ᑠᏳ㔜ኵ㸸៞ᛂ⩏ሿ኱Ꮫ ་Ꮫ㒊 ච␿Ꮫ

ࠕPI3࢟ࢼ࣮ࢮḞᦆ࣐࢘ࢫࢆ⏝࠸ࡓච␿Ꮫⓗ◊✲ࠖ

2004, 7㸫

4) ᐩỌ┿⍆㸸⮬↛⛉Ꮫ◊✲ᶵᵓ ⏕⌮Ꮫ◊✲ᡤ

ࠕࢭࣝࢭࣥࢧ࣮ศᏊ࡛࠶ࡿTRPࢳࣕࢿࣝࢆไᚚࡍࡿኳ↛⸆≀ࡢ᥈⣴࡜ࡑࡢ๰⸆ࣉࣟࢺࢱ

࢖ࣉ࡜ࡋ࡚ࡢ᭷⏝ᛶࡢ᳨ウࠖ

㸦࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ 2009ᖺᗘ㸪2010ᖺᗘ බເᆺඹྠ◊✲ ᥇ᢥㄢ㢟㸹⏕⌮Ꮫ◊

✲ᡤ 2010ᖺᗘ㸪2011ᖺᗘ ୍⯡ඹྠ◊✲ ᥇ᢥㄢ㢟㸧 2009, 7㸫

5) ຍ⸨ఙ୍㸸ி㒔⸆⛉኱Ꮫ ⑓ែ⸆⛉Ꮫ⣔ ⸆≀἞⒪Ꮫศ㔝

ᢠࡀࢇ๣㉳ᅉᛶ⭠⅖࡟ᑐࡍࡿ኱ᘓ୰‮㸪⣸ⱎ‮࠾ࡼࡧ㛵㐃᪉๣ࡢຠᯝ࡟㛵ࡍࡿ◊✲

㸦࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ 2012-2013ᖺᗘබເᆺඹྠ◊✲ ᥇ᢥㄢ㢟㸧 2012, 4㸫

6) Ύཎᐶ❶㸸໭㔛኱Ꮫ ໭㔛⏕࿨⛉Ꮫ◊✲ᡤ ࿴₎⸆≀Ꮫ

⭠⟶ච␿⣔࡟ᑐࡍࡿ₎᪉⸆ࡢస⏝ࡢゎᯒ࣭⿵୰┈Ẽ‮࡜ⴱ᰿‮ࢆ౛࡟ࡋ࡚

㸦࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ 2012ᖺᗘබເᆺඹྠ◊✲ ᥇ᢥㄢ㢟㸧 2012, 4㸫

7) ⚟஭ᐉつ㸸஑ᕞ኱Ꮫ ⏕య㜵ᚚ་Ꮫ◊✲ᡤ ච␿㑇ఏᏛศ㔝

ච␿ಟ㣭స⏝ࢆ᭷ࡍࡿ₎᪉⸆ࡢᶞ≧⣽⬊ᶵ⬟࡟ᑐࡍࡿస⏝ࡢゎ᫂

㸦࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ 2012ᖺᗘබເᆺඹྠ◊✲ ᥇ᢥㄢ㢟㸧 2012, 4㸫

8) ᒣᮏᐶ㸸⁠㈡་⛉኱Ꮫ እ⛉Ꮫㅮᗙ ᾘ໬ჾእ⛉

⭡㒊እ⛉ᡭ⾡࿘⾡ᮇ࡟࠾ࡅࡿ኱ᘓ୰‮ࡢຠᯝ

㸦࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ 2014ᖺᗘබເᆺඹྠ◊✲ ᥇ᢥㄢ㢟㸧 2014, 4㸫

ۍ

ۍ◊◊✲㈝ྲྀᚓ≧ἣ㻌

㻌 ¹⁾ ᖹᡂ26ᖺᗘ ᪥ᮏᏛ⾡᣺⯆఍⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲㸦C㸧௦⾲㸸ᒣᮏṊ

◊✲ㄢ㢟㸸ⴱ᰿‮ࡢ⢓⭷ච␿⣔࡛ࡢไᚚᛶT⣽⬊ㄏᑟ࡟ࡼࡿᢠ࢔ࣞࣝࢠ࣮ຠᯝ 㻌 ²⁾ ᖹᡂ26ᖺᗘ ᪥ᮏᏛ⾡᣺⯆఍⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲㸦C㸧௦⾲㸸㛛⬥┿

◊✲ㄢ㢟㸸ච␿ಟ㣭స⏝ࢆ᭷ࡍࡿ₎᪉⸆ࡢᶞ≧⣽⬊ᶵ⬟࡟ᑐࡍࡿస⏝ࡢゎ᫂࡜἞⒪ຠᯝ ࡢ⛉Ꮫⓗ᳨ド

㻌 ³⁾ ᖹᡂ26ᖺᗘ ᪥ᮏᏛ⾡᣺⯆఍⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲㸦B㸧ศᢸ㸸㛛⬥┿

◊✲ㄢ㢟㸸⸆⏝㈨※᳜≀ࡢከᵝᛶࢆ฼⏝ࡋࡓఏ⤫⸆ࡢỌ⥆ⓗ฼⏝ࣉࣟࢢ࣒ࣛࡢᵓ⠏

㻌 ⁴⁾㻌 _ᖹᡂ26ᖺᗘ ཌ⏕ປാ┬ ๰⸆ᇶ┙᥎㐍◊✲஦ᴗ ศᢸ㸸ᒣᮏṊ

◊✲ㄢ㢟㸸⸆⏝᳜≀᱂ᇵ୪ࡧ࡟㛵㐃⏘ᴗ᣺⯆ࢆᣦྥࡋࡓ⸆⏝᳜≀⥲ྜ᝟ሗࢹ࣮ࢱ࣮࣋ࢫ ࡢᣑ඘࡜᝟ሗᩚഛ࡟㛵ࡍࡿ◊✲㸦ᕝཎ⌜㸧

㻌 ⁵⁾ ᖹᡂ26ᖺᗘ Ꮫ㛗⿢㔞⤒㈝ⱝᡭ◊✲⪅ᨭ᥼⤒㈝ ௦⾲㸸ᯘ࿘స

◊✲ㄢ㢟㸸⭠⟶࣐ࢡࣟࣇ࢓࣮ࢪࡢᶵ⬟ไᚚࢆ௓ࡋࡓPI3Kp85Dࡢ⅖⑕ᛶ⭠⑌ᝈ࡟࠾ࡅࡿ⑓

ែ⏕⌮Ꮫⓗᙺ๭࡟㛵ࡍࡿ◊✲

㻌 ⁶⁾ ᖹᡂ26ᖺᗘ ㈈ᅋἲே ႚ↮⛉Ꮫ◊✲㈈ᅋ ௦⾲㸸㛛⬥┿ ศᢸ㸸ᯘ࿘స

◊✲ㄢ㢟㸸ච␿ᛂ⟅ኚ໬ࢆ௓ࡋࡓ₽⒆ᛶ኱⭠⅖ࡢⓎ⑕࡜ႚ↮㸫ᶞ≧⣽⬊࡛ࡢD7ᆺࢽࢥࢳ

ࣥཷᐜయࢆ௓ࡍࡿᢠ⅖⑕࣭ච␿స⏝ࡢศᏊ࣓࢝ࢽࢬ࣒ࡢゎ᫂㸫

㻌 ⁷⁾ ᖹᡂ26ᖺᗘ ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ බເᆺඹྠ◊✲㸦≉ᐃ◊✲㸧 ศᢸ㸸㛛⬥┿㸪ᯘ

࿘స

◊✲ㄢ㢟㸸ᩘ⌮ࣔࢹࣝ࠿ࡽ⣣ゎࡃ₎᪉⸆ࡢ」㞧⣔ືຊᏛࠥࠕᮍ⑓ࠖࡢ᳨ฟ࠿ࡽࡢ᪂ࡓ࡞

๰⸆࡟ྥࡅ࡚ࠥ

㻌 ⁸⁾ ᖹᡂ26ᖺᗘ ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ බເᆺඹྠ◊✲㸦୍⯡◊✲㸧 ศᢸ㸸㛛⬥ ┿㸪ᯘ

࿘స

◊✲ㄢ㢟㸸⭡㒊እ⛉ᡭ⾡࿘⾡ᮇ࡟࠾ࡅࡿ኱ᘓ୰‮ࡢຠᯝ 㻌

ۍ

ۍ◊◊✲ᐊᅾ⡠⪅㻌

㻌 ⸆ Ꮫ 㒊 3 ᖺ ⏕㸸❑㔝Ꮥ㈗

㻌 ⸆ Ꮫ 㒊 3 ᖺ ⏕㸸㔝ᕌ ᪫ 㻌 ⸆ Ꮫ 㒊 4 ᖺ ⏕㸸⣒஭ెዉ 㻌 ⸆ Ꮫ 㒊 4 ᖺ ⏕㸸⥴᪉⳹Ꮚ 㻌 ⸆ Ꮫ 㒊 5 ᖺ ⏕㸸ᑠ᳃ᏹḟ 㻌 ⸆ Ꮫ 㒊 5 ᖺ ⏕㸸ඵ௦ᬛỤ 㻌 ⸆ Ꮫ 㒊 6 ᖺ ⏕㸸ᯇ୪ᜨᮍ 㻌 ⸆ Ꮫ 㒊 6 ᖺ ⏕㸸ཎ ඃຍ 㻌 ኱Ꮫ㝔ಟኈ2ᖺ㸸℈⏣㈗அ

㻌 ኱Ꮫ㝔ಟኈ2ᖺ㸸Zhang Yue 㻌 ኱Ꮫ㝔༤ኈ1ᖺ㸸㛗⏣ኤె

㻌

ۍ

ۍᏛᏛ఩㸦ಟኈ㸪༤༤ኈ㸧ྲྀᚓ⪅㻌

㻌 ಟኈㄽᩥ

㻌 Putu Era Sandhi Kusuma Yuda :Role of CD206 Positive Macrophages in the Colonic Inflammation

㻌 ༤ኈㄽᩥ

㻌 㔠 ᚿὃ :Pathophysiological role of neuro-immune interaction between CGRP-containing enteric sensory neurons and mucosal mast cells in the development of food allergy and search for therapeutic agents against food allergy from Pakistani medicinal plants

⚄

⚄⤒ᶵ⬟Ꮫศ ศ㔝 Division of Neuromedical Science

෸ ᩍ ᤵ

ᮾ ⏣ ༓ ᑜ

$VVRFLDWH3URIHVVRU &KLKLUR7RKGD3K'

ຓ ᩍ

ஂಖᒣ཭ᬕ

$VVLVWDQW3URIHVVRU 7RPRKDUX.XER\DPD3K' 㻌

ۍ

ۍ◊◊✲┠ⓗ㻌

㻌 ᮏศ㔝࡛ࡣ㸪⚄⤒ᅇ㊰⥙ࡀ◚⥢ࡍࡿࡇ࡜࡟ࡼࡗ࡚ᶵ⬟୙඲ࡀ㐍⾜࠶ࡿ࠸ࡣỌ⥆ࡍࡿ㞴἞ᛶ⚄

⤒ኚᛶ⑌ᝈ㸦୺࡜ࡋ࡚࢔ࣝࢶࣁ࢖࣐࣮⑓㸪⬨㧊ᦆയ㸧ࢆࢱ࣮ࢤࢵࢺ࡜ࡋ࡚◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ

⚄⤒ᅇ㊰⥙◚⥢ࡢ࣓࢝ࢽࢬ࣒࡜㸪ࡑࢀࢆᨵၿࡉࡏࡿࢫࢺࣛࢸࢪ࣮ࡢ㘽࡜࡞ࡿ⏕యࡢศᏊ࣓࢝ࢽ ࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜࡛㸪⚄⤒ᅇ㊰⥙ࡀ◚⥢ࡋࡓᚋ࠿ࡽ࡛ࡶࡇࢀࡽ⑌ᝈ࡟࠾ࡅࡿ⚄⤒ᶵ⬟ࢆṇᖖ

࡟ᅇ᚟ࡉࡏࡿࡼ࠺࡞㸪᰿ᮏⓗ἞⒪ᡓ␎࡜ࡋ࡚ࡢ͆⚄⤒ᅇ㊰⥙෌ᵓ⠏⸆͇ࡢ㛤Ⓨࢆ┠ᣦࡋ࡚࠸ࡿࠋ

࢔ࣝࢶࣁ࢖࣐࣮⑓◊✲࡛ࡣ㸪ࣔࢹ࣐ࣝ࢘ࢫࡢグ᠈㞀ᐖࢆ㢧ⴭ࡟ᨵၿࡍࡿ₎᪉᪉๣ࡸ⏕⸆⏤᮶ ᡂศࢆぢฟࡋ࡚࠸ࡿࠋ⬨㧊ᦆയ◊✲࡟࠾࠸࡚ࡶ㸪ࣔࢹ࣐ࣝ࢘ࢫࡢ㐠ືᶵ⬟㞀ᐖࢆ㢧ⴭ࡟ᨵၿࡍ

ࡿ⸆≀ࢆ㸪ఏ⤫⸆≀ࡢゎᯒࢆࡶ࡜࡟Ⓨぢࡋ࡚ࡁࡓࠋࡲࡓ⌧ᅾ㸪ࡇࢀࡽఏ⤫⸆≀⏤᮶ࡢపศᏊ໬

ྜ≀࡟ࡼࡿ᪂ࡓ࡞ࢩࢢࢼࣜࣥࢢࡢゎᯒࢆ㸪⚄⤒ᅇ㊰⥙෌ᵓ⠏ࡢ㘽ࢆᥱࡿศᏊࢆゎ᫂ࡍࡿどⅬ࡛

㐍ࡵ࡚࠸ࡿࠋఏ⤫⸆≀⏤᮶ࡢ໬ྜ≀ࡸ㸪₎᪉᪉๣ࡢ㸪ከ㠃ⓗ࡛᪂ࡋ࠸స⏝ᶵᗎࡢゎ᫂࡟㸪ከᒙ

ⓗ࣭ືⓗᐇ㦂ᡭἲ࡛㏕ࡗ࡚࠸ࡿࠋ

ࡇࡢࡼ࠺࡟㸪ఏ⤫⸆≀◊✲࡜⚄⤒⛉Ꮫࢆ⼥ྜࡉࡏ㸪๰⸆࡜⑓ែゎᯒ࡬ᒎ㛤ࡉࡏࡿ⊂๰ⓗ࡛᭷

┈࡞࢔ࣉ࣮ࣟࢳ࡜ࡋ࡚ࠕఏ⤫⸆≀EDVHG๰⸆ࠖࢆᥦ᱌ࡋᐇ㊶ࡋ࡚࠸ࡿࠋ

ۍ

ۍ◊◊✲ᴫせ㻌

㻌 1) ୰ᯡ⚄⤒࡟࠾ࡅࡿ⚄⤒ࢿࢵࢺ࣮࣡ࢡ෌ᵓ⠏ࢆಁ㐍ࡍࡿศᏊᶵᗎࡢໟᣓⓗゎ᫂

2) ఏ⤫⸆≀EDVHG๰⸆࡟ࡼࡿ㸪࢔ࣝࢶࣁ࢖࣐࣮⑓࠾ࡼࡧ⬨㧊ᦆയ࡟ᑐࡍࡿ᰿ᮏⓗ἞⒪⸆ࡢ◊✲

3) ࢔ࣝࢶࣁ࢖࣐࣮⑓࠾ࡼࡧ⬨㧊ᦆയ࡟࠾࠸࡚㍈⣴෌⏕୙඲࡜࡞ࡿศᏊᶵᗎࡢゎ᫂

㻌㻌 㻌㻌

ۍ

ۍཎཎⴭㄽᩥ㻌

㻌 =KDQJ+<<DPDNDZD<0DWVX\D<7R\RRND17RKGD&$ZDOH6/L).DGRWD67H]XND

<6\QWKHVLVRIORQJFKDLQIDWW\DFLGGHULYDWLYHVDVDQRYHODQWL$O]KHLPHUVDJHQW %LRRUJDQLF 0HGLFLQDO&KHPLVWU\/HWWHUV

㻌 Watari H., Shimada Y., Tohda C.:1HZWUHDWPHQWIRU$O]KHLPHU¶VGLVHDVHNDPLNLKLWRUHYHUVHV amyloid-ß-induced progression of tau phosphorylation and axonal atrophy. Evidence-Based Complementary and Alternative Medicine. Volume 2014: Article ID 706487, 2014.

㻌 6KLJ\R07DQDEH1.XER\DPD7&KRL6+7RKGD&1HZUHOLDEOHVFRULQJV\VWHP7R\DPD 0RXVH6FRUHWRHYDOXDWHORFRPRWRUIXQFWLRQIROORZLQJVSLQDOFRUGLQMXU\LQPLFH%0&5HVHDUFK 1RWH

㻌 ۍ ۍ⥲ㄝ

㻌 ᮾ⏣༓ᑜ㸪ஂಖᒣ཭ᬕ㸸ఏ⤫⸆≀◊✲ࡀ⸆⌮Ꮫ࡟ࡶࡓࡽࡍ᪂ࡋ࠸どⅬ㸬᪥ᮏ⸆⌮Ꮫ㞧ㄅ㸬

㻌 .XER\DPD77RKGD&.RPDWVX.(IIHFWVRI$VKZDJDQGKDURRWVRIWithania somniferaRQ QHXURGHJHQHUDWLYHGLVHDVHV%LRO3KDUP%XO

㻌 ᮾ⏣༓ᑜ㸸⸆⏝᳜≀ࡢከᙬ࡞స⏝Ⅼࢆ᫂ࡽ࠿࡟ࡍࡿ̿᪂ࡋ࠸⸆ຠᶵᗎⓎぢ࡬ࡢ⣒ཱྀ̿㸬 ᐇ㦂་Ꮫ1HZV +RW3DSHU

⑓

⑓

ែ

ែ ไ ไ ᚚ ᚚ 㒊 㒊 㛛 㛛

病態制御部門

㻌 ۍ

ۍᏛ఍ሗ࿌

㸦㸦≉≉ูㅮ₇㸪㸪ࢩࢩ࣏ࣥࢪ࣒࢘㸪㸪࣮࣡࣡ࢡࢩࣙࢵࣉ➼㸧

㻖 1) ᮾ⏣༓ᑜ㸸 Improvement of memory function by traditional medicine in Alzheimer’s disease model mice㸬➨87ᅇ᪥ᮏ⸆⌮Ꮫ఍ᖺ఍㸪2014, 3, 19-21㸪௝ྎ.

㻖㻌 ²⁾ ᮾ⏣༓ᑜ㸸ఏ⤫⸆≀-based๰⸆㹼⚄⤒ኚᛶ⑌ᝈࡢ᪂἞⒪ᡓ␎ࢆᑟࡃ࢔ࣉ࣮ࣟࢳ㹼㸬ኳ↛⸆

≀◊✲᪉ἲㄽ࢔࢝ࢹ࣑࣮➨17ᅇᐩᒣࢩ࣏ࣥࢪ࣒࢘̿ኳ↛⸆≀࠿ࡽࡢ๰⸆̿㸬2014, 7, 26-27㸪ᐩᒣ㸬

㻖㻌 ³⁾ ᮾ⏣༓ᑜ㸸ᖹᡂ26ᖺᗘ࿴₎་⸆Ꮫ఍Ꮫ⾡㈉⊩㈹ཷ㈹ㅮ₇ࠕ࿴₎⸆◊✲ࡀᣅࡃ⚄⤒ኚᛶ⑌

ᝈࡢ᪂ࡋ࠸἞⒪ᡓ␎ࠖ㸬2014, 8, 31-9, 1㸪༓ⴥ㸬

㻌 ⁴⁾ Ώࡾⱥಇ㸪ᇳ⾜⨾ᬛᏊ㸪⏣㎶⣖⏕㸪ᮾ⏣㐨ஂ㸪Ki-Ho Cho㸪ᔱ⏣㇏㸪ᰘཎ┤฼㸪ஂಖᒣ཭

ᬕ㸪ᮾ⏣༓ᑜ㸸᪥ᮏ࠾ࡼࡧ㡑ᅜ࡛⏝࠸ࡽࢀ࡚࠸ࡿຍ࿡ᖐ⭁‮ࡢグ᠈ቑᙉస⏝ࡢẚ㍑㸬➨

31ᅇ࿴₎་⸆Ꮫ఍Ꮫ⾡኱఍㸪2014, 8, 30̽31㸪༓ⴥ㸬

㻌 ⁵⁾ Tanabe N., Kuboyama T., Kazuma K., Konno K., Tohda C.: The recovery of motor function by a crude drug and its active constituent in spinal cord injured mice. ➨37ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸪 2014, 9, 11 -13㸪ᶓ὾㸬

㻌 ⁶⁾ Yang Z., Kuboyama T., Tohda C.: DR improves memory impairment in Alzheimer’s disease model mice, 5XFAD, and attenuates amyloid β-induced axonal atrophy. ➨37ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸪 2014, 9, 11-13㸪ᶓ὾㸬

㻌 ⁷⁾ Shigyo M., Tanabe N., Kuboyama T., Choi S.-H., Tohda C.: New reliable scoring system, Toyama Mouse Score, to evaluate locomotor function following spinal cord injury in mice. ➨37ᅇ᪥ᮏ

⚄⤒⛉Ꮫ኱఍㸪2014, 9, 11-13㸪ᶓ὾.

㻌 ⁸⁾ Kuboyama T., Lee Y.-A., Nishiko H., Tohda C.: Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced growth cone collapse, axonal atrophy and memory impairment. ➨37 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸪2014, 9, 11-13㸪ᶓ὾㸬

㻌 ⁹⁾ Tohda C., Lee Y.-A., Goto Y., Nemere I.: Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS. ➨37ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸪2014, 9, 11-13㸪ᶓ὾.

㻌 ¹⁰⁾ ⏣㎶⣖⏕㸪ஂಖᒣ཭ᬕ㸪ᩘ㤿ᜏᖹ㸪⤃㔝຾ᘯ㸪ᮾ⏣༓ᑜ㸸ᛴᛶᮇ࠾ࡼࡧ៏ᛶᮇ⬨㧊ᦆയ࡟

࠾࠸࡚㐠ືᶵ⬟ᨵၿࢆಁࡍ⏕⸆࡜ࡑࡢάᛶᡂศࡢ◊✲㸬➨13ᅇḟୡ௦ࢆᢸ࠺ⱝᡭࣇ࢓࣮

࣐ࣂ࢖࢜ࣇ࢛࣮࣒ࣛ2014㸪2014, 9, 20-21㸪ᐩᒣ㸬

㻌 ¹¹⁾ Shigyo M., Kuboyama T., Tohda C.: Extracellular vimentin promotes axonal growth via IGF1R.

➨13ᅇḟୡ௦ࢆᢸ࠺ⱝᡭࣇ࢓࣮࣐ࣂ࢖࢜ࣇ࢛࣮࣒ࣛ2014㸪2014, 9, 20-21㸪ᐩᒣ㸬 㻌 ¹²⁾ ᇳ⾜⨾ᬛᏊ㸪ஂಖᒣ཭ᬕ㸪ᮾ⏣༓ᑜ㸸⣽⬊እvimentinࡣIGF1Rࢆ௓ࡋ࡚㍈⣴ఙᒎࢆಁ㐍

ࡍࡿ㸬➨36ᅇ᪥ᮏ⏕≀Ꮫⓗ࣭⢭⚄་Ꮫ఍➨57ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ྜྠᖺ఍㸪2014, 9, 29-10, 1㸪ዉⰋ㸬

㻌 ¹³⁾ Watari H., Shimada Y., Tohda C.: Aspartate aminotransferase is a direct target protein of kamikihito and mediates the anti-Alzheimer’s disease effect. The 17th International Congress of Oriental Medicine. 2014, 11, 1-3, Taipei, Taiwan.

㻌 ¹⁴⁾ Tanabe N., Kuboyama T., Kazuma K., Konno K., Tohda C.: Improvement of motor dysfunction in acute and chronic phases in spinal cord injury mice by a crude drug-derived compound. Society for Neuroscience 44th Annual Meeting (Neuroscience 2014) 2014, 11, 15-19, Washington DC, USA.

㻌 ¹⁵⁾ Yang Z., Kuboyama T., Tohda C.: DR-induced cognitive enhancement in Alzheimer’s disease model mice, 5XFAD, and underlying mechanisms. Society for Neuroscience 44th Annual Meeting (Neuroscience 2014) 2014, 11, 15-19, Washington DC, USA.

㻌 ¹⁶⁾ Shigyo M., Kuboyama T., Tohda C.: Extracellular vimentin promotes axonal growth via IGF1R.

Society for Neuroscience 44th Annual Meeting (Neuroscience 2014) 2014, 11, 15-19, Washington DC, USA.

㻌 ¹⁷⁾ Kuboyama T., Lee Y.-A., Nishiko H., Tohda C.: Clathrin-mediated endocytosis is a key target for amyloid β-induced axonal degeneration and memory impairment. Society for Neuroscience 44th Annual Meeting (Neuroscience 2014) 2014, 11, 15-19, Washington DC, USA.

㻌 ¹⁸⁾ Tohda C., Yang X., Lee Y.-A., Goto Y., Nemere I.: The mechanism of diosgenin-induced cognitive

enhancement in Alzheimer̓s disease model mice and normal mice. Society for Neuroscience 44th Annual Meeting (Neuroscience 2014) 2014, 11, 15-19, Washington DC, USA.

㻌 ᣍ ᣍᚅㅮ₇

㻖㻌 ¹⁾ Tohda C.: Traditional Medicine-based Drug Development: our approach to new therapeutic strategies for neurodegenerative diseases. The 14th International Symposium on Traditional Medicine in Toyama 2014. 2014, 10, 27-28, Toyama.

㻖㻌 2) Tohda C.: ໭ி኱Ꮫ̿ᐩᒣ኱ᏛᣐⅬ㛫஺ὶㅮ₇఍ࠕNatural medicine study aiming to explore therapeutic strategies for neurodegenerative diseasesࠖ㸪2014, 3, 10㸪໭ி㸬

㻖㻌 3) ஂಖᒣ཭ᬕ㸸࢔࣑ࣟ࢖ࢻβ࡟ࡼࡿ㍈⣴ኚᛶᶵᗎࡢゎ᫂㸬ᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ࣭

㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᡤ ➨4ᅇ஺ὶࢭ࣑ࢼ࣮㸪2014, 12, 8㸪ᐩᒣ㸬 㻌

ۍ ۍࡑࡑࡢ௚

ࡑ

ࡑࡢ௚ࡢㅮ₇

㻌 1) ᮾ⏣༓ᑜ㸸NPO ἲேᐩᒣࡢࡃࡍࡋ ₎᪉་Ꮫ࡜⏕⸆ㅮᗙࠕ⬨㧊ᦆയ࡜࿴₎⸆ࠖ㸪2014, 2, 15㸪ᐩᒣ㸬

㻌 2) ᮾ⏣༓ᑜ㸸࢔ࣝࢶࣁ࢖࣐࣮⑓࡟᭷ຠ࡞₎᪉ฎ᪉㸦ᖐ⭁‮㸧㸬₎᪉⸆࣭⏕⸆⸆๣ᖌㅮᗙ㸪2014, 7, 27㸪ᮾி㸬

㻌 3) ஂಖᒣ཭ᬕ㸸⚄⤒ኚᛶ⑌ᝈ࡟᭷ຠ࡞ఏ⤫⸆≀ࢆồࡵ࡚㸬➨19ᅇᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ

◊✲ᡤኟᮇࢭ࣑ࢼ࣮㸪2014, 8, 21㸪ᐩᒣ㸬

㻌 4) ᮾ⏣༓ᑜ㸸ᐩᒣ኱ᏛᕷẸㅮᗙࠕఏ⤫⸆≀◊✲ࡀᣅࡃ⚄⤒ኚᛶ⑌ᝈඞ᭹࡬ࡢᕼᮃࠖ㸪2014, 10, 4㸪ᐩᒣ㸬

㻌

ཷ

ཷ㈹㻌㻌

㻌 1) ᮾ⏣༓ᑜ㸸ᖹᡂ26ᖺᗘ࿴₎་⸆Ꮫ఍Ꮫ⾡㈉⊩㈹ࠕ࿴₎⸆◊✲ࡀᣅࡃ⚄⤒ኚᛶ⑌ᝈࡢ᪂ࡋ

࠸἞⒪ᡓ␎ࠖ㸪2014, 8, 31-9,1㸪༓ⴥ㸬 㻌

᪂ ᪂⪺ググ஦

㻌 1) ࠕࣜࢣࢪࣙ⭾ࡽࡴክࠖ㸬໭᪥ᮏ᪂⪺㸦ᮅห㸧㸹2014, 2, 1.

㻌 2) ᩍ⫱2014 ₎᪉⸆࡟⏕ࡁࡿࠕ࢔ࣝࢶࣁ࢖࣐࣮⑓᏶἞┠ᶆࠖ㸬ᮅ᪥᪂⪺㸦ᮅห㸧㸹2014, 6, 30.

㻌 3㸧 ఏ⤫⸆≀グ᠈㞀ᐖ࡟ᕼᮃᐩᒣ኱ᕷẸㅮᗙᮾ⏣෸ᩍᤵࡀㅮ₇㸬ㄞ኎᪂⪺㸦ᮅห㸧㸹2014, 10, 5.

㻌 4) ᐩᒣ኱ᏛᕷẸㅮᗙ➨4ᅇ ㄆ▱⑕⸆㛤Ⓨ࡟ᕼᮃ㸬ㄞ኎᪂⪺㸦ᮅห㸧㸹2014, 10, 10.

㻌

≉

≉チ

㻌 1) ᮾ⏣༓ᑜ㸪ᯇ㇂⿱஧㸪ᮡᮏ೺ኈ㸸≉㢪2014-091718, 2014, 4, 25.

㻌 2) ᮾ⏣༓ᑜ㸪኱㔝ᮌᏹ㸸≉㢪2014-102633, 2014, 5, 16.

㻌 3) ᮾ⏣༓ᑜ㸪ஂಖᒣ཭ᬕ㸪᳿ᚿ཭㸸≉㢪2014-136176, 2014, 7, 1.

㻌 4) ᮾ⏣༓ᑜ㸪ஂಖᒣ཭ᬕ㸪⏣㎶⣖⏕㸸≉㢪2014-157268, 2014, 8, 1.

㻌 ۍ

ۍඹඹྠ◊✲㻌

㻌 ¹⁾ ᑠᯇ࠿ࡘᏊ㸸ᐩᒣ኱Ꮫ㸪ࠕ⚄⤒ኚᛶ⑌ᝈ࡟᭷ຠ࡞ఏ⤫⸆≀ศᏊࡢ᥈⣴࡜ࡑࡢ἞⒪ᡓ␎ࠖ

㻌 2㸧 ᯇ㇂⿱஧㸸ᐩᒣ኱Ꮫ㸪ࠕwithanolide㢮ࡢ◊✲ࠖࠕ᪂つ໬ྜ≀ࡢ⚄⤒ಖㆤస⏝ࡢ◊✲ࠖ

㻌 ³⁾ ᱵᔘ㞞ே㸸ᐩᒣ኱Ꮫ㸪ࠕ⏕⸆ᡂศࡢ⸆ຠᶵᵓࡢゎ᫂ࠖ

㻌 ⁴⁾ ⤃㔝຾ᘯ㸸ᐩᒣ኱Ꮫ㸪ࠕᐩᒣ┴⏘࿴₎⸆࠿ࡽ㛤Ⓨࡍࡿ⬨㧊ᦆയᨵၿ⸆࡟㛵ࡍࡿ◊✲ࠖ

㻌 ⁵⁾ 㛵㇂೔Ꮚ㸪㣤ᓥᾈ୍㸸ᅜ❧㛗ᑑ་⒪◊✲ࢭࣥࢱ࣮㸪ࠕ࿴₎⸆ࡢᶆⓗศᏊࡢ⥙⨶ⓗゎᯒ࠾ࡼ

ࡧໟᣓⓗస⏝࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠖ

㻌 ⁶⁾ ୖᒣ೺ᙪ㸸⚄ᡞ኱Ꮫࣂ࢖࢜ࢩࢢࢼࣝ◊✲ࢭࣥࢱ࣮㸪ࠕྛ✀ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࢆ⏝࠸ࡓ⬨

㧊ᦆയ࡟࠾ࡅࡿ࢔ࢫࢺࣟࢧ࢖ࢺࡢᶵ⬟ゎᯒࠖ

㻌 ⁷⁾ 㓇஭㝯୍㸸໭ᾏ㐨኱ᏛỈ⏘⛉Ꮫ◊✲㝔㸪ࠕ࢔ࣝࢶࣁ࢖࣐࣮⑓ࡢグ᠈㞀ᐖࢆᨵၿࡍࡿᾏὒኳ

↛≀ࡢ᥈⣴ࠖ

㻌 ⁸⁾ ୖཱྀ⿱அ㸸⌮໬Ꮫ◊✲ᡤ㸪ࠕ㍈⣴෌⏕୙඲ࡢᶵᗎࢆゎ᫂ࡍࡿࡓࡵࡢ◊✲ࠖ

㻌 ۍ

ۍ◊◊✲㈝ྲྀᚓ≧ἣ㻌

㻌 ¹⁾ ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠㸪ᣮᡓⓗⴌⱆ㸦௦⾲㸸ᮾ⏣༓ᑜ㸪ศᢸ㸸⤃㔝຾ᘯ㸪ᩘ㤿ᜏᖹ㸪㐃 ᦠ㸸ஂಖᒣ཭ᬕ㸧ࠕఏ⤫⸆≀ࢆ࣮࣋ࢫ࡜ࡋࡓ๰⸆̿᪂ࡋ࠸ࣃࣛࢲ࢖࣒ࡢ๰⏕̿ࠖ

㻌 ²⁾ ᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ ඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ ≉ᐃ◊✲㸦௦⾲㸸㛵㇂೔Ꮚ㸪

⤫ᣓ㸸ᮾ⏣༓ᑜ㸪ศᢸ㸸ஂಖᒣ཭ᬕ㸪㣤ᓥᾈ୍㸧ࠕ࿴₎⸆ࡢᶆⓗศᏊࡢ⥙⨶ⓗゎᯒ࠾ࡼࡧ ໟᣓⓗస⏝࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠖ

㻌 ³⁾ ᐩᒣ኱ᏛᏛ㛗⿢㔞⤒㈝ዪᛶ◊✲⪅࣮ࣜࢲ࣮ࢩࢵࣉ⫱ᡂຓᡂ㸦௦⾲㸸ᮾ⏣༓ᑜ㸧ࠕ⬨㧊ᦆ യཷയᚋ៏ᛶᮇ࠿ࡽࡢᶵ⬟ᅇ᚟ࢆᐇ⌧ࡍࡿ᪂つ἞⒪⸆ࡢ๰ฟࠖ

㻌 ⁴⁾ ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠㸪ᇶ┙◊✲Bᾏእ㸦ศᢸ㸸ᮾ⏣༓ᑜ㸧ࠕ⸆⏝㈨※᳜≀ࡢከᵝᛶࢆ

฼⏝ࡋࡓఏ⤫⸆ࡢỌ⥆ⓗ฼⏝ࣉࣟࢢ࣒ࣛࡢᵓ⠏ࠖ

㻌 5㸧 ཌ⏕ປാ⛉Ꮫ◊✲஦ᴗ㸦ศᢸ㸸ᮾ⏣༓ᑜ㸧ࠕ⸆⏝᳜≀᱂ᇵ୪ࡧ࡟㛵㐃⏘ᴗ᣺⯆ࢆᣦྥࡋࡓ

⸆⏝᳜≀⥲ྜ᝟ሗࢹ࣮ࢱ࣮࣋ࢫࡢᣑ඘࡜᝟ሗᩚഛ࡟㛵ࡍࡿ◊✲ࠖ

⁶⁾ ୖཎグᛕ⏕࿨⛉Ꮫ㈈ᅋ ◊✲ዡບ㔠㸦௦⾲㸸ஂಖᒣ཭ᬕ㸧ࠕ」ྜ⸆≀ࡢࡓࡵࡢໟᣓⓗ⸆⌮

స⏝ゎᯒἲࡢ㛤Ⓨࠖ

⁷⁾ ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠㸪᪂Ꮫ⾡㡿ᇦ◊✲㸦㐃ᦠ㸸ஂಖᒣ཭ᬕ㸧ࠕ⤫ྜⓗ⚄⤒ᶵ⬟ࡢไᚚ

ࢆᶆⓗ࡜ࡋࡓ⢾㙐ࡢసືཎ⌮ゎ᫂ࠖ

⁸⁾ ᐩᒣ኱ᏛᏛ㛗⿢㔞⤒㈝ ⱝᡭ◊✲⪅ᨭ᥼⤒㈝㸦௦⾲㸸ஂಖᒣ཭ᬕ㸧ࠕࢱ࣮ࢤࢵࢺศᏊࡢ⥙

⨶ⓗゎᯒ࡟ࡼࡿ₎᪉⏕⸆ࡢศᏊ⸆⌮Ꮫⓗᇶ┙ࡢᵓ⠏ࠖ

ۍ

ۍ◊◊✲ᐊᅾ⡠⪅

㻌 Ꮫ 㒊 3 ᖺ ⏕㸸▼ᕝ༟㸪ᑠᬽᬛ㔛

㻌 Ꮫ 㒊 4 ᖺ ⏕㸸ᕤ⸨ฑ⣪㸪㇂ỤⰋᓫ㸪᳿⇊ⵚ 㻌 ኱Ꮫ㝔ಟኈ2ᖺ㸸⏣㎶⣖⏕

㻌 ኱Ꮫ㝔༤ኈ2ᖺ㸸ᇳ⾜⨾ᬛᏊ

㻌 ኱Ꮫ㝔༤ኈ1ᖺ㸦2014, 9, 30ࡲ࡛㸧̿2ᖺ㸦2014, 10, 1ࡼࡾ㸧㸸᳿ᚿ཭

㻌 ὴ㐵኱Ꮫ㝔༤ኈ4ᖺ㸸Ώࡾⱥಇ㸦ᐩᒣ኱Ꮫ་Ꮫ㒊࣭࿴₎デ⒪Ꮫ㸪2010, 10ࡼࡾ㸧

ᰤ

ᰤ㣴௦ㅰᏛศ㔝 Division of Nutritional Biochemistry

෸ ᩍ ᤵ

Ώ㎶ᚿᮁ

Associate Professor Shiro Watanabe (Ph.D.)

ຓ ᩍ

⸨⏣ᜤ㍜

Assistant Professor Kyosuke Fujita (Ph.D.)

ۍ

ۍ◊✲┠ⓗ

࿴₎⸆㸪≉࡟ື≀⫹Ồ⏤᮶⫹Ồ㓟ࡢ᪂ࡋ࠸⬡㉁௦ㅰไᚚᶵ⬟ࢆぢฟࡋ㸪ࡑࢀࢆ⑌ᝈࡢண㜵࣭἞

⒪࡟ά⏝ࡍࡿࡇ࡜ࢆ┠ᣦࡍࠋ

ۍ

ۍάάືᴫせ

㸯

㸯㸧㸧⬡⬡㉁ࡢ⥙⨶ⓗศᯒࢆ⏝⏝࠸ࡓ࿴₎⸆࡞ࡽࡧ࡟ኳ↛⏤᮶ᡂศࡢ⬡⬡㉁௦ㅰไᚚάάᛶࡢゎᯒ

⬡⫫㓟ࣉࣟࣇ࢓࢖ࣜࣥࢢ࠿ࡽ㸪ື≀⫹࠾ࡼࡧࡑࡢ୺ᡂศ࡛࠶ࡿ⫹Ồ㓟ࡢ⬡㉁௦ㅰ࡟ཬࡰࡍᙳ㡪

ࢆ᫂ࡽ࠿࡟ࡋࡓࠋࡇࡢศᏊᶵᵓࢆ⫹Ồ㓟ࡢ᰾ෆ࠾ࡼࡧ⣽⬊⾲㠃ཷᐜయ࡬ࡢస⏝ࡢほⅬ࠿ࡽゎ᫂

ࡍࡿࠋ 㸰

㸰㸧㸧⫹⫹Ồ㓟ࡀࡀ㛵୚ࡍࡿ⬡㉁௦ㅰ␗␗ᖖࡢࡢไᚚ࡟㛵ࡍࡿ◊✲

ࢥ࣮ࣝ㓟㈇Ⲵ࡟ࡼࡗ࡚ㄏᑟࡉࢀࡿ⫢㞀ᐖࣔࢹࣝ࡟ᑐࡍࡿ㜵ᕬ㯤⪆‮ࡢ㜵ᚚస⏝ࢆ᫂ࡽ࠿࡟ࡋ ࡓࠋࡇࡢຠᯝࡢศᏊᶵᵓࢆ⬡㉁௦ㅰࡢほⅬ࠿ࡽゎ᫂ࡍࡿࠋ

ۍ

ۍཎཎⴭㄽᩥ㻌

1) Yamawaki H., Mihara H., Suzuki N., Nishizono H., Uchida K., Watanabe S., Tominaga M., Sugiyama T.: Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage. Am J Physiol Gastrointest Liver Physiol. 307:G33-40. 2014.

2) Watanabe S., Fujita K.: Dietary hyodeoxycholic acid exerts hypolipidemic effects by reducing farnesoid X receptor antagonist bile acids in mouse enterohepatic tissues. Lipids 49, 963-973, 2014.

ۍ

ۍᏛᏛ఍ሗ࿌ 㸦㸦㻖㻖㻦㻌≉≉ูㅮ₇㸪ࢩ࣏ࣥࢪ࣒࢘㸪࣮࣡ࢡࢩࣙࢵࣉ➼㸧㻌㻌

1) ᮤᓠ㸪⏣୰ㅬ㸪Ώ㎶ᚿᮁ㸪ᡭሯᗣᘯ㸸Monoterpenoid Glucoindole Alkaloids from the Roots of Dipsacus asper.᪥ᮏ⸆Ꮫ఍➨134ᖺ఍㸪2014, 3, 27-30㸪⇃ᮏ㸬

2) Ώ㎶ᚿᮁ㸪⸨⏣ᜤ㍜㸸⬡⫫㓟ᵓᡂࡢ⥙⨶ⓗศᯒ࡟ࡼࡿࢥ࣮ࣝ㓟ㄏⓎᛶ⫢㞀ᐖ࡜ࡑࡢ㜵ᕬ 㯤⪆‮࡟ࡼࡿ㍍ῶࡢᶵᵓゎᯒ㸬➨31ᅇ࿴₎་⸆Ꮫ఍Ꮫ⾡኱఍㸪2014, 8, 30-31㸪༓ⴥ㸬 3) Niu Yimin, Li Feng, Hironori Fujiwara, Ken Tanaka, Shiro Watanabe, Sachie Sasak-Hamada,

Jun-Ichiro Oka, Kinzo Matsumoto.: Chemical profiling of endogenous and exogenous markers of chitosan in an animal medel of diabetes. ➨31ᅇ࿴₎་⸆Ꮫ఍Ꮫ⾡኱఍㸪2014, 8, 30-31㸪༓ⴥ㸬 4) ⸨⏣ᜤ㍜㸪ᯇᕝᚁஓ㸪஭ୖಇ㸪Ώ㎶ᚿᮁ㸸ࣄ࢜ࢹ࢜࢟ࢩࢥ࣮ࣝ㓟࠾ࡼࡧ࢘ࣝࢯࢹ࢜࢟ࢩࢥ

࣮ࣝ㓟ࡢ⫢⮚୰ࢺࣜࢢࣜࢭࣜࢻྵ㔞పୗస⏝㸬➨87ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍㸪2014, 10, 15-18 㸪ி㒔㸬

5) Ώ㎶ᚿᮁ㸪⸨⏣ᜤ㍜㸸࣐࢘ࢫ࡟࠾ࡅࡿࣄ࢜ࢹ࢜࢟ࢩࢥ࣮ࣝ㓟࡜࢘ࣝࢯࢹ࢜࢟ࢩࢥ࣮ࣝ㓟 ࡢ⬡㉁పୗస⏝ࡢẚ㍑㸬➨36ᅇ⫹Ồ㓟◊✲఍㸪2014, 11, 29㸪ᮾி㸬

6) ᯇᮏḠ୕㸪∵୍Ẹ㸪✄⏣༓㤶Ꮚ㸪⸨ཎ༤඾㸪ᮤᓠ㸪⏣୰ㅬ㸪Ώ㎶ᚿᮁ㸪὾⏣ᖾᜨ㸪ᒸ῟୍

㑻㸸㔮⸨ᩓᢞ୚࡟ࡼࡾ⬻ෆ࡟ฟ⌧ࡍࡿ⏕⸆⏤᮶ศᏊ࡜⏕యෆศᏊ㸸2ᆺ⢾ᒀ⑓ࣔࢹ࣐ࣝ࢘

⑓

⑓

ែ

ែ ไ ไ ᚚ ᚚ 㒊 㒊 㛛 㛛

病態制御部門

ࢫ࡛ࡢex vivoࢣ࣑࢝ࣝࣉࣟࣇ࢓࢖ࣜࣥࢢゎᯒ㸬➨13ᅇ᪥ᮏ⮫ᗋ୰་⸆Ꮫ఍Ꮫ⾡኱఍

7) ᯘᛅ⣫㸪Ⲩဴஓ㸪࿴⏣⠜ᩗ㸪⸨⏣ᜤ㍜㸪Ώ㎶ᚿᮁ㸸኱ᰘ⬌‮ࡢᢠ⫧‶స⏝ࡢ᳨ウ㸬᪥ᮏ

⏕⸆Ꮫ఍➨61ᖺ఍㸪2014, 9, 13-14㸪⚟ᒸ㸬

ۍ

ۍඹඹྠ◊✲

1) ௒୰ᖖ㞝㸸ᐩᒣ኱Ꮫ኱Ꮫ㝔་Ꮫ⸆Ꮫ◊✲㒊⸆Ꮫ㸪ࠕ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮࡟࠾ࡅࡿ࣌

ࣝ࢜࢟ࢩࢰ࣮࣒ᴟ㛗㙐⬡⫫㓟௦ㅰࡢ␗ᖖࡢᶵᵓゎ᫂࡟㛵ࡍࡿ◊✲ࠖ

2) ᑠᯘ〇⸆ࠕ኱ᰘ⬌‮ࡢᢠ⫧‶ຠᯝ࡟࠾ࡅࡿ⬡㉁௦ㅰࡢᙺ๭ࡢゎᯒࠖ

3) ᖖᒣᖾ୍㸸ᐩᒣ኱Ꮫ኱Ꮫ㝔་Ꮫ⸆Ꮫ◊✲㒊་Ꮫ㸪ࠕ762' ࣐࢘ࢫ࡟࠾ࡅࡿ⬡⫫⫢࡟ᑐࡍ

ࡿ⫹Ồ㓟ࡢᙳ㡪࡟㛵ࡍࡿ◊✲ࠖ

4) ᒣᮏ㞞๎㸸ᒸᒣ┴ຍ㈡㒆ྜྷഛ୰ኸ⏫ࠕ⊦⏤᮶⫹Ồࡢᛶ⬟ホ౯ࠖ

ۍ

ۍ㠀ᖖ໅ㅮᖌ

1) Ώ㎶ᚿᮁ㸸ᐩᒣ┴❧኱ᏛᕤᏛ㒊ࠕ⣽⬊ᕤᏛࠖ2014, 5-6.

ۍ

ۍ◊◊✲㈝ྲྀᚓ≧ἣ

ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝㸪ᇶ┙◊✲(C)㸦௦⾲㸸Ώ㎶ᚿᮁ㸧ࠕ㜵ᕬ㯤⪆‮ࡣPXRࢆάᛶ໬ࡍ

ࡿࡇ࡜࡟ࡼࡗ࡚ᐇ㦂ⓗ⫹Ồ࠺ࡗᆺ⫢⑌ᝈࢆᨵၿࡍࡿ࠿?ࠖ140୓෇

ۍ

ۍ◊◊✲ᐊᅾ⡠⪅

⸆Ꮫ㒊⸆Ꮫ⛉3ᖺ⏕㸸㎷ဴஓ

⸆Ꮫ㒊⸆Ꮫ⛉6ᖺ⏕㸸ᯇᕝṇஓ㸪஭ୖಇ

₎

₎᪉デ᩿Ꮫศ ศ㔝 Division of Kampo Diagnostics

㻌

ᩍ ᤵ

ᰘཎ ┤฼

Professor Naotoshi Shibahara (M.D., Ph.D.)

෸ ᩍ ᤵ

ᑠἨ ᱇୍

Associate Professor Keiichi Koizumi (Ph.D.)

ຓ ᩍ

᮲ ⨾ᬛᏊ

Assistant Professor Michiko Jo (Ph.D.) ᢏ⾡⿵బဨ

ᮌᮧ ┿᲍

Assistant Mari Kimura (Ph.D.) ᢏ⾡⿵బဨ

≟ᔲ ᫂Ꮚ

Assistant Akiko Inujima ᢏ⾡⿵బဨ

ᒾⓑ ෇

Assistant Madoka Iwashiro 㻌

ۍ

ۍ◊◊✲┠ⓗ㻌

㻌 ₎᪉⸆ࡣᵝࠎ࡞⑌ᝈࡢ἞⒪࡟࠾࠸࡚ᖜᗈࡃ౑⏝ࡉࢀ࡚࠾ࡾ㸪៏ᛶ࠶ࡿ࠸ࡣ㞴἞ᛶ⑌ᝈ࡟࠾ࡅࡿ

₎᪉⸆࡟ࡼࡿ἞⒪ཬࡧ㐍ᒎண㜵ຠᯝ࡬ࡢᮇᚅࡶ኱ࡁ࠸ࠋࡑࡢ୍᪉࡛㸪₎᪉་Ꮫࡣ⤒㦂ⓗ࡛࠶ࡿ

࡜ࡢᢈุࡶ࠶ࡾ㸪⮫ᗋ◊✲ࡸᇶ♏◊✲ࢆ㏻ࡋࡓ⛉Ꮫⓗ࢚ࣅࢹࣥࢫࡢ⵳✚ࡀồࡵࡽࢀ࡚࠸ࡿࠋ࢚

ࣅࢹࣥࢫࡢ⵳✚࡟ࡣ㸪₎᪉་Ꮫⓗᴫᛕࡸド㸦㐺ᛂ⑓ែ㸧ࡢᐈほ໬ࡍࡿ࡜࡜ࡶ࡟㸪₎᪉⸆ࡢ⸆⌮

ຠᯝࡸస⏝ᶵᗎࢆゎ᫂ࡍࡿࡇ࡜࡟ࡼࡾ㸪₎᪉་⸆Ꮫࢆᬑ㐢ⓗ࡞ࡶࡢ࡜ࡍࡿᚲせ࡛࠶ࡿࠋࡑࡇ࡛㸪 ᮏศ㔝ࡣ㸪₎᪉་Ꮫⓗ⑓ែࡸ₎᪉⸆ࡢ἞⒪ຠᯝ࡟㛵ࡍࡿ⮫ᗋ◊✲࡜㸪ᐇ㝿ࡢ⮫ᗋ࡛ࡢ₎᪉⸆౑

⏝≧ἣࢆ⪃៖ࡋࡓᇶ♏◊✲࡟ࡼࡾ㸪᪂ࡓ࡞₎᪉་Ꮫࢆ☜❧ࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚࠸ࡿࠋ ۍ

ۍ◊◊✲ᴫせ 㻌 Ϩ

Ϩ㸧㸧₎₎᪉᪉๣࣭⏕⸆ࡢ⸆⌮ຠᯝࡢᇶ♏ⓗ◊✲

㻌 1) ᾋ⭘࣭៏ᛶ⭈⮚⑓࣭⢾ᒀ⑓࡟ᑐࡍࡿ₎᪉᪉๣࣭⏕⸆ࡢຠᯝ 2) ₎᪉᪉๣࣭⏕⸆ࡢ⢓⭷ච␿άᛶຠᯝ

3) ₎᪉᪉๣࣭⏕⸆ࡢ⢓⭷࣡ࢡࢳࣥ࢔ࢪࣗࣂࣥࢺຠᯝ 5) ₎᪉᪉๣࣭⏕⸆ᡂศࡢ⏕యෆືែゎᯒ

6) ₎᪉᪉๣ࡢཤຍ᪉࡟㉳ᅉࡍࡿຠᯝࡢኚ໬

7) ⏕⸆ࡢရ㉁࡟ࡼࡿຠᯝⓎ⌧ࡢኚ໬

8) ⓶⭵ಖ‵ᛶ࣭ಖ ᛶ࡟ᑐࡍࡿຠᯝ ϩ

ϩ㸧㸧ドドࡢ⛉Ꮫⓗ⩻ヂ࡟㛵ࡍࡿ⮫ᗋⓗ◊✲

㻌 1) ₎᪉་Ꮫⓗ⑓ែࡢᩘ್໬

2) ⮬ᚊ⚄⤒⣔࡜₎᪉་Ꮫⓗ⑓ែ࡜ࡢ㛵㐃ᛶ 3) ࢫࢺࣞࢫᑐᛂ₎᪉᪉๣ࡢ⸆⌮ຠᯝ 4) ྛ✀⑌ᝈ࡟ᑐࡍࡿ⮫ᗋຠᯝ Ϫ

Ϫ㸧㸧₎₎᪉་⸆Ꮫ◊ಟ࡟㛵ࡍࡿ◊✲

㻌 1) ᩍ⫱ຠᯝ࡟㛵ࡍࡿ᳨ウ

2) ₎᪉་⸆Ꮫ◊ಟࣉࣟࢢ࣒ࣛࡢ㛤Ⓨ

㻌 ۍ

ۍཎⴭㄽᩥ 㻌㻌

㻌㻌 1) Andoh T., Kitamura R., Fushimi H., Komatsu K., Shibahara N., Kuraishi Y.: Effects of goshajinkigan, hachimijiogan, and rokumigan on mechanical allodynia induced by Paclitaxel in

⮫

⮫ ᗋ ᗋ

฼

฼

⏝

⏝ 㒊 㒊 㛛 㛛

臨床利用部門

mice. J Tradit Complement Med., 4: 293-297, 2014.

㻌㻌 2) Watari H., Shigyo M., Tanabe N., Tohda M., Cho K. H., Kyung P. S., Jung W. S., Shimada Y., Shibahara N., Kuboyama T., Tohda C.: Comparing the Effects of Kamikihito in Japan and Kami-Guibi-Tang in Korea on Memory Enhancement: Working Towards the Development of a Global Study. Phytother Res., doi: 10.1002/ptr.5250, 2014.

㻌 3) Kee J. Y., Ito A., Hojo S., Hashimoto I., Igarashi Y., Tsuneyama K., Tsukada K., Irimura T., Shibahara N., Takasaki I., Inujima A., Nakayama T., Yoshie O., Sakurai H., Saiki I., Koizumi K.:

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages. BMC Cancer, 14: 949, 2014.

㻌 4) Kee J. Y., Inujima A., Andoh T., Tanaka K., Li F., Kuraishi Y., Sakurai H., Shibahara N., Saiki I., Koizumi K.: Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation. J Nat Med., doi: 10.1007/s11418-014-0880-6, 2014..

㻌 5) ⋤Ꮚ๛㸪୪ᮌ㝯㞝㸪୕㇂࿴⏨㸪᳜⏣ᆂ࿃㸪୰ཱྀಇဢ㸪㈅἟ⱱ୕㑻㸪ᰘཎ┤฼㸪୕₾ᛅ㐨㸪 ᑠ⏣ཱྀᾈ㸪Ώ㎶㈼἞㸪⸨஭Ὀᚿ㸪႐ከᩄ᫂㸪ᑠᬽᩄ᫂㸪ᑠᕝᜨᏊ㸪⏣ཎⱥ୍㸪ⴗཎᆂ♸㸪

▮ஂಖಟႹ㸪༡⃝₩㸪ᮧᯇៅ୍㸪࿴㎷┤㸪ⰼ㍯ኖᙪ㸸ከ᪋タ࡛ࡢ⤫୍ࡋࡓ⯉デ⮫ᗋデ᩿

グ㍕ࡢసᡂࢆ┠ⓗ࡜ࡋࡓ᪥ᮏࡢ⯉デᩥ⊩ㄪᰝ㸬᪥ᮾ་ㄅ㸪65: 224-230, 2014.

㻌 ۍ ۍ⥲⥲ㄝ㻌

㻌 ¹⁾ ᮲⨾ᬛᏊ㸪ᰘཎ┤฼㸸࠙₎᪉⸆⌮Ꮫ:₎᪉⸆㐺⏝࡟࠾ࡅࡿ฼┈ᛶࠚ5/6⭈᦬ࣛࢵࢺ࡟࠾ࡅࡿ

ᒀ⃰⦰ຊ࡜࢔ࢡ࢔࣏ࣜࣥⓎ⌧࡟ᑐࡍࡿ஬ⱎᩓࡢᙳ㡪㸬᪥⸆⌮ㄅ.㸪143: 65-68, 2014.

ۍ

ۍ⑕⑕౛ሗ࿌

㻌 ¹⁾ ᘬ⥙ᏹᙲ㸪㔝ୖ㐩ஓ㸪⸨ᮏㄔ㸪ᰘཎ┤฼㸪ᔱ⏣㇏㸸⫵⅖ࢆ⧞ࡾ㏉ࡍ㯤Ⰽ∎⑕ೃ⩌ࡢ₎᪉

἞⒪⤒㦂㸬₎᪉ࡢ⮫ᗋ㸪61: 443-448, 2014.

㻌 ²⁾ 㔝ୖ㐩ஓ㸪ᰘཎ┤฼㸪⸨ᮏㄔ㸪Ώࡾⱥಇ㸪ᾏ⪁⃝ⱱ㸪୕⃝ᗈ㈗㸪໭ཎⱥᖾ㸪Ⲩ஭⣪⏤᲍㸪 ᘬ⥙ᏹᙲ㸪ᔱ⏣㇏㸸ᛴᛶ࿧྾ಁ㏕⑕ೃ⩌࡜ࢩࣙࢵࢡࢆకࡗࡓMRSA⭠⅖␲デ౛࡟ᑐࡍࡿ

₎᪉἞⒪⤒㦂㸬᪥ᮾ་ㄅ㸪65: 94-99, 2014.

㻌 ³⁾ ᘬ⥙ᏹᙲ㸪୕⃝ᗈ㈗㸪໭ཎⱥᖾ㸪ᾏ⪁⃝ⱱ㸪Ώࡾⱥಇ㸪㔝ୖ㐩ஓ㸪⸨ᮏㄔ㸪ᰘཎ┤฼㸪 ᔱ⏣㇏㸸⥳⮋⳦㸪࢔ࢫ࣌ࣝࢠࣝࢫឤᰁࢆక࠺㛵⠇࣐ࣜ࢘ࢳ࡟₎᪉἞⒪ࡀ᭷ຠ࡛࠶ࡗࡓ1

౛㸬₎᪉ࡢ⮫ᗋ㸪61: 1099-1104, 2014.

㻌 ⁴⁾ ໭ཎⱥᖾ㸪㔝ୖ㐩ஓ㸪୕⃝ᗈ㈗㸪Ⲩ஭⣪⏤᲍㸪ᾏ⪁⃝ⱱ㸪Ώࡾⱥಇ㸪⸨ᮏㄔ㸪⸨Ọὒ㸪 ᘬ⥙ᏹᙲ㸪㧗ᶫᏹ୕㸪ᰘཎ┤฼㸪ᔱ⏣㇏㸸⮬ᕫච␿ᛶ⮅⅖࡟ࡼࡿ㛢ሰᛶ㯤⑇࡟ⲓⶲⵯ‮

ࢆ౑⏝ࡋࡓ2⑕౛㸬᪥ᮾ་ㄅ㸪65: 202-209, 2014.

ۍ

ۍᏛ఍ሗ࿌

㸦㸦≉≉ูㅮ₇㸪㸪ࢩࢩ࣏ࣥࢪ࣒࢘㸪㸪࣮࣡࣡ࢡࢩࣙࢵࣉ➼㸧

1) Shibahara N., Jo M., Kimura M., Kaneko M., Jono K., Nogami T., Fujimoto M., Hikiami H., Shimada Y.: Effects of different ratios of Paeoniae radix in keishito on small intestinal transit rate and marker compounds. 17th International Congress of Oriental Medicine, 2014, 11, 1-3, Taipei.

2) Kimura M., Hikiami H., Yoshida T., Ma Y., Jo M., Shimada Y., Shibahara N.: Effect of changed amount of Astragali Radix in kigikenchuto on acute wound rat model. 17th International Congress of Oriental Medicine, 2014, 11, 1-3, Taipei.

3) Jo M., Fujimoto T., Kimura M., Shibahara N.: Effect of goreisan on Urinary Concentrating Ability and Expression of Aquaporin 2 in 5/6 Nephrectomized Rats. 17th International Congress of Oriental Medicine, 2014, 11, 1-3, Taipei.

4) ῿⨾ࡉࡸ࠿㸪∾㔝฼᫂㸪ఀ⸨⨾༓✑㸪⬟ໃ඘ᙪ㸪㒯⨾࿴㸪୕ୖṇ฼㸪ᰘཎ┤฼㸪ⰼ㍯ኖ ᙪ㸪୍⯡₎᪉〇๣ጤဨ఍㸪⿙ሯ㧗ᚿ㸪ྜ⏣ᖾᗈ㸸୍⯡⏝₎᪉〇๣ࡢᏳ඲ᛶ☜ಖ࡟㛵ࡍࡿ

◊✲㸦3㸧㸸ࠕᏳ඲࡟౑࠺ࡓࡵࡢ₎᪉ฎ᪉ࡢ☜ㄆ⚊ࠖࡢᐇ⏝໬࡟ྥࡅࡓ࢔ࣥࢣ࣮ࢺㄪᰝ㸬᪥

ᮏ⸆Ꮫ఍➨134ᖺ఍㸪2014, 5, 27-30㸪⇃ᮏ㸬

5) ᰘཎ┤฼㸸ࣉࣛࢭࣥࢱࡢఏ⤫་Ꮫⓗຠ⬟㸬ࢩ࣏ࣥࢪ࣒࢘㸸ࣉࣛࢭࣥࢱ㸦⫾┙࠾ࡼࡧ⫾┙

࿘ᅖ⤌⧊㸧ࡣ࢔ࣥࢳ࢚࢖ࢪࣥࢢ࡟ࡶ෌⏕་⒪࡟ࡶ᭷ຠ㸬➨14ᅇ᪥ᮏᢠຍ㱋Ꮫ఍⥲఍㸪2014, 6, 7-8㸪኱㜰㸬

6) ᰘཎ┤฼㸸ᣦᑟ་ㅮ⩦఍㸬➨65ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬 7) ᰘཎ┤฼㸸ㄽᩥࢆᢞ✏ࡋࡼ࠺2014 Traditional & Kampo Medicine (TKM)ࡢⓎห࡟ࡘ࠸࡚㸬

➨65ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

8) ୕⃝ᗈ㈗㸪㔝ୖ㐩ஓ㸪⸨ᮏㄔ㸪ᘬ⥙ᏹᙲ㸪໭ཎⱥᖾ㸪Ⲩ஭⣪⏤᲍㸪Ώࡾⱥಇ㸪ᾏ⪁⃝ⱱ㸪 ᰘཎ┤฼㸪ᔱ⏣㇏㸸ᐩᒣ኱Ꮫ㝃ᒓ⑓㝔࿴₎デ⒪⛉࡟࠾ࡅࡿ₎᪉⸆࡟ࡼࡿ⸆๣ᛶ㛫㉁ᛶ⫵

⅖㜵Ṇࡢྲྀࡾ⤌ࡳ㸬➨65ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

9) ᰘཎ┤฼㸪᮲⨾ᬛᏊ㸪㔝ୖ㐩ஓ㸪⸨ᮏㄔ㸪ᘬ⥙ᏹᙲ㸪ᔱ⏣㇏㸸᱇ᯞⲍⱎ୸࣭ຍ࿡㏯㐭ᩓ࣭

ᙜᖐⰟ⸆ᩓ᭷ຠ౛࡟࠾ࡅࡿ⯉デᡤぢࡢ᳨ウ㸬➨65ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

10) 㔝ୖ㐩ஓ㸪໭ཎⱥᖾ㸪୕⃝ᗈ㈗㸪Ⲩ஭⣪⏤᲍㸪Ώࡾⱥಇ㸪ᾏ⪁⃝ⱱ㸪⸨ᮏㄔ㸪ᘬ⥙ᏹᙲ㸪 ᰘཎ┤฼㸪ᔱ⏣㇏㸸ᐩᒣ኱Ꮫ㝃ᒓ⑓㝔࿴₎デ⒪⛉࡟࠾ࡅࡿ₎᪉⸆࡟ࡼࡿ⸆๣ᛶ㛫㉁ᛶ⫵

⅖ࡢ᳨ウ㸬➨65ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

11) ⸨ᮏㄔ㸪㔝ୖ㐩ஓ㸪Ώࡾⱥಇ㸪ᾏ⪁⃝ⱱ㸪໭ཎⱥᖾ㸪୕⃝ᗈ㈗㸪ᘬ⥙ᏹᙲ㸪ᰘཎ┤฼㸪 ᔱ⏣㇏㸸⭡㒊⑕≧ࢆ┠ᶆ࡟㏣ຍࡋࡓ᪉๣ࡀ᭷ຠ࡛࠶ࡗࡓဗႃ㢌␗ᖖឤ⑕ࡢ஧⑕౛㸬➨65 ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

12) ໭ཎⱥᖾ㸪ᘬ⥙ᏹᙲ㸪Ⲩ஭⣪⏤᲍㸪୕⃝ᗈ㈗㸪ᾏ⪁⃝ⱱ㸪Ώࡾⱥಇ㸪㔝ୖ㐩ஓ㸪⸨ᮏㄔ㸪 ᰘཎ┤฼㸪ᔱ⏣㇏㸸⏑ⲡ㝃Ꮚ‮ࡀዌຠࡋࡓ཯ᑕᛶ஺ឤ⚄⤒ᛶࢪࢫࢺࣟࣇ࢕࣮ࡢ1౛㸬➨65 ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

13) ῿⨾ࡉࡸ࠿㸪∾㔝฼᫂㸪ఀ⸨⨾༓✑㸪⬟ໃ඘ᙪ㸪㒯⨾࿴㸪୕ୖṇ฼㸪ᰘཎ┤฼㸪ⰼ㍯ኖ ᙪ㸪⿙ሯ㧗ᚿ㸪ྜ⏣ᖾᗈ㸪୍⯡⏝₎᪉〇๣ጤဨ఍㸸୍⯡⏝₎᪉〇๣ࡢᏳ඲ᛶ☜ಖ࡟㛵ࡍ

ࡿ◊✲ࠕᏳ඲࡟౑࠺ࡓࡵࡢ₎᪉ฎ᪉ࡢ☜ㄆ⚊ࠖࡢᐇ⏝໬࡟ྥࡅࡓ࢔ࣥࢣ࣮ࢺㄪᰝ㸬➨65 ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

14) ᰘཎ┤฼㸪㧗ᮌඃ㸪ட஭㈗ᚿ㸪῿⨾༟ஓ㸪ஂᚿ⏣㑳㸪᮲⨾ᬛᏊ㸸㯤㐃ྵ᭷᪉๣ࡀDPP-IV 㜼ᐖάᛶ࡟୚࠼ࡿᙳ㡪࡟㛵ࡍࡿ◊✲㸬➨31ᅇ࿴₎་⸆Ꮫ఍኱఍㸪2014, 8, 30-31㸪༓ⴥ.

15) ᮌᮧ┿᲍㸪୕ᓥ᛭㸪᮲⨾ᬛᏊ㸪㔝ୖ㐩ஓ㸪⸨ᮏㄔ㸪ᘬ⥙ᏹᙲ㸪ᔱ⏣㇏㸪ᰘཎ┤฼㸸⢾ᒀ

⑓ࣔࢹࣝ࡟࠾ࡅࡿάᛶᆺ⾑ᑠᯈ࣭⾑ᑠᯈ࣐࢖ࢡࣟࣃ࣮ࢸ࢕ࢡࣝ࡟ᑐࡍࡿ㥑⑻⾑⸆ࡢຠᯝ㸬

➨31ᅇ࿴₎་⸆Ꮫ఍኱఍㸪2014, 8, 30-31㸪༓ⴥ㸬

16) ᮲⨾ᬛᏊ㸪῿⨾༟ஓ㸪ஂᚿ⏣㑳㸪ධ▮⨾Ἃ㸪ᰘཎ┤฼㸸ࣆ࢜ࢢࣜࢱࢰࣥㄏⓎᮎᲈᛶᾋ⭘

࡟ᑐࡍࡿ஬ⱎᩓࡢຠᯝ࡟㛵ࡍࡿᇶ♏ⓗ᳨ウ㸦➨4ሗ㸧㸬➨31ᅇ࿴₎་⸆Ꮫ఍኱఍㸪2014, 8, 30-31㸪༓ⴥ㸬

17) ῿⨾༟ஓ㸪㧗ᮌඃ㸪᮲⨾ᬛᏊ㸪ᰘཎ┤฼㸸㉺፩ຍᮑ‮ࡢ▼⭯ຍῶ࡟ࡼࡿ↦ᾮ୰࢝ࣝࢩ࢘

࣒㔞ኚ໬ࡢ᳨ウ㸬➨31ᅇ࿴₎་⸆Ꮫ఍኱఍㸪2014, 8, 30-31㸪༓ⴥ㸬

18) ஂᚿ⏣㑳㸪῿⨾༟ஓ㸪ஂᚿ⏣㑳㸪᮲⨾ᬛᏊ㸪ᰘཎ┤฼㸸₎᪉᪉๣↦ࡌᾮ୰ࡢ࣒࢝ࣜ࢘㔞 ࡢ ᐃ㸬➨31ᅇ࿴₎་⸆Ꮫ఍኱఍㸪2014, 8, 30-31㸪༓ⴥ㸬

19) 㛵᰿㯞⌮Ꮚ㸪ⱝᮡᏳᕼ஀㸪ᑠ⏣ཱྀᾈ㸪ᮧᯇៅ୍㸪୪ᮌ㝯㞝㸪᪂஭ಙ㸪ᔱ⏣㇏㸪ᰘཎ┤฼㸪

୕₾ᛅ㐨㸪ⰼ㍯ኖᙪ㸸COI-T㛵㐃ࠕ₎᪉デ⒪ᶆ‽໬ࣉࣟࢪ࢙ࢡࢺࠖ⮬௚ぬᡤぢ⏝⣬ࡢᶆ‽

໬࡟ྥࡅ࡚㸬➨31ᅇ࿴₎་⸆Ꮫ఍኱఍㸪2014, 8, 30-31㸪༓ⴥ㸬

20) ጲ㔝ᴿᚿ㸪᮲⨾ᬛᏊ㸪ᰘཎ┤฼㸸₎᪉↦ࡌ⸆ࢆࣃࢵࢡໟ⿦࡟ࡋࡓ㝿ࡢ㸪ᡂศᢳฟ㔞࡟୚

࠼ࡿᙳ㡪㸦➨2ሗ㸧㸬➨47ᅇ᪥ᮏ⸆๣ᖌ఍Ꮫ⾡኱఍㸪2014, 10, 12-13㸪ᒣᙧ㸬

21) ஬༑ᔒ႐Ꮚ㸪ᡞ㎶୍அ㸪ᑠἨ᱇୍㸸⬡⫫⤌⧊ࡢᙧᡂ࡟ᑐࡍࡿࢣࣔ࢝࢖ࣥCXCL16ࡢ㛵୚㸬

➨35ᅇ᪥ᮏ⫧‶Ꮫ఍㸪2014, 10, 24-25㸪ᐑᓮ㸬

22) ᮌᮧ┿᲍㸪୕ᓥ᛭㸪ᰘཎ┤฼㸪ὠ⏣ᫀᶞ㸸ᤸ㋲ከờ⑕࡟ᑐࡋ࡚஧㛫㸪ປᐑ㸪㛫౑✰ࡀ᭷

ຠ࡛࠶ࡗࡓ1⑕౛㸬➨42ᅇ᪥ᮏఏ⤫㙀⅍Ꮫ఍㸪2014, 10, 25-26㸪㤶ᕝ㸬

23) ᘬ⥙ᏹᙲ㸪㔝ୖ㐩ஓ㸪⸨ᮏㄔ㸪୕⃝ᗈ㈗㸪໭ཎⱥᖾ㸪ᾏ⪁⃝ⱱ㸪Ώࡾⱥಇ㸪ᰘཎ┤฼㸪 ᔱ⏣㇏㸸࢔ࢫ࣮࣌ࣝ࢞⑕ೃ⩌ࡢ࢖ࣛ࢖ࣛឤ࡟㯤㐃‮ࡀዌຠࡋࡓ୍౛㸬➨40ᅇ᪥ᮏᮾὒ་

Ꮫ఍໭㝣ᨭ㒊౛఍㸪2014, 10, 19㸪㔠ἑ㸬

24) 㔝ୖ㐩ஓ㸪ᘬ⥙ᏹᙲ㸪⸨ᮏㄔ㸪ᰘཎ┤฼㸪ᔱ⏣㇏㸸ຍ࿡ᖐ⭁‮࢚࢟ࢫࡀዌຠࡋࡓ㧗㱋⪅

ࡢ㡢ኌࢳࢵࢡ(㐜ⓎᛶTourette⑕ೃ⩌)ࡢ୍౛㸬➨40ᅇ᪥ᮏᮾὒ་Ꮫ఍໭㝣ᨭ㒊౛఍㸪2014, 10, 19㸪㔠ἑ㸬

ۍ

ۍࡑࡑࡢ௚ 㻌㻌

1) ᰘཎ┤฼㸸࿧྾ჾ⑌ᝈ࡜₎᪉⸆㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨9ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪 2014, 6, 18㸪ᐩᒣ㸬

2) ᰘཎ┤฼㸸⑕౛᳨ウ㸬➨49ᅇᐩᒣ₎᪉ㄯヰ఍㸪2014, 1, 21㸪ᐩᒣ㸬

3) ᰘཎ┤฼㸸デ⒪ࡢᖜࡀᣑࡀࡿ₎᪉ᴫㄽ 㹼Ẽ⾑Ỉ㹼㸬➨2ᅇࡸࡉࡋ࠸࿴₎デ⒪Ꮫㅮᗙ㸪2014, 1, 25㸪኱ὠ㸬

4) ᰘཎ┤฼㸸ពእ࡜㠃ⓑ࠸㸟 ₎᪉἞⒪ࡢ⪃࠼᪉㸪⚾ࡢ࠾່ࡵฎ᪉࣋ࢫࢺ10㸪⑌ᝈู࢔ࣉࣟ

࣮ࢳ 㢼㑧࣭࢖ࣥࣇ࢚ࣝࣥࢨ㸪⑌ᝈู࢔ࣉ࣮ࣟࢳ ෭࠼࡜③ࡳ㸬ࡍࡄ࡟ᙺ❧ࡘ㸟 ₎᪉ࢭ࣑

ࢼ࣮ධ㛛⦅㸪2014, 1, 26㸪ி㒔㸬

5) ᰘཎ┤฼㸸⬻࣭⬨㧊⑌ᝈ࡜₎᪉⸆㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨10ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪 2014, 2, 15㸪ᐩᒣ㸬

6) ᰘཎ┤฼㸸ⴱ᰿‮࣭㯏㛛෤‮࣭኱ᘓ୰‮࣭Ⱏ⸆⏑ⲡ‮࣭ᢚ⫢ᩓ࣭ຍ࿡㏯㐭ᩓࡢ㛵㐃ฎ᪉

࡟ࡘ࠸࡚㸪∵㌴⭈Ẽ୸࣭㜵㢼㏻⪷ᩓ࣭භྩᏊ‮࣭⿵୰┈Ẽ‮࣭༑඲኱⿵‮ࡢ㛵㐃ฎ᪉࡟

ࡘ࠸࡚㸬Second Step ₎᪉ 㸫ᅔࡗࡓ᫬ࡢḟࡢ୍ᡭ㸫㸪2014, 2, 16㸪ி㒔㸬 7) ᰘཎ┤฼㸪᮲⨾ᬛᏊ㸸⑕౛᳨ウ㸬➨16ᅇ₎᪉デ᩿◊✲఍㸪2014, 2, 20㸪ᐩᒣ㸬

8) ᰘཎ┤฼㸸┳ㆤ࡟ά࠿ࡏࡿ₎᪉་Ꮫࡢ⪃࠼᪉ձ㸬➨3ᅇ┳ㆤᏛ⣔₎᪉ᩍ⫱◊✲఍㸪2014, 2, 21㸪ி㒔㸬

9) ᰘཎ┤฼㸸₎᪉⸆ࡢ౑࠸᪉ ⑕౛ᥦ♧࠿ࡽ⪃࠼ࡿFirst choice࡜㚷ูฎ᪉㸬➨3ᅇࡸࡉࡋ࠸࿴

₎デ⒪Ꮫㅮᗙ㸪2014, 3, 8㸪኱ὠ㸬

10) ᰘཎ┤฼㸸⑕౛᳨ウ㸬➨50ᅇᐩᒣ₎᪉ㄯヰ఍㸪2014, 3, 18㸪ᐩᒣ㸬

11) ᰘཎ┤฼㸸㝜㝧⹫ᐇ࣭භ⑓఩㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨1ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪2014, 4, 12㸪ᐩᒣ㸬

12) ᰘཎ┤฼㸪᮲⨾ᬛᏊ㸸⑕౛᳨ウ㸬➨17ᅇ₎᪉デ᩿◊✲఍㸪2014, 4, 17㸪ᐩᒣ㸬

13) ᰘཎ┤฼㸸Ẽ⾑Ỉ࡜஬⮚㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨2ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪2014, 5, 10㸪 ᐩᒣ㸬

14) ᰘཎ┤฼㸸ᅄデ࡟ࡘ࠸࡚㸬ᐩᒣ኱Ꮫ㉬㠴఍㸪2014, 5, 14㸪ᐩᒣ㸬

15) ᰘཎ┤฼㸸Ẽ⾑Ỉデ᩿㸬ᖹᡂ26ᖺᗘᐩᒣᕷẸ኱Ꮫ ⏕ά་Ꮫ⸆ᏛࢆᏛࡪ㸪2014, 5, 16㸪ᐩ ᒣ㸬

16) ᰘཎ┤฼㸸⑕౛᳨ウ㸬➨51ᅇᐩᒣ₎᪉ㄯヰ఍㸪2014, 5, 20㸪ᐩᒣ.

17) ᰘཎ┤฼㸸⏕ά⩦័⑓࡜₎᪉㸬ᖹᡂ26ᖺᗘᐩᒣᕷẸ኱Ꮫ ⏕ά་Ꮫ⸆ᏛࢆᏛࡪ㸪2014, 6, 13㸪 ᐩᒣ㸬

18) ᰘཎ┤฼㸪᮲⨾ᬛᏊ㸸⑕౛᳨ウ㸬➨18ᅇ₎᪉デ᩿◊✲఍㸪2014, 6, 19㸪ᐩᒣ㸬

19) ᰘཎ┤฼㸸₎᪉་Ꮫࡢデᐹ᪉ἲ࡜₎᪉⸆ࡢᡂࡾ❧ࡕ㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨3ᅇ₎

᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪2014, 6, 21㸪ᐩᒣ㸬

20) ᮌᮧ┿᲍㸸㙀⅍἞⒪ࡢᐇ㝿㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨3ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪2014, 6,

21㸪ᐩᒣ㸬

21) ᰘཎ┤฼㸪᪥ᮏᮾὒ་Ꮫ఍⦅㞟ጤဨ఍㸸ㄽᩥࢆ᭩ࡇ࠺2014 Traditional & Kampo Medicine (TKM)ࡢⓎห࡟ࡘ࠸࡚㸬➨65ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

22) ᰘཎ┤฼㸪᪥ᮏᮾὒ་Ꮫ఍ᑓ㛛་ไᗘጤဨ఍㸸ᣦᑟ་ㅮ⩦఍ 㸫₎᪉ᑓ㛛་ࡢࡇࢀ࠿ࡽ㸫㸬

➨65ᅇ᪥ᮏᮾὒ་Ꮫ఍Ꮫ⾡⥲఍㸪2014, 6, 27-29㸪ᮾி㸬

23) ᰘཎ┤฼㸸₎᪉་Ꮫࡢ⮫ᗋデ᩿㸬ᐩᒣ┴೺ᗣࢭ࣑ࢼ࣮&➨4ᅇᐩᒣࡢࡃࡍࡋᕷẸㅮᗙኟᮇ ࢭ࣑ࢼ࣮㸪2014, 7, 5㸪ᐩᒣ㸬

24) ᰘཎ┤฼㸸₎᪉ᴫㄽ㸦ฎ᪉㑅ᢥࡢᇶᮏ㸧㸪೏ᛰឤ࣭ኟࡤ࡚࡟㛵ࡍࡿ₎᪉ฎ᪉ࡢ㑅ᢥ⾡㸪෭

࠼⑕࡟㛵ࡍࡿ₎᪉ฎ᪉ࡢ㑅ᢥ⾡㸬ᐩᒣ₎᪉་Ꮫධ㛛ࢭ࣑ࢼ࣮㸪2014, 7, 12㸪ᐩᒣ㸬

25) ᰘཎ┤฼㸸⑕౛᳨ウ㸬➨52ᅇᐩᒣ₎᪉ㄯヰ఍㸪2014, 7, 15㸪ᐩᒣ㸬

26) ᰘཎ┤฼㸸⪥㰯ဗႃ⛉⑌ᝈ࡜₎᪉⸆㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨4ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮ ᗙ㸪2014, 7, 26㸪ᐩᒣ㸬

27) ᰘཎ┤฼㸸೺ᗣ࡜₎᪉་Ꮫ㸬ᖹᡂ26ᖺᗘ⊩⾑㐠ື᥎㐍ᐩᒣ┴኱఍㸪2014, 7, 27㸪ᐩᒣ㸬 28) ᰘཎ┤฼㸸⸆㒔ᐩᒣࡢṔྐ࡜₎᪉㸬໬ᏛᕤᏛ఍࣐࢖ࢡࣟ໬Ꮫࣉࣟࢭࢫศ⛉఍㸪2014, 8, 2㸪

ᐩᒣ㸬

29) ᰘཎ┤฼㸸₎᪉་Ꮫࡢᇶᮏⓗᴫᛕ㸬➨19ᅇᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤኟᮇࢭ࣑ࢼ࣮㸪 2014, 8, 20-22㸪ᐩᒣ㸬

30) ᰘཎ┤฼㸪Ώࡾⱥಇ㸪᮲⨾ᬛᏊ㸸Ẽ⾑Ỉデ᩿ἲ㸬➨19ᅇᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ ኟᮇࢭ࣑ࢼ࣮㸪2014, 8, 20-22㸪ᐩᒣ㸬

31) ᰘཎ┤฼㸪᮲⨾ᬛᏊ㸸⑕౛᳨ウ㸬➨19ᅇ₎᪉デ᩿◊✲఍㸪2014, 8, 21㸪ᐩᒣ㸬

32) ᰘཎ┤฼㸸┳ㆤ࡟ά࠿ࡏࡿ₎᪉་Ꮫࡢデᐹἲ㸬➨4ᅇ┳ㆤᏛ⣔₎᪉ᩍ⫱◊✲఍㸪2014, 8, 22㸪

ி㒔㸬

33) ᰘཎ┤฼㸸₎᪉་Ꮫᴫㄽ࡜㢖⏝᪉๣㸬Ⓩ㘓㈍኎⪅⏕ᾭᏛ⩦◊ಟAㅮᗙ㸪2014, 8, 26㸪ᐩᒣ㸬 34) ᰘཎ┤฼㸸First Step ₎᪉ 㸫ࡇࢀࡔࡅࡣ▱ࡗ࡚࠾ࡁࡓ࠸࠾່ࡵฎ᪉㸫㸬➨2ᅇி⾤㐨₎᪉

◊✲఍Ꮫ⾡ㅮ₇఍㸪2014, 8, 28㸪ᯛ᪉㸬

35) ᰘཎ┤฼㸸⓶⭵⑌ᝈ࡜₎᪉⸆㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨5ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪2014, 9, 6㸪ᐩᒣ㸬

36) ᰘཎ┤฼㸸⑕౛᳨ウ㸬➨53ᅇᐩᒣ₎᪉ㄯヰ఍㸪2014, 9, 9㸪ᐩᒣ㸬

37) Shibahara N.: Recent knowledge on Paeoniae Radix. The 20th Symposium on future trends in drug discovery -Strategies for Drug Development using Natural Products-. 2014, 10, 6, Seoul.

38) ᰘཎ┤฼㸪᮲⨾ᬛᏊ㸸⑕౛᳨ウ㸬➨20ᅇ₎᪉デ᩿◊✲఍㸪2014, 10, 16㸪ᐩᒣ㸬

39) ᰘཎ┤฼㸸⏕ά⩦័⑓࡜₎᪉⸆㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨6ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪 2014, 10, 18㸪ᐩᒣ㸬

40) ᰘཎ┤฼㸸᭦ᖺᮇ㞀ᐖࡢ₎᪉἞⒪㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨7ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪 2014, 11, 15㸪ᐩᒣ㸬

41) ᰘཎ┤฼㸸⑕౛᳨ウ㸬➨54ᅇᐩᒣ₎᪉ㄯヰ఍㸪2014, 11, 18㸪ᐩᒣ㸬

42) ໭ཎⱥᖾ㸪ᘬ⥙ᏹᙲ㸪㔝ୖ㐩ஓ㸪⸨ᮏㄔ㸪୕⃝ᗈ㈗㸪ᾏ⪁⃝ⱱ㸪Ώࡾⱥಇ㸪ᰘཎ┤฼㸪 ᔱ⏣㇏㸸࢔ࢫ࣮࣌ࣝ࢞⑕ೃ⩌ࡢ࢖ࣛ࢖ࣛឤ࡟㯤㐃‮ࡀዌຠࡋࡓ୍౛㸬➨18ᅇ࿴₎デ⒪Ꮫ ࢩ࣏ࣥࢪ࣒࢘㸪2014, 11, 29㸪ᐩᒣ㸬

43) 㔝ୖ㐩ஓ㸪ᘬ⥙ᏹᙲ㸪⸨ᮏㄔ㸪ᰘཎ┤฼㸪ᔱ⏣㇏㸸ຍ࿡ᖐ⭁‮࢚࢟ࢫࡀዌຠࡋࡓ㧗㱋⪅

ࡢ㡢ኌࢳࢵࢡ(㐜ⓎᛶTourette⑕ೃ⩌)ࡢ୍౛㸬➨18ᅇ࿴₎デ⒪Ꮫࢩ࣏ࣥࢪ࣒࢘㸪2014, 11, 29㸪ᐩᒣ㸬

44) ᰘཎ┤฼㸸ࡇࢀࡔࡅࡣ▱ࡗ࡚࠾ࡁࡓ࠸₎᪉ฎ᪉㸪㢼㑧࣭࢔ࣞࣝࢠ࣮࡟₎᪉ࢆ౑ࡗ࡚ࡳࡼ

࠺㸪෭࠼࣭୙ᐃឋッ࡟₎᪉ࢆ౑ࡗ࡚ࡳࡼ࠺㸬₎᪉ධ㛛ࢭ࣑ࢼ࣮in ࡉ࠸ࡓࡲ㸪2014, 11, 30㸪

኱ᐑ㸬

45) ᰘཎ┤฼㸸࿧྾ჾ⑌ᝈࡢ₎᪉἞⒪㸬ᐩᒣࡢࡃࡍࡋ ᖹᡂ26ᖺᗘ➨8ᅇ₎᪉་Ꮫ࡜⏕⸆ㅮᗙ㸪 2014, 12, 6㸪ᐩᒣ㸬

46) ᰘཎ┤฼㸸ᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ࡟ࡘ࠸࡚㸬WAKANKEN/NEKKEN JOINT

SEMINARᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ࣭㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᡤ➨4ᅇ஺ὶࢭ࣑ࢼ࣮㸬

2014, 12, 8㸪ᐩᒣ㸬

47) Shibahara N.: Institute of Natural Medicine, University of Toyama. The 2nd Joint Symposium between NPRI, Seoul National University and INM, University of Toyama, 2014, 12, 10, Seoul.

48) Koizumi K.: Novel Evaluation system by using TR-LE cells for lymphangiogenesis in vitro. The 2nd Joint Symposium between NPRI, Seoul National University and INM, University of Toyama, 2014, 12, 10, Seoul.

49) ᰘཎ┤฼㸸㢼㑧࣭෭࠼⑕ࡢ₎᪉἞⒪㸬Ⓩ㘓㈍኎⪅⏕ᾭᏛ⩦◊ಟAㅮᗙ㸪2014, 12, 16㸪ᐩ ᒣ㸬

50) ᰘཎ┤฼㸪᮲⨾ᬛᏊ㸸⑕౛᳨ウ㸬➨21ᅇ₎᪉デ᩿◊✲఍㸪2014, 12, 18㸪ᐩᒣ㸬

ۍ

ۍඹඹྠ◊✲

Ꮫෆ

1) ᔱ⏣㇏㸦ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫ◊✲㒊㸦་Ꮫ㸧࿴₎デ⒪Ꮫㅮᗙᩍᤵ㸧㸪ࠕ₎᪉་Ꮫࡢ⮫ᗋ◊ಟ

ࣉࣟࢢ࣒ࣛࡢ㛤Ⓨࠖ㸪1999, 4㹼

2) ᔱ⏣㇏㸦ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫ◊✲㒊㸦་Ꮫ㸧࿴₎デ⒪Ꮫㅮᗙᩍᤵ㸧㸪⸨ᮏㄔ㸦ᐩᒣ኱Ꮫ་Ꮫ

⸆Ꮫ◊✲㒊㸦་Ꮫ㸧࿴₎デ⒪Ꮫㅮᗙㅮᖌ㸧㸪ᖖᒣᖾ୍㸦ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫ◊✲㒊㸦་Ꮫ㸧

⑓⌮デ᩿Ꮫ෸ᩍᤵ㸧㸪ࠕ⫢࣭⭈⥺⥔໬࡟ᑐࡍࡿ᱇ᯞⲍⱎ୸ࡢ᭷ຠᛶ࡟㛵ࡍࡿ⸆⌮Ꮫⓗ◊✲ࠖ㸪 2009, 2㹼

3) ᘬ⥙ᏹᙲ㸦ᐩᒣ኱Ꮫ㝃ᒓ⑓㝔࿴₎デ⒪⛉ㅮᖌ㸧㸪ྜྷ⏣ῄᏊ㸦ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫ◊✲㒊㸦་

Ꮫ㸧෌⏕་Ꮫㅮᗙ෸ᩍᤵ㸧㸪ࠕ〟⒔࡟ᑐࡍࡿ᪂つ἞⒪⸆๣ࡢ㛤Ⓨࠖ㸪2009, 4㹼

4) ᑠᯇ࠿ࡘᏊ㸦ᐩᒣ኱Ꮫ࿴₎་⸆Ꮫ⥲ྜ◊✲ᡤ⏕⸆㈨※⛉Ꮫศ㔝ᩍᤵ㸧㸪ᮒጨ㸦ᐩᒣ኱Ꮫ࿴

₎་⸆Ꮫ⥲ྜ◊✲ᡤ⏕⸆㈨※⛉Ꮫศ㔝ຓᩍ㸧㸪ࠕᐩᒣ┴ࣈࣛࣥࢻⰟ⸆ࠖࡢᇶ┙࣭⮫ᗋ◊✲㸪 2014, 4, 1㹼

5) 㧗ᮏ⪃୍㸦ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫ◊✲㒊⚄⤒࣭ᩚ᚟Ꮫㅮᗙຓᩍ㸧㸪ࠕᛴᛶ࣭ளᛴᛶᮇ㢁㒊③࣭

⭜③࡟ᑐࡍࡿ≀⌮࣭⌮Ꮫ⒪ἲࡢ☜❧࡟㛵ࡍࡿ⮫ᗋⓗ◊✲(ᛴᛶ࣭ளᛴᛶᮇ㢁㒊࣭⭜㒊③࡟

ᑐࡍࡿࢺ࣮࣏ࣜ࢞࢖ࣥࢺᅽ㏕἞⒪ἲࡢຠᯝ㸸ࣛࣥࢲ࣒໬ẚ㍑ヨ㦂)ࠖ㸪2009, 11, 9㹼 6) 㧗ᮏ⪃୍㸦ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫ◊✲㒊⚄⤒࣭ᩚ᚟Ꮫㅮᗙຓᩍ㸧㸪ࠕᛴᛶ࣭ளᛴᛶᮇ㢁㒊࣭⭜

③࡟ᑐࡍࡿ≀⌮࣭⌮Ꮫ⒪ἲࡢ☜❧࡟㛵ࡍࡿ⮫ᗋⓗ◊✲(ᛴᛶ࣭ளᛴᛶᮇ㢁㒊࣭⭜㒊③࡟ᑐ ࡍࡿ ⇕⒪ἲཬࡧᐮ෭⒪ἲ࡜ࢺ࣮࣏ࣜ࢞࢖ࣥࢺᚐᡭᅽ㏕⒪ἲ࡜ࡢే⏝἞⒪ຠᯝࡢ᳨ウ㸸

ࣛࣥࢲ࣒໬ẚ㍑ヨ㦂)㸪2013, 4, 1㹼 ᅜෆ

1) ⰼ㍯ኖᙪ㸦໭㔛኱Ꮫᮾὒ་Ꮫ⥲ྜ◊✲ᡤᡤ㛗㸧㸪ᑠ⏣ཱྀᾈ㸦໭㔛኱Ꮫᮾὒ་Ꮫ⥲ྜ◊✲ᡤ

๪ᡤ㛗㸧㸪୕₾ᛅ㐨㸦ᓥ┴❧་⛉኱Ꮫ఍ὠ་⒪ࢭࣥࢱ࣮₎᪉་Ꮫㅮᗙᩍᤵ㸧㸪୪ᮌ㝯㞝㸦༓

ⴥ኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲㝔࿴₎デ⒪Ꮫㅮᗙ෸ᩍᤵ㸧㸪᪂஭ಙ㸦ᮾᾏ኱Ꮫ་Ꮫ㒊ෆ⛉Ꮫ⣔෸ᩍ

ᤵ㸧㸪ᮧᯇៅ୍㸦⮬἞་⛉኱Ꮫෆ⛉Ꮫㅮᗙ⚄⤒ෆ⛉Ꮫ㒊㛛≉࿨ᩍᤵ㸧㸪ᔱ⏣㇏㸦ᐩᒣ኱Ꮫ

་Ꮫ⸆Ꮫ◊✲㒊࿴₎デ⒪Ꮫㅮᗙᩍᤵ㸧㸪ࠕ₎᪉ᶆ‽໬ࣉࣟࢪ࢙ࢡࢺࠖ㸪2013, 2, 1㹼

2) ྜ⏣ᖾ㸦ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ⸆ရ㒊/⏕⸆㒊㒊㛗㸧㸪⿙ሯ㧗ᚿ㸦ᅜ❧་⸆ရ㣗ရ⾨

⏕◊✲ᡤ⏕⸆㒊㛗㸧㸪ᨻ⏣ࡉࡸ࠿㸦ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ⏕⸆㒊➨஧ᐊ㸧㸪∾㔝฼᫂

㸦ྡྂᒇᕷ❧኱Ꮫ኱Ꮫ㝔⸆Ꮫ◊✲⛉⏕⸆Ꮫศ㔝ᩍᤵ㸧㸪ఀ⸨⨾༓✑㸦ி㒔኱Ꮫ኱Ꮫ㝔⸆Ꮫ

◊✲⛉⸆ရ㈨※Ꮫ෸ᩍᤵ㸧㸪⬟ໃ඘ᙪ㸦ྡᇛ኱Ꮫ⸆Ꮫ◊✲⛉⸆Ꮫᑓᨷᩍᤵ㸧㸪㒯⨾࿴㸦໭

㔛኱Ꮫ⏕࿨⛉Ꮫ◊✲ᡤ࿴₎⸆≀Ꮫ◊✲ᐊ≉௵ຓᩍ㸧㸪୕ୖṇ฼㸦࣑࣑࢝⸆ᒁ㸧㸪ⰼ㍯ኖᙪ 㸦໭㔛኱Ꮫᮾὒ་Ꮫ⥲ྜ◊✲ᡤᡤ㛗㸧㸪ࠕ୍⯡⏝་⸆ရ࡟࠾ࡅࡿ㸪໬Ꮫྜᡂရ➼ࡢࣜࢫࢡ

༊ศࡢぢ┤ࡋ࡜₎᪉〇๣ࡢᏳ඲ᛶ☜ಖ࡟㛵ࡍࡿ◊✲ࠖ㸪2012, 4㹼

2) ୪ᮌ㝯㞝㸦༓ⴥ኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲㝔࿴₎デ⒪Ꮫ෸ᩍᤵ㸧㸪୰ཱྀಇဢ㸦༓ⴥ኱ᏛᕤᏛ㒊་

⒪ᨭ᥼ࢩࢫࢸ࣒෸ᩍᤵ㸧㸪ࠕ㢦Ⰽཬࡧ⯉࡞࡝⢓⭷Ⰽࡢᐃ㔞ⓗ ᐃ㸪ゎᯒࢩࢫࢸ࣒㛤Ⓨࠖ㸪 2012, 4㹼

3) ᖹᒣㅬ஧㸦㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᡤᩍᤵ㸧㸪ࠕ₎᪉་Ꮫⓗ⑓ែㄆ㆑ࠕドࠖࢆᇶ┙࡜ࡋࡓᬑ 㐢ⓗ⤫ྜ་Ꮫ࡬ࡢᒎ㛤ࠖ㸪2012, 10㹼

4) ྜཎ୍ᖾ㸦ᮾி኱Ꮫ⏕⏘ᢏ⾡◊✲ᡤᩍᤵ㸧㸪ࠕᩘ⌮ࣔࢹࣝ࠿ࡽ⣣ゎࡃ₎᪉⸆ࡢ」㞧⣔ືຊ Ꮫ 㹼ࠕᮍ⑓ࠖࡢ᳨ฟ࠿ࡽࡢ᪂ࡓ࡞๰⸆࡟ྥࡅ࡚㹼ࠖ㸪2013, 11㹼

5) ᪥ᮏ〇⸆ᕤᴗᰴᘧ఍♫㸸ࠕ∵㯤Ύᚰඖࡢస⏝ᶵᗎ࡟㛵ࡍࡿ◊✲ࠖ㸪2014, 9㹼

6) ࢡࣛࢩ࢚〇⸆ᰴᘧ఍♫₎᪉◊✲ᡤ㸸ࠕᒀ୰࢝ࢸࢥ࣑ࣛࣥ ᐃ࡟ࡼࡿ₎᪉ฎ᪉᭷⏝ᛶࡢ⸆⌮

ⓗ᳨ウࠖ㸪2014, 12㹼

ۍ

ۍ㠀㠀ᖖ໅ㅮᖌ 㻌

㻌 1) ᰘཎ┤฼㸸ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫᩍ⫱㒊㸦⸆Ꮫ㸧㸪ࠕᮾὒ་Ꮫᴫㄽࠖ㸪2014, 1, 9㹼1, 30㸪2014, 10, 2㹼12, 18.

㻌 2) ᮲⨾ᬛᏊ㸸㧗ᒸᕷ་ᖌ఍┳ㆤᑓ㛛Ꮫᰯ㸪ࠕᚤ⏕≀Ꮫࠖ㸪2014, 4. 14㹼8. 5.

㻌 3) ᮲⨾ᬛᏊ㸸ᐩᒣ་⒪⚟♴ᑓ㛛Ꮫᰯ┳ㆤᏛ⛉㸪ࠕᚤ⏕≀Ꮫࠖ㸪2014, 4, 14㹼9, 19.

㻌 4) ᰘཎ┤฼㸸ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫᩍ⫱㒊㸪ࠕ࿴₎་⸆Ꮫධ㛛ࠖ㸪2013, 4, 18.

㻌 5) ᰘཎ┤฼㸸ᐩᒣ኱Ꮫ་Ꮫ⸆Ꮫᩍ⫱㒊㸦་Ꮫ⣔㸧ಟኈㄢ⛬┳ㆤᏛᑓᨷ㸪ࠕ⑓ែ⏕⌮Ꮫࠖ㸪2014, 7, 28.

㻌 6) ᰘཎ┤฼㸸⚟஭኱Ꮫ㸪ࠕᐇ㊶⮫ᗋ⑓ែᏛࠖ㸪2014, 7, 28.

㻌 7) ᰘཎ┤฼㸸ᐩᒣ⚟♴▷ᮇ኱Ꮫ┳ㆤᏛ⛉㸪ࠕᮾὒ་Ꮫࠖ㸪2013, 9, 11㹼9, 25.

㻌 8) ᮲⨾ᬛᏊ㸸ᐩᒣᕷ❧┳ㆤᑓ㛛Ꮫᰯ㸪ࠕឤᰁච␿Ꮫࠖ㸪2014, 6. 26㹼11. 6.

㻌 9) ᰘཎ┤฼㸸ᐩᒣ኱Ꮫ኱Ꮫ㝔་Ꮫ⸆Ꮫᩍ⫱㒊㸦་Ꮫ⣔㸧ಟኈㄢ⛬㸪ࠕᮾὒ་Ꮫᴫㄽࠖ㸪2013, 12, 3.

㻌 10) ᑠἨ᱇୍㸸ᐩᒣ⑓㝔㝃ᒓ┳ㆤᏛᰯ㸪ࠕᰤ㣴࣭⏕໬Ꮫࠖ㸪2014, 4, 11㹼7, 24.

㻌 㻌 㻌

ۍ

ۍ◊◊✲㈝ྲྀᚓ≧ἣ㻌

㻌 ¹⁾ ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝㸪ᇶ┙◊✲㸦C㸧㸦௦⾲㸸ᰘཎ┤฼㸪⥅⥆㸧ࠕάᛶᆺ⾑ᑠᯈࢆ௓ࡋࡓ

⢾ᒀ⑓⣽ᑠ⾑⟶⑕ࡢ㐍ᒎᢚไຠᯝࢆ᭷ࡍࡿ⏕⸆ࡢ᥈⣴ࠖ110୓

㻌 ²⁾ ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝㸪ⴌⱆ◊✲㸦௦⾲㸸ᑠἨ᱇୍㸪⥅⥆㸧ࠕ⛣᳜ࡍࡿࡔࡅ࡛NASHࢆⓎ

⑕ࡉࡏࡿNKT⣽⬊ࡢⓎぢ㸪ࡑࡢᶵ⬟ゎᯒ࡜๰⸆࡬ࡢᣮᡓࠖ150୓

㻌 ³⁾ ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝㸪ⱝᡭ◊✲㸦B㸧㸦௦⾲㸸᮲⨾ᬛᏊ㸪⥅⥆㸧ࠕ஬ⱎᩓ࡟ࡼࡿ࢔ࢡ࢔࣏

ࣜࣥ2Ⓨ⌧ㄪ⠇ᶵᗎཬࡧᮎᲈᛶᾋ⭘ᨵၿᶵᗎࡢゎ᫂ࠖ90୓

㻌 ⁴⁾ 㔜Ⅼ㓄ศ⤒㈝ᩍ⫱◊㸪ྜཎ୍ᖾ㸦ᮾி኱Ꮫ㸧㸦ศᢸ㸸ᑠἨ᱇୍㸧ࠕᩘ⌮ࣔࢹࣝ࠿ࡽ⣣ゎࡃ

₎᪉⸆ࡢ」㞧⣔ືຊᏛ 㹼ࠕᮍ⑓ࠖࡢ᳨ฟ࠿ࡽࡢ᪂ࡓ࡞๰⸆࡟ྥࡅ࡚㹼ࠖ100୓

㻌 ⁵⁾ ᐩᒣ┴ཷク◊✲ ࿴₎⸆࣭ࣂ࢖࢜ࢸࢡࣀࣟࢪ࣮◊✲㸪ࠕᐩᒣ┴ࣈࣛࣥࢻⰟ⸆ࠖࡢᇶ┙࣭⮫

ᗋ◊✲㸦௦⾲㸸ᰘཎ┤฼㸪᪂つ㸧ࠕᐩᒣ┴⏘Ⱏ⸆ࡢရ㉁ホ౯࡟ಀࡿ⮫ᗋ◊✲ࠖ150୓

㻌 㻌 㻌

ۍ

ۍ◊◊✲ᐊᅾ⡠⪅㻌

1.኱Ꮫ㝔๓ᮇ2ᖺ㸸㣤ሯ⣫ྐ

2.⸆Ꮫ㒊⸆Ꮫ⛉6ᖺ㸸῿⨾༟ஓ 3.⸆Ꮫ㒊⸆Ꮫ⛉5ᖺ㸸ஂᚿ⏣㑳

4.⸆Ꮫ㒊⸆Ꮫ⛉4ᖺ㸸ධ▮⨾Ἃ㸪㡲ᓮ⨾㈗Ꮚ 5.⸆Ꮫ㒊⸆Ꮫ⛉3ᖺ㸸ᡂ⏣⤢㤶㸪Ỉ㔝♸௓

ドキュメント内 和 漢 医 薬 学 総 合 研 究 所 年 報 第 四 一 巻 二 〇 一 四 年 富 山 大 学 (ページ 54-95)