◊✲ϩ㸦ᡤෆ௦⾲㸸 ᯇᮏḠ୕㸧ࠕ࣋ࢺࢼ࣒⏕⸆Acanthopanax gracilistylusW. W. Smithࡢᢠㄆ▱ຠᯝࡑࡢస
⏝ศᏊᶵᵓ㛵ࡍࡿᐇ㦂⸆⌮Ꮫⓗ◊✲ࠖ50
9) ᖹᡂ26ᖺᗘබ┈㈈ᅋἲே⏣ᮧ⛉Ꮫᢏ⾡⯆㈈ᅋ㸪」ྜ⸆≀⸆⌮Ꮫศ㔝 ᯇᮏḠ୕ ᩍᤵ
ᑐࡍࡿ◊✲⪅ᾏእὴ㐵ຓᡂࠕ17th World Congress of Basic and Clinical Pharmacology (WCP2014)ࠖ20
ۍ
ۍ◊◊✲ᐊᅾ⡠⪅
⸆Ꮫ㒊3ᖺ⏕㸸ᾏ⪁ἑ㸪ᮌᮧᜤᏊ
⸆Ꮫ㒊4ᖺ⏕㸸➉ᾈ⣖㸪ྜྷ⏣῟
⸆Ꮫ㒊5ᖺ⏕㸸ᫍ㔝㐶
Ꮫ㝔ಟኈ1ᖺ㸸㡑ᇁ⩚