!"
30
!"# $%&'()*+
,-./0*+,-1/2304 $%&'() 5 6785/29:;<=>?@AB C D-!EFG5HB"8CDI#-
@5JK*D!"> 1995 L(MNAMP (cAMP)-O0P$ $%&'()QR>%STU J # $%&'()>$%&'()*%VW
&(catabolite control protein; CcpA)X'@(*Q R!)*!3G5-*YE/04 1997 OZ[/
0# \]^_`ab)HB G +cd,->e .T f=)\]^<gV=h/i04 # DNAj(`k(C0l1-m/0 23*nN )o<+,-1/0pq CcpAX'@$%&'()
*-dr5@*nN)o<-*YE@si 04 t+,u4-hD-!vw@4
1. #$%&'() *+,-.
198056 $ ')<=x`V$%&'(
)-78 $%&'()QR cAMP5y9:
%VW&!"CRPHz;{<|=*D5p>
T04/E/# 9'^?@ A} cAMP- O0JG5O"B G=*D>A}DB2
~YEKECT2J04
# G')<=x`VHK $%&'() {Q+,78!3 {:!C*T0
Dx`V> D!"i0! 9:;VD-78 5/2E{:!+,-1/04 9:;V
Dz;{ x`V-R#/2B yFGD JacobῌMonodx`V)>%!3G5- $
$H 6D! 5~2IJKL/04 G9:;
Vx`VM6z;{>yM_NL<z;{!"
B G(GntR)%VW&QN+,1HB
DNApI*%VW&> GntRM<
5 yO>J}Tsi2J4 2. / !"01
1970P # $%&'() C D!":)<=ῌ=MV(FBP)>X'/
2JG5-*YE/04 y Q# 9:;V
x`V-78$%&'(){QC*+,- 1/041995R1@# yY}9'^?@
+S $%&'()*Q-*YE/01)4 @
TU9:;<=>?@5 VHWB
C DBFBPXY-ZTF4 FBP HPr%V W&MV d-[JMV@ATP¡@_
`¢(V£¤<¥\¦§!"B FBPXYZHB ]HP-Ser-HPr%VW&XYOZ@4 y/2 23
*¨{!"CcpA%VW&>P-Ser-HPr%VW&5
^IV-©#/$%&'()S_,-(CRE)pI/23
*-ª3«G@4¬5JKO!"i04yY>`a /0G$%&'()Q>.)T $ $%&
'()-)*@=*DHB G(*DK
> b.-®¯$%&'()QRHBcdJ%
/K5°UY2J4
3. -.
1997 >Z[/0e±²f_`ab)H B # \]^+cd,->e.T04 yg # +, f=)\]^<gV=h/i04 # DNA³N_-h/ y-J0DNAj(`k (C0l1-´K/ # )'V=M_)<^C0-µ N5/04 $%&'()+,O\]^:!1>µ N5B P CcpA5P-Ser-HP^IV>i¶/2pI
21 # 9'^?@jGC $%&'()
*QR1) 22 $%&'()*-·/0(catabolism)5k
(anabolism)pl3)
3
9m¸¹nº eop»¼½4m 11
CRE
140 !"#$%&'()*
+ #,$-./0CRE12345
CRE645237
89:3 ;93 DNA<#=0>#
[email protected] A !"#$&
'( BC !"#$
122)6 DEFC$"=G?$- 12HI&8JK
DNA<#=0># %3LM (NO08P3 Q!("#R$3 45 %23& %STU'8(DPVW
$X-=)&4Y3K3) DZ [*+D Z\VN-]^,-6FBP.3/_;P *+`
0-a01% b=2cCcpAd3%
`--4ef*+]^E5!86
CcpA8P-Ser-HPr6g7348%345 9h
3i5:;;j "'klm>$# <m = mf3>n ;93klm:9!op>qmg'
3ilv-leu./001rs86 b=
2g't4uBC?@mAB!Cs!op?@mg ':; vw6DEF:;3xE y >
qmfG+zE{H3]^;PwP| DI GTP8!op>qmJK}L`0-a01
%M(cCodY345ilv-leu./0M~E
9P +G+z]^EN5!86 ` q.O
}L `0-aG+]^%M(cTnrA 34KwP3%;PwEF8Y%V W$X-=c x+5CcpA8P-Ser-HPr6g734 !"#$%3SQDQ78wa"8P
%VW$X-=ERw8Y8E3K
STUV3D129:3K !"#$
%W 3X CcpAf`0-a%M(EL YST%VW$X-=E `"Z[OGCC
Rw6.0`459:c5 ;93\
VW$X-=E"#]^d3w89
%VW$X-=12S_L))]8(DP + `"Z[OGCC36 BC=mC6sQ
` CE+P P9C wa4Q` #2
";j36 *+z8w*b#c3a4Q
` #23>n;j:Edc YST%VW
$X-=!(d6 ` #2"as VW$X-=`>e)& ;93 fC Q6`"Z[OGCCc5 P9g+"d
3JP9`0-a%M(CcpACodYEL w8hi;Pswt5 YST%VW$X-=
6fCj3J8k;P ῌ ῏ ῎ ῍
Y126 lARmRnop qFr"12s (NIH: National Institutes of Health)3t Ernst Freesen
J8BC9+Rt4u"uR$12vw 8 4Vx5yq z{ARBC!
('R$123|} ~ ¡n ¢
n£~ ¤AR¥¦98`m./0!(
12 1987V¤AR3t¢ n98BC !"#$!(12;
s88J3§¨¡n£~ ©ARmRB¦98B CªS« d3t4u01%V W$X-=12;s ;93¬n n9
®pwY12¯';j3K P9°
12388J3 Y128J3n12± £C.
Kang¤²³´n¦12®TARµ"R BR"3¶+
ῒ ῐ
1) Y. Fujita, Y. Miwa, A. Galinier, and J. Deutscher: Mol.
Microbiol.,17, 953ῌ960 (1995).
2) K. Yoshida, K. Kobayashi, Y. Miwa, C.-M. Kang, M.
Matsunaga, H. Yamaguchi, S. Tojo, M. Yamamoto, R. Nishi, N. Ogasawara, T. Nakayama, and Y. Fujita:Nucleic Acids Res.,29, 683ῌ692 (2001).
3) S. Tojo, T. Satomura, K. Morisaki, J. Deutscher, K. Hirooka, and Y. Fujita:Mol. Microbiol.,56, 1560ῌ1573 (2005).