• 検索結果がありません。

Decrease of bone mineral density in Japanese patients with non-metastatic prostate cancer treated with androgen deprivation therapy

N/A
N/A
Protected

Academic year: 2021

シェア "Decrease of bone mineral density in Japanese patients with non-metastatic prostate cancer treated with androgen deprivation therapy"

Copied!
2
0
0

読み込み中.... (全文を見る)

全文

(1)

Title

Decrease of bone mineral density in Japanese patients with non-

metastatic prostate cancer treated with androgen deprivation

therapy( 要約版(Digest) )

Author(s)

加藤, 成一

Report No.(Doctoral

Degree)

博士(医学) 乙第1494号

Issue Date

2018-03-20

Type

博士論文

Version

none

URL

http://hdl.handle.net/20.500.12099/75267

※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。

(2)

࣏ࣜࢪࢺࣜ㛵ಀ㸦ู⣬㸲㸧Repository㸦Form4㸧





Ꮫ఩ㄽᩥせ⣙

Extended Summary in Lieu of the Full Text of a Doctoral Thesis

Ặ ྡ㸸

Full Name

ຍ ⸨ ᡂ ୍

Ꮫ఩ㄽᩥ㢟┠㸸

Thesis Title

Decrease of bone mineral density in Japanese patients with

non-metastatic prostate cancer treated with androgen deprivation

therapy

Ꮫ఩ㄽᩥせ⣙㸸

Summary of Thesis ᪥ᮏ࡟࠾࠸࡚㠀㌿⛣ᛶ๓❧⭢⒴࡟ᑐࡍࡿ $'7 ࡀᝈ⪅ࡢ㦵ᐦᗘ࡟୚࠼ࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵ࡟ᶓ ᩿ㄪᰝࢆ⾜ࡗࡓࠋ  ࠙ᑐ㇟࡜᪉ἲࠚ 㠀㌿⛣ᛶ๓❧⭢⒴ࢆ᭷ࡍࡿ᪥ᮏேࡢ⏨ᛶ࡛ࠊ$'7 ࢆᣢ⥆ⓗ࡟ཷࡅ࡚࠸ࡿ  ே㸦㸣㸧ࠊ࠾ࡼࡧࡇࢀ࠿ࡽ $'7 ཷࡅࡿணᐃࡢ  ே㸦㸣㸧ࠊ࠶ࢃࡏ࡚  ேࢆᑐ㇟࡜ࡋࡓࠋᖹᆒᖺ㱋ࡣ s ṓࠋ$'7 ᪋⾜ᝈ⪅ࡢ ᖹᆒ἞⒪ᮇ㛫ࡣ s ࣧ᭶࡛࠶ࡾࠊ㸰ᖺᮍ‶ࡀ  ே㸦㸧ࠊ㸲ᖺᮍ‶ࡀ  ே㸦㸧ࠊ㸴ᖺᮍ‶ࡀ  ே㸦㸧ࠊ㸴ᖺ௨ୖࡀ  ே㸦㸧࡛࠶ࡗࡓࠋ'(;$ ἲࢆ⏝࠸࡚ᑐ㇟ᝈ⪅ࡢ⭜᳝࡜኱⭣㦵㢁㒊ࡢ㦵ᐦᗘࢆ  ᐃࡋࡓࠋࡲࡓࠊ㢕⬚⭜᳝ࡢ ; ⥺ṇ㠃࠾ࡼࡧഃ㠃ീࢆ᧜ᙳࡋࠊ᳝య㦵ᢡࡢ᭷↓ࢆㄪᰝࡋࡓࠋࡲࡓࠊ㦵௦ㅰ࣐ ࣮࣮࢝࡜ࡋ࡚ %$3 ࡜ XULQH17[ ࡲࡓࡣ 75$&3E ࢆ ᐃࡋࠊ㦵௦ㅰࡢ≧ែࢆㄪ࡭ࡓࠋࡉࡽ࡟ࠊデ⒪㘓ࡸ㉁ၥ⣬ ࢆ⏝࠸࡚ᖺ㱋ࠊ%0,ࠊ$'7 ࡢෆᐜࠊ$'7 㛤ጞ᫬ࡢ 36$ࠊ⬨᳝ࡲࡓࡣ኱⭣㦵㦵ᢡࡢ᪤ Ṕ࠾ࡼࡧᐙ᪘Ṕࠊ$'7 ୰ ࡢ㦵ᢡࠊႚ↮ࠊ㐣ᗘࡢ㣧㓇ࠊ㧗⾑ᅽࠊ⢾ᒀ⑓ࠊ៏ᛶ⭈⮚⑓ࠊ㛵⠇࣐ࣜ࢘ࢳࠊࢫࢸࣟ࢖ࢻ౑⏝ࡢ᭷↓ࢆㄪᰝࡋࠊ 㦵ᐦᗘ࡟ᙳ㡪ࢆ୚࠼࠺ࡿせᅉࢆㄪᰝࡋࡓࠋ  ࠙⤖ᯝࠚ  $'7 ࡢ἞⒪ᮇ㛫ࡀ㛗ࡃ࡞ࡿ࡟ᚑ࠸ࠊ'(;$ ἲ࡟࠾ࡅࡿ⭜᳝࠾ࡼࡧ኱⭣㦵㢁㒊ࡢ㦵ᐦᗘࡣ᭷ព࡟పୗࡋࡓ㸦ࡑ ࢀࡒࢀ S  ࡜ S  ࠋ༢ኚ㔞ゎᯒ࡟࠾࠸࡚⭜᳝ࡢ㦵ᐦᗘ࡟ᙳ㡪ࢆ୚࠼ࡿ᭷ព࡞ᅉᏊࡣࠊ $'7 ࡢ἞⒪ᮇ㛫ࠊ%0,ࠊ; ⥺⏬ീୖࡢ⬨᳝㦵ᢡࠊ%$3ࠊXULQH17[ ࠾ࡼࡧ 75$&3E ࡛࠶ࡾࠊ኱⭣㦵㢕㒊ࡢ 㦵ᐦᗘ࡟ᙳ㡪ࢆ୚࠼ࡿ᭷ព࡞ᅉᏊࡣࠊ$'7 ࡢ἞⒪ᮇ㛫ࠊ%0,ࠊᖺ㱋ࠊ; ⥺⏬ീୖࡢ⬨᳝㦵ᢡࠊ%$3ࠊXULQH 17[ ࠾ࡼࡧ 75$&3E ࡛࠶ࡗࡓࠋḟ࡟㏲ḟ㔜ᅇᖐศᯒࢆ⾜࠸ࠊ$'7 ࡢ἞⒪ᮇ㛫ࡣ⭜᳝࠾ࡼࡧ኱⭣㦵㢁㒊ࡢ 㦵ᐦᗘ࡟ᙳ㡪ࢆཬࡰࡍ᭷ព࡞ᅉᏊࡢࡦ࡜ࡘ࡛࠶ࡿࡇ࡜ࢆ☜ㄆࡋࡓ㸦S 㸧ࠋ ⭜᳝࠾ࡼࡧ኱⭣㦵㢕㒊ࡢ㦵ᐦᗘࢆࡶ࡜࡟ :+2 ࡢ㦵⢒㧼⑕デ᩿ᇶ‽࡟ᚑࡗ࡚ศ㢮ࡍࡿ࡜ࠊṇᖖࠊ㦵ῶᑡࠊ 㦵⢒㧼⑕ࡀࡑࢀࡒࢀ  ே㸦㸧ࠊ ே㸦㸧ࠊ ே㸦㸧࡛࠶ࡗࡓࠋ$'7 ࡢ἞⒪ᮇ㛫ࡀ㛗ࡃ ࡞ࡿ࡟ᚑ࠸ࠊ㦵⢒㧼⑕ࡢ᭷⑓⋡ࡣ᭷ព࡟ቑຍࡋ㸦S 㸧ࠊ$'7 㛤ጞ๓ࡢ ࡛࠶ࡗࡓ㦵⢒㧼⑕ࡢ ᭷⑓⋡ࡣࠊ ᖺ௨ୖࡢ $'7 ࡢ⥅⥆࡛ ࡟ୖ᪼ࡋࡓࠋ༢ኚ㔞ゎᯒ࡟࠾࠸࡚ࠊ㦵⢒㧼⑕ࡢデ᩿࡟ᙳ㡪ࢆ ୚࠼ࡿ᭷ព࡞ᅉᏊࡣࠊ$'7 ࡢ἞⒪ᮇ㛫ࠊ%0,ࠊᖺ㱋ࠊ; ⥺⏬ീୖࡢ᳝య㦵ᢡ࠾ࡼࡧ %$3 ࡛࠶ࡗࡓࠋࡑࡇ࡛ ከኚ㔞ࣟࢪࢫࢸࢵࢡᅇᖐศᯒࢆ⾜࠸ࠊ$'7 ࡢ἞⒪ᮇ㛫ࡣ㦵⢒㧼⑕デ᩿࡟ᙳ㡪ࢆཬࡰࡍ᭷ព࡞ᅉᏊࡢࡦ࡜ ࡘ࡛࠶ࡿࡇ࡜ࢆ☜ㄆࡋࡓ㸦S 㸧ࠋ  ࠙⤖ㄽࠚ ᪥ᮏேࡢ㠀㌿⛣ᛶ๓❧⭢⒴ᝈ⪅࡟࠾࠸࡚ࠊ$'7 ࡣ⭜᳝࠾ࡼࡧ኱⭣㦵㢁㒊ࡢ㦵ᐦᗘ࡟㈇ࡢᙳ㡪ࢆ୚࠼ࠊ ࡲࡓࠊ἞⒪ᮇ㛫ࡢᘏ㛗࡟ᚑ࠸ࠊ㦵⢒㧼⑕ࡢ᭷⑓⋡ࡶቑຍࡍࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋ᪥ᮏ࡟࠾࠸࡚㠀㌿⛣ᛶ๓ ❧⭢⒴࡟ᑐࡍࡿ࢔ࣥࢻࣟࢤࣥ㝖ཤ⒪ἲࡀᝈ⪅ࡢ㦵ᐦᗘ࡟୚࠼ࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵ࡟ᶓ᩿ㄪᰝࢆ ⾜ࡗࡓࠋ 



参照

関連したドキュメント

In this study, to evaluate the potential of radioiodinated ( + )-pIV for tumor imaging and receptor radionuclide therapy, we selected human DU-145 prostate cancer cells known to

Figure 1 illustrates the changes in the HHV-6 copy number in 7 patients who required.

A possible mechanism involved in the enhanced production of HCMV by dexamethasone is hormone enhancement of virus adsorption or stimulation of cell growth.. It is known that HCMV

To investigate whether defects in the SPATA17 gene are associated with azoospermia due to meiotic arrest, a mutational analysis was conducted, in which the SPATA17 coding regions

Intensification Therapy with Anti-Parathyroid Hormone-related Protein Antibody Plus Zoledronic Acid for Bone Metastases of Small Cell Lung Cancer Cells in SCID Mice.. Tadaaki

The impact of rotational error regarding the treatment of prostate cancer with VMAT has not yet been evaluated, and our preliminary study showed that pitch angle error affected

Met expression in A2058 melanoma cells was relatively heterogeneous, and a re- analysis of Met-low and Met-high cells after cell sorting indicated that Met-low and Met-high

Methods: IgG and IgM anti-cardiolipin antibodies (aCL), IgG anti-cardiolipin-β 2 glycoprotein I complex antibody (aCL/β 2 GPI), and IgG anti-phosphatidylserine-prothrombin complex