!
"#$%& '()*+,-./01 /2%34 0& '(56#7
%& 89#$:;<=>,?@A
BC;DEFGIgEH&'(#$%IJ, 6;KL#M !0& NO
/E& P/#QRSTBU! VIgEH/WX
#"#$YZ ;%[&E& \]''(+ ;(
^_`)G/ab*;-cd& e+;,-/
E& f;gh.//G ;
ijd- ,O#& k63& '(56;01
G23;lcGm& noNp45l;6- q r#s2t;#7G
1. !"#$%& !' e+089:u '(o34%& ;v5#
w<x=>./NO& e+0?y@*/j
1.1 !"#$%
e+C(z{|;}AB/}CAB V~(/~
(NO ~(Z /#3=& !IgE-ELISA;ij-
/. & 2/3q@ !& D'(/E ,
Nj-~(3;:G./EON/j- ~
(,RSTB;EON#G-#& a-TB
(;F~(HB;Gj-$3H[E& \{
T#$%HBB;IJ_KLE- MN [&Wt& SQQQ(Q)PPF%OE;4woU!34%&
.0'3=~(PQ34./REE- ,O#
?#[&E-Wt& QQQPPU!IgEWXB#"Sge RSTBU!34j- "& ~(,OEMN QQPFP2$PQQPFwIgEWXT;UE./;EO N#E- '(.ORSTBBMN;
%OEUG/a./0&VIgEH;IJ,G
/O& e+'(U!@WX;5#)E-
l34
kY&}AB3NO0IgEWXBprotein ZV ¡Z
>Z(~¢(m;lcE-
1.2 !'&()*+,- s#RSTBU!;[£Ee+\;''(+G
-#& "¤F¥],NOg^¥];¦{(~
E- _§/E& '('¨+T©./0wª «
34& ¥]¬#HBn& No®¯B'
./&°±Wt&Tricoderma viridePQA
®2$Streptomyces griseusPQB® V{²
®Z ;`«c ³& A®a¤#2& (~
¢(;3[E& No1´;ij- µ#& {²®a
¤#2& 4b"¤WB;¶,& No ¡G
. 9 ·#
<¸!¹º#» c¼+½d¸ / 33
!" #$"
%&'() *+ #,-
$+ ./ + 01+2134+
567, 8 %&'+9 :2;
<= >4?6,-4@
+- A+3B
%&' C3 D6EF '+ D" GG3 H
#6I+6 JK!L D#567, 7 4 4LM8+"#- E N&O P&Q O(R DS$% T&2)'
"A(U"-4
1.3
+)V+*W A+8XY+6
!J+,-2,-S.+# !"Z/!0"
8S ,-2)#[$ + #
\!"21(A#1(L(4D#"!8(, +#2] D"!+.$34 [$+B65"#6#67) # /W 5#2]!" D+D7"
7!8^Brown Norway_&G
8 5%&'`( a9(
9)b.*-Vc d
e:+;+2)9f<,-=>g+?@hiEh
?hA#BC 1 D+a9IgG1, IgG2a, IgEj++Ek.F D"!+/l[0 d"TG-mnG op 2]!" HI
,--4A+1JDKqhrL9M- stG PtNO2P(R$Q-4
u3+R.A S4v
wZ8 ST5$
western$QDx protein Z(R#U6VW67
5X4y protein Zz{t|}'
~SMD8! 4z{
Y2]!" A7:4-S$Z
L4[\" +#+ VW+
uM672]!" ]^ 4v+_R R .A:/`+4
2. (BSA)
8ABSA4v # 3a+S+
.|GDb HSA/4v(4 u96BSA HSA+c76-SL :+SdS;
e-4 D+D8! BSAHSA+ud<+CL a(3#A2) f"2] g3
#$hi +*W j=(AIgE*#mnG -EXXV (wEYAV(aa338ῌ341), ESKV (aa468ῌ471), ENFV(aa547ῌ550), :2;LILNR(aa453ῌ457) 0 TG- f"kM+>SX4y
d46 IgE*# HPEYAVSVLL (aa 336ῌ345) :2;VMENFVAF(aa545ῌ542)d"E HSA 6SD67Dl? mE338D:2
;E547D+Vn, +*W m2,-IgE*#
#CLD8! AIgED+E f-4*@" 3]-o4D m
A1JDKqhG-ABcp3-hiD x stGPtNOE'Th1*LD#"!8 (, D" ^N+9`q S +67
C-F'{(PGM)r8 -0 PGMBSAmnGEXXV
;e+<73 A2)BSAst f"
41o4uX
3. !"#$%&'()
.+vuw+xfy67 8! D".F $M4-hi Vc xf@-yD(Transwell)+KzAB
caco-2G--FITC_jEF
4 +{+ SG~
4_{HI WSNSGNFVGGK#~
G67DX4yD#() J|L}K +8!~$~Dx m(R 4~# !" m2)~G+KL
$Qn,*W b-P{tHIDKIHPF67D#!
" |GMNP{t+c<DKIYPSFS+
~# !" D+D ON+k¡+uM-2]
!" (w f+$(NJ¢)£ 4 ST$+(.F $N8!U¤ I67
* + , -
+{+$WP- Th1/Th2stGPt%_F
74QRG-ST.FSMpT+$
Qn4 8v¥+vSB-4 U+V¦8vM4-S OW §
¨©X+uª-$W+«-4 A
¬9(3`#4-:) §¨8!+z+Y
=#]D(42]!" ]^ !©
Z$wZ8()S42 ]-4
G© ®¨¨¯°¨3O~§¨§ .6/ : 4- |¨¨±O§¨©§:4-
S+67) G©n1T+]-4yI
gL8!²³*³[\ ) ®¨
¨¯¡¢])T£O¤2)¥^¦+« ´§
67 ®¨¨±¯¡¨µ©u£O .H ®_¶
¨¯¡/ ©-+ª¯w) «84³
* ³[\ )D DD-oL^¬4 G© `®L+£O9·©-4yL D2)!"$W67) a¸)¨¨±¯¡¯°
±£O ²¯¡¹³ º£O ²¯¡¢] ´£O Sµ¶·b¸¨²¯¡c¹T£O ºde±cfW
» _¨»g ¼ Z ¼½=½
. 34
!"# $%&%
'()*+, - ./01Federico II2 R. Troncone 3456789: ;<=>?@ABC D8E DF GHIJKLDMNOPQRSTU VW3 RFXYDAFZ[\]^2_# ` ab c d,e#fg\]hij 34567 89: ;klm>?@ABCD8E ()nopnF6;
q=n&%rsntu;vwnxy3z{|RFXYDAFE DF h()n}~;FJ \]
Qm ;()nntu;4 q=nS
WDA3JDAFE <=RFAD8E ;QJD AF hW;So=XRDAFhr
2 a Qm ;S¡3JDAF:
;¢=>?@ABCD8E